locus-tag	class	description
Atc_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Atc_0002	COG0592	DNA-directed DNA polymerase activity
Atc_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Atc_0004	COG0187	DNA topoisomerase II activity
Atc_0005	COG0543	2 iron, 2 sulfur cluster binding
Atc_0005	COG0493	'glutamate synthase
Atc_0006	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Atc_0008	COG0850	regulation of cytokinetic process
Atc_0009	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Atc_0010	COG1754	DNA topoisomerase type I activity
Atc_0010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Atc_0011	COG2922	Belongs to the Smg family
Atc_0012	COG0758	DNA mediated transformation
Atc_0013	COG0242	peptide deformylase activity
Atc_0015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Atc_0016	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Atc_0016	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Atc_0017	COG5000	phosphorelay sensor kinase activity
Atc_0018	COG2204	response regulator
Atc_0019	COG0521	Mo-molybdopterin cofactor biosynthetic process
Atc_0022	COG0445	tRNA wobble uridine modification
Atc_0023	COG0357	Ribosomal RNA small subunit methyltransferase G
Atc_0024	COG1192	Involved in chromosome partitioning
Atc_0025	COG1475	DNA binding
Atc_0027	COG0356	it plays a direct role in the translocation of protons across the membrane
Atc_0029	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Atc_0030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Atc_0031	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Atc_0032	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Atc_0035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Atc_0038	COG1484	DNA-dependent DNA replication
Atc_0039	COG4584	PFAM Integrase catalytic
Atc_0053	COG0745	RESPONSE REGULATOR receiver
Atc_0053	COG3706	GGDEF domain
Atc_0056	COG0210	DNA helicase
Atc_0059	COG0745	RESPONSE REGULATOR receiver
Atc_0062	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Atc_0065	COG1970	mechanosensitive ion channel activity
Atc_0066	COG1322	Protein conserved in bacteria
Atc_0067	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Atc_0069	COG0483	inositol monophosphate 1-phosphatase activity
Atc_0070	COG1494	fructose-1,6-bisphosphatase
Atc_0071	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Atc_0072	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Atc_0073	COG0126	phosphoglycerate kinase activity
Atc_0074	COG0469	pyruvate kinase activity
Atc_0077	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Atc_0078	COG0546	phosphoglycolate phosphatase activity
Atc_0080	COG0512	Glutamine amidotransferase of anthranilate synthase
Atc_0081	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Atc_0082	COG0134	indole-3-glycerol-phosphate synthase activity
Atc_0085	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Atc_0087	COG2945	thiolester hydrolase activity
Atc_0088	COG1131	(ABC) transporter
Atc_0093	COG4942	peptidase
Atc_0098	COG3668	Plasmid stabilization system
Atc_0099	COG1475	DNA binding
Atc_0100	COG1192	Involved in chromosome partitioning
Atc_0107	COG3039	Transposase
Atc_0116	COG0741	lytic transglycosylase activity
Atc_0126	COG0463	Glycosyl transferase, family 2
Atc_0131	COG3039	Transposase
Atc_0133	COG3547	Transposase (IS116 IS110 IS902 family)
Atc_0137	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Atc_0139	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Atc_0142	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Atc_0146	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Atc_0147	COG3039	Transposase
Atc_0148	COG0745	RESPONSE REGULATOR receiver
Atc_0149	COG1937	Protein conserved in bacteria
Atc_0152	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Atc_0162	COG3701	Conjugal transfer protein
Atc_0168	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Atc_0175	COG3039	Transposase
Atc_0177	COG3039	Transposase
Atc_0180	COG0629	single-stranded DNA binding
Atc_0184	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Atc_0185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Atc_0189	COG0109	protoheme IX farnesyltransferase activity
Atc_0193	COG0745	RESPONSE REGULATOR receiver
Atc_0195	COG2198	Histidine kinase
Atc_0195	COG0643	Histidine kinase
Atc_0198	COG0840	transmembrane signaling receptor activity
Atc_0199	COG0835	chemotaxis
Atc_0199	COG0784	Response regulator, receiver
Atc_0201	COG2200	EAL domain
Atc_0204	COG1484	DNA-dependent DNA replication
Atc_0209	COG0438	transferase activity, transferring glycosyl groups
Atc_0215	COG3436	PFAM IS66 Orf2 family protein
Atc_0216	COG2433	Pfam Transposase IS66
Atc_0222	COG1215	transferase activity, transferring glycosyl groups
Atc_0227	COG1461	Dihydroxyacetone kinase
Atc_0229	COG2376	Dihydroxyacetone kinase
Atc_0235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Atc_0237	COG0305	Participates in initiation and elongation during chromosome replication
Atc_0238	COG0359	binds to the 23S rRNA
Atc_0240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Atc_0241	COG0360	Binds together with S18 to 16S ribosomal RNA
Atc_0242	COG1472	Belongs to the glycosyl hydrolase 3 family
Atc_0243	COG0531	amino acid
Atc_0245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Atc_0250	COG0363	glucosamine-6-phosphate deaminase activity
Atc_0252	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Atc_0253	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Atc_0255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Atc_0256	COG1074	ATP-dependent DNA helicase activity
Atc_0257	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Atc_0259	COG3220	belongs to the UPF0276 family
Atc_0262	COG2204	response regulator
Atc_0264	COG2205	protein histidine kinase activity
Atc_0265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Atc_0266	COG0540	Belongs to the ATCase OTCase family
Atc_0267	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Atc_0269	COG1678	Uncharacterized ACR, COG1678
Atc_0270	COG0189	ligase activity
Atc_0273	COG0316	Belongs to the HesB IscA family
Atc_0277	COG3431	PFAM Phosphate-starvation-inducible E
Atc_0279	COG0022	dehydrogenase e1 component
Atc_0279	COG0508	dehydrogenase complex catalyzes the overall conversion of
Atc_0280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Atc_0282	COG0471	metal ion transport
Atc_0282	COG3273	potassium ion transport
Atc_0283	COG0745	RESPONSE REGULATOR receiver
Atc_0284	COG2205	protein histidine kinase activity
Atc_0285	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Atc_0286	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Atc_0287	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Atc_0289	COG0415	Belongs to the DNA photolyase family
Atc_0291	COG2814	Major facilitator Superfamily
Atc_0296	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Atc_0298	COG2226	methyltransferase
Atc_0299	COG2967	ApaG domain
Atc_0300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Atc_0305	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Atc_0306	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Atc_0309	COG0436	Aminotransferase
Atc_0311	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Atc_0313	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Atc_0314	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Atc_0315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Atc_0316	COG4591	ABC-type transport system involved in lipoprotein release permease component
Atc_0317	COG1136	(ABC) transporter
Atc_0319	COG2333	competence protein COMEC
Atc_0319	COG0658	competence protein
Atc_0321	COG0848	biopolymer transport protein
Atc_0324	COG1663	tetraacyldisaccharide 4'-kinase activity
Atc_0325	COG2835	tetraacyldisaccharide 4'-kinase activity
Atc_0326	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Atc_0332	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Atc_0334	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Atc_0337	COG0330	HflC and HflK could
Atc_0339	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Atc_0341	COG2814	Major facilitator Superfamily
Atc_0346	COG0805	protein transport
Atc_0347	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Atc_0348	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Atc_0349	COG0140	phosphoribosyl-ATP diphosphatase activity
Atc_0349	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Atc_0350	COG0107	imidazoleglycerol-phosphate synthase activity
Atc_0351	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Atc_0352	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Atc_0353	COG0131	Imidazoleglycerol-phosphate dehydratase
Atc_0354	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Atc_0356	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Atc_0357	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Atc_0358	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Atc_0360	COG0842	Transport permease protein
Atc_0361	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Atc_0368	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Atc_0370	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Atc_0374	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Atc_0374	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Atc_0374	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Atc_0375	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Atc_0376	COG1660	Displays ATPase and GTPase activities
Atc_0379	COG1376	ErfK ybiS ycfS ynhG family protein
Atc_0381	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Atc_0384	COG0297	glycogen (starch) synthase activity
Atc_0391	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Atc_0392	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Atc_0394	COG2204	response regulator
Atc_0398	COG0497	DNA recombination
Atc_0399	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Atc_0400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Atc_0401	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Atc_0404	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Atc_0409	COG0114	fumarate hydratase activity
Atc_0410	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Atc_0412	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Atc_0412	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Atc_0413	COG0006	proline dipeptidase activity
Atc_0418	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Atc_0421	COG0495	leucyl-tRNA aminoacylation
Atc_0422	COG1534	Rna-binding protein
Atc_0423	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Atc_0425	COG3039	Transposase
Atc_0429	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Atc_0431	COG1061	Type III restriction enzyme res subunit
Atc_0434	COG1002	Type II restriction enzyme, methylase subunits
Atc_0435	COG1002	Type II restriction enzyme, methylase subunits
Atc_0442	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Atc_0443	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Atc_0444	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Atc_0446	COG1294	oxidase, subunit
Atc_0447	COG1271	oxidase subunit
Atc_0449	COG0166	Belongs to the GPI family
Atc_0450	COG1686	Belongs to the peptidase S11 family
Atc_0456	COG0642	Histidine kinase
Atc_0457	COG0745	RESPONSE REGULATOR receiver
Atc_0459	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Atc_0461	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Atc_0464	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Atc_0466	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Atc_0467	COG2890	protein-(glutamine-N5) methyltransferase activity
Atc_0468	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Atc_0469	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Atc_0470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Atc_0472	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Atc_0472	COG0116	Belongs to the methyltransferase superfamily
Atc_0473	COG0552	protein localization to endoplasmic reticulum
Atc_0474	COG2884	Cell division ATP-binding protein ftsE
Atc_0475	COG2177	Part of the ABC transporter FtsEX involved in
Atc_0478	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Atc_0478	COG3264	Mechanosensitive ion channel
Atc_0479	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Atc_0481	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Atc_0482	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Atc_0485	COG4221	oxidoreductase activity
Atc_0489	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Atc_0495	COG1215	transferase activity, transferring glycosyl groups
Atc_0498	COG0513	Belongs to the DEAD box helicase family
Atc_0499	COG1278	Cold shock
Atc_0516	COG1215	transferase activity, transferring glycosyl groups
Atc_0519	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Atc_0522	COG1230	cation diffusion facilitator family transporter
Atc_0523	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Atc_0524	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Atc_0526	COG1449	Belongs to the glycosyl hydrolase 57 family
Atc_0527	COG1940	carbohydrate kinase activity
Atc_0530	COG2733	membrane
Atc_0532	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Atc_0533	COG1702	phosphate starvation-inducible protein PhoH
Atc_0534	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Atc_0535	COG4535	Mg2 and Co2 transporter CorC
Atc_0536	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Atc_0538	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Atc_0541	COG3220	belongs to the UPF0276 family
Atc_0545	COG4232	protein-disulfide reductase activity
Atc_0549	COG2814	Major facilitator Superfamily
Atc_0551	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Atc_0551	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Atc_0555	COG2226	methyltransferase
Atc_0564	COG0033	Phosphoglucomutase
Atc_0567	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Atc_0568	COG0228	four-way junction DNA binding
Atc_0569	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Atc_0570	COG0336	Belongs to the RNA methyltransferase TrmD family
Atc_0571	COG0335	large ribosomal subunit rRNA binding
Atc_0575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Atc_0576	COG3118	belongs to the thioredoxin family
Atc_0579	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Atc_0580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Atc_0581	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Atc_0581	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Atc_0584	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Atc_0585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Atc_0588	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Atc_0590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Atc_0592	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Atc_0594	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Atc_0595	COG0081	regulation of translation
Atc_0596	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Atc_0597	COG0222	ribosome binding
Atc_0598	COG0085	RNA polymerase activity
Atc_0599	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Atc_0600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Atc_0601	COG0049	tRNA binding
Atc_0602	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Atc_0603	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Atc_0604	COG0051	transcription antitermination factor activity, RNA binding
Atc_0605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Atc_0606	COG0088	Forms part of the polypeptide exit tunnel
Atc_0607	COG0089	rRNA binding
Atc_0608	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Atc_0609	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Atc_0610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Atc_0612	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Atc_0613	COG0255	Belongs to the universal ribosomal protein uL29 family
Atc_0614	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Atc_0615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Atc_0616	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Atc_0617	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Atc_0618	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Atc_0619	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Atc_0620	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Atc_0621	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Atc_0622	COG1841	ribosomal large subunit assembly
Atc_0623	COG0200	Binds to the 23S rRNA
Atc_0624	COG0201	protein transport
Atc_0625	COG0563	adenylate kinase activity
Atc_0626	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Atc_0627	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Atc_0628	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Atc_0629	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Atc_0630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Atc_0632	COG0202	RNA polymerase activity
Atc_0633	COG0203	ribosomal protein L17
Atc_0635	COG0629	single-stranded DNA binding
Atc_0638	COG0312	modulator of DNA gyrase
Atc_0639	COG0617	tRNA 3'-terminal CCA addition
Atc_0640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Atc_0642	COG0066	3-isopropylmalate dehydratase activity
Atc_0644	COG0259	pyridoxamine-phosphate oxidase activity
Atc_0645	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Atc_0647	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Atc_0648	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Atc_0649	COG1845	cytochrome c oxidase, subunit III
Atc_0652	COG0109	protoheme IX farnesyltransferase activity
Atc_0653	COG2814	Major facilitator Superfamily
Atc_0654	COG1968	undecaprenyl-diphosphatase activity
Atc_0655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Atc_0658	COG0505	Belongs to the CarA family
Atc_0662	COG0531	amino acid
Atc_0663	COG0142	geranyltranstransferase activity
Atc_0669	COG1573	uracil-dna glycosylase
Atc_0670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Atc_0672	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Atc_0673	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Atc_0674	COG0745	RESPONSE REGULATOR receiver
Atc_0679	COG0811	peptide transport
Atc_0685	COG0768	penicillin binding
Atc_0688	COG0167	dihydroorotate dehydrogenase activity
Atc_0689	COG0408	coproporphyrinogen oxidase activity
Atc_0690	COG0009	L-threonylcarbamoyladenylate synthase
Atc_0691	COG0151	Belongs to the GarS family
Atc_0692	COG0138	bifunctional purine biosynthesis protein purh
Atc_0693	COG1979	alcohol dehydrogenase
Atc_0694	COG0012	GTP binding
Atc_0695	COG0193	aminoacyl-tRNA hydrolase activity
Atc_0696	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Atc_0697	COG0768	penicillin binding
Atc_0700	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Atc_0701	COG1692	metallophosphoesterase
Atc_0704	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Atc_0711	COG0589	response to stress
Atc_0712	COG0442	prolyl-tRNA aminoacylation
Atc_0717	COG1271	oxidase subunit
Atc_0719	COG0531	amino acid
Atc_0721	COG0525	valine-tRNA ligase activity
Atc_0724	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Atc_0728	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Atc_0732	COG1965	Belongs to the frataxin family
Atc_0733	COG0514	ATP-dependent DNA helicase (RecQ)
Atc_0735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Atc_0737	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Atc_0738	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Atc_0739	COG3852	Histidine kinase
Atc_0740	COG2204	response regulator
Atc_0761	COG0822	iron-sulfur transferase activity
Atc_0771	COG3039	Transposase
Atc_0781	COG1216	Glycosyl transferase, family 2
Atc_0781	COG0438	transferase activity, transferring glycosyl groups
Atc_0787	COG3604	Transcriptional regulator
Atc_0790	COG3039	Transposase
Atc_0801	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Atc_0802	COG0268	Binds directly to 16S ribosomal RNA
Atc_0805	COG1187	pseudouridine synthase activity
Atc_0806	COG2957	Belongs to the agmatine deiminase family
Atc_0808	COG0494	nUDIX hydrolase
Atc_0813	COG0254	rRNA binding
Atc_0814	COG0281	malic enzyme
Atc_0816	COG0129	dihydroxy-acid dehydratase activity
Atc_0818	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Atc_0818	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Atc_0820	COG2350	Protein conserved in bacteria
Atc_0821	COG2917	probably involved in intracellular septation
Atc_0824	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Atc_0826	COG1959	2 iron, 2 sulfur cluster binding
Atc_0827	COG1104	cysteine desulfurase activity
Atc_0828	COG0822	iron-sulfur transferase activity
Atc_0829	COG0316	Belongs to the HesB IscA family
Atc_0830	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Atc_0831	COG0443	Heat shock 70 kDa protein
Atc_0834	COG0482	sulfurtransferase activity
Atc_0837	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Atc_0838	COG0704	Plays a role in the regulation of phosphate uptake
Atc_0841	COG0052	Belongs to the universal ribosomal protein uS2 family
Atc_0842	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Atc_0843	COG0528	UMP kinase activity
Atc_0845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Atc_0846	COG0575	Belongs to the CDS family
Atc_0847	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Atc_0851	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Atc_0852	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Atc_0853	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Atc_0856	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Atc_0857	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Atc_0859	COG0825	malonyl-CoA metabolic process
Atc_0860	COG0037	tRNA processing
Atc_0869	COG1132	(ABC) transporter
Atc_0874	COG1592	Rubrerythrin
Atc_0877	COG1570	exodeoxyribonuclease VII activity
Atc_0878	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Atc_0883	COG0741	lytic transglycosylase activity
Atc_0885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Atc_0887	COG1121	(ABC) transporter
Atc_0888	COG2223	nitrite transmembrane transporter activity
Atc_0889	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Atc_0904	COG3039	Transposase
Atc_0906	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Atc_0907	COG0616	signal peptide processing
Atc_0908	COG0314	molybdopterin synthase activity
Atc_0909	COG1666	GTP binding
Atc_0912	COG0509	glycine decarboxylation via glycine cleavage system
Atc_0913	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Atc_0915	COG0714	Associated with various cellular activities
Atc_0918	COG1132	(ABC) transporter
Atc_0919	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Atc_0921	COG0450	alkyl hydroperoxide reductase
Atc_0923	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Atc_0926	COG1850	ribulose-bisphosphate carboxylase activity
Atc_0927	COG4451	ribulose bisphosphate carboxylase, small
Atc_0939	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Atc_0948	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Atc_0948	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Atc_0948	COG0506	proline dehydrogenase activity
Atc_0950	COG2205	protein histidine kinase activity
Atc_0951	COG0640	Transcriptional regulator
Atc_0952	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Atc_0953	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Atc_0963	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Atc_0967	COG2814	Major facilitator Superfamily
Atc_0968	COG1686	Belongs to the peptidase S11 family
Atc_0972	COG0418	dihydroorotase activity
Atc_0975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Atc_0979	COG0697	spore germination
Atc_0980	COG1902	pentaerythritol trinitrate reductase activity
Atc_0989	COG0322	excinuclease ABC activity
Atc_1000	COG0557	exoribonuclease II activity
Atc_1005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Atc_1006	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Atc_1010	COG1295	ribonuclease BN
Atc_1012	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Atc_1013	COG0416	fatty acid biosynthetic process
Atc_1014	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Atc_1015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Atc_1016	COG1028	Short-chain dehydrogenase reductase Sdr
Atc_1017	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Atc_1018	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Atc_1020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Atc_1021	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Atc_1022	COG0470	DNA polymerase III
Atc_1038	COG0583	DNA-binding transcription factor activity
Atc_1039	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Atc_1040	COG3002	Belongs to the UPF0753 family
Atc_1044	COG0129	dihydroxy-acid dehydratase activity
Atc_1045	COG0009	L-threonylcarbamoyladenylate synthase
Atc_1047	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Atc_1053	COG3885	ferrous iron binding
Atc_1053	COG2078	PFAM AMMECR1 domain protein
Atc_1054	COG1355	regulation of microtubule-based process
Atc_1062	COG2433	Pfam Transposase IS66
Atc_1063	COG3436	PFAM IS66 Orf2 family protein
Atc_1065	COG1484	DNA-dependent DNA replication
Atc_1068	COG4232	protein-disulfide reductase activity
Atc_1070	COG1595	DNA-templated transcription, initiation
Atc_1072	COG3220	belongs to the UPF0276 family
Atc_1077	COG0842	Transport permease protein
Atc_1078	COG0842	Transport permease protein
Atc_1079	COG1131	(ABC) transporter
Atc_1081	COG1538	Outer membrane efflux protein
Atc_1088	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Atc_1089	COG3002	Belongs to the UPF0753 family
Atc_1090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Atc_1091	COG0583	DNA-binding transcription factor activity
Atc_1092	COG3706	GGDEF domain
Atc_1093	COG2353	YceI-like domain
Atc_1094	COG0655	NAD(P)H dehydrogenase (quinone) activity
Atc_1095	COG1733	regulation of RNA biosynthetic process
Atc_1116	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Atc_1121	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Atc_1122	COG3707	response regulator
Atc_1123	COG1648	precorrin-2 dehydrogenase activity
Atc_1123	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Atc_1124	COG0243	molybdopterin cofactor binding
Atc_1125	COG2146	nitrite reductase [NAD(P)H] activity
Atc_1126	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Atc_1128	COG2223	nitrite transmembrane transporter activity
Atc_1129	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Atc_1129	COG1116	anion transmembrane transporter activity
Atc_1131	COG3039	Transposase
Atc_1141	COG1484	DNA-dependent DNA replication
Atc_1152	COG0629	single-stranded DNA binding
Atc_1165	COG4962	Type ii secretion system protein e
Atc_1171	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Atc_1180	COG3451	type IV secretory pathway VirB4
Atc_1182	COG1598	PFAM Uncharacterised protein family UPF0150
Atc_1201	COG3701	Conjugal transfer protein
Atc_1202	COG3504	Conjugal transfer protein
Atc_1203	COG2948	multi-organism process
Atc_1205	COG1192	Involved in chromosome partitioning
Atc_1206	COG1475	DNA binding
Atc_1209	COG3561	AntA/AntB antirepressor
Atc_1210	COG3561	AntA/AntB antirepressor
Atc_1224	COG1199	ATP-dependent helicase activity
Atc_1229	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Atc_1229	COG2755	lipolytic protein G-D-S-L family
Atc_1253	COG3093	addiction module antidote protein HigA
Atc_1257	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Atc_1269	COG0741	lytic transglycosylase activity
Atc_1294	COG0582	viral genome integration into host DNA
Atc_1296	COG0582	viral genome integration into host DNA
Atc_1301	COG0729	surface antigen
Atc_1302	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Atc_1303	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Atc_1304	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Atc_1305	COG0004	ammonium transporteR
Atc_1306	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Atc_1306	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Atc_1307	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Atc_1308	COG2239	Acts as a magnesium transporter
Atc_1309	COG0802	atpase or kinase
Atc_1311	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Atc_1315	COG0393	Putative heavy-metal-binding
Atc_1318	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Atc_1320	COG0429	hydrolase of the alpha beta-hydrolase fold
Atc_1322	COG2373	Large extracellular alpha-helical protein
Atc_1323	COG4953	penicillin-binding protein 1C
Atc_1324	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Atc_1325	COG0508	dehydrogenase complex catalyzes the overall conversion of
Atc_1326	COG0022	dehydrogenase e1 component
Atc_1327	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Atc_1329	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Atc_1330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Atc_1330	COG0574	Belongs to the PEP-utilizing enzyme family
Atc_1333	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Atc_1334	COG2171	N-acyltransferase activity
Atc_1338	COG0402	S-adenosylhomocysteine deaminase activity
Atc_1340	COG0791	NLP P60 protein
Atc_1340	COG1388	LysM domain
Atc_1347	COG2271	Major facilitator Superfamily
Atc_1348	COG0438	transferase activity, transferring glycosyl groups
Atc_1350	COG0745	RESPONSE REGULATOR receiver
Atc_1351	COG0811	peptide transport
Atc_1357	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Atc_1362	COG1566	PFAM secretion protein HlyD family protein
Atc_1364	COG2132	Multicopper oxidase
Atc_1365	COG0105	UTP biosynthetic process
Atc_1366	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Atc_1369	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Atc_1370	COG0124	histidyl-tRNA synthetase
Atc_1372	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Atc_1373	COG1160	GTP binding
Atc_1383	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Atc_1384	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Atc_1387	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Atc_1389	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Atc_1390	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Atc_1391	COG0287	Prephenate dehydrogenase
Atc_1392	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Atc_1393	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Atc_1395	COG0776	regulation of translation
Atc_1397	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Atc_1399	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Atc_1400	COG0544	peptidyl-prolyl cis-trans isomerase activity
Atc_1401	COG0740	serine-type endopeptidase activity
Atc_1402	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Atc_1403	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Atc_1404	COG0776	regulation of translation
Atc_1405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Atc_1410	COG5001	Diguanylate cyclase
Atc_1410	COG3447	MASE1 domain protein
Atc_1410	COG5002	protein histidine kinase activity
Atc_1417	COG5002	protein histidine kinase activity
Atc_1417	COG5001	Diguanylate cyclase
Atc_1417	COG3447	MASE1 domain protein
Atc_1428	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Atc_1429	COG0215	cysteine-tRNA ligase activity
Atc_1431	COG1530	ribonuclease E activity
Atc_1433	COG0546	phosphoglycolate phosphatase activity
Atc_1435	COG3842	ATPase activity
Atc_1437	COG0446	pyridine nucleotide-disulphide oxidoreductase
Atc_1440	COG1028	Short-chain dehydrogenase reductase Sdr
Atc_1441	COG0616	signal peptide processing
Atc_1442	COG0667	Aldo Keto reductase
Atc_1445	COG0840	transmembrane signaling receptor activity
Atc_1446	COG0784	Response regulator, receiver
Atc_1446	COG0835	chemotaxis
Atc_1449	COG0643	Histidine kinase
Atc_1449	COG2198	Histidine kinase
Atc_1451	COG0745	RESPONSE REGULATOR receiver
Atc_1455	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Atc_1460	COG1815	bacterial-type flagellum-dependent cell motility
Atc_1461	COG1558	bacterial-type flagellum-dependent cell motility
Atc_1462	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Atc_1463	COG1749	Flagellar hook protein flgE
Atc_1465	COG4786	Flagellar basal body rod
Atc_1466	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Atc_1467	COG1706	bacterial-type flagellum-dependent cell motility
Atc_1468	COG3951	Flagellar rod assembly protein muramidase FlgJ
Atc_1468	COG1705	Flagellar rod assembly protein muramidase FlgJ
Atc_1470	COG1256	bacterial-type flagellum assembly
Atc_1474	COG1216	Glycosyl transferase, family 2
Atc_1474	COG0438	transferase activity, transferring glycosyl groups
Atc_1481	COG3852	Histidine kinase
Atc_1482	COG2204	response regulator
Atc_1485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Atc_1493	COG1338	Plays a role in the flagellum-specific transport system
Atc_1494	COG1987	bacterial-type flagellum assembly
Atc_1497	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Atc_1499	COG0455	bacterial-type flagellum organization
Atc_1500	COG1191	sigma factor activity
Atc_1501	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Atc_1502	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Atc_1503	COG0670	Belongs to the BI1 family
Atc_1507	COG0277	FAD linked oxidase domain protein
Atc_1508	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Atc_1509	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Atc_1510	COG1428	Deoxynucleoside kinase
Atc_1512	COG0617	tRNA 3'-terminal CCA addition
Atc_1515	COG0519	Catalyzes the synthesis of GMP from XMP
Atc_1517	COG1017	nitric oxide dioxygenase activity
Atc_1517	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Atc_1521	COG3189	MarR family transcriptional regulator
Atc_1522	COG0477	Major facilitator Superfamily
Atc_1525	COG2814	Major facilitator Superfamily
Atc_1528	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Atc_1533	COG1105	Belongs to the carbohydrate kinase PfkB family
Atc_1534	COG0280	phosphate acetyltransferase
Atc_1543	COG1914	H( )-stimulated, divalent metal cation uptake system
Atc_1545	COG1285	pathogenesis
Atc_1548	COG3657	addiction module killer protein
Atc_1549	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Atc_1551	COG3706	GGDEF domain
Atc_1552	COG3706	GGDEF domain
Atc_1552	COG0745	RESPONSE REGULATOR receiver
Atc_1556	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Atc_1559	COG5002	protein histidine kinase activity
Atc_1559	COG5001	Diguanylate cyclase
Atc_1559	COG3447	MASE1 domain protein
Atc_1565	COG1484	DNA-dependent DNA replication
Atc_1567	COG3039	Transposase
Atc_1568	COG3039	Transposase
Atc_1569	COG3039	Transposase
Atc_1574	COG3436	PFAM IS66 Orf2 family protein
Atc_1575	COG2433	Pfam Transposase IS66
Atc_1583	COG1294	oxidase, subunit
Atc_1584	COG1271	oxidase subunit
Atc_1585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Atc_1587	COG0477	Major facilitator Superfamily
Atc_1590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Atc_1591	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Atc_1593A	COG0745	RESPONSE REGULATOR receiver
Atc_1595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Atc_1600	COG3039	Transposase
Atc_1603	COG1271	oxidase subunit
Atc_1604	COG1294	oxidase, subunit
Atc_1606	COG0243	molybdopterin cofactor binding
Atc_1607	COG0437	4 iron, 4 sulfur cluster binding
Atc_1608	COG3302	dmso reductase anchor subunit
Atc_1614	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Atc_1618	COG3436	PFAM IS66 Orf2 family protein
Atc_1619	COG2433	Pfam Transposase IS66
Atc_1621	COG0583	DNA-binding transcription factor activity
Atc_1629	COG3039	Transposase
Atc_1631	COG2433	Pfam Transposase IS66
Atc_1632	COG3436	PFAM IS66 Orf2 family protein
Atc_1634	COG1113	amino acid transport
Atc_1636	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Atc_1642	COG2814	Major facilitator Superfamily
Atc_1643	COG4654	Cytochrome c, class I
Atc_1647	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Atc_1650	COG0243	molybdopterin cofactor binding
Atc_1651	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Atc_1652	COG1166	arginine decarboxylase activity
Atc_1653	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Atc_1654	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Atc_1656	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Atc_1657	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Atc_1661	COG1850	ribulose-bisphosphate carboxylase activity
Atc_1668	COG0651	ATP synthesis coupled electron transport
Atc_1669	COG0649	NAD binding
Atc_1669	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_1669	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_1670	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_1674	COG0076	glutamate decarboxylase activity
Atc_1675	COG0163	prenyltransferase activity
Atc_1676	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Atc_1678	COG2022	thiamine diphosphate biosynthetic process
Atc_1684	COG2137	regulation of response to DNA damage stimulus
Atc_1685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Atc_1686	COG1058	Belongs to the CinA family
Atc_1686	COG1546	Belongs to the CinA family
Atc_1688	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Atc_1691	COG1489	DNA binding
Atc_1692	COG0024	Methionine aminopeptidase
Atc_1694	COG2915	High frequency lysogenization protein hflD homolog
Atc_1697	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Atc_1699	COG1196	nuclear chromosome segregation
Atc_1700	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Atc_1702	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Atc_1704	COG1187	pseudouridine synthase activity
Atc_1705	COG0446	pyridine nucleotide-disulphide oxidoreductase
Atc_1707	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Atc_1708	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Atc_1709	COG0180	Tryptophanyl-tRNA synthetase
Atc_1710	COG1994	Peptidase M50
Atc_1711	COG0009	L-threonylcarbamoyladenylate synthase
Atc_1712	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Atc_1714	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Atc_1714	COG3264	Mechanosensitive ion channel
Atc_1715	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Atc_1716	COG0531	amino acid
Atc_1718	COG1716	ATPase activity
Atc_1718	COG5001	Diguanylate cyclase
Atc_1719	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Atc_1719	COG2205	protein histidine kinase activity
Atc_1720	COG0587	DNA-directed DNA polymerase activity
Atc_1723	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Atc_1725	COG2860	membrane
Atc_1727	COG0438	transferase activity, transferring glycosyl groups
Atc_1728	COG0438	transferase activity, transferring glycosyl groups
Atc_1729	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Atc_1733	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Atc_1734	COG0196	riboflavin kinase activity
Atc_1735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Atc_1736	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Atc_1740	COG4178	(ABC) transporter
Atc_1742	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Atc_1743	COG0860	N-Acetylmuramoyl-L-alanine amidase
Atc_1744	COG3118	belongs to the thioredoxin family
Atc_1746	COG0425	Belongs to the sulfur carrier protein TusA family
Atc_1746	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Atc_1751	COG0640	Transcriptional regulator
Atc_1752	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Atc_1755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Atc_1756	COG0084	hydrolase, TatD family'
Atc_1757	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Atc_1758	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Atc_1762	COG1183	phosphatidylcholine synthase activity
Atc_1763	COG0688	phosphatidylethanolamine metabolic process
Atc_1764	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Atc_1766	COG0028	Belongs to the TPP enzyme family
Atc_1767	COG1193	negative regulation of DNA recombination
Atc_1769	COG0432	Pfam Uncharacterised protein family UPF0047
Atc_1770	COG0590	tRNA wobble adenosine to inosine editing
Atc_1776	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Atc_1777	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Atc_1778	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Atc_1779	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Atc_1780	COG0069	glutamate synthase activity
Atc_1780	COG0070	glutamate synthase
Atc_1780	COG0067	glutamate synthase
Atc_1781	COG0493	'glutamate synthase
Atc_1782	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Atc_1786	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Atc_1787	COG0330	HflC and HflK could
Atc_1788	COG0330	HflC and HflK could
Atc_1789	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Atc_1790	COG1923	regulation of RNA biosynthetic process
Atc_1791	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Atc_1792	COG0424	maF-like protein
Atc_1801	COG2433	Pfam Transposase IS66
Atc_1802	COG3436	PFAM IS66 Orf2 family protein
Atc_1807	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Atc_1809	COG0640	Transcriptional regulator
Atc_1814	COG1484	DNA-dependent DNA replication
Atc_1820	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Atc_1822	COG0322	excinuclease ABC activity
Atc_1824	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Atc_1826	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Atc_1827	COG0148	phosphopyruvate hydratase activity
Atc_1828	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Atc_1829	COG0504	CTP synthase activity
Atc_1854	COG0513	Belongs to the DEAD box helicase family
Atc_1858	COG0505	Belongs to the CarA family
Atc_1860	COG0004	ammonium transporteR
Atc_1867	COG3852	Histidine kinase
Atc_1881	COG1937	Protein conserved in bacteria
Atc_1883	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Atc_1888	COG2217	Heavy metal translocating P-type atpase
Atc_1898	COG2226	methyltransferase
Atc_1902	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Atc_1902	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Atc_1904	COG2814	Major facilitator Superfamily
Atc_1908	COG4232	protein-disulfide reductase activity
Atc_1912	COG3220	belongs to the UPF0276 family
Atc_1915	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Atc_1916	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Atc_1921	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Atc_1921	COG1017	nitric oxide dioxygenase activity
Atc_1925	COG0509	glycine decarboxylation via glycine cleavage system
Atc_1932	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Atc_1935	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Atc_1936	COG1140	nitrate reductase beta subunit
Atc_1936A	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Atc_1937	COG2181	nitrate reductase activity
Atc_1939	COG2223	nitrite transmembrane transporter activity
Atc_1940	COG3189	MarR family transcriptional regulator
Atc_1947	COG0477	Major facilitator Superfamily
Atc_1948	COG0583	DNA-binding transcription factor activity
Atc_1955	COG0084	hydrolase, TatD family'
Atc_1956	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Atc_1958	COG0628	permease
Atc_1959	COG0613	PHP domain protein
Atc_1961	COG0628	permease
Atc_1964	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Atc_1967	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Atc_1968	COG1758	RNA polymerase activity
Atc_1970	COG1561	YicC-like family, N-terminal region
Atc_1971	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Atc_1973	COG4232	protein-disulfide reductase activity
Atc_1974	COG1324	tolerance protein
Atc_1980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Atc_1982	COG0582	viral genome integration into host DNA
Atc_2005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Atc_2022	COG3561	AntA/AntB antirepressor
Atc_2029	COG3451	type IV secretory pathway VirB4
Atc_2042	COG4964	Belongs to the GSP D family
Atc_2045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Atc_2054	COG2805	Type II/IV secretion system protein
Atc_2059	COG0741	lytic transglycosylase activity
Atc_2072	COG3077	Addiction module antitoxin, RelB DinJ family
Atc_2073	COG3041	Addiction module toxin RelE StbE family
Atc_2085	COG1484	DNA-dependent DNA replication
Atc_2087	COG0210	DNA helicase
Atc_2094	COG0741	lytic transglycosylase activity
Atc_2099	COG0629	single-stranded DNA binding
Atc_2104	COG4584	PFAM Integrase catalytic
Atc_2105	COG1484	DNA-dependent DNA replication
Atc_2120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Atc_2143	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Atc_2144	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Atc_2145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Atc_2148	COG3025	triphosphatase activity
Atc_2150	COG0308	aminopeptidase N
Atc_2152	COG0542	response to heat
Atc_2153	COG2211	Major facilitator Superfamily
Atc_2154	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Atc_2155	COG1469	GTP cyclohydrolase I activity
Atc_2156	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Atc_2157	COG0142	geranyltranstransferase activity
Atc_2159	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Atc_2160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Atc_2161	COG1862	Preprotein translocase
Atc_2162	COG0343	queuine tRNA-ribosyltransferase activity
Atc_2163	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Atc_2164	COG1253	flavin adenine dinucleotide binding
Atc_2167	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Atc_2169	COG0285	dihydrofolate synthase activity
Atc_2170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Atc_2171	COG0159	tryptophan synthase activity
Atc_2172	COG0133	tryptophan synthase activity
Atc_2173	COG0135	phosphoribosylanthranilate isomerase activity
Atc_2174	COG0101	tRNA pseudouridine synthase activity
Atc_2176	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Atc_2179	COG0746	molybdenum cofactor guanylyltransferase activity
Atc_2180	COG1763	Mo-molybdopterin cofactor biosynthetic process
Atc_2181	COG0303	'Molybdopterin
Atc_2182	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Atc_2186	COG0415	Belongs to the DNA photolyase family
Atc_2188	COG1294	oxidase, subunit
Atc_2189	COG1271	oxidase subunit
Atc_2191	COG0842	Transport permease protein
Atc_2192	COG0842	Transport permease protein
Atc_2193	COG1131	(ABC) transporter
Atc_2195	COG2814	Major facilitator Superfamily
Atc_2196	COG0589	response to stress
Atc_2198	COG0047	phosphoribosylformylglycinamidine synthase activity
Atc_2198	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Atc_2199	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Atc_2200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Atc_2202	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Atc_2204	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Atc_2205	COG0459	protein refolding
Atc_2207	COG0529	Catalyzes the synthesis of activated sulfate
Atc_2207	COG2046	Belongs to the sulfate adenylyltransferase family
Atc_2209	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Atc_2210	COG3258	Cytochrome c
Atc_2213	COG1333	cytochrome c biogenesis protein
Atc_2215	COG0737	Belongs to the 5'-nucleotidase family
Atc_2220	COG1845	cytochrome c oxidase, subunit III
Atc_2221	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Atc_2222	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Atc_2223	COG1484	DNA-dependent DNA replication
Atc_2226	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Atc_2227	COG0154	amidase activity
Atc_2228	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Atc_2235	COG3394	polysaccharide catabolic process
Atc_2236	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Atc_2238	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Atc_2240	COG1657	PFAM Prenyltransferase squalene oxidase
Atc_2241	COG1562	ergosterol biosynthetic process
Atc_2242	COG1136	(ABC) transporter
Atc_2246	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Atc_2249	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Atc_2250	COG1127	ABC transporter
Atc_2251	COG1538	Outer membrane efflux protein
Atc_2259	COG4115	mRNA cleavage
Atc_2260	COG2161	toxin-antitoxin pair type II binding
Atc_2261	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Atc_2262	COG0358	DNA primase activity
Atc_2263	COG1193	negative regulation of DNA recombination
Atc_2264	COG1610	YqeY-like protein
Atc_2265	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Atc_2267	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Atc_2268	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Atc_2270	COG0326	Molecular chaperone. Has ATPase activity
Atc_2271	COG2363	Small membrane protein
Atc_2277	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Atc_2279	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Atc_2281	COG1271	oxidase subunit
Atc_2282	COG1294	oxidase, subunit
Atc_2287	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Atc_2291	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Atc_2292	COG0037	tRNA processing
Atc_2293	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Atc_2293	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Atc_2295	COG0736	holo-[acyl-carrier-protein] synthase activity
Atc_2296	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Atc_2297	COG1381	Involved in DNA repair and RecF pathway recombination
Atc_2298	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Atc_2302	COG0481	GTPase activity
Atc_2303	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Atc_2306	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Atc_2309	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Atc_2310	COG4988	ABC transporter
Atc_2316	COG1214	PFAM Peptidase M22, glycoprotease
Atc_2317	COG1199	ATP-dependent helicase activity
Atc_2318	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Atc_2319	COG0791	NLP P60 protein
Atc_2325	COG0586	Pfam SNARE associated Golgi protein
Atc_2342	COG0095	Lipoate-protein ligase
Atc_2344	COG0509	glycine decarboxylation via glycine cleavage system
Atc_2346	COG0509	glycine decarboxylation via glycine cleavage system
Atc_2347	COG2048	Heterodisulfide reductase, subunit B
Atc_2353	COG2210	Belongs to the sulfur carrier protein TusA family
Atc_2354	COG0425	Belongs to the sulfur carrier protein TusA family
Atc_2355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Atc_2356	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Atc_2357	COG3302	dmso reductase anchor subunit
Atc_2358	COG0437	4 iron, 4 sulfur cluster binding
Atc_2359	COG0243	molybdopterin cofactor binding
Atc_2361	COG0315	cyclic pyranopterin monophosphate synthase activity
Atc_2363	COG5000	phosphorelay sensor kinase activity
Atc_2369	COG3439	Domain of unknown function DUF302
Atc_2370	COG0737	Belongs to the 5'-nucleotidase family
Atc_2371	COG1077	Cell shape determining protein MreB Mrl
Atc_2372	COG1792	Involved in formation and maintenance of cell shape
Atc_2374	COG0768	penicillin binding
Atc_2375	COG0772	Belongs to the SEDS family
Atc_2376	COG1686	Belongs to the peptidase S11 family
Atc_2378	COG0321	lipoyl(octanoyl) transferase activity
Atc_2379	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Atc_2389	COG0751	glycine-tRNA ligase activity
Atc_2390	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Atc_2396	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Atc_2397	COG2154	pterin-4-alpha-carbinolamine dehydratase
Atc_2398	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Atc_2400	COG3023	N-Acetylmuramoyl-L-alanine amidase
Atc_2402	COG0450	alkyl hydroperoxide reductase
Atc_2403	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Atc_2411	COG3039	Transposase
Atc_2412	COG0247	lactate metabolic process
Atc_2413	COG0277	FAD linked oxidase domain protein
Atc_2414	COG0277	FAD linked oxidase domain protein
Atc_2417	COG1414	Transcriptional regulator
Atc_2420	COG3604	Transcriptional regulator
Atc_2426	COG0242	peptide deformylase activity
Atc_2428	COG0235	Class ii aldolase
Atc_2429	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
Atc_2431	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Atc_2433	COG0564	pseudouridine synthase activity
Atc_2436	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Atc_2436	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Atc_2439	COG0045	succinate-CoA ligase (ADP-forming) activity
Atc_2440	COG0538	isocitrate dehydrogenase activity
Atc_2441	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Atc_2443	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Atc_2444	COG1388	LysM domain
Atc_2444	COG0741	lytic transglycosylase activity
Atc_2446	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Atc_2448	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Atc_2449	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Atc_2451	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Atc_2452	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Atc_2453	COG0137	argininosuccinate synthase activity
Atc_2455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Atc_2456	COG0328	RNA-DNA hybrid ribonuclease activity
Atc_2457	COG2226	methyltransferase
Atc_2459	COG0612	Peptidase, M16
Atc_2460	COG1185	polyribonucleotide nucleotidyltransferase activity
Atc_2461	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Atc_2462	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Atc_2463	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Atc_2464	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Atc_2465	COG0195	Participates in both transcription termination and antitermination
Atc_2467	COG0779	Required for maturation of 30S ribosomal subunits
Atc_2470	COG1266	CAAX protease self-immunity
Atc_2472	COG1388	LysM domain
Atc_2472	COG1376	ErfK ybiS ycfS ynhG family protein
Atc_2474	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Atc_2475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Atc_2477	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Atc_2479	COG0492	ferredoxin-NADP+ reductase activity
Atc_2481	COG1193	negative regulation of DNA recombination
Atc_2483	COG0585	pseudouridine synthase activity
Atc_2484	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Atc_2485	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Atc_2486	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Atc_2487	COG0560	Phosphoserine phosphatase
Atc_2488	COG0678	peroxiredoxin activity
Atc_2488	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Atc_2489	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Atc_2495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Atc_2496	COG2003	Belongs to the UPF0758 family
Atc_2497	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Atc_2498	COG0756	dUTP diphosphatase activity
Atc_2500	COG0717	Belongs to the dCTP deaminase family
Atc_2501	COG0489	protein tyrosine kinase activity
Atc_2503	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Atc_2504	COG0484	heat shock protein binding
Atc_2505	COG0443	Heat shock 70 kDa protein
Atc_2506	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Atc_2507	COG1420	regulation of RNA biosynthetic process
Atc_2508	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Atc_2509	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Atc_2510	COG3046	protein related to deoxyribodipyrimidine photolyase
Atc_2517	COG1028	Short-chain dehydrogenase reductase Sdr
Atc_2527	COG4221	oxidoreductase activity
Atc_2529	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Atc_2531	COG0312	modulator of DNA gyrase
Atc_2532	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Atc_2533	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Atc_2534	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Atc_2535	COG0149	triose-phosphate isomerase activity
Atc_2536	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Atc_2538	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_2539	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_2540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_2541	COG0649	NAD binding
Atc_2542	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Atc_2544	COG1034	ATP synthesis coupled electron transport
Atc_2545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Atc_2546	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_2548	COG0713	ATP synthesis coupled electron transport
Atc_2551	COG1007	ATP synthesis coupled electron transport
Atc_2553	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Atc_2554	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Atc_2555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Atc_2556	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Atc_2557	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Atc_2558	COG0072	phenylalanine-tRNA ligase activity
Atc_2559	COG0776	regulation of translation
Atc_2561	COG1116	anion transmembrane transporter activity
Atc_2563	COG0469	pyruvate kinase activity
Atc_2563	COG0469	pyruvate kinase activity
Atc_2568	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_2569	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_2569	COG0649	NAD binding
Atc_2569	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_2570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_2570	COG0649	NAD binding
Atc_2570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_2571	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Atc_2573	COG1034	ATP synthesis coupled electron transport
Atc_2574	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Atc_2575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Atc_2578	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Atc_2580	COG1007	ATP synthesis coupled electron transport
Atc_2582	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Atc_2587	COG0735	belongs to the Fur family
Atc_2588	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Atc_2590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Atc_2591	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Atc_2594	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Atc_2597	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Atc_2598	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Atc_2609	COG1872	DUF167
Atc_2610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Atc_2612	COG1566	PFAM secretion protein HlyD family protein
Atc_2614	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Atc_2619	COG0543	2 iron, 2 sulfur cluster binding
Atc_2619	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Atc_2620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Atc_2621	COG0390	transport system, permease component
Atc_2622	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Atc_2623	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Atc_2624	COG0501	Belongs to the peptidase M48B family
Atc_2625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Atc_2626	COG2226	methyltransferase
Atc_2627	COG0596	Alpha beta hydrolase
Atc_2628	COG0156	8-amino-7-oxononanoate synthase activity
Atc_2629	COG1040	competence protein
Atc_2630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Atc_2631	COG0477	Major facilitator Superfamily
Atc_2632	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Atc_2633	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Atc_2635	COG0859	PFAM glycosyl transferase family 9
Atc_2640	COG0438	transferase activity, transferring glycosyl groups
Atc_2642	COG0463	Glycosyl transferase, family 2
Atc_2643	COG0494	nUDIX hydrolase
Atc_2644	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Atc_2645	COG0653	protein targeting
Atc_2646	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Atc_2647	COG0625	glutathione transferase activity
Atc_2650	COG2001	Belongs to the MraZ family
Atc_2651	COG0275	rRNA processing
Atc_2655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Atc_2656	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Atc_2657	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Atc_2658	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Atc_2659	COG0772	Belongs to the SEDS family
Atc_2660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Atc_2661	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Atc_2662	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Atc_2663	COG1181	Belongs to the D-alanine--D-alanine ligase family
Atc_2664	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Atc_2667	COG0058	SHG alpha-glucan phosphorylase activity
Atc_2668	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Atc_2670	COG0793	Belongs to the peptidase S41A family
Atc_2671	COG0693	protein deglycase activity
Atc_2672	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Atc_2673	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Atc_2674	COG0542	response to heat
Atc_2675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Atc_2676	COG2813	Specifically methylates the guanine in position
Atc_2676	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Atc_2677	COG0625	glutathione transferase activity
Atc_2679	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Atc_2686	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Atc_2688	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Atc_2689	COG0768	penicillin binding
Atc_2691	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Atc_2693	COG0823	Involved in the tonB-independent uptake of proteins
Atc_2695	COG0583	DNA-binding transcription factor activity
Atc_2697	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Atc_2698	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Atc_2699	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Atc_2700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Atc_2701	COG3047	cAMP biosynthetic process
Atc_2701	COG2885	chlorophyll binding
Atc_2702	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Atc_2703	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Atc_2706	COG0165	Argininosuccinate lyase
Atc_2709	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Atc_2711	COG1611	Belongs to the LOG family
Atc_2712	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Atc_2712	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Atc_2713	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Atc_2714	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Atc_2715	COG1333	cytochrome c biogenesis protein
Atc_2716	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Atc_2718	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Atc_2720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Atc_2721	COG3386	PFAM SMP-30 Gluconolaconase
Atc_2723	COG2814	Major facilitator Superfamily
Atc_2724	COG0488	(ABC) transporter
Atc_2739	COG3179	chitinase
Atc_2743	COG3179	chitinase
Atc_2749	COG4964	Belongs to the GSP D family
Atc_2762	COG0792	nuclease activity
Atc_2763	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Atc_2764	COG0277	FAD linked oxidase domain protein
Atc_2766	COG0859	PFAM glycosyl transferase family 9
Atc_2769	COG0583	DNA-binding transcription factor activity
Atc_2774	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Atc_2776	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Atc_2777	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Atc_2779	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Atc_2780	COG2833	Protein of unknown function (DUF455)
Atc_2782	COG0386	Belongs to the glutathione peroxidase family
Atc_2788	COG2095	MarC family integral membrane protein
Atc_2790	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Atc_2791	COG1051	belongs to the nudix hydrolase family
Atc_2792	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Atc_2794	COG0217	transcriptional regulatory protein
Atc_2795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Atc_2796	COG0632	four-way junction helicase activity
Atc_2797	COG2255	four-way junction helicase activity
Atc_2798	COG0824	Thioesterase
Atc_2802	COG0823	Involved in the tonB-independent uptake of proteins
Atc_2803	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Atc_2804	COG0602	queuosine metabolic process
Atc_2807	COG0181	hydroxymethylbilane synthase activity
Atc_2809	COG0113	porphobilinogen synthase activity
Atc_2811	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Atc_2812	COG0477	Major facilitator Superfamily
Atc_2813	COG1272	protein, Hemolysin III
Atc_2818	COG1530	ribonuclease E activity
Atc_2819	COG0424	maF-like protein
Atc_2822	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Atc_2824	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Atc_2827	COG1560	Kdo2-lipid A biosynthetic process
Atc_2829	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Atc_2830	COG0706	membrane insertase activity
Atc_2831	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Atc_2832	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Atc_2833	COG0594	ribonuclease P activity
Atc_2834	COG1127	ABC transporter
Atc_2835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Atc_2836	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Atc_2839	COG1131	(ABC) transporter
Atc_2840	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Atc_2841	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Atc_2843	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Atc_2846	COG0018	arginyl-trna synthetase
Atc_2847	COG0477	Major facilitator Superfamily
Atc_2848	COG0583	DNA-binding transcription factor activity
Atc_2850	COG0708	Exodeoxyribonuclease III
Atc_2852	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Atc_2853	COG0625	glutathione transferase activity
Atc_2854	COG0708	Exodeoxyribonuclease III
Atc_2855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Atc_2856	COG1047	Peptidyl-prolyl cis-trans
Atc_2857	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Atc_2858	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Atc_2862	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Atc_2863	COG0237	dephospho-CoA kinase activity
Atc_2864	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Atc_2865	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Atc_2868	COG0739	heme binding
Atc_2868	COG1196	nuclear chromosome segregation
Atc_2868	COG0741	lytic transglycosylase activity
Atc_2869	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Atc_2871	COG2264	protein methyltransferase activity
Atc_2872	COG0439	Biotin carboxylase
Atc_2873	COG0511	ligase activity, forming carbon-carbon bonds
Atc_2874	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Atc_2875	COG0778	Nitroreductase
Atc_2877	COG1555	photosystem II stabilization
Atc_2878	COG0537	adenosine 5'-monophosphoramidase activity
Atc_2879	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Atc_2880	COG0352	thiamine-phosphate diphosphorylase activity
Atc_2881	COG0351	phosphomethylpyrimidine kinase
Atc_2883	COG1028	Short-chain dehydrogenase reductase Sdr
Atc_2p10	COG1192	Involved in chromosome partitioning
Atc_3p	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Atc_3p07	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Atc_3p21	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Atc_3p26	COG1192	Involved in chromosome partitioning
Atc_m001	COG0811	peptide transport
Atc_m006	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Atc_m009	COG2801	Transposase and inactivated derivatives
Atc_m013	COG1484	DNA-dependent DNA replication
Atc_m014	COG4584	PFAM Integrase catalytic
Atc_m017	COG4372	Transposase
Atc_m030	COG0583	DNA-binding transcription factor activity
Atc_m032	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Atc_m037	COG0776	regulation of translation
Atc_m039	COG3668	Plasmid stabilization system
Atc_m048	COG0210	DNA helicase
Atc_m055	COG2336	PFAM SpoVT AbrB
Atc_m060	COG0517	IMP dehydrogenase activity
Atc_m082	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Atc_m088	COG2217	Heavy metal translocating P-type atpase
Atc_m089	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Atc_m094	COG2995	paraquat-inducible protein a
Atc_m104	COG1484	DNA-dependent DNA replication
Atc_m105	COG4584	PFAM Integrase catalytic
Atc_m108	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Atc_m110	COG0640	Transcriptional regulator
Atc_m116	COG0741	lytic transglycosylase activity
Atc_m117	COG3409	Peptidoglycan-binding domain 1 protein
Atc_m117	COG5632	N-Acetylmuramoyl-L-alanine amidase
Atc_m126	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Atc_m137	COG0187	DNA topoisomerase II activity
Atc_m141	COG0629	single-stranded DNA binding
Atc_m158	COG4974	Belongs to the 'phage' integrase family
Atc_m162	COG1111	helicase
Atc_m162	COG1205	dead DEAH box helicase
Atc_m163	COG1484	DNA-dependent DNA replication
Atc_m165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Atc_m179	COG4372	Transposase
Atc_m183	COG3344	reverse transcriptase
Atc_m184	COG4372	Transposase
Atc_m187	COG0811	peptide transport
Atc_m196	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Atc_m200	COG1484	DNA-dependent DNA replication
Atc_m201	COG4584	PFAM Integrase catalytic
Atc_m203	COG3344	reverse transcriptase
Atc_m205	COG2433	Pfam Transposase IS66
Atc_m206	COG3436	PFAM IS66 Orf2 family protein
Atc_m214	COG0811	peptide transport
Atc_m217	COG1484	DNA-dependent DNA replication
Atc_m218	COG4584	PFAM Integrase catalytic
Atc_m229	COG0542	response to heat
Atc_m239	COG1192	Involved in chromosome partitioning
Atc_m240	COG1475	DNA binding
Atc_m242	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Atc_m251	COG4372	Transposase
Atc_m252	COG4372	Transposase