locus-tag	class	description
JS278_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JS278_00003	COG0577	efflux transmembrane transporter activity
JS278_00004	COG0592	DNA-directed DNA polymerase activity
JS278_00006	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JS278_00007	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
JS278_00009	COG0187	DNA topoisomerase II activity
JS278_00010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JS278_00014	COG1609	Transcriptional regulator
JS278_00015	COG1129	ABC transporter
JS278_00016	COG1172	Belongs to the binding-protein-dependent transport system permease family
JS278_00017	COG1879	ABC-type sugar transport system periplasmic component
JS278_00018	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS278_00019	COG1869	D-ribose catabolic process
JS278_00024	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_00027	COG1396	sequence-specific DNA binding
JS278_00028	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
JS278_00031	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JS278_00036	COG0281	malic enzyme
JS278_00037	COG0039	L-malate dehydrogenase activity
JS278_00038	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
JS278_00042	COG4106	trans-aconitate 2-methyltransferase activity
JS278_00043	COG4106	trans-aconitate 2-methyltransferase activity
JS278_00045	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JS278_00046	COG4139	cobalamin transport
JS278_00047	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JS278_00048	COG2197	response regulator
JS278_00054	COG0235	Class ii aldolase
JS278_00056	COG1063	alcohol dehydrogenase
JS278_00057	COG3414	Phosphotransferase system galactitol-specific IIB component
JS278_00058	COG3775	system Galactitol-specific IIC component
JS278_00061	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JS278_00064	COG1131	(ABC) transporter
JS278_00066	COG0095	Lipoate-protein ligase
JS278_00067	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JS278_00068	COG0765	amino acid transport
JS278_00069	COG1126	abc transporter atp-binding protein
JS278_00070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JS278_00073	COG1175	transmembrane transport
JS278_00074	COG3833	ABC-type maltose transport systems, permease component
JS278_00089	COG1012	belongs to the aldehyde dehydrogenase family
JS278_00095	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JS278_00097	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JS278_00102	COG2177	Part of the ABC transporter FtsEX involved in
JS278_00103	COG0577	efflux transmembrane transporter activity
JS278_00103	COG1136	(ABC) transporter
JS278_00104	COG2197	response regulator
JS278_00105	COG1690	Belongs to the RtcB family
JS278_00109	COG0477	Major facilitator Superfamily
JS278_00110	COG2826	transposase and inactivated derivatives, IS30 family
JS278_00113	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JS278_00115	COG2205	protein histidine kinase activity
JS278_00116	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JS278_00117	COG4585	Histidine kinase
JS278_00122	COG0175	sulfate reduction
JS278_00125	COG0730	response to heat
JS278_00130	COG1473	amidohydrolase
JS278_00132	COG0656	L-ascorbic acid biosynthetic process
JS278_00133	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JS278_00134	COG0596	Alpha beta hydrolase
JS278_00134	COG0508	dehydrogenase complex catalyzes the overall conversion of
JS278_00136	COG2022	thiamine diphosphate biosynthetic process
JS278_00139	COG1428	Deoxynucleoside kinase
JS278_00140	COG1309	transcriptional regulator
JS278_00141	COG2409	Drug exporters of the RND superfamily
JS278_00143	COG2910	NAD(P)H-binding
JS278_00144	COG1733	regulation of RNA biosynthetic process
JS278_00145	COG0492	ferredoxin-NADP+ reductase activity
JS278_00145	COG3118	belongs to the thioredoxin family
JS278_00150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JS278_00151	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JS278_00154	COG1595	DNA-templated transcription, initiation
JS278_00155	COG0515	serine threonine protein kinase
JS278_00155	COG2815	serine threonine protein kinase
JS278_00159	COG0385	Bile acid
JS278_00160	COG1012	belongs to the aldehyde dehydrogenase family
JS278_00161	COG0617	tRNA 3'-terminal CCA addition
JS278_00162	COG1929	Belongs to the glycerate kinase type-1 family
JS278_00164	COG0668	transmembrane transport
JS278_00166	COG0540	Belongs to the ATCase OTCase family
JS278_00170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JS278_00172	COG0114	fumarate hydratase activity
JS278_00181	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JS278_00185	COG0745	RESPONSE REGULATOR receiver
JS278_00188	COG2205	protein histidine kinase activity
JS278_00189	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JS278_00191	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JS278_00200	COG2267	carboxylic ester hydrolase activity
JS278_00201	COG0686	Belongs to the AlaDH PNT family
JS278_00203	COG1012	belongs to the aldehyde dehydrogenase family
JS278_00206	COG0515	serine threonine protein kinase
JS278_00207	COG1716	ATPase activity
JS278_00207	COG0842	Transport permease protein
JS278_00207	COG1131	(ABC) transporter
JS278_00208	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JS278_00208	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JS278_00210	COG2002	toxin-antitoxin pair type II binding
JS278_00211	COG3609	addiction module antidote protein, CC2985 family
JS278_00212	COG2337	Toxic component of a toxin-antitoxin (TA) module
JS278_00219	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_00221	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JS278_00225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JS278_00226	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JS278_00231	COG1175	transmembrane transport
JS278_00233	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JS278_00234	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS278_00255	COG1113	amino acid transport
JS278_00257	COG1846	Transcriptional regulator
JS278_00262	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JS278_00265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JS278_00266	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
JS278_00267	COG0247	lactate metabolic process
JS278_00275	COG1131	(ABC) transporter
JS278_00277	COG2197	response regulator
JS278_00278	COG4585	Histidine kinase
JS278_00282	COG0277	FAD linked oxidase domain protein
JS278_00291	COG0300	oxidoreductase activity
JS278_00293	COG1022	Amp-dependent synthetase and ligase
JS278_00299	COG0672	)-iron permease
JS278_00301	COG2837	iron assimilation
JS278_00302	COG0360	Binds together with S18 to 16S ribosomal RNA
JS278_00304	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JS278_00305	COG0359	binds to the 23S rRNA
JS278_00307	COG1968	undecaprenyl-diphosphatase activity
JS278_00309	COG1902	pentaerythritol trinitrate reductase activity
JS278_00314	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JS278_00316	COG2205	protein histidine kinase activity
JS278_00320	COG1132	(ABC) transporter
JS278_00321	COG1132	(ABC) transporter
JS278_00323	COG0737	Belongs to the 5'-nucleotidase family
JS278_00324	COG0366	Alpha amylase catalytic
JS278_00325	COG0395	ABC-type sugar transport system, permease component
JS278_00333	COG1285	pathogenesis
JS278_00335	COG1175	transmembrane transport
JS278_00336	COG0395	ABC-type sugar transport system, permease component
JS278_00344	COG1609	Transcriptional regulator
JS278_00346	COG1175	transmembrane transport
JS278_00349	COG1609	Transcriptional regulator
JS278_00351	COG1175	transmembrane transport
JS278_00352	COG0395	ABC-type sugar transport system, permease component
JS278_00357	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
JS278_00357	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
JS278_00365	COG0531	amino acid
JS278_00367	COG1113	amino acid transport
JS278_00368	COG0686	Belongs to the AlaDH PNT family
JS278_00385	COG0535	radical SAM domain protein
JS278_00388	COG0022	dehydrogenase e1 component
JS278_00389	COG0508	dehydrogenase complex catalyzes the overall conversion of
JS278_00391	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JS278_00393	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JS278_00396	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JS278_00399	COG3833	ABC-type maltose transport systems, permease component
JS278_00402	COG1609	Transcriptional regulator
JS278_00403	COG0561	phosphatase activity
JS278_00408	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_00408	COG3321	synthase
JS278_00408	COG0604	alcohol dehydrogenase
JS278_00413	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JS278_00420	COG0584	glycerophosphoryl diester phosphodiesterase
JS278_00421	COG0823	Involved in the tonB-independent uptake of proteins
JS278_00421	COG1506	peptidase
JS278_00421	COG4946	Tricorn protease homolog
JS278_00422	COG2130	NADP-dependent
JS278_00426	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JS278_00428	COG0590	tRNA wobble adenosine to inosine editing
JS278_00436	COG1174	glycine betaine transport
JS278_00439	COG3263	regulation of cellular component size
JS278_00447	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JS278_00450	COG2188	Transcriptional regulator
JS278_00454	COG1942	4-Oxalocrotonate Tautomerase
JS278_00455	COG0673	inositol 2-dehydrogenase activity
JS278_00457	COG1946	Acyl-CoA thioesterase
JS278_00461	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JS278_00463	COG3716	PTS system mannose fructose sorbose family IID component
JS278_00464	COG3715	PTS system
JS278_00465	COG2188	Transcriptional regulator
JS278_00468	COG2376	Dihydroxyacetone kinase
JS278_00470	COG1609	Transcriptional regulator
JS278_00471	COG0395	ABC-type sugar transport system, permease component
JS278_00472	COG1175	transmembrane transport
JS278_00476	COG3340	Belongs to the peptidase S51 family
JS278_00477	COG1414	Transcriptional regulator
JS278_00479	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JS278_00480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JS278_00481	COG2390	Transcriptional regulator
JS278_00482	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JS278_00485	COG0235	Class ii aldolase
JS278_00486	COG0656	L-ascorbic acid biosynthetic process
JS278_00487	COG1830	Aldolase
JS278_00488	COG1063	alcohol dehydrogenase
JS278_00490	COG0445	tRNA wobble uridine modification
JS278_00491	COG2271	Major facilitator Superfamily
JS278_00492	COG1349	DNA-binding transcription factor activity
JS278_00495	COG1501	Belongs to the glycosyl hydrolase 31 family
JS278_00498	COG3684	Belongs to the aldolase LacD family
JS278_00499	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS278_00503	COG1518	maintenance of DNA repeat elements
JS278_00503	COG1468	defense response to virus
JS278_00511	COG4572	Cation transport regulator
JS278_00514	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_00516	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JS278_00517	COG0783	Belongs to the Dps family
JS278_00519	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_00527	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JS278_00527	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JS278_00530	COG2124	cytochrome p450
JS278_00534	COG1295	ribonuclease BN
JS278_00541	COG0534	Mate efflux family protein
JS278_00545	COG4942	peptidase
JS278_00546	COG3177	Filamentation induced by cAMP protein fic
JS278_00548	COG2826	transposase and inactivated derivatives, IS30 family
JS278_00550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JS278_00553	COG1072	(Pantothenic acid kinase))
JS278_00554	COG1069	ribulokinase activity
JS278_00556	COG0254	rRNA binding
JS278_00557	COG3022	response to hydroperoxide
JS278_00559	COG4608	Belongs to the ABC transporter superfamily
JS278_00561	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JS278_00562	COG0601	transmembrane transport
JS278_00568	COG1846	Transcriptional regulator
JS278_00569	COG2040	homocysteine
JS278_00570	COG0833	amino acid
JS278_00577	COG1408	metallophosphoesterase
JS278_00578	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JS278_00579	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JS278_00586	COG0494	nUDIX hydrolase
JS278_00610	COG2026	Addiction module toxin, RelE StbE family
JS278_00611	COG1205	dead DEAH box helicase
JS278_00611	COG1111	helicase
JS278_00612	COG2890	protein-(glutamine-N5) methyltransferase activity
JS278_00614	COG1754	DNA topoisomerase type I activity
JS278_00614	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JS278_00616	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JS278_00617	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JS278_00619	COG1774	PSP1 C-terminal conserved region
JS278_00624	COG4115	mRNA cleavage
JS278_00625	COG2161	toxin-antitoxin pair type II binding
JS278_00629	COG1231	oxidoreductase activity
JS278_00630	COG0431	NADPH-dependent FMN reductase
JS278_00631	COG0519	Catalyzes the synthesis of GMP from XMP
JS278_00631	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JS278_00635	COG0601	transmembrane transport
JS278_00636	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JS278_00638	COG1619	proteins homologs of microcin C7 resistance protein MccF
JS278_00650	COG3458	cephalosporin-C deacetylase activity
JS278_00652	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JS278_00654	COG0037	tRNA processing
JS278_00657	COG0302	gtp cyclohydrolase
JS278_00660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JS278_00662	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JS278_00665	COG0649	NAD binding
JS278_00667	COG0542	response to heat
JS278_00670	COG0270	DNA (cytosine-5-)-methyltransferase activity
JS278_00686	COG0457	Tetratricopeptide repeat
JS278_00686	COG0705	Rhomboid family
JS278_00688	COG4143	(ABC) transporter
JS278_00690	COG3842	ATPase activity
JS278_00694	COG1194	a g-specific adenine glycosylase
JS278_00695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JS278_00696	COG0113	porphobilinogen synthase activity
JS278_00698	COG0181	hydroxymethylbilane synthase activity
JS278_00700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JS278_00701	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JS278_00704	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
JS278_00705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JS278_00707	COG1082	Xylose isomerase domain protein TIM barrel
JS278_00711	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JS278_00712	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JS278_00713	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JS278_00713	COG1648	precorrin-2 dehydrogenase activity
JS278_00714	COG0406	alpha-ribazole phosphatase activity
JS278_00715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JS278_00716	COG0785	Cytochrome C biogenesis protein
JS278_00718	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JS278_00722	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JS278_00724	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JS278_00725	COG0129	dihydroxy-acid dehydratase activity
JS278_00729	COG1120	ATPase activity
JS278_00730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JS278_00731	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JS278_00732	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JS278_00733	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JS278_00734	COG0581	inorganic phosphate transmembrane transporter activity
JS278_00738	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JS278_00739	COG0745	RESPONSE REGULATOR receiver
JS278_00743	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JS278_00745	COG1490	D-aminoacyl-tRNA deacylase activity
JS278_00748	COG3485	protocatechuate 3,4-dioxygenase
JS278_00750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JS278_00756	COG1937	Protein conserved in bacteria
JS278_00759	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JS278_00762	COG4423	Transcription factor
JS278_00764	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JS278_00765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JS278_00766	COG0047	phosphoribosylformylglycinamidine synthase activity
JS278_00767	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JS278_00768	COG1113	amino acid transport
JS278_00769	COG0252	asparaginase activity
JS278_00771	COG1703	isobutyryl-CoA mutase activity
JS278_00772	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JS278_00780	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JS278_00785	COG0395	ABC-type sugar transport system, permease component
JS278_00809	COG1196	nuclear chromosome segregation
JS278_00809	COG0741	lytic transglycosylase activity
JS278_00809	COG0739	heme binding
JS278_00830	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_00833	COG0477	Major facilitator Superfamily
JS278_00835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JS278_00844	COG2084	Dehydrogenase
JS278_00847	COG0574	Belongs to the PEP-utilizing enzyme family
JS278_00847	COG3848	Pyruvate phosphate dikinase
JS278_00854	COG1304	FMN binding
JS278_00857	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JS278_00858	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JS278_00861	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JS278_00866	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JS278_00869	COG0590	tRNA wobble adenosine to inosine editing
JS278_00870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JS278_00870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS278_00870	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JS278_00871	COG1461	Dihydroxyacetone kinase
JS278_00872	COG2376	Dihydroxyacetone kinase
JS278_00876	COG1132	(ABC) transporter
JS278_00878	COG2226	methyltransferase
JS278_00884	COG0644	oxidoreductase
JS278_00886	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JS278_00887	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JS278_00888	COG0649	NAD binding
JS278_00890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JS278_00891	COG1034	ATP synthesis coupled electron transport
JS278_00892	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JS278_00893	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JS278_00895	COG0713	ATP synthesis coupled electron transport
JS278_00898	COG1007	ATP synthesis coupled electron transport
JS278_00901	COG3590	peptidase
JS278_00902	COG1013	pyruvate-flavodoxin oxidoreductase activity
JS278_00903	COG0674	pyruvate-flavodoxin oxidoreductase activity
JS278_00903	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JS278_00904	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JS278_00906	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JS278_00914	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JS278_00915	COG2030	dehydratase
JS278_00917	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JS278_00918	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JS278_00921	COG0250	Participates in transcription elongation, termination and antitermination
JS278_00922	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JS278_00923	COG0081	regulation of translation
JS278_00924	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JS278_00925	COG0222	ribosome binding
JS278_00926	COG0085	RNA polymerase activity
JS278_00927	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JS278_00930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JS278_00931	COG0049	tRNA binding
JS278_00932	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JS278_00933	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JS278_00936	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JS278_00937	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JS278_00938	COG0051	transcription antitermination factor activity, RNA binding
JS278_00939	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JS278_00940	COG0088	Forms part of the polypeptide exit tunnel
JS278_00941	COG0089	rRNA binding
JS278_00942	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JS278_00943	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JS278_00944	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JS278_00945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JS278_00946	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JS278_00947	COG0255	Belongs to the universal ribosomal protein uL29 family
JS278_00948	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JS278_00950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JS278_00951	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JS278_00952	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JS278_00953	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JS278_00954	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JS278_00955	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JS278_00956	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JS278_00957	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JS278_00958	COG1841	ribosomal large subunit assembly
JS278_00959	COG0200	Binds to the 23S rRNA
JS278_00966	COG0563	adenylate kinase activity
JS278_00970	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JS278_00971	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JS278_00972	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JS278_00973	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JS278_00974	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JS278_00975	COG0202	RNA polymerase activity
JS278_00976	COG0203	ribosomal protein L17
JS278_00977	COG2826	transposase and inactivated derivatives, IS30 family
JS278_00980	COG0438	transferase activity, transferring glycosyl groups
JS278_00982	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JS278_00982	COG0519	Catalyzes the synthesis of GMP from XMP
JS278_00985	COG3845	ABC transporter
JS278_00989	COG0101	tRNA pseudouridine synthase activity
JS278_00990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JS278_00992	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JS278_00993	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JS278_00994	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_00995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JS278_00997	COG1072	(Pantothenic acid kinase))
JS278_00998	COG2226	methyltransferase
JS278_00999	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JS278_01000	COG0736	holo-[acyl-carrier-protein] synthase activity
JS278_01003	COG0513	Belongs to the DEAD box helicase family
JS278_01004	COG0802	atpase or kinase
JS278_01005	COG1214	PFAM Peptidase M22, glycoprotease
JS278_01005	COG0456	acetyltransferase
JS278_01007	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JS278_01011	COG1355	regulation of microtubule-based process
JS278_01015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JS278_01016	COG0459	protein refolding
JS278_01020	COG1605	Chorismate mutase
JS278_01020	COG0287	Prephenate dehydrogenase
JS278_01021	COG1045	serine acetyltransferase
JS278_01022	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JS278_01022	COG0519	Catalyzes the synthesis of GMP from XMP
JS278_01027	COG2197	response regulator
JS278_01028	COG2261	transglycosylase associated protein
JS278_01029	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JS278_01030	COG2011	ABC-type metal ion transport system permease component
JS278_01031	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JS278_01032	COG1464	Belongs to the NlpA lipoprotein family
JS278_01036	COG0045	succinate-CoA ligase (ADP-forming) activity
JS278_01042	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JS278_01042	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JS278_01043	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JS278_01045	COG0138	bifunctional purine biosynthesis protein purh
JS278_01047	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JS278_01050	COG0039	L-malate dehydrogenase activity
JS278_01054	COG1253	flavin adenine dinucleotide binding
JS278_01056	COG1744	ABC transporter substrate-binding protein PnrA-like
JS278_01064	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JS278_01067	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JS278_01071	COG4770	biotin carboxylase activity
JS278_01073	COG0351	phosphomethylpyrimidine kinase
JS278_01075	COG4221	oxidoreductase activity
JS278_01078	COG0424	maF-like protein
JS278_01080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JS278_01082	COG3340	Belongs to the peptidase S51 family
JS278_01086	COG1316	TRANSCRIPTIONal
JS278_01089	COG0662	Cupin 2, conserved barrel domain protein
JS278_01089	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
JS278_01098	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JS278_01099	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JS278_01105	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JS278_01108	COG1918	ferrous iron import across plasma membrane
JS278_01108	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
JS278_01110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JS278_01111	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JS278_01112	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JS278_01113	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JS278_01115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JS278_01116	COG2197	response regulator
JS278_01117	COG4585	Histidine kinase
JS278_01133	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JS278_01136	COG0587	DNA-directed DNA polymerase activity
JS278_01137	COG0531	amino acid
JS278_01143	COG1113	amino acid transport
JS278_01153	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JS278_01156	COG2818	Glycosylase
JS278_01159	COG0438	transferase activity, transferring glycosyl groups
JS278_01162	COG1733	regulation of RNA biosynthetic process
JS278_01168	COG1484	DNA-dependent DNA replication
JS278_01173	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JS278_01178	COG0277	FAD linked oxidase domain protein
JS278_01178	COG0247	lactate metabolic process
JS278_01181	COG1022	Amp-dependent synthetase and ligase
JS278_01187	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JS278_01190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JS278_01191	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JS278_01197	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JS278_01197	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JS278_01206	COG4974	Belongs to the 'phage' integrase family
JS278_01210	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_01212	COG0544	peptidyl-prolyl cis-trans isomerase activity
JS278_01213	COG0628	permease
JS278_01214	COG0740	serine-type endopeptidase activity
JS278_01215	COG0740	serine-type endopeptidase activity
JS278_01216	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JS278_01218	COG0793	Belongs to the peptidase S41A family
JS278_01218	COG4946	Tricorn protease homolog
JS278_01220	COG0525	valine-tRNA ligase activity
JS278_01222	COG0363	glucosamine-6-phosphate deaminase activity
JS278_01225	COG0109	protoheme IX farnesyltransferase activity
JS278_01228	COG1131	(ABC) transporter
JS278_01229	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
JS278_01230	COG1609	Transcriptional regulator
JS278_01231	COG3833	ABC-type maltose transport systems, permease component
JS278_01232	COG1175	transmembrane transport
JS278_01235	COG0719	Fe-S assembly protein
JS278_01238	COG0396	ATPase activity
JS278_01239	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JS278_01249	COG0488	(ABC) transporter
JS278_01255	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_01259	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JS278_01260	COG1119	ATPase activity
JS278_01274	COG0242	peptide deformylase activity
JS278_01277	COG4974	Belongs to the 'phage' integrase family
JS278_01280	COG3552	Protein containing von Willebrand factor type A (VWA) domain
JS278_01281	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JS278_01282	COG0714	Associated with various cellular activities
JS278_01283	COG3831	ATPase activity
JS278_01284	COG0052	Belongs to the universal ribosomal protein uS2 family
JS278_01285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JS278_01286	COG0528	UMP kinase activity
JS278_01287	COG0233	cytoplasmic translational termination
JS278_01288	COG0575	Belongs to the CDS family
JS278_01289	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JS278_01290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JS278_01292	COG0750	zinc metalloprotease
JS278_01294	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JS278_01297	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
JS278_01300	COG1305	Transglutaminase-like
JS278_01302	COG0442	prolyl-tRNA aminoacylation
JS278_01306	COG0779	Required for maturation of 30S ribosomal subunits
JS278_01308	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JS278_01309	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JS278_01310	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JS278_01311	COG0371	Dehydrogenase
JS278_01314	COG3732	PTS system glucitol sorbitol-specific
JS278_01318	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_01319	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JS278_01320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JS278_01322	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JS278_01323	COG1185	polyribonucleotide nucleotidyltransferase activity
JS278_01324	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JS278_01326	COG0028	Belongs to the TPP enzyme family
JS278_01328	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JS278_01329	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JS278_01332	COG0742	ribosomal rna small subunit methyltransferase
JS278_01333	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JS278_01335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JS278_01336	COG0571	ribonuclease III activity
JS278_01337	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JS278_01344	COG0228	four-way junction DNA binding
JS278_01345	COG1837	Belongs to the UPF0109 family
JS278_01346	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JS278_01347	COG0336	Belongs to the RNA methyltransferase TrmD family
JS278_01349	COG1053	succinate dehydrogenase
JS278_01350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JS278_01351	COG0335	large ribosomal subunit rRNA binding
JS278_01352	COG0681	Belongs to the peptidase S26 family
JS278_01353	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JS278_01355	COG0792	nuclease activity
JS278_01356	COG0606	chelatase, subunit chli
JS278_01361	COG1175	transmembrane transport
JS278_01362	COG0395	ABC-type sugar transport system, permease component
JS278_01363	COG1609	Transcriptional regulator
JS278_01368	COG2160	L-arabinose isomerase activity
JS278_01369	COG1609	Transcriptional regulator
JS278_01370	COG0673	inositol 2-dehydrogenase activity
JS278_01372	COG2814	Major facilitator Superfamily
JS278_01375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JS278_01377	COG0667	Aldo Keto reductase
JS278_01379	COG3201	nicotinamide mononucleotide transporter
JS278_01380	COG0140	phosphoribosyl-ATP diphosphatase activity
JS278_01381	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JS278_01388	COG0647	UMP catabolic process
JS278_01389	COG1268	BioY protein
JS278_01390	COG1122	ATPase activity
JS278_01393	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JS278_01394	COG0497	DNA recombination
JS278_01395	COG0504	CTP synthase activity
JS278_01402	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JS278_01406	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JS278_01407	COG0805	protein transport
JS278_01409	COG4581	dead DEAH box helicase
JS278_01410	COG0107	imidazoleglycerol-phosphate synthase activity
JS278_01411	COG0537	adenosine 5'-monophosphoramidase activity
JS278_01413	COG0440	acetolactate synthase activity
JS278_01414	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JS278_01418	COG0473	3-isopropylmalate dehydrogenase activity
JS278_01419	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JS278_01420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JS278_01422	COG0179	Fumarylacetoacetate (FAA) hydrolase
JS278_01426	COG1414	Transcriptional regulator
JS278_01427	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JS278_01428	COG0066	3-isopropylmalate dehydratase activity
JS278_01430	COG1181	Belongs to the D-alanine--D-alanine ligase family
JS278_01433	COG1674	ftsk spoiiie
JS278_01435	COG3152	Membrane
JS278_01437	COG0667	Aldo Keto reductase
JS278_01439	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JS278_01440	COG2884	Cell division ATP-binding protein ftsE
JS278_01441	COG2177	Part of the ABC transporter FtsEX involved in
JS278_01442	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JS278_01443	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JS278_01445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JS278_01446	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JS278_01447	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JS278_01448	COG0165	Argininosuccinate lyase
JS278_01451	COG1678	Uncharacterized ACR, COG1678
JS278_01452	COG0745	RESPONSE REGULATOR receiver
JS278_01453	COG5002	protein histidine kinase activity
JS278_01454	COG5401	PFAM Sporulation and spore germination
JS278_01456	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JS278_01458	COG0653	protein targeting
JS278_01462	COG0613	PHP domain protein
JS278_01464	COG0180	Tryptophanyl-tRNA synthetase
JS278_01469	COG1278	Cold shock
JS278_01470	COG0210	DNA helicase
JS278_01473	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JS278_01474	COG1074	ATP-dependent DNA helicase activity
JS278_01475	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JS278_01480	COG3480	Lon protease (S16) C-terminal proteolytic domain
JS278_01482	COG1615	UPF0182 protein
JS278_01488	COG0747	negative chemotaxis
JS278_01492	COG4172	Belongs to the ABC transporter superfamily
JS278_01493	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JS278_01494	COG0483	inositol monophosphate 1-phosphatase activity
JS278_01495	COG1162	GTPase activity
JS278_01496	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JS278_01498	COG1595	DNA-templated transcription, initiation
JS278_01504	COG0567	Dehydrogenase, E1 component
JS278_01504	COG0508	dehydrogenase complex catalyzes the overall conversion of
JS278_01506	COG1611	Belongs to the LOG family
JS278_01508	COG0019	diaminopimelate decarboxylase activity
JS278_01509	COG0460	homoserine dehydrogenase
JS278_01510	COG0083	homoserine kinase activity
JS278_01512	COG0254	rRNA binding
JS278_01513	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JS278_01514	COG2890	protein-(glutamine-N5) methyltransferase activity
JS278_01515	COG0009	L-threonylcarbamoyladenylate synthase
JS278_01516	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JS278_01518	COG2244	polysaccharide biosynthetic process
JS278_01530	COG0318	PFAM AMP-dependent synthetase and ligase
JS278_01532	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JS278_01533	COG0367	asparagine synthase
JS278_01535	COG1045	serine acetyltransferase
JS278_01538	COG0356	it plays a direct role in the translocation of protons across the membrane
JS278_01539	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JS278_01540	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JS278_01541	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JS278_01542	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JS278_01543	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JS278_01544	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JS278_01545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JS278_01549	COG0596	Alpha beta hydrolase
JS278_01556	COG0033	Phosphoglucomutase
JS278_01561	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JS278_01562	COG3281	Trehalose synthase
JS278_01563	COG0366	Alpha amylase catalytic
JS278_01567	COG1104	cysteine desulfurase activity
JS278_01568	COG0482	sulfurtransferase activity
JS278_01573	COG1129	ABC transporter
JS278_01573	COG0842	Transport permease protein
JS278_01574	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
JS278_01576	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JS278_01579	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JS278_01580	COG0154	amidase activity
JS278_01581	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JS278_01582	COG2233	PERMEase
JS278_01585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JS278_01586	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JS278_01589	COG0134	indole-3-glycerol-phosphate synthase activity
JS278_01590	COG0133	tryptophan synthase activity
JS278_01591	COG0159	tryptophan synthase activity
JS278_01592	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JS278_01593	COG0070	glutamate synthase
JS278_01593	COG0069	glutamate synthase activity
JS278_01593	COG0067	glutamate synthase
JS278_01599	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JS278_01600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JS278_01601	COG0131	Imidazoleglycerol-phosphate dehydratase
JS278_01602	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JS278_01603	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JS278_01604	COG0217	transcriptional regulatory protein
JS278_01605	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JS278_01606	COG0632	four-way junction helicase activity
JS278_01607	COG2255	four-way junction helicase activity
JS278_01609	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JS278_01610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JS278_01611	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JS278_01613	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JS278_01614	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JS278_01615	COG1196	nuclear chromosome segregation
JS278_01617	COG0124	histidyl-tRNA synthetase
JS278_01619	COG1309	transcriptional regulator
JS278_01621	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JS278_01622	COG2161	toxin-antitoxin pair type II binding
JS278_01630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JS278_01631	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JS278_01632	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JS278_01633	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JS278_01634	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JS278_01636	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JS278_01638	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JS278_01639	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JS278_01641	COG0194	GDP metabolic process
JS278_01642	COG1758	RNA polymerase activity
JS278_01644	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JS278_01645	COG1201	RNA secondary structure unwinding
JS278_01646	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JS278_01649	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JS278_01650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JS278_01652	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JS278_01654	COG0646	methionine synthase
JS278_01654	COG1410	methionine synthase
JS278_01657	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JS278_01658	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JS278_01660	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JS278_01661	COG1160	GTP binding
JS278_01663	COG1764	response to oxidative stress
JS278_01666	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JS278_01676	COG1484	DNA-dependent DNA replication
JS278_01686	COG2326	polyphosphate kinase activity
JS278_01688	COG1414	Transcriptional regulator
JS278_01690	COG1725	Transcriptional regulator
JS278_01692	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JS278_01697	COG3226	Transcriptional regulator
JS278_01700	COG0740	serine-type endopeptidase activity
JS278_01701	COG0740	serine-type endopeptidase activity
JS278_01702	COG3285	dna ligase
JS278_01702	COG1793	dna ligase
JS278_01705	COG3550	peptidyl-serine autophosphorylation
JS278_01710	COG2807	transmembrane transport
JS278_01713	COG0427	acetyl-CoA hydrolase
JS278_01715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JS278_01716	COG2813	Specifically methylates the guanine in position
JS278_01716	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JS278_01717	COG1522	sequence-specific DNA binding
JS278_01718	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JS278_01719	COG1216	Glycosyl transferase, family 2
JS278_01721	COG0584	glycerophosphoryl diester phosphodiesterase
JS278_01722	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JS278_01723	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JS278_01725	COG1966	Carbon starvation protein
JS278_01728	COG0531	amino acid
JS278_01732	COG0443	Heat shock 70 kDa protein
JS278_01734	COG1739	Uncharacterized protein family UPF0029
JS278_01736	COG1597	lipid kinase activity
JS278_01738	COG0009	L-threonylcarbamoyladenylate synthase
JS278_01740	COG0205	6-phosphofructokinase activity
JS278_01741	COG1295	ribonuclease BN
JS278_01745	COG1716	ATPase activity
JS278_01751	COG0438	transferase activity, transferring glycosyl groups
JS278_01752	COG1560	Kdo2-lipid A biosynthetic process
JS278_01755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JS278_01756	COG1064	alcohol dehydrogenase
JS278_01765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JS278_01766	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JS278_01767	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JS278_01768	COG0531	amino acid
JS278_01769	COG0569	domain protein
JS278_01773	COG0756	dUTP diphosphatase activity
JS278_01780	COG1297	OPT oligopeptide transporter protein
JS278_01782	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JS278_01786	COG0187	DNA topoisomerase II activity
JS278_01789	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JS278_01791	COG1643	Atp-dependent helicase
JS278_01796	COG0717	Belongs to the dCTP deaminase family
JS278_01797	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JS278_01798	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JS278_01801	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JS278_01802	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JS278_01803	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JS278_01805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JS278_01806	COG2017	converts alpha-aldose to the beta-anomer
JS278_01807	COG1418	mRNA catabolic process
JS278_01811	COG1349	DNA-binding transcription factor activity
JS278_01812	COG1396	sequence-specific DNA binding
JS278_01813	COG1546	Belongs to the CinA family
JS278_01813	COG1058	Belongs to the CinA family
JS278_01815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JS278_01817	COG4115	mRNA cleavage
JS278_01820	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JS278_01821	COG0284	orotidine-5'-phosphate decarboxylase activity
JS278_01822	COG0167	dihydroorotate dehydrogenase activity
JS278_01823	COG0543	2 iron, 2 sulfur cluster binding
JS278_01824	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JS278_01825	COG0505	Belongs to the CarA family
JS278_01827	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JS278_01830	COG0667	Aldo Keto reductase
JS278_01832	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JS278_01835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JS278_01837	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JS278_01838	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JS278_01839	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JS278_01841	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JS278_01842	COG2304	oxidoreductase activity
JS278_01843	COG2304	oxidoreductase activity
JS278_01845	COG0714	Associated with various cellular activities
JS278_01854	COG0477	Major facilitator Superfamily
JS278_01856	COG0515	serine threonine protein kinase
JS278_01857	COG0583	DNA-binding transcription factor activity
JS278_01859	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JS278_01861	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JS278_01865	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
JS278_01866	COG0488	(ABC) transporter
JS278_01871	COG0358	DNA primase activity
JS278_01872	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JS278_01878	COG1053	succinate dehydrogenase
JS278_01880	COG0076	glutamate decarboxylase activity
JS278_01883	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JS278_01885	COG0423	glycine-tRNA ligase activity
JS278_01888	COG1381	Involved in DNA repair and RecF pathway recombination
JS278_01889	COG1404	Belongs to the peptidase S8 family
JS278_01891	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JS278_01893	COG0765	amino acid transport
JS278_01894	COG0765	amino acid transport
JS278_01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JS278_01896	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JS278_01897	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JS278_01898	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JS278_01900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JS278_01912	COG4152	abc transporter atp-binding protein
JS278_01913	COG2197	response regulator
JS278_01914	COG4585	Histidine kinase
JS278_01915	COG0343	queuine tRNA-ribosyltransferase activity
JS278_01916	COG5006	permease, DMT superfamily
JS278_01920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS278_01920	COG2213	PTS system mannitol-specific
JS278_01921	COG0246	Mannitol dehydrogenase
JS278_01923	COG0484	heat shock protein binding
JS278_01924	COG1420	regulation of RNA biosynthetic process
JS278_01925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JS278_01926	COG0483	inositol monophosphate 1-phosphatase activity
JS278_01930	COG1175	transmembrane transport
JS278_01932	COG0477	Major facilitator Superfamily
JS278_01933	COG1309	transcriptional regulator
JS278_01934	COG1131	(ABC) transporter
JS278_01936	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JS278_01937	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JS278_01939	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JS278_01941	COG1169	isochorismate synthase
JS278_01942	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JS278_01943	COG4948	Mandelate Racemase Muconate Lactonizing
JS278_01948	COG0481	GTPase activity
JS278_01949	COG0268	Binds directly to 16S ribosomal RNA
JS278_01951	COG1061	Type III restriction enzyme res subunit
JS278_01952	COG2333	competence protein COMEC
JS278_01952	COG0658	competence protein
JS278_01954	COG0495	leucyl-tRNA aminoacylation
JS278_01958	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JS278_01969	COG0488	(ABC) transporter
JS278_01970	COG3226	Transcriptional regulator
JS278_01976	COG1131	(ABC) transporter
JS278_01978	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JS278_01983	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JS278_01990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JS278_01992	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JS278_01993	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JS278_01994	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JS278_01996	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JS278_01997	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JS278_01998	COG1530	ribonuclease E activity
JS278_02000	COG1472	Belongs to the glycosyl hydrolase 3 family
JS278_02002	COG0105	UTP biosynthetic process
JS278_02004	COG0285	dihydrofolate synthase activity
JS278_02006	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JS278_02007	COG0149	triose-phosphate isomerase activity
JS278_02008	COG0126	phosphoglycerate kinase activity
JS278_02009	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JS278_02010	COG1481	regulation of sporulation
JS278_02012	COG1660	Displays ATPase and GTPase activities
JS278_02013	COG0322	excinuclease ABC activity
JS278_02016	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JS278_02019	COG0556	nucleotide-excision repair
JS278_02020	COG0237	dephospho-CoA kinase activity
JS278_02021	COG0539	negative regulation of cytoplasmic translation
JS278_02026	COG2050	protein possibly involved in aromatic compounds catabolism
JS278_02029	COG0469	pyruvate kinase activity
JS278_02031	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JS278_02032	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JS278_02035	COG1799	cell septum assembly
JS278_02037	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JS278_02039	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JS278_02040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JS278_02041	COG0772	Belongs to the SEDS family
JS278_02042	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JS278_02043	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JS278_02044	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JS278_02046	COG0768	penicillin binding
JS278_02048	COG0275	rRNA processing
JS278_02049	COG2001	Belongs to the MraZ family
JS278_02050	COG0714	Associated with various cellular activities
JS278_02054	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JS278_02055	COG0509	glycine decarboxylation via glycine cleavage system
JS278_02056	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JS278_02056	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JS278_02058	COG3265	gluconokinase activity
JS278_02060	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JS278_02063	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JS278_02063	COG1116	anion transmembrane transporter activity
JS278_02068	COG0142	geranyltranstransferase activity
JS278_02069	COG0352	thiamine-phosphate diphosphorylase activity
JS278_02071	COG2815	serine threonine protein kinase
JS278_02071	COG0515	serine threonine protein kinase
JS278_02074	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JS278_02075	COG2197	response regulator
JS278_02079	COG1940	carbohydrate kinase activity
JS278_02080	COG0791	NLP P60 protein
JS278_02080	COG1388	LysM domain
JS278_02080	COG3103	Sh3 type 3 domain protein
JS278_02088	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JS278_02090	COG1845	cytochrome c oxidase, subunit III
JS278_02091	COG2010	Cytochrome c
JS278_02092	COG0723	plastoquinol--plastocyanin reductase activity
JS278_02093	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JS278_02097	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JS278_02098	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JS278_02106	COG0508	dehydrogenase complex catalyzes the overall conversion of
JS278_02107	COG0321	lipoyl(octanoyl) transferase activity
JS278_02108	COG3336	cytochrome c oxidase
JS278_02111	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JS278_02113	COG0488	(ABC) transporter
JS278_02115	COG0586	Pfam SNARE associated Golgi protein
JS278_02116	COG0438	transferase activity, transferring glycosyl groups
JS278_02119	COG0174	glutamine synthetase
JS278_02122	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JS278_02124	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JS278_02126	COG0174	glutamine synthetase
JS278_02134	COG2197	response regulator
JS278_02136	COG0598	Magnesium transport protein CorA
JS278_02140	COG0531	amino acid
JS278_02144	COG0006	proline dipeptidase activity
JS278_02151	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JS278_02152	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JS278_02155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JS278_02156	COG0297	glycogen (starch) synthase activity
JS278_02160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JS278_02161	COG2171	N-acyltransferase activity
JS278_02167	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JS278_02168	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JS278_02169	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JS278_02179	COG0647	UMP catabolic process
JS278_02181	COG0698	ribose 5-phosphate isomerase
JS278_02182	COG1349	DNA-binding transcription factor activity
JS278_02183	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JS278_02184	COG2376	Dihydroxyacetone kinase
JS278_02185	COG1063	alcohol dehydrogenase
JS278_02186	COG1012	belongs to the aldehyde dehydrogenase family
JS278_02190	COG1121	(ABC) transporter
JS278_02191	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JS278_02197	COG0765	amino acid transport
JS278_02201	COG2501	S4 domain
JS278_02207	COG0366	Alpha amylase catalytic
JS278_02208	COG0833	amino acid
JS278_02209	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JS278_02210	COG0667	Aldo Keto reductase
JS278_02211	COG2133	pyrroloquinoline quinone binding
JS278_02212	COG2716	regulation of RNA biosynthetic process
JS278_02219	COG0477	Major facilitator Superfamily
JS278_02220	COG0477	Major facilitator Superfamily
JS278_02221	COG0604	alcohol dehydrogenase
JS278_02221	COG3321	synthase
JS278_02222	COG1082	Xylose isomerase domain protein TIM barrel
JS278_02223	COG0673	inositol 2-dehydrogenase activity
JS278_02228	COG2169	Transcriptional regulator
JS278_02228	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JS278_02232	COG0406	alpha-ribazole phosphatase activity
JS278_02233	COG1132	(ABC) transporter
JS278_02236	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JS278_02258	COG2337	Toxic component of a toxin-antitoxin (TA) module
JS278_02259	COG0012	GTP binding
JS278_02262	COG1136	(ABC) transporter
JS278_02262	COG0577	efflux transmembrane transporter activity
JS278_02263	COG1362	aminopeptidase activity
JS278_02264	COG1322	Protein conserved in bacteria
JS278_02265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JS278_02266	COG1570	exodeoxyribonuclease VII activity
JS278_02267	COG1722	exodeoxyribonuclease VII activity
JS278_02269	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JS278_02271	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JS278_02272	COG1331	Highly conserved protein containing a thioredoxin domain
JS278_02276	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JS278_02279	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JS278_02280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JS278_02287	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JS278_02290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JS278_02291	COG0072	phenylalanine-tRNA ligase activity
JS278_02291	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JS278_02292	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JS278_02294	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JS278_02295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JS278_02296	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JS278_02297	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JS278_02305	COG0531	amino acid
JS278_02306	COG1834	amidinotransferase
JS278_02310	COG2837	iron assimilation
JS278_02312	COG2197	response regulator
JS278_02319	COG0148	phosphopyruvate hydratase activity
JS278_02324	COG1484	DNA-dependent DNA replication
JS278_02325	COG4584	PFAM Integrase catalytic
JS278_02326	COG0193	aminoacyl-tRNA hydrolase activity
JS278_02327	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JS278_02328	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JS278_02329	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JS278_02332	COG1846	Transcriptional regulator
JS278_02333	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JS278_02334	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JS278_02335	COG0084	hydrolase, TatD family'
JS278_02338	COG2233	PERMEase
JS278_02340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JS278_02341	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JS278_02348	COG2201	protein-glutamate methylesterase activity
JS278_02351	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JS278_02353	COG0693	protein deglycase activity
JS278_02355	COG0789	Transcriptional regulator
JS278_02361	COG1053	succinate dehydrogenase
JS278_02365	COG0673	inositol 2-dehydrogenase activity
JS278_02369	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JS278_02372	COG0436	Aminotransferase
JS278_02378	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JS278_02380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JS278_02383	COG1970	mechanosensitive ion channel activity
JS278_02387	COG0673	inositol 2-dehydrogenase activity
JS278_02388	COG2814	Major facilitator Superfamily
JS278_02389	COG0673	inositol 2-dehydrogenase activity
JS278_02390	COG1609	Transcriptional regulator
JS278_02391	COG2814	Major facilitator Superfamily
JS278_02394	COG3962	Belongs to the TPP enzyme family
JS278_02395	COG3718	enzyme involved in inositol metabolism
JS278_02397	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS278_02398	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JS278_02399	COG3118	belongs to the thioredoxin family
JS278_02401	COG1321	iron dependent repressor
JS278_02403	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JS278_02406	COG2252	PERMEase
JS278_02410	COG1278	Cold shock
JS278_02411	COG0363	glucosamine-6-phosphate deaminase activity
JS278_02422	COG0459	protein refolding
JS278_02424	COG1482	cell wall glycoprotein biosynthetic process
JS278_02425	COG1854	S-ribosylhomocysteine lyase activity
JS278_02429	COG4115	mRNA cleavage
JS278_02430	COG2161	toxin-antitoxin pair type II binding
JS278_02435	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
JS278_02436	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JS278_02438	COG1648	precorrin-2 dehydrogenase activity
JS278_02438	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JS278_02439	COG1797	cobyrinic acid a,c-diamide synthase activity
JS278_02440	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
JS278_02444	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
JS278_02445	COG0310	cobalt ion transport
JS278_02448	COG1648	precorrin-2 dehydrogenase activity
JS278_02448	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JS278_02450	COG2875	Belongs to the precorrin methyltransferase family
JS278_02452	COG1492	cobalamin metabolic process
JS278_02455	COG2197	response regulator
JS278_02456	COG4585	Histidine kinase
JS278_02457	COG1131	(ABC) transporter
JS278_02461	COG0406	alpha-ribazole phosphatase activity
JS278_02462	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JS278_02463	COG2197	response regulator
JS278_02464	COG4585	Histidine kinase
JS278_02466	COG1131	(ABC) transporter
JS278_02467	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JS278_02469	COG0156	8-amino-7-oxononanoate synthase activity
JS278_02470	COG1063	alcohol dehydrogenase
JS278_02471	COG0395	ABC-type sugar transport system, permease component
JS278_02472	COG1175	transmembrane transport
JS278_02474	COG1940	carbohydrate kinase activity
JS278_02475	COG1760	l-serine dehydratase
JS278_02479	COG3842	ATPase activity
JS278_02482	COG0626	cystathionine gamma-synthase activity
JS278_02485	COG0215	cysteine-tRNA ligase activity
JS278_02486	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JS278_02488	COG2814	Major facilitator Superfamily
JS278_02489	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JS278_02495	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JS278_02496	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JS278_02501	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JS278_02502	COG1063	alcohol dehydrogenase
JS278_02506	COG3732	PTS system glucitol sorbitol-specific
JS278_02509	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JS278_02512	COG1329	Transcriptional regulator
JS278_02515	COG5002	protein histidine kinase activity
JS278_02516	COG0704	Plays a role in the regulation of phosphate uptake
JS278_02517	COG0588	phosphoglycerate mutase activity
JS278_02518	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS278_02519	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JS278_02525	COG0191	fructose-bisphosphate aldolase activity
JS278_02528	COG0586	Pfam SNARE associated Golgi protein
JS278_02530	COG3291	Pkd domain containing protein
JS278_02532	COG0489	protein tyrosine kinase activity
JS278_02533	COG2244	polysaccharide biosynthetic process
JS278_02538	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JS278_02542	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JS278_02542	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JS278_02543	COG1704	LemA family
JS278_02547	COG0436	Aminotransferase
JS278_02550	COG4176	ABC-type proline glycine betaine transport system permease component
JS278_02551	COG0517	IMP dehydrogenase activity
JS278_02551	COG4175	Glycine betaine
JS278_02552	COG3012	SEC-C Motif Domain Protein
JS278_02557	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JS278_02559	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JS278_02565	COG1609	Transcriptional regulator
JS278_02566	COG2182	Extracellular solute-binding protein
JS278_02567	COG1175	transmembrane transport
JS278_02568	COG0395	ABC-type sugar transport system, permease component
JS278_02571	COG0702	epimerase
JS278_02572	COG1309	transcriptional regulator
JS278_02574	COG1511	domain protein
JS278_02577	COG1486	melibiose metabolic process
JS278_02579	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS278_02582	COG1175	transmembrane transport
JS278_02583	COG0395	ABC-type sugar transport system, permease component
JS278_02584	COG0542	response to heat
JS278_02586	COG3588	fructose-bisphosphate aldolase
JS278_02591	COG4585	Histidine kinase
JS278_02592	COG2197	response regulator
JS278_02597	COG1113	amino acid transport
JS278_02598	COG2985	domain, Protein
JS278_02598	COG0569	domain protein
JS278_02599	COG3527	Alpha-acetolactate decarboxylase
JS278_02600	COG1063	alcohol dehydrogenase
JS278_02601	COG0789	Transcriptional regulator
JS278_02602	COG0484	heat shock protein binding
JS278_02603	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JS278_02605	COG1125	glycine betaine transport
JS278_02605	COG0517	IMP dehydrogenase activity
JS278_02608	COG1764	response to oxidative stress
JS278_02610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JS278_02612	COG1733	regulation of RNA biosynthetic process
JS278_02613	COG0300	oxidoreductase activity
JS278_02616	COG0745	RESPONSE REGULATOR receiver
JS278_02617	COG2205	protein histidine kinase activity
JS278_02618	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JS278_02621	COG0574	Belongs to the PEP-utilizing enzyme family
JS278_02621	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JS278_02623	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JS278_02624	COG2813	Specifically methylates the guanine in position
JS278_02625	COG0560	Phosphoserine phosphatase
JS278_02625	COG3830	Belongs to the UPF0237 family
JS278_02630	COG1131	(ABC) transporter
JS278_02633	COG4608	Belongs to the ABC transporter superfamily
JS278_02634	COG0154	amidase activity
JS278_02637	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JS278_02638	COG1027	Aspartate ammonia-lyase
JS278_02639	COG1228	amidohydrolase
JS278_02647	COG0667	Aldo Keto reductase
JS278_02653	COG1940	carbohydrate kinase activity
JS278_02654	COG0018	arginyl-trna synthetase
JS278_02656	COG2814	Major facilitator Superfamily
JS278_02658	COG2113	Glycine betaine
JS278_02659	COG2949	membrane
JS278_02660	COG0166	Belongs to the GPI family
JS278_02662	COG4581	dead DEAH box helicase
JS278_02664	COG1881	PFAM PEBP family protein
JS278_02668	COG0667	Aldo Keto reductase
JS278_02670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JS278_02671	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JS278_02673	COG0148	phosphopyruvate hydratase activity
JS278_02677	COG2814	Major facilitator Superfamily
JS278_02678	COG0861	Integral membrane protein TerC family
JS278_02686	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JS278_02688	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
JS278_02689	COG0561	phosphatase activity
JS278_02690	COG0561	phosphatase activity
JS278_02696	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JS278_02697	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JS278_02704	COG3559	Exporter of polyketide antibiotics
JS278_02705	COG1131	(ABC) transporter
JS278_02707	COG1113	amino acid transport
JS278_02709	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JS278_02710	COG1695	Transcriptional regulator
JS278_02711	COG0477	Major facilitator Superfamily
JS278_02717	COG3311	Transcriptional regulator
JS278_02724	COG0438	transferase activity, transferring glycosyl groups
JS278_02727	COG0489	protein tyrosine kinase activity
JS278_02731	COG1316	TRANSCRIPTIONal
JS278_02735	COG0604	alcohol dehydrogenase
JS278_02737	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JS278_02738	COG1088	dTDP-glucose 4,6-dehydratase activity
JS278_02740	COG1716	ATPase activity
JS278_02741	COG1716	ATPase activity
JS278_02744	COG0768	penicillin binding
JS278_02745	COG0515	serine threonine protein kinase
JS278_02750	COG0393	Putative heavy-metal-binding
JS278_02752	COG1953	Uracil, thiamine, allantoin
JS278_02753	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JS278_02754	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JS278_02758	COG2186	Transcriptional regulator
JS278_02759	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JS278_02760	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JS278_02765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JS278_02769	COG1609	Transcriptional regulator
JS278_02770	COG1175	transmembrane transport
JS278_02771	COG0395	ABC-type sugar transport system, permease component
JS278_02772	COG1653	transport
JS278_02774	COG1454	alcohol dehydrogenase
JS278_02775	COG0477	Major facilitator Superfamily
JS278_02784	COG1271	oxidase subunit
JS278_02785	COG1294	oxidase, subunit
JS278_02786	COG4988	ABC transporter
JS278_02787	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JS278_02789	COG1556	Lactate utilization protein
JS278_02790	COG1139	Iron-sulfur cluster binding protein
JS278_02791	COG0247	lactate metabolic process
JS278_02792	COG1620	l-lactate permease
JS278_02793	COG2186	Transcriptional regulator
JS278_02795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JS278_02795	COG1013	pyruvate-flavodoxin oxidoreductase activity
JS278_02795	COG0674	pyruvate-flavodoxin oxidoreductase activity
JS278_02795	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JS278_02796	COG0167	dihydroorotate dehydrogenase activity
JS278_02798	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JS278_02801	COG1937	Protein conserved in bacteria
JS278_02802	COG0305	Participates in initiation and elongation during chromosome replication
JS278_02803	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JS278_02803	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JS278_02809	COG3118	belongs to the thioredoxin family
JS278_02811	COG0386	Belongs to the glutathione peroxidase family
JS278_02816	COG2094	Belongs to the DNA glycosylase MPG family
JS278_02818	COG1643	Atp-dependent helicase
JS278_02821	COG2897	thiosulfate sulfurtransferase activity
JS278_02829	COG0463	Glycosyl transferase, family 2
JS278_02834	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JS278_02835	COG1126	abc transporter atp-binding protein
JS278_02836	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JS278_02837	COG0765	amino acid transport
JS278_02838	COG0765	amino acid transport
JS278_02843	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JS278_02843	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS278_02843	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JS278_02850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JS278_02852	COG0438	transferase activity, transferring glycosyl groups
JS278_02853	COG0489	protein tyrosine kinase activity
JS278_02858	COG0438	transferase activity, transferring glycosyl groups
JS278_02859	COG0438	transferase activity, transferring glycosyl groups
JS278_02862	COG0463	Glycosyl transferase, family 2
JS278_02866	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JS278_02871	COG2801	Transposase and inactivated derivatives
JS278_02872	COG2963	transposase activity
JS278_02874	COG1309	transcriptional regulator
JS278_02876	COG2130	NADP-dependent
JS278_02878	COG2801	Transposase and inactivated derivatives
JS278_02884	COG1396	sequence-specific DNA binding
JS278_02886	COG3226	Transcriptional regulator
JS278_02888	COG2315	Protein conserved in bacteria
JS278_02889	COG1063	alcohol dehydrogenase
JS278_02898	COG2072	flavoprotein involved in K transport
JS278_02901	COG1247	-acetyltransferase
JS278_02903	COG1253	flavin adenine dinucleotide binding
JS278_02909	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JS278_02913	COG1063	alcohol dehydrogenase
JS278_02917	COG1119	ATPase activity
JS278_02920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JS278_02921	COG3069	C4-dicarboxylate transmembrane transporter activity
JS278_02924	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JS278_02928	COG1609	Transcriptional regulator
JS278_02929	COG0673	inositol 2-dehydrogenase activity
JS278_02930	COG2814	Major facilitator Superfamily
JS278_02931	COG1082	Xylose isomerase domain protein TIM barrel
JS278_02933	COG1609	Transcriptional regulator
JS278_02935	COG1172	Belongs to the binding-protein-dependent transport system permease family
JS278_02947	COG1175	transmembrane transport
JS278_02950	COG0457	Tetratricopeptide repeat
JS278_02951	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JS278_02953	COG5564	TIM-barrel signal transduction protein
JS278_02956	COG1482	cell wall glycoprotein biosynthetic process
JS278_02957	COG2814	Major facilitator Superfamily
JS278_02960	COG1070	Carbohydrate kinase
JS278_02965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JS278_02971	COG0464	growth
JS278_02973	COG1396	sequence-specific DNA binding
JS278_02974	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
JS278_02978	COG1201	RNA secondary structure unwinding
JS278_02980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JS278_02991	COG1609	Transcriptional regulator
JS278_02996	COG0584	glycerophosphoryl diester phosphodiesterase
JS278_02997	COG1609	Transcriptional regulator
JS278_02999	COG1285	pathogenesis
JS278_03000	COG0656	L-ascorbic acid biosynthetic process
JS278_03006	COG1609	Transcriptional regulator
JS278_03008	COG1129	ABC transporter
JS278_03009	COG1172	Belongs to the binding-protein-dependent transport system permease family
JS278_03010	COG1172	Belongs to the binding-protein-dependent transport system permease family
JS278_03013	COG2814	Major facilitator Superfamily
JS278_03015	COG0673	inositol 2-dehydrogenase activity
JS278_03016	COG1609	Transcriptional regulator
JS278_03017	COG3386	PFAM SMP-30 Gluconolaconase
JS278_03018	COG0352	thiamine-phosphate diphosphorylase activity
JS278_03019	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JS278_03019	COG0351	phosphomethylpyrimidine kinase
JS278_03019	COG0352	thiamine-phosphate diphosphorylase activity
JS278_03021	COG2364	Membrane
JS278_03023	COG0315	cyclic pyranopterin monophosphate synthase activity
JS278_03023	COG0521	Mo-molybdopterin cofactor biosynthetic process
JS278_03024	COG0315	cyclic pyranopterin monophosphate synthase activity
JS278_03027	COG0314	molybdopterin synthase activity
JS278_03033	COG1140	nitrate reductase beta subunit
JS278_03036	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JS278_03037	COG2124	cytochrome p450
JS278_03038	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JS278_03041	COG2337	Toxic component of a toxin-antitoxin (TA) module
JS278_03055	COG0435	Glutathione S-transferase
JS278_03057	COG0456	acetyltransferase
JS278_03061	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JS278_03063	COG2217	Heavy metal translocating P-type atpase
JS278_03070	COG0205	6-phosphofructokinase activity
JS278_03074	COG1136	(ABC) transporter
JS278_03083	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JS278_03084	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JS278_03084	COG1042	CoA-binding domain protein
JS278_03084	COG0045	succinate-CoA ligase (ADP-forming) activity
JS278_03085	COG1254	Belongs to the acylphosphatase family
JS278_03089	COG0281	malic enzyme
JS278_03090	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JS278_03091	COG0477	Major facilitator Superfamily
JS278_03094	COG2814	Major facilitator Superfamily
JS278_03096	COG2197	response regulator
JS278_03101	COG0564	pseudouridine synthase activity
JS278_03102	COG3118	belongs to the thioredoxin family
JS278_03105	COG4585	Histidine kinase
JS278_03113	COG2826	transposase and inactivated derivatives, IS30 family
JS278_03114	COG1082	Xylose isomerase domain protein TIM barrel
JS278_03115	COG0673	inositol 2-dehydrogenase activity
JS278_03116	COG1609	Transcriptional regulator
JS278_03120	COG0477	Major facilitator Superfamily
JS278_03122	COG2855	membrane
JS278_03124	COG0673	inositol 2-dehydrogenase activity
JS278_03126	COG0673	inositol 2-dehydrogenase activity
JS278_03127	COG2814	Major facilitator Superfamily
JS278_03128	COG2814	Major facilitator Superfamily
JS278_03129	COG1609	Transcriptional regulator
JS278_03130	COG2814	Major facilitator Superfamily
JS278_03133	COG1082	Xylose isomerase domain protein TIM barrel
JS278_03134	COG0673	inositol 2-dehydrogenase activity
JS278_03136	COG1012	belongs to the aldehyde dehydrogenase family
JS278_03137	COG2188	Transcriptional regulator
JS278_03139	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JS278_03140	COG1181	Belongs to the D-alanine--D-alanine ligase family
JS278_03143	COG1793	dna ligase
JS278_03143	COG3285	dna ligase
JS278_03145	COG1192	Involved in chromosome partitioning
JS278_03146	COG0357	Ribosomal RNA small subunit methyltransferase G
JS278_03147	COG2076	Multidrug Resistance protein
JS278_03149	COG0706	membrane insertase activity
JS278_03150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JS278_03151	COG0594	ribonuclease P activity