locus-tag	class	description
BWX38_00010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BWX38_00010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BWX38_00015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BWX38_00015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BWX38_00020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BWX38_00020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BWX38_00025	COG0509	glycine decarboxylation via glycine cleavage system
BWX38_00050	COG0714	Associated with various cellular activities
BWX38_00055	COG2001	Belongs to the MraZ family
BWX38_00060	COG0275	rRNA processing
BWX38_00070	COG0768	penicillin binding
BWX38_00080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BWX38_00085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BWX38_00090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BWX38_00095	COG0772	Belongs to the SEDS family
BWX38_00100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BWX38_00105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BWX38_00115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BWX38_00125	COG1799	cell septum assembly
BWX38_00140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BWX38_00155	COG0469	pyruvate kinase activity
BWX38_00170	COG2050	protein possibly involved in aromatic compounds catabolism
BWX38_00200	COG0539	negative regulation of cytoplasmic translation
BWX38_00205	COG0237	dephospho-CoA kinase activity
BWX38_00220	COG0556	nucleotide-excision repair
BWX38_00235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BWX38_00255	COG0322	excinuclease ABC activity
BWX38_00260	COG1660	Displays ATPase and GTPase activities
BWX38_00265	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BWX38_00270	COG1481	regulation of sporulation
BWX38_00275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BWX38_00280	COG0126	phosphoglycerate kinase activity
BWX38_00285	COG0149	triose-phosphate isomerase activity
BWX38_00290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BWX38_00300	COG0285	dihydrofolate synthase activity
BWX38_00310	COG0105	UTP biosynthetic process
BWX38_00320	COG1472	Belongs to the glycosyl hydrolase 3 family
BWX38_00330	COG1530	ribonuclease E activity
BWX38_00335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BWX38_00340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BWX38_00350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BWX38_00355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BWX38_00360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BWX38_00365	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BWX38_00445	COG0488	(ABC) transporter
BWX38_00520	COG0590	tRNA wobble adenosine to inosine editing
BWX38_00530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BWX38_00545	COG0495	leucyl-tRNA aminoacylation
BWX38_00555	COG0658	competence protein
BWX38_00555	COG2333	competence protein COMEC
BWX38_00560	COG1061	Type III restriction enzyme res subunit
BWX38_00570	COG0268	Binds directly to 16S ribosomal RNA
BWX38_00580	COG0481	GTPase activity
BWX38_00600	COG4948	Mandelate Racemase Muconate Lactonizing
BWX38_00605	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BWX38_00610	COG1169	isochorismate synthase
BWX38_00620	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BWX38_00630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BWX38_00635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BWX38_00655	COG1309	transcriptional regulator
BWX38_00660	COG0477	Major facilitator Superfamily
BWX38_00670	COG0395	ABC-type sugar transport system, permease component
BWX38_00675	COG1175	transmembrane transport
BWX38_00695	COG0483	inositol monophosphate 1-phosphatase activity
BWX38_00705	COG1420	regulation of RNA biosynthetic process
BWX38_00710	COG0484	heat shock protein binding
BWX38_00720	COG1063	alcohol dehydrogenase
BWX38_00725	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BWX38_00725	COG2213	PTS system mannitol-specific
BWX38_00740	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BWX38_00745	COG5006	permease, DMT superfamily
BWX38_00750	COG0343	queuine tRNA-ribosyltransferase activity
BWX38_00760	COG2197	response regulator
BWX38_00765	COG4152	abc transporter atp-binding protein
BWX38_00805	COG2226	methyltransferase
BWX38_00825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BWX38_00835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BWX38_00845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BWX38_00850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWX38_00855	COG0765	amino acid transport
BWX38_00860	COG0765	amino acid transport
BWX38_00870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BWX38_00880	COG1404	Belongs to the peptidase S8 family
BWX38_00885	COG1381	Involved in DNA repair and RecF pathway recombination
BWX38_00890	COG1063	alcohol dehydrogenase
BWX38_00895	COG4716	Myosin-crossreactive antigen
BWX38_00925	COG0735	belongs to the Fur family
BWX38_00935	COG0423	glycine-tRNA ligase activity
BWX38_00945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BWX38_00950	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BWX38_00960	COG0076	glutamate decarboxylase activity
BWX38_00970	COG1053	succinate dehydrogenase
BWX38_01000	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BWX38_01005	COG0358	DNA primase activity
BWX38_01010	COG1191	sigma factor activity
BWX38_01035	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BWX38_01055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BWX38_01065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BWX38_01075	COG0583	DNA-binding transcription factor activity
BWX38_01085	COG0515	serine threonine protein kinase
BWX38_01090	COG1309	transcriptional regulator
BWX38_01095	COG0477	Major facilitator Superfamily
BWX38_01125	COG0714	Associated with various cellular activities
BWX38_01135	COG2304	oxidoreductase activity
BWX38_01160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BWX38_01165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BWX38_01175	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BWX38_01190	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BWX38_01200	COG0667	Aldo Keto reductase
BWX38_01215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BWX38_01220	COG0505	Belongs to the CarA family
BWX38_01225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BWX38_01230	COG0543	2 iron, 2 sulfur cluster binding
BWX38_01235	COG0167	dihydroorotate dehydrogenase activity
BWX38_01240	COG0284	orotidine-5'-phosphate decarboxylase activity
BWX38_01245	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BWX38_01275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWX38_01285	COG1546	Belongs to the CinA family
BWX38_01285	COG1058	Belongs to the CinA family
BWX38_01295	COG1349	DNA-binding transcription factor activity
BWX38_01310	COG2137	regulation of response to DNA damage stimulus
BWX38_01315	COG1418	mRNA catabolic process
BWX38_01325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWX38_01335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BWX38_01340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BWX38_01345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BWX38_01360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BWX38_01365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BWX38_01370	COG0717	Belongs to the dCTP deaminase family
BWX38_01390	COG1643	Atp-dependent helicase
BWX38_01400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BWX38_01415	COG0187	DNA topoisomerase II activity
BWX38_01435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BWX38_01445	COG1297	OPT oligopeptide transporter protein
BWX38_01480	COG0756	dUTP diphosphatase activity
BWX38_01500	COG0569	domain protein
BWX38_01505	COG0531	amino acid
BWX38_01510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BWX38_01520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BWX38_01525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BWX38_01540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWX38_01545	COG2326	polyphosphate kinase activity
BWX38_01575	COG0726	polysaccharide deacetylase
BWX38_01605	COG1064	alcohol dehydrogenase
BWX38_01610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BWX38_01625	COG1560	Kdo2-lipid A biosynthetic process
BWX38_01630	COG0438	transferase activity, transferring glycosyl groups
BWX38_01660	COG1716	ATPase activity
BWX38_01680	COG1295	ribonuclease BN
BWX38_01685	COG0205	6-phosphofructokinase activity
BWX38_01695	COG0009	L-threonylcarbamoyladenylate synthase
BWX38_01710	COG1472	Belongs to the glycosyl hydrolase 3 family
BWX38_01715	COG1739	Uncharacterized protein family UPF0029
BWX38_01730	COG0443	Heat shock 70 kDa protein
BWX38_01765	COG0531	amino acid
BWX38_01780	COG1966	Carbon starvation protein
BWX38_01790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BWX38_01795	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BWX38_01810	COG1216	Glycosyl transferase, family 2
BWX38_01815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BWX38_01820	COG1522	sequence-specific DNA binding
BWX38_01825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BWX38_01825	COG2813	Specifically methylates the guanine in position
BWX38_01830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BWX38_01835	COG0427	acetyl-CoA hydrolase
BWX38_01860	COG2807	transmembrane transport
BWX38_01890	COG3550	peptidyl-serine autophosphorylation
BWX38_01950	COG0277	FAD linked oxidase domain protein
BWX38_01960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BWX38_01980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BWX38_01990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BWX38_02020	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BWX38_02060	COG1764	response to oxidative stress
BWX38_02070	COG1160	GTP binding
BWX38_02075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BWX38_02085	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BWX38_02090	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BWX38_02105	COG0646	methionine synthase
BWX38_02105	COG1410	methionine synthase
BWX38_02115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BWX38_02125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BWX38_02160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BWX38_02165	COG1201	RNA secondary structure unwinding
BWX38_02170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BWX38_02180	COG1758	RNA polymerase activity
BWX38_02185	COG0194	GDP metabolic process
BWX38_02195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BWX38_02200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BWX38_02210	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BWX38_02215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BWX38_02220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BWX38_02225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BWX38_02230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BWX38_02235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BWX38_02240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BWX38_02275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BWX38_02290	COG1309	transcriptional regulator
BWX38_02300	COG0124	histidyl-tRNA synthetase
BWX38_02305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWX38_02310	COG1196	nuclear chromosome segregation
BWX38_02315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BWX38_02320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BWX38_02330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BWX38_02335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BWX38_02340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BWX38_02350	COG2255	four-way junction helicase activity
BWX38_02355	COG0632	four-way junction helicase activity
BWX38_02360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BWX38_02365	COG0217	transcriptional regulatory protein
BWX38_02370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BWX38_02375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BWX38_02380	COG0131	Imidazoleglycerol-phosphate dehydratase
BWX38_02385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BWX38_02390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BWX38_02425	COG0395	ABC-type sugar transport system, permease component
BWX38_02445	COG0067	glutamate synthase
BWX38_02445	COG0070	glutamate synthase
BWX38_02445	COG0069	glutamate synthase activity
BWX38_02450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BWX38_02455	COG0159	tryptophan synthase activity
BWX38_02465	COG0134	indole-3-glycerol-phosphate synthase activity
BWX38_02480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BWX38_02485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BWX38_02500	COG2233	PERMEase
BWX38_02505	COG2233	PERMEase
BWX38_02510	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BWX38_02515	COG0154	amidase activity
BWX38_02520	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BWX38_02545	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BWX38_02560	COG0482	sulfurtransferase activity
BWX38_02585	COG0366	Alpha amylase catalytic
BWX38_02590	COG3281	Trehalose synthase
BWX38_02595	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BWX38_02610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BWX38_02620	COG0033	Phosphoglucomutase
BWX38_02675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BWX38_02680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BWX38_02685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BWX38_02690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BWX38_02695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BWX38_02700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BWX38_02705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BWX38_02710	COG0356	it plays a direct role in the translocation of protons across the membrane
BWX38_02725	COG1045	serine acetyltransferase
BWX38_02735	COG0367	asparagine synthase
BWX38_02740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BWX38_02750	COG0318	PFAM AMP-dependent synthetase and ligase
BWX38_02835	COG2890	protein-(glutamine-N5) methyltransferase activity
BWX38_02840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BWX38_02845	COG0254	rRNA binding
BWX38_02855	COG0083	homoserine kinase activity
BWX38_02860	COG0460	homoserine dehydrogenase
BWX38_02865	COG0019	diaminopimelate decarboxylase activity
BWX38_02875	COG1611	Belongs to the LOG family
BWX38_02885	COG0567	Dehydrogenase, E1 component
BWX38_02885	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWX38_02910	COG1595	DNA-templated transcription, initiation
BWX38_02920	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BWX38_02925	COG1162	GTPase activity
BWX38_02935	COG0483	inositol monophosphate 1-phosphatase activity
BWX38_02940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BWX38_02965	COG0747	negative chemotaxis
BWX38_02995	COG1615	UPF0182 protein
BWX38_03005	COG3480	Lon protease (S16) C-terminal proteolytic domain
BWX38_03030	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BWX38_03035	COG1074	ATP-dependent DNA helicase activity
BWX38_03040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BWX38_03055	COG0210	DNA helicase
BWX38_03060	COG1278	Cold shock
BWX38_03085	COG0180	Tryptophanyl-tRNA synthetase
BWX38_03095	COG0613	PHP domain protein
BWX38_03115	COG0653	protein targeting
BWX38_03125	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BWX38_03135	COG5401	PFAM Sporulation and spore germination
BWX38_03140	COG5002	protein histidine kinase activity
BWX38_03145	COG0745	RESPONSE REGULATOR receiver
BWX38_03150	COG1678	Uncharacterized ACR, COG1678
BWX38_03165	COG0165	Argininosuccinate lyase
BWX38_03170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BWX38_03180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BWX38_03190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BWX38_03195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BWX38_03200	COG2177	Part of the ABC transporter FtsEX involved in
BWX38_03205	COG2884	Cell division ATP-binding protein ftsE
BWX38_03210	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BWX38_03225	COG3152	Membrane
BWX38_03235	COG1674	ftsk spoiiie
BWX38_03245	COG2801	Transposase and inactivated derivatives
BWX38_03255	COG1181	Belongs to the D-alanine--D-alanine ligase family
BWX38_03265	COG0066	3-isopropylmalate dehydratase activity
BWX38_03270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BWX38_03275	COG1414	Transcriptional regulator
BWX38_03295	COG0179	Fumarylacetoacetate (FAA) hydrolase
BWX38_03305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BWX38_03310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BWX38_03335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BWX38_03340	COG0440	acetolactate synthase activity
BWX38_03350	COG0537	adenosine 5'-monophosphoramidase activity
BWX38_03355	COG0107	imidazoleglycerol-phosphate synthase activity
BWX38_03375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BWX38_03395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWX38_03430	COG0504	CTP synthase activity
BWX38_03435	COG0497	DNA recombination
BWX38_03440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BWX38_03455	COG1122	ATPase activity
BWX38_03460	COG1268	BioY protein
BWX38_03465	COG0647	UMP catabolic process
BWX38_03500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BWX38_03505	COG0140	phosphoribosyl-ATP diphosphatase activity
BWX38_03510	COG3201	nicotinamide mononucleotide transporter
BWX38_03520	COG0667	Aldo Keto reductase
BWX38_03530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWX38_03555	COG2801	Transposase and inactivated derivatives
BWX38_03555	COG3415	Transposase
BWX38_03570	COG1609	Transcriptional regulator
BWX38_03575	COG2160	L-arabinose isomerase activity
BWX38_03605	COG0395	ABC-type sugar transport system, permease component
BWX38_03615	COG1609	Transcriptional regulator
BWX38_03620	COG0395	ABC-type sugar transport system, permease component
BWX38_03650	COG0606	chelatase, subunit chli
BWX38_03655	COG0792	nuclease activity
BWX38_03665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BWX38_03670	COG0681	Belongs to the peptidase S26 family
BWX38_03675	COG0335	large ribosomal subunit rRNA binding
BWX38_03680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BWX38_03685	COG1053	succinate dehydrogenase
BWX38_03695	COG0336	Belongs to the RNA methyltransferase TrmD family
BWX38_03700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BWX38_03705	COG1837	Belongs to the UPF0109 family
BWX38_03710	COG0228	four-way junction DNA binding
BWX38_03785	COG0656	L-ascorbic acid biosynthetic process
BWX38_03790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BWX38_03795	COG0571	ribonuclease III activity
BWX38_03800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BWX38_03810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BWX38_03815	COG0742	ribosomal rna small subunit methyltransferase
BWX38_03835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BWX38_03840	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BWX38_03850	COG0028	Belongs to the TPP enzyme family
BWX38_03860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BWX38_03865	COG1185	polyribonucleotide nucleotidyltransferase activity
BWX38_03870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BWX38_03890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BWX38_03910	COG3732	PTS system glucitol sorbitol-specific
BWX38_03925	COG0371	Dehydrogenase
BWX38_03930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BWX38_03935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BWX38_03940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BWX38_03955	COG0779	Required for maturation of 30S ribosomal subunits
BWX38_03975	COG0442	prolyl-tRNA aminoacylation
BWX38_03985	COG1305	Transglutaminase-like
BWX38_04015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BWX38_04020	COG0750	zinc metalloprotease
BWX38_04030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BWX38_04035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BWX38_04040	COG0575	Belongs to the CDS family
BWX38_04045	COG0233	cytoplasmic translational termination
BWX38_04050	COG0528	UMP kinase activity
BWX38_04055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BWX38_04060	COG0052	Belongs to the universal ribosomal protein uS2 family
BWX38_04070	COG3831	ATPase activity
BWX38_04075	COG0714	Associated with various cellular activities
BWX38_04085	COG3552	Protein containing von Willebrand factor type A (VWA) domain
BWX38_04100	COG4974	Belongs to the 'phage' integrase family
BWX38_04110	COG0242	peptide deformylase activity
BWX38_04150	COG1119	ATPase activity
BWX38_04155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BWX38_04180	COG1028	Short-chain dehydrogenase reductase Sdr
BWX38_04210	COG0488	(ABC) transporter
BWX38_04260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BWX38_04265	COG0396	ATPase activity
BWX38_04280	COG0719	Fe-S assembly protein
BWX38_04295	COG1175	transmembrane transport
BWX38_04300	COG3833	ABC-type maltose transport systems, permease component
BWX38_04305	COG1609	Transcriptional regulator
BWX38_04310	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BWX38_04315	COG1131	(ABC) transporter
BWX38_04325	COG1612	heme a metabolic process
BWX38_04330	COG0109	protoheme IX farnesyltransferase activity
BWX38_04345	COG0363	glucosamine-6-phosphate deaminase activity
BWX38_04355	COG0525	valine-tRNA ligase activity
BWX38_04370	COG0793	Belongs to the peptidase S41A family
BWX38_04370	COG4946	Tricorn protease homolog
BWX38_04380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BWX38_04385	COG0740	serine-type endopeptidase activity
BWX38_04390	COG0740	serine-type endopeptidase activity
BWX38_04400	COG0544	peptidyl-prolyl cis-trans isomerase activity
BWX38_04420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BWX38_04420	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BWX38_04440	COG0698	ribose 5-phosphate isomerase
BWX38_04455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BWX38_04460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BWX38_04475	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BWX38_04485	COG2814	Major facilitator Superfamily
BWX38_04500	COG1022	Amp-dependent synthetase and ligase
BWX38_04515	COG0277	FAD linked oxidase domain protein
BWX38_04515	COG0247	lactate metabolic process
BWX38_04540	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BWX38_04545	COG2801	Transposase and inactivated derivatives
BWX38_04555	COG4106	trans-aconitate 2-methyltransferase activity
BWX38_04565	COG0519	Catalyzes the synthesis of GMP from XMP
BWX38_04570	COG1794	racemase activity, acting on amino acids and derivatives
BWX38_04590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BWX38_04630	COG1794	racemase activity, acting on amino acids and derivatives
BWX38_04635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BWX38_04640	COG0384	phenazine biosynthesis protein PhzF
BWX38_04645	COG2226	methyltransferase
BWX38_04660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BWX38_04665	COG2197	response regulator
BWX38_04670	COG4585	Histidine kinase
BWX38_04680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BWX38_04690	COG1113	amino acid transport
BWX38_04705	COG1131	(ABC) transporter
BWX38_04725	COG2855	membrane
BWX38_04730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BWX38_04735	COG0531	amino acid
BWX38_04745	COG0587	DNA-directed DNA polymerase activity
BWX38_04760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BWX38_04785	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BWX38_04810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BWX38_04815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BWX38_04820	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BWX38_04825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BWX38_04830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BWX38_04835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BWX38_04845	COG1918	ferrous iron import across plasma membrane
BWX38_04845	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BWX38_04860	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BWX38_04900	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BWX38_04950	COG0662	Cupin 2, conserved barrel domain protein
BWX38_04950	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BWX38_04965	COG1316	TRANSCRIPTIONal
BWX38_04985	COG3340	Belongs to the peptidase S51 family
BWX38_04995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BWX38_05005	COG0424	maF-like protein
BWX38_05020	COG4221	oxidoreductase activity
BWX38_05030	COG0351	phosphomethylpyrimidine kinase
BWX38_05040	COG4770	biotin carboxylase activity
BWX38_05060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BWX38_05075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BWX38_05080	COG4656	Part of a membrane complex involved in electron transport
BWX38_05095	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BWX38_05115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWX38_05155	COG1253	flavin adenine dinucleotide binding
BWX38_05175	COG0039	L-malate dehydrogenase activity
BWX38_05190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BWX38_05200	COG0138	bifunctional purine biosynthesis protein purh
BWX38_05210	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BWX38_05215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BWX38_05215	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BWX38_05245	COG0045	succinate-CoA ligase (ADP-forming) activity
BWX38_05260	COG2801	Transposase and inactivated derivatives
BWX38_05270	COG1464	Belongs to the NlpA lipoprotein family
BWX38_05275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BWX38_05280	COG2011	ABC-type metal ion transport system permease component
BWX38_05290	COG2261	transglycosylase associated protein
BWX38_05295	COG2197	response regulator
BWX38_05320	COG0519	Catalyzes the synthesis of GMP from XMP
BWX38_05320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BWX38_05325	COG1045	serine acetyltransferase
BWX38_05330	COG1605	Chorismate mutase
BWX38_05330	COG0287	Prephenate dehydrogenase
BWX38_05350	COG0459	protein refolding
BWX38_05355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BWX38_05375	COG1355	regulation of microtubule-based process
BWX38_05395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BWX38_05405	COG0456	acetyltransferase
BWX38_05405	COG1214	PFAM Peptidase M22, glycoprotease
BWX38_05410	COG0802	atpase or kinase
BWX38_05415	COG0513	Belongs to the DEAD box helicase family
BWX38_05430	COG0736	holo-[acyl-carrier-protein] synthase activity
BWX38_05435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BWX38_05445	COG1072	(Pantothenic acid kinase))
BWX38_05455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BWX38_05465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BWX38_05470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BWX38_05490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BWX38_05495	COG0101	tRNA pseudouridine synthase activity
BWX38_05510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BWX38_05515	COG3845	ABC transporter
BWX38_05530	COG0519	Catalyzes the synthesis of GMP from XMP
BWX38_05530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BWX38_05540	COG0438	transferase activity, transferring glycosyl groups
BWX38_05545	COG0203	ribosomal protein L17
BWX38_05550	COG0202	RNA polymerase activity
BWX38_05555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BWX38_05560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BWX38_05565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BWX38_05570	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BWX38_05575	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BWX38_05595	COG0563	adenylate kinase activity
BWX38_05630	COG0200	Binds to the 23S rRNA
BWX38_05635	COG1841	ribosomal large subunit assembly
BWX38_05640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BWX38_05645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BWX38_05650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BWX38_05655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BWX38_05660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BWX38_05665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BWX38_05670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BWX38_05675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BWX38_05680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BWX38_05685	COG0395	ABC-type sugar transport system, permease component
BWX38_05690	COG1175	transmembrane transport
BWX38_05710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BWX38_05715	COG0255	Belongs to the universal ribosomal protein uL29 family
BWX38_05720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BWX38_05725	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BWX38_05730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BWX38_05735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BWX38_05740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BWX38_05745	COG0089	rRNA binding
BWX38_05750	COG0088	Forms part of the polypeptide exit tunnel
BWX38_05755	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BWX38_05760	COG0051	transcription antitermination factor activity, RNA binding
BWX38_05765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWX38_05770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWX38_05785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BWX38_05790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BWX38_05795	COG0049	tRNA binding
BWX38_05800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BWX38_05805	COG0673	inositol 2-dehydrogenase activity
BWX38_05825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BWX38_05830	COG0085	RNA polymerase activity
BWX38_05835	COG0222	ribosome binding
BWX38_05845	COG0081	regulation of translation
BWX38_05850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BWX38_05855	COG0250	Participates in transcription elongation, termination and antitermination
BWX38_05870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BWX38_05875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BWX38_05885	COG2030	dehydratase
BWX38_05890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BWX38_05930	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWX38_05935	COG0649	NAD binding
BWX38_05935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWX38_05940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWX38_05945	COG0674	pyruvate-flavodoxin oxidoreductase activity
BWX38_05945	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BWX38_05950	COG1013	pyruvate-flavodoxin oxidoreductase activity
BWX38_05955	COG3590	peptidase
BWX38_06015	COG1007	ATP synthesis coupled electron transport
BWX38_06030	COG0713	ATP synthesis coupled electron transport
BWX38_06040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWX38_06045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BWX38_06050	COG1034	ATP synthesis coupled electron transport
BWX38_06055	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BWX38_06065	COG0649	NAD binding
BWX38_06070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWX38_06075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWX38_06085	COG0644	oxidoreductase
BWX38_06115	COG1131	(ABC) transporter
BWX38_06120	COG2226	methyltransferase
BWX38_06130	COG1132	(ABC) transporter
BWX38_06150	COG2376	Dihydroxyacetone kinase
BWX38_06155	COG1461	Dihydroxyacetone kinase
BWX38_06160	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BWX38_06160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BWX38_06160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BWX38_06175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BWX38_06180	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BWX38_06200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BWX38_06210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BWX38_06255	COG0574	Belongs to the PEP-utilizing enzyme family
BWX38_06255	COG3848	Pyruvate phosphate dikinase
BWX38_06270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BWX38_06390	COG0395	ABC-type sugar transport system, permease component
BWX38_06415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BWX38_06455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BWX38_06470	COG0252	asparaginase activity
BWX38_06475	COG1113	amino acid transport
BWX38_06485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BWX38_06490	COG0047	phosphoribosylformylglycinamidine synthase activity
BWX38_06495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BWX38_06500	COG0450	alkyl hydroperoxide reductase
BWX38_06505	COG3634	alkyl hydroperoxide reductase activity
BWX38_06515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BWX38_06520	COG0151	Belongs to the GarS family
BWX38_06525	COG4423	Transcription factor
BWX38_06530	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
BWX38_06535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BWX38_06550	COG1937	Protein conserved in bacteria
BWX38_06555	COG0446	pyridine nucleotide-disulphide oxidoreductase
BWX38_06570	COG2337	Toxic component of a toxin-antitoxin (TA) module
BWX38_06585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BWX38_06595	COG3485	protocatechuate 3,4-dioxygenase
BWX38_06600	COG1490	D-aminoacyl-tRNA deacylase activity
BWX38_06630	COG0745	RESPONSE REGULATOR receiver
BWX38_06635	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BWX38_06660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BWX38_06665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BWX38_06680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BWX38_06685	COG0254	rRNA binding
BWX38_06690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BWX38_06700	COG0523	cobalamin synthesis protein
BWX38_06710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWX38_06715	COG1121	(ABC) transporter
BWX38_06725	COG0803	Belongs to the bacterial solute-binding protein 9 family
BWX38_06730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BWX38_06735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BWX38_06740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BWX38_06745	COG1120	ATPase activity
BWX38_06765	COG0129	dihydroxy-acid dehydratase activity
BWX38_06770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BWX38_06780	COG2409	Drug exporters of the RND superfamily
BWX38_06785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BWX38_06800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BWX38_06810	COG0785	Cytochrome C biogenesis protein
BWX38_06815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWX38_06820	COG0406	alpha-ribazole phosphatase activity
BWX38_06825	COG1648	precorrin-2 dehydrogenase activity
BWX38_06825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BWX38_06830	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BWX38_06845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BWX38_06860	COG0506	proline dehydrogenase activity
BWX38_06865	COG1082	Xylose isomerase domain protein TIM barrel
BWX38_06875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWX38_06880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BWX38_06885	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BWX38_06900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BWX38_06905	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BWX38_06915	COG0181	hydroxymethylbilane synthase activity
BWX38_06925	COG0113	porphobilinogen synthase activity
BWX38_06930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BWX38_06935	COG1194	a g-specific adenine glycosylase
BWX38_06945	COG3842	ATPase activity
BWX38_06955	COG4143	(ABC) transporter
BWX38_06960	COG0572	uridine kinase
BWX38_06965	COG0705	Rhomboid family
BWX38_06965	COG0457	Tetratricopeptide repeat
BWX38_07025	COG0542	response to heat
BWX38_07035	COG2801	Transposase and inactivated derivatives
BWX38_07040	COG0649	NAD binding
BWX38_07055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BWX38_07060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BWX38_07065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BWX38_07070	COG0302	gtp cyclohydrolase
BWX38_07085	COG0037	tRNA processing
BWX38_07095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BWX38_07105	COG3458	cephalosporin-C deacetylase activity
BWX38_07110	COG2062	phosphohistidine phosphatase, SixA
BWX38_07155	COG1522	sequence-specific DNA binding
BWX38_07160	COG1619	proteins homologs of microcin C7 resistance protein MccF
BWX38_07170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWX38_07175	COG0601	transmembrane transport
BWX38_07205	COG0431	NADPH-dependent FMN reductase
BWX38_07210	COG1231	oxidoreductase activity
BWX38_07250	COG1774	PSP1 C-terminal conserved region
BWX38_07260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BWX38_07265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BWX38_07275	COG1754	DNA topoisomerase type I activity
BWX38_07275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BWX38_07285	COG2890	protein-(glutamine-N5) methyltransferase activity
BWX38_07290	COG1111	helicase
BWX38_07290	COG1205	dead DEAH box helicase
BWX38_07375	COG0494	nUDIX hydrolase
BWX38_07405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BWX38_07410	COG1408	metallophosphoesterase
BWX38_07435	COG2040	homocysteine
BWX38_07440	COG1846	Transcriptional regulator
BWX38_07470	COG0601	transmembrane transport
BWX38_07475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWX38_07480	COG0444	Belongs to the ABC transporter superfamily
BWX38_07485	COG4608	Belongs to the ABC transporter superfamily
BWX38_07500	COG3022	response to hydroperoxide
BWX38_07515	COG1069	ribulokinase activity
BWX38_07520	COG1072	(Pantothenic acid kinase))
BWX38_07535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BWX38_07545	COG0534	Mate efflux family protein
BWX38_07550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BWX38_07605	COG2197	response regulator
BWX38_07630	COG3285	dna ligase
BWX38_07630	COG1793	dna ligase
BWX38_07635	COG2124	cytochrome p450
BWX38_07640	COG1028	Short-chain dehydrogenase reductase Sdr
BWX38_07650	COG0783	Belongs to the Dps family
BWX38_07655	COG1028	Short-chain dehydrogenase reductase Sdr
BWX38_07670	COG1295	ribonuclease BN
BWX38_07690	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BWX38_07710	COG4572	Cation transport regulator
BWX38_07715	COG0667	Aldo Keto reductase
BWX38_07735	COG3158	transport of potassium into the cell
BWX38_07770	COG0477	Major facilitator Superfamily
BWX38_07775	COG0445	tRNA wobble uridine modification
BWX38_07785	COG0586	Pfam SNARE associated Golgi protein
BWX38_07795	COG0438	transferase activity, transferring glycosyl groups
BWX38_07805	COG0745	RESPONSE REGULATOR receiver
BWX38_07810	COG1968	undecaprenyl-diphosphatase activity
BWX38_07820	COG0390	transport system, permease component
BWX38_07830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BWX38_07840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BWX38_07855	COG4221	oxidoreductase activity
BWX38_07880	COG1653	transport
BWX38_07885	COG1175	transmembrane transport
BWX38_07890	COG0395	ABC-type sugar transport system, permease component
BWX38_07900	COG1609	Transcriptional regulator
BWX38_07905	COG1069	ribulokinase activity
BWX38_07910	COG1064	alcohol dehydrogenase
BWX38_07920	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BWX38_07925	COG1063	alcohol dehydrogenase
BWX38_07935	COG1946	Acyl-CoA thioesterase
BWX38_07945	COG0673	inositol 2-dehydrogenase activity
BWX38_07950	COG1942	4-Oxalocrotonate Tautomerase
BWX38_07980	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BWX38_08000	COG0433	COG0433 Predicted ATPase
BWX38_08015	COG3263	regulation of cellular component size
BWX38_08020	COG1125	glycine betaine transport
BWX38_08020	COG0517	IMP dehydrogenase activity
BWX38_08030	COG1174	glycine betaine transport
BWX38_08040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BWX38_08090	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BWX38_08115	COG2130	NADP-dependent
BWX38_08120	COG0823	Involved in the tonB-independent uptake of proteins
BWX38_08120	COG1506	peptidase
BWX38_08120	COG4946	Tricorn protease homolog
BWX38_08125	COG0584	glycerophosphoryl diester phosphodiesterase
BWX38_08150	COG1316	TRANSCRIPTIONal
BWX38_08155	COG1609	Transcriptional regulator
BWX38_08160	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BWX38_08185	COG1028	Short-chain dehydrogenase reductase Sdr
BWX38_08185	COG3321	synthase
BWX38_08185	COG0604	alcohol dehydrogenase
BWX38_08190	COG0137	argininosuccinate synthase activity
BWX38_08210	COG0561	phosphatase activity
BWX38_08230	COG3833	ABC-type maltose transport systems, permease component
BWX38_08250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BWX38_08270	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BWX38_08280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BWX38_08290	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWX38_08295	COG0022	dehydrogenase e1 component
BWX38_08305	COG1233	COG1233 Phytoene dehydrogenase and related
BWX38_08350	COG0477	Major facilitator Superfamily
BWX38_08360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BWX38_08365	COG0006	proline dipeptidase activity
BWX38_08415	COG0154	amidase activity
BWX38_08420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWX38_08435	COG1126	abc transporter atp-binding protein
BWX38_08440	COG0765	amino acid transport
BWX38_08445	COG0765	amino acid transport
BWX38_08490	COG1715	Restriction endonuclease
BWX38_08520	COG5002	protein histidine kinase activity
BWX38_08535	COG1621	beta-fructofuranosidase activity
BWX38_08540	COG2390	Transcriptional regulator
BWX38_08560	COG0235	Class ii aldolase
BWX38_08565	COG0656	L-ascorbic acid biosynthetic process
BWX38_08570	COG1830	Aldolase
BWX38_08575	COG1063	alcohol dehydrogenase
BWX38_08585	COG0477	Major facilitator Superfamily
BWX38_08640	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BWX38_08685	COG0366	Alpha amylase catalytic
BWX38_08695	COG1653	transport
BWX38_08700	COG0395	ABC-type sugar transport system, permease component
BWX38_08705	COG1175	transmembrane transport
BWX38_08710	COG1285	pathogenesis
BWX38_08745	COG0395	ABC-type sugar transport system, permease component
BWX38_08750	COG0366	Alpha amylase catalytic
BWX38_08765	COG1132	(ABC) transporter
BWX38_08770	COG1132	(ABC) transporter
BWX38_08785	COG2423	ornithine cyclodeaminase activity
BWX38_08805	COG0395	ABC-type sugar transport system, permease component
BWX38_08810	COG1175	transmembrane transport
BWX38_08820	COG1609	Transcriptional regulator
BWX38_08835	COG2205	protein histidine kinase activity
BWX38_08845	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BWX38_08870	COG1902	pentaerythritol trinitrate reductase activity
BWX38_08875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BWX38_08885	COG1968	undecaprenyl-diphosphatase activity
BWX38_08900	COG0359	binds to the 23S rRNA
BWX38_08905	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BWX38_08915	COG0360	Binds together with S18 to 16S ribosomal RNA
BWX38_08920	COG2837	iron assimilation
BWX38_08930	COG0672	)-iron permease
BWX38_08940	COG1022	Amp-dependent synthetase and ligase
BWX38_08955	COG0300	oxidoreductase activity
BWX38_09000	COG0277	FAD linked oxidase domain protein
BWX38_09010	COG2197	response regulator
BWX38_09015	COG1051	belongs to the nudix hydrolase family
BWX38_09020	COG1131	(ABC) transporter
BWX38_09045	COG1136	(ABC) transporter
BWX38_09045	COG0577	efflux transmembrane transporter activity
BWX38_09055	COG0247	lactate metabolic process
BWX38_09060	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
BWX38_09065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BWX38_09070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWX38_09075	COG1846	Transcriptional regulator
BWX38_09085	COG1113	amino acid transport
BWX38_09155	COG0534	Mate efflux family protein
BWX38_09170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BWX38_09180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BWX38_09190	COG1175	transmembrane transport
BWX38_09215	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BWX38_09245	COG2337	Toxic component of a toxin-antitoxin (TA) module
BWX38_09250	COG3609	addiction module antidote protein, CC2985 family
BWX38_09265	COG2146	nitrite reductase [NAD(P)H] activity
BWX38_09275	COG1716	ATPase activity
BWX38_09275	COG0842	Transport permease protein
BWX38_09275	COG1131	(ABC) transporter
BWX38_09280	COG0515	serine threonine protein kinase
BWX38_09290	COG0205	6-phosphofructokinase activity
BWX38_09295	COG0686	Belongs to the AlaDH PNT family
BWX38_09300	COG2267	carboxylic ester hydrolase activity
BWX38_09345	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BWX38_09355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BWX38_09395	COG0038	chloride channel
BWX38_09405	COG2848	UPF0210 protein
BWX38_09410	COG3830	Belongs to the UPF0237 family
BWX38_09420	COG0114	fumarate hydratase activity
BWX38_09425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BWX38_09445	COG1131	(ABC) transporter
BWX38_09460	COG2814	Major facilitator Superfamily
BWX38_09470	COG1349	DNA-binding transcription factor activity
BWX38_09475	COG0540	Belongs to the ATCase OTCase family
BWX38_09490	COG0668	transmembrane transport
BWX38_09500	COG1929	Belongs to the glycerate kinase type-1 family
BWX38_09510	COG0617	tRNA 3'-terminal CCA addition
BWX38_09515	COG1012	belongs to the aldehyde dehydrogenase family
BWX38_09520	COG0385	Bile acid
BWX38_09555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BWX38_09560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BWX38_09565	COG2390	Transcriptional regulator
BWX38_09575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BWX38_09590	COG0395	ABC-type sugar transport system, permease component
BWX38_09600	COG1653	transport
BWX38_09610	COG1609	Transcriptional regulator
BWX38_09620	COG1733	regulation of RNA biosynthetic process
BWX38_09630	COG0564	pseudouridine synthase activity
BWX38_09650	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BWX38_09650	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BWX38_09665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BWX38_09675	COG1082	Xylose isomerase domain protein TIM barrel
BWX38_09685	COG1609	Transcriptional regulator
BWX38_09695	COG2855	membrane
BWX38_09705	COG0673	inositol 2-dehydrogenase activity
BWX38_09715	COG0673	inositol 2-dehydrogenase activity
BWX38_09720	COG2814	Major facilitator Superfamily
BWX38_09725	COG1609	Transcriptional regulator
BWX38_09730	COG2814	Major facilitator Superfamily
BWX38_09740	COG1082	Xylose isomerase domain protein TIM barrel
BWX38_09745	COG0673	inositol 2-dehydrogenase activity
BWX38_09750	COG1082	Xylose isomerase domain protein TIM barrel
BWX38_09770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BWX38_09775	COG1181	Belongs to the D-alanine--D-alanine ligase family
BWX38_09790	COG1793	dna ligase
BWX38_09790	COG3285	dna ligase
BWX38_09800	COG1192	Involved in chromosome partitioning
BWX38_09815	COG0357	Ribosomal RNA small subunit methyltransferase G
BWX38_09825	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BWX38_09835	COG0594	ribonuclease P activity
BWX38_09845	COG0706	membrane insertase activity
BWX38_09855	COG2076	Multidrug Resistance protein
BWX38_09865	COG0577	efflux transmembrane transporter activity
BWX38_09865	COG1136	(ABC) transporter
BWX38_09870	COG0577	efflux transmembrane transporter activity
BWX38_09870	COG1136	(ABC) transporter
BWX38_09875	COG0592	DNA-directed DNA polymerase activity
BWX38_09885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BWX38_09890	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
BWX38_09900	COG0187	DNA topoisomerase II activity
BWX38_09905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BWX38_09910	COG3266	domain, Protein
BWX38_09920	COG1609	Transcriptional regulator
BWX38_09925	COG1129	ABC transporter
BWX38_09930	COG1172	Belongs to the binding-protein-dependent transport system permease family
BWX38_09935	COG1879	ABC-type sugar transport system periplasmic component
BWX38_09940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BWX38_09945	COG1869	D-ribose catabolic process
BWX38_09970	COG1028	Short-chain dehydrogenase reductase Sdr
BWX38_09985	COG1396	sequence-specific DNA binding
BWX38_09990	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
BWX38_10045	COG1121	(ABC) transporter
BWX38_10055	COG0039	L-malate dehydrogenase activity
BWX38_10070	COG0281	malic enzyme
BWX38_10075	COG0039	L-malate dehydrogenase activity
BWX38_10080	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BWX38_10105	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BWX38_10165	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
BWX38_10175	COG0714	Associated with various cellular activities
BWX38_10235	COG3328	transposase activity
BWX38_10255	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
BWX38_10270	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BWX38_10275	COG4139	cobalamin transport
BWX38_10295	COG0726	polysaccharide deacetylase
BWX38_10305	COG0235	Class ii aldolase
BWX38_10315	COG1063	alcohol dehydrogenase
BWX38_10320	COG3414	Phosphotransferase system galactitol-specific IIB component
BWX38_10325	COG3775	system Galactitol-specific IIC component
BWX38_10335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BWX38_10340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BWX38_10360	COG1131	(ABC) transporter
BWX38_10370	COG0095	Lipoate-protein ligase
BWX38_10380	COG0765	amino acid transport
BWX38_10385	COG1126	abc transporter atp-binding protein
BWX38_10390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BWX38_10405	COG1175	transmembrane transport
BWX38_10415	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BWX38_10435	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BWX38_10500	COG1012	belongs to the aldehyde dehydrogenase family
BWX38_10510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BWX38_10540	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BWX38_10565	COG1136	(ABC) transporter
BWX38_10570	COG2197	response regulator
BWX38_10585	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BWX38_10590	COG3657	addiction module killer protein
BWX38_10595	COG1690	Belongs to the RtcB family
BWX38_10600	COG0477	Major facilitator Superfamily
BWX38_10605	COG1132	(ABC) transporter
BWX38_10630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BWX38_10640	COG2205	protein histidine kinase activity
BWX38_10645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BWX38_10650	COG4585	Histidine kinase
BWX38_10660	COG5002	protein histidine kinase activity
BWX38_10665	COG0745	RESPONSE REGULATOR receiver
BWX38_10675	COG2132	Multicopper oxidase
BWX38_10710	COG0175	sulfate reduction
BWX38_10725	COG0730	response to heat
BWX38_10740	COG1473	amidohydrolase
BWX38_10750	COG0656	L-ascorbic acid biosynthetic process
BWX38_10785	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BWX38_10790	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWX38_10790	COG0596	Alpha beta hydrolase
BWX38_10800	COG2022	thiamine diphosphate biosynthetic process
BWX38_10820	COG1309	transcriptional regulator
BWX38_10825	COG2409	Drug exporters of the RND superfamily
BWX38_10835	COG2801	Transposase and inactivated derivatives
BWX38_10845	COG0438	transferase activity, transferring glycosyl groups
BWX38_10855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BWX38_10860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BWX38_10870	COG2814	Major facilitator Superfamily
BWX38_10880	COG0477	Major facilitator Superfamily
BWX38_10885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BWX38_10890	COG1914	H( )-stimulated, divalent metal cation uptake system
BWX38_10895	COG1321	iron dependent repressor
BWX38_10895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWX38_10910	COG0281	malic enzyme
BWX38_10930	COG1254	Belongs to the acylphosphatase family
BWX38_10935	COG0045	succinate-CoA ligase (ADP-forming) activity
BWX38_10940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BWX38_10950	COG0511	ligase activity, forming carbon-carbon bonds
BWX38_10950	COG5016	pyruvate
BWX38_10960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BWX38_10970	COG1136	(ABC) transporter
BWX38_10970	COG0577	efflux transmembrane transporter activity
BWX38_10995	COG0205	6-phosphofructokinase activity
BWX38_11035	COG3189	MarR family transcriptional regulator
BWX38_11045	COG2217	Heavy metal translocating P-type atpase
BWX38_11055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWX38_11060	COG0783	Belongs to the Dps family
BWX38_11095	COG0456	acetyltransferase
BWX38_11110	COG0435	Glutathione S-transferase
BWX38_11115	COG4166	transmembrane transport
BWX38_11130	COG0601	transmembrane transport
BWX38_11160	COG2337	Toxic component of a toxin-antitoxin (TA) module
BWX38_11170	COG1151	hydroxylamine reductase activity
BWX38_11175	COG0543	2 iron, 2 sulfur cluster binding
BWX38_11175	COG0633	Ferredoxin
BWX38_11180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BWX38_11200	COG1140	nitrate reductase beta subunit
BWX38_11220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BWX38_11230	COG0314	molybdopterin synthase activity
BWX38_11240	COG0315	cyclic pyranopterin monophosphate synthase activity
BWX38_11245	COG0521	Mo-molybdopterin cofactor biosynthetic process
BWX38_11245	COG0315	cyclic pyranopterin monophosphate synthase activity
BWX38_11255	COG0351	phosphomethylpyrimidine kinase
BWX38_11255	COG0352	thiamine-phosphate diphosphorylase activity
BWX38_11255	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BWX38_11260	COG0352	thiamine-phosphate diphosphorylase activity
BWX38_11265	COG3386	PFAM SMP-30 Gluconolaconase
BWX38_11280	COG1172	Belongs to the binding-protein-dependent transport system permease family
BWX38_11285	COG1172	Belongs to the binding-protein-dependent transport system permease family
BWX38_11290	COG1129	ABC transporter
BWX38_11300	COG1609	Transcriptional regulator
BWX38_11330	COG1012	belongs to the aldehyde dehydrogenase family
BWX38_11340	COG1609	Transcriptional regulator
BWX38_11345	COG1904	glucuronate isomerase
BWX38_11350	COG0246	Mannitol dehydrogenase
BWX38_11355	COG1312	Catalyzes the dehydration of D-mannonate
BWX38_11365	COG0656	L-ascorbic acid biosynthetic process
BWX38_11375	COG4948	Mandelate Racemase Muconate Lactonizing
BWX38_11395	COG1285	pathogenesis
BWX38_11405	COG1609	Transcriptional regulator
BWX38_11410	COG0584	glycerophosphoryl diester phosphodiesterase
BWX38_11415	COG1653	transport
BWX38_11420	COG0395	ABC-type sugar transport system, permease component
BWX38_11425	COG1175	transmembrane transport
BWX38_11480	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BWX38_11535	COG1074	ATP-dependent DNA helicase activity
BWX38_11540	COG0210	DNA helicase
BWX38_11575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BWX38_11575	COG0519	Catalyzes the synthesis of GMP from XMP
BWX38_11620	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BWX38_11620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BWX38_11635	COG1070	Carbohydrate kinase
BWX38_11650	COG0641	radical SAM
BWX38_11660	COG2149	membrane
BWX38_11665	COG3119	arylsulfatase activity
BWX38_11670	COG0477	Major facilitator Superfamily
BWX38_11675	COG1940	carbohydrate kinase activity
BWX38_11680	COG3119	arylsulfatase activity
BWX38_11700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BWX38_11710	COG1482	cell wall glycoprotein biosynthetic process
BWX38_11720	COG0800	Aldolase
BWX38_11725	COG1414	Transcriptional regulator
BWX38_11730	COG1609	Transcriptional regulator
BWX38_11740	COG2721	sulfolactate sulfo-lyase activity
BWX38_11745	COG1904	glucuronate isomerase
BWX38_11780	COG2801	Transposase and inactivated derivatives
BWX38_11790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BWX38_11795	COG2826	transposase and inactivated derivatives, IS30 family
BWX38_11835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BWX38_11885	COG2211	Major facilitator Superfamily
BWX38_11915	COG5564	TIM-barrel signal transduction protein
BWX38_11925	COG2186	Transcriptional regulator
BWX38_11940	COG1609	Transcriptional regulator
BWX38_11945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BWX38_11965	COG1228	amidohydrolase
BWX38_11970	COG0402	S-adenosylhomocysteine deaminase activity
BWX38_11975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWX38_11980	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BWX38_11985	COG1414	Transcriptional regulator
BWX38_11990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BWX38_12005	COG1119	ATPase activity
BWX38_12015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWX38_12025	COG0586	Pfam SNARE associated Golgi protein
BWX38_12030	COG1063	alcohol dehydrogenase
BWX38_12045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BWX38_12080	COG1253	flavin adenine dinucleotide binding
BWX38_12110	COG2072	flavoprotein involved in K transport
BWX38_12205	COG3620	sequence-specific DNA binding
BWX38_12225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BWX38_12340	COG2801	Transposase and inactivated derivatives
BWX38_12405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BWX38_12425	COG0438	transferase activity, transferring glycosyl groups
BWX38_12465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BWX38_12495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BWX38_12495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BWX38_12495	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BWX38_12500	COG1105	Belongs to the carbohydrate kinase PfkB family
BWX38_12510	COG0765	amino acid transport
BWX38_12515	COG0765	amino acid transport
BWX38_12520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWX38_12525	COG1126	abc transporter atp-binding protein
BWX38_12530	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BWX38_12545	COG0438	transferase activity, transferring glycosyl groups
BWX38_12560	COG0463	Glycosyl transferase, family 2
BWX38_12605	COG2897	thiosulfate sulfurtransferase activity
BWX38_12620	COG1643	Atp-dependent helicase
BWX38_12635	COG2094	Belongs to the DNA glycosylase MPG family
BWX38_12655	COG1846	Transcriptional regulator
BWX38_12660	COG0386	Belongs to the glutathione peroxidase family
BWX38_12670	COG3118	belongs to the thioredoxin family
BWX38_12675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BWX38_12675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BWX38_12680	COG0305	Participates in initiation and elongation during chromosome replication
BWX38_12685	COG1937	Protein conserved in bacteria
BWX38_12700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BWX38_12710	COG0167	dihydroorotate dehydrogenase activity
BWX38_12715	COG1013	pyruvate-flavodoxin oxidoreductase activity
BWX38_12715	COG0674	pyruvate-flavodoxin oxidoreductase activity
BWX38_12715	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BWX38_12715	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BWX38_12730	COG2186	Transcriptional regulator
BWX38_12735	COG1620	l-lactate permease
BWX38_12740	COG0247	lactate metabolic process
BWX38_12745	COG1139	Iron-sulfur cluster binding protein
BWX38_12750	COG1556	Lactate utilization protein
BWX38_12755	COG1132	(ABC) transporter
BWX38_12760	COG4988	ABC transporter
BWX38_12765	COG1294	oxidase, subunit
BWX38_12770	COG1271	oxidase subunit
BWX38_12780	COG2197	response regulator
BWX38_12810	COG0477	Major facilitator Superfamily
BWX38_12815	COG1454	alcohol dehydrogenase
BWX38_12830	COG0395	ABC-type sugar transport system, permease component
BWX38_12840	COG1609	Transcriptional regulator
BWX38_12855	COG1309	transcriptional regulator
BWX38_12860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BWX38_12885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BWX38_12890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BWX38_12895	COG2186	Transcriptional regulator
BWX38_12915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BWX38_12920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BWX38_12925	COG1301	dicarboxylic acid transport
BWX38_12930	COG1953	Uracil, thiamine, allantoin
BWX38_12940	COG0393	Putative heavy-metal-binding
BWX38_12945	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BWX38_12965	COG0515	serine threonine protein kinase
BWX38_12970	COG0768	penicillin binding
BWX38_12985	COG1716	ATPase activity
BWX38_12990	COG1716	ATPase activity
BWX38_13000	COG1088	dTDP-glucose 4,6-dehydratase activity
BWX38_13005	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BWX38_13025	COG0604	alcohol dehydrogenase
BWX38_13045	COG1316	TRANSCRIPTIONal
BWX38_13055	COG0489	protein tyrosine kinase activity
BWX38_13070	COG0438	transferase activity, transferring glycosyl groups
BWX38_13140	COG0477	Major facilitator Superfamily
BWX38_13145	COG1695	Transcriptional regulator
BWX38_13150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BWX38_13165	COG1113	amino acid transport
BWX38_13170	COG1309	transcriptional regulator
BWX38_13175	COG1131	(ABC) transporter
BWX38_13220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BWX38_13225	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BWX38_13250	COG0577	efflux transmembrane transporter activity
BWX38_13250	COG1136	(ABC) transporter
BWX38_13265	COG0561	phosphatase activity
BWX38_13270	COG0561	phosphatase activity
BWX38_13275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BWX38_13305	COG2801	Transposase and inactivated derivatives
BWX38_13315	COG0861	Integral membrane protein TerC family
BWX38_13320	COG2814	Major facilitator Superfamily
BWX38_13325	COG0583	DNA-binding transcription factor activity
BWX38_13345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BWX38_13350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BWX38_13360	COG0667	Aldo Keto reductase
BWX38_13380	COG1881	PFAM PEBP family protein
BWX38_13390	COG4581	dead DEAH box helicase
BWX38_13400	COG0166	Belongs to the GPI family
BWX38_13415	COG2814	Major facilitator Superfamily
BWX38_13420	COG0656	L-ascorbic acid biosynthetic process
BWX38_13425	COG0018	arginyl-trna synthetase
BWX38_13445	COG2814	Major facilitator Superfamily
BWX38_13460	COG1012	belongs to the aldehyde dehydrogenase family
BWX38_13470	COG1070	Carbohydrate kinase
BWX38_13475	COG4952	isomerase
BWX38_13485	COG3254	rhamnose metabolic process
BWX38_13490	COG1609	Transcriptional regulator
BWX38_13530	COG1609	Transcriptional regulator
BWX38_13545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWX38_13555	COG1027	Aspartate ammonia-lyase
BWX38_13595	COG0477	Major facilitator Superfamily
BWX38_13600	COG1309	transcriptional regulator
BWX38_13610	COG0154	amidase activity
BWX38_13615	COG4608	Belongs to the ABC transporter superfamily
BWX38_13620	COG2814	Major facilitator Superfamily
BWX38_13635	COG1131	(ABC) transporter
BWX38_13640	COG1309	transcriptional regulator
BWX38_13660	COG3830	Belongs to the UPF0237 family
BWX38_13660	COG0560	Phosphoserine phosphatase
BWX38_13665	COG2813	Specifically methylates the guanine in position
BWX38_13670	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BWX38_13675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BWX38_13675	COG0574	Belongs to the PEP-utilizing enzyme family
BWX38_13690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BWX38_13695	COG2205	protein histidine kinase activity
BWX38_13700	COG0745	RESPONSE REGULATOR receiver
BWX38_13720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BWX38_13725	COG0484	heat shock protein binding
BWX38_13730	COG0789	Transcriptional regulator
BWX38_13735	COG1063	alcohol dehydrogenase
BWX38_13740	COG3527	Alpha-acetolactate decarboxylase
BWX38_13745	COG0569	domain protein
BWX38_13745	COG2985	domain, Protein
BWX38_13750	COG1113	amino acid transport
BWX38_13760	COG1136	(ABC) transporter
BWX38_13760	COG0577	efflux transmembrane transporter activity
BWX38_13765	COG0577	efflux transmembrane transporter activity
BWX38_13765	COG1136	(ABC) transporter
BWX38_13775	COG2197	response regulator
BWX38_13780	COG4585	Histidine kinase
BWX38_13805	COG3588	fructose-bisphosphate aldolase
BWX38_13820	COG0395	ABC-type sugar transport system, permease component
BWX38_13830	COG0542	response to heat
BWX38_13835	COG0395	ABC-type sugar transport system, permease component
BWX38_13840	COG1175	transmembrane transport
BWX38_13850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BWX38_13860	COG1486	melibiose metabolic process
BWX38_13875	COG1511	domain protein
BWX38_13890	COG0702	epimerase
BWX38_13910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BWX38_13920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BWX38_13960	COG3012	SEC-C Motif Domain Protein
BWX38_13965	COG0517	IMP dehydrogenase activity
BWX38_13965	COG4175	Glycine betaine
BWX38_13970	COG4176	ABC-type proline glycine betaine transport system permease component
BWX38_13985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BWX38_13990	COG1131	(ABC) transporter
BWX38_14005	COG1174	glycine betaine transport
BWX38_14015	COG1174	glycine betaine transport
BWX38_14030	COG0436	Aminotransferase
BWX38_14050	COG1704	LemA family
BWX38_14055	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BWX38_14055	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BWX38_14075	COG0438	transferase activity, transferring glycosyl groups
BWX38_14085	COG0438	transferase activity, transferring glycosyl groups
BWX38_14095	COG2244	polysaccharide biosynthetic process
BWX38_14100	COG0489	protein tyrosine kinase activity
BWX38_14120	COG0586	Pfam SNARE associated Golgi protein
BWX38_14135	COG0191	fructose-bisphosphate aldolase activity
BWX38_14165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BWX38_14170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BWX38_14175	COG0588	phosphoglycerate mutase activity
BWX38_14180	COG0704	Plays a role in the regulation of phosphate uptake
BWX38_14185	COG5002	protein histidine kinase activity
BWX38_14200	COG1329	Transcriptional regulator
BWX38_14205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BWX38_14215	COG3775	system Galactitol-specific IIC component
BWX38_14225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BWX38_14240	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BWX38_14245	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BWX38_14265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BWX38_14270	COG2814	Major facilitator Superfamily
BWX38_14280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BWX38_14285	COG0215	cysteine-tRNA ligase activity
BWX38_14300	COG0626	cystathionine gamma-synthase activity
BWX38_14360	COG3842	ATPase activity
BWX38_14375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BWX38_14385	COG1760	l-serine dehydratase
BWX38_14390	COG1940	carbohydrate kinase activity
BWX38_14395	COG1653	transport
BWX38_14400	COG1175	transmembrane transport
BWX38_14405	COG0395	ABC-type sugar transport system, permease component
BWX38_14410	COG1063	alcohol dehydrogenase
BWX38_14415	COG0156	8-amino-7-oxononanoate synthase activity
BWX38_14425	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BWX38_14430	COG1131	(ABC) transporter
BWX38_14440	COG4585	Histidine kinase
BWX38_14445	COG2197	response regulator
BWX38_14455	COG0406	alpha-ribazole phosphatase activity
BWX38_14475	COG4585	Histidine kinase
BWX38_14490	COG1492	cobalamin metabolic process
BWX38_14510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BWX38_14510	COG1648	precorrin-2 dehydrogenase activity
BWX38_14525	COG0310	cobalt ion transport
BWX38_14550	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BWX38_14555	COG1797	cobyrinic acid a,c-diamide synthase activity
BWX38_14560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BWX38_14560	COG1648	precorrin-2 dehydrogenase activity
BWX38_14570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BWX38_14600	COG1854	S-ribosylhomocysteine lyase activity
BWX38_14605	COG1482	cell wall glycoprotein biosynthetic process
BWX38_14615	COG0459	protein refolding
BWX38_14660	COG0363	glucosamine-6-phosphate deaminase activity
BWX38_14665	COG1278	Cold shock
BWX38_14680	COG2252	PERMEase
BWX38_14705	COG1321	iron dependent repressor
BWX38_14710	COG2226	methyltransferase
BWX38_14715	COG3118	belongs to the thioredoxin family
BWX38_14720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BWX38_14725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BWX38_14735	COG3718	enzyme involved in inositol metabolism
BWX38_14740	COG3962	Belongs to the TPP enzyme family
BWX38_14755	COG0673	inositol 2-dehydrogenase activity
BWX38_14760	COG2814	Major facilitator Superfamily
BWX38_14765	COG0673	inositol 2-dehydrogenase activity
BWX38_14785	COG1970	mechanosensitive ion channel activity
BWX38_14800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BWX38_14910	COG1196	nuclear chromosome segregation
BWX38_14910	COG0741	lytic transglycosylase activity
BWX38_14910	COG0739	heme binding
BWX38_14990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BWX38_15000	COG2801	Transposase and inactivated derivatives
BWX38_15070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BWX38_15095	COG1053	succinate dehydrogenase
BWX38_15125	COG0789	Transcriptional regulator
BWX38_15135	COG0693	protein deglycase activity
BWX38_15150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BWX38_15195	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BWX38_15205	COG2233	PERMEase
BWX38_15220	COG0084	hydrolase, TatD family'
BWX38_15225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BWX38_15230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BWX38_15235	COG1846	Transcriptional regulator
BWX38_15240	COG1309	transcriptional regulator
BWX38_15250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BWX38_15255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BWX38_15260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BWX38_15265	COG0193	aminoacyl-tRNA hydrolase activity
BWX38_15285	COG0148	phosphopyruvate hydratase activity
BWX38_15315	COG2837	iron assimilation
BWX38_15335	COG1834	amidinotransferase
BWX38_15375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BWX38_15380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BWX38_15385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BWX38_15390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BWX38_15405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BWX38_15410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWX38_15410	COG0072	phenylalanine-tRNA ligase activity
BWX38_15415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BWX38_15430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BWX38_15465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWX38_15470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BWX38_15485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BWX38_15500	COG1331	Highly conserved protein containing a thioredoxin domain
BWX38_15505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BWX38_15515	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BWX38_15525	COG1722	exodeoxyribonuclease VII activity
BWX38_15530	COG1570	exodeoxyribonuclease VII activity
BWX38_15535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BWX38_15540	COG1322	Protein conserved in bacteria
BWX38_15545	COG1362	aminopeptidase activity
BWX38_15565	COG0012	GTP binding
BWX38_15570	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BWX38_15580	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BWX38_15655	COG3549	Plasmid maintenance system killer
BWX38_15675	COG3559	Exporter of polyketide antibiotics
BWX38_15680	COG1131	(ABC) transporter
BWX38_15690	COG3549	Plasmid maintenance system killer
BWX38_15770	COG1397	ADP-ribosylglycohydrolase
BWX38_15785	COG1132	(ABC) transporter
BWX38_15790	COG0406	alpha-ribazole phosphatase activity
BWX38_15810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BWX38_15815	COG1335	isochorismatase
BWX38_15840	COG3321	synthase
BWX38_15840	COG1028	Short-chain dehydrogenase reductase Sdr
BWX38_15840	COG0604	alcohol dehydrogenase
BWX38_15845	COG0477	Major facilitator Superfamily
BWX38_15850	COG0477	Major facilitator Superfamily
BWX38_15875	COG2716	regulation of RNA biosynthetic process
BWX38_15880	COG2133	pyrroloquinoline quinone binding
BWX38_15895	COG0833	amino acid
BWX38_15930	COG2501	S4 domain
BWX38_15950	COG0765	amino acid transport
BWX38_15960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWX38_15980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWX38_15985	COG1121	(ABC) transporter
BWX38_16005	COG1012	belongs to the aldehyde dehydrogenase family
BWX38_16010	COG1063	alcohol dehydrogenase
BWX38_16015	COG2376	Dihydroxyacetone kinase
BWX38_16020	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BWX38_16025	COG1349	DNA-binding transcription factor activity
BWX38_16030	COG0698	ribose 5-phosphate isomerase
BWX38_16040	COG0647	UMP catabolic process
BWX38_16090	COG2814	Major facilitator Superfamily
BWX38_16095	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BWX38_16100	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BWX38_16105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BWX38_16110	COG2720	vancomycin resistance protein
BWX38_16135	COG2171	N-acyltransferase activity
BWX38_16145	COG1611	Belongs to the LOG family
BWX38_16160	COG0297	glycogen (starch) synthase activity
BWX38_16165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BWX38_16195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BWX38_16200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BWX38_16235	COG0006	proline dipeptidase activity
BWX38_16250	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BWX38_16255	COG0531	amino acid
BWX38_16275	COG0598	Magnesium transport protein CorA
BWX38_16300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BWX38_16310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BWX38_16325	COG3093	addiction module antidote protein HigA
BWX38_16335	COG0174	glutamine synthetase
BWX38_16355	COG0586	Pfam SNARE associated Golgi protein
BWX38_16360	COG2239	Acts as a magnesium transporter
BWX38_16365	COG0488	(ABC) transporter
BWX38_16375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BWX38_16390	COG0321	lipoyl(octanoyl) transferase activity
BWX38_16395	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWX38_16435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BWX38_16440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BWX38_16460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BWX38_16465	COG0723	plastoquinol--plastocyanin reductase activity
BWX38_16470	COG2010	Cytochrome c
BWX38_16475	COG1845	cytochrome c oxidase, subunit III
BWX38_16485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BWX38_16530	COG1940	carbohydrate kinase activity
BWX38_16550	COG2197	response regulator
BWX38_16555	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BWX38_16580	COG0352	thiamine-phosphate diphosphorylase activity
BWX38_16590	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BWX38_16595	COG0210	DNA helicase
BWX38_16615	COG1116	anion transmembrane transporter activity
BWX38_16615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BWX38_16620	COG0596	Alpha beta hydrolase
BWX38_16630	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BWX38_16640	COG3265	gluconokinase activity
BWX38_16660	COG1131	(ABC) transporter
BWX38_16665	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BWX38_16665	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BWX38_16670	COG0509	glycine decarboxylation via glycine cleavage system