locus-tag	class	description
DUY81_00075	COG1904	glucuronate isomerase
DUY81_00080	COG2721	sulfolactate sulfo-lyase activity
DUY81_00090	COG1609	Transcriptional regulator
DUY81_00095	COG1414	Transcriptional regulator
DUY81_00100	COG0800	Aldolase
DUY81_00105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DUY81_00110	COG1482	cell wall glycoprotein biosynthetic process
DUY81_00120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DUY81_00170	COG0395	ABC-type sugar transport system, permease component
DUY81_00175	COG1653	transport
DUY81_00180	COG0584	glycerophosphoryl diester phosphodiesterase
DUY81_00185	COG1609	Transcriptional regulator
DUY81_00195	COG1285	pathogenesis
DUY81_00215	COG4948	Mandelate Racemase Muconate Lactonizing
DUY81_00225	COG0656	L-ascorbic acid biosynthetic process
DUY81_00235	COG1312	Catalyzes the dehydration of D-mannonate
DUY81_00240	COG0246	Mannitol dehydrogenase
DUY81_00245	COG1904	glucuronate isomerase
DUY81_00250	COG1609	Transcriptional regulator
DUY81_00260	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_00300	COG1129	ABC transporter
DUY81_00320	COG3386	PFAM SMP-30 Gluconolaconase
DUY81_00325	COG0352	thiamine-phosphate diphosphorylase activity
DUY81_00330	COG0351	phosphomethylpyrimidine kinase
DUY81_00330	COG0352	thiamine-phosphate diphosphorylase activity
DUY81_00330	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DUY81_00335	COG2364	Membrane
DUY81_00340	COG0315	cyclic pyranopterin monophosphate synthase activity
DUY81_00340	COG0521	Mo-molybdopterin cofactor biosynthetic process
DUY81_00345	COG0315	cyclic pyranopterin monophosphate synthase activity
DUY81_00355	COG0314	molybdopterin synthase activity
DUY81_00365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DUY81_00385	COG1140	nitrate reductase beta subunit
DUY81_00410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DUY81_00415	COG0633	Ferredoxin
DUY81_00415	COG0543	2 iron, 2 sulfur cluster binding
DUY81_00420	COG1151	hydroxylamine reductase activity
DUY81_00430	COG2337	Toxic component of a toxin-antitoxin (TA) module
DUY81_00460	COG0601	transmembrane transport
DUY81_00475	COG4166	transmembrane transport
DUY81_00485	COG0456	acetyltransferase
DUY81_00510	COG1484	DNA-dependent DNA replication
DUY81_00550	COG1484	DNA-dependent DNA replication
DUY81_00600	COG0783	Belongs to the Dps family
DUY81_00605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DUY81_00615	COG2217	Heavy metal translocating P-type atpase
DUY81_00625	COG3189	MarR family transcriptional regulator
DUY81_00665	COG0205	6-phosphofructokinase activity
DUY81_00690	COG0577	efflux transmembrane transporter activity
DUY81_00690	COG1136	(ABC) transporter
DUY81_00700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DUY81_00710	COG0511	ligase activity, forming carbon-carbon bonds
DUY81_00720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DUY81_00725	COG0045	succinate-CoA ligase (ADP-forming) activity
DUY81_00725	COG1042	CoA-binding domain protein
DUY81_00725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DUY81_00730	COG1254	Belongs to the acylphosphatase family
DUY81_00750	COG0281	malic enzyme
DUY81_00765	COG1321	iron dependent repressor
DUY81_00765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DUY81_00770	COG1914	H( )-stimulated, divalent metal cation uptake system
DUY81_00775	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DUY81_00780	COG0477	Major facilitator Superfamily
DUY81_00790	COG2814	Major facilitator Superfamily
DUY81_00800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DUY81_00805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DUY81_00815	COG0438	transferase activity, transferring glycosyl groups
DUY81_00825	COG2409	Drug exporters of the RND superfamily
DUY81_00830	COG1309	transcriptional regulator
DUY81_00850	COG2022	thiamine diphosphate biosynthetic process
DUY81_00865	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DUY81_00900	COG0656	L-ascorbic acid biosynthetic process
DUY81_00925	COG0730	response to heat
DUY81_00940	COG0175	sulfate reduction
DUY81_00965	COG2132	Multicopper oxidase
DUY81_00975	COG0745	RESPONSE REGULATOR receiver
DUY81_00980	COG5002	protein histidine kinase activity
DUY81_00990	COG4585	Histidine kinase
DUY81_00995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DUY81_01000	COG2205	protein histidine kinase activity
DUY81_01035	COG1132	(ABC) transporter
DUY81_01040	COG0477	Major facilitator Superfamily
DUY81_01045	COG1690	Belongs to the RtcB family
DUY81_01050	COG3657	addiction module killer protein
DUY81_01055	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DUY81_01070	COG2197	response regulator
DUY81_01075	COG1136	(ABC) transporter
DUY81_01100	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DUY81_01125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DUY81_01135	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_01200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DUY81_01220	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DUY81_01230	COG1175	transmembrane transport
DUY81_01245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DUY81_01250	COG1126	abc transporter atp-binding protein
DUY81_01255	COG0765	amino acid transport
DUY81_01260	COG0148	phosphopyruvate hydratase activity
DUY81_01265	COG0095	Lipoate-protein ligase
DUY81_01275	COG1131	(ABC) transporter
DUY81_01290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DUY81_01295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DUY81_01305	COG3775	system Galactitol-specific IIC component
DUY81_01310	COG3414	Phosphotransferase system galactitol-specific IIB component
DUY81_01315	COG1063	alcohol dehydrogenase
DUY81_01325	COG0235	Class ii aldolase
DUY81_01350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DUY81_01355	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_01365	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DUY81_01370	COG0039	L-malate dehydrogenase activity
DUY81_01375	COG0281	malic enzyme
DUY81_01390	COG0039	L-malate dehydrogenase activity
DUY81_01435	COG1396	sequence-specific DNA binding
DUY81_01440	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
DUY81_01450	COG1028	Short-chain dehydrogenase reductase Sdr
DUY81_01475	COG1869	D-ribose catabolic process
DUY81_01480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DUY81_01485	COG1879	ABC-type sugar transport system periplasmic component
DUY81_01490	COG1172	Belongs to the binding-protein-dependent transport system permease family
DUY81_01495	COG1129	ABC transporter
DUY81_01500	COG1609	Transcriptional regulator
DUY81_01510	COG3266	domain, Protein
DUY81_01515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DUY81_01520	COG0187	DNA topoisomerase II activity
DUY81_01530	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DUY81_01535	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DUY81_01545	COG0592	DNA-directed DNA polymerase activity
DUY81_01550	COG1136	(ABC) transporter
DUY81_01550	COG0577	efflux transmembrane transporter activity
DUY81_01555	COG1136	(ABC) transporter
DUY81_01555	COG0577	efflux transmembrane transporter activity
DUY81_01560	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DUY81_01570	COG0594	ribonuclease P activity
DUY81_01580	COG0706	membrane insertase activity
DUY81_01590	COG2076	Multidrug Resistance protein
DUY81_01595	COG0357	Ribosomal RNA small subunit methyltransferase G
DUY81_01605	COG1192	Involved in chromosome partitioning
DUY81_01615	COG1793	dna ligase
DUY81_01615	COG3285	dna ligase
DUY81_01630	COG1181	Belongs to the D-alanine--D-alanine ligase family
DUY81_01635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DUY81_01655	COG1082	Xylose isomerase domain protein TIM barrel
DUY81_01660	COG0673	inositol 2-dehydrogenase activity
DUY81_01665	COG1082	Xylose isomerase domain protein TIM barrel
DUY81_01675	COG2814	Major facilitator Superfamily
DUY81_01685	COG2814	Major facilitator Superfamily
DUY81_01690	COG0673	inositol 2-dehydrogenase activity
DUY81_01700	COG0673	inositol 2-dehydrogenase activity
DUY81_01705	COG1082	Xylose isomerase domain protein TIM barrel
DUY81_01710	COG2855	membrane
DUY81_01720	COG1609	Transcriptional regulator
DUY81_01725	COG0673	inositol 2-dehydrogenase activity
DUY81_01730	COG1082	Xylose isomerase domain protein TIM barrel
DUY81_01740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DUY81_01755	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DUY81_01755	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DUY81_01770	COG1660	Displays ATPase and GTPase activities
DUY81_01785	COG0626	cystathionine gamma-synthase activity
DUY81_01795	COG2124	cytochrome p450
DUY81_01810	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DUY81_01865	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DUY81_01890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DUY81_01940	COG0564	pseudouridine synthase activity
DUY81_01950	COG1733	regulation of RNA biosynthetic process
DUY81_01960	COG1609	Transcriptional regulator
DUY81_01980	COG0395	ABC-type sugar transport system, permease component
DUY81_01995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DUY81_02005	COG2390	Transcriptional regulator
DUY81_02010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DUY81_02015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DUY81_02025	COG1595	DNA-templated transcription, initiation
DUY81_02030	COG2815	serine threonine protein kinase
DUY81_02030	COG0515	serine threonine protein kinase
DUY81_02050	COG0385	Bile acid
DUY81_02055	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_02070	COG1929	Belongs to the glycerate kinase type-1 family
DUY81_02080	COG0668	transmembrane transport
DUY81_02095	COG0540	Belongs to the ATCase OTCase family
DUY81_02100	COG1349	DNA-binding transcription factor activity
DUY81_02105	COG2814	Major facilitator Superfamily
DUY81_02140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DUY81_02145	COG0114	fumarate hydratase activity
DUY81_02155	COG3830	Belongs to the UPF0237 family
DUY81_02160	COG2848	UPF0210 protein
DUY81_02170	COG0038	chloride channel
DUY81_02210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DUY81_02220	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DUY81_02265	COG2267	carboxylic ester hydrolase activity
DUY81_02270	COG0686	Belongs to the AlaDH PNT family
DUY81_02275	COG0205	6-phosphofructokinase activity
DUY81_02285	COG0515	serine threonine protein kinase
DUY81_02290	COG0842	Transport permease protein
DUY81_02290	COG1131	(ABC) transporter
DUY81_02290	COG1716	ATPase activity
DUY81_02295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DUY81_02300	COG2146	nitrite reductase [NAD(P)H] activity
DUY81_02310	COG3609	addiction module antidote protein, CC2985 family
DUY81_02315	COG2337	Toxic component of a toxin-antitoxin (TA) module
DUY81_02350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DUY81_02375	COG1175	transmembrane transport
DUY81_02385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DUY81_02395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DUY81_02510	COG1113	amino acid transport
DUY81_02520	COG1846	Transcriptional regulator
DUY81_02525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DUY81_02530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DUY81_02535	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
DUY81_02540	COG0247	lactate metabolic process
DUY81_02545	COG4585	Histidine kinase
DUY81_02550	COG0277	FAD linked oxidase domain protein
DUY81_02595	COG0300	oxidoreductase activity
DUY81_02610	COG1022	Amp-dependent synthetase and ligase
DUY81_02620	COG0672	)-iron permease
DUY81_02630	COG2837	iron assimilation
DUY81_02635	COG0360	Binds together with S18 to 16S ribosomal RNA
DUY81_02645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DUY81_02650	COG0359	binds to the 23S rRNA
DUY81_02660	COG1968	undecaprenyl-diphosphatase activity
DUY81_02695	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DUY81_02705	COG2205	protein histidine kinase activity
DUY81_02720	COG1609	Transcriptional regulator
DUY81_02730	COG1175	transmembrane transport
DUY81_02735	COG0395	ABC-type sugar transport system, permease component
DUY81_02755	COG2423	ornithine cyclodeaminase activity
DUY81_02770	COG1132	(ABC) transporter
DUY81_02790	COG0366	Alpha amylase catalytic
DUY81_02795	COG0395	ABC-type sugar transport system, permease component
DUY81_02810	COG1940	carbohydrate kinase activity
DUY81_02830	COG1285	pathogenesis
DUY81_02835	COG1175	transmembrane transport
DUY81_02840	COG0395	ABC-type sugar transport system, permease component
DUY81_02845	COG1653	transport
DUY81_02880	COG0366	Alpha amylase catalytic
DUY81_02890	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DUY81_02945	COG0477	Major facilitator Superfamily
DUY81_02950	COG1621	beta-fructofuranosidase activity
DUY81_02965	COG5002	protein histidine kinase activity
DUY81_02975	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DUY81_02975	COG3976	FMN-binding domain protein
DUY81_03000	COG1715	Restriction endonuclease
DUY81_03045	COG0765	amino acid transport
DUY81_03050	COG0765	amino acid transport
DUY81_03055	COG1126	abc transporter atp-binding protein
DUY81_03075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DUY81_03080	COG0154	amidase activity
DUY81_03120	COG0006	proline dipeptidase activity
DUY81_03125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DUY81_03135	COG0477	Major facilitator Superfamily
DUY81_03160	COG1233	COG1233 Phytoene dehydrogenase and related
DUY81_03170	COG0022	dehydrogenase e1 component
DUY81_03175	COG0508	dehydrogenase complex catalyzes the overall conversion of
DUY81_03185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DUY81_03195	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DUY81_03215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DUY81_03235	COG3833	ABC-type maltose transport systems, permease component
DUY81_03250	COG1609	Transcriptional regulator
DUY81_03255	COG0561	phosphatase activity
DUY81_03275	COG0137	argininosuccinate synthase activity
DUY81_03280	COG3321	synthase
DUY81_03280	COG1028	Short-chain dehydrogenase reductase Sdr
DUY81_03280	COG0604	alcohol dehydrogenase
DUY81_03305	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DUY81_03310	COG1609	Transcriptional regulator
DUY81_03315	COG1316	TRANSCRIPTIONal
DUY81_03340	COG0584	glycerophosphoryl diester phosphodiesterase
DUY81_03345	COG0823	Involved in the tonB-independent uptake of proteins
DUY81_03345	COG4946	Tricorn protease homolog
DUY81_03345	COG1506	peptidase
DUY81_03350	COG2130	NADP-dependent
DUY81_03375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DUY81_03420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DUY81_03430	COG1174	glycine betaine transport
DUY81_03440	COG0517	IMP dehydrogenase activity
DUY81_03440	COG1125	glycine betaine transport
DUY81_03445	COG3263	regulation of cellular component size
DUY81_03460	COG0433	COG0433 Predicted ATPase
DUY81_03480	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DUY81_03490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DUY81_03510	COG1942	4-Oxalocrotonate Tautomerase
DUY81_03515	COG0673	inositol 2-dehydrogenase activity
DUY81_03525	COG1946	Acyl-CoA thioesterase
DUY81_03530	COG2376	Dihydroxyacetone kinase
DUY81_03535	COG1063	alcohol dehydrogenase
DUY81_03540	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DUY81_03550	COG1064	alcohol dehydrogenase
DUY81_03560	COG0390	transport system, permease component
DUY81_03570	COG1968	undecaprenyl-diphosphatase activity
DUY81_03575	COG0745	RESPONSE REGULATOR receiver
DUY81_03585	COG0438	transferase activity, transferring glycosyl groups
DUY81_03595	COG0586	Pfam SNARE associated Golgi protein
DUY81_03610	COG0183	Belongs to the thiolase family
DUY81_03620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DUY81_03630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DUY81_03645	COG0402	S-adenosylhomocysteine deaminase activity
DUY81_03680	COG0395	ABC-type sugar transport system, permease component
DUY81_03685	COG1175	transmembrane transport
DUY81_03690	COG1653	transport
DUY81_03715	COG1609	Transcriptional regulator
DUY81_03740	COG1518	maintenance of DNA repeat elements
DUY81_03740	COG1468	defense response to virus
DUY81_03790	COG3158	transport of potassium into the cell
DUY81_03810	COG4572	Cation transport regulator
DUY81_03830	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DUY81_03855	COG1295	ribonuclease BN
DUY81_03870	COG1028	Short-chain dehydrogenase reductase Sdr
DUY81_03875	COG0783	Belongs to the Dps family
DUY81_03885	COG1028	Short-chain dehydrogenase reductase Sdr
DUY81_03890	COG2124	cytochrome p450
DUY81_03895	COG3285	dna ligase
DUY81_03895	COG1793	dna ligase
DUY81_03920	COG2197	response regulator
DUY81_03930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DUY81_03930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DUY81_03965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DUY81_03970	COG0534	Mate efflux family protein
DUY81_03980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DUY81_04000	COG1072	(Pantothenic acid kinase))
DUY81_04005	COG1069	ribulokinase activity
DUY81_04020	COG3022	response to hydroperoxide
DUY81_04035	COG4608	Belongs to the ABC transporter superfamily
DUY81_04040	COG0444	Belongs to the ABC transporter superfamily
DUY81_04045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DUY81_04050	COG0601	transmembrane transport
DUY81_04080	COG1846	Transcriptional regulator
DUY81_04085	COG2040	homocysteine
DUY81_04110	COG1408	metallophosphoesterase
DUY81_04115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DUY81_04150	COG0494	nUDIX hydrolase
DUY81_04240	COG1205	dead DEAH box helicase
DUY81_04240	COG1111	helicase
DUY81_04245	COG2890	protein-(glutamine-N5) methyltransferase activity
DUY81_04255	COG1754	DNA topoisomerase type I activity
DUY81_04255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DUY81_04265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DUY81_04270	COG0470	DNA polymerase III
DUY81_04280	COG1774	PSP1 C-terminal conserved region
DUY81_04320	COG1231	oxidoreductase activity
DUY81_04325	COG0431	NADPH-dependent FMN reductase
DUY81_04355	COG0601	transmembrane transport
DUY81_04360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DUY81_04365	COG4172	Belongs to the ABC transporter superfamily
DUY81_04370	COG1619	proteins homologs of microcin C7 resistance protein MccF
DUY81_04375	COG1522	sequence-specific DNA binding
DUY81_04420	COG2062	phosphohistidine phosphatase, SixA
DUY81_04425	COG3458	cephalosporin-C deacetylase activity
DUY81_04435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DUY81_04445	COG0037	tRNA processing
DUY81_04460	COG0302	gtp cyclohydrolase
DUY81_04465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DUY81_04470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DUY81_04475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DUY81_04490	COG0649	NAD binding
DUY81_04500	COG0542	response to heat
DUY81_04560	COG0457	Tetratricopeptide repeat
DUY81_04560	COG0705	Rhomboid family
DUY81_04570	COG4143	(ABC) transporter
DUY81_04580	COG3842	ATPase activity
DUY81_04595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DUY81_04600	COG0113	porphobilinogen synthase activity
DUY81_04610	COG0181	hydroxymethylbilane synthase activity
DUY81_04620	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DUY81_04625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DUY81_04640	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DUY81_04645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DUY81_04660	COG1082	Xylose isomerase domain protein TIM barrel
DUY81_04665	COG0506	proline dehydrogenase activity
DUY81_04695	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DUY81_04700	COG1648	precorrin-2 dehydrogenase activity
DUY81_04700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DUY81_04705	COG0406	alpha-ribazole phosphatase activity
DUY81_04710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DUY81_04715	COG0785	Cytochrome C biogenesis protein
DUY81_04725	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DUY81_04745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DUY81_04760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DUY81_04765	COG0129	dihydroxy-acid dehydratase activity
DUY81_04785	COG1120	ATPase activity
DUY81_04790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DUY81_04795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DUY81_04800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DUY81_04805	COG0803	Belongs to the bacterial solute-binding protein 9 family
DUY81_04815	COG1121	(ABC) transporter
DUY81_04820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DUY81_04835	COG0523	cobalamin synthesis protein
DUY81_04845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DUY81_04850	COG0254	rRNA binding
DUY81_04855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DUY81_04865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DUY81_04870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DUY81_04895	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DUY81_04900	COG0745	RESPONSE REGULATOR receiver
DUY81_04930	COG1490	D-aminoacyl-tRNA deacylase activity
DUY81_04935	COG3485	protocatechuate 3,4-dioxygenase
DUY81_04945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DUY81_04960	COG2337	Toxic component of a toxin-antitoxin (TA) module
DUY81_04975	COG0446	pyridine nucleotide-disulphide oxidoreductase
DUY81_04980	COG1937	Protein conserved in bacteria
DUY81_04995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DUY81_05000	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
DUY81_05005	COG4423	Transcription factor
DUY81_05010	COG0151	Belongs to the GarS family
DUY81_05015	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DUY81_05025	COG3634	alkyl hydroperoxide reductase activity
DUY81_05030	COG0450	alkyl hydroperoxide reductase
DUY81_05035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DUY81_05040	COG0047	phosphoribosylformylglycinamidine synthase activity
DUY81_05045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DUY81_05055	COG1113	amino acid transport
DUY81_05060	COG0252	asparaginase activity
DUY81_05075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DUY81_05115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DUY81_05140	COG0395	ABC-type sugar transport system, permease component
DUY81_05260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DUY81_05275	COG3848	Pyruvate phosphate dikinase
DUY81_05275	COG0574	Belongs to the PEP-utilizing enzyme family
DUY81_05320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DUY81_05330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DUY81_05350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DUY81_05370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DUY81_05370	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DUY81_05370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DUY81_05375	COG1461	Dihydroxyacetone kinase
DUY81_05380	COG2376	Dihydroxyacetone kinase
DUY81_05400	COG1132	(ABC) transporter
DUY81_05410	COG2226	methyltransferase
DUY81_05415	COG1131	(ABC) transporter
DUY81_05445	COG0644	oxidoreductase
DUY81_05455	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DUY81_05460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DUY81_05465	COG0649	NAD binding
DUY81_05475	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DUY81_05480	COG1034	ATP synthesis coupled electron transport
DUY81_05485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DUY81_05490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DUY81_05500	COG0713	ATP synthesis coupled electron transport
DUY81_05515	COG1007	ATP synthesis coupled electron transport
DUY81_05570	COG3590	peptidase
DUY81_05575	COG1013	pyruvate-flavodoxin oxidoreductase activity
DUY81_05580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DUY81_05580	COG0674	pyruvate-flavodoxin oxidoreductase activity
DUY81_05585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DUY81_05590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DUY81_05590	COG0649	NAD binding
DUY81_05595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DUY81_05635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DUY81_05640	COG2030	dehydratase
DUY81_05650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DUY81_05655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DUY81_05670	COG0250	Participates in transcription elongation, termination and antitermination
DUY81_05675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DUY81_05680	COG0081	regulation of translation
DUY81_05685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DUY81_05690	COG0222	ribosome binding
DUY81_05695	COG0085	RNA polymerase activity
DUY81_05700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DUY81_05715	COG0673	inositol 2-dehydrogenase activity
DUY81_05720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DUY81_05725	COG0049	tRNA binding
DUY81_05730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DUY81_05735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DUY81_05750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DUY81_05755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DUY81_05760	COG0051	transcription antitermination factor activity, RNA binding
DUY81_05765	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DUY81_05770	COG0088	Forms part of the polypeptide exit tunnel
DUY81_05775	COG0089	rRNA binding
DUY81_05780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DUY81_05785	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DUY81_05790	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DUY81_05795	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DUY81_05800	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DUY81_05805	COG0255	Belongs to the universal ribosomal protein uL29 family
DUY81_05810	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DUY81_05830	COG1175	transmembrane transport
DUY81_05835	COG0395	ABC-type sugar transport system, permease component
DUY81_05840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DUY81_05845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DUY81_05850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DUY81_05855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DUY81_05860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DUY81_05865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DUY81_05870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DUY81_05875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DUY81_05880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DUY81_05885	COG1841	ribosomal large subunit assembly
DUY81_05890	COG0200	Binds to the 23S rRNA
DUY81_05925	COG0563	adenylate kinase activity
DUY81_05945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DUY81_05950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DUY81_05960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DUY81_05965	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DUY81_05970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DUY81_05975	COG0202	RNA polymerase activity
DUY81_05980	COG0203	ribosomal protein L17
DUY81_05985	COG0438	transferase activity, transferring glycosyl groups
DUY81_05995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DUY81_05995	COG0519	Catalyzes the synthesis of GMP from XMP
DUY81_06010	COG3845	ABC transporter
DUY81_06015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DUY81_06030	COG0101	tRNA pseudouridine synthase activity
DUY81_06035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DUY81_06055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DUY81_06060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DUY81_06070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DUY81_06080	COG1072	(Pantothenic acid kinase))
DUY81_06090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DUY81_06095	COG0736	holo-[acyl-carrier-protein] synthase activity
DUY81_06110	COG0513	Belongs to the DEAD box helicase family
DUY81_06115	COG0802	atpase or kinase
DUY81_06120	COG0456	acetyltransferase
DUY81_06120	COG1214	PFAM Peptidase M22, glycoprotease
DUY81_06130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DUY81_06150	COG1355	regulation of microtubule-based process
DUY81_06170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DUY81_06175	COG0459	protein refolding
DUY81_06195	COG0287	Prephenate dehydrogenase
DUY81_06195	COG1605	Chorismate mutase
DUY81_06200	COG1045	serine acetyltransferase
DUY81_06205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DUY81_06205	COG0519	Catalyzes the synthesis of GMP from XMP
DUY81_06230	COG2197	response regulator
DUY81_06235	COG2261	transglycosylase associated protein
DUY81_06245	COG2011	ABC-type metal ion transport system permease component
DUY81_06250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DUY81_06255	COG1464	Belongs to the NlpA lipoprotein family
DUY81_06275	COG0045	succinate-CoA ligase (ADP-forming) activity
DUY81_06305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DUY81_06305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DUY81_06310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DUY81_06320	COG0138	bifunctional purine biosynthesis protein purh
DUY81_06330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DUY81_06345	COG0039	L-malate dehydrogenase activity
DUY81_06365	COG1253	flavin adenine dinucleotide binding
DUY81_06410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DUY81_06430	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DUY81_06440	COG5275	peptidyl-tyrosine sulfation
DUY81_06440	COG0252	asparaginase activity
DUY81_06445	COG4656	Part of a membrane complex involved in electron transport
DUY81_06450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DUY81_06465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DUY81_06485	COG4770	biotin carboxylase activity
DUY81_06495	COG0351	phosphomethylpyrimidine kinase
DUY81_06505	COG4221	oxidoreductase activity
DUY81_06520	COG0424	maF-like protein
DUY81_06530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DUY81_06540	COG3340	Belongs to the peptidase S51 family
DUY81_06560	COG1316	TRANSCRIPTIONal
DUY81_06575	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DUY81_06575	COG0662	Cupin 2, conserved barrel domain protein
DUY81_06625	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DUY81_06655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DUY81_06670	COG1918	ferrous iron import across plasma membrane
DUY81_06670	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DUY81_06680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DUY81_06685	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DUY81_06690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DUY81_06695	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DUY81_06705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DUY81_06730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DUY81_06755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DUY81_06770	COG0587	DNA-directed DNA polymerase activity
DUY81_06780	COG0531	amino acid
DUY81_06785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DUY81_06805	COG1131	(ABC) transporter
DUY81_06820	COG1113	amino acid transport
DUY81_06830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DUY81_06840	COG4585	Histidine kinase
DUY81_06845	COG2197	response regulator
DUY81_06850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DUY81_06860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DUY81_06885	COG1794	racemase activity, acting on amino acids and derivatives
DUY81_06890	COG0519	Catalyzes the synthesis of GMP from XMP
DUY81_06900	COG4106	trans-aconitate 2-methyltransferase activity
DUY81_06910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DUY81_06935	COG0247	lactate metabolic process
DUY81_06935	COG0277	FAD linked oxidase domain protein
DUY81_06950	COG1022	Amp-dependent synthetase and ligase
DUY81_06965	COG2814	Major facilitator Superfamily
DUY81_06975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DUY81_06990	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DUY81_06995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DUY81_07010	COG0698	ribose 5-phosphate isomerase
DUY81_07030	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DUY81_07030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DUY81_07050	COG0544	peptidyl-prolyl cis-trans isomerase activity
DUY81_07060	COG0740	serine-type endopeptidase activity
DUY81_07065	COG0740	serine-type endopeptidase activity
DUY81_07070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DUY81_07080	COG4946	Tricorn protease homolog
DUY81_07080	COG0793	Belongs to the peptidase S41A family
DUY81_07095	COG0525	valine-tRNA ligase activity
DUY81_07105	COG0363	glucosamine-6-phosphate deaminase activity
DUY81_07120	COG0109	protoheme IX farnesyltransferase activity
DUY81_07125	COG1612	heme a metabolic process
DUY81_07135	COG1131	(ABC) transporter
DUY81_07140	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DUY81_07145	COG1609	Transcriptional regulator
DUY81_07150	COG3833	ABC-type maltose transport systems, permease component
DUY81_07155	COG1175	transmembrane transport
DUY81_07170	COG0719	Fe-S assembly protein
DUY81_07185	COG0396	ATPase activity
DUY81_07190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DUY81_07225	COG0110	maltose O-acetyltransferase activity
DUY81_07240	COG0488	(ABC) transporter
DUY81_07270	COG1028	Short-chain dehydrogenase reductase Sdr
DUY81_07295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DUY81_07300	COG1119	ATPase activity
DUY81_07340	COG0242	peptide deformylase activity
DUY81_07350	COG4974	Belongs to the 'phage' integrase family
DUY81_07365	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DUY81_07380	COG3831	ATPase activity
DUY81_07385	COG0052	Belongs to the universal ribosomal protein uS2 family
DUY81_07390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DUY81_07395	COG0528	UMP kinase activity
DUY81_07400	COG0233	cytoplasmic translational termination
DUY81_07405	COG0575	Belongs to the CDS family
DUY81_07410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DUY81_07415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DUY81_07425	COG0750	zinc metalloprotease
DUY81_07430	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DUY81_07460	COG1305	Transglutaminase-like
DUY81_07470	COG0442	prolyl-tRNA aminoacylation
DUY81_07490	COG0779	Required for maturation of 30S ribosomal subunits
DUY81_07495	COG0195	Participates in both transcription termination and antitermination
DUY81_07505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DUY81_07515	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DUY81_07520	COG0371	Dehydrogenase
DUY81_07535	COG3732	PTS system glucitol sorbitol-specific
DUY81_07555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DUY81_07575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DUY81_07580	COG1185	polyribonucleotide nucleotidyltransferase activity
DUY81_07585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DUY81_07595	COG0028	Belongs to the TPP enzyme family
DUY81_07605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DUY81_07610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DUY81_07630	COG0742	ribosomal rna small subunit methyltransferase
DUY81_07635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DUY81_07645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DUY81_07650	COG0571	ribonuclease III activity
DUY81_07655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DUY81_07660	COG0656	L-ascorbic acid biosynthetic process
DUY81_07735	COG0228	four-way junction DNA binding
DUY81_07740	COG1837	Belongs to the UPF0109 family
DUY81_07745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DUY81_07750	COG0336	Belongs to the RNA methyltransferase TrmD family
DUY81_07760	COG1053	succinate dehydrogenase
DUY81_07765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DUY81_07770	COG0335	large ribosomal subunit rRNA binding
DUY81_07775	COG0681	Belongs to the peptidase S26 family
DUY81_07780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DUY81_07790	COG0792	nuclease activity
DUY81_07795	COG0606	chelatase, subunit chli
DUY81_07820	COG1175	transmembrane transport
DUY81_07825	COG0395	ABC-type sugar transport system, permease component
DUY81_07830	COG1609	Transcriptional regulator
DUY81_07840	COG0395	ABC-type sugar transport system, permease component
DUY81_07870	COG2160	L-arabinose isomerase activity
DUY81_07875	COG1609	Transcriptional regulator
DUY81_07885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DUY81_07895	COG0667	Aldo Keto reductase
DUY81_07905	COG3201	nicotinamide mononucleotide transporter
DUY81_07910	COG0140	phosphoribosyl-ATP diphosphatase activity
DUY81_07915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DUY81_07950	COG0735	belongs to the Fur family
DUY81_07960	COG0423	glycine-tRNA ligase activity
DUY81_07970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DUY81_07975	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DUY81_07985	COG0076	glutamate decarboxylase activity
DUY81_07995	COG1053	succinate dehydrogenase
DUY81_08000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DUY81_08025	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DUY81_08030	COG0358	DNA primase activity
DUY81_08035	COG1191	sigma factor activity
DUY81_08060	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DUY81_08080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DUY81_08090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DUY81_08100	COG0583	DNA-binding transcription factor activity
DUY81_08110	COG0515	serine threonine protein kinase
DUY81_08120	COG0477	Major facilitator Superfamily
DUY81_08150	COG0714	Associated with various cellular activities
DUY81_08160	COG2304	oxidoreductase activity
DUY81_08185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DUY81_08190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DUY81_08200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DUY81_08215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DUY81_08225	COG0667	Aldo Keto reductase
DUY81_08240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DUY81_08245	COG0505	Belongs to the CarA family
DUY81_08250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DUY81_08255	COG0543	2 iron, 2 sulfur cluster binding
DUY81_08260	COG0167	dihydroorotate dehydrogenase activity
DUY81_08265	COG0284	orotidine-5'-phosphate decarboxylase activity
DUY81_08270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DUY81_08300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DUY81_08310	COG1058	Belongs to the CinA family
DUY81_08310	COG1546	Belongs to the CinA family
DUY81_08320	COG1349	DNA-binding transcription factor activity
DUY81_08335	COG2137	regulation of response to DNA damage stimulus
DUY81_08340	COG1418	mRNA catabolic process
DUY81_08345	COG2017	converts alpha-aldose to the beta-anomer
DUY81_08350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DUY81_08660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DUY81_08665	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DUY81_08670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DUY81_08685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DUY81_08690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DUY81_08695	COG0717	Belongs to the dCTP deaminase family
DUY81_08715	COG1643	Atp-dependent helicase
DUY81_08725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DUY81_08740	COG0187	DNA topoisomerase II activity
DUY81_08760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DUY81_08770	COG1297	OPT oligopeptide transporter protein
DUY81_08805	COG0756	dUTP diphosphatase activity
DUY81_08825	COG0569	domain protein
DUY81_08830	COG0531	amino acid
DUY81_08835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DUY81_08845	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DUY81_08850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DUY81_08865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DUY81_08870	COG2326	polyphosphate kinase activity
DUY81_08900	COG0726	polysaccharide deacetylase
DUY81_08925	COG1064	alcohol dehydrogenase
DUY81_08930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DUY81_08945	COG1560	Kdo2-lipid A biosynthetic process
DUY81_08950	COG0438	transferase activity, transferring glycosyl groups
DUY81_08980	COG1716	ATPase activity
DUY81_09005	COG0205	6-phosphofructokinase activity
DUY81_09015	COG0009	L-threonylcarbamoyladenylate synthase
DUY81_09020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DUY81_09025	COG1597	lipid kinase activity
DUY81_09030	COG1472	Belongs to the glycosyl hydrolase 3 family
DUY81_09035	COG1739	Uncharacterized protein family UPF0029
DUY81_09085	COG0531	amino acid
DUY81_09100	COG1966	Carbon starvation protein
DUY81_09110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DUY81_09115	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DUY81_09130	COG1216	Glycosyl transferase, family 2
DUY81_09135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DUY81_09140	COG1522	sequence-specific DNA binding
DUY81_09145	COG2813	Specifically methylates the guanine in position
DUY81_09145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DUY81_09150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DUY81_09155	COG0427	acetyl-CoA hydrolase
DUY81_09175	COG2807	transmembrane transport
DUY81_09205	COG3550	peptidyl-serine autophosphorylation
DUY81_09250	COG3226	Transcriptional regulator
DUY81_09265	COG0277	FAD linked oxidase domain protein
DUY81_09275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DUY81_09295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DUY81_09305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DUY81_09405	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DUY81_09430	COG1764	response to oxidative stress
DUY81_09440	COG1160	GTP binding
DUY81_09445	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DUY81_09455	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DUY81_09460	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DUY81_09475	COG0646	methionine synthase
DUY81_09475	COG1410	methionine synthase
DUY81_09485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DUY81_09495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DUY81_09530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DUY81_09535	COG1201	RNA secondary structure unwinding
DUY81_09540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DUY81_09550	COG1758	RNA polymerase activity
DUY81_09555	COG0194	GDP metabolic process
DUY81_09565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DUY81_09570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DUY81_09580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DUY81_09585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DUY81_09590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DUY81_09595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DUY81_09600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DUY81_09605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DUY81_09610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DUY81_09645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DUY81_09660	COG1309	transcriptional regulator
DUY81_09670	COG0124	histidyl-tRNA synthetase
DUY81_09675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DUY81_09680	COG1196	nuclear chromosome segregation
DUY81_09685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DUY81_09690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DUY81_09700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DUY81_09705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DUY81_09710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DUY81_09720	COG2255	four-way junction helicase activity
DUY81_09725	COG0632	four-way junction helicase activity
DUY81_09730	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DUY81_09735	COG0217	transcriptional regulatory protein
DUY81_09740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DUY81_09745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DUY81_09750	COG0131	Imidazoleglycerol-phosphate dehydratase
DUY81_09755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DUY81_09760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DUY81_09795	COG0395	ABC-type sugar transport system, permease component
DUY81_09815	COG0067	glutamate synthase
DUY81_09815	COG0070	glutamate synthase
DUY81_09815	COG0069	glutamate synthase activity
DUY81_09820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DUY81_09825	COG0159	tryptophan synthase activity
DUY81_09835	COG0134	indole-3-glycerol-phosphate synthase activity
DUY81_09850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DUY81_09855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DUY81_09870	COG2233	PERMEase
DUY81_09875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DUY81_09880	COG0154	amidase activity
DUY81_09885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DUY81_09900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DUY81_09910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DUY81_09925	COG0482	sulfurtransferase activity
DUY81_09945	COG0366	Alpha amylase catalytic
DUY81_09950	COG3281	Trehalose synthase
DUY81_09955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DUY81_09970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DUY81_09980	COG0033	Phosphoglucomutase
DUY81_10035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DUY81_10040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DUY81_10045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DUY81_10050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DUY81_10055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DUY81_10060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DUY81_10065	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DUY81_10070	COG0356	it plays a direct role in the translocation of protons across the membrane
DUY81_10085	COG1045	serine acetyltransferase
DUY81_10095	COG0367	asparagine synthase
DUY81_10100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DUY81_10110	COG0318	PFAM AMP-dependent synthetase and ligase
DUY81_10180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DUY81_10190	COG2890	protein-(glutamine-N5) methyltransferase activity
DUY81_10195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DUY81_10200	COG0254	rRNA binding
DUY81_10210	COG0083	homoserine kinase activity
DUY81_10215	COG0460	homoserine dehydrogenase
DUY81_10220	COG0019	diaminopimelate decarboxylase activity
DUY81_10230	COG1611	Belongs to the LOG family
DUY81_10240	COG0508	dehydrogenase complex catalyzes the overall conversion of
DUY81_10240	COG0567	Dehydrogenase, E1 component
DUY81_10265	COG1595	DNA-templated transcription, initiation
DUY81_10275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DUY81_10280	COG1162	GTPase activity
DUY81_10290	COG0483	inositol monophosphate 1-phosphatase activity
DUY81_10295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DUY81_10320	COG0747	negative chemotaxis
DUY81_10350	COG1615	UPF0182 protein
DUY81_10360	COG3480	Lon protease (S16) C-terminal proteolytic domain
DUY81_10385	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DUY81_10390	COG1074	ATP-dependent DNA helicase activity
DUY81_10395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DUY81_10410	COG0210	DNA helicase
DUY81_10415	COG1278	Cold shock
DUY81_10440	COG0180	Tryptophanyl-tRNA synthetase
DUY81_10450	COG0613	PHP domain protein
DUY81_10470	COG0653	protein targeting
DUY81_10480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DUY81_10490	COG5401	PFAM Sporulation and spore germination
DUY81_10495	COG5002	protein histidine kinase activity
DUY81_10500	COG0745	RESPONSE REGULATOR receiver
DUY81_10505	COG1678	Uncharacterized ACR, COG1678
DUY81_10520	COG0165	Argininosuccinate lyase
DUY81_10525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DUY81_10535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DUY81_10545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DUY81_10550	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DUY81_10555	COG2177	Part of the ABC transporter FtsEX involved in
DUY81_10560	COG2884	Cell division ATP-binding protein ftsE
DUY81_10565	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DUY81_10580	COG3152	Membrane
DUY81_10595	COG1674	ftsk spoiiie
DUY81_10610	COG1181	Belongs to the D-alanine--D-alanine ligase family
DUY81_10620	COG0066	3-isopropylmalate dehydratase activity
DUY81_10625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DUY81_10630	COG1414	Transcriptional regulator
DUY81_10650	COG0179	Fumarylacetoacetate (FAA) hydrolase
DUY81_10660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DUY81_10665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DUY81_10670	COG0473	3-isopropylmalate dehydrogenase activity
DUY81_10690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DUY81_10695	COG0440	acetolactate synthase activity
DUY81_10705	COG0537	adenosine 5'-monophosphoramidase activity
DUY81_10710	COG0107	imidazoleglycerol-phosphate synthase activity
DUY81_10730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DUY81_10750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DUY81_10785	COG0504	CTP synthase activity
DUY81_10790	COG0497	DNA recombination
DUY81_10795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DUY81_10810	COG1122	ATPase activity
DUY81_10815	COG1268	BioY protein
DUY81_10820	COG0647	UMP catabolic process
DUY81_10845	COG0667	Aldo Keto reductase
DUY81_10850	COG4716	Myosin-crossreactive antigen
DUY81_10860	COG1381	Involved in DNA repair and RecF pathway recombination
DUY81_10865	COG1404	Belongs to the peptidase S8 family
DUY81_10875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DUY81_10885	COG0765	amino acid transport
DUY81_10890	COG0765	amino acid transport
DUY81_10895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DUY81_10900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DUY81_10910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DUY81_10920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DUY81_10940	COG2226	methyltransferase
DUY81_10955	COG0596	Alpha beta hydrolase
DUY81_10980	COG4152	abc transporter atp-binding protein
DUY81_10985	COG2197	response regulator
DUY81_10995	COG0343	queuine tRNA-ribosyltransferase activity
DUY81_11000	COG5006	permease, DMT superfamily
DUY81_11005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DUY81_11020	COG2213	PTS system mannitol-specific
DUY81_11020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DUY81_11025	COG1063	alcohol dehydrogenase
DUY81_11035	COG0484	heat shock protein binding
DUY81_11040	COG1420	regulation of RNA biosynthetic process
DUY81_11060	COG0483	inositol monophosphate 1-phosphatase activity
DUY81_11080	COG1175	transmembrane transport
DUY81_11085	COG0395	ABC-type sugar transport system, permease component
DUY81_11095	COG0477	Major facilitator Superfamily
DUY81_11100	COG1309	transcriptional regulator
DUY81_11105	COG1131	(ABC) transporter
DUY81_11115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DUY81_11120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DUY81_11130	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DUY81_11140	COG1169	isochorismate synthase
DUY81_11145	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DUY81_11150	COG4948	Mandelate Racemase Muconate Lactonizing
DUY81_11170	COG0481	GTPase activity
DUY81_11185	COG0268	Binds directly to 16S ribosomal RNA
DUY81_11195	COG1061	Type III restriction enzyme res subunit
DUY81_11200	COG2333	competence protein COMEC
DUY81_11200	COG0658	competence protein
DUY81_11210	COG0495	leucyl-tRNA aminoacylation
DUY81_11225	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DUY81_11230	COG1063	alcohol dehydrogenase
DUY81_11235	COG0590	tRNA wobble adenosine to inosine editing
DUY81_11310	COG0488	(ABC) transporter
DUY81_11345	COG1522	sequence-specific DNA binding
DUY81_11350	COG1280	lysine exporter protein (LysE YggA)
DUY81_11405	COG2801	Transposase and inactivated derivatives
DUY81_11410	COG2130	NADP-dependent
DUY81_11420	COG1309	transcriptional regulator
DUY81_11485	COG4974	Belongs to the 'phage' integrase family
DUY81_11510	COG0732	type I restriction modification DNA specificity domain
DUY81_11575	COG0739	heme binding
DUY81_11575	COG0741	lytic transglycosylase activity
DUY81_11575	COG1196	nuclear chromosome segregation
DUY81_11705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DUY81_11710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DUY81_11715	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DUY81_11720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DUY81_11735	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DUY81_11740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DUY81_11745	COG1530	ribonuclease E activity
DUY81_11755	COG1472	Belongs to the glycosyl hydrolase 3 family
DUY81_11765	COG0105	UTP biosynthetic process
DUY81_11775	COG0285	dihydrofolate synthase activity
DUY81_11785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DUY81_11790	COG0149	triose-phosphate isomerase activity
DUY81_11795	COG0126	phosphoglycerate kinase activity
DUY81_11800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DUY81_11805	COG1481	regulation of sporulation
DUY81_11810	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DUY81_11815	COG1660	Displays ATPase and GTPase activities
DUY81_11820	COG0322	excinuclease ABC activity
DUY81_11840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DUY81_11855	COG0556	nucleotide-excision repair
DUY81_11870	COG0237	dephospho-CoA kinase activity
DUY81_11875	COG0539	negative regulation of cytoplasmic translation
DUY81_11900	COG2050	protein possibly involved in aromatic compounds catabolism
DUY81_11915	COG0469	pyruvate kinase activity
DUY81_11930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DUY81_11945	COG1799	cell septum assembly
DUY81_11955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DUY81_11965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DUY81_11970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DUY81_11975	COG0772	Belongs to the SEDS family
DUY81_11980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DUY81_11985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DUY81_11990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DUY81_12000	COG0768	penicillin binding
DUY81_12010	COG0275	rRNA processing
DUY81_12015	COG2001	Belongs to the MraZ family
DUY81_12020	COG0714	Associated with various cellular activities
DUY81_12040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DUY81_12045	COG0509	glycine decarboxylation via glycine cleavage system
DUY81_12050	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DUY81_12050	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DUY81_12055	COG1131	(ABC) transporter
DUY81_12075	COG3265	gluconokinase activity
DUY81_12085	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DUY81_12095	COG0596	Alpha beta hydrolase
DUY81_12100	COG1116	anion transmembrane transporter activity
DUY81_12100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DUY81_12120	COG0210	DNA helicase
DUY81_12125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DUY81_12135	COG0352	thiamine-phosphate diphosphorylase activity
DUY81_12145	COG2815	serine threonine protein kinase
DUY81_12145	COG0515	serine threonine protein kinase
DUY81_12160	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DUY81_12165	COG2197	response regulator
DUY81_12185	COG1940	carbohydrate kinase activity
DUY81_12230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DUY81_12240	COG1845	cytochrome c oxidase, subunit III
DUY81_12245	COG2010	Cytochrome c
DUY81_12250	COG0723	plastoquinol--plastocyanin reductase activity
DUY81_12255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DUY81_12275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DUY81_12280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DUY81_12320	COG0508	dehydrogenase complex catalyzes the overall conversion of
DUY81_12325	COG0321	lipoyl(octanoyl) transferase activity
DUY81_12340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DUY81_12350	COG0488	(ABC) transporter
DUY81_12355	COG2239	Acts as a magnesium transporter
DUY81_12360	COG0586	Pfam SNARE associated Golgi protein
DUY81_12380	COG0174	glutamine synthetase
DUY81_12390	COG3093	addiction module antidote protein HigA
DUY81_12405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DUY81_12415	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DUY81_12440	COG0598	Magnesium transport protein CorA
DUY81_12460	COG0531	amino acid
DUY81_12465	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DUY81_12480	COG0006	proline dipeptidase activity
DUY81_12515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DUY81_12520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DUY81_12545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DUY81_12550	COG0297	glycogen (starch) synthase activity
DUY81_12565	COG1611	Belongs to the LOG family
DUY81_12575	COG2171	N-acyltransferase activity
DUY81_12600	COG2720	vancomycin resistance protein
DUY81_12605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DUY81_12610	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DUY81_12615	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DUY81_12620	COG2814	Major facilitator Superfamily
DUY81_12655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DUY81_12665	COG0647	UMP catabolic process
DUY81_12675	COG0698	ribose 5-phosphate isomerase
DUY81_12680	COG1349	DNA-binding transcription factor activity
DUY81_12685	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DUY81_12690	COG2376	Dihydroxyacetone kinase
DUY81_12695	COG1063	alcohol dehydrogenase
DUY81_12700	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_12720	COG1121	(ABC) transporter
DUY81_12725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DUY81_12755	COG0765	amino acid transport
DUY81_12760	COG1126	abc transporter atp-binding protein
DUY81_12775	COG2501	S4 domain
DUY81_12810	COG0833	amino acid
DUY81_12825	COG2133	pyrroloquinoline quinone binding
DUY81_12830	COG2716	regulation of RNA biosynthetic process
DUY81_12855	COG0477	Major facilitator Superfamily
DUY81_12860	COG0477	Major facilitator Superfamily
DUY81_12865	COG1028	Short-chain dehydrogenase reductase Sdr
DUY81_12865	COG3321	synthase
DUY81_12865	COG0604	alcohol dehydrogenase
DUY81_12890	COG1335	isochorismatase
DUY81_12895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DUY81_12915	COG0406	alpha-ribazole phosphatase activity
DUY81_12920	COG1132	(ABC) transporter
DUY81_12935	COG1397	ADP-ribosylglycohydrolase
DUY81_13025	COG0012	GTP binding
DUY81_13045	COG1362	aminopeptidase activity
DUY81_13050	COG1322	Protein conserved in bacteria
DUY81_13055	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DUY81_13060	COG1570	exodeoxyribonuclease VII activity
DUY81_13065	COG1722	exodeoxyribonuclease VII activity
DUY81_13075	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DUY81_13085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DUY81_13090	COG1331	Highly conserved protein containing a thioredoxin domain
DUY81_13105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DUY81_13120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DUY81_13125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DUY81_13175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DUY81_13180	COG0072	phenylalanine-tRNA ligase activity
DUY81_13180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DUY81_13185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DUY81_13195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DUY81_13200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DUY81_13205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DUY81_13210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DUY81_13260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DUY81_13265	COG2837	iron assimilation
DUY81_13295	COG0148	phosphopyruvate hydratase activity
DUY81_13315	COG0193	aminoacyl-tRNA hydrolase activity
DUY81_13320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DUY81_13325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DUY81_13330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DUY81_13340	COG1309	transcriptional regulator
DUY81_13345	COG1846	Transcriptional regulator
DUY81_13350	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DUY81_13355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DUY81_13360	COG0084	hydrolase, TatD family'
DUY81_13375	COG2233	PERMEase
DUY81_13385	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DUY81_13390	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DUY81_13445	COG0693	protein deglycase activity
DUY81_13455	COG0789	Transcriptional regulator
DUY81_13485	COG1053	succinate dehydrogenase
DUY81_13510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DUY81_13580	COG2409	Drug exporters of the RND superfamily
DUY81_13630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DUY81_13645	COG1970	mechanosensitive ion channel activity
DUY81_13665	COG0673	inositol 2-dehydrogenase activity
DUY81_13670	COG2814	Major facilitator Superfamily
DUY81_13675	COG0673	inositol 2-dehydrogenase activity
DUY81_13690	COG3962	Belongs to the TPP enzyme family
DUY81_13695	COG3718	enzyme involved in inositol metabolism
DUY81_13705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DUY81_13710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DUY81_13715	COG3118	belongs to the thioredoxin family
DUY81_13720	COG2226	methyltransferase
DUY81_13725	COG1321	iron dependent repressor
DUY81_13750	COG2252	PERMEase
DUY81_13765	COG1278	Cold shock
DUY81_13770	COG0363	glucosamine-6-phosphate deaminase activity
DUY81_14005	COG0740	serine-type endopeptidase activity
DUY81_14125	COG0459	protein refolding
DUY81_14135	COG1482	cell wall glycoprotein biosynthetic process
DUY81_14140	COG1854	S-ribosylhomocysteine lyase activity
DUY81_14170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DUY81_14180	COG1648	precorrin-2 dehydrogenase activity
DUY81_14180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DUY81_14185	COG1797	cobyrinic acid a,c-diamide synthase activity
DUY81_14190	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DUY81_14215	COG0310	cobalt ion transport
DUY81_14230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DUY81_14230	COG1648	precorrin-2 dehydrogenase activity
DUY81_14250	COG1492	cobalamin metabolic process
DUY81_14255	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DUY81_14265	COG4585	Histidine kinase
DUY81_14285	COG0406	alpha-ribazole phosphatase activity
DUY81_14295	COG2197	response regulator
DUY81_14300	COG4585	Histidine kinase
DUY81_14310	COG1131	(ABC) transporter
DUY81_14315	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DUY81_14325	COG0156	8-amino-7-oxononanoate synthase activity
DUY81_14330	COG1063	alcohol dehydrogenase
DUY81_14335	COG0395	ABC-type sugar transport system, permease component
DUY81_14345	COG1653	transport
DUY81_14350	COG1940	carbohydrate kinase activity
DUY81_14355	COG1760	l-serine dehydratase
DUY81_14365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DUY81_14380	COG3842	ATPase activity
DUY81_14390	COG1484	DNA-dependent DNA replication
DUY81_14445	COG0626	cystathionine gamma-synthase activity
DUY81_14460	COG0215	cysteine-tRNA ligase activity
DUY81_14465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DUY81_14475	COG2814	Major facilitator Superfamily
DUY81_14480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DUY81_14500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DUY81_14505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DUY81_14520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DUY81_14530	COG3775	system Galactitol-specific IIC component
DUY81_14540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DUY81_14545	COG1329	Transcriptional regulator
DUY81_14560	COG5002	protein histidine kinase activity
DUY81_14565	COG0704	Plays a role in the regulation of phosphate uptake
DUY81_14570	COG0588	phosphoglycerate mutase activity
DUY81_14575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DUY81_14580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DUY81_14610	COG0191	fructose-bisphosphate aldolase activity
DUY81_14625	COG0586	Pfam SNARE associated Golgi protein
DUY81_14645	COG0489	protein tyrosine kinase activity
DUY81_14650	COG2244	polysaccharide biosynthetic process
DUY81_14680	COG0438	transferase activity, transferring glycosyl groups
DUY81_14700	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DUY81_14700	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DUY81_14705	COG1704	LemA family
DUY81_14725	COG0436	Aminotransferase
DUY81_14740	COG1174	glycine betaine transport
DUY81_14750	COG1174	glycine betaine transport
DUY81_14770	COG4176	ABC-type proline glycine betaine transport system permease component
DUY81_14775	COG0517	IMP dehydrogenase activity
DUY81_14775	COG4175	Glycine betaine
DUY81_14805	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DUY81_14815	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DUY81_14820	COG1609	Transcriptional regulator
DUY81_14825	COG2182	Extracellular solute-binding protein
DUY81_14830	COG1175	transmembrane transport
DUY81_14835	COG0395	ABC-type sugar transport system, permease component
DUY81_14850	COG0702	epimerase
DUY81_14855	COG1309	transcriptional regulator
DUY81_14865	COG1511	domain protein
DUY81_14880	COG1486	melibiose metabolic process
DUY81_14890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DUY81_14900	COG1175	transmembrane transport
DUY81_14905	COG0395	ABC-type sugar transport system, permease component
DUY81_14910	COG0542	response to heat
DUY81_14920	COG0395	ABC-type sugar transport system, permease component
DUY81_14935	COG2211	Major facilitator Superfamily
DUY81_14935	COG2190	(PTS) system
DUY81_14945	COG1609	Transcriptional regulator
DUY81_14950	COG3588	fructose-bisphosphate aldolase
DUY81_14965	COG4585	Histidine kinase
DUY81_14970	COG2197	response regulator
DUY81_14980	COG1136	(ABC) transporter
DUY81_14980	COG4591	ABC-type transport system involved in lipoprotein release permease component
DUY81_14985	COG1136	(ABC) transporter
DUY81_14985	COG0577	efflux transmembrane transporter activity
DUY81_14995	COG1113	amino acid transport
DUY81_15000	COG0569	domain protein
DUY81_15000	COG2985	domain, Protein
DUY81_15005	COG3527	Alpha-acetolactate decarboxylase
DUY81_15010	COG1063	alcohol dehydrogenase
DUY81_15015	COG0789	Transcriptional regulator
DUY81_15020	COG0484	heat shock protein binding
DUY81_15025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DUY81_15045	COG0745	RESPONSE REGULATOR receiver
DUY81_15050	COG2205	protein histidine kinase activity
DUY81_15055	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DUY81_15070	COG0574	Belongs to the PEP-utilizing enzyme family
DUY81_15070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DUY81_15075	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DUY81_15080	COG2813	Specifically methylates the guanine in position
DUY81_15085	COG0560	Phosphoserine phosphatase
DUY81_15085	COG3830	Belongs to the UPF0237 family
DUY81_15090	COG0676	glucose-6-phosphate 1-epimerase activity
DUY81_15105	COG1309	transcriptional regulator
DUY81_15110	COG1131	(ABC) transporter
DUY81_15125	COG2814	Major facilitator Superfamily
DUY81_15130	COG4608	Belongs to the ABC transporter superfamily
DUY81_15135	COG0154	amidase activity
DUY81_15180	COG1027	Aspartate ammonia-lyase
DUY81_15190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DUY81_15210	COG0673	inositol 2-dehydrogenase activity
DUY81_15220	COG1609	Transcriptional regulator
DUY81_15225	COG1609	Transcriptional regulator
DUY81_15265	COG1609	Transcriptional regulator
DUY81_15270	COG3254	rhamnose metabolic process
DUY81_15275	COG2814	Major facilitator Superfamily
DUY81_15280	COG4952	isomerase
DUY81_15285	COG1070	Carbohydrate kinase
DUY81_15295	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_15305	COG2814	Major facilitator Superfamily
DUY81_15325	COG0018	arginyl-trna synthetase
DUY81_15330	COG0656	L-ascorbic acid biosynthetic process
DUY81_15335	COG2814	Major facilitator Superfamily
DUY81_15350	COG0166	Belongs to the GPI family
DUY81_15360	COG4581	dead DEAH box helicase
DUY81_15370	COG1881	PFAM PEBP family protein
DUY81_15390	COG0667	Aldo Keto reductase
DUY81_15400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DUY81_15405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DUY81_15425	COG0583	DNA-binding transcription factor activity
DUY81_15430	COG2814	Major facilitator Superfamily
DUY81_15435	COG0861	Integral membrane protein TerC family
DUY81_15470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DUY81_15475	COG0561	phosphatase activity
DUY81_15480	COG0561	phosphatase activity
DUY81_15495	COG1136	(ABC) transporter
DUY81_15495	COG0577	efflux transmembrane transporter activity
DUY81_15520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DUY81_15525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DUY81_15570	COG1131	(ABC) transporter
DUY81_15575	COG1309	transcriptional regulator
DUY81_15580	COG1113	amino acid transport
DUY81_15590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DUY81_15595	COG1695	Transcriptional regulator
DUY81_15600	COG0477	Major facilitator Superfamily
DUY81_15655	COG1484	DNA-dependent DNA replication
DUY81_15675	COG0438	transferase activity, transferring glycosyl groups
DUY81_15685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DUY81_15690	COG0489	protein tyrosine kinase activity
DUY81_15700	COG1316	TRANSCRIPTIONal
DUY81_15720	COG0604	alcohol dehydrogenase
DUY81_15735	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DUY81_15740	COG1088	dTDP-glucose 4,6-dehydratase activity
DUY81_15750	COG1716	ATPase activity
DUY81_15755	COG1716	ATPase activity
DUY81_15770	COG0768	penicillin binding
DUY81_15775	COG0515	serine threonine protein kinase
DUY81_15795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DUY81_15800	COG0393	Putative heavy-metal-binding
DUY81_15810	COG1953	Uracil, thiamine, allantoin
DUY81_15815	COG1301	dicarboxylic acid transport
DUY81_15820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DUY81_15825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DUY81_15850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DUY81_15855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DUY81_15880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DUY81_15885	COG1309	transcriptional regulator
DUY81_15900	COG1609	Transcriptional regulator
DUY81_15910	COG0395	ABC-type sugar transport system, permease component
DUY81_15915	COG1653	transport
DUY81_15925	COG1454	alcohol dehydrogenase
DUY81_15930	COG2814	Major facilitator Superfamily
DUY81_15960	COG1271	oxidase subunit
DUY81_15965	COG1294	oxidase, subunit
DUY81_15970	COG4988	ABC transporter
DUY81_15975	COG1132	(ABC) transporter
DUY81_15985	COG1556	Lactate utilization protein
DUY81_15990	COG1139	Iron-sulfur cluster binding protein
DUY81_15995	COG0247	lactate metabolic process
DUY81_16000	COG1620	l-lactate permease
DUY81_16005	COG2186	Transcriptional regulator
DUY81_16020	COG1013	pyruvate-flavodoxin oxidoreductase activity
DUY81_16020	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DUY81_16020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DUY81_16020	COG0674	pyruvate-flavodoxin oxidoreductase activity
DUY81_16025	COG0167	dihydroorotate dehydrogenase activity
DUY81_16035	COG1083	cytidylyl-transferase
DUY81_16040	COG2089	acid synthase
DUY81_16070	COG0438	transferase activity, transferring glycosyl groups
DUY81_16095	COG0489	protein tyrosine kinase activity
DUY81_16145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DUY81_16160	COG1937	Protein conserved in bacteria
DUY81_16165	COG0305	Participates in initiation and elongation during chromosome replication
DUY81_16170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DUY81_16170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DUY81_16175	COG3118	belongs to the thioredoxin family
DUY81_16185	COG0386	Belongs to the glutathione peroxidase family
DUY81_16190	COG1846	Transcriptional regulator
DUY81_16210	COG2094	Belongs to the DNA glycosylase MPG family
DUY81_16225	COG1643	Atp-dependent helicase
DUY81_16240	COG2897	thiosulfate sulfurtransferase activity
DUY81_16280	COG0297	glycogen (starch) synthase activity
DUY81_16290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DUY81_16295	COG1126	abc transporter atp-binding protein
DUY81_16300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DUY81_16305	COG0765	amino acid transport
DUY81_16310	COG0765	amino acid transport
DUY81_16320	COG1105	Belongs to the carbohydrate kinase PfkB family
DUY81_16325	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DUY81_16325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DUY81_16325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DUY81_16355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DUY81_16390	COG0438	transferase activity, transferring glycosyl groups
DUY81_16395	COG0438	transferase activity, transferring glycosyl groups
DUY81_16480	COG2072	flavoprotein involved in K transport
DUY81_16505	COG1253	flavin adenine dinucleotide binding
DUY81_16535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DUY81_16550	COG1063	alcohol dehydrogenase
DUY81_16555	COG0586	Pfam SNARE associated Golgi protein
DUY81_16565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DUY81_16575	COG1119	ATPase activity
DUY81_16595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DUY81_16600	COG1609	Transcriptional regulator
DUY81_16605	COG0673	inositol 2-dehydrogenase activity
DUY81_16615	COG2186	Transcriptional regulator
DUY81_16625	COG5564	TIM-barrel signal transduction protein
DUY81_16655	COG2211	Major facilitator Superfamily