locus-tag	class	description
C0Z10_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C0Z10_00010	COG1136	(ABC) transporter
C0Z10_00010	COG0577	efflux transmembrane transporter activity
C0Z10_00015	COG0577	efflux transmembrane transporter activity
C0Z10_00020	COG0592	DNA-directed DNA polymerase activity
C0Z10_00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0Z10_00035	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C0Z10_00040	COG1482	cell wall glycoprotein biosynthetic process
C0Z10_00045	COG3250	beta-galactosidase activity
C0Z10_00055	COG0187	DNA topoisomerase II activity
C0Z10_00060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C0Z10_00065	COG3266	domain, Protein
C0Z10_00070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0Z10_00070	COG3711	transcriptional antiterminator
C0Z10_00080	COG2213	PTS system mannitol-specific
C0Z10_00085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0Z10_00090	COG0246	Mannitol dehydrogenase
C0Z10_00095	COG0673	inositol 2-dehydrogenase activity
C0Z10_00100	COG0039	L-malate dehydrogenase activity
C0Z10_00170	COG0039	L-malate dehydrogenase activity
C0Z10_00190	COG0039	L-malate dehydrogenase activity
C0Z10_00245	COG2272	Belongs to the type-B carboxylesterase lipase family
C0Z10_00250	COG0436	Aminotransferase
C0Z10_00255	COG1942	4-Oxalocrotonate Tautomerase
C0Z10_00260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C0Z10_00270	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0Z10_00275	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0Z10_00275	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0Z10_00280	COG3715	PTS system
C0Z10_00285	COG3716	PTS system mannose fructose sorbose family IID component
C0Z10_00310	COG1131	(ABC) transporter
C0Z10_00320	COG0095	Lipoate-protein ligase
C0Z10_00325	COG0765	amino acid transport
C0Z10_00330	COG1126	abc transporter atp-binding protein
C0Z10_00335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0Z10_00365	COG0310	cobalt ion transport
C0Z10_00370	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
C0Z10_00375	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C0Z10_00390	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C0Z10_00395	COG1797	cobyrinic acid a,c-diamide synthase activity
C0Z10_00400	COG1648	precorrin-2 dehydrogenase activity
C0Z10_00400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0Z10_00410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C0Z10_00445	COG1854	S-ribosylhomocysteine lyase activity
C0Z10_00485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0Z10_00500	COG0459	protein refolding
C0Z10_00505	COG0540	Belongs to the ATCase OTCase family
C0Z10_00520	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C0Z10_00525	COG0114	fumarate hydratase activity
C0Z10_00590	COG1012	belongs to the aldehyde dehydrogenase family
C0Z10_00595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C0Z10_00605	COG3588	fructose-bisphosphate aldolase
C0Z10_00610	COG2197	response regulator
C0Z10_00615	COG4585	Histidine kinase
C0Z10_00625	COG1131	(ABC) transporter
C0Z10_00630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C0Z10_00655	COG0577	efflux transmembrane transporter activity
C0Z10_00655	COG1136	(ABC) transporter
C0Z10_00660	COG2197	response regulator
C0Z10_00665	COG4585	Histidine kinase
C0Z10_00675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0Z10_00680	COG1309	transcriptional regulator
C0Z10_00685	COG2409	Drug exporters of the RND superfamily
C0Z10_00695	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0Z10_00700	COG0281	malic enzyme
C0Z10_00725	COG1254	Belongs to the acylphosphatase family
C0Z10_00735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0Z10_00735	COG1042	CoA-binding domain protein
C0Z10_00735	COG0045	succinate-CoA ligase (ADP-forming) activity
C0Z10_00740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0Z10_00750	COG1136	(ABC) transporter
C0Z10_00760	COG0205	6-phosphofructokinase activity
C0Z10_00790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0Z10_00830	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C0Z10_00840	COG2205	protein histidine kinase activity
C0Z10_00860	COG1132	(ABC) transporter
C0Z10_00865	COG1132	(ABC) transporter
C0Z10_00885	COG0395	ABC-type sugar transport system, permease component
C0Z10_00890	COG0366	Alpha amylase catalytic
C0Z10_00900	COG1285	pathogenesis
C0Z10_00905	COG1501	Belongs to the glycosyl hydrolase 31 family
C0Z10_00930	COG2318	DinB family
C0Z10_00965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0Z10_00970	COG0765	amino acid transport
C0Z10_00975	COG0765	amino acid transport
C0Z10_00980	COG1126	abc transporter atp-binding protein
C0Z10_00995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C0Z10_01005	COG0006	proline dipeptidase activity
C0Z10_01010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0Z10_01015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0Z10_01035	COG0022	dehydrogenase e1 component
C0Z10_01040	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0Z10_01050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0Z10_01060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C0Z10_01070	COG0077	Prephenate dehydratase
C0Z10_01075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0Z10_01090	COG0561	phosphatase activity
C0Z10_01100	COG0137	argininosuccinate synthase activity
C0Z10_01115	COG0604	alcohol dehydrogenase
C0Z10_01120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C0Z10_01125	COG1609	Transcriptional regulator
C0Z10_01130	COG1316	TRANSCRIPTIONal
C0Z10_01150	COG0584	glycerophosphoryl diester phosphodiesterase
C0Z10_01155	COG0823	Involved in the tonB-independent uptake of proteins
C0Z10_01155	COG4946	Tricorn protease homolog
C0Z10_01155	COG1506	peptidase
C0Z10_01175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C0Z10_01185	COG0590	tRNA wobble adenosine to inosine editing
C0Z10_01220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C0Z10_01230	COG1174	glycine betaine transport
C0Z10_01245	COG3263	regulation of cellular component size
C0Z10_01260	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C0Z10_01270	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C0Z10_01275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0Z10_01280	COG1609	Transcriptional regulator
C0Z10_01285	COG1129	ABC transporter
C0Z10_01290	COG1172	Belongs to the binding-protein-dependent transport system permease family
C0Z10_01295	COG1879	ABC-type sugar transport system periplasmic component
C0Z10_01300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0Z10_01305	COG1869	D-ribose catabolic process
C0Z10_01310	COG0673	inositol 2-dehydrogenase activity
C0Z10_01315	COG4974	Belongs to the 'phage' integrase family
C0Z10_01320	COG0582	viral genome integration into host DNA
C0Z10_01325	COG4974	Belongs to the 'phage' integrase family
C0Z10_01370	COG0395	ABC-type sugar transport system, permease component
C0Z10_01375	COG1175	transmembrane transport
C0Z10_01380	COG1653	transport
C0Z10_01385	COG2222	sugar isomerase
C0Z10_01395	COG0586	Pfam SNARE associated Golgi protein
C0Z10_01435	COG1518	maintenance of DNA repeat elements
C0Z10_01435	COG1468	defense response to virus
C0Z10_01470	COG2801	Transposase and inactivated derivatives
C0Z10_01470	COG3415	Transposase
C0Z10_01475	COG2807	transmembrane transport
C0Z10_01520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0Z10_01525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0Z10_01530	COG1072	(Pantothenic acid kinase))
C0Z10_01535	COG0519	Catalyzes the synthesis of GMP from XMP
C0Z10_01550	COG3022	response to hydroperoxide
C0Z10_01560	COG4608	Belongs to the ABC transporter superfamily
C0Z10_01565	COG0444	Belongs to the ABC transporter superfamily
C0Z10_01570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0Z10_01590	COG1846	Transcriptional regulator
C0Z10_01600	COG1408	metallophosphoesterase
C0Z10_01605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0Z10_01620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0Z10_01630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0Z10_01685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0Z10_01690	COG1111	helicase
C0Z10_01690	COG1205	dead DEAH box helicase
C0Z10_01705	COG1754	DNA topoisomerase type I activity
C0Z10_01705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C0Z10_01715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C0Z10_01720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C0Z10_01730	COG1774	PSP1 C-terminal conserved region
C0Z10_01735	COG0596	Alpha beta hydrolase
C0Z10_01780	COG1063	alcohol dehydrogenase
C0Z10_01790	COG1231	oxidoreductase activity
C0Z10_01795	COG0431	NADPH-dependent FMN reductase
C0Z10_01805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0Z10_01805	COG0519	Catalyzes the synthesis of GMP from XMP
C0Z10_01825	COG0601	transmembrane transport
C0Z10_01830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0Z10_01890	COG3458	cephalosporin-C deacetylase activity
C0Z10_01900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C0Z10_01910	COG0037	tRNA processing
C0Z10_01925	COG0302	gtp cyclohydrolase
C0Z10_01935	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C0Z10_01960	COG0542	response to heat
C0Z10_01990	COG2409	Drug exporters of the RND superfamily
C0Z10_02020	COG3842	ATPase activity
C0Z10_02030	COG2271	Major facilitator Superfamily
C0Z10_02035	COG0445	tRNA wobble uridine modification
C0Z10_02040	COG1609	Transcriptional regulator
C0Z10_02055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0Z10_02060	COG0113	porphobilinogen synthase activity
C0Z10_02070	COG0181	hydroxymethylbilane synthase activity
C0Z10_02080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C0Z10_02085	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C0Z10_02100	COG3655	Transcriptional regulator
C0Z10_02110	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C0Z10_02115	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C0Z10_02125	COG1082	Xylose isomerase domain protein TIM barrel
C0Z10_02130	COG0506	proline dehydrogenase activity
C0Z10_02145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0Z10_02160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0Z10_02165	COG0406	alpha-ribazole phosphatase activity
C0Z10_02170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0Z10_02175	COG0785	Cytochrome C biogenesis protein
C0Z10_02185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0Z10_02195	COG4221	oxidoreductase activity
C0Z10_02205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0Z10_02230	COG1120	ATPase activity
C0Z10_02235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0Z10_02240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0Z10_02245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0Z10_02250	COG1132	(ABC) transporter
C0Z10_02255	COG1132	(ABC) transporter
C0Z10_02265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C0Z10_02270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0Z10_02275	COG0254	rRNA binding
C0Z10_02280	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C0Z10_02285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C0Z10_02300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C0Z10_02310	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C0Z10_02315	COG0745	RESPONSE REGULATOR receiver
C0Z10_02335	COG1490	D-aminoacyl-tRNA deacylase activity
C0Z10_02345	COG3485	protocatechuate 3,4-dioxygenase
C0Z10_02355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0Z10_02380	COG2814	Major facilitator Superfamily
C0Z10_02395	COG1937	Protein conserved in bacteria
C0Z10_02410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C0Z10_02415	COG0697	spore germination
C0Z10_02425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C0Z10_02430	COG0583	DNA-binding transcription factor activity
C0Z10_02440	COG0450	alkyl hydroperoxide reductase
C0Z10_02445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C0Z10_02450	COG0047	phosphoribosylformylglycinamidine synthase activity
C0Z10_02455	COG1113	amino acid transport
C0Z10_02460	COG0252	asparaginase activity
C0Z10_02480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0Z10_02500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0Z10_02510	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C0Z10_02515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C0Z10_02540	COG0395	ABC-type sugar transport system, permease component
C0Z10_02605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C0Z10_02610	COG4133	protoheme IX ABC transporter activity
C0Z10_02645	COG1834	amidinotransferase
C0Z10_02650	COG0531	amino acid
C0Z10_02670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C0Z10_02690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0Z10_02690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0Z10_02690	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C0Z10_02695	COG1461	Dihydroxyacetone kinase
C0Z10_02700	COG2376	Dihydroxyacetone kinase
C0Z10_02705	COG2814	Major facilitator Superfamily
C0Z10_02715	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C0Z10_02720	COG1132	(ABC) transporter
C0Z10_02730	COG2226	methyltransferase
C0Z10_02760	COG0644	oxidoreductase
C0Z10_02770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0Z10_02775	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0Z10_02780	COG0649	NAD binding
C0Z10_02790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C0Z10_02795	COG1034	ATP synthesis coupled electron transport
C0Z10_02800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C0Z10_02805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0Z10_02815	COG0713	ATP synthesis coupled electron transport
C0Z10_02830	COG1007	ATP synthesis coupled electron transport
C0Z10_02850	COG2301	Belongs to the HpcH HpaI aldolase family
C0Z10_02855	COG3590	peptidase
C0Z10_02865	COG1013	pyruvate-flavodoxin oxidoreductase activity
C0Z10_02870	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C0Z10_02870	COG0674	pyruvate-flavodoxin oxidoreductase activity
C0Z10_02880	COG1024	Enoyl-CoA hydratase
C0Z10_02885	COG0708	Exodeoxyribonuclease III
C0Z10_02895	COG1666	GTP binding
C0Z10_02915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0Z10_02920	COG2030	dehydratase
C0Z10_02930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C0Z10_02935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0Z10_02950	COG0250	Participates in transcription elongation, termination and antitermination
C0Z10_02955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0Z10_02960	COG0081	regulation of translation
C0Z10_02965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C0Z10_02970	COG0222	ribosome binding
C0Z10_02975	COG0085	RNA polymerase activity
C0Z10_02980	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0Z10_02985	COG0673	inositol 2-dehydrogenase activity
C0Z10_02990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C0Z10_02995	COG0049	tRNA binding
C0Z10_03000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C0Z10_03005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0Z10_03020	COG0737	Belongs to the 5'-nucleotidase family
C0Z10_03025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0Z10_03030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0Z10_03035	COG0051	transcription antitermination factor activity, RNA binding
C0Z10_03040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C0Z10_03045	COG0088	Forms part of the polypeptide exit tunnel
C0Z10_03050	COG0089	rRNA binding
C0Z10_03055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C0Z10_03060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C0Z10_03065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C0Z10_03070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C0Z10_03075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C0Z10_03080	COG0255	Belongs to the universal ribosomal protein uL29 family
C0Z10_03085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C0Z10_03100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C0Z10_03105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C0Z10_03110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C0Z10_03115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C0Z10_03120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C0Z10_03125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C0Z10_03130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C0Z10_03135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C0Z10_03140	COG1841	ribosomal large subunit assembly
C0Z10_03145	COG0200	Binds to the 23S rRNA
C0Z10_03180	COG0563	adenylate kinase activity
C0Z10_03200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C0Z10_03205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C0Z10_03215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C0Z10_03220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C0Z10_03225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0Z10_03230	COG0202	RNA polymerase activity
C0Z10_03235	COG0203	ribosomal protein L17
C0Z10_03240	COG0438	transferase activity, transferring glycosyl groups
C0Z10_03285	COG0101	tRNA pseudouridine synthase activity
C0Z10_03290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C0Z10_03295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C0Z10_03300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0Z10_03305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0Z10_03315	COG1072	(Pantothenic acid kinase))
C0Z10_03320	COG2264	protein methyltransferase activity
C0Z10_03325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0Z10_03330	COG0736	holo-[acyl-carrier-protein] synthase activity
C0Z10_03335	COG1940	carbohydrate kinase activity
C0Z10_03335	COG1846	Transcriptional regulator
C0Z10_03345	COG0395	ABC-type sugar transport system, permease component
C0Z10_03350	COG1175	transmembrane transport
C0Z10_03360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C0Z10_03360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C0Z10_03365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0Z10_03365	COG0438	transferase activity, transferring glycosyl groups
C0Z10_03370	COG0513	Belongs to the DEAD box helicase family
C0Z10_03375	COG0802	atpase or kinase
C0Z10_03380	COG0456	acetyltransferase
C0Z10_03380	COG1214	PFAM Peptidase M22, glycoprotease
C0Z10_03385	COG0456	acetyltransferase
C0Z10_03390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C0Z10_03435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C0Z10_03440	COG0459	protein refolding
C0Z10_03455	COG0516	GMP reductase activity
C0Z10_03465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C0Z10_03470	COG0287	Prephenate dehydrogenase
C0Z10_03470	COG1605	Chorismate mutase
C0Z10_03475	COG1045	serine acetyltransferase
C0Z10_03480	COG0519	Catalyzes the synthesis of GMP from XMP
C0Z10_03480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0Z10_03505	COG2197	response regulator
C0Z10_03510	COG2261	transglycosylase associated protein
C0Z10_03515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0Z10_03520	COG2011	ABC-type metal ion transport system permease component
C0Z10_03525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0Z10_03530	COG1464	Belongs to the NlpA lipoprotein family
C0Z10_03545	COG0045	succinate-CoA ligase (ADP-forming) activity
C0Z10_03575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0Z10_03575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0Z10_03580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C0Z10_03590	COG0138	bifunctional purine biosynthesis protein purh
C0Z10_03605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0Z10_03615	COG0039	L-malate dehydrogenase activity
C0Z10_03630	COG1253	flavin adenine dinucleotide binding
C0Z10_03640	COG1744	ABC transporter substrate-binding protein PnrA-like
C0Z10_03670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0Z10_03685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0Z10_03700	COG4770	biotin carboxylase activity
C0Z10_03710	COG0351	phosphomethylpyrimidine kinase
C0Z10_03715	COG4221	oxidoreductase activity
C0Z10_03720	COG2235	arginine
C0Z10_03730	COG0424	maF-like protein
C0Z10_03740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0Z10_03745	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C0Z10_03745	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C0Z10_03750	COG3340	Belongs to the peptidase S51 family
C0Z10_03770	COG1316	TRANSCRIPTIONal
C0Z10_03830	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C0Z10_03835	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C0Z10_03865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C0Z10_03880	COG1918	ferrous iron import across plasma membrane
C0Z10_03880	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C0Z10_03890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C0Z10_03895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C0Z10_03900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C0Z10_03905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C0Z10_03910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C0Z10_03915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0Z10_03935	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C0Z10_03970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C0Z10_03985	COG0587	DNA-directed DNA polymerase activity
C0Z10_04005	COG0531	amino acid
C0Z10_04010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0Z10_04025	COG1113	amino acid transport
C0Z10_04030	COG1321	iron dependent repressor
C0Z10_04030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0Z10_04035	COG1914	H( )-stimulated, divalent metal cation uptake system
C0Z10_04045	COG0604	alcohol dehydrogenase
C0Z10_04080	COG1305	Transglutaminase-like
C0Z10_04135	COG1051	belongs to the nudix hydrolase family
C0Z10_04150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0Z10_04180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C0Z10_04215	COG2235	arginine
C0Z10_04245	COG0277	FAD linked oxidase domain protein
C0Z10_04245	COG0247	lactate metabolic process
C0Z10_04260	COG1022	Amp-dependent synthetase and ligase
C0Z10_04275	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C0Z10_04290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0Z10_04295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0Z10_04310	COG0698	ribose 5-phosphate isomerase
C0Z10_04330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C0Z10_04330	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C0Z10_04350	COG0544	peptidyl-prolyl cis-trans isomerase activity
C0Z10_04360	COG0740	serine-type endopeptidase activity
C0Z10_04365	COG0740	serine-type endopeptidase activity
C0Z10_04370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C0Z10_04375	COG0793	Belongs to the peptidase S41A family
C0Z10_04375	COG4946	Tricorn protease homolog
C0Z10_04395	COG0525	valine-tRNA ligase activity
C0Z10_04405	COG0363	glucosamine-6-phosphate deaminase activity
C0Z10_04420	COG0109	protoheme IX farnesyltransferase activity
C0Z10_04430	COG1612	heme a metabolic process
C0Z10_04445	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C0Z10_04450	COG1609	Transcriptional regulator
C0Z10_04455	COG3833	ABC-type maltose transport systems, permease component
C0Z10_04460	COG1175	transmembrane transport
C0Z10_04475	COG0719	Fe-S assembly protein
C0Z10_04490	COG0396	ATPase activity
C0Z10_04495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C0Z10_04525	COG0488	(ABC) transporter
C0Z10_04535	COG2226	methyltransferase
C0Z10_04570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C0Z10_04575	COG1119	ATPase activity
C0Z10_04600	COG0242	peptide deformylase activity
C0Z10_04610	COG4974	Belongs to the 'phage' integrase family
C0Z10_04615	COG0739	heme binding
C0Z10_04615	COG1196	nuclear chromosome segregation
C0Z10_04615	COG0741	lytic transglycosylase activity
C0Z10_04620	COG0052	Belongs to the universal ribosomal protein uS2 family
C0Z10_04625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C0Z10_04630	COG0528	UMP kinase activity
C0Z10_04635	COG0233	cytoplasmic translational termination
C0Z10_04640	COG0575	Belongs to the CDS family
C0Z10_04645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0Z10_04650	COG0387	Pfam Sodium calcium exchanger
C0Z10_04655	COG0750	zinc metalloprotease
C0Z10_04660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C0Z10_04680	COG1305	Transglutaminase-like
C0Z10_04685	COG0442	prolyl-tRNA aminoacylation
C0Z10_04700	COG0779	Required for maturation of 30S ribosomal subunits
C0Z10_04715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C0Z10_04720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C0Z10_04725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C0Z10_04730	COG0196	riboflavin kinase activity
C0Z10_04735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C0Z10_04755	COG1185	polyribonucleotide nucleotidyltransferase activity
C0Z10_04775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C0Z10_04785	COG0028	Belongs to the TPP enzyme family
C0Z10_04795	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C0Z10_04800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C0Z10_04805	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C0Z10_04815	COG0742	ribosomal rna small subunit methyltransferase
C0Z10_04820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C0Z10_04830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C0Z10_04835	COG0571	ribonuclease III activity
C0Z10_04840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0Z10_04865	COG2076	Multidrug Resistance protein
C0Z10_04895	COG0228	four-way junction DNA binding
C0Z10_04900	COG1837	Belongs to the UPF0109 family
C0Z10_04905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0Z10_04910	COG0336	Belongs to the RNA methyltransferase TrmD family
C0Z10_04920	COG1053	succinate dehydrogenase
C0Z10_04925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0Z10_04935	COG0335	large ribosomal subunit rRNA binding
C0Z10_04940	COG0681	Belongs to the peptidase S26 family
C0Z10_04945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0Z10_04955	COG0792	nuclease activity
C0Z10_04960	COG0606	chelatase, subunit chli
C0Z10_05005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0Z10_05015	COG0667	Aldo Keto reductase
C0Z10_05025	COG3201	nicotinamide mononucleotide transporter
C0Z10_05030	COG0140	phosphoribosyl-ATP diphosphatase activity
C0Z10_05035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C0Z10_05070	COG0647	UMP catabolic process
C0Z10_05075	COG1268	BioY protein
C0Z10_05080	COG1122	ATPase activity
C0Z10_05090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C0Z10_05095	COG0497	DNA recombination
C0Z10_05100	COG0504	CTP synthase activity
C0Z10_05105	COG0494	nUDIX hydrolase
C0Z10_05110	COG4974	Belongs to the 'phage' integrase family
C0Z10_05135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0Z10_05145	COG2378	regulation of single-species biofilm formation
C0Z10_05170	COG4581	dead DEAH box helicase
C0Z10_05175	COG0107	imidazoleglycerol-phosphate synthase activity
C0Z10_05180	COG0537	adenosine 5'-monophosphoramidase activity
C0Z10_05195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C0Z10_05205	COG0473	3-isopropylmalate dehydrogenase activity
C0Z10_05210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0Z10_05215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0Z10_05225	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0Z10_05230	COG1266	CAAX protease self-immunity
C0Z10_05245	COG1414	Transcriptional regulator
C0Z10_05250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C0Z10_05255	COG0066	3-isopropylmalate dehydratase activity
C0Z10_05265	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0Z10_05285	COG1674	ftsk spoiiie
C0Z10_05305	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C0Z10_05310	COG2884	Cell division ATP-binding protein ftsE
C0Z10_05320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C0Z10_05325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C0Z10_05330	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C0Z10_05335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0Z10_05340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0Z10_05350	COG0165	Argininosuccinate lyase
C0Z10_05380	COG1678	Uncharacterized ACR, COG1678
C0Z10_05385	COG0745	RESPONSE REGULATOR receiver
C0Z10_05390	COG5000	phosphorelay sensor kinase activity
C0Z10_05390	COG5002	protein histidine kinase activity
C0Z10_05395	COG5401	PFAM Sporulation and spore germination
C0Z10_05405	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C0Z10_05415	COG0653	protein targeting
C0Z10_05435	COG2902	Dehydrogenase
C0Z10_05445	COG0180	Tryptophanyl-tRNA synthetase
C0Z10_05480	COG1074	ATP-dependent DNA helicase activity
C0Z10_05505	COG1074	ATP-dependent DNA helicase activity
C0Z10_05530	COG3480	Lon protease (S16) C-terminal proteolytic domain
C0Z10_05540	COG1615	UPF0182 protein
C0Z10_05585	COG4608	Belongs to the ABC transporter superfamily
C0Z10_05590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0Z10_05595	COG0483	inositol monophosphate 1-phosphatase activity
C0Z10_05610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0Z10_05620	COG1595	DNA-templated transcription, initiation
C0Z10_05645	COG0567	Dehydrogenase, E1 component
C0Z10_05645	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0Z10_05655	COG1611	Belongs to the LOG family
C0Z10_05665	COG0019	diaminopimelate decarboxylase activity
C0Z10_05670	COG0460	homoserine dehydrogenase
C0Z10_05675	COG0083	homoserine kinase activity
C0Z10_05685	COG0254	rRNA binding
C0Z10_05690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0Z10_05695	COG2890	protein-(glutamine-N5) methyltransferase activity
C0Z10_05705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0Z10_05715	COG2244	polysaccharide biosynthetic process
C0Z10_05775	COG0318	PFAM AMP-dependent synthetase and ligase
C0Z10_05785	COG0736	holo-[acyl-carrier-protein] synthase activity
C0Z10_05790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C0Z10_05795	COG0367	asparagine synthase
C0Z10_05800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0Z10_05805	COG1045	serine acetyltransferase
C0Z10_05820	COG0356	it plays a direct role in the translocation of protons across the membrane
C0Z10_05830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C0Z10_05835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0Z10_05840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C0Z10_05845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C0Z10_05850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C0Z10_05855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C0Z10_05870	COG0596	Alpha beta hydrolase
C0Z10_05915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C0Z10_05930	COG1560	Kdo2-lipid A biosynthetic process
C0Z10_05935	COG0438	transferase activity, transferring glycosyl groups
C0Z10_05955	COG0509	glycine decarboxylation via glycine cleavage system
C0Z10_05960	COG1716	ATPase activity
C0Z10_05980	COG1295	ribonuclease BN
C0Z10_05985	COG0205	6-phosphofructokinase activity
C0Z10_05995	COG0009	L-threonylcarbamoyladenylate synthase
C0Z10_06000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C0Z10_06005	COG1597	lipid kinase activity
C0Z10_06010	COG1472	Belongs to the glycosyl hydrolase 3 family
C0Z10_06015	COG1739	Uncharacterized protein family UPF0029
C0Z10_06025	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C0Z10_06060	COG0531	amino acid
C0Z10_06075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0Z10_06080	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C0Z10_06085	COG0584	glycerophosphoryl diester phosphodiesterase
C0Z10_06095	COG1216	Glycosyl transferase, family 2
C0Z10_06100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C0Z10_06105	COG1522	sequence-specific DNA binding
C0Z10_06110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0Z10_06115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0Z10_06120	COG0427	acetyl-CoA hydrolase
C0Z10_06130	COG0561	phosphatase activity
C0Z10_06240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0Z10_06250	COG0028	Belongs to the TPP enzyme family
C0Z10_06285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0Z10_06290	COG0384	phenazine biosynthesis protein PhzF
C0Z10_06335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C0Z10_06400	COG0477	Major facilitator Superfamily
C0Z10_06415	COG3850	Histidine kinase
C0Z10_06420	COG2409	Drug exporters of the RND superfamily
C0Z10_06440	COG1764	response to oxidative stress
C0Z10_06455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C0Z10_06465	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C0Z10_06470	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C0Z10_06485	COG0646	methionine synthase
C0Z10_06485	COG1410	methionine synthase
C0Z10_06495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C0Z10_06505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0Z10_06525	COG1201	RNA secondary structure unwinding
C0Z10_06530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C0Z10_06540	COG1758	RNA polymerase activity
C0Z10_06545	COG0194	GDP metabolic process
C0Z10_06555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0Z10_06560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C0Z10_06570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C0Z10_06580	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C0Z10_06585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C0Z10_06590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0Z10_06595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C0Z10_06600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0Z10_06630	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C0Z10_06640	COG1309	transcriptional regulator
C0Z10_06660	COG5433	transposase activity
C0Z10_06670	COG0124	histidyl-tRNA synthetase
C0Z10_06680	COG1196	nuclear chromosome segregation
C0Z10_06685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C0Z10_06690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0Z10_06700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0Z10_06705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0Z10_06710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0Z10_06720	COG2255	four-way junction helicase activity
C0Z10_06725	COG0632	four-way junction helicase activity
C0Z10_06730	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C0Z10_06735	COG0217	transcriptional regulatory protein
C0Z10_06740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C0Z10_06745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0Z10_06750	COG0131	Imidazoleglycerol-phosphate dehydratase
C0Z10_06755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0Z10_06760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C0Z10_06790	COG0069	glutamate synthase activity
C0Z10_06790	COG0067	glutamate synthase
C0Z10_06790	COG0070	glutamate synthase
C0Z10_06795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C0Z10_06800	COG0159	tryptophan synthase activity
C0Z10_06805	COG0133	tryptophan synthase activity
C0Z10_06810	COG0134	indole-3-glycerol-phosphate synthase activity
C0Z10_06825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C0Z10_06830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0Z10_06845	COG2233	PERMEase
C0Z10_06850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0Z10_06855	COG0154	amidase activity
C0Z10_06860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0Z10_06875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0Z10_06885	COG1116	anion transmembrane transporter activity
C0Z10_06900	COG0482	sulfurtransferase activity
C0Z10_06920	COG0366	Alpha amylase catalytic
C0Z10_06925	COG3281	Trehalose synthase
C0Z10_06930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C0Z10_06955	COG0033	Phosphoglucomutase
C0Z10_06990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0Z10_07005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0Z10_07010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C0Z10_07015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0Z10_07020	COG0531	amino acid
C0Z10_07025	COG0569	domain protein
C0Z10_07045	COG0756	dUTP diphosphatase activity
C0Z10_07080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C0Z10_07100	COG0187	DNA topoisomerase II activity
C0Z10_07120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0Z10_07130	COG1946	Acyl-CoA thioesterase
C0Z10_07135	COG5426	von Willebrand factor, type A
C0Z10_07140	COG1643	Atp-dependent helicase
C0Z10_07160	COG0717	Belongs to the dCTP deaminase family
C0Z10_07165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0Z10_07170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0Z10_07185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0Z10_07190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C0Z10_07195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C0Z10_07205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0Z10_07210	COG2017	converts alpha-aldose to the beta-anomer
C0Z10_07215	COG1418	mRNA catabolic process
C0Z10_07220	COG2137	regulation of response to DNA damage stimulus
C0Z10_07235	COG1349	DNA-binding transcription factor activity
C0Z10_07245	COG1546	Belongs to the CinA family
C0Z10_07245	COG1058	Belongs to the CinA family
C0Z10_07255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0Z10_07265	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C0Z10_07270	COG0284	orotidine-5'-phosphate decarboxylase activity
C0Z10_07275	COG0167	dihydroorotate dehydrogenase activity
C0Z10_07280	COG0543	2 iron, 2 sulfur cluster binding
C0Z10_07285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0Z10_07300	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C0Z10_07310	COG0667	Aldo Keto reductase
C0Z10_07320	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C0Z10_07335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C0Z10_07345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0Z10_07350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0Z10_07375	COG2304	oxidoreductase activity
C0Z10_07385	COG0714	Associated with various cellular activities
C0Z10_07415	COG0515	serine threonine protein kinase
C0Z10_07420	COG2818	Glycosylase
C0Z10_07425	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C0Z10_07430	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C0Z10_07435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0Z10_07450	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C0Z10_07455	COG0488	(ABC) transporter
C0Z10_07460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0Z10_07480	COG0358	DNA primase activity
C0Z10_07485	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C0Z10_07505	COG1053	succinate dehydrogenase
C0Z10_07520	COG1051	belongs to the nudix hydrolase family
C0Z10_07525	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C0Z10_07530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C0Z10_07540	COG0423	glycine-tRNA ligase activity
C0Z10_07545	COG0735	belongs to the Fur family
C0Z10_07560	COG0798	PFAM Bile acid sodium symporter
C0Z10_07565	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0Z10_07600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0Z10_07625	COG5433	transposase activity
C0Z10_07660	COG3421	Type III restriction
C0Z10_07665	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C0Z10_07685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0Z10_07720	COG1381	Involved in DNA repair and RecF pathway recombination
C0Z10_07725	COG1404	Belongs to the peptidase S8 family
C0Z10_07730	COG0475	glutathione-regulated potassium exporter activity
C0Z10_07730	COG0569	domain protein
C0Z10_07735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0Z10_07745	COG0765	amino acid transport
C0Z10_07750	COG0765	amino acid transport
C0Z10_07755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0Z10_07760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0Z10_07770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C0Z10_07780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C0Z10_07805	COG1668	transmembrane transport
C0Z10_07810	COG4152	abc transporter atp-binding protein
C0Z10_07815	COG2197	response regulator
C0Z10_07820	COG4585	Histidine kinase
C0Z10_07825	COG0343	queuine tRNA-ribosyltransferase activity
C0Z10_07835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0Z10_07845	COG2259	Doxx family
C0Z10_07855	COG0484	heat shock protein binding
C0Z10_07860	COG1420	regulation of RNA biosynthetic process
C0Z10_07880	COG0483	inositol monophosphate 1-phosphatase activity
C0Z10_07900	COG1175	transmembrane transport
C0Z10_07905	COG0395	ABC-type sugar transport system, permease component
C0Z10_07915	COG1309	transcriptional regulator
C0Z10_07920	COG1131	(ABC) transporter
C0Z10_07930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0Z10_07935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0Z10_07945	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C0Z10_07965	COG1169	isochorismate synthase
C0Z10_07970	COG0488	(ABC) transporter
C0Z10_07975	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C0Z10_07980	COG4948	Mandelate Racemase Muconate Lactonizing
C0Z10_07985	COG0481	GTPase activity
C0Z10_07990	COG0268	Binds directly to 16S ribosomal RNA
C0Z10_08000	COG1061	Type III restriction enzyme res subunit
C0Z10_08015	COG0495	leucyl-tRNA aminoacylation
C0Z10_08030	COG0366	Alpha amylase catalytic
C0Z10_08035	COG2217	Heavy metal translocating P-type atpase
C0Z10_08045	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C0Z10_08050	COG0352	thiamine-phosphate diphosphorylase activity
C0Z10_08125	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C0Z10_08150	COG3451	type IV secretory pathway VirB4
C0Z10_08205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C0Z10_08210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C0Z10_08215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C0Z10_08220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C0Z10_08230	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C0Z10_08235	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C0Z10_08240	COG1530	ribonuclease E activity
C0Z10_08245	COG1472	Belongs to the glycosyl hydrolase 3 family
C0Z10_08250	COG0105	UTP biosynthetic process
C0Z10_08260	COG0285	dihydrofolate synthase activity
C0Z10_08270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0Z10_08275	COG0149	triose-phosphate isomerase activity
C0Z10_08280	COG0126	phosphoglycerate kinase activity
C0Z10_08285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0Z10_08290	COG1481	regulation of sporulation
C0Z10_08300	COG1660	Displays ATPase and GTPase activities
C0Z10_08305	COG0322	excinuclease ABC activity
C0Z10_08330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0Z10_08345	COG0556	nucleotide-excision repair
C0Z10_08350	COG2801	Transposase and inactivated derivatives
C0Z10_08350	COG3415	Transposase
C0Z10_08355	COG0237	dephospho-CoA kinase activity
C0Z10_08360	COG0539	negative regulation of cytoplasmic translation
C0Z10_08380	COG1280	lysine exporter protein (LysE YggA)
C0Z10_08395	COG2050	protein possibly involved in aromatic compounds catabolism
C0Z10_08410	COG0469	pyruvate kinase activity
C0Z10_08420	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0Z10_08425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0Z10_08440	COG1799	cell septum assembly
C0Z10_08450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C0Z10_08460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0Z10_08465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0Z10_08475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C0Z10_08480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0Z10_08485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C0Z10_08495	COG0768	penicillin binding
C0Z10_08505	COG0275	rRNA processing
C0Z10_08510	COG2001	Belongs to the MraZ family
C0Z10_08515	COG0714	Associated with various cellular activities
C0Z10_08540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C0Z10_08545	COG0509	glycine decarboxylation via glycine cleavage system
C0Z10_08550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C0Z10_08550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C0Z10_08560	COG1131	(ABC) transporter
C0Z10_08575	COG3265	gluconokinase activity
C0Z10_08590	COG1116	anion transmembrane transporter activity
C0Z10_08610	COG0210	DNA helicase
C0Z10_08625	COG0142	geranyltranstransferase activity
C0Z10_08635	COG0515	serine threonine protein kinase
C0Z10_08635	COG2815	serine threonine protein kinase
C0Z10_08650	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C0Z10_08655	COG2197	response regulator
C0Z10_08680	COG1940	carbohydrate kinase activity
C0Z10_08685	COG3883	PFAM NLP P60 protein
C0Z10_08685	COG0791	NLP P60 protein
C0Z10_08725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0Z10_08735	COG1845	cytochrome c oxidase, subunit III
C0Z10_08740	COG2010	Cytochrome c
C0Z10_08745	COG0723	plastoquinol--plastocyanin reductase activity
C0Z10_08750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C0Z10_08775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0Z10_08780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0Z10_08820	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0Z10_08825	COG0321	lipoyl(octanoyl) transferase activity
C0Z10_08840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C0Z10_08850	COG0488	(ABC) transporter
C0Z10_08860	COG0438	transferase activity, transferring glycosyl groups
C0Z10_08875	COG0174	glutamine synthetase
C0Z10_08880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C0Z10_08885	COG2966	Psort location CytoplasmicMembrane, score
C0Z10_08890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C0Z10_08900	COG0174	glutamine synthetase
C0Z10_08925	COG0601	transmembrane transport
C0Z10_08940	COG0598	Magnesium transport protein CorA
C0Z10_08960	COG0531	amino acid
C0Z10_08965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C0Z10_08975	COG0006	proline dipeptidase activity
C0Z10_09005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0Z10_09010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0Z10_09025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C0Z10_09030	COG0297	glycogen (starch) synthase activity
C0Z10_09045	COG1611	Belongs to the LOG family
C0Z10_09050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0Z10_09055	COG2171	N-acyltransferase activity
C0Z10_09085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C0Z10_09090	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C0Z10_09095	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C0Z10_09100	COG2814	Major facilitator Superfamily
C0Z10_09135	COG0371	Dehydrogenase
C0Z10_09145	COG0647	UMP catabolic process
C0Z10_09155	COG0698	ribose 5-phosphate isomerase
C0Z10_09160	COG1349	DNA-binding transcription factor activity
C0Z10_09170	COG2376	Dihydroxyacetone kinase
C0Z10_09175	COG1063	alcohol dehydrogenase
C0Z10_09180	COG1012	belongs to the aldehyde dehydrogenase family
C0Z10_09195	COG4555	ABC transporter
C0Z10_09225	COG1121	(ABC) transporter
C0Z10_09230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0Z10_09250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0Z10_09255	COG0765	amino acid transport
C0Z10_09265	COG2501	S4 domain
C0Z10_09300	COG0667	Aldo Keto reductase
C0Z10_09305	COG2133	pyrroloquinoline quinone binding
C0Z10_09340	COG0477	Major facilitator Superfamily
C0Z10_09360	COG1335	isochorismatase
C0Z10_09365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0Z10_09380	COG1132	(ABC) transporter
C0Z10_09395	COG4115	mRNA cleavage
C0Z10_09400	COG2161	toxin-antitoxin pair type II binding
C0Z10_09465	COG0012	GTP binding
C0Z10_09475	COG1362	aminopeptidase activity
C0Z10_09480	COG1322	Protein conserved in bacteria
C0Z10_09485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C0Z10_09490	COG1570	exodeoxyribonuclease VII activity
C0Z10_09495	COG1722	exodeoxyribonuclease VII activity
C0Z10_09505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C0Z10_09515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0Z10_09520	COG1331	Highly conserved protein containing a thioredoxin domain
C0Z10_09535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0Z10_09550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0Z10_09555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0Z10_09590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C0Z10_09595	COG1438	arginine binding
C0Z10_09605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0Z10_09610	COG0072	phenylalanine-tRNA ligase activity
C0Z10_09610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0Z10_09615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C0Z10_09625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0Z10_09630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C0Z10_09635	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C0Z10_09640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C0Z10_09665	COG0494	nUDIX hydrolase
C0Z10_09710	COG0148	phosphopyruvate hydratase activity
C0Z10_09730	COG0193	aminoacyl-tRNA hydrolase activity
C0Z10_09735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C0Z10_09740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C0Z10_09745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0Z10_09760	COG1846	Transcriptional regulator
C0Z10_09765	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C0Z10_09770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0Z10_09775	COG0084	hydrolase, TatD family'
C0Z10_09790	COG2233	PERMEase
C0Z10_09795	COG0515	serine threonine protein kinase
C0Z10_09800	COG1984	allophanate hydrolase subunit 2
C0Z10_09805	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C0Z10_09835	COG0477	Major facilitator Superfamily
C0Z10_09850	COG0789	Transcriptional regulator
C0Z10_09880	COG0673	inositol 2-dehydrogenase activity
C0Z10_09895	COG0640	Transcriptional regulator
C0Z10_09910	COG0628	permease
C0Z10_09940	COG2801	Transposase and inactivated derivatives
C0Z10_09950	COG2217	Heavy metal translocating P-type atpase
C0Z10_10030	COG0673	inositol 2-dehydrogenase activity
C0Z10_10035	COG2814	Major facilitator Superfamily
C0Z10_10055	COG3962	Belongs to the TPP enzyme family
C0Z10_10060	COG3718	enzyme involved in inositol metabolism
C0Z10_10070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0Z10_10075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0Z10_10080	COG3118	belongs to the thioredoxin family
C0Z10_10085	COG2226	methyltransferase
C0Z10_10090	COG1321	iron dependent repressor
C0Z10_10100	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C0Z10_10115	COG2252	PERMEase
C0Z10_10125	COG1278	Cold shock
C0Z10_10130	COG0390	transport system, permease component
C0Z10_10135	COG0363	glucosamine-6-phosphate deaminase activity
C0Z10_10165	COG1609	Transcriptional regulator
C0Z10_10185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0Z10_10185	COG1648	precorrin-2 dehydrogenase activity
C0Z10_10205	COG1492	cobalamin metabolic process
C0Z10_10210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C0Z10_10215	COG2197	response regulator
C0Z10_10255	COG3189	MarR family transcriptional regulator
C0Z10_10260	COG0156	8-amino-7-oxononanoate synthase activity
C0Z10_10265	COG1063	alcohol dehydrogenase
C0Z10_10270	COG1760	l-serine dehydratase
C0Z10_10280	COG3842	ATPase activity
C0Z10_10290	COG0626	cystathionine gamma-synthase activity
C0Z10_10305	COG0215	cysteine-tRNA ligase activity
C0Z10_10310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0Z10_10315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C0Z10_10320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0Z10_10335	COG4948	Mandelate Racemase Muconate Lactonizing
C0Z10_10345	COG0534	Mate efflux family protein
C0Z10_10350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C0Z10_10355	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C0Z10_10365	COG2390	Transcriptional regulator
C0Z10_10370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C0Z10_10380	COG3775	system Galactitol-specific IIC component
C0Z10_10395	COG1329	Transcriptional regulator
C0Z10_10410	COG5002	protein histidine kinase activity
C0Z10_10415	COG0704	Plays a role in the regulation of phosphate uptake
C0Z10_10420	COG0588	phosphoglycerate mutase activity
C0Z10_10425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0Z10_10430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0Z10_10460	COG3739	integral membrane protein
C0Z10_10465	COG0191	fructose-bisphosphate aldolase activity
C0Z10_10480	COG0586	Pfam SNARE associated Golgi protein
C0Z10_10485	COG1704	LemA family
C0Z10_10510	COG4176	ABC-type proline glycine betaine transport system permease component
C0Z10_10515	COG4175	Glycine betaine
C0Z10_10515	COG0517	IMP dehydrogenase activity
C0Z10_10520	COG3012	SEC-C Motif Domain Protein
C0Z10_10535	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C0Z10_10545	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C0Z10_10565	COG0076	glutamate decarboxylase activity
C0Z10_10570	COG3012	SEC-C Motif Domain Protein
C0Z10_10585	COG3158	transport of potassium into the cell
C0Z10_10600	COG0542	response to heat
C0Z10_10610	COG0395	ABC-type sugar transport system, permease component
C0Z10_10625	COG3588	fructose-bisphosphate aldolase
C0Z10_10640	COG2197	response regulator
C0Z10_10650	COG4591	ABC-type transport system involved in lipoprotein release permease component
C0Z10_10650	COG1136	(ABC) transporter
C0Z10_10655	COG0577	efflux transmembrane transporter activity
C0Z10_10655	COG1136	(ABC) transporter
C0Z10_10660	COG1113	amino acid transport
C0Z10_10665	COG0569	domain protein
C0Z10_10665	COG2985	domain, Protein
C0Z10_10670	COG3527	Alpha-acetolactate decarboxylase
C0Z10_10680	COG0789	Transcriptional regulator
C0Z10_10685	COG0484	heat shock protein binding
C0Z10_10690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C0Z10_10715	COG0745	RESPONSE REGULATOR receiver
C0Z10_10720	COG2205	protein histidine kinase activity
C0Z10_10725	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C0Z10_10730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C0Z10_10740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C0Z10_10740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C0Z10_10750	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C0Z10_10765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0Z10_10765	COG0574	Belongs to the PEP-utilizing enzyme family
C0Z10_10770	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C0Z10_10775	COG2813	Specifically methylates the guanine in position
C0Z10_10780	COG0560	Phosphoserine phosphatase
C0Z10_10780	COG3830	Belongs to the UPF0237 family
C0Z10_10785	COG0676	glucose-6-phosphate 1-epimerase activity
C0Z10_10800	COG0546	phosphoglycolate phosphatase activity
C0Z10_10825	COG4608	Belongs to the ABC transporter superfamily
C0Z10_10850	COG1609	Transcriptional regulator
C0Z10_10860	COG2188	Transcriptional regulator
C0Z10_10885	COG3959	Transketolase, thiamine diphosphate binding domain
C0Z10_10890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0Z10_10905	COG0281	malic enzyme
C0Z10_10910	COG0673	inositol 2-dehydrogenase activity
C0Z10_10920	COG2814	Major facilitator Superfamily
C0Z10_10925	COG1082	Xylose isomerase domain protein TIM barrel
C0Z10_10930	COG0673	inositol 2-dehydrogenase activity
C0Z10_10935	COG3718	enzyme involved in inositol metabolism
C0Z10_10945	COG1414	Transcriptional regulator
C0Z10_10955	COG3428	Bacterial PH domain
C0Z10_10965	COG0018	arginyl-trna synthetase
C0Z10_10970	COG0656	L-ascorbic acid biosynthetic process
C0Z10_10975	COG2814	Major facilitator Superfamily
C0Z10_10980	COG2949	membrane
C0Z10_10985	COG0747	negative chemotaxis
C0Z10_10990	COG0601	transmembrane transport
C0Z10_10995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0Z10_11000	COG0444	Belongs to the ABC transporter superfamily
C0Z10_11010	COG0166	Belongs to the GPI family
C0Z10_11025	COG4581	dead DEAH box helicase
C0Z10_11050	COG0667	Aldo Keto reductase
C0Z10_11055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0Z10_11060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0Z10_11075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C0Z10_11085	COG2814	Major facilitator Superfamily
C0Z10_11090	COG0861	Integral membrane protein TerC family
C0Z10_11095	COG0726	polysaccharide deacetylase
C0Z10_11115	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C0Z10_11120	COG0561	phosphatase activity
C0Z10_11125	COG0561	phosphatase activity
C0Z10_11150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C0Z10_11155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C0Z10_11200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0Z10_11205	COG1695	Transcriptional regulator
C0Z10_11210	COG0477	Major facilitator Superfamily
C0Z10_11250	COG1051	belongs to the nudix hydrolase family
C0Z10_11275	COG0537	adenosine 5'-monophosphoramidase activity
C0Z10_11290	COG1122	ATPase activity
C0Z10_11325	COG2801	Transposase and inactivated derivatives
C0Z10_11335	COG1609	Transcriptional regulator
C0Z10_11340	COG2271	Major facilitator Superfamily
C0Z10_11380	COG0456	acetyltransferase
C0Z10_11420	COG0783	Belongs to the Dps family
C0Z10_11425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0Z10_11435	COG2217	Heavy metal translocating P-type atpase
C0Z10_11445	COG3189	MarR family transcriptional regulator
C0Z10_11525	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C0Z10_11530	COG1088	dTDP-glucose 4,6-dehydratase activity
C0Z10_11540	COG1716	ATPase activity
C0Z10_11545	COG1716	ATPase activity
C0Z10_11560	COG0768	penicillin binding
C0Z10_11565	COG0515	serine threonine protein kinase
C0Z10_11590	COG0393	Putative heavy-metal-binding
C0Z10_11605	COG1953	Uracil, thiamine, allantoin
C0Z10_11610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0Z10_11615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C0Z10_11640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C0Z10_11645	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C0Z10_11660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0Z10_11680	COG1454	alcohol dehydrogenase
C0Z10_11715	COG1271	oxidase subunit
C0Z10_11720	COG1294	oxidase, subunit
C0Z10_11725	COG4988	ABC transporter
C0Z10_11730	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C0Z10_11735	COG1556	Lactate utilization protein
C0Z10_11740	COG1139	Iron-sulfur cluster binding protein
C0Z10_11745	COG0247	lactate metabolic process
C0Z10_11750	COG1620	l-lactate permease
C0Z10_11755	COG2186	Transcriptional regulator
C0Z10_11760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0Z10_11760	COG0493	'glutamate synthase
C0Z10_11770	COG0167	dihydroorotate dehydrogenase activity
C0Z10_11775	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C0Z10_11785	COG2608	mercury ion transmembrane transporter activity
C0Z10_11790	COG1937	Protein conserved in bacteria
C0Z10_11795	COG0305	Participates in initiation and elongation during chromosome replication
C0Z10_11800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0Z10_11800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0Z10_11820	COG3118	belongs to the thioredoxin family
C0Z10_11845	COG2094	Belongs to the DNA glycosylase MPG family
C0Z10_11855	COG1643	Atp-dependent helicase
C0Z10_11870	COG2897	thiosulfate sulfurtransferase activity
C0Z10_11910	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C0Z10_11915	COG1126	abc transporter atp-binding protein
C0Z10_11920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0Z10_11925	COG0765	amino acid transport
C0Z10_11930	COG0765	amino acid transport
C0Z10_11965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0Z10_11980	COG0489	protein tyrosine kinase activity
C0Z10_12020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0Z10_12135	COG0739	heme binding
C0Z10_12135	COG1196	nuclear chromosome segregation
C0Z10_12135	COG0741	lytic transglycosylase activity
C0Z10_12210	COG1222	aaa ATPase
C0Z10_12235	COG2801	Transposase and inactivated derivatives
C0Z10_12235	COG3415	Transposase
C0Z10_12285	COG2132	Multicopper oxidase
C0Z10_12295	COG2205	protein histidine kinase activity
C0Z10_12300	COG0745	RESPONSE REGULATOR receiver
C0Z10_12365	COG1660	Displays ATPase and GTPase activities
C0Z10_12380	COG0626	cystathionine gamma-synthase activity
C0Z10_12385	COG0387	Pfam Sodium calcium exchanger
C0Z10_12390	COG2124	cytochrome p450
C0Z10_12405	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C0Z10_12445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C0Z10_12450	COG5002	protein histidine kinase activity
C0Z10_12450	COG2176	DNA-directed DNA polymerase activity
C0Z10_12470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0Z10_12490	COG0686	Belongs to the AlaDH PNT family
C0Z10_12495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0Z10_12505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0Z10_12525	COG0543	2 iron, 2 sulfur cluster binding
C0Z10_12525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0Z10_12545	COG0745	RESPONSE REGULATOR receiver
C0Z10_12555	COG0390	transport system, permease component
C0Z10_12560	COG0671	phosphoesterase, PA-phosphatase related
C0Z10_12565	COG1968	undecaprenyl-diphosphatase activity
C0Z10_12570	COG0745	RESPONSE REGULATOR receiver
C0Z10_12585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0Z10_12590	COG1937	Protein conserved in bacteria
C0Z10_12595	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0Z10_12640	COG1201	RNA secondary structure unwinding
C0Z10_12650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0Z10_12665	COG1401	restriction endodeoxyribonuclease activity
C0Z10_12675	COG1401	restriction endodeoxyribonuclease activity
C0Z10_12685	COG1268	BioY protein
C0Z10_12695	COG0183	Belongs to the thiolase family
C0Z10_12705	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C0Z10_12705	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C0Z10_12710	COG1486	melibiose metabolic process
C0Z10_12715	COG2326	polyphosphate kinase activity
C0Z10_12735	COG3386	PFAM SMP-30 Gluconolaconase
C0Z10_12740	COG0477	Major facilitator Superfamily
C0Z10_12750	COG2197	response regulator
C0Z10_12760	COG2261	transglycosylase associated protein
C0Z10_12765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0Z10_12770	COG0352	thiamine-phosphate diphosphorylase activity
C0Z10_12775	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C0Z10_12780	COG0477	Major facilitator Superfamily
C0Z10_12785	COG0351	phosphomethylpyrimidine kinase
C0Z10_12785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C0Z10_12785	COG0352	thiamine-phosphate diphosphorylase activity
C0Z10_12790	COG1968	undecaprenyl-diphosphatase activity
C0Z10_12795	COG0359	binds to the 23S rRNA
C0Z10_12800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C0Z10_12805	COG0629	single-stranded DNA binding
C0Z10_12810	COG0360	Binds together with S18 to 16S ribosomal RNA
C0Z10_12820	COG2837	iron assimilation
C0Z10_12830	COG0672	)-iron permease
C0Z10_12840	COG1022	Amp-dependent synthetase and ligase
C0Z10_12850	COG0300	oxidoreductase activity
C0Z10_12890	COG0277	FAD linked oxidase domain protein
C0Z10_12895	COG5433	transposase activity
C0Z10_12905	COG4585	Histidine kinase
C0Z10_12910	COG0247	lactate metabolic process
C0Z10_12915	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C0Z10_12920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C0Z10_12950	COG1083	cytidylyl-transferase
C0Z10_12955	COG2089	acid synthase
C0Z10_12965	COG1216	Glycosyl transferase, family 2
C0Z10_12975	COG1215	transferase activity, transferring glycosyl groups
C0Z10_13000	COG3306	glycosyltransferase involved in LPS biosynthesis
C0Z10_13020	COG0489	protein tyrosine kinase activity
C0Z10_13080	COG0534	Mate efflux family protein
C0Z10_13090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0Z10_13135	COG2391	methyltransferase activity
C0Z10_13140	COG0425	Belongs to the sulfur carrier protein TusA family
C0Z10_13145	COG1716	ATPase activity
C0Z10_13145	COG0842	Transport permease protein
C0Z10_13145	COG1131	(ABC) transporter
C0Z10_13150	COG0515	serine threonine protein kinase
C0Z10_13160	COG0205	6-phosphofructokinase activity
C0Z10_13165	COG2267	carboxylic ester hydrolase activity
C0Z10_13170	COG5002	protein histidine kinase activity
C0Z10_13190	COG3842	ATPase activity
C0Z10_13195	COG2271	Major facilitator Superfamily
C0Z10_13215	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C0Z10_13250	COG2848	UPF0210 protein
C0Z10_13255	COG3830	Belongs to the UPF0237 family
C0Z10_13265	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C0Z10_13280	COG0668	transmembrane transport
C0Z10_13285	COG1929	Belongs to the glycerate kinase type-1 family
C0Z10_13290	COG0617	tRNA 3'-terminal CCA addition
C0Z10_13305	COG0515	serine threonine protein kinase
C0Z10_13305	COG2815	serine threonine protein kinase
C0Z10_13310	COG1595	DNA-templated transcription, initiation
C0Z10_13320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C0Z10_13325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C0Z10_13330	COG2390	Transcriptional regulator
C0Z10_13335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0Z10_13350	COG0564	pseudouridine synthase activity
C0Z10_13380	COG2066	Belongs to the glutaminase family
C0Z10_13405	COG4585	Histidine kinase
C0Z10_13415	COG1082	Xylose isomerase domain protein TIM barrel
C0Z10_13420	COG2188	Transcriptional regulator
C0Z10_13430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0Z10_13435	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0Z10_13445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0Z10_13445	COG0519	Catalyzes the synthesis of GMP from XMP
C0Z10_13455	COG1475	DNA binding
C0Z10_13460	COG1192	Involved in chromosome partitioning
C0Z10_13465	COG0357	Ribosomal RNA small subunit methyltransferase G
C0Z10_13475	COG0706	membrane insertase activity
C0Z10_13485	COG0594	ribonuclease P activity
C0Z10_13490	COG0230	Belongs to the bacterial ribosomal protein bL34 family