locus-tag	class	description
H2515_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H2515_00010	COG0592	DNA-directed DNA polymerase activity
H2515_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H2515_00020	COG0187	DNA topoisomerase II activity
H2515_00035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H2515_00040	COG2894	cell division
H2515_00045	COG0850	regulation of cytokinetic process
H2515_00060	COG2922	Belongs to the Smg family
H2515_00065	COG0758	DNA mediated transformation
H2515_00070	COG1388	LysM domain
H2515_00070	COG1705	Flagellar rod assembly protein muramidase FlgJ
H2515_00075	COG0242	peptide deformylase activity
H2515_00080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H2515_00085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H2515_00095	COG5000	phosphorelay sensor kinase activity
H2515_00100	COG2204	response regulator
H2515_00120	COG3459	Glycosyltransferase 36 associated
H2515_00135	COG1393	Belongs to the ArsC family
H2515_00155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H2515_00160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H2515_00165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H2515_00170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H2515_00175	COG2833	Protein of unknown function (DUF455)
H2515_00180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2515_00185	COG2161	toxin-antitoxin pair type II binding
H2515_00190	COG4115	mRNA cleavage
H2515_00220	COG3344	reverse transcriptase
H2515_00250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2515_00275	COG1914	H( )-stimulated, divalent metal cation uptake system
H2515_00280	COG1842	Phage shock protein A
H2515_00285	COG0393	Putative heavy-metal-binding
H2515_00315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2515_00320	COG4521	taurine ABC transporter
H2515_00360	COG2188	Transcriptional regulator
H2515_00375	COG0583	DNA-binding transcription factor activity
H2515_00395	COG0277	FAD linked oxidase domain protein
H2515_00400	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H2515_00405	COG0792	nuclease activity
H2515_00410	COG3107	peptidoglycan biosynthetic process
H2515_00435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H2515_00440	COG1278	Cold shock
H2515_00455	COG1530	ribonuclease E activity
H2515_00460	COG0424	maF-like protein
H2515_00475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H2515_00485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H2515_00495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H2515_00510	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H2515_00525	COG0811	peptide transport
H2515_00565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2515_00570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_00575	COG1074	ATP-dependent DNA helicase activity
H2515_00580	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H2515_00590	COG3220	belongs to the UPF0276 family
H2515_00600	COG1560	Kdo2-lipid A biosynthetic process
H2515_00615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H2515_00625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2515_00635	COG3260	NADH ubiquinone oxidoreductase 20
H2515_00640	COG3261	NADH dehydrogenase
H2515_00640	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H2515_00645	COG0651	ATP synthesis coupled electron transport
H2515_00695	COG2885	chlorophyll binding
H2515_00705	COG0602	queuosine metabolic process
H2515_00710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H2515_00715	COG0823	Involved in the tonB-independent uptake of proteins
H2515_00730	COG0811	peptide transport
H2515_00735	COG0824	Thioesterase
H2515_00740	COG2255	four-way junction helicase activity
H2515_00745	COG0632	four-way junction helicase activity
H2515_00750	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H2515_00755	COG0217	transcriptional regulatory protein
H2515_00765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H2515_00770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H2515_00780	COG2095	MarC family integral membrane protein
H2515_00790	COG0488	(ABC) transporter
H2515_00795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H2515_00805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H2515_00810	COG0706	membrane insertase activity
H2515_00815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H2515_00850	COG1131	(ABC) transporter
H2515_00855	COG2945	thiolester hydrolase activity
H2515_00870	COG1959	2 iron, 2 sulfur cluster binding
H2515_00880	COG0134	indole-3-glycerol-phosphate synthase activity
H2515_00885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H2515_00955	COG0393	Putative heavy-metal-binding
H2515_01000	COG1104	cysteine desulfurase activity
H2515_01005	COG2226	methyltransferase
H2515_01025	COG2226	methyltransferase
H2515_01100	COG0629	single-stranded DNA binding
H2515_01120	COG0714	Associated with various cellular activities
H2515_01140	COG1994	Peptidase M50
H2515_01215	COG0457	Tetratricopeptide repeat
H2515_01235	COG0776	regulation of translation
H2515_01250	COG1487	ribonuclease activity
H2515_01285	COG4974	Belongs to the 'phage' integrase family
H2515_01340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2515_01405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2515_01410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2515_01440	COG2217	Heavy metal translocating P-type atpase
H2515_01470	COG4974	Belongs to the 'phage' integrase family
H2515_01610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2515_01715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2515_01720	COG0305	Participates in initiation and elongation during chromosome replication
H2515_01750	COG0582	viral genome integration into host DNA
H2515_01780	COG0546	phosphoglycolate phosphatase activity
H2515_01785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H2515_01795	COG0469	pyruvate kinase activity
H2515_01800	COG0126	phosphoglycerate kinase activity
H2515_01805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2515_01810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H2515_01815	COG1494	fructose-1,6-bisphosphatase
H2515_01820	COG0483	inositol monophosphate 1-phosphatase activity
H2515_01830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2515_01835	COG0598	Magnesium transport protein CorA
H2515_01840	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H2515_01845	COG1322	Protein conserved in bacteria
H2515_01850	COG1970	mechanosensitive ion channel activity
H2515_01865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2515_01955	COG0165	Argininosuccinate lyase
H2515_01970	COG0166	Belongs to the GPI family
H2515_01975	COG1686	Belongs to the peptidase S11 family
H2515_01980	COG0655	NAD(P)H dehydrogenase (quinone) activity
H2515_01985	COG1733	regulation of RNA biosynthetic process
H2515_01990	COG2353	YceI-like domain
H2515_02015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2515_02040	COG0519	Catalyzes the synthesis of GMP from XMP
H2515_02040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2515_02050	COG0004	ammonium transporteR
H2515_02065	COG0004	ammonium transporteR
H2515_02070	COG0347	Belongs to the P(II) protein family
H2515_02080	COG2719	SpoVR family
H2515_02085	COG2718	Belongs to the UPF0229 family
H2515_02090	COG0004	ammonium transporteR
H2515_02095	COG2766	serine protein kinase
H2515_02115	COG2308	Evidence 4 Homologs of previously reported genes of
H2515_02125	COG3852	Histidine kinase
H2515_02140	COG0142	geranyltranstransferase activity
H2515_02170	COG0488	(ABC) transporter
H2515_02180	COG1573	uracil-dna glycosylase
H2515_02200	COG0517	IMP dehydrogenase activity
H2515_02270	COG0028	Belongs to the TPP enzyme family
H2515_02285	COG4584	PFAM Integrase catalytic
H2515_02305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H2515_02310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H2515_02315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H2515_02335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H2515_02340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2515_02350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2515_02355	COG0735	belongs to the Fur family
H2515_02360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H2515_02365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H2515_02370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H2515_02375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H2515_02380	COG0659	secondary active sulfate transmembrane transporter activity
H2515_02385	COG0288	reversible hydration of carbon dioxide
H2515_02390	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H2515_02395	COG2226	methyltransferase
H2515_02405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2515_02405	COG2813	Specifically methylates the guanine in position
H2515_02410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2515_02420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H2515_02425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H2515_02430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2515_02430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2515_02445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H2515_02470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H2515_02495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2515_02515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H2515_02520	COG0081	regulation of translation
H2515_02525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H2515_02530	COG0222	ribosome binding
H2515_02535	COG0085	RNA polymerase activity
H2515_02540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H2515_02545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H2515_02550	COG0049	tRNA binding
H2515_02555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H2515_02560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H2515_02565	COG0051	transcription antitermination factor activity, RNA binding
H2515_02570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H2515_02575	COG0088	Forms part of the polypeptide exit tunnel
H2515_02580	COG0089	rRNA binding
H2515_02585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H2515_02590	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H2515_02595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H2515_02605	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H2515_02610	COG0255	Belongs to the universal ribosomal protein uL29 family
H2515_02615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H2515_02620	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H2515_02625	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H2515_02630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H2515_02635	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H2515_02640	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H2515_02645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H2515_02650	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H2515_02655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H2515_02660	COG1841	ribosomal large subunit assembly
H2515_02665	COG0200	Binds to the 23S rRNA
H2515_02670	COG0201	protein transport
H2515_02675	COG0563	adenylate kinase activity
H2515_02680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H2515_02685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H2515_02690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H2515_02695	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H2515_02700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H2515_02705	COG0202	RNA polymerase activity
H2515_02710	COG0203	ribosomal protein L17
H2515_02715	COG0756	dUTP diphosphatase activity
H2515_02720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H2515_02725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2515_02745	COG1028	Short-chain dehydrogenase reductase Sdr
H2515_02745	COG0604	alcohol dehydrogenase
H2515_02745	COG3321	synthase
H2515_02775	COG1216	Glycosyl transferase, family 2
H2515_02775	COG0438	transferase activity, transferring glycosyl groups
H2515_02845	COG2003	Belongs to the UPF0758 family
H2515_02855	COG0671	phosphoesterase, PA-phosphatase related
H2515_02875	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H2515_02885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2515_02890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2515_02890	COG0678	peroxiredoxin activity
H2515_02895	COG0560	Phosphoserine phosphatase
H2515_02900	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H2515_02905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H2515_02910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H2515_02915	COG0585	pseudouridine synthase activity
H2515_02930	COG0492	ferredoxin-NADP+ reductase activity
H2515_02940	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H2515_02950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H2515_02955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H2515_02965	COG1376	ErfK ybiS ycfS ynhG family protein
H2515_03000	COG0779	Required for maturation of 30S ribosomal subunits
H2515_03005	COG0195	Participates in both transcription termination and antitermination
H2515_03005	COG2251	uridine kinase activity
H2515_03010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H2515_03015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H2515_03020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H2515_03025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H2515_03030	COG1185	polyribonucleotide nucleotidyltransferase activity
H2515_03035	COG0612	Peptidase, M16
H2515_03040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2515_03050	COG0328	RNA-DNA hybrid ribonuclease activity
H2515_03055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2515_03060	COG0346	lactoylglutathione lyase activity
H2515_03070	COG0137	argininosuccinate synthase activity
H2515_03075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H2515_03080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2515_03085	COG0527	aspartate kinase activity
H2515_03105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2515_03105	COG1648	precorrin-2 dehydrogenase activity
H2515_03110	COG2895	sulfate adenylyltransferase (ATP) activity
H2515_03120	COG0175	sulfate reduction
H2515_03125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2515_03130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H2515_03145	COG1252	NADH dehydrogenase
H2515_03185	COG3002	Belongs to the UPF0753 family
H2515_03230	COG0418	dihydroorotase activity
H2515_03235	COG0129	dihydroxy-acid dehydratase activity
H2515_03260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2515_03275	COG0191	fructose-bisphosphate aldolase activity
H2515_03290	COG1192	Involved in chromosome partitioning
H2515_03305	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H2515_03310	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H2515_03315	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H2515_03360	COG0667	Aldo Keto reductase
H2515_03475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2515_03480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2515_03485	COG1845	cytochrome c oxidase, subunit III
H2515_03530	COG0251	oxidation-reduction process
H2515_03535	COG1126	abc transporter atp-binding protein
H2515_03590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2515_03595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2515_03595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H2515_03600	COG0312	modulator of DNA gyrase
H2515_03605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2515_03610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H2515_03615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2515_03620	COG0149	triose-phosphate isomerase activity
H2515_03635	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2515_03640	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2515_03645	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2515_03650	COG0649	NAD binding
H2515_03655	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H2515_03660	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H2515_03665	COG1034	ATP synthesis coupled electron transport
H2515_03670	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H2515_03675	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2515_03685	COG0713	ATP synthesis coupled electron transport
H2515_03700	COG1007	ATP synthesis coupled electron transport
H2515_03715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H2515_03720	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H2515_03725	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H2515_03730	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H2515_03735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H2515_03740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2515_03740	COG0072	phenylalanine-tRNA ligase activity
H2515_03745	COG0776	regulation of translation
H2515_03795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2515_03815	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H2515_03820	COG2154	pterin-4-alpha-carbinolamine dehydratase
H2515_03845	COG0204	Acyl-transferase
H2515_03850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H2515_03855	COG0751	glycine-tRNA ligase activity
H2515_03900	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H2515_03905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H2515_03910	COG0321	lipoyl(octanoyl) transferase activity
H2515_03920	COG1686	Belongs to the peptidase S11 family
H2515_03925	COG0772	Belongs to the SEDS family
H2515_03940	COG1792	Involved in formation and maintenance of cell shape
H2515_03945	COG1077	Cell shape determining protein MreB Mrl
H2515_03950	COG0737	Belongs to the 5'-nucleotidase family
H2515_03955	COG3439	Domain of unknown function DUF302
H2515_03980	COG3852	Histidine kinase
H2515_03990	COG0315	cyclic pyranopterin monophosphate synthase activity
H2515_04000	COG0243	molybdopterin cofactor binding
H2515_04005	COG0437	4 iron, 4 sulfur cluster binding
H2515_04015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H2515_04020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2515_04025	COG0425	Belongs to the sulfur carrier protein TusA family
H2515_04030	COG2210	Belongs to the sulfur carrier protein TusA family
H2515_04060	COG2048	Heterodisulfide reductase, subunit B
H2515_04065	COG0509	glycine decarboxylation via glycine cleavage system
H2515_04075	COG0509	glycine decarboxylation via glycine cleavage system
H2515_04085	COG0095	Lipoate-protein ligase
H2515_04090	COG0644	oxidoreductase
H2515_04140	COG0123	including yeast histone deacetylase and acetoin utilization protein
H2515_04155	COG0583	DNA-binding transcription factor activity
H2515_04170	COG0586	Pfam SNARE associated Golgi protein
H2515_04175	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H2515_04190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H2515_04210	COG0791	NLP P60 protein
H2515_04230	COG1199	ATP-dependent helicase activity
H2515_04265	COG2960	long-chain fatty acid transporting porin activity
H2515_04270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2515_04275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2515_04280	COG0084	hydrolase, TatD family'
H2515_04285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H2515_04300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H2515_04310	COG0640	Transcriptional regulator
H2515_04320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2515_04340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2515_04350	COG0860	N-Acetylmuramoyl-L-alanine amidase
H2515_04355	COG1272	protein, Hemolysin III
H2515_04365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2515_04375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H2515_04380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H2515_04385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H2515_04385	COG0047	phosphoribosylformylglycinamidine synthase activity
H2515_04395	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
H2515_04410	COG4691	Plasmid stability protein
H2515_04440	COG1686	Belongs to the peptidase S11 family
H2515_04460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H2515_04475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H2515_04480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H2515_04485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H2515_04490	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H2515_04500	COG1193	negative regulation of DNA recombination
H2515_04525	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H2515_04530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H2515_04540	COG0243	molybdopterin cofactor binding
H2515_04570	COG0529	Catalyzes the synthesis of activated sulfate
H2515_04570	COG2046	Belongs to the sulfate adenylyltransferase family
H2515_04575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H2515_04590	COG0459	protein refolding
H2515_04595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H2515_04605	COG4232	protein-disulfide reductase activity
H2515_04620	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H2515_04630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2515_04640	COG4178	(ABC) transporter
H2515_04660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H2515_04665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H2515_04670	COG0196	riboflavin kinase activity
H2515_04685	COG1538	Outer membrane efflux protein
H2515_04755	COG4974	Belongs to the 'phage' integrase family
H2515_04770	COG2197	response regulator
H2515_04800	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2515_04860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H2515_04875	COG1846	Transcriptional regulator
H2515_04885	COG2353	YceI-like domain
H2515_04935	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
H2515_04985	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H2515_04995	COG0671	phosphoesterase, PA-phosphatase related
H2515_05015	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H2515_05055	COG1484	DNA-dependent DNA replication
H2515_05100	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H2515_05100	COG1672	PFAM Archaeal ATPase
H2515_05215	COG0631	protein serine/threonine phosphatase activity
H2515_05325	COG0776	regulation of translation
H2515_05330	COG0842	Transport permease protein
H2515_05335	COG0842	Transport permease protein
H2515_05340	COG1131	(ABC) transporter
H2515_05350	COG1850	ribulose-bisphosphate carboxylase activity
H2515_05380	COG1561	YicC-like family, N-terminal region
H2515_05385	COG0194	GDP metabolic process
H2515_05390	COG1758	RNA polymerase activity
H2515_05395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2515_05425	COG0628	permease
H2515_05450	COG1355	regulation of microtubule-based process
H2515_05455	COG2078	PFAM AMMECR1 domain protein
H2515_05470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2515_05475	COG0303	'Molybdopterin
H2515_05480	COG1763	Mo-molybdopterin cofactor biosynthetic process
H2515_05485	COG0746	molybdenum cofactor guanylyltransferase activity
H2515_05500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H2515_05515	COG0135	phosphoribosylanthranilate isomerase activity
H2515_05520	COG0133	tryptophan synthase activity
H2515_05525	COG0159	tryptophan synthase activity
H2515_05530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H2515_05535	COG0285	dihydrofolate synthase activity
H2515_05545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H2515_05560	COG1253	flavin adenine dinucleotide binding
H2515_05565	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H2515_05570	COG0343	queuine tRNA-ribosyltransferase activity
H2515_05575	COG1862	Preprotein translocase
H2515_05580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2515_05635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2515_05665	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H2515_05670	COG0493	'glutamate synthase
H2515_05675	COG0067	glutamate synthase
H2515_05675	COG0069	glutamate synthase activity
H2515_05675	COG0070	glutamate synthase
H2515_05680	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H2515_05685	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H2515_05690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H2515_05695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H2515_05730	COG0432	Pfam Uncharacterised protein family UPF0047
H2515_05740	COG1193	negative regulation of DNA recombination
H2515_05745	COG0028	Belongs to the TPP enzyme family
H2515_05755	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H2515_05760	COG0688	phosphatidylethanolamine metabolic process
H2515_05765	COG1183	phosphatidylcholine synthase activity
H2515_05775	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2515_05860	COG0642	Histidine kinase
H2515_05875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2515_05885	COG0187	DNA topoisomerase II activity
H2515_05900	COG0741	lytic transglycosylase activity
H2515_05905	COG1741	Belongs to the pirin family
H2515_05920	COG0243	molybdopterin cofactor binding
H2515_05935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2515_05965	COG3707	response regulator
H2515_05975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2515_05975	COG1648	precorrin-2 dehydrogenase activity
H2515_05980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H2515_05985	COG0243	molybdopterin cofactor binding
H2515_05990	COG2146	nitrite reductase [NAD(P)H] activity
H2515_05995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2515_06005	COG2223	nitrite transmembrane transporter activity
H2515_06010	COG1116	anion transmembrane transporter activity
H2515_06010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2515_06020	COG3189	MarR family transcriptional regulator
H2515_06025	COG0509	glycine decarboxylation via glycine cleavage system
H2515_06050	COG1566	PFAM secretion protein HlyD family protein
H2515_06065	COG0583	DNA-binding transcription factor activity
H2515_06105	COG0670	Belongs to the BI1 family
H2515_06120	COG1193	negative regulation of DNA recombination
H2515_06130	COG0277	FAD linked oxidase domain protein
H2515_06135	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H2515_06140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H2515_06145	COG1428	Deoxynucleoside kinase
H2515_06150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H2515_06155	COG0617	tRNA 3'-terminal CCA addition
H2515_06155	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H2515_06155	COG3620	sequence-specific DNA binding
H2515_06165	COG0463	Glycosyl transferase, family 2
H2515_06175	COG0519	Catalyzes the synthesis of GMP from XMP
H2515_06175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2515_06180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H2515_06185	COG3264	Mechanosensitive ion channel
H2515_06185	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H2515_06205	COG0009	L-threonylcarbamoyladenylate synthase
H2515_06210	COG1994	Peptidase M50
H2515_06215	COG0180	Tryptophanyl-tRNA synthetase
H2515_06220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H2515_06225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H2515_06230	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2515_06235	COG1187	pseudouridine synthase activity
H2515_06265	COG1215	transferase activity, transferring glycosyl groups
H2515_06275	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H2515_06290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H2515_06305	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2515_06315	COG1105	Belongs to the carbohydrate kinase PfkB family
H2515_06320	COG0280	phosphate acetyltransferase
H2515_06325	COG0477	Major facilitator Superfamily
H2515_06330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H2515_06335	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2515_06340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H2515_06345	COG0574	Belongs to the PEP-utilizing enzyme family
H2515_06345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2515_06360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H2515_06365	COG2171	N-acyltransferase activity
H2515_06370	COG0436	Aminotransferase
H2515_06380	COG0811	peptide transport
H2515_06385	COG0848	biopolymer transport protein
H2515_06405	COG0440	acetolactate synthase activity
H2515_06410	COG0039	L-malate dehydrogenase activity
H2515_06420	COG4166	transmembrane transport
H2515_06425	COG0601	transmembrane transport
H2515_06430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2515_06435	COG0444	Belongs to the ABC transporter superfamily
H2515_06470	COG1132	(ABC) transporter
H2515_06485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H2515_06490	COG0402	S-adenosylhomocysteine deaminase activity
H2515_06500	COG0791	NLP P60 protein
H2515_06500	COG0741	lytic transglycosylase activity
H2515_06510	COG2363	Small membrane protein
H2515_06535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2515_06540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2515_06565	COG0109	protoheme IX farnesyltransferase activity
H2515_06570	COG2814	Major facilitator Superfamily
H2515_06585	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H2515_06610	COG1333	cytochrome c biogenesis protein
H2515_06645	COG2915	High frequency lysogenization protein hflD homolog
H2515_06650	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H2515_06655	COG0024	Methionine aminopeptidase
H2515_06660	COG1489	DNA binding
H2515_06665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2515_06675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H2515_06680	COG1546	Belongs to the CinA family
H2515_06680	COG1058	Belongs to the CinA family
H2515_06685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H2515_06690	COG2137	regulation of response to DNA damage stimulus
H2515_06715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2515_06730	COG0488	(ABC) transporter
H2515_06750	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H2515_06770	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H2515_06775	COG2204	response regulator
H2515_06790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2515_06805	COG2943	transferase activity, transferring hexosyl groups
H2515_06805	COG3416	Protein conserved in bacteria
H2515_06820	COG2363	Small membrane protein
H2515_06830	COG0616	signal peptide processing
H2515_06835	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H2515_06840	COG0314	molybdopterin synthase activity
H2515_06845	COG1666	GTP binding
H2515_06850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H2515_06860	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2515_06865	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H2515_06870	COG0714	Associated with various cellular activities
H2515_06885	COG1132	(ABC) transporter
H2515_06890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H2515_06895	COG0450	alkyl hydroperoxide reductase
H2515_06905	COG0613	PHP domain protein
H2515_06910	COG0628	permease
H2515_06930	COG0084	hydrolase, TatD family'
H2515_06935	COG0321	lipoyl(octanoyl) transferase activity
H2515_06935	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H2515_06965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H2515_06980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2515_06985	COG0481	GTPase activity
H2515_06990	COG0681	Belongs to the peptidase S26 family
H2515_07000	COG0571	ribonuclease III activity
H2515_07005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H2515_07010	COG1381	Involved in DNA repair and RecF pathway recombination
H2515_07015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H2515_07020	COG0736	holo-[acyl-carrier-protein] synthase activity
H2515_07030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H2515_07030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H2515_07035	COG0037	tRNA processing
H2515_07040	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H2515_07085	COG0729	surface antigen
H2515_07090	COG2911	Protein conserved in bacteria
H2515_07120	COG0542	response to heat
H2515_07140	COG4584	PFAM Integrase catalytic
H2515_07185	COG1518	maintenance of DNA repeat elements
H2515_07225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2515_07235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2515_07240	COG0438	transferase activity, transferring glycosyl groups
H2515_07255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H2515_07260	COG1469	GTP cyclohydrolase I activity
H2515_07265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H2515_07270	COG0142	geranyltranstransferase activity
H2515_07275	COG1722	exodeoxyribonuclease VII activity
H2515_07280	COG2223	nitrite transmembrane transporter activity
H2515_07290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H2515_07295	COG1570	exodeoxyribonuclease VII activity
H2515_07305	COG0531	amino acid
H2515_07310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H2515_07315	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2515_07320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2515_07340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2515_07355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H2515_07360	COG1846	Transcriptional regulator
H2515_07375	COG1846	Transcriptional regulator
H2515_07430	COG0300	oxidoreductase activity
H2515_07445	COG4974	Belongs to the 'phage' integrase family
H2515_07460	COG2353	YceI-like domain
H2515_07485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2515_07500	COG5654	RES domain protein
H2515_07505	COG0438	transferase activity, transferring glycosyl groups
H2515_07510	COG0438	transferase activity, transferring glycosyl groups
H2515_07535	COG1012	belongs to the aldehyde dehydrogenase family
H2515_07560	COG0633	Ferredoxin
H2515_07565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2515_07575	COG5554	nitrogen fixation
H2515_07580	COG1104	cysteine desulfurase activity
H2515_07610	COG0316	Belongs to the HesB IscA family
H2515_07615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2515_07645	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H2515_07655	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H2515_07670	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H2515_07675	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H2515_07690	COG5420	small protein containing a coiled-coil domain
H2515_07760	COG2146	nitrite reductase [NAD(P)H] activity
H2515_07790	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H2515_07825	COG1166	arginine decarboxylase activity
H2515_07830	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H2515_07835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H2515_07855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H2515_07860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H2515_07870	COG1196	nuclear chromosome segregation
H2515_07875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H2515_07910	COG1215	transferase activity, transferring glycosyl groups
H2515_07915	COG1215	transferase activity, transferring glycosyl groups
H2515_07925	COG0784	Response regulator, receiver
H2515_07925	COG2198	Histidine kinase
H2515_07925	COG2205	protein histidine kinase activity
H2515_07930	COG1024	Enoyl-CoA hydratase
H2515_07940	COG0457	Tetratricopeptide repeat
H2515_07940	COG3118	belongs to the thioredoxin family
H2515_07945	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H2515_07990	COG0326	Molecular chaperone. Has ATPase activity
H2515_08140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2515_08155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H2515_08210	COG1160	GTP binding
H2515_08225	COG0124	histidyl-tRNA synthetase
H2515_08230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H2515_08235	COG1426	Protein conserved in bacteria
H2515_08245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H2515_08250	COG0105	UTP biosynthetic process
H2515_08255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H2515_08260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H2515_08265	COG0802	atpase or kinase
H2515_08275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H2515_08280	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H2515_08280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H2515_08285	COG0004	ammonium transporteR
H2515_08290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H2515_08295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H2515_08300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H2515_08325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H2515_08330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H2515_08340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2515_08345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2515_08355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H2515_08360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H2515_08365	COG0416	fatty acid biosynthetic process
H2515_08370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H2515_08380	COG1295	ribonuclease BN
H2515_08380	COG1959	2 iron, 2 sulfur cluster binding
H2515_08385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H2515_08390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H2515_08400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H2515_08405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H2515_08410	COG1546	Belongs to the CinA family
H2515_08410	COG1058	Belongs to the CinA family
H2515_08415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2515_08420	COG2326	polyphosphate kinase activity
H2515_08450	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H2515_08455	COG0330	HflC and HflK could
H2515_08460	COG0330	HflC and HflK could
H2515_08465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H2515_08470	COG1923	regulation of RNA biosynthetic process
H2515_08475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H2515_08480	COG0424	maF-like protein
H2515_08495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2515_08500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2515_08505	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H2515_08520	COG3025	triphosphatase activity
H2515_08530	COG0308	aminopeptidase N
H2515_08540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2515_08550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2515_08570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H2515_08575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H2515_08580	COG0740	serine-type endopeptidase activity
H2515_08585	COG0544	peptidyl-prolyl cis-trans isomerase activity
H2515_08590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H2515_08595	COG0284	orotidine-5'-phosphate decarboxylase activity
H2515_08600	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H2515_08605	COG0776	regulation of translation
H2515_08615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H2515_08620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H2515_08630	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H2515_08635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H2515_08645	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H2515_08655	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H2515_08660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H2515_08735	COG0439	Biotin carboxylase
H2515_08740	COG3665	Urea carboxylase-associated protein
H2515_08750	COG1116	anion transmembrane transporter activity
H2515_08755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2515_08765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2515_08775	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_08780	COG3657	addiction module killer protein
H2515_08810	COG1192	Involved in chromosome partitioning
H2515_08815	COG1475	DNA binding
H2515_08855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H2515_08885	COG0776	regulation of translation
H2515_08935	COG3701	Conjugal transfer protein
H2515_08945	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_08995	COG4962	Type ii secretion system protein e
H2515_09045	COG3311	Transcriptional regulator
H2515_09050	COG1569	PIN domain
H2515_09065	COG3077	Addiction module antitoxin, RelB DinJ family
H2515_09070	COG3041	Addiction module toxin RelE StbE family
H2515_09085	COG0629	single-stranded DNA binding
H2515_09100	COG1484	DNA-dependent DNA replication
H2515_09115	COG4197	protein conserved in bacteria, prophage-related
H2515_09135	COG4974	Belongs to the 'phage' integrase family
H2515_09180	COG1132	(ABC) transporter
H2515_09185	COG0436	Aminotransferase
H2515_09195	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H2515_09200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H2515_09230	COG0322	excinuclease ABC activity
H2515_09240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H2515_09245	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H2515_09250	COG0148	phosphopyruvate hydratase activity
H2515_09255	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H2515_09260	COG0504	CTP synthase activity
H2515_09265	COG1064	alcohol dehydrogenase
H2515_09335	COG0477	Major facilitator Superfamily
H2515_09345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2515_09345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2515_09350	COG1230	cation diffusion facilitator family transporter
H2515_09395	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H2515_09410	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H2515_09425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2515_09435	COG1215	transferase activity, transferring glycosyl groups
H2515_09450	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H2515_09455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2515_09460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2515_09465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H2515_09470	COG0037	tRNA processing
H2515_09475	COG0825	malonyl-CoA metabolic process
H2515_09485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H2515_09500	COG0673	inositol 2-dehydrogenase activity
H2515_09505	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2515_09510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H2515_09515	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2515_09535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H2515_09540	COG0575	Belongs to the CDS family
H2515_09545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2515_09555	COG0528	UMP kinase activity
H2515_09560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H2515_09565	COG0052	Belongs to the universal ribosomal protein uS2 family
H2515_09585	COG0704	Plays a role in the regulation of phosphate uptake
H2515_09590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2515_09595	COG0581	inorganic phosphate transmembrane transporter activity
H2515_09600	COG0573	inorganic phosphate transmembrane transporter activity
H2515_09605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H2515_09615	COG0745	RESPONSE REGULATOR receiver
H2515_09620	COG0513	Belongs to the DEAD box helicase family
H2515_09675	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2515_09680	COG0154	amidase activity
H2515_09685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2515_09700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H2515_09715	COG3394	polysaccharide catabolic process
H2515_09720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H2515_09730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2515_09740	COG1657	PFAM Prenyltransferase squalene oxidase
H2515_09745	COG1562	ergosterol biosynthetic process
H2515_09750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H2515_09755	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H2515_09770	COG0442	prolyl-tRNA aminoacylation
H2515_09775	COG0589	response to stress
H2515_09790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H2515_09810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H2515_09830	COG0768	penicillin binding
H2515_09835	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H2515_09840	COG0193	aminoacyl-tRNA hydrolase activity
H2515_09845	COG0012	GTP binding
H2515_09850	COG4942	peptidase
H2515_09870	COG1396	sequence-specific DNA binding
H2515_09875	COG0651	ATP synthesis coupled electron transport
H2515_09880	COG0650	Formate hydrogenlyase subunit 4
H2515_09890	COG0651	ATP synthesis coupled electron transport
H2515_09895	COG3261	NADH dehydrogenase
H2515_09895	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H2515_09900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2515_09925	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H2515_09930	COG0494	nUDIX hydrolase
H2515_09940	COG1187	pseudouridine synthase activity
H2515_09955	COG0210	DNA helicase
H2515_09960	COG0268	Binds directly to 16S ribosomal RNA
H2515_09965	COG3842	ATPase activity
H2515_09980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H2515_09985	COG0514	ATP-dependent DNA helicase (RecQ)
H2515_09990	COG1965	Belongs to the frataxin family
H2515_10015	COG0795	lipopolysaccharide-transporting ATPase activity
H2515_10020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H2515_10025	COG2927	DNA polymerase III (CHI subunit)
H2515_10035	COG0525	valine-tRNA ligase activity
H2515_10040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H2515_10060	COG0412	Dienelactone hydrolase
H2515_10065	COG1902	pentaerythritol trinitrate reductase activity
H2515_10090	COG0671	phosphoesterase, PA-phosphatase related
H2515_10095	COG1596	polysaccharide export
H2515_10100	COG3206	protein involved in exopolysaccharide biosynthesis
H2515_10100	COG0489	protein tyrosine kinase activity
H2515_10160	COG0110	maltose O-acetyltransferase activity
H2515_10165	COG0297	glycogen (starch) synthase activity
H2515_10170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2515_10185	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H2515_10185	COG0662	Cupin 2, conserved barrel domain protein
H2515_10205	COG0297	glycogen (starch) synthase activity
H2515_10225	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H2515_10235	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H2515_10250	COG3657	addiction module killer protein
H2515_10265	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
H2515_10275	COG2917	probably involved in intracellular septation
H2515_10280	COG2350	Protein conserved in bacteria
H2515_10285	COG0271	Belongs to the BolA IbaG family
H2515_10290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H2515_10290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H2515_10300	COG0129	dihydroxy-acid dehydratase activity
H2515_10305	COG0628	permease
H2515_10310	COG0281	malic enzyme
H2515_10315	COG0254	rRNA binding
H2515_10335	COG1136	(ABC) transporter
H2515_10340	COG0577	efflux transmembrane transporter activity
H2515_10355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H2515_10375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H2515_10380	COG1127	ABC transporter
H2515_10385	COG0163	prenyltransferase activity
H2515_10390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2515_10400	COG2022	thiamine diphosphate biosynthetic process
H2515_10410	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H2515_10450	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2515_10455	COG0482	sulfurtransferase activity
H2515_10470	COG0443	Heat shock 70 kDa protein
H2515_10475	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H2515_10485	COG0822	iron-sulfur transferase activity
H2515_10490	COG1104	cysteine desulfurase activity
H2515_10495	COG1959	2 iron, 2 sulfur cluster binding
H2515_10505	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H2515_10515	COG5001	Diguanylate cyclase
H2515_10515	COG3300	MHYT domain
H2515_10530	COG1530	ribonuclease E activity
H2515_10535	COG0215	cysteine-tRNA ligase activity
H2515_10540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2515_10560	COG0531	amino acid
H2515_10580	COG0745	RESPONSE REGULATOR receiver
H2515_10585	COG2205	protein histidine kinase activity
H2515_10595	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H2515_10605	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H2515_10620	COG0138	bifunctional purine biosynthesis protein purh
H2515_10625	COG0151	Belongs to the GarS family
H2515_10630	COG0009	L-threonylcarbamoyladenylate synthase
H2515_10635	COG0408	coproporphyrinogen oxidase activity
H2515_10640	COG0167	dihydroorotate dehydrogenase activity
H2515_10670	COG0811	peptide transport
H2515_10700	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H2515_10705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2515_10725	COG0033	Phosphoglucomutase
H2515_10740	COG4974	Belongs to the 'phage' integrase family
H2515_10820	COG3451	type IV secretory pathway VirB4
H2515_10845	COG1484	DNA-dependent DNA replication
H2515_10925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2515_10960	COG0697	spore germination
H2515_10965	COG0681	Belongs to the peptidase S26 family
H2515_11000	COG1475	DNA binding
H2515_11005	COG1192	Involved in chromosome partitioning
H2515_11035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H2515_11045	COG2948	multi-organism process
H2515_11055	COG3701	Conjugal transfer protein
H2515_11090	COG3451	type IV secretory pathway VirB4
H2515_11110	COG4962	Type ii secretion system protein e
H2515_11255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2515_11275	COG4372	Transposase
H2515_11315	COG3437	response regulator, receiver
H2515_11320	COG0784	Response regulator, receiver
H2515_11340	COG0776	regulation of translation
H2515_11345	COG0776	regulation of translation
H2515_11360	COG2226	methyltransferase
H2515_11365	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H2515_11380	COG1815	bacterial-type flagellum-dependent cell motility
H2515_11390	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H2515_11395	COG1749	Flagellar hook protein flgE
H2515_11415	COG1706	bacterial-type flagellum-dependent cell motility
H2515_11420	COG1705	Flagellar rod assembly protein muramidase FlgJ
H2515_11420	COG3951	Flagellar rod assembly protein muramidase FlgJ
H2515_11425	COG1256	bacterial-type flagellum assembly
H2515_11465	COG1677	Flagellar hook-basal body complex protein FliE
H2515_11505	COG1191	sigma factor activity
H2515_11540	COG1987	bacterial-type flagellum assembly
H2515_11550	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H2515_11555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H2515_11585	COG2198	Histidine kinase
H2515_11585	COG0643	Histidine kinase
H2515_11605	COG0784	Response regulator, receiver
H2515_11605	COG0835	chemotaxis
H2515_11610	COG0840	transmembrane signaling receptor activity
H2515_11635	COG1845	cytochrome c oxidase, subunit III
H2515_11640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2515_11660	COG0505	Belongs to the CarA family
H2515_11670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H2515_11675	COG1968	undecaprenyl-diphosphatase activity
H2515_11680	COG0109	protoheme IX farnesyltransferase activity
H2515_11700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2515_11705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2515_11720	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H2515_11725	COG0259	pyridoxamine-phosphate oxidase activity
H2515_11735	COG0066	3-isopropylmalate dehydratase activity
H2515_11740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H2515_11745	COG2226	methyltransferase
H2515_11760	COG0406	alpha-ribazole phosphatase activity
H2515_11770	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H2515_11775	COG1132	(ABC) transporter
H2515_11780	COG0438	transferase activity, transferring glycosyl groups
H2515_11785	COG0438	transferase activity, transferring glycosyl groups
H2515_11790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H2515_11830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2515_11840	COG1121	(ABC) transporter
H2515_11850	COG0312	modulator of DNA gyrase
H2515_11855	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H2515_11860	COG4535	Mg2 and Co2 transporter CorC
H2515_11865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H2515_11870	COG1702	phosphate starvation-inducible protein PhoH
H2515_11875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H2515_11885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H2515_11895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H2515_11900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H2515_11905	COG1278	Cold shock
H2515_11935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H2515_11940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H2515_11950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2515_11955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H2515_11965	COG0058	SHG alpha-glucan phosphorylase activity
H2515_11970	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H2515_11980	COG0793	Belongs to the peptidase S41A family
H2515_11985	COG0693	protein deglycase activity
H2515_11990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2515_11995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H2515_12000	COG0542	response to heat
H2515_12005	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H2515_12010	COG1573	uracil-dna glycosylase
H2515_12020	COG4453	Protein conserved in bacteria
H2515_12035	COG3344	reverse transcriptase
H2515_12065	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H2515_12070	COG2835	tetraacyldisaccharide 4'-kinase activity
H2515_12075	COG1663	tetraacyldisaccharide 4'-kinase activity
H2515_12090	COG0848	biopolymer transport protein
H2515_12095	COG0811	peptide transport
H2515_12100	COG0658	competence protein
H2515_12100	COG2333	competence protein COMEC
H2515_12110	COG1136	(ABC) transporter
H2515_12120	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H2515_12140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H2515_12150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H2515_12160	COG0436	Aminotransferase
H2515_12175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H2515_12180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H2515_12205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H2515_12210	COG0659	secondary active sulfate transmembrane transporter activity
H2515_12215	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H2515_12230	COG2161	toxin-antitoxin pair type II binding
H2515_12240	COG0495	leucyl-tRNA aminoacylation
H2515_12250	COG1466	dna polymerase III delta subunit
H2515_12255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H2515_12260	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H2515_12260	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H2515_12265	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H2515_12270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2515_12275	COG0497	DNA recombination
H2515_12280	COG2205	protein histidine kinase activity
H2515_12290	COG2204	response regulator
H2515_12300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2515_12325	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H2515_12440	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H2515_12445	COG0295	cytidine deaminase activity
H2515_12455	COG1953	Uracil, thiamine, allantoin
H2515_12470	COG0493	'glutamate synthase
H2515_12480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H2515_12485	COG1917	Cupin 2, conserved barrel domain protein
H2515_12485	COG1396	sequence-specific DNA binding
H2515_12495	COG0583	DNA-binding transcription factor activity
H2515_12505	COG0746	molybdenum cofactor guanylyltransferase activity
H2515_12525	COG3608	succinylglutamate desuccinylase aspartoacylase
H2515_12525	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H2515_12550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H2515_12560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H2515_12565	COG0402	S-adenosylhomocysteine deaminase activity
H2515_12580	COG0848	biopolymer transport protein
H2515_12585	COG0811	peptide transport
H2515_12595	COG0242	peptide deformylase activity
H2515_12605	COG0235	Class ii aldolase
H2515_12610	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
H2515_12615	COG1850	ribulose-bisphosphate carboxylase activity
H2515_12620	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H2515_12640	COG0347	Belongs to the P(II) protein family
H2515_12645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2515_12645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H2515_12650	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H2515_12660	COG0045	succinate-CoA ligase (ADP-forming) activity
H2515_12665	COG0538	isocitrate dehydrogenase activity
H2515_12670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H2515_12675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2515_12680	COG1388	LysM domain
H2515_12680	COG0741	lytic transglycosylase activity
H2515_12690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H2515_12695	COG0583	DNA-binding transcription factor activity
H2515_12710	COG2863	cytochrome
H2515_12715	COG1028	Short-chain dehydrogenase reductase Sdr
H2515_12720	COG0723	plastoquinol--plastocyanin reductase activity
H2515_12725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H2515_12745	COG1640	4-alpha-glucanotransferase
H2515_12750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H2515_12760	COG0366	Alpha amylase catalytic
H2515_12780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H2515_12810	COG0717	Belongs to the dCTP deaminase family
H2515_12815	COG0489	protein tyrosine kinase activity
H2515_12825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H2515_12830	COG0484	heat shock protein binding
H2515_12835	COG0443	Heat shock 70 kDa protein
H2515_12840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H2515_12845	COG1420	regulation of RNA biosynthetic process
H2515_12850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H2515_12855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H2515_12860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2515_12860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2515_12865	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H2515_12870	COG0114	fumarate hydratase activity
H2515_12895	COG0297	glycogen (starch) synthase activity
H2515_12900	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H2515_12910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H2515_12935	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H2515_12940	COG0633	Ferredoxin
H2515_12940	COG0543	2 iron, 2 sulfur cluster binding
H2515_12945	COG1151	hydroxylamine reductase activity
H2515_13050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_13105	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H2515_13110	COG1534	Rna-binding protein
H2515_13115	COG2967	ApaG domain
H2515_13120	COG2226	methyltransferase
H2515_13140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H2515_13155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H2515_13160	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H2515_13165	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H2515_13180	COG2177	Part of the ABC transporter FtsEX involved in
H2515_13185	COG2884	Cell division ATP-binding protein ftsE
H2515_13190	COG0552	protein localization to endoplasmic reticulum
H2515_13195	COG0742	ribosomal rna small subunit methyltransferase
H2515_13200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H2515_13205	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2515_13210	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H2515_13215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H2515_13220	COG2890	protein-(glutamine-N5) methyltransferase activity
H2515_13225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H2515_13230	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H2515_13245	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H2515_13255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2515_13315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2515_13445	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_13465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2515_13475	COG3657	addiction module killer protein
H2515_13480	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_13500	COG5001	Diguanylate cyclase
H2515_13500	COG3300	MHYT domain
H2515_13555	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H2515_13570	COG0006	proline dipeptidase activity
H2515_13585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2515_13590	COG0305	Participates in initiation and elongation during chromosome replication
H2515_13595	COG0359	binds to the 23S rRNA
H2515_13610	COG0360	Binds together with S18 to 16S ribosomal RNA
H2515_13615	COG1472	Belongs to the glycosyl hydrolase 3 family
H2515_13620	COG0531	amino acid
H2515_13630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H2515_13655	COG0363	glucosamine-6-phosphate deaminase activity
H2515_13670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H2515_13675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H2515_13685	COG1449	Belongs to the glycosyl hydrolase 57 family
H2515_13690	COG1940	carbohydrate kinase activity
H2515_13695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H2515_13700	COG2733	membrane
H2515_13725	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H2515_13730	COG0629	single-stranded DNA binding
H2515_13745	COG3118	belongs to the thioredoxin family
H2515_13750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2515_13765	COG0335	large ribosomal subunit rRNA binding
H2515_13770	COG0336	Belongs to the RNA methyltransferase TrmD family
H2515_13780	COG0228	four-way junction DNA binding
H2515_13785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H2515_13835	COG1872	DUF167
H2515_13840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H2515_13850	COG1566	PFAM secretion protein HlyD family protein
H2515_13855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H2515_13860	COG1309	transcriptional regulator
H2515_13880	COG0543	2 iron, 2 sulfur cluster binding
H2515_13880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2515_13885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2515_13890	COG0390	transport system, permease component
H2515_13895	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H2515_13900	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H2515_13910	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H2515_13915	COG2226	methyltransferase
H2515_13920	COG0596	Alpha beta hydrolase
H2515_13925	COG0156	8-amino-7-oxononanoate synthase activity
H2515_13930	COG1040	competence protein
H2515_13935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H2515_13940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H2515_13945	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H2515_13950	COG1560	Kdo2-lipid A biosynthetic process
H2515_13955	COG1519	Transferase
H2515_13985	COG4636	protein conserved in cyanobacteria
H2515_13990	COG0438	transferase activity, transferring glycosyl groups
H2515_13995	COG0726	polysaccharide deacetylase
H2515_14000	COG0463	Glycosyl transferase, family 2
H2515_14005	COG0494	nUDIX hydrolase
H2515_14010	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H2515_14015	COG0653	protein targeting
H2515_14025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H2515_14030	COG0625	glutathione transferase activity
H2515_14035	COG1022	Amp-dependent synthetase and ligase
H2515_14040	COG0617	tRNA 3'-terminal CCA addition
H2515_14055	COG2001	Belongs to the MraZ family
H2515_14060	COG0275	rRNA processing
H2515_14075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H2515_14080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H2515_14085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H2515_14090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H2515_14095	COG0772	Belongs to the SEDS family
H2515_14100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H2515_14105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2515_14110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H2515_14115	COG1181	Belongs to the D-alanine--D-alanine ligase family
H2515_14130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H2515_14145	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H2515_14150	COG0511	ligase activity, forming carbon-carbon bonds
H2515_14155	COG0439	Biotin carboxylase
H2515_14160	COG2264	protein methyltransferase activity
H2515_14170	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H2515_14175	COG0741	lytic transglycosylase activity
H2515_14175	COG0739	heme binding
H2515_14175	COG1196	nuclear chromosome segregation
H2515_14180	COG2969	positive regulation of protein catabolic process
H2515_14220	COG0475	glutathione-regulated potassium exporter activity
H2515_14225	COG1028	Short-chain dehydrogenase reductase Sdr
H2515_14240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H2515_14285	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H2515_14290	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H2515_14295	COG0237	dephospho-CoA kinase activity
H2515_14315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2515_14320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H2515_14325	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H2515_14330	COG1047	Peptidyl-prolyl cis-trans
H2515_14335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H2515_14345	COG0625	glutathione transferase activity
H2515_14350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H2515_14360	COG0708	Exodeoxyribonuclease III
H2515_14370	COG0477	Major facilitator Superfamily
H2515_14375	COG3264	Mechanosensitive ion channel
H2515_14375	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H2515_14380	COG0018	arginyl-trna synthetase
H2515_14395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H2515_14405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H2515_14410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H2515_14415	COG1131	(ABC) transporter
H2515_14430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H2515_14435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H2515_14440	COG1127	ABC transporter
H2515_14445	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H2515_14450	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H2515_14455	COG2062	phosphohistidine phosphatase, SixA
H2515_14460	COG2204	response regulator
H2515_14470	COG2205	protein histidine kinase activity
H2515_14480	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H2515_14495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2515_14510	COG1660	Displays ATPase and GTPase activities
H2515_14515	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H2515_14520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2515_14520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2515_14520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2515_14550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H2515_14575	COG3178	'Phosphotransferase
H2515_14580	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H2515_14585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2515_14590	COG0842	Transport permease protein
H2515_14595	COG0271	Belongs to the BolA IbaG family
H2515_14600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H2515_14605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H2515_14610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H2515_14615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H2515_14620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H2515_14625	COG0131	Imidazoleglycerol-phosphate dehydratase
H2515_14630	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H2515_14635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H2515_14640	COG0107	imidazoleglycerol-phosphate synthase activity
H2515_14645	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H2515_14645	COG0140	phosphoribosyl-ATP diphosphatase activity
H2515_14650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2515_14655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H2515_14660	COG0805	protein transport
H2515_14665	COG0438	transferase activity, transferring glycosyl groups
H2515_14675	COG1278	Cold shock
H2515_14690	COG3158	transport of potassium into the cell
H2515_14710	COG0540	Belongs to the ATCase OTCase family
H2515_14715	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H2515_14720	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H2515_14725	COG1678	Uncharacterized ACR, COG1678
H2515_14730	COG0189	ligase activity
H2515_14745	COG0316	Belongs to the HesB IscA family
H2515_14750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2515_14755	COG0022	dehydrogenase e1 component
H2515_14755	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2515_14760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H2515_14775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H2515_14780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H2515_14785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H2515_14795	COG0778	Nitroreductase
H2515_14800	COG2081	HI0933 family
H2515_14835	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2515_14840	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H2515_14855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2515_14865	COG1611	Belongs to the LOG family
H2515_14875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2515_14880	COG1555	photosystem II stabilization
H2515_14885	COG0210	DNA helicase
H2515_14910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2515_14950	COG0583	DNA-binding transcription factor activity
H2515_14960	COG0038	chloride channel
H2515_14970	COG2814	Major facilitator Superfamily
H2515_14985	COG0076	glutamate decarboxylase activity
H2515_14990	COG0531	amino acid
H2515_15060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2515_15070	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H2515_15090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H2515_15105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2515_15190	COG0038	chloride channel
H2515_15230	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2515_15250	COG3158	transport of potassium into the cell
H2515_15255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2515_15275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2515_15295	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H2515_15300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H2515_15310	COG0651	ATP synthesis coupled electron transport
H2515_15315	COG3260	NADH ubiquinone oxidoreductase 20
H2515_15320	COG3261	NADH dehydrogenase
H2515_15320	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H2515_15325	COG0651	ATP synthesis coupled electron transport
H2515_15335	COG0650	Formate hydrogenlyase subunit 4
H2515_15365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H2515_15380	COG0148	phosphopyruvate hydratase activity
H2515_15385	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H2515_15420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H2515_15435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H2515_15440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H2515_15445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H2515_15450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H2515_15460	COG0356	it plays a direct role in the translocation of protons across the membrane
H2515_15470	COG1475	DNA binding
H2515_15480	COG0357	Ribosomal RNA small subunit methyltransferase G
H2515_15485	COG0445	tRNA wobble uridine modification
H2515_15500	COG0521	Mo-molybdopterin cofactor biosynthetic process
H2515_15530	COG0247	lactate metabolic process
H2515_15535	COG0277	FAD linked oxidase domain protein
H2515_15540	COG0277	FAD linked oxidase domain protein
H2515_15610	COG1216	Glycosyl transferase, family 2
H2515_15650	COG1088	dTDP-glucose 4,6-dehydratase activity
H2515_15655	COG1091	dTDP-4-dehydrorhamnose reductase activity
H2515_15665	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H2515_15670	COG0477	Major facilitator Superfamily
H2515_15680	COG0113	porphobilinogen synthase activity
H2515_15690	COG0181	hydroxymethylbilane synthase activity
H2515_15700	COG0537	adenosine 5'-monophosphoramidase activity
H2515_15705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H2515_15710	COG0352	thiamine-phosphate diphosphorylase activity
H2515_15715	COG0351	phosphomethylpyrimidine kinase
H2515_15735	COG2857	Cytochrome c1
H2515_15740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H2515_15745	COG0723	plastoquinol--plastocyanin reductase activity
H2515_15750	COG1028	Short-chain dehydrogenase reductase Sdr
H2515_15765	COG3154	lipid carrier protein
H2515_15770	COG0826	peptidase U32
H2515_15775	COG0826	peptidase U32
H2515_15795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H2515_15795	COG1328	CTP reductase activity