locus-tag	class	description
AFE_0001	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
AFE_0002	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
AFE_0003	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AFE_0011	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
AFE_0012	ENOG4107QMS	site-determining protein
AFE_0013	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
AFE_0014	ENOG4108Z4U	Ferredoxin
AFE_0015	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
AFE_0016	ENOG4108RPN	Protein smg homolog
AFE_0017	ENOG4105C79	DNA protecting protein DprA
AFE_0019	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
AFE_0020	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
AFE_0021	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
AFE_0023	ENOG4105ES5	Histidine kinase
AFE_0024	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
AFE_0026	ENOG4105BZU	Histidine kinase
AFE_0027	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
AFE_0031	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
AFE_0032	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
AFE_0033	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
AFE_0035	ENOG4105VG0	50S ribosomal protein l34
AFE_0036	ENOG4105C5H	ABC transporter
AFE_0038	ENOG4105CW7	secretion protein, HlyD family
AFE_0049	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
AFE_0054	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
AFE_0056	ENOG4105C9M	aspartyl-trna synthetase
AFE_0057	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
AFE_0059	ENOG4105CDY	transcriptional regulatory protein
AFE_0060	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
AFE_0061	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
AFE_0062	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
AFE_0063	ENOG4107YD3	Thioesterase
AFE_0064	ENOG4105E02	MotA TolQ exbB proton channel
AFE_0065	ENOG4105M8F	Biopolymer transport protein exbD tolR
AFE_0067	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
AFE_0068	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
AFE_0069	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
AFE_0071	ENOG4105KCK	Peptidoglycan-associated lipoprotein
AFE_0073	ENOG4105D3Q	Sugar transferase
AFE_0076	ENOG4108MX3	Polysaccharide Biosynthesis Protein
AFE_0077	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
AFE_0079	ENOG4107XB0	Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
AFE_0081	ENOG4108TJN	glycosyl transferase group 1
AFE_0082	ENOG4108KBE	Glycosyl transferase, family 2
AFE_0092	ENOG4107R3N	Filamentation induced by cAMP protein fic
AFE_0101	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
AFE_0105	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
AFE_0106	ENOG4105E0F	Histidine kinase
AFE_0107	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
AFE_0109	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
AFE_0122	ENOG4105ED9	Protein of unknown function (DUF455)
AFE_0123	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AFE_0125	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
AFE_0126	ENOG4107ZVW	dihydroneopterin aldolase
AFE_0127	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
AFE_0129	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
AFE_0134	ENOG4105D4P	Coproporphyrinogen iii oxidase
AFE_0135	ENOG4105DZ2	Transcriptional regulator
AFE_0138	ENOG4105XA0	heptosyltransferase ii
AFE_0140	ENOG4105CQB	FAD linked oxidase domain protein
AFE_0141	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
AFE_0142	ENOG41082RQ	UPF0102 protein
AFE_0143	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
AFE_0144	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
AFE_0150	ENOG4105IH7	synthase
AFE_0154	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
AFE_0156	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
AFE_0157	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
AFE_0158	ENOG4105DHJ	ABC, transporter
AFE_0159	ENOG4105CY3	ABC transporter, permease
AFE_0160	ENOG4107PE3	Mammalian cell entry related domain protein
AFE_0163	ENOG4105DA5	(ABC) transporter
AFE_0164	ENOG41082I2	s4 domain protein
AFE_0165	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
AFE_0167	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
AFE_0170	ENOG4105C75	arginyL-tRNA synthetase
AFE_0171	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
AFE_0172	ENOG4105DND	Transcriptional regulator
AFE_0173	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
AFE_0174	ENOG4105CGK	Exodeoxyribonuclease III
AFE_0176	ENOG4105D6S	protein involved in catabolism of external DNA
AFE_0177	ENOG4108U78	Glutathione S-transferase
AFE_0178	ENOG4105CGK	Exodeoxyribonuclease III
AFE_0179	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
AFE_0180	ENOG4108YZY	peptidylprolyl cis-trans isomerase
AFE_0181	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
AFE_0182	ENOG4105E2X	shikimate dehydrogenase
AFE_0183	ENOG4107QHF	type ii secretion system protein e
AFE_0184	ENOG4107TUY	Histidine kinase
AFE_0185	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
AFE_0187	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
AFE_0188	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
AFE_0189	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AFE_0191	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
AFE_0192	ENOG4105E4C	Lytic transglycosylase catalytic
AFE_0194	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
AFE_0195	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
AFE_0196	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
AFE_0197	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
AFE_0200	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
AFE_0201	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
AFE_0202	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
AFE_0203	ENOG4105CPF	Cell wall formation (By similarity)
AFE_0204	ENOG4105D4A	Cell wall formation (By similarity)
AFE_0205	ENOG4105DFU	Cell wall formation (By similarity)
AFE_0206	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
AFE_0207	ENOG4105CNI	cell division protein FtsW
AFE_0208	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
AFE_0209	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
AFE_0210	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
AFE_0211	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
AFE_0212	ENOG4105CJN	penicillin-binding protein
AFE_0214	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
AFE_0215	ENOG4108V6E	Cell division protein mraZ
AFE_0218	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
AFE_0220	ENOG4108IQE	Amp-dependent synthetase and ligase
AFE_0221	ENOG4107MKT	Stringent starvation protein a
AFE_0223	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
AFE_0225	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
AFE_0226	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
AFE_0227	ENOG4105M6F	mutator MutT protein
AFE_0228	ENOG4105CKK	Glycosyl transferase, family 2
AFE_0230	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
AFE_0231	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
AFE_0235	ENOG4105D16	lipopolysaccharide heptosyltransferase i
AFE_0237	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
AFE_0238	ENOG4105D1S	lipid A biosynthesis
AFE_0239	ENOG4105C87	Aminotransferase class I and II
AFE_0240	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
AFE_0241	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
AFE_0242	ENOG4105MJ2	Competence protein
AFE_0243	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
AFE_0244	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
AFE_0245	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
AFE_0246	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
AFE_0247	ENOG4105D0M	Protease HtpX homolog
AFE_0248	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
AFE_0249	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
AFE_0250	ENOG4105C4B	ABC transporter, permease
AFE_0251	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
AFE_0252	ENOG4108EX3	reductase
AFE_0255	ENOG4105R8C	Transcriptional regulator
AFE_0256	ENOG4105CAS	nag kinase
AFE_0257	ENOG4105CW7	secretion protein, HlyD family
AFE_0259	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
AFE_0260	ENOG4105VZ9	UPF0235 protein
AFE_0261	ENOG4108VIA	integral membrane protein
AFE_0262	ENOG4105II7	pyrroline-5-carboxylate reductase
AFE_0263	ENOG4105DFA	alanine racemase domain protein
AFE_0264	ENOG4105CZX	twitching motility protein
AFE_0265	ENOG4105CZX	twitching motility protein
AFE_0270	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
AFE_0271	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
AFE_0272	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
AFE_0273	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
AFE_0276	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
AFE_0277	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
AFE_0278	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
AFE_0279	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
AFE_0280	ENOG4108Z1B	Cyclase dehydrase
AFE_0281	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
AFE_0282	ENOG41090R7	Ferric uptake
AFE_0283	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFE_0284	ENOG4105K46	50S ribosomal protein l27
AFE_0285	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
AFE_0286	ENOG4105CHH	sulfate transporter
AFE_0287	ENOG4107B2H	carbonic anhydrase
AFE_0288	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
AFE_0289	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
AFE_0292	ENOG4105DWV	Homoserine O-trans-acetylase
AFE_0293	ENOG4105DWV	Homoserine O-trans-acetylase
AFE_0295	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
AFE_0296	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
AFE_0297	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
AFE_0299	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
AFE_0300	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
AFE_0301	ENOG4107YIM	Involved in the transcription termination process (By similarity)
AFE_0305	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
AFE_0311	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
AFE_0314	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
AFE_0315	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
AFE_0316	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
AFE_0317	ENOG4108VZM	50s ribosomal protein L10
AFE_0318	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
AFE_0320	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AFE_0321	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AFE_0322	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
AFE_0323	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
AFE_0324	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
AFE_0325	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
AFE_0326	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
AFE_0327	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
AFE_0328	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
AFE_0329	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
AFE_0330	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFE_0331	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
AFE_0332	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
AFE_0333	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
AFE_0334	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
AFE_0336	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
AFE_0337	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
AFE_0338	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
AFE_0339	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFE_0340	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
AFE_0341	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
AFE_0342	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
AFE_0343	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
AFE_0344	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
AFE_0345	ENOG41084RK	50S ribosomal protein L30
AFE_0346	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
AFE_0347	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
AFE_0348	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
AFE_0349	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
AFE_0350	ENOG41067V7	50S ribosomal protein L36
AFE_0351	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFE_0352	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
AFE_0353	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
AFE_0354	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AFE_0355	ENOG4108ZT0	50S ribosomal protein l17
AFE_0356	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
AFE_0358	ENOG4105W5Q	DNA repair protein (RadC
AFE_0360	ENOG410841Q	phosphoesterase PA-phosphatase related protein
AFE_0364	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
AFE_0365	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
AFE_0366	ENOG4105DC8	reductase
AFE_0367	ENOG4105EHV	domain protein
AFE_0368	ENOG4105EAC	phosphoserine phosphatase
AFE_0369	ENOG4108JA2	transcriptioN-repair coupling factor
AFE_0370	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
AFE_0371	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
AFE_0372	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
AFE_0375	ENOG4105C3M	thioredoxin reductase
AFE_0377	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
AFE_0379	ENOG4105D1H	recombination factor protein RarA
AFE_0380	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
AFE_0382	ENOG4108PXI	ErfK YbiS YcfS YnhG
AFE_0389	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
AFE_0390	ENOG4105CHV	Transcription elongation factor NusA
AFE_0391	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
AFE_0392	ENOG41082KD	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
AFE_0393	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
AFE_0394	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
AFE_0395	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
AFE_0397	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
AFE_0399	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
AFE_0400	ENOG4107RZZ	dna polymerase iii epsilon subunit
AFE_0404	ENOG4105CDH	Citrulline--aspartate ligase
AFE_0405	ENOG4105DBV	ornithine carbamoyltransferase
AFE_0406	ENOG4105C8Y	Acetylornithine aminotransferase
AFE_0407	ENOG4105CFH	Aspartokinase
AFE_0412	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
AFE_0416	ENOG4105X0D	Fimbrial protein
AFE_0419	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
AFE_0420	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
AFE_0421	ENOG4105E9H	Lytic Murein transglycosylase
AFE_0422	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
AFE_0424	ENOG4108HMX	isocitrate dehydrogenase (NADP)
AFE_0425	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
AFE_0427	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
AFE_0428	ENOG4105C4K	Nad synthetase
AFE_0429	ENOG4108YZA	Nitrogen regulatory protein pii
AFE_0430	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFE_0431	ENOG4105C34	Pseudouridine synthase
AFE_0432	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
AFE_0433	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
AFE_0434	ENOG4107RAT	Ribulose bisphosphate carboxylase large chain, catalytic domain
AFE_0435	ENOG41080FP	Hydrolase
AFE_0436	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
AFE_0438	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
AFE_0439	ENOG4107QTZ	amino acid
AFE_0441	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
AFE_0445	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
AFE_0447	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
AFE_0449	ENOG4107WP9	Histidine kinase
AFE_0450	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
AFE_0451	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
AFE_0452	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
AFE_0453	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
AFE_0454	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
AFE_0457	ENOG4105DJF	DNA polymerase III, delta' subunit
AFE_0459	ENOG4105C8T	Leucyl-tRNA synthetase
AFE_0460	ENOG4105CS1	NAD(P)H quinone oxidoreductase
AFE_0461	ENOG4108YYC	ycei family
AFE_0463	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
AFE_0466	ENOG4105C5F	glutamine synthetase
AFE_0468	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
AFE_0469	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
AFE_0470	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AFE_0472	ENOG4105CHM	Aminotransferase
AFE_0473	ENOG4105D6E	homoserine dehydrogenase
AFE_0476	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
AFE_0477	ENOG4105XMH	SpoVT AbrB domain protein
AFE_0480	ENOG4105CRK	lysyL-tRNA synthetase
AFE_0481	ENOG4105D60	lipoprotein releasing system transmembrane protein
AFE_0483	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
AFE_0484	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
AFE_0485	ENOG4105E02	MotA TolQ exbB proton channel
AFE_0486	ENOG4109015	Biopolymer transport protein exbD tolR
AFE_0489	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
AFE_0490	ENOG4105W49	UPF0434 protein
AFE_0491	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
AFE_0496	ENOG4108Z0R	Transferase
AFE_0502	ENOG4105KAC	Antibiotic biosynthesis monooxygenase
AFE_0508	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFE_0509	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFE_0518	ENOG4108RG0	uracil-dna glycosylase
AFE_0519	ENOG4105CNG	UPF0061 protein
AFE_0520	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
AFE_0521	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
AFE_0522	ENOG4107TF3	peptidylprolyl cis-trans isomerase
AFE_0523	ENOG4107S0N	DJ-1 family
AFE_0524	ENOG4105CN1	protease
AFE_0526	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
AFE_0529	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
AFE_0532	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
AFE_0534	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
AFE_0535	ENOG4105SYT	Methylenetetrahydrofolate reductase
AFE_0539	ENOG4107RIQ	Sulfate adenylate transferase
AFE_0540	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
AFE_0542	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
AFE_0543	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
AFE_0545	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
AFE_0547	ENOG4105CM2	brancheD-chain amino acid aminotransferase
AFE_0548	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
AFE_0555	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
AFE_0556	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
AFE_0557	ENOG4105DTN	riboflavin biosynthesis protein ribF
AFE_0559	ENOG4105CJR	Integral membrane protein (MviN
AFE_0562	ENOG4105DSJ	YicC domain protein
AFE_0563	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
AFE_0564	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
AFE_0565	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
AFE_0566	ENOG4105KME	endoribonuclease L-psp
AFE_0568	ENOG4105CB5	ATP-dependent DNA helicase recG
AFE_0570	ENOG4105C1Q	protoporphyrinogen oxidase
AFE_0571	ENOG4105C02	permease
AFE_0572	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
AFE_0573	ENOG4105NBF	ammecr1 domain protein
AFE_0575	ENOG4105DFG	type I secretion outer membrane protein
AFE_0576	ENOG4105CRQ	synthase (Component I)
AFE_0589	ENOG4105C1J	atp-dependent rna helicase
AFE_0590	ENOG4105VEQ	Cold shock protein
AFE_0591	ENOG4105C25	Primosomal protein n'
AFE_0592	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
AFE_0594	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
AFE_0596	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
AFE_0597	ENOG4105C9A	Phoh family
AFE_0598	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
AFE_0599	ENOG4108JU5	Magnesium and cobalt efflux protein
AFE_0600	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
AFE_0601	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
AFE_0603	ENOG4105DIK	(ABC) transporter
AFE_0605	ENOG4105FAV	ABC, transporter
AFE_0615	ENOG4107T8Q	Glycosyl transferase (Group 1
AFE_0616	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
AFE_0617	ENOG4105BZ1	(ABC) transporter
AFE_0618	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
AFE_0621	ENOG4105CVJ	phosphoglycerate mutase
AFE_0623	ENOG4105F2W	methyltransferase
AFE_0624	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AFE_0626	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AFE_0628	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
AFE_0629	ENOG4105E66	phosphoriboisomerase A
AFE_0631	ENOG4105E2S	oxidase) subunit II
AFE_0632	ENOG4105BZ9	Cytochrome C oxidase, subunit I
AFE_0633	ENOG4105CCU	oxidase (Subunit III)
AFE_0635	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
AFE_0636	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
AFE_0637	ENOG4107RDB	Major Facilitator
AFE_0638	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
AFE_0639	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
AFE_0640	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
AFE_0642	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
AFE_0643	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
AFE_0645	ENOG4105DFU	Cell wall formation (By similarity)
AFE_0646	ENOG4105DHJ	ABC, transporter
AFE_0647	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
AFE_0648	ENOG4105CY3	ABC transporter, permease
AFE_0652	ENOG4105D06	uba thif-type nad fad binding protein
AFE_0655	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
AFE_0657	ENOG4105K63	Thioredoxin
AFE_0658	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
AFE_0659	ENOG4105VFB	Binds the 23S rRNA (By similarity)
AFE_0660	ENOG4105C6K	Malic enzyme
AFE_0661	ENOG4105IPI	Membrane
AFE_0662	ENOG4105C01	Dihydroxy-acid dehydratase
AFE_0664	ENOG4107QZM	n-acetylglutamate synthase
AFE_0665	ENOG4105M85	Bola protein
AFE_0666	ENOG4105K9H	YciI-like protein
AFE_0667	ENOG4107835	probably involved in intracellular septation (By similarity)
AFE_0669	ENOG4105ECY	inositol monophosphatase
AFE_0670	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
AFE_0672	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
AFE_0673	ENOG4105C3J	Cysteine desulfurase
AFE_0674	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
AFE_0675	ENOG4108Z4V	iron-sulfur cluster assembly
AFE_0676	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
AFE_0677	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
AFE_0678	ENOG4108ZIT	Ferredoxin, 2FE-2S
AFE_0679	ENOG4105WVQ	Fe-S assembly protein IscX
AFE_0680	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
AFE_0681	ENOG4105D78	K07001 NTE family protein
AFE_0686	ENOG4107QTH	restriction modification system DNA specificity domain
AFE_0690	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
AFE_0693	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
AFE_0696	ENOG4108QBQ	Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione (By similarity)
AFE_0697	ENOG4107QPD	alcohol dehydrogenase
AFE_0698	ENOG4105C4W	S-formylglutathione hydrolase
AFE_0699	ENOG4107R11	Transcriptional regulator
AFE_0702	ENOG4105DPX	Hydrogenase, large subunit
AFE_0710	ENOG41083MR	nifu domain-containing protein
AFE_0712	ENOG4105C8H	hydrogenase maturation protein Hypf
AFE_0713	ENOG41082MF	Hydrogenase assembly chaperone hypC hupF
AFE_0714	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
AFE_0715	ENOG4105CQS	hydrogenase expression formation protein HypD
AFE_0716	ENOG4105C45	hydrogenase expression formation protein (HypE)
AFE_0717	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
AFE_0720	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
AFE_0722	ENOG4105C7B	Threonine dehydratase
AFE_0727	ENOG4108Z20	Acyl-transferase
AFE_0728	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
AFE_0729	ENOG4105BZ8	glutamate synthase
AFE_0730	ENOG4105CBC	glutamate synthase
AFE_0731	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
AFE_0732	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
AFE_0733	ENOG4105D49	3-dehydroquinate synthase
AFE_0734	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
AFE_0735	ENOG4105E4G	Type IV pilus
AFE_0741	ENOG4108Z6B	deaminase
AFE_0744	ENOG4105C98	muts2 protein
AFE_0745	ENOG4105C7K	acetolactate synthase
AFE_0746	ENOG4108ZP8	Acetolactate synthase small subunit
AFE_0747	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
AFE_0748	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
AFE_0750	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
AFE_0751	ENOG4107YZX	Universal stress protein
AFE_0752	ENOG4107YRI	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
AFE_0753	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
AFE_0757	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AFE_0758	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
AFE_0764	ENOG4105HF0	Membrane
AFE_0768	ENOG4105E02	MotA TolQ exbB proton channel
AFE_0769	ENOG4105M8F	Biopolymer transport protein exbD tolR
AFE_0772	ENOG4107QUY	Guanine deaminase
AFE_0773	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
AFE_0780	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
AFE_0784	ENOG41084WP	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
AFE_0785	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
AFE_0793	ENOG4105C2D	reductase
AFE_0809	ENOG4105C7W	Xanthine dehydrogenase
AFE_0813	ENOG4107RDB	Major Facilitator
AFE_0814	ENOG4105CMQ	Chloride channel
AFE_0817	ENOG4105DUM	transcriptional regulator, lysR family
AFE_0827	ENOG4105CB5	ATP-dependent DNA helicase recG
AFE_0833	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFE_0834	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFE_0840	ENOG4105ESI	atpase involved in dna repair
AFE_0841	ENOG4105DZR	Type I site-specific deoxyribonuclease
AFE_0845	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
AFE_0846	ENOG4105DQ4	alcohol dehydrogenase
AFE_0847	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
AFE_0848	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
AFE_0849	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
AFE_0850	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
AFE_0851	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
AFE_0853	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
AFE_0857	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
AFE_0858	ENOG4105K78	MarR family Transcriptional regulator
AFE_0861	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
AFE_0862	ENOG4105CW7	secretion protein, HlyD family
AFE_0864	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
AFE_0866	ENOG4107F9Y	LysR family transcriptional regulator
AFE_0869	ENOG41084HI	prevent-host-death family
AFE_0872	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
AFE_0878	ENOG4105VRR	gCN5-related N-acetyltransferase
AFE_0879	ENOG4105ETT	transcriptional Regulator, LysR family
AFE_0883	ENOG4105CHR	reductase
AFE_0888	ENOG41082CH	UPF0145 protein
AFE_0890	ENOG4105K4U	addiction module toxin, RelE StbE family
AFE_0892	ENOG4105DR4	Methyltransferase
AFE_0893	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
AFE_0894	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AFE_0895	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
AFE_0897	ENOG4105CQC	Prephenate dehydratase
AFE_0898	ENOG4105CIH	Imidazole acetol-phosphate transaminase
AFE_0899	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
AFE_0901	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
AFE_0902	ENOG4105CAT	Cytidine monophosphate kinase
AFE_0903	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
AFE_0905	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
AFE_0906	ENOG4105CFV	Tetratricopeptide repeat protein
AFE_0907	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
AFE_0908	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
AFE_0909	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
AFE_0910	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
AFE_0911	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
AFE_0912	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
AFE_0918	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
AFE_0923	ENOG41075W9	High frequency lysogenization protein HflD homolog
AFE_0924	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
AFE_0925	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
AFE_0926	ENOG4105PW4	Sugar fermentation stimulation protein homolog
AFE_0927	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
AFE_0928	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
AFE_0929	ENOG4108ZAI	phosphatidylglycerophosphatase a
AFE_0930	ENOG4105CEV	competence damage-inducible protein
AFE_0932	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
AFE_0933	ENOG4105Y3E	Modulates RecA activity (By similarity)
AFE_0934	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
AFE_0941	ENOG4105E4C	Lytic transglycosylase catalytic
AFE_0942	ENOG4105C0D	helicase
AFE_0943	ENOG4106ECQ	phosphomannomutase
AFE_0945	ENOG4105C5H	ABC transporter
AFE_0948	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
AFE_0950	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
AFE_0951	ENOG4107RGH	Aldehyde dehydrogenase
AFE_0954	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
AFE_0955	ENOG4105C4M	(Ubiquinol oxidase) subunit I
AFE_0957	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
AFE_0958	ENOG4107QN2	dihydrolipoyl dehydrogenase
AFE_0962	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
AFE_0964	ENOG4105M08	Membrane
AFE_0973	ENOG4105ERU	peptidase
AFE_0975	ENOG4105M00	molybdopterin converting factor, subunit 1
AFE_0976	ENOG4108ZAF	Molybdopterin
AFE_0977	ENOG4108VPT	UPF0234 protein
AFE_0979	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
AFE_0980	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
AFE_0981	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFE_0982	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFE_0983	ENOG4105BZ1	(ABC) transporter
AFE_0984	ENOG4108Z4U	Ferredoxin
AFE_0985	ENOG4105D3R	alkyl hydroperoxide reductase
AFE_0987	ENOG4105DB7	PHP domain protein
AFE_0988	ENOG4105IPI	Membrane
AFE_0991	ENOG4105C2N	RNA methyltransferase TrmH family group 3
AFE_0992	ENOG4105F8V	Hydrolase, tatD family
AFE_0993	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
AFE_0995	ENOG4108KU3	Integrase
AFE_0998	ENOG4105M7P	phage repressor
AFE_1007	ENOG4105E4C	Lytic transglycosylase catalytic
AFE_1016	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
AFE_1024	ENOG4108Z4T	Peptidase M50
AFE_1047	ENOG4105C7H	Helicase, RecD TraA family
AFE_1057	ENOG4107RDJ	Sulfotransferase
AFE_1058	ENOG4105D7V	transposase
AFE_1070	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
AFE_1073	ENOG4105WXW	Antirepressor
AFE_1087	ENOG4107QHF	type ii secretion system protein e
AFE_1098	ENOG4106A2Z	transcriptional regulator antitoxin, MazE
AFE_1114	ENOG4105D0M	Protease HtpX homolog
AFE_1115	ENOG4108R1E	Serine threonine protein phosphatase 1
AFE_1130	ENOG4105CNU	cell division protein FtsK
AFE_1137	ENOG4105C4R	Atp-dependent dna helicase
AFE_1145	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFE_1199	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
AFE_1211	ENOG4107RDJ	Sulfotransferase
AFE_1215	ENOG4105D7V	transposase
AFE_1230	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AFE_1241	ENOG4105K70	DNA-binding protein
AFE_1260	ENOG4108UUM	single-stranded DNA-binding protein
AFE_1295	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
AFE_1296	ENOG4107R11	Transcriptional regulator
AFE_1326	ENOG4105XB7	anti-repressor protein
AFE_1338	ENOG4106CKV	Pap2 superfamily protein
AFE_1339	ENOG4107V1M	polysaccharide export protein
AFE_1340	ENOG4105D75	Capsular exopolysaccharide family
AFE_1342	ENOG4105CMR	udp-glucose 4-epimerase
AFE_1343	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
AFE_1344	ENOG4108MX3	Polysaccharide Biosynthesis Protein
AFE_1345	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
AFE_1349	ENOG4105CPK	Glycosyl transferase (Group 1
AFE_1351	ENOG4105CPK	Glycosyl transferase (Group 1
AFE_1353	ENOG4105CAQ	asparagine synthetase
AFE_1354	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
AFE_1355	ENOG4107TYR	Glycosyl Transferase
AFE_1357	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
AFE_1366	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
AFE_1370	ENOG4105D3Q	Sugar transferase
AFE_1371	ENOG4105C0D	helicase
AFE_1373	ENOG4105F5W	AtP-binding protein
AFE_1375	ENOG41077G6	
AFE_1378	ENOG4105VU5	Resolvase domain-containing protein
AFE_1388	ENOG4108JJ9	ABC, transporter
AFE_1390	ENOG4108JJ8	(ABC) transporter
AFE_1391	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
AFE_1392	ENOG4108IYU	L-aspartate oxidase
AFE_1394	ENOG4105EMN	RNA polymerase sigma factor
AFE_1396	ENOG4105C0H	protease
AFE_1397	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
AFE_1398	ENOG4105C3F	Signal peptidase i
AFE_1400	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
AFE_1401	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
AFE_1402	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
AFE_1403	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
AFE_1404	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
AFE_1405	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
AFE_1406	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
AFE_1407	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
AFE_1408	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
AFE_1412	ENOG4108R8Z	these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
AFE_1427	ENOG4105BZF	Glycosyl transferase (Group 1
AFE_1429	ENOG41090Y2	cytochrome C
AFE_1430	ENOG4105PGM	cation diffusion facilitator family transporter
AFE_1433	ENOG4105C1J	atp-dependent rna helicase
AFE_1434	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AFE_1435	ENOG4105BZU	Histidine kinase
AFE_1436	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
AFE_1437	ENOG4105C8U	phosphate abc transporter
AFE_1438	ENOG4105E2Z	phosphate ABC transporter (Permease
AFE_1439	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
AFE_1440	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
AFE_1441	ENOG4105C9X	ppx gppa phosphatase
AFE_1444	ENOG4105CE9	30S ribosomal protein S2
AFE_1445	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
AFE_1446	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
AFE_1447	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
AFE_1448	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
AFE_1449	ENOG4105KNE	Phosphatidate cytidylyltransferase
AFE_1450	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
AFE_1452	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFE_1454	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
AFE_1455	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
AFE_1456	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
AFE_1457	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
AFE_1459	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
AFE_1460	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
AFE_1461	ENOG4105C0B	DNA polymerase III (alpha subunit)
AFE_1462	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
AFE_1464	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
AFE_1465	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AFE_1466	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
AFE_1468	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFE_1469	ENOG4108IAB	Phoh family
AFE_1471	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
AFE_1477	ENOG41090P5	ferredoxin-like protein
AFE_1479	ENOG4105C10	Electron transfer flavoprotein
AFE_1480	ENOG4105BZJ	Electron transfer flavoprotein
AFE_1486	ENOG4105M8F	Biopolymer transport protein exbD tolR
AFE_1489	ENOG4105S10	periplasmic binding protein
AFE_1490	ENOG4105EHG	Permease protein
AFE_1491	ENOG4105E0A	ABC, transporter
AFE_1493	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
AFE_1495	ENOG4108I9K	permease protein
AFE_1498	ENOG41066FR	extracellular solute-binding protein
AFE_1502	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
AFE_1504	ENOG410605C	May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity)
AFE_1506	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
AFE_1507	ENOG4105C3J	Cysteine desulfurase
AFE_1508	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
AFE_1509	ENOG4105QAS	Iron-sulfur cluster assembly accessory protein
AFE_1511	ENOG4105PS4	nifq family
AFE_1513	ENOG4105X87	nitrogen fixation
AFE_1514	ENOG4108VQE	nitrogen fixation protein
AFE_1515	ENOG4108UR2	Nitrogen fixation protein NifX
AFE_1516	ENOG4105DK8	Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN
AFE_1517	ENOG4105D0B	Nitrogenase protein alpha chain
AFE_1519	ENOG4105U82	Ferredoxin
AFE_1520	ENOG4105CY9	nitrogenase molybdenum-iron protein beta chain
AFE_1521	ENOG4105D0B	Nitrogenase protein alpha chain
AFE_1522	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
AFE_1524	ENOG4108K8Z	nad( )--dinitrogen-reductase ADP-d-ribosyltransferase
AFE_1525	ENOG41065RQ	ADP-ribosylation crystallin J1
AFE_1527	ENOG4108JUA	Transcriptional regulator
AFE_1529	ENOG4105CGC	Nitrogenase cofactor biosynthesis protein NifB
AFE_1530	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
AFE_1531	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
AFE_1534	ENOG4108QWQ	LRV FeS4 cluster domain protein
AFE_1535	ENOG4105XV5	nifz family
AFE_1537	ENOG4105C3J	Cysteine desulfurase
AFE_1540	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
AFE_1541	ENOG4108ZIT	Ferredoxin, 2FE-2S
AFE_1544	ENOG4107XWS	modD protein
AFE_1545	ENOG4105F4R	Transcriptional regulator mode
AFE_1546	ENOG4105C26	Dehydrogenase
AFE_1550	ENOG4107UH8	sugar kinase
AFE_1551	ENOG4107STW	synthase
AFE_1552	ENOG4105Q84	sucrose synthase
AFE_1553	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
AFE_1556	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFE_1564	ENOG41078CG	DNA-binding transcriptional regulator
AFE_1566	ENOG4106CVF	DNA replication protein
AFE_1569	ENOG4108UUM	single-stranded DNA-binding protein
AFE_1575	ENOG4108F3G	Type I restriction-modification system, R subunit
AFE_1577	ENOG4105CVR	type I restriction-modification system
AFE_1583	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
AFE_1584	ENOG4105K70	DNA-binding protein
AFE_1603	ENOG4107QWP	ABC-2 type transporter
AFE_1604	ENOG4107QWP	ABC-2 type transporter
AFE_1605	ENOG4105CJ1	ABC, transporter
AFE_1606	ENOG4105CJ1	ABC, transporter
AFE_1610	ENOG4105J1P	transposase, IS3 IS911 family protein
AFE_1614	ENOG4105VT3	DNA binding domain protein, excisionase family
AFE_1631	ENOG4105YES	addiction module antidote protein
AFE_1646	ENOG4105C0H	protease
AFE_1648	ENOG4105MYT	Heat shock protein
AFE_1651	ENOG4106KE4	Dehydrogenase
AFE_1652	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
AFE_1654	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
AFE_1656	ENOG4107TVJ	,Oxidoreductase FAD NAD(P)-binding
AFE_1657	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
AFE_1661	ENOG4105EVH	UPF0753 protein
AFE_1662	ENOG4108TWJ	NADH dehydrogenase subunit 5
AFE_1663	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
AFE_1664	ENOG4105EU8	FAD linked oxidase domain protein
AFE_1665	ENOG4105CQB	FAD linked oxidase domain protein
AFE_1672	ENOG4105EKE	dihydroorotase
AFE_1673	ENOG4105C01	Dihydroxy-acid dehydratase
AFE_1674	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AFE_1675	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
AFE_1676	ENOG4105D2N	Aldolase
AFE_1677	ENOG4105FAE	von Willebrand factor, type A
AFE_1680	ENOG4107QJE	Chromosome Partitioning Protein
AFE_1683	ENOG4105KNY	Microcompartments protein
AFE_1684	ENOG4105KNY	Microcompartments protein
AFE_1685	ENOG4105KNY	Microcompartments protein
AFE_1687	ENOG4105WVM	ethanolamine utilization protein EutN carboxysome structural protein Ccml
AFE_1690	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
AFE_1691	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
AFE_1707	ENOG4105BZU	Histidine kinase
AFE_1712	ENOG4105BZU	Histidine kinase
AFE_1719	ENOG4105FA0	parb-like partition protein
AFE_1720	ENOG4107QJE	Chromosome Partitioning Protein
AFE_1723	ENOG4108FN7	Aldo keto reductase
AFE_1725	ENOG4105BZU	Histidine kinase
AFE_1734	ENOG4105YES	addiction module antidote protein
AFE_1738	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
AFE_1740	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
AFE_1741	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
AFE_1742	ENOG4105C26	Dehydrogenase
AFE_1751	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
AFE_1753	ENOG4105DFH	Transport of potassium into the cell (By similarity)
AFE_1754	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
AFE_1762	ENOG4108VPT	UPF0234 protein
AFE_1763	ENOG4108PQP	glycosyl transferase group 1
AFE_1764	ENOG4108MN8	Membrane
AFE_1770	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
AFE_1771	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
AFE_1774	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
AFE_1775	ENOG4105DJ0	Poly(A) Polymerase
AFE_1777	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
AFE_1778	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
AFE_1782	ENOG4107QTZ	amino acid
AFE_1783	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
AFE_1784	ENOG4105EGS	Mechanosensitive ion channel
AFE_1787	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
AFE_1788	ENOG4108Z4T	Peptidase M50
AFE_1789	ENOG4105C31	Tryptophanyl-tRNA synthetase
AFE_1790	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
AFE_1791	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
AFE_1792	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
AFE_1793	ENOG4105FE9	pseudouridine synthase
AFE_1797	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
AFE_1800	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
AFE_1807	ENOG4105DE4	1-phosphofructokinase
AFE_1808	ENOG4107QYA	phosphate
AFE_1809	ENOG4105C54	Major Facilitator superfamily
AFE_1810	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
AFE_1811	ENOG4105C7S	Dehydrogenase
AFE_1813	ENOG4108JYK	Dehydrogenase
AFE_1815	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
AFE_1819	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
AFE_1820	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
AFE_1823	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
AFE_1825	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
AFE_1826	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
AFE_1828	ENOG4105K4H	Nlp p60 protein
AFE_1833	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AFE_1844	ENOG4108Z4U	Ferredoxin
AFE_1848	ENOG4105D03	DNA-3-methyladenine glycosylase II
AFE_1851	ENOG4105K64	Glycosyl transferase, family 2
AFE_1857	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
AFE_1861	ENOG41090A4	Pterin carbinolamine dehydratase
AFE_1868	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
AFE_1871	ENOG4105C0B	DNA polymerase III (alpha subunit)
AFE_1873	ENOG4105CD8	aminopeptidase N
AFE_1876	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
AFE_1877	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
AFE_1878	ENOG4105BZS	acriflavin resistance protein
AFE_1879	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
AFE_1882	ENOG4108UHJ	MAF-like protein
AFE_1883	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
AFE_1884	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
AFE_1885	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
AFE_1886	ENOG4107QJR	hflk protein
AFE_1887	ENOG4105EPW	hflc protein
AFE_1892	ENOG4105CSR	polyphosphate kinase 2
AFE_1893	ENOG4107QN2	dihydrolipoyl dehydrogenase
AFE_1894	ENOG4105CEV	competence damage-inducible protein
AFE_1895	ENOG4105EQR	Transposase IS116 IS110 IS902
AFE_1896	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
AFE_1897	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
AFE_1900	ENOG4108UKJ	Cdp-alcohol phosphatidyltransferase
AFE_1901	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
AFE_1904	ENOG41082GS	50S ribosomal protein L32
AFE_1905	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
AFE_1906	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
AFE_1907	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
AFE_1908	ENOG4105CHR	reductase
AFE_1909	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
AFE_1910	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
AFE_1913	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
AFE_1914	ENOG4107QRG	dna polymerase iii
AFE_1919	ENOG4107QMP	dna polymerase iii subunits gamma and tau
AFE_1920	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
AFE_1921	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
AFE_1923	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
AFE_1924	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
AFE_1926	ENOG4105K8N	protein family UPF0079, ATPase
AFE_1927	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
AFE_1928	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
AFE_1929	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
AFE_1930	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
AFE_1933	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
AFE_1934	ENOG4105CUT	histidyl-tRNA synthetase
AFE_1937	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
AFE_1940	ENOG4105C8U	phosphate abc transporter
AFE_1945	ENOG4105EJ9	Membrane
AFE_1947	ENOG4108IJF	Heavy metal efflux pump, CzcA
AFE_1951	ENOG4108V1U	phospholipid-binding protein
AFE_1953	ENOG4108Z4U	Ferredoxin
AFE_1956	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
AFE_1958	ENOG4105CFU	surface antigen
AFE_1962	ENOG4105W2Z	cytochrome C, class I
AFE_1967	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
AFE_1969	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
AFE_1970	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
AFE_1972	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
AFE_1973	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
AFE_1974	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
AFE_1975	ENOG4105CTB	Polyprenyl synthetase
AFE_1977	ENOG4105EU0	Major facilitator Superfamily
AFE_1979	ENOG41080RH	Thioredoxin
AFE_1980	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
AFE_1981	ENOG4105DZG	Dehydrogenase
AFE_1986	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
AFE_1987	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
AFE_1989	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
AFE_1990	ENOG4105EW9	transcriptional regulator AsnC family
AFE_2012	ENOG41060GW	
AFE_2014	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
AFE_2024	ENOG4108J5G	6-phosphogluconate dehydrogenase
AFE_2025	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
AFE_2026	ENOG41080HT	Transcriptional regulator, arsr family
AFE_2027	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
AFE_2028	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AFE_2029	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AFE_2031	ENOG4105DHQ	Histidine kinase
AFE_2032	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
AFE_2053	ENOG4108303	d-xylulose 5-phosphate d-fructose 6-phosphate phosphoketolase
AFE_2056	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
AFE_2057	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
AFE_2058	ENOG4105VIE	preprotein translocase, subunit YajC
AFE_2059	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
AFE_2060	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
AFE_2061	ENOG4105C37	(CBS) domain
AFE_2063	ENOG4105C28	cystathionine
AFE_2064	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
AFE_2066	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
AFE_2067	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
AFE_2068	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
AFE_2069	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
AFE_2070	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
AFE_2071	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
AFE_2074	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
AFE_2075	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
AFE_2076	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
AFE_2077	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
AFE_2078	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
AFE_2080	ENOG4105D07	Signal peptide peptidase, SppA
AFE_2083	ENOG41088YS	Glycosyl transferase (Group 1
AFE_2090	ENOG4105D0M	Protease HtpX homolog
AFE_2091	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
AFE_2103	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
AFE_2104	ENOG4105BZS	acriflavin resistance protein
AFE_2110	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
AFE_2111	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
AFE_2112	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
AFE_2115	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
AFE_2119	ENOG410901P	UPF0249 protein
AFE_2123	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
AFE_2125	ENOG4105FE1	phytoene synthase
AFE_2126	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
AFE_2127	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
AFE_2129	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
AFE_2130	ENOG4105VGJ	Virulence-associated protein
AFE_2131	ENOG4105C26	Dehydrogenase
AFE_2132	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
AFE_2136	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
AFE_2139	ENOG4105D48	metallophosphoesterase
AFE_2140	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
AFE_2144	ENOG4105CJN	penicillin-binding protein
AFE_2145	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
AFE_2146	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
AFE_2147	ENOG4105C3G	gtp-binding protein
AFE_2148	ENOG4108JCI	Transcriptional regulator
AFE_2149	ENOG4108JPZ	Monovalent cation H antiporter subunit D
AFE_2150	ENOG4107TDF	Formate hydrogenlyase subunit 4
AFE_2152	ENOG4108JPZ	Monovalent cation H antiporter subunit D
AFE_2153	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFE_2154	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFE_2158	ENOG4105DUM	transcriptional regulator, lysR family
AFE_2159	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
AFE_2160	ENOG4105I7M	spermidine synthase
AFE_2167	ENOG4108JJA	ABC, transporter
AFE_2170	ENOG4107BJW	polysaccharide deacetylase
AFE_2172	ENOG4107S1E	Beta-lactamase
AFE_2173	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
AFE_2175	ENOG4105I08	Pseudouridine synthase
AFE_2176	ENOG4105DWY	Agmatine deiminase
AFE_2177	ENOG4105DB1	molybdopterin oxidoreductase
AFE_2178	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
AFE_2183	ENOG4107YZX	Universal stress protein
AFE_2184	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
AFE_2187	ENOG4105C4R	Atp-dependent dna helicase
AFE_2188	ENOG41082GY	Binds directly to 16S ribosomal RNA (By similarity)
AFE_2189	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
AFE_2190	ENOG4105E0C	molybdate abc transporter
AFE_2193	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
AFE_2194	ENOG4105C9U	ATP-dependent DNA helicase RecQ
AFE_2195	ENOG41087PB	Frataxin-like domain
AFE_2200	ENOG4108M8S	permease YjgP YjgQ family protein
AFE_2201	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
AFE_2204	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
AFE_2205	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
AFE_2206	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
AFE_2210	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
AFE_2211	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
AFE_2214	ENOG4105KAF	membrAne
AFE_2218	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
AFE_2219	ENOG4105EI2	Pseudouridine synthase
AFE_2220	ENOG4107QQB	Ribonuclease E
AFE_2221	ENOG4105C8N	cysteinyl-tRNA synthetase
AFE_2222	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
AFE_2223	ENOG4108JQC	penicillin-binding protein 1A
AFE_2225	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
AFE_2228	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
AFE_2229	ENOG4105C08	Histidine kinase
AFE_2232	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
AFE_2233	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
AFE_2234	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
AFE_2238	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
AFE_2240	ENOG4108YZA	Nitrogen regulatory protein pii
AFE_2253	ENOG4105DN3	alpha-2-macroglobulin domain protein
AFE_2254	ENOG4108JQB	penicillin-binding protein 1C
AFE_2260	ENOG4105DC1	bifunctional purine biosynthesis protein purh
AFE_2261	ENOG4105C12	Phosphoribosylglycinamide synthetase
AFE_2262	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AFE_2263	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
AFE_2264	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
AFE_2269	ENOG4105M8F	Biopolymer transport protein exbD tolR
AFE_2270	ENOG4105E02	MotA TolQ exbB proton channel
AFE_2277	ENOG4105C54	Major Facilitator superfamily
AFE_2282	ENOG4105ENV	phosphonate C-P lyase system protein PhnK
AFE_2283	ENOG4105HRV	phosphonate c-p lyase system protein phnl
AFE_2284	ENOG4105FD8	phosphonate metabolism protein PhnM
AFE_2286	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
AFE_2287	ENOG4105FDP	GntR family transcriptional regulator
AFE_2302	ENOG4108ESX	Receptor
AFE_2312	ENOG4105C54	Major Facilitator superfamily
AFE_2314	ENOG410902C	phosphohistidine phosphatase, SixA
AFE_2318	ENOG4105E0F	Histidine kinase
AFE_2319	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
AFE_2320	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
AFE_2321	ENOG4108M8W	Monooxygenase
AFE_2324	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
AFE_2328	ENOG4105CPW	cytochrome b561
AFE_2332	ENOG4106NZI	LysR family Transcriptional regulator
AFE_2333	ENOG4105D94	Major Facilitator Superfamily
AFE_2336	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AFE_2337	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
AFE_2338	ENOG4105C98	muts2 protein
AFE_2340	ENOG4105VCC	30S ribosomal protein S21
AFE_2341	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
AFE_2342	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AFE_2343	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
AFE_2346	ENOG4105CSA	Coproporphyrinogen iii oxidase
AFE_2349	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
AFE_2350	ENOG4105DZ1	carboxypeptidase
AFE_2355	ENOG4105C8V	SAICAR synthetase
AFE_2358	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
AFE_2360	ENOG4108UT2	hemolysin iii
AFE_2361	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
AFE_2363	ENOG4105VW4	glutaredoxin 3
AFE_2364	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
AFE_2366	ENOG4105BZS	acriflavin resistance protein
AFE_2367	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
AFE_2369	ENOG41080HT	Transcriptional regulator, arsr family
AFE_2381	ENOG4105DZR	Type I site-specific deoxyribonuclease
AFE_2383	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
AFE_2386	ENOG4105CUZ	uba thif-type nad fad binding protein
AFE_2388	ENOG4105D0A	hydroxylase
AFE_2389	ENOG4105D0A	hydroxylase
AFE_2390	ENOG4105W0Z	cytoplasmic protein
AFE_2398	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFE_2399	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFE_2410	ENOG4108HYG	acetyltransferase
AFE_2411	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFE_2420	ENOG4105PGM	cation diffusion facilitator family transporter
AFE_2422	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
AFE_2423	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
AFE_2431	ENOG4108IJF	Heavy metal efflux pump, CzcA
AFE_2443	ENOG4105VNT	transposase (IS4 family) protein
AFE_2448	ENOG4105C59	p-type ATPase
AFE_2450	ENOG4105W2Z	cytochrome C, class I
AFE_2457	ENOG4107QTZ	amino acid
AFE_2462	ENOG4108YZA	Nitrogen regulatory protein pii
AFE_2464	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
AFE_2466	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
AFE_2467	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
AFE_2473	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
AFE_2474	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
AFE_2475	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
AFE_2477	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
AFE_2480	ENOG4108RGV	mercury transport protein MerC
AFE_2481	ENOG4107QN2	dihydrolipoyl dehydrogenase
AFE_2509	ENOG4107SWG	transcriptional regulator MERR family
AFE_2514	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
AFE_2516	ENOG41072GX	Peptidase M22 Glycoprotease
AFE_2517	ENOG4105DVT	helicase
AFE_2520	ENOG4105K4H	Nlp p60 protein
AFE_2524	ENOG4105CE1	Ferrous iron transport protein b
AFE_2527	ENOG4105DQR	SNARE associated Golgi
AFE_2528	ENOG4108Z86	Glutamine amidotransferase
AFE_2531	ENOG4105DUM	transcriptional regulator, lysR family
AFE_2534	ENOG4105DGU	Histone deacetylase
AFE_2535	ENOG4105FAE	von Willebrand factor, type A
AFE_2544	ENOG4107QZT	geranylgeranyl reductase
AFE_2545	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
AFE_2547	ENOG4105PHD	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
AFE_2549	ENOG4105RQ5	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
AFE_2550	ENOG41086B8	CoB-CoM heterodisulfide reductase
AFE_2553	ENOG4105EWK	phytoene
AFE_2556	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
AFE_2557	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
AFE_2558	ENOG41082J7	Rhodanese domain protein
AFE_2559	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
AFE_2561	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
AFE_2562	ENOG4105DFF	Rod shape-determining protein mreb
AFE_2563	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
AFE_2565	ENOG4105CJN	penicillin-binding protein
AFE_2566	ENOG4105CNI	cell division protein FtsW
AFE_2567	ENOG4105DZ1	carboxypeptidase
AFE_2569	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
AFE_2570	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
AFE_2581	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
AFE_2582	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
AFE_2583	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
AFE_2588	ENOG4105WPN	DNA integration recombination invertion protein
AFE_2594	ENOG4108K3A	Glutathione S-transferase
AFE_2595	ENOG4105KVH	Transcriptional regulator
AFE_2596	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
AFE_2597	ENOG4108JUA	Transcriptional regulator
AFE_2604	ENOG4105DA5	(ABC) transporter
AFE_2608	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
AFE_2609	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
AFE_2610	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
AFE_2611	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
AFE_2612	ENOG41082NX	50s ribosomal protein l35
AFE_2613	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
AFE_2614	ENOG4105C22	threonyL-tRNA synthetase
AFE_2617	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFE_2618	ENOG4105C8S	subunit m
AFE_2620	ENOG41080FQ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFE_2621	ENOG4105DF2	NADH dehydrogenase subunit j
AFE_2622	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFE_2623	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
AFE_2627	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFE_2628	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AFE_2629	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AFE_2630	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AFE_2633	ENOG4105CP7	Triose-phosphate isomerase
AFE_2634	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
AFE_2635	ENOG4105EEI	dihydropteroate synthase
AFE_2636	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AFE_2637	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
AFE_2638	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
AFE_2639	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
AFE_2642	ENOG4105C57	major facilitator superfamily
AFE_2651	ENOG4108T5E	Copper resistance protein
AFE_2654	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
AFE_2660	ENOG4105DHP	deoxycytidine triphosphate deaminase
AFE_2663	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
AFE_2664	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
AFE_2665	ENOG4105CFG	Acts as a chaperone (By similarity)
AFE_2666	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFE_2667	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
AFE_2669	ENOG4105W0E	50S ribosomal protein L33
AFE_2670	ENOG4105KDC	50s ribosomal protein l28
AFE_2671	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
AFE_2672	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
AFE_2673	ENOG4105C9Q	fumarate hydratase class II
AFE_2674	ENOG4105DPN	Oligoendopeptidase f
AFE_2678	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
AFE_2679	ENOG4105CY0	Metallo-Beta-Lactamase
AFE_2682	ENOG4105CSM	endonuclease III
AFE_2684	ENOG4105EUR	Domain-Containing protein
AFE_2693	ENOG4108JJA	ABC, transporter
AFE_2696	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
AFE_2716	ENOG4107RDJ	Sulfotransferase
AFE_2722	ENOG4106RZ4	Peptidase U32
AFE_2723	ENOG4105CFP	Peptidase U32
AFE_2724	ENOG4105XPQ	lipid carrier protein
AFE_2727	ENOG41090Y2	cytochrome C
AFE_2729	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
AFE_2730	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
AFE_2731	ENOG4105EIX	cytochrome c1
AFE_2736	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
AFE_2737	ENOG4105HBR	Rna-binding protein
AFE_2738	ENOG4105NWN	ApaG protein
AFE_2739	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
AFE_2743	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
AFE_2746	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFE_2747	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
AFE_2748	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
AFE_2750	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AFE_2751	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
AFE_2752	ENOG4105CAK	Cell division ATP-binding protein ftsE
AFE_2753	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
AFE_2754	ENOG4106H78	methyltransferase
AFE_2755	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
AFE_2756	ENOG410890F	Dynamin family
AFE_2757	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
AFE_2758	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
AFE_2759	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
AFE_2760	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
AFE_2761	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
AFE_2762	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
AFE_2763	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
AFE_2764	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
AFE_2766	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
AFE_2773	ENOG4105CYM	Glutathione S-transferase
AFE_2776	ENOG4105FP9	thiamine pyrophosphate
AFE_2788	ENOG41082CH	UPF0145 protein
AFE_2790	ENOG4105DZR	Type I site-specific deoxyribonuclease
AFE_2791	ENOG4105EKX	Restriction modification system DNA (Specificity
AFE_2793	ENOG4105CVR	type I restriction-modification system
AFE_2798	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
AFE_2800	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
AFE_2815	ENOG4107RAQ	aminopeptidase
AFE_2817	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
AFE_2818	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
AFE_2819	ENOG4105CDU	Replicative dna helicase
AFE_2820	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
AFE_2824	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
AFE_2825	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
AFE_2826	ENOG4105C0X	amino acid
AFE_2828	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
AFE_2832	ENOG4105C6T	cysteine synthase
AFE_2836	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
AFE_2838	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
AFE_2840	ENOG4105C6W	4-alpha-glucanotransferase (EC 2.4.1.25)
AFE_2841	ENOG4105DKQ	ROK family
AFE_2842	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
AFE_2843	ENOG4106BRA	Membrane
AFE_2845	ENOG4108UUM	single-stranded DNA-binding protein
AFE_2847	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
AFE_2848	ENOG4107QR8	Thioredoxin
AFE_2849	ENOG4105C0H	protease
AFE_2850	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AFE_2852	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
AFE_2853	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
AFE_2854	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
AFE_2855	ENOG4105K5M	30s ribosomal protein S16
AFE_2856	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AFE_2857	ENOG4105CAU	Arsenical resistance protein, ArsH
AFE_2860	ENOG4108UXE	Protein tyrosine phosphatase
AFE_2862	ENOG4105CJ1	ABC, transporter
AFE_2863	ENOG4107QWP	ABC-2 type transporter
AFE_2864	ENOG4107QWP	ABC-2 type transporter
AFE_2869	ENOG4105RQ5	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
AFE_2875	ENOG4105CR8	Transcriptional regulator
AFE_2876	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
AFE_2879	ENOG4105UM3	Inherit from NOG: serine threonine phosphoprotein phosphatase
AFE_2880	ENOG4108M24	von Willebrand factor, type A
AFE_2882	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
AFE_2886	ENOG4106A2Z	transcriptional regulator antitoxin, MazE
AFE_2889	ENOG4106A2Z	transcriptional regulator antitoxin, MazE
AFE_2893	ENOG4105C5H	ABC transporter
AFE_2895	ENOG4105CJN	penicillin-binding protein
AFE_2899	ENOG4105EAH	synthase
AFE_2901	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
AFE_2902	ENOG4105CUX	Signal transduction histidine kinase
AFE_2910	ENOG4105CYN	Serine protein kinase
AFE_2911	ENOG4105BZU	Histidine kinase
AFE_2912	ENOG4106AKX	UPF0229 protein
AFE_2913	ENOG4105ED1	spovr family
AFE_2915	ENOG4108YZA	Nitrogen regulatory protein pii
AFE_2916	ENOG4105BZU	Histidine kinase
AFE_2917	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
AFE_2921	ENOG4105K6T	rare lipoprotein A
AFE_2922	ENOG4107SVH	Potassium channel protein
AFE_2923	ENOG4105DZ1	carboxypeptidase
AFE_2924	ENOG4105C89	phosphohexose isomerase
AFE_2926	ENOG4105WMR	Protein CrcB homolog
AFE_2929	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
AFE_2931	ENOG4105DSY	exodeoxyribonuclease V, gamma
AFE_2932	ENOG4107QKA	exodeoxyribonuclease V beta
AFE_2933	ENOG4107QYX	exodeoxyribonuclease v alpha
AFE_2945	ENOG4105E0X	reductase
AFE_2946	ENOG4107U7B	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
AFE_2948	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
AFE_2950	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
AFE_2953	ENOG4108Z03	MAF-like protein
AFE_2954	ENOG4105C03	ribonuclease
AFE_2955	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
AFE_2957	ENOG4107WP9	Histidine kinase
AFE_2959	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
AFE_2962	ENOG4108RDB	capsule polysaccharide export inner-membrane protein
AFE_2967	ENOG4107SBE	Glycosyl transferase (Group 1
AFE_2970	ENOG4105C11	sulfate adenylyltransferase), subunit 2
AFE_2971	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
AFE_2973	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
AFE_2975	ENOG4107V52	polysaccharide export
AFE_2976	ENOG4108TJN	glycosyl transferase group 1
AFE_2977	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
AFE_2985	ENOG4105BZ1	(ABC) transporter
AFE_2986	ENOG41082BV	acetyltransferase
AFE_2989	ENOG4105C3U	ABC transporter
AFE_2990	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
AFE_2999	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
AFE_3000	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
AFE_3003	ENOG4105E02	MotA TolQ exbB proton channel
AFE_3004	ENOG4105M15	transport protein ExbD
AFE_3013	ENOG41084CK	capsule polysaccharide
AFE_3015	ENOG4105CEN	a g-specific adenine glycosylase
AFE_3018	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
AFE_3019	ENOG41080Z8	PHOSPHOCARRIER protein
AFE_3021	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
AFE_3022	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
AFE_3023	ENOG4105DM4	PTS System
AFE_3024	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
AFE_3025	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AFE_3026	ENOG4108IUZ	ABC transporter
AFE_3027	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
AFE_3029	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
AFE_3030	ENOG4105C2X	Arabinose 5-phosphate isomerase
AFE_3032	ENOG4108S0S	Nucleotidyl transferase
AFE_3033	ENOG4105EHM	Aminoglycoside phosphotransferase
AFE_3034	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
AFE_3035	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
AFE_3036	ENOG4105E3A	(ABC) transporter
AFE_3038	ENOG4105M2J	Glutaredoxin
AFE_3039	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
AFE_3040	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
AFE_3041	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
AFE_3042	ENOG4105CIH	Imidazole acetol-phosphate transaminase
AFE_3043	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
AFE_3044	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
AFE_3045	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
AFE_3046	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
AFE_3047	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
AFE_3048	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
AFE_3049	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
AFE_3050	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
AFE_3051	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
AFE_3052	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
AFE_3054	ENOG4105FAE	von Willebrand factor, type A
AFE_3057	ENOG4105BZU	Histidine kinase
AFE_3058	ENOG4105CD3	dihydroorotase
AFE_3059	ENOG4105CXT	aspartate transcarbamylase
AFE_3060	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
AFE_3061	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
AFE_3062	ENOG4108UJU	UPF0301 protein
AFE_3063	ENOG4105D7Z	glutathione synthase
AFE_3065	ENOG4105BZN	citrate synthase
AFE_3067	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
AFE_3068	ENOG4107QN2	dihydrolipoyl dehydrogenase
AFE_3073	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
AFE_3074	ENOG4108UJD	30S ribosomal protein S9
AFE_3075	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
AFE_3085	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
AFE_3086	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
AFE_3089	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
AFE_3092	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
AFE_3093	ENOG4107SVH	Potassium channel protein
AFE_3094	ENOG4105C2M	dna polymerase I
AFE_3097	ENOG4105CUV	Homoserine Kinase
AFE_3100	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
AFE_3101	ENOG4105C4R	Atp-dependent dna helicase
AFE_3104	ENOG4105DCG	PHP domain protein
AFE_3107	ENOG41090Y2	cytochrome C
AFE_3108	ENOG4105UBK	short-chain dehydrogenase reductase
AFE_3109	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
AFE_3110	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
AFE_3113	ENOG4105CRE	cytochrome C
AFE_3121	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
AFE_3122	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
AFE_3125	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
AFE_3126	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
AFE_3136	ENOG4105TX3	Histidine kinase
AFE_3137	ENOG4108UYB	regulatoR
AFE_3142	ENOG4107RDB	Major Facilitator
AFE_3143	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
AFE_3150	ENOG4105Z4T	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
AFE_3152	ENOG41090Y2	cytochrome C
AFE_3158	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
AFE_3161	ENOG4105C5I	Dehydrogenase
AFE_3164	ENOG4105CJ1	ABC, transporter
AFE_3172	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
AFE_3183	ENOG4105EQR	Transposase IS116 IS110 IS902
AFE_3186	ENOG4106H3A	restriction
AFE_3193	ENOG4105ESI	atpase involved in dna repair
AFE_3194	ENOG4105CB5	ATP-dependent DNA helicase recG
AFE_3200	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
AFE_3201	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
AFE_3202	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
AFE_3203	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
AFE_3204	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
AFE_3205	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
AFE_3206	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
AFE_3207	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
AFE_3208	ENOG41082T0	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
AFE_3209	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
AFE_3211	ENOG4105FA0	parb-like partition protein
AFE_3212	ENOG4107QJE	Chromosome Partitioning Protein
AFE_3213	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
AFE_3214	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
AFE_3217	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
AFE_3223	ENOG4105CS1	NAD(P)H quinone oxidoreductase
AFE_3224	ENOG4105EUB	pirin domain protein
AFE_3236	ENOG4105CJ1	ABC, transporter
AFE_3237	ENOG4105DHZ	alpha beta
AFE_3239	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
AFE_3240	ENOG410847I	Transcriptional regulator, BadM Rrf2 family
AFE_3242	ENOG4105DK0	Indole-3-glycerol phosphate synthase
AFE_3243	ENOG4108I0Q	anthranilate phosphoribosyltransferase
AFE_3244	ENOG4105DDQ	anthranilate synthase
AFE_3245	ENOG4105CRQ	synthase (Component I)
AFE_3246	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
AFE_3247	ENOG4105DJV	ribulose-phosphate 3-epimerase
AFE_3248	ENOG4105D2N	Aldolase
AFE_3249	ENOG4105CA9	Pyruvate kinase
AFE_3250	ENOG4105BZA	Phosphoglycerate kinase
AFE_3251	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
AFE_3252	ENOG4105CV1	Transketolase (EC 2.2.1.1)
AFE_3254	ENOG4105ECY	inositol monophosphatase
AFE_3257	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
AFE_3258	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
AFE_3260	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
AFE_3262	ENOG4105BZS	acriflavin resistance protein
AFE_3264	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
AFE_3267	ENOG4108UPT	UPF0178 protein
AFE_3274	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
AFE_3275	ENOG4105E0F	Histidine kinase
AFE_3277	ENOG4105CH7	arginosuccinase
AFE_3279	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
AFE_3280	ENOG4108V1U	phospholipid-binding protein
AFE_3283	ENOG4105E3S	small subunit
AFE_3285	ENOG4105DF6	Fe-S oxidoreductase
AFE_3287	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
AFE_3288	ENOG4107RSS	Hydrogenase accessory protein HypB
AFE_3289	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
AFE_3291	ENOG4108DMA	Nad-dependent epimerase dehydratase
AFE_3292	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
AFE_3293	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
AFE_3294	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
AFE_3298	ENOG4105D52	delta-aminolevulinic acid dehydratase
AFE_3300	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
AFE_3302	ENOG4107ZUX	Histidine triad (HIT) protein
AFE_3303	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
AFE_3304	ENOG4107S5G	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
AFE_3305	ENOG4105DWF	phosphomethylpyrimidine kinase
AFE_3309	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)