locus-tag class description DUY81_00075 ENOG4105D2H Uronic isomerase DUY81_00080 ENOG4105CTX dehydratase DUY81_00085 ENOG4107QZW Altronate oxidoreductase DUY81_00090 ENOG4105ETE Transcriptional regulator (LacI family DUY81_00095 ENOG4108FUF Transcriptional regulator, IclR family DUY81_00100 ENOG4108UHU Aldolase DUY81_00105 ENOG4105D7K pfkb domain protein DUY81_00110 ENOG4105EIP mannose-6-phosphate isomerase DUY81_00120 ENOG4105C8Y Acetylornithine aminotransferase DUY81_00170 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DUY81_00175 ENOG4105BZ7 extracellular solute-binding protein family 1 DUY81_00180 ENOG4107T6V glycerophosphoryl diester phosphodiesterase DUY81_00185 ENOG4105ETE Transcriptional regulator (LacI family DUY81_00195 ENOG4105KT7 mgtC SapB transporter DUY81_00215 ENOG4105DTQ mandelate racemase muconate lactonizing DUY81_00235 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) DUY81_00240 ENOG4105DEI Mannitol dehydrogenase DUY81_00245 ENOG4105D2H Uronic isomerase DUY81_00250 ENOG4105ETE Transcriptional regulator (LacI family DUY81_00260 ENOG4105C26 Dehydrogenase DUY81_00270 ENOG4105DZW Dipeptidase DUY81_00285 ENOG41068JE domain protein DUY81_00300 ENOG4105C2J ABC transporter DUY81_00320 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis DUY81_00325 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DUY81_00330 ENOG4105DWF phosphomethylpyrimidine kinase DUY81_00335 ENOG4108VW9 Membrane DUY81_00340 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DUY81_00345 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DUY81_00355 ENOG4108ZAF Molybdopterin DUY81_00365 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DUY81_00385 ENOG4108IUE nitrate reductase beta subunit DUY81_00410 ENOG4108SQ9 flavin reductase domain protein, FMN-binding DUY81_00415 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding DUY81_00420 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DUY81_00445 ENOG4105F4R Transcriptional regulator mode DUY81_00460 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DUY81_00465 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DUY81_00470 ENOG4108JQ6 ABC transporter DUY81_00475 ENOG4108J59 Extracellular solute-binding protein, family 5 DUY81_00485 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DUY81_00510 ENOG4105F5W AtP-binding protein DUY81_00550 ENOG4105F5W AtP-binding protein DUY81_00600 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction DUY81_00605 ENOG4105DS0 Transcriptional regulator, Crp Fnr family DUY81_00615 ENOG4105C59 p-type ATPase DUY81_00625 ENOG4105K78 MarR family Transcriptional regulator DUY81_00665 ENOG4105CTQ phosphohexokinase DUY81_00690 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DUY81_00705 ENOG4105D9Q decarboxylase (Beta subunit) DUY81_00710 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein DUY81_00720 ENOG4105D8K carboxyl transferase DUY81_00725 ENOG4105CD5 CoA-binding domain protein DUY81_00730 ENOG41086YM Acylphosphatase DUY81_00750 ENOG4105C6K Malic enzyme DUY81_00765 ENOG4107RPQ ABC transporter DUY81_00770 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DUY81_00775 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) DUY81_00780 ENOG4105C0R drug resistance transporter emrb qaca subfamily DUY81_00790 ENOG4105C2C drug resistance transporter, Bcr CflA DUY81_00800 ENOG4105BZ4 penicillin-binding protein DUY81_00805 ENOG4108JQ1 Dehydrogenase DUY81_00825 ENOG4105EYF MMPL domain protein DUY81_00830 ENOG41067SE Tetr family transcriptional regulator DUY81_00850 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) DUY81_00900 ENOG4105CV8 reductase DUY81_00925 ENOG410635A Membrane DUY81_00940 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) DUY81_00965 ENOG4107R16 Multicopper oxidase DUY81_00975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DUY81_00980 ENOG4105GR3 Histidine kinase DUY81_00990 ENOG4105BZU Histidine kinase DUY81_00995 ENOG4105EDW glycosyl transferase, family 39 DUY81_01000 ENOG4105BZU Histidine kinase DUY81_01035 ENOG4105BZ1 (ABC) transporter DUY81_01045 ENOG4105E0Y RtcB Protein DUY81_01050 ENOG4105VUH addiction module killer protein DUY81_01055 ENOG4105YES addiction module antidote protein DUY81_01070 ENOG4105WH1 Two component transcriptional regulator luxr family DUY81_01075 ENOG4105C19 ABC transporter DUY81_01100 ENOG4105CKU formyltetrahydrofolate synthetase DUY81_01125 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DUY81_01135 ENOG4105C26 Dehydrogenase DUY81_01200 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DUY81_01220 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) DUY81_01225 ENOG4105I1K ABC transporter DUY81_01230 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DUY81_01245 ENOG4105CIH Imidazole acetol-phosphate transaminase DUY81_01250 ENOG4105CDA abc transporter atp-binding protein DUY81_01255 ENOG4105E5Q amino acid AbC transporter DUY81_01260 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DUY81_01265 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) DUY81_01275 ENOG4105DVE abc transporter atp-binding protein DUY81_01290 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DUY81_01295 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DUY81_01305 ENOG4105DT3 PTS system, galactitol-specific IIc component DUY81_01310 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) DUY81_01315 ENOG4105CPQ Dehydrogenase DUY81_01325 ENOG4107W7X Aldolase DUY81_01350 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DUY81_01355 ENOG4105C26 Dehydrogenase DUY81_01365 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DUY81_01370 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DUY81_01375 ENOG4105C6K Malic enzyme DUY81_01390 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DUY81_01435 ENOG4106F59 XRE family Transcriptional regulator DUY81_01440 ENOG4105XUP Phage derived protein Gp49-like (DUF891) DUY81_01450 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr DUY81_01475 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DUY81_01480 ENOG4108RVA ribokinase DUY81_01485 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DUY81_01490 ENOG4105CNN ABC, transporter DUY81_01495 ENOG4105C2J ABC transporter DUY81_01500 ENOG4105ETE Transcriptional regulator (LacI family DUY81_01510 ENOG4108ZED Transmembrane domain of unknown function (DUF3566) DUY81_01515 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DUY81_01520 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DUY81_01530 ENOG4105K7N UPF0232 protein DUY81_01535 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DUY81_01545 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DUY81_01550 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DUY81_01555 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DUY81_01560 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DUY81_01570 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DUY81_01580 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DUY81_01590 ENOG4105KPY Small multidrug resistance protein DUY81_01595 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) DUY81_01605 ENOG4107QJE Chromosome Partitioning Protein DUY81_01615 ENOG4105DQE DNA ligase DUY81_01630 ENOG4105CPF Cell wall formation (By similarity) DUY81_01635 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DUY81_01650 ENOG4105C26 Dehydrogenase DUY81_01655 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DUY81_01660 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DUY81_01665 ENOG4105F0H myo-inositol catabolism protein DUY81_01670 ENOG4107P2S Transcriptional regulator DUY81_01675 ENOG4107QNK )-transporter DUY81_01685 ENOG4107QNK )-transporter DUY81_01700 ENOG4105CK5 oxidoreductase DUY81_01705 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DUY81_01710 ENOG4107ZR7 Membrane DUY81_01720 ENOG4105ETE Transcriptional regulator (LacI family DUY81_01725 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DUY81_01730 ENOG4107QP6 Xylose isomerase domain protein TIM barrel DUY81_01740 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DUY81_01770 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DUY81_01785 ENOG4105C28 cystathionine DUY81_01795 ENOG4106A3M Cytochrome p-450 DUY81_01810 ENOG4105CVN desaturase DUY81_01830 ENOG4105EWK phytoene DUY81_01835 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DUY81_01865 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DUY81_01890 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) DUY81_01935 ENOG4105K63 Thioredoxin DUY81_01950 ENOG4105KVH Transcriptional regulator DUY81_01955 ENOG4105C3M thioredoxin reductase DUY81_01960 ENOG4105ETE Transcriptional regulator (LacI family DUY81_01980 ENOG4105DRS transport system, permease DUY81_01995 ENOG4105C0H protease DUY81_02005 ENOG4107RHR regulatoR DUY81_02010 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DUY81_02015 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DUY81_02030 ENOG4105D9P serine threonine protein kinase DUY81_02045 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DUY81_02050 ENOG4105C09 Bile acid DUY81_02055 ENOG4105C26 Dehydrogenase DUY81_02060 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate DUY81_02070 ENOG4105BZW Glycerate kinase DUY81_02080 ENOG4105D8X mechanosensitive ion channel DUY81_02095 ENOG4105CXT aspartate transcarbamylase DUY81_02100 ENOG4105E98 transcriptional regulator DeoR family DUY81_02105 ENOG4105F27 Major Facilitator DUY81_02120 ENOG4105CIG ABC transporter DUY81_02125 ENOG4105CTZ aminopeptidase c DUY81_02135 ENOG41064HX Suppressor of fused protein (SUFU) DUY81_02140 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DUY81_02145 ENOG4105C9Q fumarate hydratase class II DUY81_02160 ENOG4105CAG UPF0210 protein DUY81_02170 ENOG4105CMQ Chloride channel DUY81_02195 ENOG4105E2D ec 3.2.1.52 DUY81_02210 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DUY81_02220 ENOG4105K6T rare lipoprotein A DUY81_02265 ENOG4105E5G Alpha beta hydrolase fold DUY81_02270 ENOG4105DCF alanine dehydrogenase DUY81_02275 ENOG4105CTQ phosphohexokinase DUY81_02285 ENOG4108QVN serine threonine protein kinase DUY81_02290 ENOG4105IDI abc transporter atp-binding protein DUY81_02295 ENOG4107QZF nitrite reductase NADPH large subunit DUY81_02300 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DUY81_02315 ENOG410839S Toxic component of a toxin-antitoxin (TA) module (By similarity) DUY81_02320 ENOG4105D7K pfkb domain protein DUY81_02325 ENOG4108HKT sucrose-6-phosphate hydrolase DUY81_02340 ENOG4105CIS alcohol dehydrogenase DUY81_02345 ENOG4105KVH Transcriptional regulator DUY81_02350 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) DUY81_02365 ENOG4105ETE Transcriptional regulator (LacI family DUY81_02375 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DUY81_02385 ENOG4108Z66 YbaK ebsC protein DUY81_02395 ENOG4108TFM Kinase, PfkB family DUY81_02510 ENOG4105C85 amino acid DUY81_02520 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DUY81_02525 ENOG4105C5I Dehydrogenase DUY81_02530 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A DUY81_02535 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B DUY81_02540 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DUY81_02545 ENOG4105BZU Histidine kinase DUY81_02550 ENOG4105CQB FAD linked oxidase domain protein DUY81_02595 ENOG4108IXY short-chain dehydrogenase reductase DUY81_02610 ENOG4108IQE Amp-dependent synthetase and ligase DUY81_02630 ENOG4105DBE peroxidase DUY81_02635 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) DUY81_02645 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DUY81_02650 ENOG4105K9Q Binds to the 23S rRNA (By similarity) DUY81_02660 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DUY81_02670 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DUY81_02685 ENOG4105PGM cation diffusion facilitator family transporter DUY81_02695 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DUY81_02705 ENOG41062D9 Histidine kinase DUY81_02720 ENOG4105ETE Transcriptional regulator (LacI family DUY81_02735 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DUY81_02755 ENOG4105CIF Ornithine Cyclodeaminase DUY81_02770 ENOG4105BZ1 (ABC) transporter DUY81_02790 ENOG4105CG3 alpha amylase, catalytic region DUY81_02795 ENOG4105DRS transport system, permease DUY81_02800 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component DUY81_02810 ENOG4105DKQ ROK family DUY81_02815 ENOG4105EBR Carboxylesterase DUY81_02830 ENOG4105KT7 mgtC SapB transporter DUY81_02835 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component DUY81_02840 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DUY81_02845 ENOG4105BZ7 extracellular solute-binding protein family 1 DUY81_02855 ENOG4107QK4 glycoside hydrolase, family 3 domain protein DUY81_02880 ENOG4105CG3 alpha amylase, catalytic region DUY81_02890 ENOG4107QWR cellulase (EC 3.2.1.4) DUY81_02925 ENOG4105DSQ Nitric oxide reductase DUY81_02945 ENOG4105CSH Transporter DUY81_02950 ENOG4108HKT sucrose-6-phosphate hydrolase DUY81_02965 ENOG4105GR3 Histidine kinase DUY81_02975 ENOG4105I7V membrAne DUY81_03000 ENOG4106H3A restriction DUY81_03075 ENOG4105C5I Dehydrogenase DUY81_03080 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DUY81_03110 ENOG4108JPW Aminotransferase DUY81_03120 ENOG4105ENR peptidase, M24 DUY81_03125 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DUY81_03130 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DUY81_03135 ENOG4105CSH Transporter DUY81_03160 ENOG4107VFM Dehydrogenase DUY81_03170 ENOG4105CPP Dehydrogenase, E1 component DUY81_03175 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 DUY81_03185 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DUY81_03195 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) DUY81_03215 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DUY81_03235 ENOG4105EG2 ABC transporter, permease DUY81_03250 ENOG4105ETE Transcriptional regulator (LacI family DUY81_03255 ENOG4108K4B hydrolase DUY81_03275 ENOG4105CDH Citrulline--aspartate ligase DUY81_03305 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) DUY81_03310 ENOG4105ETE Transcriptional regulator (LacI family DUY81_03315 ENOG4108KGH TRANSCRIPTIONal DUY81_03340 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DUY81_03345 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DUY81_03350 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DUY81_03375 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DUY81_03385 ENOG4108Z6B deaminase DUY81_03420 ENOG4107S1E Beta-lactamase DUY81_03430 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component DUY81_03440 ENOG4108IJ8 ABC transporter DUY81_03445 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) DUY81_03460 ENOG4105D7A ATP-binding protein DUY81_03480 ENOG4108UMN azlc family DUY81_03510 ENOG41090U3 tautomerase DUY81_03515 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DUY81_03525 ENOG4105C29 acyl-CoA thioesterase DUY81_03530 ENOG4105CMT Dihydroxyacetone kinase DUY81_03535 ENOG4105CPQ Dehydrogenase DUY81_03540 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DUY81_03545 ENOG4105DKT Transcriptional regulator DUY81_03550 ENOG4105DQ4 alcohol dehydrogenase DUY81_03560 ENOG4105C4B ABC transporter, permease DUY81_03570 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DUY81_03575 ENOG4105ETX regulatoR DUY81_03580 ENOG4105BZU Histidine kinase DUY81_03585 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DUY81_03595 ENOG4105DQR SNARE associated Golgi DUY81_03620 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DUY81_03630 ENOG4105C5I Dehydrogenase DUY81_03645 ENOG4105DZC cytosine deaminase DUY81_03670 ENOG4105ETE Transcriptional regulator (LacI family DUY81_03680 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DUY81_03710 ENOG4105C2X Arabinose 5-phosphate isomerase DUY81_03715 ENOG4105ETE Transcriptional regulator (LacI family DUY81_03740 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) DUY81_03790 ENOG4105DFH Transport of potassium into the cell (By similarity) DUY81_03810 ENOG4105WS7 Cation transport regulator DUY81_03830 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) DUY81_03855 ENOG4107S2Z UPF0761 membrane protein DUY81_03870 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DUY81_03885 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DUY81_03895 ENOG4105DQE DNA ligase DUY81_03915 ENOG4105CH6 catalase DUY81_03920 ENOG4105WH1 Two component transcriptional regulator luxr family DUY81_03930 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) DUY81_03970 ENOG4107QI1 Mate efflux family protein DUY81_03980 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DUY81_04000 ENOG4107Z1W Fructose transport system kinase DUY81_04005 ENOG4108HMQ sugar kinase DUY81_04020 ENOG4105D1Q UPF0246 protein DUY81_04035 ENOG4108JQ7 (ABC) transporter DUY81_04040 ENOG4105C3U ABC transporter DUY81_04045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DUY81_04050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DUY81_04080 ENOG410834F Transcriptional regulator DUY81_04085 ENOG4107QK5 Homocysteine s-methyltransferase DUY81_04115 ENOG4105BZ4 penicillin-binding protein DUY81_04150 ENOG4105P8F nudix hydrolase DUY81_04240 ENOG4108I5C dEAD DEAH box helicase DUY81_04245 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DUY81_04255 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DUY81_04265 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DUY81_04270 ENOG4107QRG dna polymerase iii DUY81_04280 ENOG4105MA4 psp1 domain protein DUY81_04325 ENOG4108YYH Nadph-dependent fmn reductase DUY81_04355 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DUY81_04360 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DUY81_04365 ENOG4108JQ6 ABC transporter DUY81_04370 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DUY81_04420 ENOG4105M4E phosphohistidine phosphatase, SixA DUY81_04425 ENOG4105I82 acetyl xylan esterase DUY81_04435 ENOG4105F0N pyrophosphate phospho-hydrolase DUY81_04445 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DUY81_04450 ENOG4108UGV hypoxanthine phosphoribosyltransferase DUY81_04460 ENOG4105EUJ GTP cyclohydrolase i DUY81_04465 ENOG4105EEI dihydropteroate synthase DUY81_04470 ENOG4105KRF dihydroneopterin aldolase DUY81_04490 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DUY81_04500 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DUY81_04560 ENOG4107ZXI Rhomboid family DUY81_04570 ENOG4105DP9 ABC transporter DUY81_04580 ENOG4108UCS ABC, transporter DUY81_04595 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DUY81_04600 ENOG4105D52 delta-aminolevulinic acid dehydratase DUY81_04610 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DUY81_04620 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DUY81_04625 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DUY81_04630 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DUY81_04645 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DUY81_04650 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DUY81_04660 ENOG4105EY0 Xylose isomerase domain protein TIM barrel DUY81_04695 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) DUY81_04700 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DUY81_04705 ENOG4108RH7 phosphoglycerate mutase DUY81_04710 ENOG4107ZT5 Thiol disulfide interchange protein DUY81_04715 ENOG4107QIV Cytochrome c biogenesis protein DUY81_04725 ENOG4105CRE cytochrome C DUY81_04745 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DUY81_04760 ENOG4105C7B Threonine dehydratase DUY81_04765 ENOG4105C01 Dihydroxy-acid dehydratase DUY81_04785 ENOG4105E0A ABC, transporter DUY81_04790 ENOG4108IHU transport system permease protein DUY81_04795 ENOG4105DQ5 transport system permease protein DUY81_04800 ENOG4108MES Periplasmic binding protein DUY81_04805 ENOG4105DSE periplasmic solute binding protein DUY81_04815 ENOG4105DIK (ABC) transporter DUY81_04820 ENOG4105CC5 ABC transporter DUY81_04835 ENOG4105CKI cobalamin synthesis protein DUY81_04845 ENOG4105W0E 50S ribosomal protein L33 DUY81_04850 ENOG4105NRA 50s ribosomal protein l31 type b DUY81_04855 ENOG4105YK5 50S ribosomal protein L36 DUY81_04860 ENOG41068HZ 50S ribosomal protein L32 DUY81_04865 ENOG4105KDC 50s ribosomal protein l28 DUY81_04870 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DUY81_04895 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DUY81_04900 ENOG4107NHD transcriptional regulator DUY81_04930 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DUY81_04935 ENOG4108SVG May play a role in the intracellular transport of hydrophobic ligands DUY81_04955 ENOG4105CI3 gtp-binding protein typa DUY81_04960 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DUY81_04975 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DUY81_04980 ENOG4105XTG Pfam:DUF156 DUY81_04995 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DUY81_05000 ENOG4105ZGE Toxic component of a toxin-antitoxin (TA) module. A DUY81_05005 ENOG4105VJK Transcription factor DUY81_05010 ENOG4105C12 Phosphoribosylglycinamide synthetase DUY81_05015 ENOG4105C83 adenylosuccinate lyase DUY81_05025 ENOG4108JU3 Alkyl hydroperoxide reductase DUY81_05030 ENOG4105D3R alkyl hydroperoxide reductase DUY81_05035 ENOG4105C8V SAICAR synthetase DUY81_05040 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I DUY81_05045 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DUY81_05060 ENOG4105HDK L-asparaginase DUY81_05075 ENOG4107QIK phosphoribosylformylglycinamidine synthase DUY81_05100 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DUY81_05115 ENOG4105CXB phosphoribosylaminoimidazole synthetase DUY81_05140 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DUY81_05145 ENOG4105C32 Amino acid ABC transporter (Permease) DUY81_05150 ENOG4105CF8 branched-chain amino acid ABC transporter, permease DUY81_05155 ENOG4105C0Z ABC transporter DUY81_05160 ENOG4108IV0 ABC, transporter DUY81_05260 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DUY81_05275 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DUY81_05330 ENOG4105DEN Luciferase family DUY81_05370 ENOG4105VDH Dihydroxyacetone kinase DUY81_05375 ENOG4108UTZ Dihydroxyacetone kinase DUY81_05380 ENOG4105CMT Dihydroxyacetone kinase DUY81_05400 ENOG4105BZ1 (ABC) transporter DUY81_05410 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DUY81_05415 ENOG4105CJ1 ABC, transporter DUY81_05440 ENOG4105E4F Isochorismate synthase DUY81_05445 ENOG4105P52 geranylgeranyl reductase DUY81_05455 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DUY81_05460 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DUY81_05465 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DUY81_05475 ENOG4107QIZ NADH dehydrogenase DUY81_05480 ENOG4108IEH NADH dehydrogenase subunit g DUY81_05485 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) DUY81_05490 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DUY81_05495 ENOG4105DF2 NADH dehydrogenase subunit j DUY81_05500 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DUY81_05515 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DUY81_05530 ENOG4105CPD ethanolamine ammonia-lyase DUY81_05535 ENOG4107FQ9 ethanolamine ammonia-lyase DUY81_05545 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DUY81_05550 ENOG4105C2J ABC transporter DUY81_05555 ENOG4107R9N ABC transporter DUY81_05560 ENOG41062B0 ABC transporter, permease DUY81_05570 ENOG4105C9K Endothelin-converting enzyme 1 DUY81_05575 ENOG4105DQU oxidoreductase, subunit beta DUY81_05580 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DUY81_05585 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DUY81_05590 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DUY81_05595 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DUY81_05635 ENOG4105WDJ 50S ribosomal protein L33 DUY81_05640 ENOG410900P UPF0336 protein DUY81_05650 ENOG4107R4N Cell wall formation (By similarity) DUY81_05655 ENOG4105XT2 Transcriptional regulator DUY81_05670 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DUY81_05675 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) DUY81_05680 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) DUY81_05685 ENOG4108VZM 50s ribosomal protein L10 DUY81_05690 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) DUY81_05695 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DUY81_05700 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DUY81_05715 ENOG4105EE0 oxidoreductase DUY81_05720 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DUY81_05725 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DUY81_05730 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DUY81_05735 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DUY81_05750 ENOG4105CX6 glutaminyL-tRNA synthetase DUY81_05755 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DUY81_05760 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) DUY81_05765 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DUY81_05770 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DUY81_05775 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) DUY81_05780 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DUY81_05785 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) DUY81_05790 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) DUY81_05795 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DUY81_05800 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DUY81_05805 ENOG41082SA 50s ribosomal protein l29 DUY81_05810 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DUY81_05820 ENOG4105ETE Transcriptional regulator (LacI family DUY81_05835 ENOG4105DRS transport system, permease DUY81_05840 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DUY81_05845 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) DUY81_05850 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) DUY81_05855 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DUY81_05860 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DUY81_05865 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DUY81_05870 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DUY81_05875 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DUY81_05880 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DUY81_05885 ENOG410849U 50S ribosomal protein L30 DUY81_05890 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DUY81_05925 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DUY81_05945 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) DUY81_05950 ENOG41067V7 50S ribosomal protein L36 DUY81_05960 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DUY81_05965 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DUY81_05970 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DUY81_05975 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DUY81_05980 ENOG4108ZT0 50S ribosomal protein l17 DUY81_05985 ENOG4108MJN Glycosyl Transferase DUY81_05995 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DUY81_06000 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DUY81_06010 ENOG4108JJB ABC transporter DUY81_06015 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DUY81_06025 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) DUY81_06030 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DUY81_06035 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DUY81_06045 ENOG4105C0R drug resistance transporter emrb qaca subfamily DUY81_06055 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DUY81_06060 ENOG4108UJD 30S ribosomal protein S9 DUY81_06065 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DUY81_06070 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DUY81_06080 ENOG4105CS9 pantothenic acid kinase DUY81_06085 ENOG4107QVI Methyltransferase, type 11 DUY81_06090 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DUY81_06095 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DUY81_06110 ENOG4105C1J atp-dependent rna helicase DUY81_06115 ENOG4108097 ATP-binding protein DUY81_06130 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DUY81_06150 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein DUY81_06170 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) DUY81_06175 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DUY81_06180 ENOG41072RD Membrane DUY81_06185 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DUY81_06195 ENOG4105EHE chorismate mutase- prephenate dehydrogenase DUY81_06200 ENOG4105D7W serine acetyltransferase DUY81_06205 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DUY81_06230 ENOG4105WH1 Two component transcriptional regulator luxr family DUY81_06235 ENOG4105Y3U Transglycosylase-associated protein DUY81_06245 ENOG4108UMI ABC transporter, permease DUY81_06250 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DUY81_06255 ENOG4105D01 (LipO)protein DUY81_06275 ENOG4105CMV Succinyl-CoA synthetase subunit beta DUY81_06305 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DUY81_06310 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) DUY81_06320 ENOG4105DC1 bifunctional purine biosynthesis protein purh DUY81_06330 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DUY81_06340 ENOG4108EKI Dehydrogenase DUY81_06345 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DUY81_06380 ENOG4107TFB basic membrane DUY81_06385 ENOG4108JQ9 ABC transporter DUY81_06390 ENOG4105UIB (ABC) transporter DUY81_06410 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DUY81_06420 ENOG4105CTU Proline racemase DUY81_06430 ENOG4107T4V d-proline reductase DUY81_06440 ENOG41088D5 d-proline reductase DUY81_06445 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) DUY81_06450 ENOG4105C8Y Acetylornithine aminotransferase DUY81_06465 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain DUY81_06485 ENOG4108JIK carboxylase DUY81_06495 ENOG4105DWF phosphomethylpyrimidine kinase DUY81_06510 ENOG4105CEU Arginine dihydrolase DUY81_06520 ENOG4107WR6 Maf-like protein DUY81_06530 ENOG4105D8K carboxyl transferase DUY81_06540 ENOG4105EC3 peptidase S51, dipeptidase E DUY81_06560 ENOG4108KGH TRANSCRIPTIONal DUY81_06575 ENOG4105CJT Mannose-1-phosphate guanylyltransferase DUY81_06585 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) DUY81_06625 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DUY81_06655 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) DUY81_06670 ENOG4105CE1 Ferrous iron transport protein b DUY81_06680 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DUY81_06685 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DUY81_06690 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DUY81_06695 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DUY81_06705 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DUY81_06730 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) DUY81_06735 ENOG41089BK Glutamine amido-transferase DUY81_06755 ENOG4105DFU Cell wall formation (By similarity) DUY81_06770 ENOG4105C0B DNA polymerase III (alpha subunit) DUY81_06780 ENOG4105CUB amino acid DUY81_06785 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DUY81_06805 ENOG4105CJ1 ABC, transporter DUY81_06830 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DUY81_06840 ENOG4108XG2 Histidine kinase DUY81_06845 ENOG4105WH1 Two component transcriptional regulator luxr family DUY81_06850 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DUY81_06860 ENOG4105C0D helicase DUY81_06890 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DUY81_06900 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) DUY81_06910 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) DUY81_06935 ENOG4105CQB FAD linked oxidase domain protein DUY81_06950 ENOG4108IQE Amp-dependent synthetase and ligase DUY81_06965 ENOG4105DXB Major Facilitator superfamily DUY81_06975 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DUY81_06990 ENOG4105MC2 DSBA oxidoreductase DUY81_06995 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DUY81_07010 ENOG4108YZG isomerase DUY81_07030 ENOG4105CRK lysyL-tRNA synthetase DUY81_07050 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DUY81_07055 ENOG4105DSF transport protein DUY81_07060 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DUY81_07065 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DUY81_07070 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DUY81_07080 ENOG4107RE3 peptidase, S41 DUY81_07095 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DUY81_07105 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) DUY81_07120 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DUY81_07125 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) DUY81_07140 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for DUY81_07145 ENOG4105ETE Transcriptional regulator (LacI family DUY81_07150 ENOG4105EG2 ABC transporter, permease DUY81_07155 ENOG4105D56 permease protein DUY81_07170 ENOG4105DIW FeS assembly protein SUFB DUY81_07185 ENOG4105C3K feS assembly ATPase SufC DUY81_07190 ENOG4105C9B Cysteine desulfurase DUY81_07195 ENOG4108UNV SUF system FeS assembly protein, NifU family DUY81_07225 ENOG4108UW5 maltose o-acetyltransferase DUY81_07240 ENOG4105C5H ABC transporter DUY81_07255 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DUY81_07270 ENOG4105CHR reductase DUY81_07285 ENOG4108IJ0 Aspartate ammonia-lyase DUY81_07295 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DUY81_07300 ENOG4105DKW ABC transporter DUY81_07315 ENOG4105DHU Bile acid DUY81_07340 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DUY81_07350 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DUY81_07365 ENOG4105DEG Vwa containing coxe family protein DUY81_07380 ENOG4108KDT Molybdate metabolism regulator DUY81_07385 ENOG4105CE9 30S ribosomal protein S2 DUY81_07390 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) DUY81_07395 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DUY81_07400 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DUY81_07405 ENOG4105KNE Phosphatidate cytidylyltransferase DUY81_07410 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DUY81_07415 ENOG4105D82 Glutamate dehydrogenase DUY81_07425 ENOG4105DZP Membrane-associated zinc metalloprotease DUY81_07430 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DUY81_07470 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DUY81_07490 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) DUY81_07495 ENOG4105CHV Transcription elongation factor NusA DUY81_07505 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DUY81_07510 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) DUY81_07515 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DUY81_07520 ENOG4108MDK Dehydrogenase DUY81_07530 ENOG4105VI0 Pts system, glucitol sorbitol-specific DUY81_07535 ENOG4105DZY Pts system, glucitol sorbitol-specific DUY81_07540 ENOG410787A Pts system, glucitol sorbitol-specific DUY81_07555 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DUY81_07575 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DUY81_07580 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DUY81_07585 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DUY81_07595 ENOG4105C7K acetolactate synthase DUY81_07605 ENOG4105CN5 Metallo-Beta-Lactamase DUY81_07610 ENOG4105VB9 50S ribosomal protein l28 DUY81_07630 ENOG4106H78 methyltransferase DUY81_07635 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DUY81_07645 ENOG41084BZ 50S ribosomal protein L32 DUY81_07650 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DUY81_07655 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DUY81_07700 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 DUY81_07735 ENOG4105K5M 30s ribosomal protein S16 DUY81_07740 ENOG41082KU UPF0109 protein DUY81_07745 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DUY81_07750 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DUY81_07765 ENOG4105E33 succinate dehydrogenase DUY81_07770 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DUY81_07775 ENOG4107QYR Signal peptidase i DUY81_07780 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DUY81_07790 ENOG41080R2 UPF0102 protein DUY81_07795 ENOG4105C0P Mg chelatase subunit ChlI DUY81_07825 ENOG4105DRS transport system, permease DUY81_07830 ENOG4105ETE Transcriptional regulator (LacI family DUY81_07840 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DUY81_07860 ENOG4107QNK )-transporter DUY81_07870 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) DUY81_07875 ENOG4105ETE Transcriptional regulator (LacI family DUY81_07885 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DUY81_07895 ENOG4105CPC Aldo Keto reductase DUY81_07910 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase DUY81_07915 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DUY81_07950 ENOG41090R7 Ferric uptake DUY81_07960 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DUY81_07970 ENOG4108IYU L-aspartate oxidase DUY81_07975 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DUY81_07985 ENOG4105CVK Glutamate decarboxylase DUY81_08000 ENOG4105E33 succinate dehydrogenase DUY81_08025 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein DUY81_08030 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DUY81_08035 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DUY81_08060 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase DUY81_08080 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DUY81_08090 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) DUY81_08100 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) DUY81_08110 ENOG4108QVN serine threonine protein kinase DUY81_08120 ENOG4105C0R drug resistance transporter emrb qaca subfamily DUY81_08150 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DUY81_08160 ENOG4107QVM von Willebrand factor, type A DUY81_08170 ENOG4105DFA alanine racemase domain protein DUY81_08185 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DUY81_08200 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DUY81_08215 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) DUY81_08225 ENOG4105CPC Aldo Keto reductase DUY81_08240 ENOG4105CD3 dihydroorotase DUY81_08245 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DUY81_08250 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DUY81_08255 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DUY81_08260 ENOG4107TYT Catalyzes the conversion of dihydroorotate to orotate (By similarity) DUY81_08265 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) DUY81_08270 ENOG4107T52 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DUY81_08300 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) DUY81_08310 ENOG4105CEV competence damage-inducible protein DUY81_08320 ENOG4105E98 transcriptional regulator DeoR family DUY81_08330 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DUY81_08335 ENOG4105KC9 Modulates RecA activity (By similarity) DUY81_08340 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) DUY81_08345 ENOG4107WI4 Aldose-1-epimerase DUY81_08350 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DUY81_08660 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DUY81_08665 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) DUY81_08670 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DUY81_08685 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) DUY81_08690 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DUY81_08695 ENOG4105DHP deoxycytidine triphosphate deaminase DUY81_08715 ENOG4105CQ7 ATP-dependent helicase DUY81_08725 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DUY81_08740 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DUY81_08760 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DUY81_08770 ENOG4105EPD Oligopeptide transporter, Opt family DUY81_08805 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DUY81_08825 ENOG4107VEG TrkA-N domain protein DUY81_08830 ENOG4105C0X amino acid DUY81_08835 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DUY81_08845 ENOG4107QM5 aconitate hydratase DUY81_08850 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DUY81_08865 ENOG4105E0X reductase DUY81_08870 ENOG4105CSR polyphosphate kinase 2 DUY81_08900 ENOG4108ZJ4 polysaccharide deacetylase DUY81_08925 ENOG4105DQ4 alcohol dehydrogenase DUY81_08930 ENOG4105C22 threonyL-tRNA synthetase DUY81_08945 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase DUY81_08950 ENOG4105E2K Glycosyl transferase (Group 1 DUY81_08975 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DUY81_08980 ENOG4108UW8 fha domain-containing protein DUY81_09005 ENOG4107RJF diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90) DUY81_09015 ENOG4107RTD sua5 ycio yrdc ywlc family protein DUY81_09020 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DUY81_09025 ENOG4107TE5 Lipid kinase DUY81_09030 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) DUY81_09035 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DUY81_09070 ENOG4107QZ7 Cellulose synthase catalytic subunit DUY81_09085 ENOG4105CUB amino acid DUY81_09100 ENOG4105D22 carbon starvation protein DUY81_09110 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DUY81_09115 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) DUY81_09125 ENOG4105Q70 DUY81_09130 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) DUY81_09135 ENOG4107R05 Transfers the fatty acyl group on membrane lipoproteins (By similarity) DUY81_09145 ENOG4105DWV Homoserine O-trans-acetylase DUY81_09150 ENOG4105DWV Homoserine O-trans-acetylase DUY81_09155 ENOG4105CYC Transferase DUY81_09175 ENOG4105DJ2 Major Facilitator Superfamily DUY81_09250 ENOG4105W1N transcriptional regulator DUY81_09265 ENOG4105DNP FAD linked oxidase domain protein DUY81_09275 ENOG4105C8Y Acetylornithine aminotransferase DUY81_09295 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DUY81_09305 ENOG4107S1Q Phosphatase DUY81_09405 ENOG4105DZR Type I site-specific deoxyribonuclease DUY81_09430 ENOG4108Z9K Osmotically inducible protein DUY81_09440 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DUY81_09445 ENOG4105CAT Cytidine monophosphate kinase DUY81_09455 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) DUY81_09460 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) DUY81_09475 ENOG4105C3R Methionine synthase DUY81_09485 ENOG4105DJV ribulose-phosphate 3-epimerase DUY81_09495 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DUY81_09530 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) DUY81_09535 ENOG4107QRT dEAD DEAH box helicase DUY81_09540 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DUY81_09550 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) DUY81_09555 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DUY81_09565 ENOG410803B Involved in the transcription termination process (By similarity) DUY81_09570 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DUY81_09580 ENOG4105D49 3-dehydroquinate synthase DUY81_09585 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DUY81_09590 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DUY81_09595 ENOG4105E2X shikimate dehydrogenase DUY81_09605 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DUY81_09610 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DUY81_09645 ENOG4105C9M aspartyl-trna synthetase DUY81_09660 ENOG4107MVR Transcriptional regulator DUY81_09665 ENOG4105CIZ coA-substrate-specific enzyme activase DUY81_09670 ENOG4105CUT histidyl-tRNA synthetase DUY81_09675 ENOG4105C5X domain protein DUY81_09680 ENOG4105C99 atpase involved in dna repair DUY81_09685 ENOG4105D98 threonine synthase DUY81_09690 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DUY81_09700 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DUY81_09705 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DUY81_09720 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DUY81_09725 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DUY81_09730 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) DUY81_09735 ENOG4105CDY transcriptional regulatory protein DUY81_09740 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DUY81_09745 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DUY81_09750 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DUY81_09755 ENOG4105CIH Imidazole acetol-phosphate transaminase DUY81_09760 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DUY81_09795 ENOG4105DRS transport system, permease DUY81_09805 ENOG4105ETE Transcriptional regulator (LacI family DUY81_09815 ENOG4105CBC glutamate synthase DUY81_09820 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) DUY81_09825 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) DUY81_09835 ENOG4105DK0 Indole-3-glycerol phosphate synthase DUY81_09850 ENOG4105CRQ synthase (Component I) DUY81_09855 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DUY81_09875 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DUY81_09880 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DUY81_09885 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DUY81_09910 ENOG4108IY8 ABC, transporter DUY81_09925 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DUY81_09945 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) DUY81_09950 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) DUY81_09955 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) DUY81_09970 ENOG4107UVD Beta-phosphoglucomutase family hydrolase DUY81_09980 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 DUY81_10005 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) DUY81_10035 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DUY81_10040 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DUY81_10045 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DUY81_10050 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DUY81_10055 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DUY81_10060 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) DUY81_10065 ENOG4106DE0 ATP synthase DUY81_10070 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) DUY81_10085 ENOG4105D7W serine acetyltransferase DUY81_10095 ENOG4105CAQ asparagine synthetase DUY81_10110 ENOG4105CEY Amp-dependent synthetase and ligase DUY81_10180 ENOG4105ESV Glycosyl transferase, family 4 DUY81_10190 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DUY81_10195 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DUY81_10200 ENOG4105VFB Binds the 23S rRNA (By similarity) DUY81_10210 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DUY81_10215 ENOG4105D6E homoserine dehydrogenase DUY81_10220 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DUY81_10230 ENOG4108URH decarboxylase DUY81_10240 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DUY81_10265 ENOG4105EMN RNA polymerase sigma factor DUY81_10275 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DUY81_10280 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DUY81_10290 ENOG4107TK4 histidinol-phosphate phosphatase DUY81_10295 ENOG4108JQ1 Dehydrogenase DUY81_10300 ENOG4108JQ6 ABC transporter DUY81_10310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DUY81_10320 ENOG4105DEF Extracellular solute-binding protein, family 5 DUY81_10340 ENOG4107QK4 glycoside hydrolase, family 3 domain protein DUY81_10350 ENOG4105DJZ UPF0182 protein DUY81_10360 ENOG41063PX domain protein DUY81_10385 ENOG4105DSY exodeoxyribonuclease V, gamma DUY81_10390 ENOG4107QKA exodeoxyribonuclease V beta DUY81_10395 ENOG4105C7H Helicase, RecD TraA family DUY81_10410 ENOG4105C4R Atp-dependent dna helicase DUY81_10415 ENOG4105VEQ Cold shock protein DUY81_10440 ENOG4105C31 Tryptophanyl-tRNA synthetase DUY81_10450 ENOG4105DB7 PHP domain protein DUY81_10470 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DUY81_10480 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea DUY81_10490 ENOG4105G3P Lipoprotein lpqB DUY81_10495 ENOG4105BZU Histidine kinase DUY81_10500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DUY81_10505 ENOG4108UJU UPF0301 protein DUY81_10520 ENOG4105CH7 arginosuccinase DUY81_10525 ENOG4105DBV ornithine carbamoyltransferase DUY81_10530 ENOG4105C8Y Acetylornithine aminotransferase DUY81_10535 ENOG4105CAS nag kinase DUY81_10540 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DUY81_10550 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DUY81_10555 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) DUY81_10560 ENOG4105CAK Cell division ATP-binding protein ftsE DUY81_10565 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) DUY81_10580 ENOG4105KAF membrAne DUY81_10595 ENOG4107QZI cell division protein FtsK DUY81_10610 ENOG4105CPF Cell wall formation (By similarity) DUY81_10620 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DUY81_10625 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DUY81_10630 ENOG41069M3 Transcriptional regulator DUY81_10650 ENOG4105ERH Fumarylacetoacetate hydrolase DUY81_10660 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DUY81_10665 ENOG4105CM2 brancheD-chain amino acid aminotransferase DUY81_10670 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DUY81_10690 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DUY81_10695 ENOG4108ZP8 Acetolactate synthase small subunit DUY81_10705 ENOG4105K59 histidine triad (HIT) protein DUY81_10710 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DUY81_10720 ENOG4107TE5 Lipid kinase DUY81_10730 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DUY81_10750 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) DUY81_10785 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DUY81_10790 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DUY81_10795 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DUY81_10810 ENOG4108JJB ABC transporter DUY81_10815 ENOG4105VKD bioY protein DUY81_10820 ENOG4105DSU hydrolase DUY81_10845 ENOG4105CPC Aldo Keto reductase DUY81_10860 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) DUY81_10865 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DUY81_10875 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DUY81_10885 ENOG4105DRP amino acid AbC transporter DUY81_10890 ENOG4105E5Q amino acid AbC transporter DUY81_10895 ENOG4105CT1 (ABC) transporter DUY81_10900 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DUY81_10910 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DUY81_10920 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DUY81_10940 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DUY81_10955 ENOG4108HGY Proline imino-peptidase DUY81_10980 ENOG4108IUX (ABC) transporter DUY81_10985 ENOG4105WH1 Two component transcriptional regulator luxr family DUY81_10995 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DUY81_11000 ENOG4107AQZ Membrane DUY81_11005 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DUY81_11010 ENOG4105C9U ATP-dependent DNA helicase RecQ DUY81_11020 ENOG4105CTS PTS system mannitol-specific DUY81_11025 ENOG4105CPQ Dehydrogenase DUY81_11035 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DUY81_11040 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) DUY81_11060 ENOG4105ECY inositol monophosphatase DUY81_11085 ENOG4105DRS transport system, permease DUY81_11095 ENOG4105CSH Transporter DUY81_11105 ENOG4105CIG ABC transporter DUY81_11115 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DUY81_11120 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DUY81_11130 ENOG4107SIQ Naphthoate synthase DUY81_11140 ENOG4105E4F Isochorismate synthase DUY81_11145 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DUY81_11150 ENOG4107TCW O-succinylbenzoate synthase DUY81_11170 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DUY81_11180 ENOG4107QW3 Sucrose phosphorylase DUY81_11185 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) DUY81_11195 ENOG4105F8X type iii restriction DUY81_11200 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DUY81_11210 ENOG4105C8T Leucyl-tRNA synthetase DUY81_11225 ENOG4107ZXU DSBA oxidoreductase DUY81_11230 ENOG4105E2A Dehydrogenase DUY81_11235 ENOG4107Y2X deaminase DUY81_11310 ENOG4105C5H ABC transporter DUY81_11345 ENOG4105F7P transcriptional regulator AsnC family DUY81_11410 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DUY81_11420 ENOG4108IG5 Transcriptional regulator DUY81_11510 ENOG41082EK Restriction modification system DNA (Specificity DUY81_11575 ENOG4105E4C Lytic transglycosylase catalytic DUY81_11705 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DUY81_11710 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) DUY81_11715 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DUY81_11720 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DUY81_11735 ENOG4105K46 50S ribosomal protein l27 DUY81_11740 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DUY81_11745 ENOG4105C03 ribonuclease DUY81_11755 ENOG4105D17 glycoside hydrolase, family 3 domain protein DUY81_11765 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DUY81_11775 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DUY81_11790 ENOG4105CP7 Triose-phosphate isomerase DUY81_11795 ENOG4105BZA Phosphoglycerate kinase DUY81_11800 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DUY81_11805 ENOG4105CIE May be required for sporulation (By similarity) DUY81_11810 ENOG4105CHW UPF0052 protein DUY81_11815 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DUY81_11820 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DUY81_11840 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DUY81_11855 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DUY81_11870 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DUY81_11875 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DUY81_11900 ENOG4105KA0 thioesterase Superfamily protein DUY81_11915 ENOG4105CA9 Pyruvate kinase DUY81_11930 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters DUY81_11945 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) DUY81_11950 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DUY81_11955 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DUY81_11960 ENOG4105ME9 cell division protein FtsQ DUY81_11965 ENOG4105DFU Cell wall formation (By similarity) DUY81_11970 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DUY81_11975 ENOG4105CNI cell division protein FtsW DUY81_11980 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DUY81_11985 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DUY81_12000 ENOG4105CJN penicillin-binding protein DUY81_12010 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DUY81_12015 ENOG4108V6E Cell division protein mraZ DUY81_12020 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DUY81_12030 ENOG4105F8C transglutaminase domain-containing protein DUY81_12040 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DUY81_12045 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DUY81_12050 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DUY81_12055 ENOG4105CJ1 ABC, transporter DUY81_12075 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family DUY81_12080 ENOG4105C6Z Gluconate DUY81_12085 ENOG4108J5G 6-phosphogluconate dehydrogenase DUY81_12095 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DUY81_12100 ENOG4105D7T ABC transporter DUY81_12120 ENOG4105C4R Atp-dependent dna helicase DUY81_12125 ENOG4105SYT Methylenetetrahydrofolate reductase DUY81_12135 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DUY81_12160 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase DUY81_12165 ENOG4105WH1 Two component transcriptional regulator luxr family DUY81_12185 ENOG4105DKQ ROK family DUY81_12230 ENOG4107S1N anthranilate phosphoribosyltransferase DUY81_12240 ENOG4105CCU oxidase (Subunit III) DUY81_12245 ENOG4107UDY cytochrome C DUY81_12250 ENOG4107EUI c reductase, iron-sulfur DUY81_12255 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DUY81_12270 ENOG4105MCD Part of cytochrome c oxidase, its function is DUY81_12275 ENOG4105BZ9 Cytochrome C oxidase, subunit I DUY81_12280 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) DUY81_12325 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) DUY81_12340 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DUY81_12350 ENOG4105C5H ABC transporter DUY81_12355 ENOG4105CJW magnesium transporter DUY81_12360 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN DUY81_12380 ENOG4105C5F glutamine synthetase DUY81_12390 ENOG4105VDM plasmid maintenance system antidote protein, xre family DUY81_12405 ENOG4105EGD dinuclear metal center protein, YbgI family DUY81_12415 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) DUY81_12440 ENOG4105D7N magnesium and cobalt transport protein CorA DUY81_12460 ENOG4105CUB amino acid DUY81_12465 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) DUY81_12480 ENOG4107T6F Xaa-Pro aminopeptidase DUY81_12515 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) DUY81_12520 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DUY81_12545 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DUY81_12550 ENOG4107QPH glycogen) synthase DUY81_12565 ENOG4108URH decarboxylase DUY81_12575 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) DUY81_12595 ENOG4108Z4U Ferredoxin DUY81_12600 ENOG4107RBI VanW family DUY81_12605 ENOG4107S1E Beta-lactamase DUY81_12610 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DUY81_12615 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DUY81_12620 ENOG4107Y80 Major Facilitator superfamily DUY81_12650 ENOG4105EF1 ribulokinase DUY81_12655 ENOG4105D49 3-dehydroquinate synthase DUY81_12665 ENOG4105D4U had-superfamily hydrolase, subfamily iia DUY81_12675 ENOG4107YVI ribose 5-phosphate isomerase DUY81_12680 ENOG4105E98 transcriptional regulator DeoR family DUY81_12685 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) DUY81_12690 ENOG4105CMT Dihydroxyacetone kinase DUY81_12695 ENOG4105CPQ Dehydrogenase DUY81_12700 ENOG4105C26 Dehydrogenase DUY81_12720 ENOG4105DIK (ABC) transporter DUY81_12725 ENOG4105CC5 ABC transporter DUY81_12755 ENOG4105E5Q amino acid AbC transporter DUY81_12760 ENOG4105CDA abc transporter atp-binding protein DUY81_12775 ENOG410848D S4 domain protein YaaA DUY81_12785 ENOG4105D5P Methylmalonyl-coA mutase DUY81_12790 ENOG4105CMN Methylmalonyl-coA mutase DUY81_12810 ENOG4108IQI permease DUY81_12830 ENOG4105RH4 Glycine cleavage system transcriptional repressor DUY81_12855 ENOG4105CSH Transporter DUY81_12860 ENOG4105CSH Transporter DUY81_12890 ENOG4108RWI nicotinamidase DUY81_12895 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DUY81_12915 ENOG4108ZM9 phosphoglycerate mutase DUY81_12920 ENOG4105BZ1 (ABC) transporter DUY81_12935 ENOG41065RQ ADP-ribosylation crystallin J1 DUY81_13025 ENOG4105C3G gtp-binding protein DUY81_13045 ENOG4105DFM M18 family aminopeptidase DUY81_13055 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DUY81_13060 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DUY81_13065 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DUY81_13075 ENOG4108IAB Phoh family DUY81_13085 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DUY81_13090 ENOG4105C7Z Conserved Protein DUY81_13105 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DUY81_13120 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DUY81_13125 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DUY81_13175 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DUY81_13180 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DUY81_13185 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DUY81_13195 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase DUY81_13200 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DUY81_13205 ENOG41084BS 50S ribosomal protein L35 DUY81_13210 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DUY81_13260 ENOG4105C0H protease DUY81_13265 ENOG4105EZR dyp-type peroxidase family protein DUY81_13295 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DUY81_13315 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DUY81_13320 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) DUY81_13325 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DUY81_13330 ENOG4107U1N Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DUY81_13340 ENOG4105U5Y Transcriptional regulator DUY81_13345 ENOG41082F9 transcriptional regulator DUY81_13350 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DUY81_13355 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DUY81_13360 ENOG4105F8V Hydrolase, tatD family DUY81_13375 ENOG4105C2W permease DUY81_13385 ENOG4105P4J Allophanate hydrolase, subunit 1 DUY81_13390 ENOG4105E7W lamb ycsf family protein DUY81_13445 ENOG4108Z0Z intracellular protease Pfpi family DUY81_13485 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein DUY81_13510 ENOG4105C0D helicase DUY81_13630 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DUY81_13645 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) DUY81_13670 ENOG4105C54 Major Facilitator superfamily DUY81_13675 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DUY81_13680 ENOG41060NJ transcriptional regulator DUY81_13690 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) DUY81_13695 ENOG4105DH8 myo-inositol catabolism DUY81_13705 ENOG4105D7K pfkb domain protein DUY81_13710 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DUY81_13720 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DUY81_13725 ENOG4107R5H iron (metal) dependent repressor, dtxr family DUY81_13730 ENOG4105CE4 GlcNAc 6-P deacetylase DUY81_13750 ENOG4105C7N Xanthine uracil vitamin C permease DUY81_13765 ENOG4105VEQ Cold shock protein DUY81_13770 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DUY81_13790 ENOG4106N3A copper homeostasis protein cutc DUY81_13805 ENOG4107T65 Integrase DUY81_14005 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DUY81_14125 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DUY81_14135 ENOG4105EIP mannose-6-phosphate isomerase DUY81_14140 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) DUY81_14165 ENOG4108YZT Adenosylcobinamide kinase DUY81_14170 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) DUY81_14180 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DUY81_14185 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DUY81_14190 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase DUY81_14195 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase DUY81_14200 ENOG4108JJB ABC transporter DUY81_14205 ENOG4108V4M Cobalt abc transporter DUY81_14215 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) DUY81_14230 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DUY81_14235 ENOG4105E4R Precorrin-3B C17-methyltransferase DUY81_14240 ENOG4105CIA precorrin-4 C(11)-methyltransferase DUY81_14250 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DUY81_14255 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) DUY81_14260 ENOG4105WH1 Two component transcriptional regulator luxr family DUY81_14265 ENOG4105BZU Histidine kinase DUY81_14285 ENOG4105CVJ phosphoglycerate mutase DUY81_14295 ENOG4108S01 response regulator DUY81_14300 ENOG4108ZGX Histidine kinase DUY81_14310 ENOG4108M15 ABC transporter DUY81_14315 ENOG4108UVJ appr-1-p processing domain protein DUY81_14325 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DUY81_14330 ENOG4105CPQ Dehydrogenase DUY81_14335 ENOG4105DRS transport system, permease DUY81_14350 ENOG4105DKQ ROK family DUY81_14355 ENOG4105EJQ L-serine dehydratase DUY81_14365 ENOG4107URF beta-phospho-glucomutase DUY81_14390 ENOG4105F5W AtP-binding protein DUY81_14445 ENOG4105C28 cystathionine DUY81_14460 ENOG4105C8N cysteinyl-tRNA synthetase DUY81_14475 ENOG4105EQ0 Major Facilitator superfamily DUY81_14480 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DUY81_14500 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DUY81_14505 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DUY81_14520 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DUY81_14530 ENOG4105DT3 PTS system, galactitol-specific IIc component DUY81_14540 ENOG41082GB PTS system galactitol-specific transporter subunit IIA DUY81_14545 ENOG4108VJ1 Transcriptional regulator (CarD family DUY81_14560 ENOG4105BZU Histidine kinase DUY81_14565 ENOG4108UTW Plays a role in the regulation of phosphate uptake DUY81_14570 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DUY81_14575 ENOG410849S phosphocarrier protein (HPr) DUY81_14580 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DUY81_14590 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein DUY81_14595 ENOG4107QX3 carboxylase DUY81_14600 ENOG4107QX3 carboxylase DUY81_14605 ENOG4107QSA Oxaloacetate decarboxylase DUY81_14610 ENOG4107RCW fructose-bisphosphate aldolase DUY81_14625 ENOG4105DQR SNARE associated Golgi DUY81_14645 ENOG4107YJ4 chain length determinant protein DUY81_14680 ENOG4105E2K Glycosyl transferase (Group 1 DUY81_14700 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) DUY81_14705 ENOG4108V0P LemA family DUY81_14725 ENOG4105CHM Aminotransferase DUY81_14730 ENOG4105C26 Dehydrogenase DUY81_14740 ENOG4105E90 ABC transporter DUY81_14745 ENOG4108IJ8 ABC transporter DUY81_14750 ENOG4105E90 ABC transporter DUY81_14770 ENOG4108HQS Glycine betaine DUY81_14775 ENOG4108IJ7 Glycine betaine DUY81_14805 ENOG4105CVR type I restriction-modification system DUY81_14815 ENOG4105DZR Type I site-specific deoxyribonuclease DUY81_14820 ENOG4105ETE Transcriptional regulator (LacI family DUY81_14825 ENOG4107FKK extracellular solute-binding protein family 1 DUY81_14830 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DUY81_14835 ENOG4105DRS transport system, permease DUY81_14850 ENOG4105ECR NmrA family DUY81_14865 ENOG4105ECB domain protein DUY81_14880 ENOG4105F8D glycoside hydrolase family 4 DUY81_14885 ENOG4105E98 transcriptional regulator DeoR family DUY81_14890 ENOG4105EDK PfkB domain protein DUY81_14900 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DUY81_14905 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DUY81_14910 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DUY81_14920 ENOG4105DRS transport system, permease DUY81_14935 ENOG4107RBJ symporter DUY81_14945 ENOG4105ETE Transcriptional regulator (LacI family DUY81_14950 ENOG4105WYW fructose-bisphosphate aldolase DUY81_14965 ENOG4105BZU Histidine kinase DUY81_14970 ENOG4105WH1 Two component transcriptional regulator luxr family DUY81_14980 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DUY81_14985 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DUY81_14995 ENOG4105C85 amino acid DUY81_15000 ENOG4107WGA YidE YbjL DUY81_15005 ENOG4107FQX Alpha-acetolactate decarboxylase DUY81_15010 ENOG4105CPQ Dehydrogenase DUY81_15015 ENOG4105KNI merR family transcriptional Regulator DUY81_15020 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DUY81_15025 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DUY81_15030 ENOG4105CFG Acts as a chaperone (By similarity) DUY81_15045 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DUY81_15050 ENOG4105BZU Histidine kinase DUY81_15055 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DUY81_15070 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DUY81_15075 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) DUY81_15080 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) DUY81_15085 ENOG4105EAC phosphoserine phosphatase DUY81_15090 ENOG4105DSB aldose 1-epimerase DUY81_15105 ENOG4105EJ2 Transcriptional regulator DUY81_15110 ENOG4105CJ1 ABC, transporter DUY81_15125 ENOG4107QNK )-transporter DUY81_15130 ENOG4108JQ7 (ABC) transporter DUY81_15180 ENOG4108IJ0 Aspartate ammonia-lyase DUY81_15185 ENOG4108JQ6 ABC transporter DUY81_15190 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DUY81_15195 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DUY81_15220 ENOG4105ETE Transcriptional regulator (LacI family DUY81_15225 ENOG4105ETE Transcriptional regulator (LacI family DUY81_15265 ENOG4105ETE Transcriptional regulator (LacI family DUY81_15270 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) DUY81_15280 ENOG4105C9F isomerase DUY81_15285 ENOG4105DET Rhamnulokinase DUY81_15290 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) DUY81_15295 ENOG4105C26 Dehydrogenase DUY81_15305 ENOG4105C54 Major Facilitator superfamily DUY81_15325 ENOG4105C75 arginyL-tRNA synthetase DUY81_15330 ENOG4105CV8 reductase DUY81_15335 ENOG4105IE8 Alpha-ketoglutarate permease DUY81_15350 ENOG4107QP8 phosphohexose isomerase DUY81_15360 ENOG4105CQR helicase DUY81_15370 ENOG4108V1U phospholipid-binding protein DUY81_15390 ENOG4108FN7 Aldo keto reductase DUY81_15400 ENOG41083TI Protein CrcB homolog DUY81_15405 ENOG41085J0 Protein CrcB homolog DUY81_15425 ENOG4107RSM transcriptional regulator DUY81_15430 ENOG4105D94 Major Facilitator Superfamily DUY81_15450 ENOG4105CFH Aspartokinase DUY81_15470 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DUY81_15475 ENOG4108HCJ Hydrolase DUY81_15480 ENOG410667J hydrolase DUY81_15495 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DUY81_15520 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DUY81_15525 ENOG41087ID Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DUY81_15570 ENOG4105CIG ABC transporter DUY81_15575 ENOG4108X07 Tetr family transcriptional regulator DUY81_15580 ENOG4105C85 amino acid DUY81_15600 ENOG4105CSH Transporter DUY81_15655 ENOG4105F5W AtP-binding protein DUY81_15675 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) DUY81_15685 ENOG4107WAU Protein tyrosine phosphatase DUY81_15690 ENOG4107YJ4 chain length determinant protein DUY81_15695 ENOG4105D3Q Sugar transferase DUY81_15700 ENOG4108KGH TRANSCRIPTIONal DUY81_15715 ENOG4105D3Q Sugar transferase DUY81_15720 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DUY81_15735 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DUY81_15740 ENOG4105C1B dTDP-glucose 4-6-dehydratase DUY81_15750 ENOG4105TV9 FHA Domain-Containing protein DUY81_15755 ENOG4105HZM Fha domain containing protein DUY81_15770 ENOG4105CJN penicillin-binding protein DUY81_15790 ENOG4105ZJT Cell division protein CrgA DUY81_15795 ENOG4105CRK lysyL-tRNA synthetase DUY81_15800 ENOG4105K8R UPF0145 protein DUY81_15810 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease DUY81_15815 ENOG4105CK2 sodium dicarboxylate symporter DUY81_15825 ENOG4105C5R Aminotransferase DUY81_15850 ENOG4107R1Q Membrane protein FdrA DUY81_15855 ENOG4107REC cytoplasmic protein DUY81_15865 ENOG4105C5B carbamate kinase DUY81_15880 ENOG4107VXZ Hydrolase DUY81_15885 ENOG4105KBX Transcriptional regulator, TetR family DUY81_15900 ENOG4105ETE Transcriptional regulator (LacI family DUY81_15910 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DUY81_15915 ENOG4105XN3 extracellular solute-binding protein family 1 DUY81_15925 ENOG4108JB8 alcohol dehydrogenase DUY81_15960 ENOG4105C4M (Ubiquinol oxidase) subunit I DUY81_15965 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DUY81_15970 ENOG4108JJ9 ABC, transporter DUY81_15975 ENOG4105BZ1 (ABC) transporter DUY81_15985 ENOG41080R8 Conserved Protein DUY81_15995 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DUY81_16000 ENOG4105DAA L-lactate DUY81_16005 ENOG41073TP transcriptional regulator DUY81_16025 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) DUY81_16035 ENOG4105F0R Cytidylyltransferase DUY81_16040 ENOG4105D2T synthase DUY81_16070 ENOG4105CG5 Glycosyl transferase (Group 1 DUY81_16095 ENOG4107YJ4 chain length determinant protein DUY81_16145 ENOG4105K6T rare lipoprotein A DUY81_16160 ENOG4105VPX protein, conserved in bacteria DUY81_16165 ENOG4105CDU Replicative dna helicase DUY81_16170 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) DUY81_16175 ENOG4105K63 Thioredoxin DUY81_16180 ENOG4105C3M thioredoxin reductase DUY81_16185 ENOG4108V06 Glutathione peroxidase DUY81_16190 ENOG4108V8F Transcriptional regulator, MarR family DUY81_16210 ENOG4108VX5 3-methyladenine DNA glycosylase DUY81_16225 ENOG4105CQ7 ATP-dependent helicase DUY81_16240 ENOG4105KHC sulfurtransferase DUY81_16275 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DUY81_16280 ENOG4107QPH glycogen) synthase DUY81_16290 ENOG4108IJ1 Dehydrogenase DUY81_16295 ENOG4105CDA abc transporter atp-binding protein DUY81_16300 ENOG4107UBR Extracellular solute-binding protein family 3 DUY81_16305 ENOG4108Q1T ABC transporter DUY81_16310 ENOG4105DRP amino acid AbC transporter DUY81_16315 ENOG4105E98 transcriptional regulator DeoR family DUY81_16320 ENOG4105DE4 1-phosphofructokinase DUY81_16325 ENOG4105DM4 PTS System DUY81_16355 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DUY81_16390 ENOG4107T8Q Glycosyl transferase (Group 1 DUY81_16395 ENOG4107T8Q Glycosyl transferase (Group 1 DUY81_16480 ENOG4105F95 Monooxygenase DUY81_16495 ENOG4108Z7F N-acetyltransferase DUY81_16505 ENOG4105C37 (CBS) domain DUY81_16535 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DUY81_16550 ENOG4105CPQ Dehydrogenase DUY81_16555 ENOG4107T5V SNARE associated Golgi DUY81_16565 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DUY81_16575 ENOG4105DKW ABC transporter DUY81_16595 ENOG4105D1H recombination factor protein RarA DUY81_16600 ENOG4105ETE Transcriptional regulator (LacI family DUY81_16615 ENOG41073TP transcriptional regulator DUY81_16620 ENOG4105EQN UPF0261 protein DUY81_16655 ENOG4105CT4 transporter