locus-tag	class	description
AFERRID_00020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFERRID_00030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFERRID_00120	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFERRID_00260	COG3451	type IV secretory pathway VirB4
AFERRID_00270	COG5268	conjugation
AFERRID_00280	COG3838	Conjugal transfer protein Trbc
AFERRID_00310	COG4962	Type ii secretion system protein e
AFERRID_00370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFERRID_00530	COG0531	amino acid
AFERRID_00540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AFERRID_00550	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AFERRID_00560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFERRID_00580	COG2326	polyphosphate kinase activity
AFERRID_00610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFERRID_00630	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AFERRID_00650	COG3387	PFAM Glycoside hydrolase 15-related
AFERRID_00680	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_00690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_00700	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_00700	COG0649	NAD binding
AFERRID_00720	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AFERRID_00740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFERRID_00750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_00770	COG0713	ATP synthesis coupled electron transport
AFERRID_00800	COG1007	ATP synthesis coupled electron transport
AFERRID_00810	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFERRID_00840	COG1028	Short-chain dehydrogenase reductase Sdr
AFERRID_00880	COG0583	DNA-binding transcription factor activity
AFERRID_00920	COG2814	Major facilitator Superfamily
AFERRID_01060	COG0076	glutamate decarboxylase activity
AFERRID_01070	COG0531	amino acid
AFERRID_01080	COG0531	amino acid
AFERRID_01110	COG2995	paraquat-inducible protein a
AFERRID_01160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AFERRID_01170	COG2217	Heavy metal translocating P-type atpase
AFERRID_01260	COG4974	Belongs to the 'phage' integrase family
AFERRID_01320	COG3561	AntA/AntB antirepressor
AFERRID_01520	COG2932	Transcriptional regulator
AFERRID_01560	COG4115	mRNA cleavage
AFERRID_01570	COG2161	toxin-antitoxin pair type II binding
AFERRID_01610	COG0187	DNA topoisomerase II activity
AFERRID_01620	COG0642	Histidine kinase
AFERRID_01630	COG0745	RESPONSE REGULATOR receiver
AFERRID_01840	COG4968	Prepilin-type N-terminal cleavage methylation domain
AFERRID_01990	COG1484	DNA-dependent DNA replication
AFERRID_02000	COG4584	PFAM Integrase catalytic
AFERRID_02010	COG3093	addiction module antidote protein HigA
AFERRID_02030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFERRID_02040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFERRID_02050	COG1862	Preprotein translocase
AFERRID_02060	COG0343	queuine tRNA-ribosyltransferase activity
AFERRID_02070	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AFERRID_02080	COG1253	flavin adenine dinucleotide binding
AFERRID_02110	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AFERRID_02130	COG0285	dihydrofolate synthase activity
AFERRID_02140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AFERRID_02150	COG0159	tryptophan synthase activity
AFERRID_02160	COG0133	tryptophan synthase activity
AFERRID_02170	COG0135	phosphoribosylanthranilate isomerase activity
AFERRID_02180	COG0101	tRNA pseudouridine synthase activity
AFERRID_02200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AFERRID_02220	COG0746	molybdenum cofactor guanylyltransferase activity
AFERRID_02230	COG1763	Mo-molybdopterin cofactor biosynthetic process
AFERRID_02240	COG0303	'Molybdopterin
AFERRID_02250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFERRID_02260	COG0616	signal peptide processing
AFERRID_02330	COG0501	Belongs to the peptidase M48B family
AFERRID_02410	COG2226	methyltransferase
AFERRID_02440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFERRID_02450	COG0154	amidase activity
AFERRID_02460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFERRID_02530	COG3394	polysaccharide catabolic process
AFERRID_02560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFERRID_02570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFERRID_02580	COG1657	PFAM Prenyltransferase squalene oxidase
AFERRID_02590	COG1562	ergosterol biosynthetic process
AFERRID_02600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFERRID_02610	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AFERRID_02620	COG0442	prolyl-tRNA aminoacylation
AFERRID_02660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AFERRID_02700	COG1692	metallophosphoesterase
AFERRID_02710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AFERRID_02740	COG0768	penicillin binding
AFERRID_02750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFERRID_02760	COG0193	aminoacyl-tRNA hydrolase activity
AFERRID_02770	COG0012	GTP binding
AFERRID_02780	COG1396	sequence-specific DNA binding
AFERRID_02830	COG0650	Formate hydrogenlyase subunit 4
AFERRID_02850	COG0651	ATP synthesis coupled electron transport
AFERRID_02860	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AFERRID_02860	COG3261	NADH dehydrogenase
AFERRID_02870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_02890	COG1850	ribulose-bisphosphate carboxylase activity
AFERRID_02930	COG2824	Alkylphosphonate utilization operon protein PhnA
AFERRID_02940	COG0726	polysaccharide deacetylase
AFERRID_02940	COG1649	PFAM Uncharacterised BCR, COG1649
AFERRID_02960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AFERRID_02970	COG0494	nUDIX hydrolase
AFERRID_02990	COG1187	pseudouridine synthase activity
AFERRID_03000	COG2957	Belongs to the agmatine deiminase family
AFERRID_03010	COG0243	molybdopterin cofactor binding
AFERRID_03070	COG0210	DNA helicase
AFERRID_03080	COG0268	Binds directly to 16S ribosomal RNA
AFERRID_03090	COG3842	ATPase activity
AFERRID_03120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFERRID_03130	COG0514	ATP-dependent DNA helicase (RecQ)
AFERRID_03140	COG1965	Belongs to the frataxin family
AFERRID_03180	COG0795	lipopolysaccharide-transporting ATPase activity
AFERRID_03190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFERRID_03220	COG0525	valine-tRNA ligase activity
AFERRID_03230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFERRID_03270	COG0412	Dienelactone hydrolase
AFERRID_03280	COG1902	pentaerythritol trinitrate reductase activity
AFERRID_03300	COG3152	Membrane
AFERRID_03340	COG0546	phosphoglycolate phosphatase activity
AFERRID_03360	COG1530	ribonuclease E activity
AFERRID_03370	COG0215	cysteine-tRNA ligase activity
AFERRID_03380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFERRID_03390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AFERRID_03430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFERRID_03440	COG0745	RESPONSE REGULATOR receiver
AFERRID_03450	COG2205	protein histidine kinase activity
AFERRID_03460	COG2205	protein histidine kinase activity
AFERRID_03490	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AFERRID_03500	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AFERRID_03520	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AFERRID_03530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFERRID_03550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFERRID_03570	COG0347	Belongs to the P(II) protein family
AFERRID_03700	COG0138	bifunctional purine biosynthesis protein purh
AFERRID_03710	COG0151	Belongs to the GarS family
AFERRID_03720	COG0009	L-threonylcarbamoyladenylate synthase
AFERRID_03730	COG0408	coproporphyrinogen oxidase activity
AFERRID_03740	COG0167	dihydroorotate dehydrogenase activity
AFERRID_03800	COG0811	peptide transport
AFERRID_03890	COG2814	Major facilitator Superfamily
AFERRID_03910	COG2062	phosphohistidine phosphatase, SixA
AFERRID_03930	COG2205	protein histidine kinase activity
AFERRID_03940	COG0745	RESPONSE REGULATOR receiver
AFERRID_03950	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AFERRID_03960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFERRID_03990	COG0033	Phosphoglucomutase
AFERRID_04010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFERRID_04020	COG3038	cytochrome b561
AFERRID_04040	COG2814	Major facilitator Superfamily
AFERRID_04050	COG0583	DNA-binding transcription factor activity
AFERRID_04080	COG1193	negative regulation of DNA recombination
AFERRID_04100	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AFERRID_04120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFERRID_04130	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFERRID_04160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFERRID_04210	COG1686	Belongs to the peptidase S11 family
AFERRID_04270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AFERRID_04280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFERRID_04300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFERRID_04310	COG1272	protein, Hemolysin III
AFERRID_04320	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFERRID_04340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AFERRID_04350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFERRID_04380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFERRID_04400	COG0640	Transcriptional regulator
AFERRID_04410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFERRID_04440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AFERRID_04450	COG0084	hydrolase, TatD family'
AFERRID_04460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFERRID_04470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFERRID_04530	COG2827	Endonuclease containing a URI domain
AFERRID_04590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AFERRID_04780	COG1199	ATP-dependent helicase activity
AFERRID_04810	COG0791	NLP P60 protein
AFERRID_04870	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AFERRID_04880	COG0586	Pfam SNARE associated Golgi protein
AFERRID_04940	COG0123	including yeast histone deacetylase and acetoin utilization protein
AFERRID_05040	COG0644	oxidoreductase
AFERRID_05050	COG0095	Lipoate-protein ligase
AFERRID_05070	COG0509	glycine decarboxylation via glycine cleavage system
AFERRID_05090	COG0509	glycine decarboxylation via glycine cleavage system
AFERRID_05100	COG2048	Heterodisulfide reductase, subunit B
AFERRID_05160	COG2210	Belongs to the sulfur carrier protein TusA family
AFERRID_05170	COG0425	Belongs to the sulfur carrier protein TusA family
AFERRID_05180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFERRID_05190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFERRID_05210	COG0315	cyclic pyranopterin monophosphate synthase activity
AFERRID_05220	COG1077	Cell shape determining protein MreB Mrl
AFERRID_05230	COG1077	Cell shape determining protein MreB Mrl
AFERRID_05240	COG1792	Involved in formation and maintenance of cell shape
AFERRID_05260	COG0768	penicillin binding
AFERRID_05270	COG0772	Belongs to the SEDS family
AFERRID_05280	COG1686	Belongs to the peptidase S11 family
AFERRID_05300	COG0321	lipoyl(octanoyl) transferase activity
AFERRID_05310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFERRID_05410	COG0751	glycine-tRNA ligase activity
AFERRID_05420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AFERRID_05440	COG0189	ligase activity
AFERRID_05480	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AFERRID_05540	COG0625	glutathione transferase activity
AFERRID_05550	COG1733	regulation of RNA biosynthetic process
AFERRID_05560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFERRID_05650	COG0776	regulation of translation
AFERRID_05660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFERRID_05660	COG0072	phenylalanine-tRNA ligase activity
AFERRID_05670	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFERRID_05680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFERRID_05690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFERRID_05700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AFERRID_05710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFERRID_05720	COG1007	ATP synthesis coupled electron transport
AFERRID_05750	COG0713	ATP synthesis coupled electron transport
AFERRID_05770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_05780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFERRID_05790	COG1034	ATP synthesis coupled electron transport
AFERRID_05800	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AFERRID_05810	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AFERRID_05820	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AFERRID_05830	COG0649	NAD binding
AFERRID_05840	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_05850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_05860	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFERRID_05870	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFERRID_05880	COG0149	triose-phosphate isomerase activity
AFERRID_05890	COG0149	triose-phosphate isomerase activity
AFERRID_05900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFERRID_05910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFERRID_05920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFERRID_05930	COG0312	modulator of DNA gyrase
AFERRID_05940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFERRID_05940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFERRID_05950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFERRID_06210	COG0717	Belongs to the dCTP deaminase family
AFERRID_06220	COG0489	protein tyrosine kinase activity
AFERRID_06240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AFERRID_06250	COG0484	heat shock protein binding
AFERRID_06260	COG0443	Heat shock 70 kDa protein
AFERRID_06270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFERRID_06280	COG1420	regulation of RNA biosynthetic process
AFERRID_06290	COG1420	regulation of RNA biosynthetic process
AFERRID_06300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFERRID_06310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFERRID_06320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFERRID_06320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFERRID_06330	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AFERRID_06340	COG0114	fumarate hydratase activity
AFERRID_06390	COG0297	glycogen (starch) synthase activity
AFERRID_06400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AFERRID_06420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFERRID_06480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFERRID_06600	COG4964	Belongs to the GSP D family
AFERRID_06710	COG0457	Tetratricopeptide repeat
AFERRID_06820	COG1028	Short-chain dehydrogenase reductase Sdr
AFERRID_06830	COG0723	plastoquinol--plastocyanin reductase activity
AFERRID_06840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFERRID_06850	COG2857	Cytochrome c1
AFERRID_06890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AFERRID_06900	COG1534	Rna-binding protein
AFERRID_06910	COG2967	ApaG domain
AFERRID_06920	COG2226	methyltransferase
AFERRID_06950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AFERRID_06980	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AFERRID_07000	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AFERRID_07030	COG2177	Part of the ABC transporter FtsEX involved in
AFERRID_07040	COG2884	Cell division ATP-binding protein ftsE
AFERRID_07050	COG0552	protein localization to endoplasmic reticulum
AFERRID_07060	COG0742	ribosomal rna small subunit methyltransferase
AFERRID_07070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFERRID_07080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFERRID_07090	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AFERRID_07100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFERRID_07110	COG2890	protein-(glutamine-N5) methyltransferase activity
AFERRID_07120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AFERRID_07140	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AFERRID_07150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFERRID_07160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AFERRID_07180	COG3077	Addiction module antitoxin, RelB DinJ family
AFERRID_07190	COG2860	membrane
AFERRID_07290	COG2943	transferase activity, transferring hexosyl groups
AFERRID_07300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFERRID_07430	COG0746	molybdenum cofactor guanylyltransferase activity
AFERRID_07490	COG1872	DUF167
AFERRID_07540	COG0148	phosphopyruvate hydratase activity
AFERRID_07570	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFERRID_07610	COG3459	Glycosyltransferase 36 associated
AFERRID_07680	COG0006	proline dipeptidase activity
AFERRID_07710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFERRID_07720	COG0305	Participates in initiation and elongation during chromosome replication
AFERRID_07730	COG0359	binds to the 23S rRNA
AFERRID_07760	COG0360	Binds together with S18 to 16S ribosomal RNA
AFERRID_07770	COG1472	Belongs to the glycosyl hydrolase 3 family
AFERRID_07780	COG0531	amino acid
AFERRID_07800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFERRID_07850	COG0363	glucosamine-6-phosphate deaminase activity
AFERRID_07880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AFERRID_07890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AFERRID_07910	COG1449	Belongs to the glycosyl hydrolase 57 family
AFERRID_07920	COG1940	carbohydrate kinase activity
AFERRID_07930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFERRID_07940	COG2733	membrane
AFERRID_07960	COG0629	single-stranded DNA binding
AFERRID_07990	COG3118	belongs to the thioredoxin family
AFERRID_08000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFERRID_08030	COG0335	large ribosomal subunit rRNA binding
AFERRID_08040	COG0336	Belongs to the RNA methyltransferase TrmD family
AFERRID_08050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AFERRID_08060	COG0228	four-way junction DNA binding
AFERRID_08070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AFERRID_08080	COG0431	NADPH-dependent FMN reductase
AFERRID_08110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFERRID_08130	COG1131	(ABC) transporter
AFERRID_08140	COG0842	Transport permease protein
AFERRID_08150	COG0842	Transport permease protein
AFERRID_08160	COG0842	Transport permease protein
AFERRID_08210	COG0509	glycine decarboxylation via glycine cleavage system
AFERRID_08270	COG2885	chlorophyll binding
AFERRID_08420	COG1573	uracil-dna glycosylase
AFERRID_08490	COG0142	geranyltranstransferase activity
AFERRID_08520	COG3852	Histidine kinase
AFERRID_08540	COG2308	Evidence 4 Homologs of previously reported genes of
AFERRID_08570	COG2766	serine protein kinase
AFERRID_08580	COG0004	ammonium transporteR
AFERRID_08590	COG2718	Belongs to the UPF0229 family
AFERRID_08600	COG2719	SpoVR family
AFERRID_08630	COG0347	Belongs to the P(II) protein family
AFERRID_08640	COG0004	ammonium transporteR
AFERRID_08700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFERRID_08710	COG1686	Belongs to the peptidase S11 family
AFERRID_08720	COG0166	Belongs to the GPI family
AFERRID_08750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFERRID_08780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFERRID_08800	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AFERRID_08820	COG1074	ATP-dependent DNA helicase activity
AFERRID_08830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFERRID_08840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFERRID_08850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFERRID_08940	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFERRID_08950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFERRID_08960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFERRID_08980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFERRID_09000	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AFERRID_09030	COG0424	maF-like protein
AFERRID_09040	COG1530	ribonuclease E activity
AFERRID_09050	COG2204	response regulator
AFERRID_09070	COG2205	protein histidine kinase activity
AFERRID_09090	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AFERRID_09110	COG1596	polysaccharide export
AFERRID_09210	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AFERRID_09350	COG1132	(ABC) transporter
AFERRID_09360	COG2153	protein acetylation
AFERRID_09410	COG0444	Belongs to the ABC transporter superfamily
AFERRID_09420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFERRID_09430	COG0601	transmembrane transport
AFERRID_09480	COG2095	MarC family integral membrane protein
AFERRID_09490	COG0039	L-malate dehydrogenase activity
AFERRID_09520	COG0811	peptide transport
AFERRID_09530	COG0848	biopolymer transport protein
AFERRID_09560	COG1028	Short-chain dehydrogenase reductase Sdr
AFERRID_09560	COG3321	synthase
AFERRID_09560	COG0604	alcohol dehydrogenase
AFERRID_09570	COG0156	8-amino-7-oxononanoate synthase activity
AFERRID_09620	COG1194	a g-specific adenine glycosylase
AFERRID_09640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFERRID_09650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFERRID_09670	COG1660	Displays ATPase and GTPase activities
AFERRID_09680	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AFERRID_09690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFERRID_09690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFERRID_09690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFERRID_09730	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AFERRID_09750	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AFERRID_09800	COG3178	'Phosphotransferase
AFERRID_09810	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AFERRID_09820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFERRID_09830	COG0842	Transport permease protein
AFERRID_09840	COG0842	Transport permease protein
AFERRID_09860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AFERRID_09870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFERRID_09880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFERRID_09900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFERRID_09910	COG0131	Imidazoleglycerol-phosphate dehydratase
AFERRID_09920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFERRID_09930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFERRID_09940	COG0107	imidazoleglycerol-phosphate synthase activity
AFERRID_09950	COG0140	phosphoribosyl-ATP diphosphatase activity
AFERRID_09950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFERRID_09960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFERRID_09970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFERRID_09980	COG0805	protein transport
AFERRID_09990	COG1850	ribulose-bisphosphate carboxylase activity
AFERRID_10030	COG0776	regulation of translation
AFERRID_10060	COG0540	Belongs to the ATCase OTCase family
AFERRID_10070	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AFERRID_10080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AFERRID_10100	COG1678	Uncharacterized ACR, COG1678
AFERRID_10110	COG0189	ligase activity
AFERRID_10140	COG0316	Belongs to the HesB IscA family
AFERRID_10150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFERRID_10160	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFERRID_10160	COG0022	dehydrogenase e1 component
AFERRID_10170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AFERRID_10200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFERRID_10210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFERRID_10220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFERRID_10240	COG0778	Nitroreductase
AFERRID_10250	COG1376	ErfK ybiS ycfS ynhG family protein
AFERRID_10270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFERRID_10280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AFERRID_10300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AFERRID_10320	COG0492	ferredoxin-NADP+ reductase activity
AFERRID_10340	COG0789	Transcriptional regulator
AFERRID_10350	COG0585	pseudouridine synthase activity
AFERRID_10360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFERRID_10370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFERRID_10380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AFERRID_10390	COG0560	Phosphoserine phosphatase
AFERRID_10400	COG0678	peroxiredoxin activity
AFERRID_10400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AFERRID_10470	COG0671	phosphoesterase, PA-phosphatase related
AFERRID_10490	COG2003	Belongs to the UPF0758 family
AFERRID_10500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AFERRID_10510	COG0756	dUTP diphosphatase activity
AFERRID_10520	COG0203	ribosomal protein L17
AFERRID_10530	COG0202	RNA polymerase activity
AFERRID_10540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFERRID_10550	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFERRID_10560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFERRID_10570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFERRID_10580	COG0563	adenylate kinase activity
AFERRID_10590	COG0201	protein transport
AFERRID_10600	COG0200	Binds to the 23S rRNA
AFERRID_10610	COG1841	ribosomal large subunit assembly
AFERRID_10620	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFERRID_10630	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFERRID_10640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFERRID_10650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFERRID_10660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFERRID_10670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFERRID_10680	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFERRID_10690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFERRID_10700	COG0255	Belongs to the universal ribosomal protein uL29 family
AFERRID_10710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFERRID_10730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFERRID_10740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFERRID_10750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFERRID_10760	COG0089	rRNA binding
AFERRID_10770	COG0088	Forms part of the polypeptide exit tunnel
AFERRID_10780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFERRID_10790	COG0051	transcription antitermination factor activity, RNA binding
AFERRID_10800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFERRID_10810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFERRID_10820	COG0049	tRNA binding
AFERRID_10830	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFERRID_10840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFERRID_10850	COG0085	RNA polymerase activity
AFERRID_10860	COG0222	ribosome binding
AFERRID_10870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AFERRID_10880	COG0081	regulation of translation
AFERRID_10890	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AFERRID_10920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFERRID_10940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AFERRID_10980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFERRID_10990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFERRID_11020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFERRID_11020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFERRID_11030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFERRID_11040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFERRID_11060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFERRID_11070	COG2813	Specifically methylates the guanine in position
AFERRID_11070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFERRID_11090	COG2226	methyltransferase
AFERRID_11100	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AFERRID_11110	COG0288	reversible hydration of carbon dioxide
AFERRID_11120	COG0659	secondary active sulfate transmembrane transporter activity
AFERRID_11180	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AFERRID_11190	COG1671	Belongs to the UPF0178 family
AFERRID_11200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFERRID_11210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFERRID_11220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFERRID_11230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFERRID_11240	COG0735	belongs to the Fur family
AFERRID_11280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFERRID_11320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AFERRID_11330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFERRID_11340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFERRID_11350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFERRID_11480	COG1872	DUF167
AFERRID_11490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFERRID_11510	COG1566	PFAM secretion protein HlyD family protein
AFERRID_11520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFERRID_11530	COG1309	transcriptional regulator
AFERRID_11580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFERRID_11580	COG0543	2 iron, 2 sulfur cluster binding
AFERRID_11600	COG0390	transport system, permease component
AFERRID_11610	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AFERRID_11620	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AFERRID_11640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFERRID_11670	COG1040	competence protein
AFERRID_11680	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AFERRID_11690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFERRID_11700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AFERRID_11710	COG1560	Kdo2-lipid A biosynthetic process
AFERRID_11720	COG1519	Transferase
AFERRID_11740	COG0859	PFAM glycosyl transferase family 9
AFERRID_11750	COG0463	Glycosyl transferase, family 2
AFERRID_11800	COG0297	glycogen (starch) synthase activity
AFERRID_11820	COG0463	Glycosyl transferase, family 2
AFERRID_11830	COG0494	nUDIX hydrolase
AFERRID_11840	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFERRID_11850	COG0653	protein targeting
AFERRID_11870	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AFERRID_11880	COG0625	glutathione transferase activity
AFERRID_11890	COG1022	Amp-dependent synthetase and ligase
AFERRID_11920	COG2001	Belongs to the MraZ family
AFERRID_11930	COG0275	rRNA processing
AFERRID_11960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFERRID_11970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AFERRID_11980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFERRID_11990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFERRID_12000	COG0772	Belongs to the SEDS family
AFERRID_12010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFERRID_12020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFERRID_12030	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AFERRID_12040	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFERRID_12050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AFERRID_12080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFERRID_12110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFERRID_12120	COG0511	ligase activity, forming carbon-carbon bonds
AFERRID_12130	COG0439	Biotin carboxylase
AFERRID_12140	COG2264	protein methyltransferase activity
AFERRID_12160	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AFERRID_12170	COG0739	heme binding
AFERRID_12170	COG0741	lytic transglycosylase activity
AFERRID_12170	COG1196	nuclear chromosome segregation
AFERRID_12190	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AFERRID_12210	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AFERRID_12220	COG0237	dephospho-CoA kinase activity
AFERRID_12270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AFERRID_12280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFERRID_12290	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AFERRID_12300	COG1047	Peptidyl-prolyl cis-trans
AFERRID_12310	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AFERRID_12320	COG0708	Exodeoxyribonuclease III
AFERRID_12330	COG0625	glutathione transferase activity
AFERRID_12340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AFERRID_12360	COG0708	Exodeoxyribonuclease III
AFERRID_12380	COG0583	DNA-binding transcription factor activity
AFERRID_12400	COG0018	arginyl-trna synthetase
AFERRID_12430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFERRID_12450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AFERRID_12460	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AFERRID_12470	COG1131	(ABC) transporter
AFERRID_12500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AFERRID_12510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AFERRID_12520	COG1127	ABC transporter
AFERRID_12530	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AFERRID_12540	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFERRID_12560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFERRID_12580	COG2363	Small membrane protein
AFERRID_12630	COG1902	pentaerythritol trinitrate reductase activity
AFERRID_12640	COG3077	Addiction module antitoxin, RelB DinJ family
AFERRID_12680	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFERRID_12760	COG0535	radical SAM domain protein
AFERRID_12780	COG0582	viral genome integration into host DNA
AFERRID_12800	COG3107	peptidoglycan biosynthetic process
AFERRID_12810	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AFERRID_12820	COG0277	FAD linked oxidase domain protein
AFERRID_12840	COG0859	PFAM glycosyl transferase family 9
AFERRID_12860	COG0583	DNA-binding transcription factor activity
AFERRID_12960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFERRID_12970	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AFERRID_12980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AFERRID_13000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFERRID_13010	COG2833	Protein of unknown function (DUF455)
AFERRID_13060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFERRID_13070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFERRID_13090	COG0745	RESPONSE REGULATOR receiver
AFERRID_13100	COG2205	protein histidine kinase activity
AFERRID_13140	COG1136	(ABC) transporter
AFERRID_13250	COG4453	Protein conserved in bacteria
AFERRID_13300	COG0789	Transcriptional regulator
AFERRID_13450	COG4115	mRNA cleavage
AFERRID_13460	COG2161	toxin-antitoxin pair type II binding
AFERRID_13470	COG4691	Plasmid stability protein
AFERRID_13500	COG2885	chlorophyll binding
AFERRID_13520	COG0602	queuosine metabolic process
AFERRID_13530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AFERRID_13540	COG0823	Involved in the tonB-independent uptake of proteins
AFERRID_13590	COG0824	Thioesterase
AFERRID_13600	COG2255	four-way junction helicase activity
AFERRID_13610	COG0632	four-way junction helicase activity
AFERRID_13620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AFERRID_13630	COG0217	transcriptional regulatory protein
AFERRID_13650	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AFERRID_13660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFERRID_13680	COG2095	MarC family integral membrane protein
AFERRID_13840	COG1566	PFAM secretion protein HlyD family protein
AFERRID_13860	COG0488	(ABC) transporter
AFERRID_13870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AFERRID_13890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AFERRID_13900	COG0706	membrane insertase activity
AFERRID_13910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AFERRID_13930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFERRID_13940	COG2204	response regulator
AFERRID_13950	COG3852	Histidine kinase
AFERRID_13970	COG1028	Short-chain dehydrogenase reductase Sdr
AFERRID_13980	COG0723	plastoquinol--plastocyanin reductase activity
AFERRID_13990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFERRID_14010	COG1333	cytochrome c biogenesis protein
AFERRID_14020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFERRID_14110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AFERRID_14120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFERRID_14130	COG0175	sulfate reduction
AFERRID_14150	COG2895	sulfate adenylyltransferase (ATP) activity
AFERRID_14200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFERRID_14270	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AFERRID_14310	COG2814	Major facilitator Superfamily
AFERRID_14320	COG0109	protoheme IX farnesyltransferase activity
AFERRID_14380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFERRID_14390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFERRID_14440	COG2204	response regulator
AFERRID_14450	COG5000	phosphorelay sensor kinase activity
AFERRID_14470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AFERRID_14480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFERRID_14490	COG0242	peptide deformylase activity
AFERRID_14510	COG0758	DNA mediated transformation
AFERRID_14520	COG2922	Belongs to the Smg family
AFERRID_14540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFERRID_14550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AFERRID_14560	COG0850	regulation of cytokinetic process
AFERRID_14570	COG2894	cell division
AFERRID_14580	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AFERRID_14600	COG3267	Type II secretory pathway component ExeA
AFERRID_14600	COG3409	Peptidoglycan-binding domain 1 protein
AFERRID_14750	COG0493	'glutamate synthase
AFERRID_14750	COG0543	2 iron, 2 sulfur cluster binding
AFERRID_14770	COG0187	DNA topoisomerase II activity
AFERRID_14790	COG0592	DNA-directed DNA polymerase activity
AFERRID_14800	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFERRID_14810	COG0300	oxidoreductase activity
AFERRID_14820	COG0351	phosphomethylpyrimidine kinase
AFERRID_14830	COG0352	thiamine-phosphate diphosphorylase activity
AFERRID_14840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFERRID_14850	COG0537	adenosine 5'-monophosphoramidase activity
AFERRID_14870	COG0181	hydroxymethylbilane synthase activity
AFERRID_14890	COG0113	porphobilinogen synthase activity
AFERRID_14940	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AFERRID_14940	COG0662	Cupin 2, conserved barrel domain protein
AFERRID_14970	COG0409	Hydrogenase expression formation protein
AFERRID_15000	COG0375	protein maturation
AFERRID_15010	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AFERRID_15020	COG2181	nitrate reductase activity
AFERRID_15020	COG0247	lactate metabolic process
AFERRID_15100	COG0165	Argininosuccinate lyase
AFERRID_15120	COG2205	protein histidine kinase activity
AFERRID_15130	COG0745	RESPONSE REGULATOR receiver
AFERRID_15270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFERRID_15310	COG1970	mechanosensitive ion channel activity
AFERRID_15320	COG1322	Protein conserved in bacteria
AFERRID_15330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFERRID_15340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AFERRID_15360	COG0483	inositol monophosphate 1-phosphatase activity
AFERRID_15370	COG1494	fructose-1,6-bisphosphatase
AFERRID_15380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AFERRID_15390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFERRID_15400	COG0126	phosphoglycerate kinase activity
AFERRID_15430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AFERRID_15440	COG0546	phosphoglycolate phosphatase activity
AFERRID_15470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFERRID_15480	COG0134	indole-3-glycerol-phosphate synthase activity
AFERRID_15500	COG1959	2 iron, 2 sulfur cluster binding
AFERRID_15510	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AFERRID_15540	COG1131	(ABC) transporter
AFERRID_15560	COG0393	Putative heavy-metal-binding
AFERRID_15600	COG0625	glutathione transferase activity
AFERRID_15660	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AFERRID_15680	COG0732	type I restriction modification DNA specificity domain
AFERRID_15740	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFERRID_15830	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFERRID_15890	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFERRID_15920	COG0445	tRNA wobble uridine modification
AFERRID_15930	COG0357	Ribosomal RNA small subunit methyltransferase G
AFERRID_15940	COG1192	Involved in chromosome partitioning
AFERRID_15950	COG1475	DNA binding
AFERRID_15970	COG0356	it plays a direct role in the translocation of protons across the membrane
AFERRID_15990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFERRID_16000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFERRID_16010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFERRID_16020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AFERRID_16050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFERRID_16070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFERRID_16080	COG0326	Molecular chaperone. Has ATPase activity
AFERRID_16090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AFERRID_16090	COG1796	DNA polymerase
AFERRID_16130	COG0210	DNA helicase
AFERRID_16140	COG1555	photosystem II stabilization
AFERRID_16170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AFERRID_16190	COG1611	Belongs to the LOG family
AFERRID_16210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFERRID_16220	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AFERRID_16240	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AFERRID_16250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFERRID_16270	COG0779	Required for maturation of 30S ribosomal subunits
AFERRID_16280	COG0195	Participates in both transcription termination and antitermination
AFERRID_16290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFERRID_16300	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFERRID_16310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AFERRID_16320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFERRID_16330	COG1185	polyribonucleotide nucleotidyltransferase activity
AFERRID_16340	COG0612	Peptidase, M16
AFERRID_16350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFERRID_16370	COG0328	RNA-DNA hybrid ribonuclease activity
AFERRID_16380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AFERRID_16410	COG0137	argininosuccinate synthase activity
AFERRID_16420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFERRID_16430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFERRID_16440	COG0527	aspartate kinase activity
AFERRID_16500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFERRID_16520	COG1388	LysM domain
AFERRID_16520	COG0741	lytic transglycosylase activity
AFERRID_16530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFERRID_16590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFERRID_16600	COG0538	isocitrate dehydrogenase activity
AFERRID_16610	COG0045	succinate-CoA ligase (ADP-forming) activity
AFERRID_16630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AFERRID_16640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFERRID_16640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFERRID_16700	COG1850	ribulose-bisphosphate carboxylase activity
AFERRID_16710	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AFERRID_16720	COG0235	Class ii aldolase
AFERRID_16740	COG0242	peptide deformylase activity
AFERRID_16760	COG0531	amino acid
AFERRID_16810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFERRID_16830	COG2204	response regulator
AFERRID_16850	COG2205	protein histidine kinase activity
AFERRID_16860	COG0497	DNA recombination
AFERRID_16870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFERRID_16880	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AFERRID_16890	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AFERRID_16890	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AFERRID_16900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFERRID_16920	COG1466	dna polymerase III delta subunit
AFERRID_16940	COG0495	leucyl-tRNA aminoacylation
AFERRID_16950	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFERRID_16960	COG2353	YceI-like domain
AFERRID_16970	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AFERRID_16980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFERRID_17000	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AFERRID_17030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AFERRID_17040	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AFERRID_17050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AFERRID_17080	COG0436	Aminotransferase
AFERRID_17100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFERRID_17120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AFERRID_17130	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFERRID_17140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFERRID_17160	COG1136	(ABC) transporter
AFERRID_17180	COG0658	competence protein
AFERRID_17180	COG2333	competence protein COMEC
AFERRID_17190	COG0811	peptide transport
AFERRID_17200	COG0848	biopolymer transport protein
AFERRID_17230	COG1663	tetraacyldisaccharide 4'-kinase activity
AFERRID_17240	COG2835	tetraacyldisaccharide 4'-kinase activity
AFERRID_17250	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AFERRID_17290	COG0653	protein targeting
AFERRID_17330	COG1942	4-Oxalocrotonate Tautomerase
AFERRID_17350	COG4372	Transposase
AFERRID_17470	COG1573	uracil-dna glycosylase
AFERRID_17480	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AFERRID_17490	COG0542	response to heat
AFERRID_17500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AFERRID_17510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFERRID_17520	COG0693	protein deglycase activity
AFERRID_17530	COG0793	Belongs to the peptidase S41A family
AFERRID_17550	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AFERRID_17560	COG0058	SHG alpha-glucan phosphorylase activity
AFERRID_17580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFERRID_17610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFERRID_17620	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AFERRID_17670	COG0529	Catalyzes the synthesis of activated sulfate
AFERRID_17670	COG2046	Belongs to the sulfate adenylyltransferase family
AFERRID_17690	COG0459	protein refolding
AFERRID_17700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AFERRID_17730	COG4232	protein-disulfide reductase activity
AFERRID_17760	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AFERRID_17780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFERRID_17820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFERRID_17830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFERRID_17840	COG0196	riboflavin kinase activity
AFERRID_17870	COG1561	YicC-like family, N-terminal region
AFERRID_17880	COG0194	GDP metabolic process
AFERRID_17890	COG1758	RNA polymerase activity
AFERRID_17900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFERRID_17960	COG0628	permease
AFERRID_17980	COG1355	regulation of microtubule-based process
AFERRID_17990	COG2078	PFAM AMMECR1 domain protein
AFERRID_18010	COG1538	Outer membrane efflux protein
AFERRID_18050	COG5377	YqaJ viral recombinase family
AFERRID_18120	COG4372	Transposase
AFERRID_18210	COG0513	Belongs to the DEAD box helicase family
AFERRID_18220	COG1278	Cold shock
AFERRID_18230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AFERRID_18260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFERRID_18280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFERRID_18290	COG1702	phosphate starvation-inducible protein PhoH
AFERRID_18300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFERRID_18310	COG4535	Mg2 and Co2 transporter CorC
AFERRID_18320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AFERRID_18330	COG0312	modulator of DNA gyrase
AFERRID_18350	COG1121	(ABC) transporter
AFERRID_18370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFERRID_18470	COG0438	transferase activity, transferring glycosyl groups
AFERRID_18480	COG0438	transferase activity, transferring glycosyl groups
AFERRID_18490	COG1132	(ABC) transporter
AFERRID_18500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFERRID_18510	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFERRID_18530	COG0406	alpha-ribazole phosphatase activity
AFERRID_18530	COG0328	RNA-DNA hybrid ribonuclease activity
AFERRID_18560	COG2226	methyltransferase
AFERRID_18570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFERRID_18580	COG0066	3-isopropylmalate dehydratase activity
AFERRID_18600	COG0259	pyridoxamine-phosphate oxidase activity
AFERRID_18610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AFERRID_18640	COG1271	oxidase subunit
AFERRID_18710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFERRID_18720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFERRID_18750	COG0109	protoheme IX farnesyltransferase activity
AFERRID_18760	COG2814	Major facilitator Superfamily
AFERRID_18770	COG1968	undecaprenyl-diphosphatase activity
AFERRID_18780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFERRID_18800	COG0505	Belongs to the CarA family
AFERRID_18830	COG2022	thiamine diphosphate biosynthetic process
AFERRID_18850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFERRID_18860	COG0163	prenyltransferase activity
AFERRID_18870	COG1127	ABC transporter
AFERRID_18880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AFERRID_18920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFERRID_18950	COG1136	(ABC) transporter
AFERRID_18980	COG0254	rRNA binding
AFERRID_18990	COG0281	malic enzyme
AFERRID_19000	COG0628	permease
AFERRID_19010	COG0129	dihydroxy-acid dehydratase activity
AFERRID_19040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AFERRID_19040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFERRID_19050	COG0271	Belongs to the BolA IbaG family
AFERRID_19060	COG2350	Protein conserved in bacteria
AFERRID_19070	COG2917	probably involved in intracellular septation
AFERRID_19100	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AFERRID_19120	COG1959	2 iron, 2 sulfur cluster binding
AFERRID_19130	COG1104	cysteine desulfurase activity
AFERRID_19140	COG0822	iron-sulfur transferase activity
AFERRID_19170	COG0443	Heat shock 70 kDa protein
AFERRID_19200	COG0482	sulfurtransferase activity
AFERRID_19210	COG1752	Esterase of the alpha-beta hydrolase superfamily
AFERRID_19260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFERRID_19290	COG3284	Transcriptional regulator
AFERRID_19300	COG3791	Glutathione-dependent formaldehyde-activating
AFERRID_19310	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AFERRID_19320	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AFERRID_19330	COG0583	DNA-binding transcription factor activity
AFERRID_19340	COG2204	response regulator
AFERRID_19440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AFERRID_19480	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AFERRID_19570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFERRID_19630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFERRID_19640	COG0493	'glutamate synthase
AFERRID_19650	COG0067	glutamate synthase
AFERRID_19650	COG0070	glutamate synthase
AFERRID_19650	COG0069	glutamate synthase activity
AFERRID_19660	COG0069	glutamate synthase activity
AFERRID_19660	COG0067	glutamate synthase
AFERRID_19660	COG0070	glutamate synthase
AFERRID_19670	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AFERRID_19680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AFERRID_19690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFERRID_19750	COG0590	tRNA wobble adenosine to inosine editing
AFERRID_19760	COG0432	Pfam Uncharacterised protein family UPF0047
AFERRID_19780	COG1193	negative regulation of DNA recombination
AFERRID_19790	COG0028	Belongs to the TPP enzyme family
AFERRID_19810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFERRID_19820	COG0688	phosphatidylethanolamine metabolic process
AFERRID_19830	COG1183	phosphatidylcholine synthase activity
AFERRID_19850	COG0589	response to stress
AFERRID_19860	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AFERRID_19870	COG1196	nuclear chromosome segregation
AFERRID_19900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFERRID_19980	COG0730	response to heat
AFERRID_19990	COG0811	peptide transport
AFERRID_20040	COG0402	S-adenosylhomocysteine deaminase activity
AFERRID_20050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AFERRID_20120	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AFERRID_20120	COG3608	succinylglutamate desuccinylase aspartoacylase
AFERRID_20160	COG0746	molybdenum cofactor guanylyltransferase activity
AFERRID_20300	COG0475	glutathione-regulated potassium exporter activity
AFERRID_20310	COG1028	Short-chain dehydrogenase reductase Sdr
AFERRID_20460	COG2814	Major facilitator Superfamily
AFERRID_20470	COG0038	chloride channel
AFERRID_20490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AFERRID_20500	COG2217	Heavy metal translocating P-type atpase
AFERRID_20500	COG2217	Heavy metal translocating P-type atpase
AFERRID_20540	COG4654	Cytochrome c, class I
AFERRID_20580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFERRID_20600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AFERRID_20620	COG0583	DNA-binding transcription factor activity
AFERRID_20670	COG2217	Heavy metal translocating P-type atpase
AFERRID_20720	COG0477	Major facilitator Superfamily
AFERRID_20740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFERRID_20740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFERRID_20780	COG2154	pterin-4-alpha-carbinolamine dehydratase
AFERRID_20800	COG0556	nucleotide-excision repair
AFERRID_20810	COG1064	alcohol dehydrogenase
AFERRID_20820	COG0504	CTP synthase activity
AFERRID_20830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AFERRID_20840	COG0148	phosphopyruvate hydratase activity
AFERRID_20850	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AFERRID_20860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFERRID_20880	COG0322	excinuclease ABC activity
AFERRID_20920	COG1648	precorrin-2 dehydrogenase activity
AFERRID_20920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFERRID_20930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFERRID_20940	COG0243	molybdopterin cofactor binding
AFERRID_20950	COG2146	nitrite reductase [NAD(P)H] activity
AFERRID_20960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFERRID_20980	COG2223	nitrite transmembrane transporter activity
AFERRID_20990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFERRID_20990	COG1116	anion transmembrane transporter activity
AFERRID_21010	COG3189	MarR family transcriptional regulator
AFERRID_21040	COG1017	nitric oxide dioxygenase activity
AFERRID_21040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFERRID_21050	COG1566	PFAM secretion protein HlyD family protein
AFERRID_21060	COG1538	Outer membrane efflux protein
AFERRID_21070	COG2814	Major facilitator Superfamily
AFERRID_21080	COG0583	DNA-binding transcription factor activity
AFERRID_21140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AFERRID_21150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AFERRID_21160	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AFERRID_21180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFERRID_21200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFERRID_21210	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AFERRID_21220	COG0287	Prephenate dehydrogenase
AFERRID_21230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFERRID_21240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AFERRID_21260	COG0776	regulation of translation
AFERRID_21270	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AFERRID_21280	COG0284	orotidine-5'-phosphate decarboxylase activity
AFERRID_21290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFERRID_21300	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFERRID_21310	COG0740	serine-type endopeptidase activity
AFERRID_21320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AFERRID_21330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AFERRID_21350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFERRID_21410	COG2915	High frequency lysogenization protein hflD homolog
AFERRID_21420	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AFERRID_21430	COG0024	Methionine aminopeptidase
AFERRID_21440	COG1489	DNA binding
AFERRID_21450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFERRID_21470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AFERRID_21480	COG1546	Belongs to the CinA family
AFERRID_21480	COG1058	Belongs to the CinA family
AFERRID_21490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AFERRID_21500	COG2137	regulation of response to DNA damage stimulus
AFERRID_21580	COG0739	heme binding
AFERRID_21580	COG0741	lytic transglycosylase activity
AFERRID_21580	COG1196	nuclear chromosome segregation
AFERRID_21590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFERRID_21630	COG0488	(ABC) transporter
AFERRID_21640	COG0488	(ABC) transporter
AFERRID_21650	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AFERRID_21710	COG1294	oxidase, subunit
AFERRID_21720	COG1271	oxidase subunit
AFERRID_21750	COG0400	carboxylic ester hydrolase activity
AFERRID_21760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFERRID_21770	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AFERRID_21790	COG2943	transferase activity, transferring hexosyl groups
AFERRID_21790	COG3416	Protein conserved in bacteria
AFERRID_21810	COG2363	Small membrane protein
AFERRID_21830	COG0616	signal peptide processing
AFERRID_21840	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AFERRID_21850	COG0314	molybdopterin synthase activity
AFERRID_21860	COG1666	GTP binding
AFERRID_21880	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AFERRID_21890	COG0509	glycine decarboxylation via glycine cleavage system
AFERRID_21900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFERRID_21910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFERRID_21920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFERRID_21930	COG1132	(ABC) transporter
AFERRID_21940	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AFERRID_21950	COG0450	alkyl hydroperoxide reductase
AFERRID_21970	COG0613	PHP domain protein
AFERRID_21980	COG0628	permease
AFERRID_22020	COG0084	hydrolase, TatD family'
AFERRID_22030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AFERRID_22030	COG0321	lipoyl(octanoyl) transferase activity
AFERRID_22060	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AFERRID_22080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFERRID_22110	COG2353	YceI-like domain
AFERRID_22130	COG1846	Transcriptional regulator
AFERRID_22160	COG4988	ABC transporter
AFERRID_22180	COG0354	folic acid binding
AFERRID_22200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFERRID_22230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFERRID_22240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFERRID_22250	COG0481	GTPase activity
AFERRID_22260	COG0681	Belongs to the peptidase S26 family
AFERRID_22280	COG0571	ribonuclease III activity
AFERRID_22290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFERRID_22300	COG1381	Involved in DNA repair and RecF pathway recombination
AFERRID_22310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AFERRID_22320	COG0736	holo-[acyl-carrier-protein] synthase activity
AFERRID_22340	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AFERRID_22340	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AFERRID_22350	COG0037	tRNA processing
AFERRID_22360	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AFERRID_22390	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AFERRID_22410	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFERRID_22570	COG0513	Belongs to the DEAD box helicase family
AFERRID_22600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AFERRID_22610	COG0573	inorganic phosphate transmembrane transporter activity
AFERRID_22620	COG0581	inorganic phosphate transmembrane transporter activity
AFERRID_22630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFERRID_22640	COG0704	Plays a role in the regulation of phosphate uptake
AFERRID_22670	COG0052	Belongs to the universal ribosomal protein uS2 family
AFERRID_22680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFERRID_22690	COG0528	UMP kinase activity
AFERRID_22710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFERRID_22720	COG0575	Belongs to the CDS family
AFERRID_22730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AFERRID_22770	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFERRID_22780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AFERRID_22790	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFERRID_22800	COG0673	inositol 2-dehydrogenase activity
AFERRID_22820	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFERRID_22850	COG0825	malonyl-CoA metabolic process
AFERRID_22860	COG0037	tRNA processing
AFERRID_22880	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AFERRID_22890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFERRID_22910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFERRID_22920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AFERRID_22930	COG1166	arginine decarboxylase activity
AFERRID_23000	COG3411	Ferredoxin
AFERRID_23030	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFERRID_23080	COG0811	peptide transport
AFERRID_23110	COG1120	ATPase activity
AFERRID_23130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFERRID_23330	COG5420	small protein containing a coiled-coil domain
AFERRID_23360	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AFERRID_23370	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AFERRID_23480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFERRID_23490	COG0316	Belongs to the HesB IscA family
AFERRID_23530	COG5554	nitrogen fixation
AFERRID_23560	COG5554	nitrogen fixation
AFERRID_23590	COG0633	Ferredoxin
AFERRID_23640	COG1012	belongs to the aldehyde dehydrogenase family
AFERRID_23680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFERRID_23690	COG0438	transferase activity, transferring glycosyl groups
AFERRID_23700	COG0438	transferase activity, transferring glycosyl groups
AFERRID_23710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFERRID_23730	COG4974	Belongs to the 'phage' integrase family
AFERRID_23790	COG1484	DNA-dependent DNA replication
AFERRID_23820	COG0629	single-stranded DNA binding
AFERRID_23950	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFERRID_24010	COG0776	regulation of translation
AFERRID_24050	COG3077	Addiction module antitoxin, RelB DinJ family
AFERRID_24200	COG3657	addiction module killer protein
AFERRID_24210	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFERRID_24240	COG4962	Type ii secretion system protein e
AFERRID_24270	COG3451	type IV secretory pathway VirB4
AFERRID_24340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFERRID_24390	COG2084	Dehydrogenase
AFERRID_24400	COG0243	molybdopterin cofactor binding
AFERRID_24420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFERRID_24440	COG0543	2 iron, 2 sulfur cluster binding
AFERRID_24440	COG0633	Ferredoxin
AFERRID_24450	COG1151	hydroxylamine reductase activity
AFERRID_24480	COG3002	Belongs to the UPF0753 family
AFERRID_24490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFERRID_24500	COG0247	lactate metabolic process
AFERRID_24510	COG0277	FAD linked oxidase domain protein
AFERRID_24520	COG0277	FAD linked oxidase domain protein
AFERRID_24590	COG0418	dihydroorotase activity
AFERRID_24600	COG0129	dihydroxy-acid dehydratase activity
AFERRID_24610	COG0009	L-threonylcarbamoyladenylate synthase
AFERRID_24630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFERRID_24680	COG1192	Involved in chromosome partitioning
AFERRID_24800	COG1850	ribulose-bisphosphate carboxylase activity
AFERRID_24830	COG3701	Conjugal transfer protein
AFERRID_24930	COG3300	MHYT domain
AFERRID_24930	COG5001	Diguanylate cyclase
AFERRID_25060	COG0625	glutathione transferase activity
AFERRID_25090	COG1733	regulation of RNA biosynthetic process
AFERRID_25150	COG1475	DNA binding
AFERRID_25160	COG1192	Involved in chromosome partitioning
AFERRID_25190	COG0667	Aldo Keto reductase
AFERRID_25290	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFERRID_25320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFERRID_25340	COG4372	Transposase
AFERRID_25370	COG0625	glutathione transferase activity
AFERRID_25460	COG4372	Transposase
AFERRID_25540	COG0438	transferase activity, transferring glycosyl groups
AFERRID_25550	COG0670	Belongs to the BI1 family
AFERRID_25600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AFERRID_25610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFERRID_25620	COG1428	Deoxynucleoside kinase
AFERRID_25640	COG0617	tRNA 3'-terminal CCA addition
AFERRID_25660	COG0463	Glycosyl transferase, family 2
AFERRID_25680	COG0519	Catalyzes the synthesis of GMP from XMP
AFERRID_25680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFERRID_25690	COG0582	viral genome integration into host DNA
AFERRID_25760	COG1484	DNA-dependent DNA replication
AFERRID_25790	COG0629	single-stranded DNA binding
AFERRID_25860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFERRID_25860	COG0784	Response regulator, receiver
AFERRID_25920	COG0776	regulation of translation
AFERRID_25940	COG0776	regulation of translation
AFERRID_25960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFERRID_26000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFERRID_26030	COG1215	transferase activity, transferring glycosyl groups
AFERRID_26150	COG1671	Belongs to the UPF0178 family
AFERRID_26160	COG2826	transposase and inactivated derivatives, IS30 family
AFERRID_26170	COG0776	regulation of translation
AFERRID_26200	COG0393	Putative heavy-metal-binding
AFERRID_26300	COG4372	Transposase
AFERRID_26430	COG4962	Type ii secretion system protein e
AFERRID_26480	COG3451	type IV secretory pathway VirB4
AFERRID_26560	COG4372	Transposase
AFERRID_26600	COG3701	Conjugal transfer protein
AFERRID_26830	COG0625	glutathione transferase activity
AFERRID_26860	COG1733	regulation of RNA biosynthetic process
AFERRID_26950	COG1475	DNA binding
AFERRID_26960	COG1192	Involved in chromosome partitioning
AFERRID_27060	COG3657	addiction module killer protein
AFERRID_27070	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFERRID_27100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFERRID_27130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFERRID_27130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFERRID_27170	COG3384	dioxygenase
AFERRID_27180	COG1902	pentaerythritol trinitrate reductase activity
AFERRID_27200	COG1741	Belongs to the pirin family
AFERRID_27210	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFERRID_27220	COG2259	Doxx family
AFERRID_27260	COG0589	response to stress
AFERRID_27270	COG4221	oxidoreductase activity
AFERRID_27280	COG0667	Aldo Keto reductase
AFERRID_27340	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AFERRID_27350	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AFERRID_27360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFERRID_27380	COG0243	molybdopterin cofactor binding
AFERRID_27390	COG2084	Dehydrogenase
AFERRID_27410	COG0589	response to stress
AFERRID_27420	COG2814	Major facilitator Superfamily
AFERRID_27510	COG0531	amino acid
AFERRID_27520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFERRID_27530	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AFERRID_27530	COG3264	Mechanosensitive ion channel
AFERRID_27570	COG0009	L-threonylcarbamoyladenylate synthase
AFERRID_27580	COG1994	Peptidase M50
AFERRID_27590	COG0180	Tryptophanyl-tRNA synthetase
AFERRID_27600	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AFERRID_27610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AFERRID_27630	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFERRID_27640	COG1187	pseudouridine synthase activity
AFERRID_27650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFERRID_27680	COG2814	Major facilitator Superfamily
AFERRID_27760	COG1105	Belongs to the carbohydrate kinase PfkB family
AFERRID_27770	COG0280	phosphate acetyltransferase
AFERRID_27780	COG0477	Major facilitator Superfamily
AFERRID_27790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AFERRID_27800	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFERRID_27810	COG0022	dehydrogenase e1 component
AFERRID_27820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AFERRID_27840	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AFERRID_27850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFERRID_27850	COG0574	Belongs to the PEP-utilizing enzyme family
AFERRID_27880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFERRID_27890	COG2171	N-acyltransferase activity
AFERRID_27930	COG0546	phosphoglycolate phosphatase activity
AFERRID_27940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFERRID_27950	COG0402	S-adenosylhomocysteine deaminase activity
AFERRID_27970	COG0791	NLP P60 protein
AFERRID_28070	COG0732	type I restriction modification DNA specificity domain
AFERRID_28150	COG0596	Alpha beta hydrolase
AFERRID_28180	COG3153	acetyltransferase
AFERRID_28300	COG4372	Transposase
AFERRID_28370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFERRID_28400	COG0587	DNA-directed DNA polymerase activity
AFERRID_28420	COG0308	aminopeptidase N
AFERRID_28450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AFERRID_28460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AFERRID_28470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFERRID_28480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFERRID_28510	COG0424	maF-like protein
AFERRID_28520	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AFERRID_28530	COG1923	regulation of RNA biosynthetic process
AFERRID_28540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFERRID_28550	COG0330	HflC and HflK could
AFERRID_28560	COG0330	HflC and HflK could
AFERRID_28570	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AFERRID_28580	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AFERRID_28620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFERRID_28630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFERRID_28640	COG1058	Belongs to the CinA family
AFERRID_28640	COG1546	Belongs to the CinA family
AFERRID_28650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AFERRID_28660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFERRID_28680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AFERRID_28690	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFERRID_28720	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AFERRID_28730	COG0416	fatty acid biosynthetic process
AFERRID_28740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFERRID_28750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AFERRID_28760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AFERRID_28780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFERRID_28790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AFERRID_28810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AFERRID_28820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFERRID_28860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AFERRID_28870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AFERRID_28880	COG0004	ammonium transporteR
AFERRID_28890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFERRID_28890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AFERRID_28900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFERRID_28920	COG0802	atpase or kinase
AFERRID_28930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AFERRID_28940	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AFERRID_28960	COG0105	UTP biosynthetic process
AFERRID_28970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFERRID_28990	COG1426	Protein conserved in bacteria
AFERRID_29000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AFERRID_29010	COG0124	histidyl-tRNA synthetase
AFERRID_29040	COG1160	GTP binding
AFERRID_29140	COG0730	response to heat
AFERRID_29320	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFERRID_29350	COG1881	PFAM PEBP family protein
AFERRID_29360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AFERRID_29400	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AFERRID_29420	COG1216	Glycosyl transferase, family 2
AFERRID_29470	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AFERRID_29480	COG1028	Short-chain dehydrogenase reductase Sdr
AFERRID_29530	COG0729	surface antigen
AFERRID_29570	COG4654	Cytochrome c, class I
AFERRID_29620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFERRID_29640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFERRID_29670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFERRID_29680	COG1469	GTP cyclohydrolase I activity
AFERRID_29690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFERRID_29700	COG0142	geranyltranstransferase activity
AFERRID_29720	COG2223	nitrite transmembrane transporter activity
AFERRID_29740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFERRID_29750	COG1570	exodeoxyribonuclease VII activity
AFERRID_29760	COG4993	Dehydrogenase
AFERRID_29760	COG2010	Cytochrome c
AFERRID_29790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFERRID_29800	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AFERRID_29810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFERRID_29820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFERRID_29870	COG0583	DNA-binding transcription factor activity
AFERRID_29880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFERRID_29900	COG2197	response regulator
AFERRID_29920	COG3916	Acyl-homoserine-lactone synthase
AFERRID_30000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFERRID_30060	COG1132	(ABC) transporter
AFERRID_30080	COG2217	Heavy metal translocating P-type atpase
AFERRID_30120	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AFERRID_30130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AFERRID_30140	COG0640	Transcriptional regulator
AFERRID_30150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AFERRID_30190	COG3504	Conjugal transfer protein
AFERRID_30230	COG3846	protein secretion by the type IV secretion system
AFERRID_t00250	COG0156	8-amino-7-oxononanoate synthase activity