locus-tag	class	description
FEZ30_00065	COG1022	Amp-dependent synthetase and ligase
FEZ30_00075	COG0672	)-iron permease
FEZ30_00085	COG2837	iron assimilation
FEZ30_00090	COG0360	Binds together with S18 to 16S ribosomal RNA
FEZ30_00100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FEZ30_00105	COG0359	binds to the 23S rRNA
FEZ30_00115	COG1968	undecaprenyl-diphosphatase activity
FEZ30_00150	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FEZ30_00160	COG2205	protein histidine kinase activity
FEZ30_00175	COG1609	Transcriptional regulator
FEZ30_00185	COG1175	transmembrane transport
FEZ30_00190	COG0395	ABC-type sugar transport system, permease component
FEZ30_00210	COG2423	ornithine cyclodeaminase activity
FEZ30_00225	COG1132	(ABC) transporter
FEZ30_00245	COG0366	Alpha amylase catalytic
FEZ30_00250	COG0395	ABC-type sugar transport system, permease component
FEZ30_00265	COG1940	carbohydrate kinase activity
FEZ30_00285	COG1285	pathogenesis
FEZ30_00290	COG1175	transmembrane transport
FEZ30_00295	COG0395	ABC-type sugar transport system, permease component
FEZ30_00300	COG1653	transport
FEZ30_00335	COG0366	Alpha amylase catalytic
FEZ30_00405	COG0477	Major facilitator Superfamily
FEZ30_00410	COG1621	beta-fructofuranosidase activity
FEZ30_00425	COG5002	protein histidine kinase activity
FEZ30_00435	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FEZ30_00435	COG3976	FMN-binding domain protein
FEZ30_00465	COG1715	Restriction endonuclease
FEZ30_00495	COG4691	Plasmid stability protein
FEZ30_00510	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
FEZ30_00515	COG3311	Transcriptional regulator
FEZ30_00560	COG0765	amino acid transport
FEZ30_00565	COG0765	amino acid transport
FEZ30_00570	COG1126	abc transporter atp-binding protein
FEZ30_00590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FEZ30_00595	COG0154	amidase activity
FEZ30_00635	COG0006	proline dipeptidase activity
FEZ30_00640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEZ30_00650	COG0477	Major facilitator Superfamily
FEZ30_00675	COG1233	COG1233 Phytoene dehydrogenase and related
FEZ30_00685	COG0022	dehydrogenase e1 component
FEZ30_00690	COG0508	dehydrogenase complex catalyzes the overall conversion of
FEZ30_00700	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FEZ30_00710	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FEZ30_00730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FEZ30_00750	COG3833	ABC-type maltose transport systems, permease component
FEZ30_00765	COG1609	Transcriptional regulator
FEZ30_00770	COG0561	phosphatase activity
FEZ30_00790	COG0137	argininosuccinate synthase activity
FEZ30_00795	COG1028	Short-chain dehydrogenase reductase Sdr
FEZ30_00795	COG0604	alcohol dehydrogenase
FEZ30_00795	COG3321	synthase
FEZ30_00820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FEZ30_00825	COG1609	Transcriptional regulator
FEZ30_00830	COG1316	TRANSCRIPTIONal
FEZ30_00855	COG0584	glycerophosphoryl diester phosphodiesterase
FEZ30_00860	COG4946	Tricorn protease homolog
FEZ30_00860	COG0823	Involved in the tonB-independent uptake of proteins
FEZ30_00860	COG1506	peptidase
FEZ30_00865	COG2130	NADP-dependent
FEZ30_00890	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FEZ30_00925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FEZ30_00935	COG1174	glycine betaine transport
FEZ30_00945	COG1125	glycine betaine transport
FEZ30_00945	COG0517	IMP dehydrogenase activity
FEZ30_00950	COG3263	regulation of cellular component size
FEZ30_00965	COG0433	COG0433 Predicted ATPase
FEZ30_00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FEZ30_00995	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FEZ30_01010	COG1942	4-Oxalocrotonate Tautomerase
FEZ30_01015	COG0673	inositol 2-dehydrogenase activity
FEZ30_01025	COG1946	Acyl-CoA thioesterase
FEZ30_01030	COG2376	Dihydroxyacetone kinase
FEZ30_01035	COG1063	alcohol dehydrogenase
FEZ30_01040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FEZ30_01050	COG1064	alcohol dehydrogenase
FEZ30_01060	COG0390	transport system, permease component
FEZ30_01065	COG0671	phosphoesterase, PA-phosphatase related
FEZ30_01070	COG1968	undecaprenyl-diphosphatase activity
FEZ30_01075	COG0745	RESPONSE REGULATOR receiver
FEZ30_01085	COG0438	transferase activity, transferring glycosyl groups
FEZ30_01095	COG0586	Pfam SNARE associated Golgi protein
FEZ30_01110	COG0183	Belongs to the thiolase family
FEZ30_01120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FEZ30_01130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FEZ30_01145	COG0402	S-adenosylhomocysteine deaminase activity
FEZ30_01185	COG3158	transport of potassium into the cell
FEZ30_01205	COG4572	Cation transport regulator
FEZ30_01225	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FEZ30_01250	COG1295	ribonuclease BN
FEZ30_01260	COG1028	Short-chain dehydrogenase reductase Sdr
FEZ30_01265	COG0783	Belongs to the Dps family
FEZ30_01275	COG1028	Short-chain dehydrogenase reductase Sdr
FEZ30_01280	COG2124	cytochrome p450
FEZ30_01285	COG1793	dna ligase
FEZ30_01285	COG3285	dna ligase
FEZ30_01305	COG2197	response regulator
FEZ30_01315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FEZ30_01315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FEZ30_01350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FEZ30_01355	COG0534	Mate efflux family protein
FEZ30_01365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FEZ30_01380	COG1072	(Pantothenic acid kinase))
FEZ30_01385	COG1069	ribulokinase activity
FEZ30_01400	COG3022	response to hydroperoxide
FEZ30_01415	COG4608	Belongs to the ABC transporter superfamily
FEZ30_01420	COG0444	Belongs to the ABC transporter superfamily
FEZ30_01425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FEZ30_01430	COG0601	transmembrane transport
FEZ30_01460	COG1846	Transcriptional regulator
FEZ30_01465	COG2040	homocysteine
FEZ30_01470	COG0833	amino acid
FEZ30_01490	COG1408	metallophosphoesterase
FEZ30_01495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FEZ30_01530	COG0494	nUDIX hydrolase
FEZ30_01620	COG1111	helicase
FEZ30_01620	COG1205	dead DEAH box helicase
FEZ30_01625	COG2890	protein-(glutamine-N5) methyltransferase activity
FEZ30_01635	COG1754	DNA topoisomerase type I activity
FEZ30_01635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FEZ30_01645	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FEZ30_01650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FEZ30_01660	COG1774	PSP1 C-terminal conserved region
FEZ30_01700	COG1231	oxidoreductase activity
FEZ30_01705	COG0431	NADPH-dependent FMN reductase
FEZ30_01730	COG0601	transmembrane transport
FEZ30_01735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FEZ30_01740	COG4172	Belongs to the ABC transporter superfamily
FEZ30_01745	COG1619	proteins homologs of microcin C7 resistance protein MccF
FEZ30_01750	COG1522	sequence-specific DNA binding
FEZ30_01795	COG2062	phosphohistidine phosphatase, SixA
FEZ30_01800	COG3458	cephalosporin-C deacetylase activity
FEZ30_01810	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FEZ30_01820	COG0037	tRNA processing
FEZ30_01835	COG0302	gtp cyclohydrolase
FEZ30_01840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FEZ30_01845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FEZ30_01850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FEZ30_01865	COG0649	NAD binding
FEZ30_01875	COG0542	response to heat
FEZ30_01880	COG0270	DNA (cytosine-5-)-methyltransferase activity
FEZ30_01960	COG0457	Tetratricopeptide repeat
FEZ30_01960	COG0705	Rhomboid family
FEZ30_01970	COG4143	(ABC) transporter
FEZ30_01980	COG3842	ATPase activity
FEZ30_01990	COG1194	a g-specific adenine glycosylase
FEZ30_01995	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FEZ30_02000	COG0113	porphobilinogen synthase activity
FEZ30_02010	COG0181	hydroxymethylbilane synthase activity
FEZ30_02020	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FEZ30_02025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FEZ30_02040	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FEZ30_02045	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FEZ30_02050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FEZ30_02060	COG1082	Xylose isomerase domain protein TIM barrel
FEZ30_02065	COG0506	proline dehydrogenase activity
FEZ30_02080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FEZ30_02095	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FEZ30_02100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FEZ30_02100	COG1648	precorrin-2 dehydrogenase activity
FEZ30_02105	COG0406	alpha-ribazole phosphatase activity
FEZ30_02110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FEZ30_02115	COG0785	Cytochrome C biogenesis protein
FEZ30_02125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FEZ30_02145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FEZ30_02150	COG2409	Drug exporters of the RND superfamily
FEZ30_02160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FEZ30_02165	COG0129	dihydroxy-acid dehydratase activity
FEZ30_02185	COG1120	ATPase activity
FEZ30_02190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FEZ30_02195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FEZ30_02200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FEZ30_02205	COG0803	Belongs to the bacterial solute-binding protein 9 family
FEZ30_02215	COG1121	(ABC) transporter
FEZ30_02220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FEZ30_02235	COG0523	cobalamin synthesis protein
FEZ30_02240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FEZ30_02245	COG0254	rRNA binding
FEZ30_02250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FEZ30_02260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FEZ30_02265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FEZ30_02290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FEZ30_02295	COG0745	RESPONSE REGULATOR receiver
FEZ30_02320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FEZ30_02395	COG3485	protocatechuate 3,4-dioxygenase
FEZ30_02405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FEZ30_02420	COG2337	Toxic component of a toxin-antitoxin (TA) module
FEZ30_02435	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEZ30_02440	COG1937	Protein conserved in bacteria
FEZ30_02455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FEZ30_02460	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
FEZ30_02465	COG4423	Transcription factor
FEZ30_02470	COG0151	Belongs to the GarS family
FEZ30_02475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FEZ30_02485	COG3634	alkyl hydroperoxide reductase activity
FEZ30_02490	COG0450	alkyl hydroperoxide reductase
FEZ30_02495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FEZ30_02500	COG0047	phosphoribosylformylglycinamidine synthase activity
FEZ30_02505	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FEZ30_02515	COG1113	amino acid transport
FEZ30_02520	COG0252	asparaginase activity
FEZ30_02535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FEZ30_02575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FEZ30_02600	COG0395	ABC-type sugar transport system, permease component
FEZ30_02785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FEZ30_02800	COG0574	Belongs to the PEP-utilizing enzyme family
FEZ30_02800	COG3848	Pyruvate phosphate dikinase
FEZ30_02845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FEZ30_02855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FEZ30_02875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FEZ30_02880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FEZ30_02895	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FEZ30_02895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEZ30_02895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FEZ30_02900	COG1461	Dihydroxyacetone kinase
FEZ30_02905	COG2376	Dihydroxyacetone kinase
FEZ30_02925	COG1132	(ABC) transporter
FEZ30_02935	COG2226	methyltransferase
FEZ30_02940	COG1131	(ABC) transporter
FEZ30_02970	COG0644	oxidoreductase
FEZ30_02980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FEZ30_02985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FEZ30_02990	COG0649	NAD binding
FEZ30_03000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FEZ30_03005	COG1034	ATP synthesis coupled electron transport
FEZ30_03010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FEZ30_03015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FEZ30_03025	COG0713	ATP synthesis coupled electron transport
FEZ30_03040	COG1007	ATP synthesis coupled electron transport
FEZ30_03090	COG3590	peptidase
FEZ30_03095	COG1013	pyruvate-flavodoxin oxidoreductase activity
FEZ30_03100	COG0674	pyruvate-flavodoxin oxidoreductase activity
FEZ30_03100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FEZ30_03105	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FEZ30_03110	COG0649	NAD binding
FEZ30_03110	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FEZ30_03115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FEZ30_03155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FEZ30_03160	COG2030	dehydratase
FEZ30_03170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FEZ30_03175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEZ30_03190	COG0250	Participates in transcription elongation, termination and antitermination
FEZ30_03195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FEZ30_03200	COG0081	regulation of translation
FEZ30_03205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FEZ30_03210	COG0222	ribosome binding
FEZ30_03215	COG0085	RNA polymerase activity
FEZ30_03220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FEZ30_03235	COG0673	inositol 2-dehydrogenase activity
FEZ30_03240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FEZ30_03245	COG0049	tRNA binding
FEZ30_03250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FEZ30_03255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FEZ30_03270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FEZ30_03275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FEZ30_03280	COG0051	transcription antitermination factor activity, RNA binding
FEZ30_03285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FEZ30_03290	COG0088	Forms part of the polypeptide exit tunnel
FEZ30_03295	COG0089	rRNA binding
FEZ30_03300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FEZ30_03305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FEZ30_03310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FEZ30_03315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FEZ30_03320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FEZ30_03325	COG0255	Belongs to the universal ribosomal protein uL29 family
FEZ30_03330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FEZ30_03350	COG1175	transmembrane transport
FEZ30_03355	COG0395	ABC-type sugar transport system, permease component
FEZ30_03360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FEZ30_03365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FEZ30_03370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FEZ30_03375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FEZ30_03380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FEZ30_03385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FEZ30_03390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FEZ30_03395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FEZ30_03400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FEZ30_03405	COG1841	ribosomal large subunit assembly
FEZ30_03410	COG0200	Binds to the 23S rRNA
FEZ30_03445	COG0563	adenylate kinase activity
FEZ30_03465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FEZ30_03470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FEZ30_03480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FEZ30_03485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FEZ30_03490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FEZ30_03495	COG0202	RNA polymerase activity
FEZ30_03500	COG0203	ribosomal protein L17
FEZ30_03505	COG0438	transferase activity, transferring glycosyl groups
FEZ30_03515	COG0519	Catalyzes the synthesis of GMP from XMP
FEZ30_03515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FEZ30_03530	COG3845	ABC transporter
FEZ30_03535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FEZ30_03550	COG0101	tRNA pseudouridine synthase activity
FEZ30_03555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FEZ30_03575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FEZ30_03580	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FEZ30_03585	COG1028	Short-chain dehydrogenase reductase Sdr
FEZ30_03590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FEZ30_03600	COG1072	(Pantothenic acid kinase))
FEZ30_03605	COG2226	methyltransferase
FEZ30_03610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FEZ30_03615	COG0736	holo-[acyl-carrier-protein] synthase activity
FEZ30_03630	COG0513	Belongs to the DEAD box helicase family
FEZ30_03635	COG0802	atpase or kinase
FEZ30_03640	COG0456	acetyltransferase
FEZ30_03640	COG1214	PFAM Peptidase M22, glycoprotease
FEZ30_03650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FEZ30_03670	COG1355	regulation of microtubule-based process
FEZ30_03690	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FEZ30_03695	COG0459	protein refolding
FEZ30_03715	COG1605	Chorismate mutase
FEZ30_03715	COG0287	Prephenate dehydrogenase
FEZ30_03720	COG1045	serine acetyltransferase
FEZ30_03725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FEZ30_03725	COG0519	Catalyzes the synthesis of GMP from XMP
FEZ30_03750	COG2197	response regulator
FEZ30_03755	COG2261	transglycosylase associated protein
FEZ30_03765	COG2011	ABC-type metal ion transport system permease component
FEZ30_03770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FEZ30_03775	COG1464	Belongs to the NlpA lipoprotein family
FEZ30_03790	COG0045	succinate-CoA ligase (ADP-forming) activity
FEZ30_03820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FEZ30_03820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FEZ30_03825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FEZ30_03835	COG0138	bifunctional purine biosynthesis protein purh
FEZ30_03845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FEZ30_03860	COG0039	L-malate dehydrogenase activity
FEZ30_03880	COG1253	flavin adenine dinucleotide binding
FEZ30_03925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FEZ30_03945	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
FEZ30_03955	COG5275	peptidyl-tyrosine sulfation
FEZ30_03955	COG0252	asparaginase activity
FEZ30_03960	COG4656	Part of a membrane complex involved in electron transport
FEZ30_03965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FEZ30_03980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FEZ30_04000	COG4770	biotin carboxylase activity
FEZ30_04010	COG0351	phosphomethylpyrimidine kinase
FEZ30_04020	COG4221	oxidoreductase activity
FEZ30_04035	COG0424	maF-like protein
FEZ30_04045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FEZ30_04055	COG3340	Belongs to the peptidase S51 family
FEZ30_04075	COG1316	TRANSCRIPTIONal
FEZ30_04095	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FEZ30_04095	COG0662	Cupin 2, conserved barrel domain protein
FEZ30_04145	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FEZ30_04175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FEZ30_04190	COG1918	ferrous iron import across plasma membrane
FEZ30_04190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FEZ30_04200	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FEZ30_04205	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FEZ30_04210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FEZ30_04215	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FEZ30_04225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FEZ30_04250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FEZ30_04275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FEZ30_04290	COG0587	DNA-directed DNA polymerase activity
FEZ30_04300	COG0531	amino acid
FEZ30_04305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FEZ30_04340	COG1131	(ABC) transporter
FEZ30_04355	COG1113	amino acid transport
FEZ30_04365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FEZ30_04380	COG2197	response regulator
FEZ30_04385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FEZ30_04395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FEZ30_04420	COG1794	racemase activity, acting on amino acids and derivatives
FEZ30_04425	COG0519	Catalyzes the synthesis of GMP from XMP
FEZ30_04435	COG4106	trans-aconitate 2-methyltransferase activity
FEZ30_04445	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FEZ30_04470	COG0277	FAD linked oxidase domain protein
FEZ30_04470	COG0247	lactate metabolic process
FEZ30_04485	COG1022	Amp-dependent synthetase and ligase
FEZ30_04500	COG2814	Major facilitator Superfamily
FEZ30_04510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FEZ30_04525	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FEZ30_04530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FEZ30_04545	COG0698	ribose 5-phosphate isomerase
FEZ30_04565	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FEZ30_04565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FEZ30_04585	COG0544	peptidyl-prolyl cis-trans isomerase activity
FEZ30_04595	COG0740	serine-type endopeptidase activity
FEZ30_04600	COG0740	serine-type endopeptidase activity
FEZ30_04605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FEZ30_04615	COG0793	Belongs to the peptidase S41A family
FEZ30_04615	COG4946	Tricorn protease homolog
FEZ30_04630	COG0525	valine-tRNA ligase activity
FEZ30_04640	COG0363	glucosamine-6-phosphate deaminase activity
FEZ30_04655	COG0109	protoheme IX farnesyltransferase activity
FEZ30_04660	COG1612	heme a metabolic process
FEZ30_04670	COG1131	(ABC) transporter
FEZ30_04675	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FEZ30_04680	COG1609	Transcriptional regulator
FEZ30_04685	COG3833	ABC-type maltose transport systems, permease component
FEZ30_04690	COG1175	transmembrane transport
FEZ30_04705	COG0719	Fe-S assembly protein
FEZ30_04720	COG0396	ATPase activity
FEZ30_04725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FEZ30_04755	COG0110	maltose O-acetyltransferase activity
FEZ30_04770	COG0488	(ABC) transporter
FEZ30_04800	COG1028	Short-chain dehydrogenase reductase Sdr
FEZ30_04825	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FEZ30_04830	COG1119	ATPase activity
FEZ30_04865	COG0242	peptide deformylase activity
FEZ30_04875	COG4974	Belongs to the 'phage' integrase family
FEZ30_04890	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FEZ30_04900	COG0714	Associated with various cellular activities
FEZ30_04910	COG3831	ATPase activity
FEZ30_04915	COG0052	Belongs to the universal ribosomal protein uS2 family
FEZ30_04920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FEZ30_04925	COG0528	UMP kinase activity
FEZ30_04930	COG0233	cytoplasmic translational termination
FEZ30_04935	COG0575	Belongs to the CDS family
FEZ30_04940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FEZ30_04945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FEZ30_04955	COG0750	zinc metalloprotease
FEZ30_04960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FEZ30_04990	COG1305	Transglutaminase-like
FEZ30_05000	COG0442	prolyl-tRNA aminoacylation
FEZ30_05020	COG0779	Required for maturation of 30S ribosomal subunits
FEZ30_05025	COG0195	Participates in both transcription termination and antitermination
FEZ30_05035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FEZ30_05045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FEZ30_05050	COG0371	Dehydrogenase
FEZ30_05065	COG3732	PTS system glucitol sorbitol-specific
FEZ30_05085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FEZ30_05105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FEZ30_05110	COG2801	Transposase and inactivated derivatives
FEZ30_05115	COG1185	polyribonucleotide nucleotidyltransferase activity
FEZ30_05120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FEZ30_05130	COG0028	Belongs to the TPP enzyme family
FEZ30_05140	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FEZ30_05145	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FEZ30_05165	COG0742	ribosomal rna small subunit methyltransferase
FEZ30_05170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FEZ30_05180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FEZ30_05185	COG0571	ribonuclease III activity
FEZ30_05190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FEZ30_05195	COG0656	L-ascorbic acid biosynthetic process
FEZ30_05250	COG0228	four-way junction DNA binding
FEZ30_05255	COG1837	Belongs to the UPF0109 family
FEZ30_05260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FEZ30_05265	COG0336	Belongs to the RNA methyltransferase TrmD family
FEZ30_05275	COG1053	succinate dehydrogenase
FEZ30_05280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FEZ30_05285	COG0335	large ribosomal subunit rRNA binding
FEZ30_05290	COG0681	Belongs to the peptidase S26 family
FEZ30_05295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FEZ30_05305	COG0792	nuclease activity
FEZ30_05310	COG0606	chelatase, subunit chli
FEZ30_05335	COG1175	transmembrane transport
FEZ30_05340	COG0395	ABC-type sugar transport system, permease component
FEZ30_05345	COG1609	Transcriptional regulator
FEZ30_05355	COG0395	ABC-type sugar transport system, permease component
FEZ30_05385	COG2160	L-arabinose isomerase activity
FEZ30_05390	COG1609	Transcriptional regulator
FEZ30_05400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FEZ30_05410	COG0667	Aldo Keto reductase
FEZ30_05420	COG3201	nicotinamide mononucleotide transporter
FEZ30_05425	COG0140	phosphoribosyl-ATP diphosphatase activity
FEZ30_05430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FEZ30_05470	COG0647	UMP catabolic process
FEZ30_05475	COG1268	BioY protein
FEZ30_05480	COG1122	ATPase activity
FEZ30_05495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FEZ30_05500	COG0497	DNA recombination
FEZ30_05505	COG0504	CTP synthase activity
FEZ30_05540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FEZ30_05560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FEZ30_05580	COG0107	imidazoleglycerol-phosphate synthase activity
FEZ30_05585	COG0537	adenosine 5'-monophosphoramidase activity
FEZ30_05595	COG0440	acetolactate synthase activity
FEZ30_05600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FEZ30_05620	COG0473	3-isopropylmalate dehydrogenase activity
FEZ30_05625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FEZ30_05630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FEZ30_05640	COG0179	Fumarylacetoacetate (FAA) hydrolase
FEZ30_05660	COG1414	Transcriptional regulator
FEZ30_05665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FEZ30_05670	COG0066	3-isopropylmalate dehydratase activity
FEZ30_05680	COG1181	Belongs to the D-alanine--D-alanine ligase family
FEZ30_05700	COG1674	ftsk spoiiie
FEZ30_05710	COG3152	Membrane
FEZ30_05725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FEZ30_05730	COG2884	Cell division ATP-binding protein ftsE
FEZ30_05735	COG2177	Part of the ABC transporter FtsEX involved in
FEZ30_05740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FEZ30_05745	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FEZ30_05755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FEZ30_05760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FEZ30_05765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FEZ30_05770	COG0165	Argininosuccinate lyase
FEZ30_05785	COG1678	Uncharacterized ACR, COG1678
FEZ30_05790	COG0745	RESPONSE REGULATOR receiver
FEZ30_05795	COG5002	protein histidine kinase activity
FEZ30_05800	COG5401	PFAM Sporulation and spore germination
FEZ30_05810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FEZ30_05820	COG0653	protein targeting
FEZ30_05840	COG0613	PHP domain protein
FEZ30_05850	COG0180	Tryptophanyl-tRNA synthetase
FEZ30_05875	COG1278	Cold shock
FEZ30_05880	COG0210	DNA helicase
FEZ30_05895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FEZ30_05905	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FEZ30_05935	COG3480	Lon protease (S16) C-terminal proteolytic domain
FEZ30_05945	COG1615	UPF0182 protein
FEZ30_05975	COG0747	negative chemotaxis
FEZ30_06000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FEZ30_06005	COG0483	inositol monophosphate 1-phosphatase activity
FEZ30_06015	COG1162	GTPase activity
FEZ30_06020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FEZ30_06030	COG1595	DNA-templated transcription, initiation
FEZ30_06055	COG0567	Dehydrogenase, E1 component
FEZ30_06055	COG0508	dehydrogenase complex catalyzes the overall conversion of
FEZ30_06065	COG1611	Belongs to the LOG family
FEZ30_06075	COG0019	diaminopimelate decarboxylase activity
FEZ30_06080	COG0460	homoserine dehydrogenase
FEZ30_06085	COG0083	homoserine kinase activity
FEZ30_06095	COG0254	rRNA binding
FEZ30_06100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FEZ30_06105	COG2890	protein-(glutamine-N5) methyltransferase activity
FEZ30_06115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FEZ30_06185	COG0318	PFAM AMP-dependent synthetase and ligase
FEZ30_06195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FEZ30_06200	COG0367	asparagine synthase
FEZ30_06210	COG1045	serine acetyltransferase
FEZ30_06225	COG0356	it plays a direct role in the translocation of protons across the membrane
FEZ30_06230	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FEZ30_06235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FEZ30_06240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FEZ30_06245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FEZ30_06250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FEZ30_06255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FEZ30_06260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FEZ30_06315	COG0033	Phosphoglucomutase
FEZ30_06325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEZ30_06340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FEZ30_06345	COG3281	Trehalose synthase
FEZ30_06350	COG0366	Alpha amylase catalytic
FEZ30_06370	COG0482	sulfurtransferase activity
FEZ30_06385	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FEZ30_06395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FEZ30_06410	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FEZ30_06415	COG0154	amidase activity
FEZ30_06420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FEZ30_06425	COG2233	PERMEase
FEZ30_06430	COG2233	PERMEase
FEZ30_06445	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FEZ30_06450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FEZ30_06465	COG0134	indole-3-glycerol-phosphate synthase activity
FEZ30_06475	COG0159	tryptophan synthase activity
FEZ30_06480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FEZ30_06485	COG0067	glutamate synthase
FEZ30_06485	COG0069	glutamate synthase activity
FEZ30_06485	COG0070	glutamate synthase
FEZ30_06505	COG0395	ABC-type sugar transport system, permease component
FEZ30_06540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FEZ30_06545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FEZ30_06550	COG0131	Imidazoleglycerol-phosphate dehydratase
FEZ30_06555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FEZ30_06560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FEZ30_06565	COG0217	transcriptional regulatory protein
FEZ30_06570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FEZ30_06575	COG0632	four-way junction helicase activity
FEZ30_06580	COG2255	four-way junction helicase activity
FEZ30_06590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FEZ30_06595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FEZ30_06600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FEZ30_06610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FEZ30_06615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FEZ30_06620	COG1196	nuclear chromosome segregation
FEZ30_06625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FEZ30_06630	COG0124	histidyl-tRNA synthetase
FEZ30_06640	COG1309	transcriptional regulator
FEZ30_06655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FEZ30_06690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FEZ30_06695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FEZ30_06700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FEZ30_06705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FEZ30_06710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FEZ30_06715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FEZ30_06720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FEZ30_06730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FEZ30_06735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FEZ30_06745	COG0194	GDP metabolic process
FEZ30_06750	COG1758	RNA polymerase activity
FEZ30_06760	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FEZ30_06765	COG1201	RNA secondary structure unwinding
FEZ30_06770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FEZ30_06805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FEZ30_06815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FEZ30_06825	COG1410	methionine synthase
FEZ30_06825	COG0646	methionine synthase
FEZ30_06840	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FEZ30_06845	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FEZ30_06855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FEZ30_06860	COG1160	GTP binding
FEZ30_06870	COG1764	response to oxidative stress
FEZ30_06905	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FEZ30_06930	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FEZ30_06940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEZ30_06960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FEZ30_06970	COG0277	FAD linked oxidase domain protein
FEZ30_06985	COG3226	Transcriptional regulator
FEZ30_07025	COG3550	peptidyl-serine autophosphorylation
FEZ30_07060	COG2807	transmembrane transport
FEZ30_07085	COG0427	acetyl-CoA hydrolase
FEZ30_07090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FEZ30_07095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FEZ30_07095	COG2813	Specifically methylates the guanine in position
FEZ30_07100	COG1522	sequence-specific DNA binding
FEZ30_07105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FEZ30_07110	COG1216	Glycosyl transferase, family 2
FEZ30_07125	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FEZ30_07130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FEZ30_07140	COG1966	Carbon starvation protein
FEZ30_07155	COG0531	amino acid
FEZ30_07205	COG1739	Uncharacterized protein family UPF0029
FEZ30_07210	COG1472	Belongs to the glycosyl hydrolase 3 family
FEZ30_07215	COG1597	lipid kinase activity
FEZ30_07220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FEZ30_07225	COG0009	L-threonylcarbamoyladenylate synthase
FEZ30_07235	COG0205	6-phosphofructokinase activity
FEZ30_07240	COG1295	ribonuclease BN
FEZ30_07260	COG1716	ATPase activity
FEZ30_07290	COG0438	transferase activity, transferring glycosyl groups
FEZ30_07295	COG1560	Kdo2-lipid A biosynthetic process
FEZ30_07310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FEZ30_07315	COG1064	alcohol dehydrogenase
FEZ30_07340	COG0726	polysaccharide deacetylase
FEZ30_07370	COG2326	polyphosphate kinase activity
FEZ30_07375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FEZ30_07390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FEZ30_07395	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FEZ30_07405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FEZ30_07410	COG0531	amino acid
FEZ30_07415	COG0569	domain protein
FEZ30_07435	COG0756	dUTP diphosphatase activity
FEZ30_07480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FEZ30_07500	COG0187	DNA topoisomerase II activity
FEZ30_07515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FEZ30_07525	COG1643	Atp-dependent helicase
FEZ30_07545	COG0717	Belongs to the dCTP deaminase family
FEZ30_07550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FEZ30_07555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FEZ30_07570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FEZ30_07575	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FEZ30_07580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FEZ30_07590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FEZ30_07595	COG2017	converts alpha-aldose to the beta-anomer
FEZ30_07600	COG1418	mRNA catabolic process
FEZ30_07605	COG2137	regulation of response to DNA damage stimulus
FEZ30_07620	COG1349	DNA-binding transcription factor activity
FEZ30_07630	COG1058	Belongs to the CinA family
FEZ30_07630	COG1546	Belongs to the CinA family
FEZ30_07640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FEZ30_07670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FEZ30_07675	COG0284	orotidine-5'-phosphate decarboxylase activity
FEZ30_07680	COG0167	dihydroorotate dehydrogenase activity
FEZ30_07685	COG0543	2 iron, 2 sulfur cluster binding
FEZ30_07690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FEZ30_07695	COG0505	Belongs to the CarA family
FEZ30_07700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FEZ30_07715	COG0667	Aldo Keto reductase
FEZ30_07725	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FEZ30_07740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FEZ30_07750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FEZ30_07755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FEZ30_07780	COG2304	oxidoreductase activity
FEZ30_07790	COG0714	Associated with various cellular activities
FEZ30_07820	COG0477	Major facilitator Superfamily
FEZ30_07830	COG0515	serine threonine protein kinase
FEZ30_07855	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FEZ30_07865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEZ30_07885	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FEZ30_07910	COG1191	sigma factor activity
FEZ30_07915	COG0358	DNA primase activity
FEZ30_07920	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FEZ30_07950	COG1053	succinate dehydrogenase
FEZ30_07960	COG0076	glutamate decarboxylase activity
FEZ30_07970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FEZ30_07975	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FEZ30_07985	COG0423	glycine-tRNA ligase activity
FEZ30_07995	COG0735	belongs to the Fur family
FEZ30_08025	COG0667	Aldo Keto reductase
FEZ30_08030	COG4716	Myosin-crossreactive antigen
FEZ30_08040	COG1381	Involved in DNA repair and RecF pathway recombination
FEZ30_08045	COG1404	Belongs to the peptidase S8 family
FEZ30_08055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FEZ30_08065	COG0765	amino acid transport
FEZ30_08070	COG0765	amino acid transport
FEZ30_08075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FEZ30_08080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FEZ30_08090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FEZ30_08100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FEZ30_08120	COG2226	methyltransferase
FEZ30_08135	COG0596	Alpha beta hydrolase
FEZ30_08160	COG4152	abc transporter atp-binding protein
FEZ30_08165	COG2197	response regulator
FEZ30_08175	COG0343	queuine tRNA-ribosyltransferase activity
FEZ30_08180	COG5006	permease, DMT superfamily
FEZ30_08185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FEZ30_08200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEZ30_08200	COG2213	PTS system mannitol-specific
FEZ30_08205	COG1063	alcohol dehydrogenase
FEZ30_08215	COG0484	heat shock protein binding
FEZ30_08220	COG1420	regulation of RNA biosynthetic process
FEZ30_08240	COG0483	inositol monophosphate 1-phosphatase activity
FEZ30_08260	COG1175	transmembrane transport
FEZ30_08265	COG0395	ABC-type sugar transport system, permease component
FEZ30_08275	COG0477	Major facilitator Superfamily
FEZ30_08280	COG1309	transcriptional regulator
FEZ30_08285	COG1131	(ABC) transporter
FEZ30_08295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FEZ30_08300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FEZ30_08310	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FEZ30_08320	COG1169	isochorismate synthase
FEZ30_08330	COG4948	Mandelate Racemase Muconate Lactonizing
FEZ30_08365	COG0268	Binds directly to 16S ribosomal RNA
FEZ30_08375	COG1061	Type III restriction enzyme res subunit
FEZ30_08380	COG0658	competence protein
FEZ30_08380	COG2333	competence protein COMEC
FEZ30_08390	COG0495	leucyl-tRNA aminoacylation
FEZ30_08405	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FEZ30_08410	COG1063	alcohol dehydrogenase
FEZ30_08415	COG0590	tRNA wobble adenosine to inosine editing
FEZ30_08485	COG0488	(ABC) transporter
FEZ30_08525	COG1280	lysine exporter protein (LysE YggA)
FEZ30_08550	COG1484	DNA-dependent DNA replication
FEZ30_08570	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FEZ30_08580	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FEZ30_08615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FEZ30_08620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FEZ30_08625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FEZ30_08630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FEZ30_08645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FEZ30_08650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FEZ30_08655	COG1530	ribonuclease E activity
FEZ30_08665	COG1472	Belongs to the glycosyl hydrolase 3 family
FEZ30_08675	COG0105	UTP biosynthetic process
FEZ30_08685	COG0285	dihydrofolate synthase activity
FEZ30_08695	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FEZ30_08700	COG0149	triose-phosphate isomerase activity
FEZ30_08705	COG0126	phosphoglycerate kinase activity
FEZ30_08710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FEZ30_08715	COG1481	regulation of sporulation
FEZ30_08720	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FEZ30_08725	COG1660	Displays ATPase and GTPase activities
FEZ30_08730	COG0322	excinuclease ABC activity
FEZ30_08750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FEZ30_08765	COG0556	nucleotide-excision repair
FEZ30_08775	COG0237	dephospho-CoA kinase activity
FEZ30_08780	COG0539	negative regulation of cytoplasmic translation
FEZ30_08805	COG2050	protein possibly involved in aromatic compounds catabolism
FEZ30_08820	COG0469	pyruvate kinase activity
FEZ30_08835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FEZ30_08850	COG1799	cell septum assembly
FEZ30_08860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FEZ30_08870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FEZ30_08875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FEZ30_08880	COG0772	Belongs to the SEDS family
FEZ30_08885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FEZ30_08890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FEZ30_08895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FEZ30_08905	COG0768	penicillin binding
FEZ30_08915	COG0275	rRNA processing
FEZ30_08920	COG2001	Belongs to the MraZ family
FEZ30_08925	COG0714	Associated with various cellular activities
FEZ30_08945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FEZ30_08950	COG0509	glycine decarboxylation via glycine cleavage system
FEZ30_08955	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FEZ30_08955	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FEZ30_08960	COG1131	(ABC) transporter
FEZ30_08980	COG3265	gluconokinase activity
FEZ30_08990	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FEZ30_09000	COG0596	Alpha beta hydrolase
FEZ30_09005	COG1116	anion transmembrane transporter activity
FEZ30_09005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FEZ30_09025	COG0210	DNA helicase
FEZ30_09030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FEZ30_09040	COG0352	thiamine-phosphate diphosphorylase activity
FEZ30_09050	COG2815	serine threonine protein kinase
FEZ30_09050	COG0515	serine threonine protein kinase
FEZ30_09065	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FEZ30_09070	COG2197	response regulator
FEZ30_09090	COG1940	carbohydrate kinase activity
FEZ30_09135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FEZ30_09145	COG1845	cytochrome c oxidase, subunit III
FEZ30_09155	COG0723	plastoquinol--plastocyanin reductase activity
FEZ30_09160	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FEZ30_09180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FEZ30_09185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FEZ30_09235	COG0321	lipoyl(octanoyl) transferase activity
FEZ30_09250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FEZ30_09260	COG0488	(ABC) transporter
FEZ30_09265	COG2239	Acts as a magnesium transporter
FEZ30_09270	COG0586	Pfam SNARE associated Golgi protein
FEZ30_09290	COG0174	glutamine synthetase
FEZ30_09300	COG3093	addiction module antidote protein HigA
FEZ30_09310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FEZ30_09320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FEZ30_09345	COG0598	Magnesium transport protein CorA
FEZ30_09365	COG0531	amino acid
FEZ30_09370	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FEZ30_09420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FEZ30_09425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FEZ30_09450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FEZ30_09455	COG0297	glycogen (starch) synthase activity
FEZ30_09470	COG1611	Belongs to the LOG family
FEZ30_09480	COG2171	N-acyltransferase activity
FEZ30_09505	COG2720	vancomycin resistance protein
FEZ30_09510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FEZ30_09515	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FEZ30_09520	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FEZ30_09525	COG2814	Major facilitator Superfamily
FEZ30_09560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FEZ30_09570	COG0647	UMP catabolic process
FEZ30_09580	COG0698	ribose 5-phosphate isomerase
FEZ30_09585	COG1349	DNA-binding transcription factor activity
FEZ30_09590	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FEZ30_09595	COG2376	Dihydroxyacetone kinase
FEZ30_09600	COG1063	alcohol dehydrogenase
FEZ30_09605	COG1012	belongs to the aldehyde dehydrogenase family
FEZ30_09625	COG1121	(ABC) transporter
FEZ30_09630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FEZ30_09660	COG0765	amino acid transport
FEZ30_09665	COG1126	abc transporter atp-binding protein
FEZ30_09680	COG2501	S4 domain
FEZ30_09715	COG0833	amino acid
FEZ30_09730	COG2133	pyrroloquinoline quinone binding
FEZ30_09735	COG2716	regulation of RNA biosynthetic process
FEZ30_09760	COG0477	Major facilitator Superfamily
FEZ30_09765	COG0477	Major facilitator Superfamily
FEZ30_09770	COG1028	Short-chain dehydrogenase reductase Sdr
FEZ30_09770	COG0604	alcohol dehydrogenase
FEZ30_09770	COG3321	synthase
FEZ30_09795	COG1335	isochorismatase
FEZ30_09800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FEZ30_09820	COG0406	alpha-ribazole phosphatase activity
FEZ30_09825	COG1132	(ABC) transporter
FEZ30_09930	COG0012	GTP binding
FEZ30_09950	COG1362	aminopeptidase activity
FEZ30_09955	COG1322	Protein conserved in bacteria
FEZ30_09960	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FEZ30_09965	COG1570	exodeoxyribonuclease VII activity
FEZ30_09970	COG1722	exodeoxyribonuclease VII activity
FEZ30_09980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FEZ30_09990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FEZ30_09995	COG1331	Highly conserved protein containing a thioredoxin domain
FEZ30_10010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FEZ30_10025	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FEZ30_10030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FEZ30_10065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FEZ30_10080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FEZ30_10085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FEZ30_10085	COG0072	phenylalanine-tRNA ligase activity
FEZ30_10090	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FEZ30_10100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FEZ30_10105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FEZ30_10110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FEZ30_10115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FEZ30_10170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FEZ30_10175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FEZ30_10180	COG2837	iron assimilation
FEZ30_10210	COG0148	phosphopyruvate hydratase activity
FEZ30_10230	COG0193	aminoacyl-tRNA hydrolase activity
FEZ30_10235	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FEZ30_10240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FEZ30_10245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FEZ30_10255	COG1309	transcriptional regulator
FEZ30_10260	COG1846	Transcriptional regulator
FEZ30_10265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FEZ30_10270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FEZ30_10275	COG0084	hydrolase, TatD family'
FEZ30_10290	COG2233	PERMEase
FEZ30_10300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FEZ30_10305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FEZ30_10365	COG0693	protein deglycase activity
FEZ30_10375	COG0789	Transcriptional regulator
FEZ30_10405	COG1053	succinate dehydrogenase
FEZ30_10430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FEZ30_10500	COG2409	Drug exporters of the RND superfamily
FEZ30_10580	COG4974	Belongs to the 'phage' integrase family
FEZ30_10885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FEZ30_10900	COG1970	mechanosensitive ion channel activity
FEZ30_10915	COG2801	Transposase and inactivated derivatives
FEZ30_10925	COG0673	inositol 2-dehydrogenase activity
FEZ30_10930	COG2814	Major facilitator Superfamily
FEZ30_10935	COG0673	inositol 2-dehydrogenase activity
FEZ30_10940	COG1609	Transcriptional regulator
FEZ30_10950	COG3962	Belongs to the TPP enzyme family
FEZ30_10955	COG3718	enzyme involved in inositol metabolism
FEZ30_10965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FEZ30_10970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FEZ30_10975	COG3118	belongs to the thioredoxin family
FEZ30_10980	COG2226	methyltransferase
FEZ30_10985	COG1321	iron dependent repressor
FEZ30_11010	COG2252	PERMEase
FEZ30_11025	COG1278	Cold shock
FEZ30_11030	COG0363	glucosamine-6-phosphate deaminase activity
FEZ30_11075	COG0459	protein refolding
FEZ30_11085	COG1482	cell wall glycoprotein biosynthetic process
FEZ30_11090	COG1854	S-ribosylhomocysteine lyase activity
FEZ30_11155	COG4974	Belongs to the 'phage' integrase family
FEZ30_11185	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FEZ30_11195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FEZ30_11195	COG1648	precorrin-2 dehydrogenase activity
FEZ30_11200	COG1797	cobyrinic acid a,c-diamide synthase activity
FEZ30_11205	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FEZ30_11230	COG0310	cobalt ion transport
FEZ30_11245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FEZ30_11245	COG1648	precorrin-2 dehydrogenase activity
FEZ30_11265	COG1492	cobalamin metabolic process
FEZ30_11270	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FEZ30_11275	COG2197	response regulator
FEZ30_11280	COG4585	Histidine kinase
FEZ30_11285	COG1131	(ABC) transporter
FEZ30_11300	COG0406	alpha-ribazole phosphatase activity
FEZ30_11310	COG2197	response regulator
FEZ30_11315	COG4585	Histidine kinase
FEZ30_11325	COG1131	(ABC) transporter
FEZ30_11330	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FEZ30_11340	COG0156	8-amino-7-oxononanoate synthase activity
FEZ30_11345	COG1063	alcohol dehydrogenase
FEZ30_11350	COG0395	ABC-type sugar transport system, permease component
FEZ30_11355	COG1175	transmembrane transport
FEZ30_11360	COG1653	transport
FEZ30_11365	COG1940	carbohydrate kinase activity
FEZ30_11370	COG1760	l-serine dehydratase
FEZ30_11380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEZ30_11395	COG2801	Transposase and inactivated derivatives
FEZ30_11400	COG3842	ATPase activity
FEZ30_11445	COG0626	cystathionine gamma-synthase activity
FEZ30_11460	COG0215	cysteine-tRNA ligase activity
FEZ30_11465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FEZ30_11475	COG2814	Major facilitator Superfamily
FEZ30_11480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FEZ30_11500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FEZ30_11505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FEZ30_11520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FEZ30_11530	COG3775	system Galactitol-specific IIC component
FEZ30_11540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEZ30_11545	COG1329	Transcriptional regulator
FEZ30_11560	COG5002	protein histidine kinase activity
FEZ30_11565	COG0704	Plays a role in the regulation of phosphate uptake
FEZ30_11570	COG0588	phosphoglycerate mutase activity
FEZ30_11575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEZ30_11610	COG0191	fructose-bisphosphate aldolase activity
FEZ30_11625	COG0586	Pfam SNARE associated Golgi protein
FEZ30_11645	COG0489	protein tyrosine kinase activity
FEZ30_11650	COG2244	polysaccharide biosynthetic process
FEZ30_11660	COG0438	transferase activity, transferring glycosyl groups
FEZ30_11670	COG0438	transferase activity, transferring glycosyl groups
FEZ30_11690	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FEZ30_11690	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FEZ30_11695	COG1704	LemA family
FEZ30_11715	COG0436	Aminotransferase
FEZ30_11730	COG1174	glycine betaine transport
FEZ30_11740	COG1174	glycine betaine transport
FEZ30_11755	COG1131	(ABC) transporter
FEZ30_11760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEZ30_11770	COG4176	ABC-type proline glycine betaine transport system permease component
FEZ30_11780	COG3012	SEC-C Motif Domain Protein
FEZ30_11810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FEZ30_11820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FEZ30_11840	COG0702	epimerase
FEZ30_11845	COG1309	transcriptional regulator
FEZ30_11855	COG1511	domain protein
FEZ30_11870	COG1486	melibiose metabolic process
FEZ30_11880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FEZ30_11890	COG1175	transmembrane transport
FEZ30_11895	COG0395	ABC-type sugar transport system, permease component
FEZ30_11900	COG0542	response to heat
FEZ30_11910	COG0395	ABC-type sugar transport system, permease component
FEZ30_11925	COG3588	fructose-bisphosphate aldolase
FEZ30_11950	COG4585	Histidine kinase
FEZ30_11955	COG2197	response regulator
FEZ30_11965	COG1136	(ABC) transporter
FEZ30_11965	COG4591	ABC-type transport system involved in lipoprotein release permease component
FEZ30_11970	COG0577	efflux transmembrane transporter activity
FEZ30_11970	COG1136	(ABC) transporter
FEZ30_11980	COG1113	amino acid transport
FEZ30_11985	COG0569	domain protein
FEZ30_11985	COG2985	domain, Protein
FEZ30_11990	COG3527	Alpha-acetolactate decarboxylase
FEZ30_11995	COG1063	alcohol dehydrogenase
FEZ30_12000	COG0789	Transcriptional regulator
FEZ30_12005	COG0484	heat shock protein binding
FEZ30_12010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FEZ30_12030	COG0745	RESPONSE REGULATOR receiver
FEZ30_12035	COG2205	protein histidine kinase activity
FEZ30_12040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FEZ30_12055	COG0574	Belongs to the PEP-utilizing enzyme family
FEZ30_12055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FEZ30_12060	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FEZ30_12065	COG2813	Specifically methylates the guanine in position
FEZ30_12070	COG0560	Phosphoserine phosphatase
FEZ30_12070	COG3830	Belongs to the UPF0237 family
FEZ30_12090	COG1309	transcriptional regulator
FEZ30_12095	COG1131	(ABC) transporter
FEZ30_12110	COG4608	Belongs to the ABC transporter superfamily
FEZ30_12115	COG0154	amidase activity
FEZ30_12155	COG1027	Aspartate ammonia-lyase
FEZ30_12165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FEZ30_12185	COG0673	inositol 2-dehydrogenase activity
FEZ30_12195	COG1609	Transcriptional regulator
FEZ30_12235	COG1609	Transcriptional regulator
FEZ30_12240	COG3254	rhamnose metabolic process
FEZ30_12245	COG2814	Major facilitator Superfamily
FEZ30_12250	COG4952	isomerase
FEZ30_12255	COG1070	Carbohydrate kinase
FEZ30_12265	COG1012	belongs to the aldehyde dehydrogenase family
FEZ30_12280	COG2814	Major facilitator Superfamily
FEZ30_12300	COG0018	arginyl-trna synthetase
FEZ30_12305	COG0656	L-ascorbic acid biosynthetic process
FEZ30_12310	COG2814	Major facilitator Superfamily
FEZ30_12330	COG0166	Belongs to the GPI family
FEZ30_12340	COG4581	dead DEAH box helicase
FEZ30_12350	COG1881	PFAM PEBP family protein
FEZ30_12370	COG0667	Aldo Keto reductase
FEZ30_12380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FEZ30_12385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FEZ30_12395	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FEZ30_12405	COG0583	DNA-binding transcription factor activity
FEZ30_12410	COG2814	Major facilitator Superfamily
FEZ30_12415	COG0861	Integral membrane protein TerC family
FEZ30_12450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FEZ30_12455	COG0561	phosphatase activity
FEZ30_12460	COG0561	phosphatase activity
FEZ30_12475	COG0577	efflux transmembrane transporter activity
FEZ30_12475	COG1136	(ABC) transporter
FEZ30_12500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FEZ30_12505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FEZ30_12550	COG1131	(ABC) transporter
FEZ30_12555	COG1309	transcriptional regulator
FEZ30_12570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FEZ30_12575	COG1695	Transcriptional regulator
FEZ30_12580	COG0477	Major facilitator Superfamily
FEZ30_12625	COG1316	TRANSCRIPTIONal
FEZ30_12650	COG0604	alcohol dehydrogenase
FEZ30_12665	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FEZ30_12670	COG1088	dTDP-glucose 4,6-dehydratase activity
FEZ30_12680	COG1716	ATPase activity
FEZ30_12685	COG1716	ATPase activity
FEZ30_12700	COG0768	penicillin binding
FEZ30_12705	COG0515	serine threonine protein kinase
FEZ30_12725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FEZ30_12730	COG0393	Putative heavy-metal-binding
FEZ30_12740	COG1953	Uracil, thiamine, allantoin
FEZ30_12745	COG1301	dicarboxylic acid transport
FEZ30_12750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FEZ30_12755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FEZ30_12775	COG2186	Transcriptional regulator
FEZ30_12780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FEZ30_12785	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FEZ30_12810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEZ30_12830	COG1609	Transcriptional regulator
FEZ30_12840	COG0395	ABC-type sugar transport system, permease component
FEZ30_12845	COG1653	transport
FEZ30_12855	COG1454	alcohol dehydrogenase
FEZ30_12860	COG2814	Major facilitator Superfamily
FEZ30_12890	COG1271	oxidase subunit
FEZ30_12895	COG1294	oxidase, subunit
FEZ30_12900	COG4988	ABC transporter
FEZ30_12905	COG1132	(ABC) transporter
FEZ30_12915	COG1556	Lactate utilization protein
FEZ30_12920	COG1139	Iron-sulfur cluster binding protein
FEZ30_12925	COG0247	lactate metabolic process
FEZ30_12930	COG1620	l-lactate permease
FEZ30_12935	COG2186	Transcriptional regulator
FEZ30_12950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FEZ30_12950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FEZ30_12950	COG0674	pyruvate-flavodoxin oxidoreductase activity
FEZ30_12950	COG1013	pyruvate-flavodoxin oxidoreductase activity
FEZ30_12955	COG0167	dihydroorotate dehydrogenase activity
FEZ30_12970	COG1083	cytidylyl-transferase
FEZ30_12975	COG2089	acid synthase
FEZ30_12985	COG1215	transferase activity, transferring glycosyl groups
FEZ30_12995	COG0463	Glycosyl transferase, family 2
FEZ30_13000	COG1132	(ABC) transporter
FEZ30_13055	COG0489	protein tyrosine kinase activity
FEZ30_13075	COG1316	TRANSCRIPTIONal
FEZ30_13100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FEZ30_13115	COG1937	Protein conserved in bacteria
FEZ30_13120	COG0305	Participates in initiation and elongation during chromosome replication
FEZ30_13125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FEZ30_13125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FEZ30_13135	COG3118	belongs to the thioredoxin family
FEZ30_13145	COG0386	Belongs to the glutathione peroxidase family
FEZ30_13150	COG1846	Transcriptional regulator
FEZ30_13170	COG2094	Belongs to the DNA glycosylase MPG family
FEZ30_13185	COG1643	Atp-dependent helicase
FEZ30_13200	COG2897	thiosulfate sulfurtransferase activity
FEZ30_13260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FEZ30_13265	COG1126	abc transporter atp-binding protein
FEZ30_13270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FEZ30_13275	COG0765	amino acid transport
FEZ30_13280	COG0765	amino acid transport
FEZ30_13290	COG1105	Belongs to the carbohydrate kinase PfkB family
FEZ30_13295	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FEZ30_13295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEZ30_13295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEZ30_13325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FEZ30_13365	COG0438	transferase activity, transferring glycosyl groups
FEZ30_13370	COG0438	transferase activity, transferring glycosyl groups
FEZ30_13385	COG0463	Glycosyl transferase, family 2
FEZ30_13470	COG2072	flavoprotein involved in K transport
FEZ30_13500	COG1253	flavin adenine dinucleotide binding
FEZ30_13530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FEZ30_13545	COG1063	alcohol dehydrogenase
FEZ30_13550	COG0586	Pfam SNARE associated Golgi protein
FEZ30_13560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FEZ30_13570	COG1119	ATPase activity
FEZ30_13590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FEZ30_13595	COG1414	Transcriptional regulator
FEZ30_13600	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FEZ30_13605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FEZ30_13610	COG0402	S-adenosylhomocysteine deaminase activity
FEZ30_13615	COG1228	amidohydrolase
FEZ30_13640	COG1609	Transcriptional regulator
FEZ30_13645	COG0673	inositol 2-dehydrogenase activity
FEZ30_13655	COG2186	Transcriptional regulator
FEZ30_13665	COG5564	TIM-barrel signal transduction protein
FEZ30_13695	COG2211	Major facilitator Superfamily
FEZ30_13740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FEZ30_13785	COG2826	transposase and inactivated derivatives, IS30 family
FEZ30_13790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FEZ30_13835	COG1609	Transcriptional regulator
FEZ30_13840	COG2271	Major facilitator Superfamily
FEZ30_13865	COG1309	transcriptional regulator
FEZ30_13875	COG1904	glucuronate isomerase
FEZ30_13880	COG2721	sulfolactate sulfo-lyase activity
FEZ30_13890	COG1609	Transcriptional regulator
FEZ30_13895	COG1414	Transcriptional regulator
FEZ30_13900	COG0800	Aldolase
FEZ30_13905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FEZ30_13910	COG1482	cell wall glycoprotein biosynthetic process
FEZ30_13920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FEZ30_13940	COG3119	arylsulfatase activity
FEZ30_13960	COG1070	Carbohydrate kinase
FEZ30_13980	COG1201	RNA secondary structure unwinding
FEZ30_14030	COG3311	Transcriptional regulator
FEZ30_14045	COG1401	restriction endodeoxyribonuclease activity
FEZ30_14080	COG0584	glycerophosphoryl diester phosphodiesterase
FEZ30_14085	COG1609	Transcriptional regulator
FEZ30_14095	COG1285	pathogenesis
FEZ30_14115	COG4948	Mandelate Racemase Muconate Lactonizing
FEZ30_14125	COG0656	L-ascorbic acid biosynthetic process
FEZ30_14135	COG1312	Catalyzes the dehydration of D-mannonate
FEZ30_14140	COG0246	Mannitol dehydrogenase
FEZ30_14145	COG1904	glucuronate isomerase
FEZ30_14165	COG1012	belongs to the aldehyde dehydrogenase family
FEZ30_14225	COG3386	PFAM SMP-30 Gluconolaconase
FEZ30_14230	COG0352	thiamine-phosphate diphosphorylase activity
FEZ30_14235	COG0352	thiamine-phosphate diphosphorylase activity
FEZ30_14235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FEZ30_14235	COG0351	phosphomethylpyrimidine kinase
FEZ30_14240	COG2364	Membrane
FEZ30_14250	COG0315	cyclic pyranopterin monophosphate synthase activity
FEZ30_14260	COG0314	molybdopterin synthase activity
FEZ30_14270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FEZ30_14290	COG1140	nitrate reductase beta subunit
FEZ30_14315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FEZ30_14320	COG0543	2 iron, 2 sulfur cluster binding
FEZ30_14320	COG0633	Ferredoxin
FEZ30_14325	COG1151	hydroxylamine reductase activity
FEZ30_14335	COG2337	Toxic component of a toxin-antitoxin (TA) module
FEZ30_14365	COG0601	transmembrane transport
FEZ30_14385	COG0435	Glutathione S-transferase
FEZ30_14400	COG0456	acetyltransferase
FEZ30_14425	COG1484	DNA-dependent DNA replication
FEZ30_14495	COG0783	Belongs to the Dps family
FEZ30_14500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FEZ30_14510	COG2217	Heavy metal translocating P-type atpase
FEZ30_14520	COG3189	MarR family transcriptional regulator
FEZ30_14560	COG0205	6-phosphofructokinase activity
FEZ30_14585	COG1136	(ABC) transporter
FEZ30_14585	COG0577	efflux transmembrane transporter activity
FEZ30_14595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FEZ30_14605	COG0511	ligase activity, forming carbon-carbon bonds
FEZ30_14605	COG5016	pyruvate
FEZ30_14615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FEZ30_14620	COG0045	succinate-CoA ligase (ADP-forming) activity
FEZ30_14625	COG1254	Belongs to the acylphosphatase family
FEZ30_14645	COG0281	malic enzyme
FEZ30_14655	COG1321	iron dependent repressor
FEZ30_14655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FEZ30_14660	COG1914	H( )-stimulated, divalent metal cation uptake system
FEZ30_14665	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FEZ30_14670	COG0477	Major facilitator Superfamily
FEZ30_14680	COG2814	Major facilitator Superfamily
FEZ30_14690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FEZ30_14695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FEZ30_14705	COG0438	transferase activity, transferring glycosyl groups
FEZ30_14715	COG2409	Drug exporters of the RND superfamily
FEZ30_14720	COG1309	transcriptional regulator
FEZ30_14740	COG2022	thiamine diphosphate biosynthetic process
FEZ30_14755	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FEZ30_14790	COG0656	L-ascorbic acid biosynthetic process
FEZ30_14800	COG1473	amidohydrolase
FEZ30_14815	COG0730	response to heat
FEZ30_14830	COG0175	sulfate reduction
FEZ30_14855	COG2132	Multicopper oxidase
FEZ30_14865	COG0745	RESPONSE REGULATOR receiver
FEZ30_14870	COG5002	protein histidine kinase activity
FEZ30_14885	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FEZ30_14890	COG2205	protein histidine kinase activity
FEZ30_14900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FEZ30_14925	COG1132	(ABC) transporter
FEZ30_14930	COG0477	Major facilitator Superfamily
FEZ30_14935	COG1690	Belongs to the RtcB family
FEZ30_14940	COG3657	addiction module killer protein
FEZ30_14945	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FEZ30_14960	COG2197	response regulator
FEZ30_14965	COG1136	(ABC) transporter
FEZ30_14990	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FEZ30_15015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FEZ30_15025	COG1012	belongs to the aldehyde dehydrogenase family
FEZ30_15090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FEZ30_15110	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FEZ30_15120	COG1175	transmembrane transport
FEZ30_15135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FEZ30_15140	COG1126	abc transporter atp-binding protein
FEZ30_15145	COG0765	amino acid transport
FEZ30_15150	COG0148	phosphopyruvate hydratase activity
FEZ30_15155	COG0095	Lipoate-protein ligase
FEZ30_15165	COG1131	(ABC) transporter
FEZ30_15185	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FEZ30_15190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FEZ30_15200	COG3775	system Galactitol-specific IIC component
FEZ30_15205	COG3414	Phosphotransferase system galactitol-specific IIB component
FEZ30_15210	COG1063	alcohol dehydrogenase
FEZ30_15220	COG0235	Class ii aldolase
FEZ30_15245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FEZ30_15250	COG1012	belongs to the aldehyde dehydrogenase family
FEZ30_15260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FEZ30_15265	COG0039	L-malate dehydrogenase activity
FEZ30_15270	COG0281	malic enzyme
FEZ30_15285	COG0039	L-malate dehydrogenase activity
FEZ30_15315	COG2801	Transposase and inactivated derivatives
FEZ30_15330	COG1396	sequence-specific DNA binding
FEZ30_15335	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
FEZ30_15345	COG1028	Short-chain dehydrogenase reductase Sdr
FEZ30_15370	COG1869	D-ribose catabolic process
FEZ30_15375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FEZ30_15380	COG1879	ABC-type sugar transport system periplasmic component
FEZ30_15385	COG1172	Belongs to the binding-protein-dependent transport system permease family
FEZ30_15390	COG1129	ABC transporter
FEZ30_15395	COG1609	Transcriptional regulator
FEZ30_15405	COG3266	domain, Protein
FEZ30_15410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FEZ30_15415	COG0187	DNA topoisomerase II activity
FEZ30_15425	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FEZ30_15430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FEZ30_15440	COG0592	DNA-directed DNA polymerase activity
FEZ30_15445	COG1136	(ABC) transporter
FEZ30_15445	COG0577	efflux transmembrane transporter activity
FEZ30_15450	COG1136	(ABC) transporter
FEZ30_15450	COG0577	efflux transmembrane transporter activity
FEZ30_15455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FEZ30_15465	COG0594	ribonuclease P activity
FEZ30_15475	COG0706	membrane insertase activity
FEZ30_15485	COG2076	Multidrug Resistance protein
FEZ30_15490	COG0357	Ribosomal RNA small subunit methyltransferase G
FEZ30_15500	COG1192	Involved in chromosome partitioning
FEZ30_15510	COG1793	dna ligase
FEZ30_15510	COG3285	dna ligase
FEZ30_15525	COG1181	Belongs to the D-alanine--D-alanine ligase family
FEZ30_15530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEZ30_15555	COG0673	inositol 2-dehydrogenase activity
FEZ30_15560	COG1082	Xylose isomerase domain protein TIM barrel
FEZ30_15570	COG2814	Major facilitator Superfamily
FEZ30_15575	COG1609	Transcriptional regulator
FEZ30_15595	COG0673	inositol 2-dehydrogenase activity
FEZ30_15600	COG1082	Xylose isomerase domain protein TIM barrel
FEZ30_15605	COG2855	membrane
FEZ30_15615	COG1609	Transcriptional regulator
FEZ30_15620	COG0673	inositol 2-dehydrogenase activity
FEZ30_15625	COG1082	Xylose isomerase domain protein TIM barrel
FEZ30_15655	COG4585	Histidine kinase
FEZ30_15690	COG5433	transposase activity
FEZ30_15765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FEZ30_15785	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FEZ30_15800	COG1660	Displays ATPase and GTPase activities
FEZ30_15815	COG0626	cystathionine gamma-synthase activity
FEZ30_15830	COG2124	cytochrome p450
FEZ30_15845	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FEZ30_15895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FEZ30_15920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FEZ30_15970	COG0564	pseudouridine synthase activity
FEZ30_15980	COG1733	regulation of RNA biosynthetic process
FEZ30_15990	COG1609	Transcriptional regulator
FEZ30_16010	COG0395	ABC-type sugar transport system, permease component
FEZ30_16025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FEZ30_16035	COG2390	Transcriptional regulator
FEZ30_16040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FEZ30_16045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FEZ30_16055	COG1595	DNA-templated transcription, initiation
FEZ30_16075	COG0385	Bile acid
FEZ30_16080	COG1012	belongs to the aldehyde dehydrogenase family
FEZ30_16100	COG0668	transmembrane transport
FEZ30_16115	COG0540	Belongs to the ATCase OTCase family
FEZ30_16120	COG1349	DNA-binding transcription factor activity
FEZ30_16145	COG1131	(ABC) transporter
FEZ30_16165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FEZ30_16170	COG0114	fumarate hydratase activity
FEZ30_16180	COG3830	Belongs to the UPF0237 family
FEZ30_16185	COG2848	UPF0210 protein
FEZ30_16235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FEZ30_16245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FEZ30_16290	COG2267	carboxylic ester hydrolase activity
FEZ30_16295	COG0686	Belongs to the AlaDH PNT family
FEZ30_16300	COG0205	6-phosphofructokinase activity
FEZ30_16315	COG0515	serine threonine protein kinase
FEZ30_16320	COG1716	ATPase activity
FEZ30_16320	COG1131	(ABC) transporter
FEZ30_16320	COG0842	Transport permease protein
FEZ30_16330	COG2146	nitrite reductase [NAD(P)H] activity
FEZ30_16345	COG3609	addiction module antidote protein, CC2985 family
FEZ30_16350	COG2337	Toxic component of a toxin-antitoxin (TA) module
FEZ30_16380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FEZ30_16405	COG1175	transmembrane transport
FEZ30_16415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FEZ30_16425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FEZ30_16440	COG0534	Mate efflux family protein
FEZ30_16530	COG1113	amino acid transport
FEZ30_16540	COG1846	Transcriptional regulator
FEZ30_16545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FEZ30_16550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FEZ30_16555	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
FEZ30_16560	COG0247	lactate metabolic process
FEZ30_16565	COG4585	Histidine kinase
FEZ30_16570	COG0577	efflux transmembrane transporter activity
FEZ30_16570	COG1136	(ABC) transporter
FEZ30_16590	COG2801	Transposase and inactivated derivatives
FEZ30_16600	COG1131	(ABC) transporter
FEZ30_16605	COG1051	belongs to the nudix hydrolase family
FEZ30_16610	COG2197	response regulator
FEZ30_16620	COG0277	FAD linked oxidase domain protein