locus-tag	class	description
A5904_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
A5904_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
A5904_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
A5904_00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A5904_00030	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
A5904_00035	ENOG4107QMS	site-determining protein
A5904_00040	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
A5904_00045	ENOG4108Z4U	Ferredoxin
A5904_00050	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
A5904_00055	ENOG4108RPN	Protein smg homolog
A5904_00060	ENOG4105C79	DNA protecting protein DprA
A5904_00070	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
A5904_00075	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
A5904_00080	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
A5904_00085	ENOG4105ES5	Histidine kinase
A5904_00090	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
A5904_00095	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
A5904_00105	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
A5904_00110	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
A5904_00115	ENOG4107QJE	Chromosome Partitioning Protein
A5904_00120	ENOG4105FA0	parb-like partition protein
A5904_00130	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
A5904_00135	ENOG41082T0	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
A5904_00140	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
A5904_00145	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
A5904_00150	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
A5904_00155	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
A5904_00160	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
A5904_00165	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
A5904_00170	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
A5904_00175	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
A5904_00250	ENOG4105BZU	Histidine kinase
A5904_00265	ENOG4105C4R	Atp-dependent dna helicase
A5904_00275	ENOG4105E0F	Histidine kinase
A5904_00280	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
A5904_00295	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
A5904_00310	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
A5904_00320	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
A5904_00340	ENOG4105CV1	Transketolase (EC 2.2.1.1)
A5904_00345	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
A5904_00350	ENOG4105BZA	Phosphoglycerate kinase
A5904_00355	ENOG4105CA9	Pyruvate kinase
A5904_00360	ENOG4105D2N	Aldolase
A5904_00365	ENOG4105DJV	ribulose-phosphate 3-epimerase
A5904_00370	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
A5904_00375	ENOG4105CRQ	synthase (Component I)
A5904_00380	ENOG4105DDQ	anthranilate synthase
A5904_00385	ENOG4108I0Q	anthranilate phosphoribosyltransferase
A5904_00390	ENOG4105DK0	Indole-3-glycerol phosphate synthase
A5904_00405	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
A5904_00415	ENOG4105DHZ	alpha beta
A5904_00420	ENOG4105CJ1	ABC, transporter
A5904_00450	ENOG4105E7D	Protein of unknown function (DUF3375)
A5904_00475	ENOG4107MBT	Plasmid stabilisation system protein
A5904_00560	ENOG4105BZU	Histidine kinase
A5904_00565	ENOG4105K2Z	endo-1,4-d-glucanase (EC 3.2.1.4)
A5904_00615	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
A5904_00620	ENOG4108DMA	Nad-dependent epimerase dehydratase
A5904_00625	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
A5904_00630	ENOG4108TJN	glycosyl transferase group 1
A5904_00640	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
A5904_00660	ENOG4105MFV	ABC-2 type transporter
A5904_00685	ENOG4108MX3	Polysaccharide Biosynthesis Protein
A5904_00690	ENOG4105D3Q	Sugar transferase
A5904_00695	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
A5904_00700	ENOG4108UTZ	Dihydroxyacetone kinase
A5904_00705	ENOG4105CMT	Dihydroxyacetone kinase
A5904_00715	ENOG4105BZU	Histidine kinase
A5904_00725	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
A5904_00730	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
A5904_00740	ENOG4105CDU	Replicative dna helicase
A5904_00745	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
A5904_00755	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
A5904_00760	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
A5904_00765	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
A5904_00770	ENOG4105C0X	amino acid
A5904_00780	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
A5904_00795	ENOG4105C6T	cysteine synthase
A5904_00805	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
A5904_00820	ENOG4107U7B	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
A5904_00825	ENOG4105E0X	reductase
A5904_00830	ENOG4105BZU	Histidine kinase
A5904_00835	ENOG4107QYX	exodeoxyribonuclease v alpha
A5904_00840	ENOG4107QKA	exodeoxyribonuclease V beta
A5904_00845	ENOG4105DSY	exodeoxyribonuclease V, gamma
A5904_00855	ENOG4105E18	UPF0276 protein
A5904_00870	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
A5904_00880	ENOG4107WP9	Histidine kinase
A5904_00885	ENOG4105CD3	dihydroorotase
A5904_00890	ENOG4105CXT	aspartate transcarbamylase
A5904_00895	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
A5904_00900	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
A5904_00905	ENOG4108UJU	UPF0301 protein
A5904_00910	ENOG4105D7Z	glutathione synthase
A5904_00920	ENOG4105BZN	citrate synthase
A5904_00925	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
A5904_00975	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
A5904_00980	ENOG4105C08	Histidine kinase
A5904_00990	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
A5904_00995	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
A5904_01000	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
A5904_01010	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
A5904_01020	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
A5904_01045	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
A5904_01055	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
A5904_01060	ENOG4105NWN	ApaG protein
A5904_01065	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
A5904_01080	ENOG4105C5F	glutamine synthetase
A5904_01090	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
A5904_01095	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
A5904_01110	ENOG4105CHM	Aminotransferase
A5904_01115	ENOG4105D6E	homoserine dehydrogenase
A5904_01130	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
A5904_01140	ENOG4105CRK	lysyL-tRNA synthetase
A5904_01145	ENOG4105D60	lipoprotein releasing system transmembrane protein
A5904_01150	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
A5904_01160	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
A5904_01170	ENOG4109015	Biopolymer transport protein exbD tolR
A5904_01185	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
A5904_01190	ENOG4105W49	UPF0434 protein
A5904_01195	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
A5904_01225	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
A5904_01230	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
A5904_01235	ENOG4105SYT	Methylenetetrahydrofolate reductase
A5904_01255	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
A5904_01265	ENOG4105C54	Major Facilitator superfamily
A5904_01290	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
A5904_01295	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
A5904_01300	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
A5904_01305	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
A5904_01310	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
A5904_01315	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
A5904_01320	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
A5904_01325	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
A5904_01330	ENOG4105CIH	Imidazole acetol-phosphate transaminase
A5904_01335	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
A5904_01340	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
A5904_01345	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
A5904_01360	ENOG4105E3A	(ABC) transporter
A5904_01365	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
A5904_01375	ENOG4105EHM	Aminoglycoside phosphotransferase
A5904_01380	ENOG4108S0S	Nucleotidyl transferase
A5904_01395	ENOG4105C2X	Arabinose 5-phosphate isomerase
A5904_01400	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
A5904_01410	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
A5904_01415	ENOG4108IUZ	ABC transporter
A5904_01420	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
A5904_01425	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
A5904_01430	ENOG4105DM4	PTS System
A5904_01435	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
A5904_01440	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
A5904_01455	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
A5904_01465	ENOG4105CSM	endonuclease III
A5904_01475	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
A5904_01505	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
A5904_01510	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
A5904_01515	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
A5904_01525	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
A5904_01545	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
A5904_01550	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
A5904_01555	ENOG41080Z8	PHOSPHOCARRIER protein
A5904_01560	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
A5904_01570	ENOG4105CEN	a g-specific adenine glycosylase
A5904_01575	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
A5904_01605	ENOG4105C9Q	fumarate hydratase class II
A5904_01610	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
A5904_01620	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
A5904_01625	ENOG4107RAQ	aminopeptidase
A5904_01640	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
A5904_01645	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
A5904_01660	ENOG4105C8T	Leucyl-tRNA synthetase
A5904_01665	ENOG4105HBR	Rna-binding protein
A5904_01670	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
A5904_01690	ENOG4105F2I	Transposase
A5904_01705	ENOG4105ECI	YeeC-like protein
A5904_01770	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
A5904_01775	ENOG4108UJD	30S ribosomal protein S9
A5904_01780	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
A5904_01790	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
A5904_01810	ENOG4105C89	phosphohexose isomerase
A5904_01815	ENOG4105DZ1	carboxypeptidase
A5904_01820	ENOG4108JQC	penicillin-binding protein 1A
A5904_01845	ENOG4105DHQ	Histidine kinase
A5904_01850	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
A5904_01860	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
A5904_01870	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
A5904_01890	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
A5904_01895	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
A5904_01900	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
A5904_01905	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
A5904_01910	ENOG410890F	Dynamin family
A5904_01915	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
A5904_01925	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
A5904_01930	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
A5904_01935	ENOG4105CAK	Cell division ATP-binding protein ftsE
A5904_01940	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
A5904_01955	ENOG4105EGS	Mechanosensitive ion channel
A5904_01960	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
A5904_01965	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
A5904_01970	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
A5904_01980	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
A5904_01990	ENOG4105EMU	Dehydrogenase
A5904_02015	ENOG4105K2Z	endo-1,4-d-glucanase (EC 3.2.1.4)
A5904_02045	ENOG4107QZ7	Cellulose synthase catalytic subunit
A5904_02065	ENOG4105C1J	atp-dependent rna helicase
A5904_02070	ENOG4105VEQ	Cold shock protein
A5904_02090	ENOG4105F5W	AtP-binding protein
A5904_02140	ENOG4107QJZ	Glycosyl transferase, family 2
A5904_02145	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
A5904_02160	ENOG4105C25	Primosomal protein n'
A5904_02165	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
A5904_02175	ENOG4105PGM	cation diffusion facilitator family transporter
A5904_02180	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
A5904_02185	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
A5904_02195	ENOG4105C6W	4-alpha-glucanotransferase (EC 2.4.1.25)
A5904_02200	ENOG4105DKQ	ROK family
A5904_02215	ENOG4106BRA	Membrane
A5904_02225	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
A5904_02230	ENOG4105C9A	Phoh family
A5904_02235	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
A5904_02240	ENOG4108JU5	Magnesium and cobalt efflux protein
A5904_02245	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
A5904_02290	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
A5904_02295	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
A5904_02310	ENOG4105E18	UPF0276 protein
A5904_02330	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
A5904_02350	ENOG4107RDB	Major Facilitator
A5904_02360	ENOG4107TPS	domain protein
A5904_02375	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
A5904_02425	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
A5904_02440	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A5904_02445	ENOG4105K5M	30s ribosomal protein S16
A5904_02450	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
A5904_02455	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
A5904_02460	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
A5904_02475	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
A5904_02480	ENOG4105C0H	protease
A5904_02485	ENOG4107QR8	Thioredoxin
A5904_02500	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
A5904_02505	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
A5904_02510	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
A5904_02520	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
A5904_02525	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
A5904_02530	ENOG4107YIM	Involved in the transcription termination process (By similarity)
A5904_02545	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
A5904_02575	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
A5904_02585	ENOG4105PM1	preprotein translocase subunit SecE
A5904_02590	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
A5904_02595	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
A5904_02600	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
A5904_02605	ENOG4108VZM	50s ribosomal protein L10
A5904_02610	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
A5904_02615	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A5904_02620	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A5904_02625	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
A5904_02630	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
A5904_02635	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
A5904_02645	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
A5904_02650	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
A5904_02655	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
A5904_02660	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
A5904_02665	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
A5904_02670	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A5904_02675	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
A5904_02680	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
A5904_02685	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
A5904_02690	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
A5904_02700	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
A5904_02705	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
A5904_02710	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
A5904_02715	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A5904_02720	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
A5904_02725	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
A5904_02730	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
A5904_02735	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
A5904_02740	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
A5904_02745	ENOG41084RK	50S ribosomal protein L30
A5904_02750	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
A5904_02755	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
A5904_02760	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
A5904_02765	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
A5904_02770	ENOG41067V7	50S ribosomal protein L36
A5904_02775	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A5904_02780	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
A5904_02785	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
A5904_02790	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A5904_02795	ENOG4108ZT0	50S ribosomal protein l17
A5904_02800	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
A5904_02805	ENOG4108UUM	single-stranded DNA-binding protein
A5904_02820	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
A5904_02825	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
A5904_02830	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
A5904_02835	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
A5904_02845	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
A5904_02850	ENOG4105E66	phosphoriboisomerase A
A5904_02860	ENOG4105E2S	oxidase) subunit II
A5904_02865	ENOG4105BZ9	Cytochrome C oxidase, subunit I
A5904_02870	ENOG4107R3R	Cytochrome o ubiquinol oxidase subunit III
A5904_02885	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
A5904_02890	ENOG4107RDB	Major Facilitator
A5904_02895	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
A5904_02900	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
A5904_02905	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
A5904_02910	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
A5904_02930	ENOG4107QTZ	amino acid
A5904_02935	ENOG4105EAH	synthase
A5904_02945	ENOG4105CJN	penicillin-binding protein
A5904_02960	ENOG4105C5H	ABC transporter
A5904_02970	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
A5904_02990	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
A5904_02995	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
A5904_03015	ENOG4105M8F	Biopolymer transport protein exbD tolR
A5904_03045	ENOG4105CJN	penicillin-binding protein
A5904_03060	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
A5904_03065	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
A5904_03070	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
A5904_03075	ENOG4105C12	Phosphoribosylglycinamide synthetase
A5904_03080	ENOG4105DC1	bifunctional purine biosynthesis protein purh
A5904_03085	ENOG4108I6A	alcohol dehydrogenase
A5904_03090	ENOG4105C3G	gtp-binding protein
A5904_03095	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
A5904_03100	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
A5904_03105	ENOG4105CJN	penicillin-binding protein
A5904_03125	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
A5904_03130	ENOG4105D48	metallophosphoesterase
A5904_03140	ENOG4105WQI	isochorismatase
A5904_03145	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
A5904_03185	ENOG4108YV4	Universal stress protein
A5904_03190	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
A5904_03215	ENOG4105C4M	(Ubiquinol oxidase) subunit I
A5904_03225	ENOG4107QTZ	amino acid
A5904_03230	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
A5904_03235	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
A5904_03250	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
A5904_03265	ENOG410890F	Dynamin family
A5904_03285	ENOG41087PB	Frataxin-like domain
A5904_03290	ENOG4105C9U	ATP-dependent DNA helicase RecQ
A5904_03300	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
A5904_03310	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
A5904_03315	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
A5904_03320	ENOG4105CUX	Signal transduction histidine kinase
A5904_03325	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
A5904_03350	ENOG4105CAF	HipA N-terminal domain protein
A5904_03415	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
A5904_03445	ENOG4107WT5	transcriptional regulator (NifA
A5904_03510	ENOG4105CY0	Metallo-Beta-Lactamase
A5904_03515	ENOG41082GY	Binds directly to 16S ribosomal RNA (By similarity)
A5904_03520	ENOG4105C4R	Atp-dependent dna helicase
A5904_03530	ENOG4105DWY	Agmatine deiminase
A5904_03535	ENOG4105I08	Pseudouridine synthase
A5904_03545	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
A5904_03560	ENOG4105K63	Thioredoxin
A5904_03565	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
A5904_03570	ENOG4105VFB	Binds the 23S rRNA (By similarity)
A5904_03575	ENOG4105C6K	Malic enzyme
A5904_03580	ENOG4105C01	Dihydroxy-acid dehydratase
A5904_03590	ENOG4107QZM	n-acetylglutamate synthase
A5904_03600	ENOG4105K9H	YciI-like protein
A5904_03605	ENOG4107835	probably involved in intracellular septation (By similarity)
A5904_03615	ENOG4105ECY	inositol monophosphatase
A5904_03620	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
A5904_03630	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
A5904_03635	ENOG4105C3J	Cysteine desulfurase
A5904_03640	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
A5904_03645	ENOG4108Z4V	iron-sulfur cluster assembly
A5904_03650	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
A5904_03655	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
A5904_03660	ENOG4108ZIT	Ferredoxin, 2FE-2S
A5904_03665	ENOG4105WVQ	Fe-S assembly protein IscX
A5904_03670	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
A5904_03675	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
A5904_03680	ENOG4105BZU	Histidine kinase
A5904_03685	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
A5904_03695	ENOG4105C9X	ppx gppa phosphatase
A5904_03705	ENOG4105CE9	30S ribosomal protein S2
A5904_03710	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
A5904_03715	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
A5904_03720	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
A5904_03725	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
A5904_03730	ENOG4105KNE	Phosphatidate cytidylyltransferase
A5904_03735	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
A5904_03745	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A5904_03755	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A5904_03760	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
A5904_03765	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A5904_03780	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A5904_03785	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
A5904_03790	ENOG4105C0B	DNA polymerase III (alpha subunit)
A5904_03795	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
A5904_03800	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
A5904_03845	ENOG4105BZ1	(ABC) transporter
A5904_03865	ENOG4108RAC	Rubrerythrin
A5904_03880	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
A5904_03885	ENOG41080RH	Thioredoxin
A5904_03905	ENOG4105CJR	Integral membrane protein (MviN
A5904_03910	ENOG4105E4C	Lytic transglycosylase catalytic
A5904_03920	ENOG4105FAV	ABC, transporter
A5904_03930	ENOG4105FDK	ABC transporter
A5904_03935	ENOG4105EU0	Major facilitator Superfamily
A5904_03980	ENOG4108RGV	mercury transport protein MerC
A5904_04040	ENOG4105ERU	peptidase
A5904_04045	ENOG4105M00	molybdopterin converting factor, subunit 1
A5904_04050	ENOG4108ZAF	Molybdopterin
A5904_04055	ENOG4108VPT	UPF0234 protein
A5904_04065	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
A5904_04070	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
A5904_04075	ENOG4108EYQ	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A5904_04080	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A5904_04085	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
A5904_04100	ENOG4105BZ1	(ABC) transporter
A5904_04105	ENOG4108Z4U	Ferredoxin
A5904_04115	ENOG4105D3R	alkyl hydroperoxide reductase
A5904_04125	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
A5904_04140	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
A5904_04145	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
A5904_04170	ENOG4105KNY	Microcompartments protein
A5904_04175	ENOG4105KNY	Microcompartments protein
A5904_04180	ENOG4105KNY	Microcompartments protein
A5904_04255	ENOG4105C26	Dehydrogenase
A5904_04265	ENOG4105E0F	Histidine kinase
A5904_04270	ENOG41080HT	Transcriptional regulator, arsr family
A5904_04280	ENOG4108J5G	6-phosphogluconate dehydrogenase
A5904_04330	ENOG4105CSA	Coproporphyrinogen iii oxidase
A5904_04340	ENOG4105FE9	pseudouridine synthase
A5904_04345	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
A5904_04350	ENOG4105DZ1	carboxypeptidase
A5904_04375	ENOG4105EKE	dihydroorotase
A5904_04390	ENOG4108UXE	Protein tyrosine phosphatase
A5904_04425	ENOG4108594	Permease of the drug metabolite transporter
A5904_04430	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
A5904_04435	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
A5904_04475	ENOG4105DKD	Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity)
A5904_04525	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
A5904_04530	ENOG4105CSR	polyphosphate kinase 2
A5904_04535	ENOG4107QN2	dihydrolipoyl dehydrogenase
A5904_04545	ENOG4105CEV	competence damage-inducible protein
A5904_04550	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
A5904_04555	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
A5904_04570	ENOG4107S2Z	UPF0761 membrane protein
A5904_04580	ENOG41082GS	50S ribosomal protein L32
A5904_04585	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
A5904_04590	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
A5904_04595	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
A5904_04600	ENOG4105CHR	reductase
A5904_04605	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
A5904_04610	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
A5904_04620	ENOG4105HHA	aminodeoxychorismate lyase
A5904_04625	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
A5904_04630	ENOG4107QRG	dna polymerase iii
A5904_04800	ENOG4108TWJ	NADH dehydrogenase subunit 5
A5904_04805	ENOG4105EVH	UPF0753 protein
A5904_04820	ENOG4105C01	Dihydroxy-acid dehydratase
A5904_04825	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
A5904_04910	ENOG4108YXQ	IS66 Orf2 family protein
A5904_04955	ENOG4105F5W	AtP-binding protein
A5904_04970	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
A5904_05010	ENOG4105E18	UPF0276 protein
A5904_05030	ENOG4107QWP	ABC-2 type transporter
A5904_05035	ENOG4107QWP	ABC-2 type transporter
A5904_05040	ENOG4105CJ1	ABC, transporter
A5904_05050	ENOG4105DFG	type I secretion outer membrane protein
A5904_05060	ENOG4105W1Y	Transcriptional regulator
A5904_05095	ENOG4105C5I	Dehydrogenase
A5904_05100	ENOG4105EVH	UPF0753 protein
A5904_05105	ENOG4108TWJ	NADH dehydrogenase subunit 5
A5904_05115	ENOG4105BZU	Histidine kinase
A5904_05120	ENOG4108YYC	ycei family
A5904_05125	ENOG4105CS1	NAD(P)H quinone oxidoreductase
A5904_05130	ENOG4105KVH	Transcriptional regulator
A5904_05190	ENOG4107R3N	Filamentation induced by cAMP protein fic
A5904_05225	ENOG4107SVH	Potassium channel protein
A5904_05245	ENOG4105C7H	Helicase, RecD TraA family
A5904_05260	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
A5904_05265	ENOG4108MTB	glycosyl transferase family
A5904_05270	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
A5904_05275	ENOG4105KH3	nitrite reductase (NAD(P)h) small subunit
A5904_05280	ENOG4108IFG	nitrite reductase, (NAD(P)H)
A5904_05400	ENOG4105F5W	AtP-binding protein
A5904_05445	ENOG4105EXC	Acyl-transferase
A5904_05460	ENOG4105F5W	AtP-binding protein
A5904_05525	ENOG4108UUM	single-stranded DNA-binding protein
A5904_05615	ENOG4107SC1	transglycosylase
A5904_05635	ENOG4107QHF	type ii secretion system protein e
A5904_05710	ENOG4105PF0	Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin
A5904_05780	ENOG4105CVR	type I restriction-modification system
A5904_05850	ENOG4107QJE	Chromosome Partitioning Protein
A5904_05855	ENOG4105FA0	parb-like partition protein
A5904_05875	ENOG4105XB7	anti-repressor protein
A5904_05940	ENOG4105F5W	AtP-binding protein
A5904_06105	ENOG4105E4C	Lytic transglycosylase catalytic
A5904_06255	ENOG4108KU3	Integrase
A5904_06265	ENOG41090R7	Ferric uptake
A5904_06275	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
A5904_06285	ENOG4105CFU	surface antigen
A5904_06300	ENOG4107QMP	dna polymerase iii subunits gamma and tau
A5904_06305	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
A5904_06310	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
A5904_06320	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
A5904_06325	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
A5904_06330	ENOG4105CJW	magnesium transporter
A5904_06335	ENOG4105K8N	protein family UPF0079, ATPase
A5904_06345	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
A5904_06370	ENOG41082CH	UPF0145 protein
A5904_06390	ENOG4105C7B	Threonine dehydratase
A5904_06395	ENOG4105F4R	Transcriptional regulator mode
A5904_06400	ENOG4105DNZ	Alpha Beta Hydrolase
A5904_06410	ENOG4105DN3	alpha-2-macroglobulin domain protein
A5904_06415	ENOG4108JQB	penicillin-binding protein 1C
A5904_06420	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
A5904_06430	ENOG4105CPP	Dehydrogenase, E1 component
A5904_06435	ENOG4108JYK	Dehydrogenase
A5904_06445	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
A5904_06450	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
A5904_06465	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
A5904_06470	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
A5904_06485	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
A5904_06495	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
A5904_06505	ENOG4105K4H	Nlp p60 protein
A5904_06515	ENOG4105EUB	pirin domain protein
A5904_06525	ENOG4105CSR	polyphosphate kinase 2
A5904_06545	ENOG4105C54	Major Facilitator superfamily
A5904_06550	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
A5904_06560	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
A5904_06565	ENOG4105E02	MotA TolQ exbB proton channel
A5904_06570	ENOG4105M8F	Biopolymer transport protein exbD tolR
A5904_06595	ENOG4108IJ6	ABC transporter
A5904_06615	ENOG4105CW7	secretion protein, HlyD family
A5904_06625	ENOG4105E3B	Multicopper oxidase
A5904_06630	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
A5904_06635	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
A5904_06650	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
A5904_06655	ENOG4105CUT	histidyl-tRNA synthetase
A5904_06665	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
A5904_06670	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
A5904_06710	ENOG4105C8U	phosphate abc transporter
A5904_06720	ENOG4105DR4	Methyltransferase
A5904_06725	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
A5904_06735	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A5904_06740	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
A5904_06745	ENOG4105CQC	Prephenate dehydratase
A5904_06750	ENOG4105CIH	Imidazole acetol-phosphate transaminase
A5904_06755	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
A5904_06760	ENOG4105EVN	Prephenate dehydrogenase
A5904_06765	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
A5904_06770	ENOG4105CAT	Cytidine monophosphate kinase
A5904_06775	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
A5904_06780	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
A5904_06785	ENOG4105CFV	Tetratricopeptide repeat protein
A5904_06795	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
A5904_06800	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
A5904_06805	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
A5904_06810	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
A5904_06815	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
A5904_06820	ENOG4105K70	DNA-binding protein
A5904_06835	ENOG4105EIN	peptidylprolyl cis-trans isomerase
A5904_06865	ENOG4105BZU	Histidine kinase
A5904_06895	ENOG4105BZU	Histidine kinase
A5904_06910	ENOG4105X0D	Fimbrial protein
A5904_06940	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
A5904_06945	ENOG4108JQC	penicillin-binding protein 1A
A5904_06950	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
A5904_06955	ENOG4105C8N	cysteinyl-tRNA synthetase
A5904_06960	ENOG4107QQB	Ribonuclease E
A5904_06965	ENOG4105EI2	Pseudouridine synthase
A5904_06970	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
A5904_06975	ENOG4105E0C	molybdate abc transporter
A5904_06990	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
A5904_07005	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
A5904_07010	ENOG4105D07	Signal peptide peptidase, SppA
A5904_07015	ENOG4108FN7	Aldo keto reductase
A5904_07030	ENOG4105C8Q	Methyl-accepting chemotaxis
A5904_07035	ENOG4107R88	Chemotaxis protein (CheV)
A5904_07050	ENOG4105CBS	Chea signal transduction histidine kinase
A5904_07060	ENOG4108VYJ	response regulator receiver protein
A5904_07070	ENOG4106VK6	Flagellar motor protein
A5904_07080	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
A5904_07085	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
A5904_07100	ENOG4105CKS	Flagella basal body P-ring formation protein flgA
A5904_07105	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
A5904_07110	ENOG4108ZC9	flagellar basal-body rod protein flgc
A5904_07115	ENOG4105W00	Flagellar hook capping protein
A5904_07120	ENOG4105BZE	flagellar hook protein, FlgE
A5904_07125	ENOG4108KPB	Flagellar basal-body rod protein FlgF
A5904_07130	ENOG4105CGA	flagellar basal-body rod protein FlgG
A5904_07140	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
A5904_07145	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
A5904_07155	ENOG4105E1Q	flagellar hook-associated protein
A5904_07160	ENOG4105DTJ	flagellar hook-associated protein
A5904_07185	ENOG4105MQ3	flagellar protein FliS
A5904_07195	ENOG4108JUA	Transcriptional regulator
A5904_07200	ENOG4105BZU	Histidine kinase
A5904_07205	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
A5904_07210	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
A5904_07215	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
A5904_07220	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
A5904_07230	ENOG4108JIR	Flagellum-specific ATP synthase
A5904_07245	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
A5904_07250	ENOG4105DD5	Flagellar motor switch protein
A5904_07255	ENOG4105VTB	flagellar biosynthesis protein fliO
A5904_07260	ENOG4105CN7	Flagellar biosynthetic protein FliP
A5904_07265	ENOG4105VS8	Flagellar biosynthetic protein fliq
A5904_07270	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
A5904_07275	ENOG4105D00	flagellar biosynthetic protein flhB
A5904_07280	ENOG4105D7B	Flagellar biosynthesis protein flha
A5904_07285	ENOG4105FZW	flagellar biosynthesis regulator FlhF
A5904_07295	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
A5904_07300	ENOG4105E14	MotA TolQ exbB proton channel
A5904_07305	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
A5904_07310	ENOG4108MN8	Membrane
A5904_07330	ENOG4105CQB	FAD linked oxidase domain protein
A5904_07335	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
A5904_07340	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
A5904_07355	ENOG4105DJ0	Poly(A) Polymerase
A5904_07360	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
A5904_07365	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
A5904_07395	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
A5904_07400	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
A5904_07420	ENOG4105K78	MarR family Transcriptional regulator
A5904_07425	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
A5904_07435	ENOG4105CMQ	Chloride channel
A5904_07440	ENOG4105CMQ	Chloride channel
A5904_07445	ENOG4107RDB	Major Facilitator
A5904_07455	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
A5904_07480	ENOG4105DE4	1-phosphofructokinase
A5904_07485	ENOG4107QYA	phosphate
A5904_07520	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
A5904_07545	ENOG4105VUH	addiction module killer protein
A5904_07550	ENOG4105YES	addiction module antidote protein
A5904_07560	ENOG4105BZU	Histidine kinase
A5904_07565	ENOG4105BZU	Histidine kinase
A5904_07600	ENOG4105ER2	Ompa motb domain protein
A5904_07650	ENOG4105F5W	AtP-binding protein
A5904_07705	ENOG41079KZ	Major Facilitator Superfamily
A5904_07720	ENOG4105BZS	acriflavin resistance protein
A5904_07725	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
A5904_07745	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
A5904_07750	ENOG4105E0F	Histidine kinase
A5904_07790	ENOG4105F2I	Transposase
A5904_07815	ENOG4105C4M	(Ubiquinol oxidase) subunit I
A5904_07820	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
A5904_07830	ENOG4105DB1	molybdopterin oxidoreductase
A5904_07845	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
A5904_07850	ENOG4108KDI	dmso reductase anchor subunit
A5904_07880	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
A5904_07900	ENOG4108YXQ	IS66 Orf2 family protein
A5904_07965	ENOG4105E4C	Lytic transglycosylase catalytic
A5904_07990	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
A5904_08055	ENOG4108YXQ	IS66 Orf2 family protein
A5904_08065	ENOG4105C85	amino acid
A5904_08080	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
A5904_08085	ENOG4105BZS	acriflavin resistance protein
A5904_08110	ENOG4105EYM	Major Facilitator superfamily
A5904_08115	ENOG4105W2Z	cytochrome C, class I
A5904_08135	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
A5904_08150	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
A5904_08155	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
A5904_08160	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
A5904_08165	ENOG4108IAB	Phoh family
A5904_08170	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A5904_08185	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
A5904_08190	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A5904_08250	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A5904_08255	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A5904_08260	ENOG4105DUM	transcriptional regulator, lysR family
A5904_08270	ENOG4105CVK	Glutamate decarboxylase
A5904_08275	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
A5904_08280	ENOG4105DFU	Cell wall formation (By similarity)
A5904_08290	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
A5904_08315	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
A5904_08320	ENOG4105Y3E	Modulates RecA activity (By similarity)
A5904_08325	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
A5904_08330	ENOG4105CEV	competence damage-inducible protein
A5904_08335	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
A5904_08340	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
A5904_08355	ENOG4105PW4	Sugar fermentation stimulation protein homolog
A5904_08360	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
A5904_08370	ENOG41075W9	High frequency lysogenization protein HflD homolog
A5904_08380	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
A5904_08385	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
A5904_08395	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
A5904_08400	ENOG4107YRI	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
A5904_08405	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
A5904_08415	ENOG4105FE9	pseudouridine synthase
A5904_08420	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
A5904_08425	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
A5904_08430	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
A5904_08435	ENOG4105C31	Tryptophanyl-tRNA synthetase
A5904_08440	ENOG4108Z4T	Peptidase M50
A5904_08445	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
A5904_08450	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
A5904_08460	ENOG4105EGS	Mechanosensitive ion channel
A5904_08465	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
A5904_08490	ENOG4105BZU	Histidine kinase
A5904_08495	ENOG4105C0B	DNA polymerase III (alpha subunit)
A5904_08510	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
A5904_08520	ENOG4105EN6	Membrane
A5904_08525	ENOG4107QN2	dihydrolipoyl dehydrogenase
A5904_08530	ENOG4105W1Y	Transcriptional regulator
A5904_08535	ENOG4105Q84	sucrose synthase
A5904_08540	ENOG4105Q84	sucrose synthase
A5904_08545	ENOG4108KPW	sugar kinase
A5904_08555	ENOG4105E2Z	phosphate ABC transporter (Permease
A5904_08560	ENOG4105C8U	phosphate abc transporter
A5904_08565	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
A5904_08570	ENOG4105DTN	riboflavin biosynthesis protein ribF
A5904_08575	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
A5904_08580	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
A5904_08615	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
A5904_08620	ENOG4105K63	Thioredoxin
A5904_08625	ENOG4105VW4	glutaredoxin 3
A5904_08630	ENOG4105VFE	sira family
A5904_08640	ENOG4105BZS	acriflavin resistance protein
A5904_08655	ENOG41080HT	Transcriptional regulator, arsr family
A5904_08665	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
A5904_08680	ENOG4105CUZ	uba thif-type nad fad binding protein
A5904_08685	ENOG4105EYA	deoxyribonuclease
A5904_08690	ENOG4105D0A	hydroxylase
A5904_08695	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
A5904_08700	ENOG4105W0Z	cytoplasmic protein
A5904_08705	ENOG4105C0P	Mg chelatase subunit ChlI
A5904_08715	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
A5904_08720	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
A5904_08725	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
A5904_08730	ENOG4108ZP8	Acetolactate synthase small subunit
A5904_08735	ENOG4105C7K	acetolactate synthase
A5904_08740	ENOG4105C98	muts2 protein
A5904_08755	ENOG4108Z6B	deaminase
A5904_08780	ENOG4105E4G	Type IV pilus
A5904_08785	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
A5904_08790	ENOG4105D49	3-dehydroquinate synthase
A5904_08795	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
A5904_08800	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
A5904_08805	ENOG4105CBC	glutamate synthase
A5904_08810	ENOG4105BZ8	glutamate synthase
A5904_08815	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
A5904_08820	ENOG4108Z20	Acyl-transferase
A5904_08835	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
A5904_08840	ENOG4105EPW	hflc protein
A5904_08845	ENOG4107QJR	hflk protein
A5904_08850	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
A5904_08855	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
A5904_08860	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
A5904_08865	ENOG4108UHJ	MAF-like protein
A5904_08935	ENOG4108YXQ	IS66 Orf2 family protein
A5904_08970	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
A5904_08980	ENOG4108ZHR	arsR family transcriptional regulator
A5904_09070	ENOG4108R4U	Hnh endonuclease
A5904_09090	ENOG4105KAV	tspo and mbr like protein
A5904_09110	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
A5904_09120	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
A5904_09130	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
A5904_09135	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
A5904_09140	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
A5904_09145	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
A5904_09150	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
A5904_09340	ENOG4105C1J	atp-dependent rna helicase
A5904_09355	ENOG4108YZA	Nitrogen regulatory protein pii
A5904_09360	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
A5904_09370	ENOG4105BZU	Histidine kinase
A5904_09375	ENOG4108YZA	Nitrogen regulatory protein pii
A5904_09390	ENOG4105C5F	glutamine synthetase
A5904_09400	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
A5904_09405	ENOG4105CUX	Signal transduction histidine kinase
A5904_09475	ENOG4105VPX	protein, conserved in bacteria
A5904_09485	ENOG4108IJF	Heavy metal efflux pump, CzcA
A5904_09520	ENOG4105C59	p-type ATPase
A5904_09575	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
A5904_09590	ENOG4107TPS	domain protein
A5904_09600	ENOG4107RDB	Major Facilitator
A5904_09645	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
A5904_09650	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
A5904_09670	ENOG4105RQ5	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
A5904_09700	ENOG4108K3A	Glutathione S-transferase
A5904_09705	ENOG4108Z4U	Ferredoxin
A5904_09720	ENOG4105CRU	nitrate reductase, alpha subunit
A5904_09725	ENOG4108IUE	nitrate reductase beta subunit
A5904_09730	ENOG4105R3A	Nitrate reductase
A5904_09735	ENOG41076YT	nitrate reductase, gamma subunit
A5904_09745	ENOG4107QND	Nitrite extrusion protein
A5904_09750	ENOG4105K78	MarR family Transcriptional regulator
A5904_09760	ENOG4105CW7	secretion protein, HlyD family
A5904_09780	ENOG4105F5W	AtP-binding protein
A5904_09790	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
A5904_09845	ENOG4105F8V	Hydrolase, tatD family
A5904_09850	ENOG4105C2N	RNA methyltransferase TrmH family group 3
A5904_09860	ENOG4105IPI	Membrane
A5904_09865	ENOG4105DB7	PHP domain protein
A5904_09875	ENOG4105C02	permease
A5904_09880	ENOG4105C1Q	protoporphyrinogen oxidase
A5904_09890	ENOG4105CB5	ATP-dependent DNA helicase recG
A5904_09900	ENOG4105KME	endoribonuclease L-psp
A5904_09905	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
A5904_09910	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
A5904_09915	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
A5904_09920	ENOG4105DSJ	YicC domain protein
A5904_09925	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
A5904_09930	ENOG4105CM2	brancheD-chain amino acid aminotransferase
A5904_09940	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
A5904_09945	ENOG4105VF7	tolerance protein
A5904_09950	ENOG4105BZU	Histidine kinase
A5904_10005	ENOG4105WMR	Protein CrcB homolog
A5904_10015	ENOG4108KU3	Integrase
A5904_10115	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
A5904_10120	ENOG410624X	efflux transporter, rnd family, mfp subunit
A5904_10125	ENOG4105BZS	acriflavin resistance protein
A5904_10130	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
A5904_10145	ENOG4105I7R	Adenylate cyclase
A5904_10155	ENOG4105CD8	aminopeptidase N
A5904_10160	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
A5904_10165	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
A5904_10170	ENOG4105EAA	nucleoside
A5904_10175	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
A5904_10180	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
A5904_10185	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
A5904_10190	ENOG4105CTB	Polyprenyl synthetase
A5904_10200	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
A5904_10205	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
A5904_10210	ENOG4105VIE	preprotein translocase, subunit YajC
A5904_10215	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
A5904_10220	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
A5904_10225	ENOG4105C37	(CBS) domain
A5904_10235	ENOG4105C28	cystathionine
A5904_10240	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
A5904_10250	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
A5904_10255	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
A5904_10260	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
A5904_10265	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
A5904_10270	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
A5904_10275	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
A5904_10285	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
A5904_10290	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
A5904_10300	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
A5904_10305	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
A5904_10310	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
A5904_10315	ENOG4105N82	Endonuclease
A5904_10330	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
A5904_10355	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
A5904_10360	ENOG4105C4M	(Ubiquinol oxidase) subunit I
A5904_10375	ENOG4107QWP	ABC-2 type transporter
A5904_10380	ENOG4107QWP	ABC-2 type transporter
A5904_10385	ENOG4105CJ1	ABC, transporter
A5904_10405	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
A5904_10410	ENOG41081QV	Universal stress protein
A5904_10420	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
A5904_10425	ENOG4105C8V	SAICAR synthetase
A5904_10440	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
A5904_10450	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
A5904_10455	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
A5904_10465	ENOG4107RIQ	Sulfate adenylate transferase
A5904_10475	ENOG4105CRE	cytochrome C
A5904_10480	ENOG41088H4	Diheme cytochrome SoxA (Sulfur oxidation)
A5904_10490	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
A5904_10525	ENOG4105CCU	oxidase (Subunit III)
A5904_10530	ENOG4105BZ9	Cytochrome C oxidase, subunit I
A5904_10535	ENOG4105E2S	oxidase) subunit II
A5904_10540	ENOG4105F5W	AtP-binding protein
A5904_10550	ENOG4105F5W	AtP-binding protein
A5904_10565	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
A5904_10570	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
A5904_10575	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
A5904_10590	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
A5904_10610	ENOG410901P	UPF0249 protein
A5904_10615	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
A5904_10640	ENOG4105FE1	phytoene synthase
A5904_10645	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
A5904_10660	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
A5904_10680	ENOG4105D06	uba thif-type nad fad binding protein
A5904_10695	ENOG4105CY3	ABC transporter, permease
A5904_10700	ENOG4105DHJ	ABC, transporter
A5904_10705	ENOG4105DFG	type I secretion outer membrane protein
A5904_10750	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
A5904_10755	ENOG4105VTW	prevent-host-death family
A5904_10765	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
A5904_10770	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
A5904_10775	ENOG4105C98	muts2 protein
A5904_10780	ENOG4105KTH	gatB Yqey
A5904_10785	ENOG4105VCC	30S ribosomal protein S21
A5904_10790	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
A5904_10795	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
A5904_10800	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
A5904_10810	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
A5904_10815	ENOG4105M08	Membrane
A5904_10830	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
A5904_10845	ENOG4107QN2	dihydrolipoyl dehydrogenase
A5904_10860	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
A5904_10865	ENOG4105C4M	(Ubiquinol oxidase) subunit I
A5904_10870	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
A5904_10885	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
A5904_10905	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
A5904_10910	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
A5904_10915	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
A5904_10920	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
A5904_10925	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
A5904_10930	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
A5904_10935	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
A5904_10940	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
A5904_10945	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
A5904_10955	ENOG4105C3F	Signal peptidase i
A5904_10960	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
A5904_10965	ENOG4105C0H	protease
A5904_10975	ENOG4105EMN	RNA polymerase sigma factor
A5904_10980	ENOG4108IYU	L-aspartate oxidase
A5904_10985	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
A5904_10995	ENOG4108JJ8	(ABC) transporter
A5904_11000	ENOG4108JJ9	ABC, transporter
A5904_11015	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
A5904_11025	ENOG41072GX	Peptidase M22 Glycoprotease
A5904_11030	ENOG4105DVT	helicase
A5904_11040	ENOG4105CRE	cytochrome C
A5904_11045	ENOG4105K4H	Nlp p60 protein
A5904_11075	ENOG4105DQR	SNARE associated Golgi
A5904_11090	ENOG4105DUM	transcriptional regulator, lysR family
A5904_11110	ENOG4105FAE	von Willebrand factor, type A
A5904_11160	ENOG4105DF9	Lipoate-protein, ligase
A5904_11170	ENOG4105PHD	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
A5904_11180	ENOG4105RQ5	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
A5904_11185	ENOG41086B8	CoB-CoM heterodisulfide reductase
A5904_11200	ENOG4105EWK	phytoene
A5904_11215	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
A5904_11220	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
A5904_11225	ENOG41082J7	Rhodanese domain protein
A5904_11230	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
A5904_11235	ENOG4108KDI	dmso reductase anchor subunit
A5904_11240	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
A5904_11250	ENOG4105DB1	molybdopterin oxidoreductase
A5904_11260	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
A5904_11270	ENOG4105ES5	Histidine kinase
A5904_11280	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
A5904_11295	ENOG4105QN4	diheme cytochrome
A5904_11300	ENOG4105UUH	Domain of unknown function DUF302 
A5904_11305	ENOG4105CGH	5'-nucleotidase
A5904_11310	ENOG4105DFF	Rod shape-determining protein mreb
A5904_11315	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
A5904_11325	ENOG4105CJN	penicillin-binding protein
A5904_11330	ENOG4105CNI	cell division protein FtsW
A5904_11335	ENOG4105DZ1	carboxypeptidase
A5904_11345	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
A5904_11350	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
A5904_11395	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
A5904_11400	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
A5904_11405	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
A5904_11415	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
A5904_11440	ENOG4107QX9	Thiol disulfide interChange protein
A5904_11445	ENOG41090A4	Pterin carbinolamine dehydratase
A5904_11450	ENOG4105WPN	DNA integration recombination invertion protein
A5904_11460	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
A5904_11470	ENOG4105D3R	alkyl hydroperoxide reductase
A5904_11475	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
A5904_11510	ENOG4105F2I	Transposase
A5904_11515	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
A5904_11520	ENOG4105EU8	FAD linked oxidase domain protein
A5904_11525	ENOG4105CQB	FAD linked oxidase domain protein
A5904_11540	ENOG4108N16	Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region
A5904_11550	ENOG4105BZW	Glycerate kinase
A5904_11565	ENOG4108JUA	Transcriptional regulator
A5904_11595	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
A5904_11605	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
A5904_11610	ENOG41080FP	Hydrolase
A5904_11615	ENOG4107RAT	Ribulose bisphosphate carboxylase large chain, catalytic domain
A5904_11620	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
A5904_11625	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
A5904_11630	ENOG4105C34	Pseudouridine synthase
A5904_11635	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A5904_11640	ENOG4108YZA	Nitrogen regulatory protein pii
A5904_11650	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
A5904_11660	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
A5904_11665	ENOG4108HMX	isocitrate dehydrogenase (NADP)
A5904_11670	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
A5904_11680	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
A5904_11685	ENOG4105E9H	Lytic Murein transglycosylase
A5904_11690	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
A5904_11695	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
A5904_11705	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
A5904_11710	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
A5904_11715	ENOG4105CFH	Aspartokinase
A5904_11720	ENOG4105C8Y	Acetylornithine aminotransferase
A5904_11725	ENOG4105DBV	ornithine carbamoyltransferase
A5904_11730	ENOG4105CDH	Citrulline--aspartate ligase
A5904_11740	ENOG4108JDX	DNA polymerase iii, epsilon subunit
A5904_11745	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
A5904_11750	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
A5904_11755	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
A5904_11765	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
A5904_11770	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
A5904_11775	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
A5904_11780	ENOG41082KD	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
A5904_11785	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
A5904_11790	ENOG4105CHV	Transcription elongation factor NusA
A5904_11795	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
A5904_11880	ENOG4108TYN	CAAX amino terminal protease family protein
A5904_11890	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
A5904_11900	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
A5904_11905	ENOG4105D1H	recombination factor protein RarA
A5904_11915	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
A5904_11920	ENOG4105CNU	cell division protein FtsK
A5904_11925	ENOG4105C3M	thioredoxin reductase
A5904_11930	ENOG4105C98	muts2 protein
A5904_11940	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
A5904_11945	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
A5904_11950	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
A5904_11955	ENOG4108JA2	transcriptioN-repair coupling factor
A5904_11960	ENOG4105EAC	phosphoserine phosphatase
A5904_11965	ENOG4105EHV	domain protein
A5904_11970	ENOG4105DC8	reductase
A5904_11975	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
A5904_11980	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
A5904_12000	ENOG41085FU	Diacylglycerol kinase
A5904_12005	ENOG4105W5Q	DNA repair protein (RadC
A5904_12010	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
A5904_12015	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
A5904_12025	ENOG4105DHP	deoxycytidine triphosphate deaminase
A5904_12040	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
A5904_12045	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
A5904_12050	ENOG4105CFG	Acts as a chaperone (By similarity)
A5904_12055	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A5904_12060	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
A5904_12065	ENOG4105W0E	50S ribosomal protein L33
A5904_12070	ENOG4105KDC	50s ribosomal protein l28
A5904_12075	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
A5904_12140	ENOG4105EWK	phytoene
A5904_12160	ENOG4105EMU	Dehydrogenase
A5904_12170	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
A5904_12175	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
A5904_12180	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
A5904_12185	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
A5904_12195	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
A5904_12200	ENOG4105CP7	Triose-phosphate isomerase
A5904_12215	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A5904_12220	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A5904_12225	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A5904_12230	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A5904_12245	ENOG4108IEH	NADH dehydrogenase subunit g
A5904_12250	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
A5904_12255	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A5904_12260	ENOG4105DF2	NADH dehydrogenase subunit j
A5904_12265	ENOG41080FQ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A5904_12275	ENOG4105C8S	subunit m
A5904_12280	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A5904_12295	ENOG4105C22	threonyL-tRNA synthetase
A5904_12300	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
A5904_12305	ENOG41082NX	50s ribosomal protein l35
A5904_12310	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
A5904_12315	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
A5904_12320	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
A5904_12325	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
A5904_12330	ENOG4105WJX	transcriptional regulator MERR family
A5904_12375	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A5904_12380	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A5904_12385	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A5904_12390	ENOG4105GKE	subunit e
A5904_12400	ENOG4107R0R	NADH dehydrogenase subunit g
A5904_12405	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
A5904_12410	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A5904_12420	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A5904_12425	ENOG4105D65	subunit l
A5904_12430	ENOG4105C8S	subunit m
A5904_12435	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A5904_12450	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
A5904_12470	ENOG41090R7	Ferric uptake
A5904_12475	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
A5904_12485	ENOG4105DZQ	phospholipase D Transphosphatidylase
A5904_12505	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
A5904_12515	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
A5904_12525	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
A5904_12530	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
A5904_12535	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
A5904_12540	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
A5904_12565	ENOG4105CZX	twitching motility protein
A5904_12570	ENOG4105CZX	twitching motility protein
A5904_12575	ENOG4105DFA	alanine racemase domain protein
A5904_12580	ENOG4105II7	pyrroline-5-carboxylate reductase
A5904_12585	ENOG4108VIA	integral membrane protein
A5904_12590	ENOG4105VZ9	UPF0235 protein
A5904_12595	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
A5904_12605	ENOG4105CW7	secretion protein, HlyD family
A5904_12615	ENOG4105CAS	nag kinase
A5904_12640	ENOG4108EX3	reductase
A5904_12645	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
A5904_12650	ENOG4105C4B	ABC transporter, permease
A5904_12655	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
A5904_12660	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
A5904_12665	ENOG4105D0M	Protease HtpX homolog
A5904_12670	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
A5904_12675	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
A5904_12680	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
A5904_12685	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
A5904_12690	ENOG4105MJ2	Competence protein
A5904_12695	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
A5904_12700	ENOG41079KZ	Major Facilitator Superfamily
A5904_12710	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
A5904_12715	ENOG4105C87	Aminotransferase class I and II
A5904_12720	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
A5904_12730	ENOG4105D16	lipopolysaccharide heptosyltransferase i
A5904_12755	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
A5904_12765	ENOG4105CKK	Glycosyl transferase, family 2
A5904_12770	ENOG4105M6F	mutator MutT protein
A5904_12775	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
A5904_12780	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
A5904_12790	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A5904_12795	ENOG4107MKT	Stringent starvation protein a
A5904_12815	ENOG4108V6E	Cell division protein mraZ
A5904_12820	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
A5904_12830	ENOG4105CJN	penicillin-binding protein
A5904_12835	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
A5904_12840	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
A5904_12845	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
A5904_12850	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
A5904_12855	ENOG4105CNI	cell division protein FtsW
A5904_12860	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
A5904_12865	ENOG4105DFU	Cell wall formation (By similarity)
A5904_12870	ENOG4105D4A	Cell wall formation (By similarity)
A5904_12875	ENOG4105CPF	Cell wall formation (By similarity)
A5904_12880	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
A5904_12885	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
A5904_12890	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
A5904_12900	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
A5904_12910	ENOG4105CN1	protease
A5904_12915	ENOG4107S0N	DJ-1 family
A5904_12920	ENOG4107TF3	peptidylprolyl cis-trans isomerase
A5904_12925	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
A5904_12930	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
A5904_12935	ENOG4105DWV	Homoserine O-trans-acetylase
A5904_12940	ENOG4105DWV	Homoserine O-trans-acetylase
A5904_12945	ENOG4107MKT	Stringent starvation protein a
A5904_12955	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
A5904_12985	ENOG4105CJN	penicillin-binding protein
A5904_12990	ENOG4105K6T	rare lipoprotein A
A5904_13000	ENOG4107SVH	Potassium channel protein
A5904_13005	ENOG4105CJN	penicillin-binding protein
A5904_13010	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A5904_13015	ENOG4105C0H	protease
A5904_13020	ENOG4105DZ1	carboxypeptidase
A5904_13025	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
A5904_13045	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
A5904_13050	ENOG4105K46	50S ribosomal protein l27
A5904_13055	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A5904_13060	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
A5904_13070	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
A5904_13075	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
A5904_13080	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
A5904_13085	ENOG4105CH7	arginosuccinase
A5904_13100	ENOG4105CUV	Homoserine Kinase
A5904_13115	ENOG4105C2M	dna polymerase I
A5904_13120	ENOG4107SVH	Potassium channel protein
A5904_13125	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
A5904_13130	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
A5904_13135	ENOG4105CRE	cytochrome C
A5904_13145	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
A5904_13150	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
A5904_13155	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
A5904_13160	ENOG4105CMG	Carbohydrate kinase
A5904_13165	ENOG4105C54	Major Facilitator superfamily
A5904_13175	ENOG4105C5H	ABC transporter
A5904_13255	ENOG4105NVB	glycoside hydrolase, family 19
A5904_13275	ENOG4105NVB	glycoside hydrolase, family 19
A5904_13365	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
A5904_13375	ENOG41082RQ	UPF0102 protein
A5904_13380	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
A5904_13385	ENOG4105CQB	FAD linked oxidase domain protein
A5904_13395	ENOG4105XA0	heptosyltransferase ii
A5904_13410	ENOG4105DZ2	Transcriptional regulator
A5904_13415	ENOG4105D4P	Coproporphyrinogen iii oxidase
A5904_13435	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
A5904_13450	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
A5904_13460	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
A5904_13465	ENOG4105ED9	Protein of unknown function (DUF455)
A5904_13525	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
A5904_13555	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
A5904_13565	ENOG4105C9M	aspartyl-trna synthetase
A5904_13570	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
A5904_13575	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
A5904_13585	ENOG4105CDY	transcriptional regulatory protein
A5904_13590	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
A5904_13595	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
A5904_13600	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
A5904_13605	ENOG4107YD3	Thioesterase
A5904_13610	ENOG4105E02	MotA TolQ exbB proton channel
A5904_13615	ENOG4105M8F	Biopolymer transport protein exbD tolR
A5904_13625	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
A5904_13630	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
A5904_13635	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
A5904_13645	ENOG4105KCK	Peptidoglycan-associated lipoprotein
A5904_13650	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
A5904_13660	ENOG4105D52	delta-aminolevulinic acid dehydratase
A5904_13675	ENOG4105C54	Major Facilitator superfamily
A5904_13680	ENOG4108UT2	hemolysin iii
A5904_13705	ENOG4105C03	ribonuclease
A5904_13710	ENOG4108Z03	MAF-like protein
A5904_13725	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
A5904_13735	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
A5904_13750	ENOG4105D1S	lipid A biosynthesis
A5904_13755	ENOG4105MYT	Heat shock protein
A5904_13760	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
A5904_13765	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
A5904_13770	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
A5904_13775	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
A5904_13780	ENOG4105VG0	50S ribosomal protein l34
A5904_13785	ENOG4105DHJ	ABC, transporter
A5904_13790	ENOG4105CY3	ABC transporter, permease
A5904_13795	ENOG4107PE3	Mammalian cell entry related domain protein
A5904_13810	ENOG4105DA5	(ABC) transporter
A5904_13815	ENOG41082I2	s4 domain protein
A5904_13820	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
A5904_13830	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
A5904_13845	ENOG4105C75	arginyL-tRNA synthetase
A5904_13850	ENOG4105EGS	Mechanosensitive ion channel
A5904_13855	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
A5904_13860	ENOG4107NQ8	LysR family Transcriptional regulator
A5904_13865	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
A5904_13870	ENOG4105CGK	Exodeoxyribonuclease III
A5904_13880	ENOG4105D6S	protein involved in catabolism of external DNA
A5904_13885	ENOG4108U78	Glutathione S-transferase
A5904_13890	ENOG4105CGK	Exodeoxyribonuclease III
A5904_13895	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
A5904_13900	ENOG4108YZY	peptidylprolyl cis-trans isomerase
A5904_13905	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
A5904_13910	ENOG4105E2X	shikimate dehydrogenase
A5904_13915	ENOG4107QHF	type ii secretion system protein e
A5904_13920	ENOG4107TUY	Histidine kinase
A5904_13925	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
A5904_13935	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
A5904_13940	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
A5904_13945	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A5904_13960	ENOG4105E4C	Lytic transglycosylase catalytic
A5904_13965	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
A5904_13975	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
A5904_13980	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
A5904_13985	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
A5904_13990	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
A5904_14010	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
A5904_14015	ENOG4107ZUX	Histidine triad (HIT) protein
A5904_14020	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
A5904_14025	ENOG4107S5G	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
A5904_14030	ENOG4105DWF	phosphomethylpyrimidine kinase
A5904_14040	ENOG4105DTD	Dehydrogenase
A5904_14055	ENOG4105M8F	Biopolymer transport protein exbD tolR
A5904_14075	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
A5904_14245	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
A5904_14250	ENOG4105DUM	transcriptional regulator, lysR family
A5904_14275	ENOG4105KT5	UmuD protein
A5904_14290	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
A5904_14315	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
A5904_14325	ENOG4108CFY	Plasmid stabilisation system protein
A5904_14385	ENOG4105C4R	Atp-dependent dna helicase
A5904_14400	ENOG4105CB5	ATP-dependent DNA helicase recG
A5904_14450	ENOG4105F5W	AtP-binding protein
A5904_14470	ENOG4105F2I	Transposase
A5904_14495	ENOG4105FTC	Lytic transglycosylase catalytic
A5904_14500	ENOG4108VPC	n-acetylmuramoyl-l-alanine amidase
A5904_14545	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
A5904_14560	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
A5904_14600	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A5904_14610	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A5904_14620	ENOG4108UUM	single-stranded DNA-binding protein
A5904_14690	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
A5904_14725	ENOG4105M8F	Biopolymer transport protein exbD tolR
A5904_14745	ENOG4105F5W	AtP-binding protein
A5904_14760	ENOG4108I5C	dEAD DEAH box helicase
A5904_14765	ENOG4105C0D	helicase
A5904_14880	ENOG4105EKQ	RNA-directed DNA polymerase
A5904_14930	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
A5904_14935	ENOG4107QZ7	Cellulose synthase catalytic subunit
A5904_15050	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
A5904_15105	ENOG4107QJE	Chromosome Partitioning Protein
A5904_15110	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
A5904_15120	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
A5904_15410	ENOG4105FDP	GntR family transcriptional regulator
A5904_15415	ENOG4108C33	Resolvase
A5904_15440	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
A5904_15525	ENOG4105C4M	(Ubiquinol oxidase) subunit I
A5904_15600	ENOG4105F5W	AtP-binding protein
A5904_15625	ENOG4105F2I	Transposase
A5904_15660	ENOG4108YXQ	IS66 Orf2 family protein
A5904_15695	ENOG4108YXQ	IS66 Orf2 family protein
A5904_15770	ENOG4108YXQ	IS66 Orf2 family protein
A5904_15905	ENOG4105F2I	Transposase
A5904_15935	ENOG4108YXQ	IS66 Orf2 family protein
A5904_15975	ENOG4105F2I	Transposase
A5904_15990	ENOG4105F2I	Transposase
A5904_16000	ENOG4107QZ7	Cellulose synthase catalytic subunit
A5904_16005	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
A5904_16115	ENOG4108YXQ	IS66 Orf2 family protein
A5904_16220	ENOG4108YXQ	IS66 Orf2 family protein