locus-tag class description JS278_00001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) JS278_00003 ENOG4107R34 abc transporter permease protein JS278_00004 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) JS278_00006 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) JS278_00007 ENOG4105K7N UPF0232 protein JS278_00009 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) JS278_00010 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) JS278_00014 ENOG4105ETE Transcriptional regulator (LacI family JS278_00015 ENOG4105C2J ABC transporter JS278_00016 ENOG4105CNN ABC, transporter JS278_00017 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator JS278_00018 ENOG4108RVA ribokinase JS278_00019 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) JS278_00024 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr JS278_00027 ENOG4106F59 XRE family Transcriptional regulator JS278_00028 ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A JS278_00031 ENOG4108J9M Transporter JS278_00036 ENOG4105C6K Malic enzyme JS278_00037 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) JS278_00038 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) JS278_00040 ENOG4105XYF acetyltransferase JS278_00042 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) JS278_00043 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) JS278_00045 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) JS278_00046 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) JS278_00047 ENOG4105W0E 50S ribosomal protein L33 JS278_00048 ENOG4105WH1 Two component transcriptional regulator luxr family JS278_00051 ENOG4105CHM Aminotransferase JS278_00054 ENOG4107W7X Aldolase JS278_00056 ENOG4105CPQ Dehydrogenase JS278_00057 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) JS278_00058 ENOG4105DT3 PTS system, galactitol-specific IIc component JS278_00061 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase JS278_00064 ENOG4105DVE abc transporter atp-binding protein JS278_00066 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) JS278_00068 ENOG4105E5Q amino acid AbC transporter JS278_00069 ENOG4105CDA abc transporter atp-binding protein JS278_00070 ENOG4105CIH Imidazole acetol-phosphate transaminase JS278_00073 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component JS278_00074 ENOG4105EG2 ABC transporter, permease JS278_00089 ENOG4105C26 Dehydrogenase JS278_00095 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) JS278_00097 ENOG4105CKU formyltetrahydrofolate synthetase JS278_00102 ENOG4105CRP Part of the ABC transporter FtsEX involved in JS278_00103 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) JS278_00104 ENOG4105WH1 Two component transcriptional regulator luxr family JS278_00105 ENOG4105E0Y RtcB Protein JS278_00110 ENOG4105F9F transposase JS278_00113 ENOG4105EDW glycosyl transferase, family 39 JS278_00115 ENOG4105BZU Histidine kinase JS278_00116 ENOG4105EDW glycosyl transferase, family 39 JS278_00117 ENOG4105BZU Histidine kinase JS278_00122 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) JS278_00125 ENOG410635A Membrane JS278_00130 ENOG4105CH2 amidohydrolase JS278_00132 ENOG4105CV8 reductase JS278_00133 ENOG4105K6T rare lipoprotein A JS278_00134 ENOG4107TTQ Alpha beta hydrolase fold JS278_00136 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) JS278_00139 ENOG4105ZMH deoxynucleoside kinase JS278_00140 ENOG41067SE Tetr family transcriptional regulator JS278_00141 ENOG4105EYF MMPL domain protein JS278_00143 ENOG4108RYK Nad-dependent epimerase dehydratase JS278_00144 ENOG4105KVH Transcriptional regulator JS278_00145 ENOG4105C3M thioredoxin reductase JS278_00150 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) JS278_00151 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) JS278_00155 ENOG4105D9P serine threonine protein kinase JS278_00158 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein JS278_00159 ENOG4105C09 Bile acid JS278_00160 ENOG4105C26 Dehydrogenase JS278_00161 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate JS278_00162 ENOG4105BZW Glycerate kinase JS278_00164 ENOG4105D8X mechanosensitive ion channel JS278_00166 ENOG4105CXT aspartate transcarbamylase JS278_00167 ENOG4105CTZ aminopeptidase c JS278_00169 ENOG41064HX Suppressor of fused protein (SUFU) JS278_00170 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) JS278_00172 ENOG4105C9Q fumarate hydratase class II JS278_00175 ENOG4105CMQ Chloride channel JS278_00181 ENOG4105E2D ec 3.2.1.52 JS278_00185 ENOG4105DPZ Two component transcriptional regulator (Winged helix family JS278_00189 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) JS278_00191 ENOG4105K6T rare lipoprotein A JS278_00200 ENOG4105E5G Alpha beta hydrolase fold JS278_00201 ENOG4105DCF alanine dehydrogenase JS278_00202 ENOG4105CTQ phosphohexokinase JS278_00203 ENOG4105C26 Dehydrogenase JS278_00206 ENOG4108QVN serine threonine protein kinase JS278_00207 ENOG4105IDI abc transporter atp-binding protein JS278_00208 ENOG4108DWA Nad synthetase JS278_00210 ENOG4106FRU abrb family transcriptional regulator JS278_00212 ENOG410839S Toxic component of a toxin-antitoxin (TA) module (By similarity) JS278_00213 ENOG4105D7K pfkb domain protein JS278_00214 ENOG4108HKT sucrose-6-phosphate hydrolase JS278_00218 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase JS278_00219 ENOG4105CHR reductase JS278_00220 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) JS278_00221 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) JS278_00226 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) JS278_00229 ENOG4105ETE Transcriptional regulator (LacI family JS278_00231 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component JS278_00233 ENOG4108Z66 YbaK ebsC protein JS278_00234 ENOG4108TFM Kinase, PfkB family JS278_00255 ENOG4105C85 amino acid JS278_00257 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes JS278_00262 ENOG4105C5I Dehydrogenase JS278_00265 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A JS278_00266 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B JS278_00267 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) JS278_00269 ENOG4105CDA abc transporter atp-binding protein JS278_00275 ENOG4105CJ1 ABC, transporter JS278_00277 ENOG4105WH1 Two component transcriptional regulator luxr family JS278_00278 ENOG4105BZU Histidine kinase JS278_00282 ENOG4105CQB FAD linked oxidase domain protein JS278_00291 ENOG4108IXY short-chain dehydrogenase reductase JS278_00293 ENOG4108IQE Amp-dependent synthetase and ligase JS278_00301 ENOG4105DBE peroxidase JS278_00302 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) JS278_00304 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) JS278_00305 ENOG4105K9Q Binds to the 23S rRNA (By similarity) JS278_00307 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) JS278_00309 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase JS278_00312 ENOG4105PGM cation diffusion facilitator family transporter JS278_00314 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) JS278_00316 ENOG41062D9 Histidine kinase JS278_00320 ENOG4105BZ1 (ABC) transporter JS278_00321 ENOG4105BZ1 (ABC) transporter JS278_00323 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic JS278_00324 ENOG4105CG3 alpha amylase, catalytic region JS278_00325 ENOG4105DRS transport system, permease JS278_00326 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component JS278_00329 ENOG4105EBR Carboxylesterase JS278_00333 ENOG4105KT7 mgtC SapB transporter JS278_00335 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component JS278_00336 ENOG4105DRS transport system, permease JS278_00337 ENOG4105BZ7 extracellular solute-binding protein family 1 JS278_00339 ENOG4107QK4 glycoside hydrolase, family 3 domain protein JS278_00344 ENOG4105ETE Transcriptional regulator (LacI family JS278_00346 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component JS278_00349 ENOG4105ETE Transcriptional regulator (LacI family JS278_00351 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component JS278_00352 ENOG4105DRS transport system, permease JS278_00358 ENOG4105CG3 alpha amylase, catalytic region JS278_00359 ENOG4105ETE Transcriptional regulator (LacI family JS278_00365 ENOG4107QHQ amino acid JS278_00366 ENOG4105CHR reductase JS278_00367 ENOG4105C85 amino acid JS278_00368 ENOG4105DCF alanine dehydrogenase JS278_00385 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E JS278_00386 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase JS278_00388 ENOG4105CPP Dehydrogenase, E1 component JS278_00389 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 JS278_00391 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) JS278_00393 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) JS278_00396 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) JS278_00399 ENOG4105EG2 ABC transporter, permease JS278_00402 ENOG4105ETE Transcriptional regulator (LacI family JS278_00403 ENOG4108K4B hydrolase JS278_00413 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) JS278_00414 ENOG4105ETE Transcriptional regulator (LacI family JS278_00420 ENOG4108QXE glycerophosphoryl diester phosphodiesterase JS278_00421 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein JS278_00422 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein JS278_00426 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) JS278_00428 ENOG4108Z6B deaminase JS278_00436 ENOG4105E90 ABC transporter JS278_00438 ENOG4108IJ8 ABC transporter JS278_00439 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) JS278_00450 ENOG4105FDP GntR family transcriptional regulator JS278_00454 ENOG41090U3 tautomerase JS278_00455 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) JS278_00457 ENOG4105C29 acyl-CoA thioesterase JS278_00461 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) JS278_00462 ENOG4105KPI PTS system sorbose subfamily IIB component JS278_00463 ENOG4105F3R pts system mannose fructose sorbose family iid JS278_00464 ENOG4105ETZ PTS System JS278_00465 ENOG4105FDP GntR family transcriptional regulator JS278_00468 ENOG4105CMT Dihydroxyacetone kinase JS278_00470 ENOG4105ETE Transcriptional regulator (LacI family JS278_00471 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component JS278_00472 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component JS278_00476 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) JS278_00477 ENOG4107HP6 Transcriptional regulator JS278_00479 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin JS278_00480 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) JS278_00481 ENOG4105DKT Transcriptional regulator JS278_00482 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) JS278_00485 ENOG4107W7X Aldolase JS278_00486 ENOG4105CV8 reductase JS278_00487 ENOG41061GT Aldolase JS278_00488 ENOG4105CPQ Dehydrogenase JS278_00490 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) JS278_00491 ENOG4105C54 Major Facilitator superfamily JS278_00492 ENOG410804X Transcriptional regulator JS278_00493 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase JS278_00495 ENOG4105CJQ hydrolase, family 31 JS278_00496 ENOG4105CT4 transporter JS278_00497 ENOG4107QKS N-acylglucosamine 2-epimerase JS278_00498 ENOG4105D2M Aldolase JS278_00503 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) JS278_00511 ENOG4105WS7 Cation transport regulator JS278_00514 ENOG41061TZ Short-chain dehydrogenase reductase Sdr JS278_00516 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) JS278_00519 ENOG4105CYX Short-chain dehydrogenase reductase Sdr JS278_00523 ENOG4105CH6 catalase JS278_00527 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) JS278_00534 ENOG4107S2Z UPF0761 membrane protein JS278_00541 ENOG4107QI1 Mate efflux family protein JS278_00545 ENOG4105E7D Protein of unknown function (DUF3375) JS278_00548 ENOG4105F9F transposase JS278_00550 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) JS278_00553 ENOG4107Z1W Fructose transport system kinase JS278_00554 ENOG4105EF1 ribulokinase JS278_00556 ENOG4105NRA 50s ribosomal protein l31 type b JS278_00557 ENOG4105D1Q UPF0246 protein JS278_00559 ENOG4108JQ7 (ABC) transporter JS278_00560 ENOG4105C3U ABC transporter JS278_00561 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component JS278_00562 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component JS278_00568 ENOG410834F Transcriptional regulator JS278_00569 ENOG4107QK5 Homocysteine s-methyltransferase JS278_00570 ENOG4108IQI permease JS278_00578 ENOG4108JQC penicillin-binding protein 1A JS278_00579 ENOG4105BZ4 penicillin-binding protein JS278_00586 ENOG4105P8F nudix hydrolase JS278_00610 ENOG4105K4U addiction module toxin, RelE StbE family JS278_00611 ENOG4108I5C dEAD DEAH box helicase JS278_00612 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) JS278_00614 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) JS278_00616 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) JS278_00617 ENOG4105C6E dna polymerase iii JS278_00619 ENOG4105MA4 psp1 domain protein JS278_00624 ENOG4105KRQ Addiction module toxin, Txe YoeB family JS278_00625 ENOG41084HI prevent-host-death family JS278_00630 ENOG4108YYH Nadph-dependent fmn reductase JS278_00631 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) JS278_00635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component JS278_00636 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component JS278_00638 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A JS278_00639 ENOG4105EW9 transcriptional regulator AsnC family JS278_00650 ENOG4105I82 acetyl xylan esterase JS278_00652 ENOG4105F0N pyrophosphate phospho-hydrolase JS278_00654 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) JS278_00655 ENOG4108UGV hypoxanthine phosphoribosyltransferase JS278_00657 ENOG4105EUJ GTP cyclohydrolase i JS278_00660 ENOG4105EEI dihydropteroate synthase JS278_00665 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JS278_00667 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit JS278_00670 ENOG4105DVF Cytosine-specific methyltransferase JS278_00686 ENOG4107ZXI Rhomboid family JS278_00688 ENOG4105DP9 ABC transporter JS278_00690 ENOG4108UCS ABC, transporter JS278_00694 ENOG4105CEN a g-specific adenine glycosylase JS278_00695 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase JS278_00696 ENOG4105D52 delta-aminolevulinic acid dehydratase JS278_00698 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) JS278_00700 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) JS278_00701 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) JS278_00702 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) JS278_00705 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) JS278_00707 ENOG4105EY0 Xylose isomerase domain protein TIM barrel JS278_00711 ENOG4105II7 pyrroline-5-carboxylate reductase JS278_00712 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) JS278_00713 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) JS278_00714 ENOG4108RH7 phosphoglycerate mutase JS278_00715 ENOG4107ZT5 Thiol disulfide interchange protein JS278_00716 ENOG4107QIV Cytochrome c biogenesis protein JS278_00718 ENOG4105CRE cytochrome C JS278_00722 ENOG4105C6V Glycerol-3-phosphate dehydrogenase JS278_00724 ENOG4105C7B Threonine dehydratase JS278_00725 ENOG4105C01 Dihydroxy-acid dehydratase JS278_00729 ENOG4105E0A ABC, transporter JS278_00730 ENOG4108IHU transport system permease protein JS278_00731 ENOG4105DQ5 transport system permease protein JS278_00732 ENOG4108MES Periplasmic binding protein JS278_00733 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) JS278_00734 ENOG4105E2Z phosphate ABC transporter (Permease JS278_00738 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) JS278_00739 ENOG4107NHD transcriptional regulator JS278_00743 ENOG4108M8W Monooxygenase JS278_00745 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) JS278_00748 ENOG4108SVG May play a role in the intracellular transport of hydrophobic ligands JS278_00749 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) JS278_00754 ENOG4105CI3 gtp-binding protein typa JS278_00756 ENOG4105XTG Pfam:DUF156 JS278_00759 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis JS278_00762 ENOG4105VJK Transcription factor JS278_00764 ENOG4105C83 adenylosuccinate lyase JS278_00765 ENOG4105C8V SAICAR synthetase JS278_00766 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I JS278_00767 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) JS278_00769 ENOG4105HDK L-asparaginase JS278_00771 ENOG4105DJT lAO AO transport system ATPase JS278_00772 ENOG4107QIK phosphoribosylformylglycinamidine synthase JS278_00777 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) JS278_00780 ENOG4105CXB phosphoribosylaminoimidazole synthetase JS278_00785 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component JS278_00809 ENOG4105E4C Lytic transglycosylase catalytic JS278_00835 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) JS278_00844 ENOG4106KE4 Dehydrogenase JS278_00854 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) JS278_00857 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) JS278_00861 ENOG4105DEN Luciferase family JS278_00869 ENOG4108Z6B deaminase JS278_00870 ENOG4105VDH Dihydroxyacetone kinase JS278_00871 ENOG4108UTZ Dihydroxyacetone kinase JS278_00872 ENOG4105CMT Dihydroxyacetone kinase JS278_00876 ENOG4105BZ1 (ABC) transporter JS278_00878 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) JS278_00883 ENOG4105E4F Isochorismate synthase JS278_00884 ENOG4105P52 geranylgeranyl reductase JS278_00886 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JS278_00887 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain JS278_00888 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JS278_00890 ENOG4107QIZ NADH dehydrogenase JS278_00891 ENOG4108IEH NADH dehydrogenase subunit g JS278_00892 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) JS278_00893 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JS278_00894 ENOG4105DF2 NADH dehydrogenase subunit j JS278_00895 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JS278_00898 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JS278_00901 ENOG4105C9K Endothelin-converting enzyme 1 JS278_00902 ENOG4105DQU oxidoreductase, subunit beta JS278_00903 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein JS278_00904 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JS278_00906 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JS278_00907 ENOG41072RD Membrane JS278_00914 ENOG4105WDJ 50S ribosomal protein L33 JS278_00915 ENOG410900P UPF0336 protein JS278_00917 ENOG4107R4N Cell wall formation (By similarity) JS278_00918 ENOG4105XT2 Transcriptional regulator JS278_00921 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) JS278_00922 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) JS278_00923 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) JS278_00924 ENOG4108VZM 50s ribosomal protein L10 JS278_00925 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) JS278_00926 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) JS278_00927 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) JS278_00930 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) JS278_00931 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) JS278_00932 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) JS278_00933 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) JS278_00936 ENOG4105CX6 glutaminyL-tRNA synthetase JS278_00937 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) JS278_00938 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) JS278_00939 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) JS278_00940 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) JS278_00941 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) JS278_00942 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity JS278_00943 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) JS278_00944 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) JS278_00945 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) JS278_00946 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) JS278_00947 ENOG41082SA 50s ribosomal protein l29 JS278_00948 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal JS278_00950 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) JS278_00951 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) JS278_00952 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits JS278_00953 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) JS278_00954 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) JS278_00955 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) JS278_00956 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) JS278_00957 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) JS278_00958 ENOG410849U 50S ribosomal protein L30 JS278_00959 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) JS278_00966 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) JS278_00970 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) JS278_00971 ENOG41067V7 50S ribosomal protein L36 JS278_00972 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits JS278_00973 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) JS278_00974 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) JS278_00975 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) JS278_00976 ENOG4108ZT0 50S ribosomal protein l17 JS278_00977 ENOG4105F9F transposase JS278_00978 ENOG4105MP0 transposase JS278_00980 ENOG4108MJN Glycosyl Transferase JS278_00982 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) JS278_00983 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) JS278_00985 ENOG4105BZ1 (ABC) transporter JS278_00986 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) JS278_00988 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) JS278_00989 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) JS278_00990 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) JS278_00992 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) JS278_00993 ENOG4108UJD 30S ribosomal protein S9 JS278_00994 ENOG4105CHR reductase JS278_00995 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) JS278_00997 ENOG4105CS9 pantothenic acid kinase JS278_00998 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) JS278_00999 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) JS278_01000 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) JS278_01003 ENOG4105C1J atp-dependent rna helicase JS278_01004 ENOG4108097 ATP-binding protein JS278_01007 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) JS278_01011 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein JS278_01015 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) JS278_01016 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) JS278_01017 ENOG41072RD Membrane JS278_01018 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) JS278_01020 ENOG4105EHE chorismate mutase- prephenate dehydrogenase JS278_01021 ENOG4105D7W serine acetyltransferase JS278_01022 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) JS278_01027 ENOG4105WH1 Two component transcriptional regulator luxr family JS278_01028 ENOG4105Y3U Transglycosylase-associated protein JS278_01029 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) JS278_01030 ENOG4108UMI ABC transporter, permease JS278_01031 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) JS278_01032 ENOG4105D01 (LipO)protein JS278_01036 ENOG4105CMV Succinyl-CoA synthetase subunit beta JS278_01042 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) JS278_01043 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) JS278_01045 ENOG4105DC1 bifunctional purine biosynthesis protein purh JS278_01047 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) JS278_01049 ENOG4108EKI Dehydrogenase JS278_01050 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) JS278_01052 ENOG4105E9K Isocitrate dehydrogenase JS278_01056 ENOG4107TFB basic membrane JS278_01057 ENOG4108JQ9 ABC transporter JS278_01058 ENOG4105UIB (ABC) transporter JS278_01064 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) JS278_01067 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain JS278_01071 ENOG4108JIK carboxylase JS278_01073 ENOG4105DWF phosphomethylpyrimidine kinase JS278_01076 ENOG4105CEU Arginine dihydrolase JS278_01078 ENOG4107WR6 Maf-like protein JS278_01080 ENOG4105D8K carboxyl transferase JS278_01082 ENOG4105EC3 peptidase S51, dipeptidase E JS278_01086 ENOG4108KGH TRANSCRIPTIONal JS278_01089 ENOG4105CJT Mannose-1-phosphate guanylyltransferase JS278_01091 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) JS278_01098 ENOG41076HS cation diffusion facilitator family transporter JS278_01099 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) JS278_01105 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) JS278_01108 ENOG4105CE1 Ferrous iron transport protein b JS278_01110 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) JS278_01111 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) JS278_01112 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) JS278_01113 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) JS278_01115 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) JS278_01116 ENOG4105WH1 Two component transcriptional regulator luxr family JS278_01117 ENOG4105BZU Histidine kinase JS278_01128 ENOG41089BK Glutamine amido-transferase JS278_01133 ENOG4105DFU Cell wall formation (By similarity) JS278_01136 ENOG4105C0B DNA polymerase III (alpha subunit) JS278_01137 ENOG4105CUB amino acid JS278_01153 ENOG4105C0D helicase JS278_01155 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) JS278_01156 ENOG4108R3E Dna-3-methyladenine glycosylase i JS278_01159 ENOG4105CPK Glycosyl transferase (Group 1 JS278_01162 ENOG4105KVH Transcriptional regulator JS278_01168 ENOG4105F5W AtP-binding protein JS278_01173 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) JS278_01178 ENOG4105CQB FAD linked oxidase domain protein JS278_01181 ENOG4108IQE Amp-dependent synthetase and ligase JS278_01187 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) JS278_01190 ENOG4105MC2 DSBA oxidoreductase JS278_01191 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) JS278_01197 ENOG4105CRK lysyL-tRNA synthetase JS278_01206 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) JS278_01212 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation JS278_01213 ENOG4105DSF transport protein JS278_01214 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) JS278_01215 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) JS278_01216 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) JS278_01218 ENOG4107RE3 peptidase, S41 JS278_01220 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) JS278_01222 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) JS278_01225 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) JS278_01226 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) JS278_01229 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for JS278_01230 ENOG4105ETE Transcriptional regulator (LacI family JS278_01231 ENOG4105EG2 ABC transporter, permease JS278_01232 ENOG4105D56 permease protein JS278_01235 ENOG4105DIW FeS assembly protein SUFB JS278_01238 ENOG4105C3K feS assembly ATPase SufC JS278_01239 ENOG4105C9B Cysteine desulfurase JS278_01240 ENOG4108UNV SUF system FeS assembly protein, NifU family JS278_01249 ENOG4105C5H ABC transporter JS278_01255 ENOG4105CHR reductase JS278_01259 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) JS278_01260 ENOG4105DKW ABC transporter JS278_01263 ENOG4105DHU Bile acid JS278_01274 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) JS278_01277 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) JS278_01280 ENOG4105DEG Vwa containing coxe family protein JS278_01281 ENOG4105RD5 JS278_01282 ENOG4105KKX ATPase associated with various cellular activities aaa_5 JS278_01283 ENOG4108KDT Molybdate metabolism regulator JS278_01284 ENOG4105CE9 30S ribosomal protein S2 JS278_01285 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) JS278_01286 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) JS278_01287 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) JS278_01288 ENOG4105KNE Phosphatidate cytidylyltransferase JS278_01289 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs JS278_01290 ENOG4105D82 Glutamate dehydrogenase JS278_01292 ENOG4105DZP Membrane-associated zinc metalloprotease JS278_01294 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) JS278_01297 ENOG4105RYD Toxic component of a toxin-antitoxin (TA) module. A JS278_01302 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) JS278_01306 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) JS278_01308 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) JS278_01309 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) JS278_01310 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) JS278_01311 ENOG4108MDK Dehydrogenase JS278_01313 ENOG4105VI0 Pts system, glucitol sorbitol-specific JS278_01314 ENOG4105DZY Pts system, glucitol sorbitol-specific JS278_01315 ENOG410787A Pts system, glucitol sorbitol-specific JS278_01318 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase JS278_01319 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) JS278_01320 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) JS278_01322 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) JS278_01323 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) JS278_01324 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) JS278_01326 ENOG4105C7K acetolactate synthase JS278_01328 ENOG4105CN5 Metallo-Beta-Lactamase JS278_01329 ENOG4105VB9 50S ribosomal protein l28 JS278_01332 ENOG4106H78 methyltransferase JS278_01333 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) JS278_01335 ENOG41084BZ 50S ribosomal protein L32 JS278_01336 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) JS278_01337 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) JS278_01344 ENOG4105K5M 30s ribosomal protein S16 JS278_01345 ENOG41082KU UPF0109 protein JS278_01346 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) JS278_01347 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) JS278_01350 ENOG4105E33 succinate dehydrogenase JS278_01351 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) JS278_01352 ENOG4107QYR Signal peptidase i JS278_01353 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) JS278_01355 ENOG41080R2 UPF0102 protein JS278_01356 ENOG4105C0P Mg chelatase subunit ChlI JS278_01362 ENOG4105DRS transport system, permease JS278_01363 ENOG4105ETE Transcriptional regulator (LacI family JS278_01364 ENOG4107QNK )-transporter JS278_01368 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) JS278_01369 ENOG4105ETE Transcriptional regulator (LacI family JS278_01372 ENOG4107QNK )-transporter JS278_01373 ENOG41060NJ transcriptional regulator JS278_01375 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) JS278_01377 ENOG4105CPC Aldo Keto reductase JS278_01380 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase JS278_01381 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) JS278_01388 ENOG4105DSU hydrolase JS278_01389 ENOG4105VKD bioY protein JS278_01390 ENOG4108JJB ABC transporter JS278_01393 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) JS278_01394 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) JS278_01395 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) JS278_01402 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) JS278_01406 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) JS278_01407 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) JS278_01409 ENOG4105CQR helicase JS278_01410 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) JS278_01411 ENOG4105K59 histidine triad (HIT) protein JS278_01413 ENOG4108ZP8 Acetolactate synthase small subunit JS278_01414 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase JS278_01418 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) JS278_01419 ENOG4105CM2 brancheD-chain amino acid aminotransferase JS278_01420 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) JS278_01422 ENOG4105ERH Fumarylacetoacetate hydrolase JS278_01426 ENOG41069M3 Transcriptional regulator JS278_01427 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) JS278_01428 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) JS278_01430 ENOG4105CPF Cell wall formation (By similarity) JS278_01433 ENOG4107QZI cell division protein FtsK JS278_01435 ENOG4105KAF membrAne JS278_01437 ENOG4107SET aldo keto reductase JS278_01439 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) JS278_01440 ENOG4105CAK Cell division ATP-binding protein ftsE JS278_01441 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) JS278_01442 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) JS278_01443 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase JS278_01444 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) JS278_01445 ENOG4105CAS nag kinase JS278_01446 ENOG4105C8Y Acetylornithine aminotransferase JS278_01447 ENOG4105DBV ornithine carbamoyltransferase JS278_01448 ENOG4105CH7 arginosuccinase JS278_01451 ENOG4108UJU UPF0301 protein JS278_01452 ENOG4105CK6 Two component transcriptional regulator (Winged helix family JS278_01453 ENOG4105BZU Histidine kinase JS278_01454 ENOG4105G3P Lipoprotein lpqB JS278_01456 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea JS278_01458 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving JS278_01462 ENOG4105DB7 PHP domain protein JS278_01464 ENOG4105C31 Tryptophanyl-tRNA synthetase JS278_01469 ENOG4105VEQ Cold shock protein JS278_01470 ENOG4105C4R Atp-dependent dna helicase JS278_01473 ENOG4105C7H Helicase, RecD TraA family JS278_01474 ENOG4107QKA exodeoxyribonuclease V beta JS278_01475 ENOG4105DSY exodeoxyribonuclease V, gamma JS278_01480 ENOG41063PX domain protein JS278_01482 ENOG4105DJZ UPF0182 protein JS278_01484 ENOG4107QK4 glycoside hydrolase, family 3 domain protein JS278_01488 ENOG4105DEF Extracellular solute-binding protein, family 5 JS278_01490 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component JS278_01492 ENOG4108JQ6 ABC transporter JS278_01493 ENOG4108JQ1 Dehydrogenase JS278_01494 ENOG4107TK4 histidinol-phosphate phosphatase JS278_01495 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) JS278_01496 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase JS278_01498 ENOG4105EMN RNA polymerase sigma factor JS278_01504 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 JS278_01506 ENOG4108URH decarboxylase JS278_01508 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) JS278_01509 ENOG4105D6E homoserine dehydrogenase JS278_01510 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) JS278_01512 ENOG4105VFB Binds the 23S rRNA (By similarity) JS278_01513 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) JS278_01514 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) JS278_01515 ENOG4107UIY sua5 ycio yrdc ywlc family protein JS278_01516 ENOG4105ESV Glycosyl transferase, family 4 JS278_01530 ENOG4105CEY Amp-dependent synthetase and ligase JS278_01533 ENOG4105CAQ asparagine synthetase JS278_01535 ENOG4105D7W serine acetyltransferase JS278_01538 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) JS278_01539 ENOG4106DE0 ATP synthase JS278_01540 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) JS278_01541 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) JS278_01542 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) JS278_01543 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) JS278_01544 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) JS278_01545 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) JS278_01549 ENOG4105EV9 Alpha Beta Hydrolase JS278_01551 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) JS278_01556 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 JS278_01561 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) JS278_01562 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) JS278_01563 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) JS278_01567 ENOG4105C3J Cysteine desulfurase JS278_01568 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) JS278_01573 ENOG4105CJ1 ABC, transporter JS278_01574 ENOG4108IY8 ABC, transporter JS278_01579 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) JS278_01580 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) JS278_01581 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) JS278_01582 ENOG4105C2W permease JS278_01585 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase JS278_01586 ENOG4105CRQ synthase (Component I) JS278_01589 ENOG4105DK0 Indole-3-glycerol phosphate synthase JS278_01590 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) JS278_01591 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) JS278_01592 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) JS278_01593 ENOG4105CBC glutamate synthase JS278_01599 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) JS278_01600 ENOG4105CIH Imidazole acetol-phosphate transaminase JS278_01601 ENOG4105ECC imidazole-glycerol-phosphate dehydratase JS278_01602 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) JS278_01603 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase JS278_01604 ENOG4105CDY transcriptional regulatory protein JS278_01605 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) JS278_01606 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) JS278_01607 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) JS278_01610 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) JS278_01611 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) JS278_01613 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) JS278_01614 ENOG4105D98 threonine synthase JS278_01615 ENOG4105C99 atpase involved in dna repair JS278_01617 ENOG4105CUT histidyl-tRNA synthetase JS278_01618 ENOG4105CIZ coA-substrate-specific enzyme activase JS278_01619 ENOG4107MVR Transcriptional regulator JS278_01621 ENOG4105C9M aspartyl-trna synthetase JS278_01622 ENOG4107CN4 Pfam:PhdYeFM JS278_01630 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) JS278_01631 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) JS278_01633 ENOG4105E2X shikimate dehydrogenase JS278_01634 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase JS278_01636 ENOG4105D49 3-dehydroquinate synthase JS278_01638 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) JS278_01639 ENOG410803B Involved in the transcription termination process (By similarity) JS278_01641 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) JS278_01642 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) JS278_01644 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP JS278_01645 ENOG4107QRT dEAD DEAH box helicase JS278_01646 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) JS278_01649 ENOG4107RSZ Primosomal protein n' JS278_01650 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) JS278_01652 ENOG4105DJV ribulose-phosphate 3-epimerase JS278_01654 ENOG4105C3R Methionine synthase JS278_01657 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) JS278_01658 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) JS278_01660 ENOG4105CAT Cytidine monophosphate kinase JS278_01661 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) JS278_01663 ENOG4108Z9K Osmotically inducible protein JS278_01666 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) JS278_01676 ENOG4105F5W AtP-binding protein JS278_01686 ENOG4105CSR polyphosphate kinase 2 JS278_01688 ENOG4105J4Q Transcriptional regulator JS278_01690 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family JS278_01692 ENOG4105C8Y Acetylornithine aminotransferase JS278_01697 ENOG4105W1N transcriptional regulator JS278_01700 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) JS278_01701 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) JS278_01702 ENOG4105DQE DNA ligase JS278_01705 ENOG4105CAF HipA N-terminal domain protein JS278_01710 ENOG4105DJ2 Major Facilitator Superfamily JS278_01713 ENOG4105CYC Transferase JS278_01715 ENOG4105DWV Homoserine O-trans-acetylase JS278_01716 ENOG4105DWV Homoserine O-trans-acetylase JS278_01718 ENOG4107R05 Transfers the fatty acyl group on membrane lipoproteins (By similarity) JS278_01719 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) JS278_01720 ENOG4105Q70 JS278_01721 ENOG4107VXM glycerophosphoryl diester phosphodiesterase JS278_01722 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) JS278_01723 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) JS278_01725 ENOG4105D22 carbon starvation protein JS278_01728 ENOG4105CUB amino acid JS278_01732 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB JS278_01734 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein JS278_01736 ENOG4105CBD Diacylglycerol kinase JS278_01737 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) JS278_01738 ENOG4107RTD sua5 ycio yrdc ywlc family protein JS278_01740 ENOG4107RJF diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90) JS278_01741 ENOG4107H3J ribonuclease JS278_01745 ENOG4108UW8 fha domain-containing protein JS278_01751 ENOG4105E2K Glycosyl transferase (Group 1 JS278_01752 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase JS278_01755 ENOG4105C22 threonyL-tRNA synthetase JS278_01756 ENOG4105DQ4 alcohol dehydrogenase JS278_01765 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) JS278_01766 ENOG4107QM5 aconitate hydratase JS278_01767 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) JS278_01768 ENOG4105C0X amino acid JS278_01769 ENOG4107VEG TrkA-N domain protein JS278_01773 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) JS278_01780 ENOG4105EPD Oligopeptide transporter, Opt family JS278_01782 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) JS278_01786 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) JS278_01789 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) JS278_01791 ENOG4105CQ7 ATP-dependent helicase JS278_01796 ENOG4105DHP deoxycytidine triphosphate deaminase JS278_01797 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) JS278_01798 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) JS278_01801 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) JS278_01802 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) JS278_01803 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) JS278_01805 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) JS278_01806 ENOG4107WI4 Aldose-1-epimerase JS278_01807 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) JS278_01809 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) JS278_01811 ENOG4105E98 transcriptional regulator DeoR family JS278_01812 ENOG4105WBV Transcriptional regulator JS278_01813 ENOG4105CEV competence damage-inducible protein JS278_01815 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) JS278_01817 ENOG4105KRQ Addiction module toxin, Txe YoeB family JS278_01820 ENOG4107T52 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) JS278_01821 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) JS278_01822 ENOG4107TYT Catalyzes the conversion of dihydroorotate to orotate (By similarity) JS278_01823 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) JS278_01824 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain JS278_01825 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain JS278_01827 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) JS278_01830 ENOG4105CPC Aldo Keto reductase JS278_01832 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) JS278_01835 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) JS278_01838 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) JS278_01841 ENOG4105DFA alanine racemase domain protein JS278_01842 ENOG4107QVM von Willebrand factor, type A JS278_01843 ENOG4107QVM von Willebrand factor, type A JS278_01845 ENOG4105C7R Atpase associated with various cellular activities aaa_3 JS278_01854 ENOG4105C0R drug resistance transporter emrb qaca subfamily JS278_01856 ENOG4108UGD Serine Threonine protein kinase JS278_01857 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) JS278_01859 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) JS278_01861 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family JS278_01865 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase JS278_01871 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) JS278_01872 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein JS278_01880 ENOG4105CVK Glutamate decarboxylase JS278_01882 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) JS278_01883 ENOG4108IYU L-aspartate oxidase JS278_01885 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) JS278_01887 ENOG41090R7 Ferric uptake JS278_01888 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) JS278_01889 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin JS278_01891 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) JS278_01893 ENOG4105EAD ABC transporter JS278_01894 ENOG4105E5Q amino acid AbC transporter JS278_01895 ENOG4105CT1 (ABC) transporter JS278_01896 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) JS278_01897 ENOG4105CPN adenine deaminase JS278_01898 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) JS278_01900 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) JS278_01912 ENOG4108IUX (ABC) transporter JS278_01913 ENOG4105WH1 Two component transcriptional regulator luxr family JS278_01914 ENOG4105BZU Histidine kinase JS278_01915 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) JS278_01916 ENOG4107AQZ Membrane JS278_01918 ENOG4105C9U ATP-dependent DNA helicase RecQ JS278_01920 ENOG4105CTS PTS system mannitol-specific JS278_01921 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase JS278_01923 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) JS278_01924 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) JS278_01925 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) JS278_01926 ENOG4105ECY inositol monophosphatase JS278_01932 ENOG4105CSH Transporter JS278_01934 ENOG4105CIG ABC transporter JS278_01936 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) JS278_01937 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) JS278_01939 ENOG4107SIQ Naphthoate synthase JS278_01941 ENOG4105E4F Isochorismate synthase JS278_01942 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) JS278_01943 ENOG4107TCW O-succinylbenzoate synthase JS278_01948 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) JS278_01949 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) JS278_01951 ENOG4105F8X type iii restriction JS278_01952 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 JS278_01954 ENOG4105C8T Leucyl-tRNA synthetase JS278_01958 ENOG4107ZXU DSBA oxidoreductase JS278_01970 ENOG4105W1N transcriptional regulator JS278_01976 ENOG4105CJ1 ABC, transporter JS278_01978 ENOG4107U32 Beta-lactamase domain protein JS278_01983 ENOG4107QMH DNA methylase JS278_01988 ENOG4105CVJ phosphoglycerate mutase JS278_01990 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) JS278_01992 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) JS278_01993 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) JS278_01994 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control JS278_01996 ENOG4105K46 50S ribosomal protein l27 JS278_01997 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) JS278_01998 ENOG4105C03 ribonuclease JS278_02000 ENOG4105D17 glycoside hydrolase, family 3 domain protein JS278_02002 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) JS278_02004 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase JS278_02007 ENOG4105CP7 Triose-phosphate isomerase JS278_02008 ENOG4105BZA Phosphoglycerate kinase JS278_02009 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase JS278_02010 ENOG4105CIE May be required for sporulation (By similarity) JS278_02012 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) JS278_02013 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) JS278_02016 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) JS278_02019 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) JS278_02020 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) JS278_02021 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) JS278_02026 ENOG4105KA0 thioesterase Superfamily protein JS278_02029 ENOG4105CA9 Pyruvate kinase JS278_02031 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) JS278_02032 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters JS278_02035 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) JS278_02036 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase JS278_02037 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) JS278_02039 ENOG4105DFU Cell wall formation (By similarity) JS278_02040 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) JS278_02041 ENOG4105CNI cell division protein FtsW JS278_02042 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) JS278_02043 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) JS278_02046 ENOG4105CJN penicillin-binding protein JS278_02048 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) JS278_02049 ENOG4108V6E Cell division protein mraZ JS278_02050 ENOG4105C7R Atpase associated with various cellular activities aaa_3 JS278_02052 ENOG4105F8C transglutaminase domain-containing protein JS278_02054 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) JS278_02055 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) JS278_02056 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor JS278_02058 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family JS278_02059 ENOG4105C6Z Gluconate JS278_02060 ENOG4108J5G 6-phosphogluconate dehydrogenase JS278_02063 ENOG4105D7T ABC transporter JS278_02068 ENOG4105EAH synthase JS278_02069 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) JS278_02074 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase JS278_02075 ENOG4105WH1 Two component transcriptional regulator luxr family JS278_02079 ENOG4105DKQ ROK family JS278_02088 ENOG4107S1N anthranilate phosphoribosyltransferase JS278_02090 ENOG4105CCU oxidase (Subunit III) JS278_02091 ENOG4107UDY cytochrome C JS278_02092 ENOG4107EUI c reductase, iron-sulfur JS278_02093 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) JS278_02096 ENOG4108ZRS Part of cytochrome c oxidase, its function is JS278_02097 ENOG4105BZ9 Cytochrome C oxidase, subunit I JS278_02098 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) JS278_02107 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) JS278_02108 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein JS278_02111 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) JS278_02113 ENOG4105C5H ABC transporter JS278_02115 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN JS278_02116 ENOG4105JNK Glycosyl transferase (Group 1 JS278_02119 ENOG4105C5F glutamine synthetase JS278_02122 ENOG4105EGD dinuclear metal center protein, YbgI family JS278_02124 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) JS278_02126 ENOG4105C5F glutamine synthetase JS278_02134 ENOG4105WH1 Two component transcriptional regulator luxr family JS278_02136 ENOG4105D7N magnesium and cobalt transport protein CorA JS278_02140 ENOG4105CUB amino acid JS278_02144 ENOG4107T6F Xaa-Pro aminopeptidase JS278_02151 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) JS278_02152 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) JS278_02155 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) JS278_02156 ENOG4107QPH glycogen) synthase JS278_02160 ENOG4107R4C succinyl-diaminopimelate desuccinylase JS278_02161 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) JS278_02165 ENOG4108Z4U Ferredoxin JS278_02167 ENOG4107S1E Beta-lactamase JS278_02168 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) JS278_02169 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) JS278_02176 ENOG4105EF1 ribulokinase JS278_02179 ENOG4105D4U had-superfamily hydrolase, subfamily iia JS278_02181 ENOG4107YVI ribose 5-phosphate isomerase JS278_02182 ENOG4105E98 transcriptional regulator DeoR family JS278_02183 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) JS278_02184 ENOG4105CMT Dihydroxyacetone kinase JS278_02185 ENOG4105CPQ Dehydrogenase JS278_02186 ENOG4105C26 Dehydrogenase JS278_02190 ENOG4105DIK (ABC) transporter JS278_02191 ENOG4105CC5 ABC transporter JS278_02197 ENOG4105E5Q amino acid AbC transporter JS278_02201 ENOG410848D S4 domain protein YaaA JS278_02203 ENOG4105D5P Methylmalonyl-coA mutase JS278_02204 ENOG4105CMN Methylmalonyl-coA mutase JS278_02207 ENOG4108IUK alpha amylase, catalytic JS278_02208 ENOG4108IQI permease JS278_02209 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) JS278_02210 ENOG4105CPC Aldo Keto reductase JS278_02212 ENOG4105RH4 Glycine cleavage system transcriptional repressor JS278_02219 ENOG4105CSH Transporter JS278_02220 ENOG4105CSH Transporter JS278_02221 ENOG4108JA1 polyketide synthase JS278_02222 ENOG4107QP6 Xylose isomerase domain protein TIM barrel JS278_02223 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) JS278_02224 ENOG4105ETE Transcriptional regulator (LacI family JS278_02228 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) JS278_02232 ENOG4108ZM9 phosphoglycerate mutase JS278_02233 ENOG4105BZ1 (ABC) transporter JS278_02236 ENOG4105FQP Beta-lactamase JS278_02254 ENOG4105VDM plasmid maintenance system antidote protein, xre family JS278_02256 ENOG4105VDM plasmid maintenance system antidote protein, xre family JS278_02259 ENOG4105C3G gtp-binding protein JS278_02262 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) JS278_02263 ENOG4105DFM M18 family aminopeptidase JS278_02265 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) JS278_02266 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) JS278_02267 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) JS278_02269 ENOG4108IAB Phoh family JS278_02271 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) JS278_02272 ENOG4105C7Z Conserved Protein JS278_02276 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) JS278_02279 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) JS278_02280 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) JS278_02287 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) JS278_02290 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) JS278_02291 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) JS278_02292 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) JS278_02294 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase JS278_02295 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) JS278_02296 ENOG41084BS 50S ribosomal protein L35 JS278_02297 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) JS278_02305 ENOG4105CUB amino acid JS278_02306 ENOG4106V2I dimethylaminohydrolase JS278_02310 ENOG4105EZR dyp-type peroxidase family protein JS278_02319 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) JS278_02324 ENOG4105F5W AtP-binding protein JS278_02325 ENOG4105D70 Integrase catalytic subunit JS278_02326 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) JS278_02327 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) JS278_02328 ENOG4105C5T Phosphoribosyl pyrophosphate synthase JS278_02329 ENOG4107U1N Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) JS278_02332 ENOG41082F9 transcriptional regulator JS278_02333 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) JS278_02334 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) JS278_02335 ENOG4105F8V Hydrolase, tatD family JS278_02338 ENOG4105C2W permease JS278_02340 ENOG4105P4J Allophanate hydrolase, subunit 1 JS278_02341 ENOG4105E7W lamb ycsf family protein JS278_02348 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) JS278_02351 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase JS278_02353 ENOG4108Z0Z intracellular protease Pfpi family JS278_02361 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein JS278_02365 ENOG4105D9R oxidoreductase JS278_02369 ENOG4105C0D helicase JS278_02372 ENOG4105CHM Aminotransferase JS278_02378 ENOG4105D9U N-acetyltransferase JS278_02380 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase JS278_02383 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) JS278_02388 ENOG4105C54 Major Facilitator superfamily JS278_02389 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) JS278_02390 ENOG4105ETE Transcriptional regulator (LacI family JS278_02391 ENOG4105C54 Major Facilitator superfamily JS278_02392 ENOG4105ETE Transcriptional regulator (LacI family JS278_02394 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) JS278_02395 ENOG4105DH8 myo-inositol catabolism JS278_02397 ENOG4105D7K pfkb domain protein JS278_02398 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) JS278_02401 ENOG4107R5H iron (metal) dependent repressor, dtxr family JS278_02402 ENOG4105CE4 GlcNAc 6-P deacetylase JS278_02403 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) JS278_02406 ENOG4105C7N Xanthine uracil vitamin C permease JS278_02410 ENOG4105VEQ Cold shock protein JS278_02411 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) JS278_02416 ENOG4106N3A copper homeostasis protein cutc JS278_02422 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) JS278_02424 ENOG4105EIP mannose-6-phosphate isomerase JS278_02425 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) JS278_02429 ENOG4105KRQ Addiction module toxin, Txe YoeB family JS278_02430 ENOG41084HI prevent-host-death family JS278_02435 ENOG4108YZT Adenosylcobinamide kinase JS278_02436 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) JS278_02438 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) JS278_02439 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) JS278_02440 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase JS278_02441 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase JS278_02442 ENOG4108JJB ABC transporter JS278_02443 ENOG4108V4M Cobalt abc transporter JS278_02444 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) JS278_02445 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) JS278_02448 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) JS278_02449 ENOG4105E4R Precorrin-3B C17-methyltransferase JS278_02450 ENOG4105CIA precorrin-4 C(11)-methyltransferase JS278_02452 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) JS278_02453 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) JS278_02455 ENOG4105WH1 Two component transcriptional regulator luxr family JS278_02456 ENOG4105ENE Histidine kinase JS278_02457 ENOG4105CJ1 ABC, transporter JS278_02461 ENOG4105CVJ phosphoglycerate mutase JS278_02462 ENOG4105EEI dihydropteroate synthase JS278_02463 ENOG4108S01 response regulator JS278_02464 ENOG4108ZGX Histidine kinase JS278_02466 ENOG4108M15 ABC transporter JS278_02467 ENOG4108UVJ appr-1-p processing domain protein JS278_02469 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) JS278_02470 ENOG4105CPQ Dehydrogenase JS278_02471 ENOG4105DRS transport system, permease JS278_02472 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component JS278_02474 ENOG4105DKQ ROK family JS278_02475 ENOG4105EJQ L-serine dehydratase JS278_02482 ENOG4105C28 cystathionine JS278_02485 ENOG4105C8N cysteinyl-tRNA synthetase JS278_02488 ENOG4105EQ0 Major Facilitator superfamily JS278_02489 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) JS278_02495 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) JS278_02496 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) JS278_02501 ENOG4108JQ1 Dehydrogenase JS278_02502 ENOG4105CPQ Dehydrogenase JS278_02506 ENOG4105DZY Pts system, glucitol sorbitol-specific JS278_02509 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase JS278_02512 ENOG4108VJ1 Transcriptional regulator (CarD family JS278_02515 ENOG4105BZU Histidine kinase JS278_02516 ENOG4108UTW Plays a role in the regulation of phosphate uptake JS278_02517 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) JS278_02518 ENOG410849S phosphocarrier protein (HPr) JS278_02519 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) JS278_02521 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein JS278_02522 ENOG4107QX3 carboxylase JS278_02523 ENOG4107QX3 carboxylase JS278_02524 ENOG4107QSA Oxaloacetate decarboxylase JS278_02525 ENOG4107RCW fructose-bisphosphate aldolase JS278_02528 ENOG4105DQR SNARE associated Golgi JS278_02530 ENOG4107MM9 BNR Asp-box repeat-containing protein JS278_02532 ENOG4107YJ4 chain length determinant protein JS278_02538 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) JS278_02542 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) JS278_02543 ENOG4108V0P LemA family JS278_02547 ENOG4105CHM Aminotransferase JS278_02550 ENOG4108HQS Glycine betaine JS278_02551 ENOG4108IJ7 Glycine betaine JS278_02552 ENOG4105K5B UPF0225 protein JS278_02557 ENOG4105CVR type I restriction-modification system JS278_02559 ENOG4105DZR Type I site-specific deoxyribonuclease JS278_02565 ENOG4105ETE Transcriptional regulator (LacI family JS278_02566 ENOG4107FKK extracellular solute-binding protein family 1 JS278_02567 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component JS278_02568 ENOG4105DRS transport system, permease JS278_02571 ENOG4105ECR NmrA family JS278_02574 ENOG4105ECB domain protein JS278_02577 ENOG4105F8D glycoside hydrolase family 4 JS278_02578 ENOG4105E98 transcriptional regulator DeoR family JS278_02579 ENOG4105EDK PfkB domain protein JS278_02582 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component JS278_02583 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component JS278_02584 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit JS278_02586 ENOG4105WYW fructose-bisphosphate aldolase JS278_02591 ENOG4105BZU Histidine kinase JS278_02592 ENOG4105WH1 Two component transcriptional regulator luxr family JS278_02596 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) JS278_02597 ENOG4105C85 amino acid JS278_02598 ENOG4107WGA YidE YbjL JS278_02599 ENOG4107FQX Alpha-acetolactate decarboxylase JS278_02600 ENOG4105CPQ Dehydrogenase JS278_02601 ENOG4105KNI merR family transcriptional Regulator JS278_02602 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) JS278_02603 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ JS278_02604 ENOG4105CFG Acts as a chaperone (By similarity) JS278_02605 ENOG4108IJ8 ABC transporter JS278_02608 ENOG4108ZHJ Organic hydroperoxide resistance protein JS278_02610 ENOG4105MSY salicylate hydroxylase JS278_02612 ENOG4107YPT transcriptional regulator JS278_02613 ENOG4108IXY short-chain dehydrogenase reductase JS278_02616 ENOG4105CK6 Two component transcriptional regulator (Winged helix family JS278_02617 ENOG4105BZU Histidine kinase JS278_02618 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) JS278_02621 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) JS278_02623 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) JS278_02624 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) JS278_02625 ENOG4105EAC phosphoserine phosphatase JS278_02626 ENOG4105DSB aldose 1-epimerase JS278_02630 ENOG4105CJ1 ABC, transporter JS278_02633 ENOG4108JQ7 (ABC) transporter JS278_02637 ENOG4105II7 pyrroline-5-carboxylate reductase JS278_02638 ENOG4108IJ0 Aspartate ammonia-lyase JS278_02639 ENOG4105CI2 imidazolone-5-propionate hydrolase JS278_02647 ENOG4107SET aldo keto reductase JS278_02653 ENOG4105DFK Polyphosphate glucokinase JS278_02654 ENOG4105C75 arginyL-tRNA synthetase JS278_02656 ENOG4105IE8 Alpha-ketoglutarate permease JS278_02659 ENOG4108UB4 uncharacterized protein ygjQ JS278_02660 ENOG4107QP8 phosphohexose isomerase JS278_02662 ENOG4105CQR helicase JS278_02664 ENOG4108V1U phospholipid-binding protein JS278_02668 ENOG4108FN7 Aldo keto reductase JS278_02670 ENOG41083TI Protein CrcB homolog JS278_02671 ENOG41085J0 Protein CrcB homolog JS278_02673 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) JS278_02677 ENOG4105D94 Major Facilitator Superfamily JS278_02681 ENOG4105CFH Aspartokinase JS278_02686 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) JS278_02688 ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A JS278_02689 ENOG4108HCJ Hydrolase JS278_02690 ENOG410667J hydrolase JS278_02696 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) JS278_02697 ENOG41087ID Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) JS278_02704 ENOG4105DIM ABC transporter JS278_02705 ENOG4105CIG ABC transporter JS278_02707 ENOG4105C85 amino acid JS278_02711 ENOG4105CSH Transporter JS278_02717 ENOG4105VT3 DNA binding domain protein, excisionase family JS278_02724 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) JS278_02727 ENOG4107YJ4 chain length determinant protein JS278_02731 ENOG4108KGH TRANSCRIPTIONal JS278_02734 ENOG4105D3Q Sugar transferase JS278_02735 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein JS278_02737 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) JS278_02738 ENOG4105C1B dTDP-glucose 4-6-dehydratase JS278_02740 ENOG4105TV9 FHA Domain-Containing protein JS278_02741 ENOG4105HZM Fha domain containing protein JS278_02744 ENOG4105CJN penicillin-binding protein JS278_02748 ENOG4105ZJT Cell division protein CrgA JS278_02750 ENOG4105K8R UPF0145 protein JS278_02752 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease JS278_02754 ENOG4105C5R Aminotransferase JS278_02758 ENOG4107YCY Transcriptional regulator JS278_02759 ENOG4107R1Q Membrane protein FdrA JS278_02760 ENOG4107REC cytoplasmic protein JS278_02762 ENOG4105C5B carbamate kinase JS278_02765 ENOG4107VXZ Hydrolase JS278_02769 ENOG4105ETE Transcriptional regulator (LacI family JS278_02770 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component JS278_02771 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component JS278_02772 ENOG4105XN3 extracellular solute-binding protein family 1 JS278_02774 ENOG4108JB8 alcohol dehydrogenase JS278_02775 ENOG4105C0R drug resistance transporter emrb qaca subfamily JS278_02784 ENOG4105C4M (Ubiquinol oxidase) subunit I JS278_02785 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii JS278_02786 ENOG4108JJ9 ABC, transporter JS278_02787 ENOG4108JJ8 (ABC) transporter JS278_02789 ENOG41080R8 Conserved Protein JS278_02791 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) JS278_02792 ENOG4105DAA L-lactate JS278_02793 ENOG41073TP transcriptional regulator JS278_02795 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) JS278_02796 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) JS278_02798 ENOG4105K6T rare lipoprotein A JS278_02801 ENOG4105VPX protein, conserved in bacteria JS278_02802 ENOG4105CDU Replicative dna helicase JS278_02803 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) JS278_02809 ENOG4105K63 Thioredoxin JS278_02810 ENOG4105C3M thioredoxin reductase JS278_02811 ENOG4108V06 Glutathione peroxidase JS278_02816 ENOG4108VX5 3-methyladenine DNA glycosylase JS278_02818 ENOG4105CQ7 ATP-dependent helicase JS278_02821 ENOG4105KHC sulfurtransferase JS278_02829 ENOG4105CKK Glycosyl transferase, family 2 JS278_02831 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase JS278_02834 ENOG4108IJ1 Dehydrogenase JS278_02835 ENOG4105CDA abc transporter atp-binding protein JS278_02836 ENOG4107UBR Extracellular solute-binding protein family 3 JS278_02837 ENOG4108Q1T ABC transporter JS278_02838 ENOG4105DRP amino acid AbC transporter JS278_02839 ENOG4105E98 transcriptional regulator DeoR family JS278_02843 ENOG4105DM4 PTS System JS278_02850 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) JS278_02852 ENOG4105CPK Glycosyl transferase (Group 1 JS278_02853 ENOG4108QV3 biosynthesis protein JS278_02858 ENOG4107T8Q Glycosyl transferase (Group 1 JS278_02859 ENOG4107T8Q Glycosyl transferase (Group 1 JS278_02862 ENOG4105CKK Glycosyl transferase, family 2 JS278_02866 ENOG4105BZ4 penicillin-binding protein JS278_02871 ENOG4105CMM transposase JS278_02874 ENOG4108IG5 Transcriptional regulator JS278_02876 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein JS278_02880 ENOG4105MP0 transposase JS278_02884 ENOG4106F59 XRE family Transcriptional regulator JS278_02886 ENOG4108RFG Tetr family transcriptional regulator JS278_02888 ENOG4105MSB protein, conserved in bacteria JS278_02889 ENOG4105CPQ Dehydrogenase JS278_02898 ENOG4105F95 Monooxygenase JS278_02901 ENOG4108Z7F N-acetyltransferase JS278_02903 ENOG4105C37 (CBS) domain JS278_02909 ENOG4105CV1 Transketolase (EC 2.2.1.1) JS278_02913 ENOG4105CPQ Dehydrogenase JS278_02917 ENOG4105DKW ABC transporter JS278_02920 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase JS278_02921 ENOG4105CEE C4-dicarboxylate transporter JS278_02924 ENOG4105D1H recombination factor protein RarA JS278_02928 ENOG4105ETE Transcriptional regulator (LacI family JS278_02930 ENOG4107QNK )-transporter JS278_02932 ENOG4105ETE Transcriptional regulator (LacI family JS278_02933 ENOG4105ETE Transcriptional regulator (LacI family JS278_02934 ENOG4105C2J ABC transporter JS278_02935 ENOG4105CNN ABC, transporter JS278_02938 ENOG4105MP0 transposase JS278_02950 ENOG4107HQ7 repeat protein JS278_02951 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family JS278_02952 ENOG4105EQN UPF0261 protein JS278_02956 ENOG4105EIP mannose-6-phosphate isomerase JS278_02957 ENOG4107Y80 Major Facilitator superfamily JS278_02971 ENOG4106F1P AAA ATPase, central domain protein JS278_02973 ENOG4106F59 XRE family Transcriptional regulator JS278_02974 ENOG4105XUP Phage derived protein Gp49-like (DUF891) JS278_02978 ENOG4107QRT dEAD DEAH box helicase JS278_02980 ENOG4105C0D helicase JS278_02991 ENOG4105ETE Transcriptional regulator (LacI family JS278_02994 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component JS278_02995 ENOG4105I1K ABC transporter JS278_02996 ENOG4107VXM glycerophosphoryl diester phosphodiesterase JS278_02997 ENOG4105ETE Transcriptional regulator (LacI family JS278_02999 ENOG4105KT7 mgtC SapB transporter JS278_03001 ENOG4105DZW Dipeptidase JS278_03006 ENOG4105ETE Transcriptional regulator (LacI family JS278_03007 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator JS278_03008 ENOG4105C2J ABC transporter JS278_03009 ENOG4107R9N ABC transporter JS278_03010 ENOG41062B0 ABC transporter, permease JS278_03013 ENOG4107QNK )-transporter JS278_03016 ENOG41060NJ transcriptional regulator JS278_03017 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis JS278_03018 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) JS278_03019 ENOG4105DWF phosphomethylpyrimidine kinase JS278_03020 ENOG4105CB5 ATP-dependent DNA helicase recG JS278_03021 ENOG4108VW9 Membrane JS278_03022 ENOG4105CH6 catalase JS278_03023 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) JS278_03024 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) JS278_03027 ENOG4108ZAF Molybdopterin JS278_03029 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) JS278_03033 ENOG4108IUE nitrate reductase beta subunit JS278_03036 ENOG4105YES addiction module antidote protein JS278_03037 ENOG4106A3M Cytochrome p-450 JS278_03038 ENOG4108SQ9 flavin reductase domain protein, FMN-binding JS278_03047 ENOG4105F4R Transcriptional regulator mode JS278_03052 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component JS278_03055 ENOG4105CHF Glutathione S-transferase JS278_03057 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) JS278_03061 ENOG4105DS0 Transcriptional regulator, Crp Fnr family JS278_03063 ENOG4105C59 p-type ATPase JS278_03070 ENOG4105CTQ phosphohexokinase JS278_03074 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) JS278_03084 ENOG4105CD5 CoA-binding domain protein JS278_03085 ENOG41086YM Acylphosphatase JS278_03089 ENOG4105C6K Malic enzyme JS278_03090 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) JS278_03091 ENOG4105C0R drug resistance transporter emrb qaca subfamily JS278_03094 ENOG4105C2C drug resistance transporter, Bcr CflA JS278_03096 ENOG4105WH1 Two component transcriptional regulator luxr family JS278_03102 ENOG4105K63 Thioredoxin JS278_03105 ENOG4108XG2 Histidine kinase JS278_03113 ENOG4105F9F transposase JS278_03114 ENOG4107QP6 Xylose isomerase domain protein TIM barrel JS278_03115 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) JS278_03116 ENOG4105ETE Transcriptional regulator (LacI family JS278_03120 ENOG4105DXI Major Facilitator superfamily JS278_03122 ENOG4107ZR7 Membrane JS278_03124 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) JS278_03127 ENOG4107QNK )-transporter JS278_03128 ENOG4107QNK )-transporter JS278_03129 ENOG4105ETE Transcriptional regulator (LacI family JS278_03130 ENOG4107QNK )-transporter JS278_03133 ENOG4105F0H myo-inositol catabolism protein JS278_03134 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) JS278_03136 ENOG4105C26 Dehydrogenase JS278_03137 ENOG4105FDP GntR family transcriptional regulator JS278_03139 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family JS278_03140 ENOG4105CPF Cell wall formation (By similarity) JS278_03143 ENOG4105DQE DNA ligase JS278_03145 ENOG4107QJE Chromosome Partitioning Protein JS278_03146 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) JS278_03147 ENOG4105KPY Small multidrug resistance protein JS278_03149 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins JS278_03150 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) JS278_03151 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)