locus-tag	class	description
Lferr_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Lferr_0002	COG0592	DNA-directed DNA polymerase activity
Lferr_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Lferr_0004	COG0187	DNA topoisomerase II activity
Lferr_0005	COG0543	2 iron, 2 sulfur cluster binding
Lferr_0005	COG0493	'glutamate synthase
Lferr_0010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Lferr_0012	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Lferr_0014	COG0850	regulation of cytokinetic process
Lferr_0015	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Lferr_0016	COG1754	DNA topoisomerase type I activity
Lferr_0016	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Lferr_0017	COG2922	Belongs to the Smg family
Lferr_0018	COG0758	DNA mediated transformation
Lferr_0020	COG0242	peptide deformylase activity
Lferr_0021	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Lferr_0022	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Lferr_0024	COG5000	phosphorelay sensor kinase activity
Lferr_0025	COG2204	response regulator
Lferr_0028	COG3852	Histidine kinase
Lferr_0029	COG2204	response regulator
Lferr_0030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Lferr_0032	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Lferr_0033	COG0706	membrane insertase activity
Lferr_0034	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Lferr_0036	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Lferr_0037	COG0488	(ABC) transporter
Lferr_0039	COG1566	PFAM secretion protein HlyD family protein
Lferr_0055	COG2095	MarC family integral membrane protein
Lferr_0057	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Lferr_0058	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Lferr_0060	COG0217	transcriptional regulatory protein
Lferr_0061	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Lferr_0062	COG0632	four-way junction helicase activity
Lferr_0063	COG2255	four-way junction helicase activity
Lferr_0064	COG0824	Thioesterase
Lferr_0068	COG0823	Involved in the tonB-independent uptake of proteins
Lferr_0069	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Lferr_0070	COG0602	queuosine metabolic process
Lferr_0072	COG2885	chlorophyll binding
Lferr_0080	COG2226	methyltransferase
Lferr_0086	COG0438	transferase activity, transferring glycosyl groups
Lferr_0094	COG3177	Filamentation induced by cAMP protein fic
Lferr_0100	COG1252	NADH dehydrogenase
Lferr_0103	COG1136	(ABC) transporter
Lferr_0106	COG1914	H( )-stimulated, divalent metal cation uptake system
Lferr_0107	COG2205	protein histidine kinase activity
Lferr_0108	COG0745	RESPONSE REGULATOR receiver
Lferr_0110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Lferr_0111	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Lferr_0122	COG2833	Protein of unknown function (DUF455)
Lferr_0123	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Lferr_0125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Lferr_0126	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Lferr_0127	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Lferr_0137	COG1484	DNA-dependent DNA replication
Lferr_0140	COG0629	single-stranded DNA binding
Lferr_0155	COG1285	pathogenesis
Lferr_0167	COG2217	Heavy metal translocating P-type atpase
Lferr_0172	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Lferr_0180	COG4584	PFAM Integrase catalytic
Lferr_0188	COG1104	cysteine desulfurase activity
Lferr_0189	COG2226	methyltransferase
Lferr_0193	COG2226	methyltransferase
Lferr_0196	COG3385	transposase activity
Lferr_0204	COG1136	(ABC) transporter
Lferr_0204	COG0577	efflux transmembrane transporter activity
Lferr_0205	COG1136	(ABC) transporter
Lferr_0206	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Lferr_0207	COG4232	protein-disulfide reductase activity
Lferr_0208	COG0640	Transcriptional regulator
Lferr_0215	COG4584	PFAM Integrase catalytic
Lferr_0220	COG1484	DNA-dependent DNA replication
Lferr_0228	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Lferr_0233	COG1569	PIN domain
Lferr_0234	COG3311	Transcriptional regulator
Lferr_0244	COG4962	Type ii secretion system protein e
Lferr_0247	COG3451	type IV secretory pathway VirB4
Lferr_0253	COG1872	DUF167
Lferr_0256	COG3701	Conjugal transfer protein
Lferr_0266	COG4372	Transposase
Lferr_0272	COG1475	DNA binding
Lferr_0273	COG1192	Involved in chromosome partitioning
Lferr_0282	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Lferr_0283	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Lferr_0306	COG0583	DNA-binding transcription factor activity
Lferr_0311	COG0859	PFAM glycosyl transferase family 9
Lferr_0313	COG0277	FAD linked oxidase domain protein
Lferr_0314	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Lferr_0315	COG0792	nuclease activity
Lferr_0316	COG3107	peptidoglycan biosynthetic process
Lferr_0324	COG3409	Peptidoglycan-binding domain 1 protein
Lferr_0324	COG3267	Type II secretory pathway component ExeA
Lferr_0327	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Lferr_0328	COG4974	Belongs to the 'phage' integrase family
Lferr_0331	COG2363	Small membrane protein
Lferr_0333	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Lferr_0335	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Lferr_0336	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Lferr_0337	COG1127	ABC transporter
Lferr_0338	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Lferr_0339	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Lferr_0342	COG1131	(ABC) transporter
Lferr_0343	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Lferr_0344	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Lferr_0346	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Lferr_0349	COG0018	arginyl-trna synthetase
Lferr_0351	COG0583	DNA-binding transcription factor activity
Lferr_0353	COG0708	Exodeoxyribonuclease III
Lferr_0355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Lferr_0356	COG0625	glutathione transferase activity
Lferr_0357	COG0708	Exodeoxyribonuclease III
Lferr_0358	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Lferr_0359	COG1047	Peptidyl-prolyl cis-trans
Lferr_0360	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Lferr_0361	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Lferr_0362	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Lferr_0365	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Lferr_0366	COG0237	dephospho-CoA kinase activity
Lferr_0367	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Lferr_0368	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Lferr_0370	COG1196	nuclear chromosome segregation
Lferr_0370	COG0741	lytic transglycosylase activity
Lferr_0370	COG0739	heme binding
Lferr_0371	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Lferr_0373	COG2264	protein methyltransferase activity
Lferr_0374	COG0439	Biotin carboxylase
Lferr_0376	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Lferr_0379	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Lferr_0381	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Lferr_0382	COG1181	Belongs to the D-alanine--D-alanine ligase family
Lferr_0383	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Lferr_0384	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Lferr_0385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Lferr_0386	COG0772	Belongs to the SEDS family
Lferr_0387	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Lferr_0388	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Lferr_0389	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Lferr_0390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Lferr_0393	COG0275	rRNA processing
Lferr_0394	COG2001	Belongs to the MraZ family
Lferr_0397	COG1022	Amp-dependent synthetase and ligase
Lferr_0398	COG0625	glutathione transferase activity
Lferr_0399	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Lferr_0401	COG0653	protein targeting
Lferr_0402	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Lferr_0403	COG0494	nUDIX hydrolase
Lferr_0404	COG0463	Glycosyl transferase, family 2
Lferr_0407	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Lferr_0413	COG1519	Transferase
Lferr_0414	COG1560	Kdo2-lipid A biosynthetic process
Lferr_0415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Lferr_0416	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Lferr_0417	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Lferr_0418	COG1040	competence protein
Lferr_0419	COG0156	8-amino-7-oxononanoate synthase activity
Lferr_0420	COG2267	carboxylic ester hydrolase activity
Lferr_0421	COG2226	methyltransferase
Lferr_0422	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Lferr_0423	COG0501	Belongs to the peptidase M48B family
Lferr_0424	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Lferr_0425	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Lferr_0426	COG0390	transport system, permease component
Lferr_0428	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Lferr_0428	COG0543	2 iron, 2 sulfur cluster binding
Lferr_0432	COG1309	transcriptional regulator
Lferr_0433	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Lferr_0434	COG1566	PFAM secretion protein HlyD family protein
Lferr_0436	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Lferr_0437	COG1872	DUF167
Lferr_0447	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Lferr_0448	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Lferr_0449	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Lferr_0450	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Lferr_0453	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Lferr_0454	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Lferr_0458	COG0735	belongs to the Fur family
Lferr_0459	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Lferr_0460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Lferr_0461	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Lferr_0462	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Lferr_0463	COG0659	secondary active sulfate transmembrane transporter activity
Lferr_0464	COG0288	reversible hydration of carbon dioxide
Lferr_0465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Lferr_0466	COG2226	methyltransferase
Lferr_0468	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Lferr_0468	COG2813	Specifically methylates the guanine in position
Lferr_0469	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Lferr_0471	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Lferr_0472	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Lferr_0473	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Lferr_0473	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Lferr_0476	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Lferr_0477	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Lferr_0481	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Lferr_0483	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Lferr_0486	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Lferr_0487	COG0081	regulation of translation
Lferr_0488	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Lferr_0489	COG0222	ribosome binding
Lferr_0490	COG0085	RNA polymerase activity
Lferr_0491	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Lferr_0492	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Lferr_0493	COG0049	tRNA binding
Lferr_0494	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Lferr_0495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Lferr_0496	COG0051	transcription antitermination factor activity, RNA binding
Lferr_0497	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Lferr_0498	COG0088	Forms part of the polypeptide exit tunnel
Lferr_0499	COG0089	rRNA binding
Lferr_0500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Lferr_0501	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Lferr_0502	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Lferr_0504	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Lferr_0505	COG0255	Belongs to the universal ribosomal protein uL29 family
Lferr_0506	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Lferr_0507	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Lferr_0508	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Lferr_0509	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Lferr_0510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Lferr_0511	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Lferr_0512	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Lferr_0513	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Lferr_0514	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Lferr_0515	COG1841	ribosomal large subunit assembly
Lferr_0516	COG0200	Binds to the 23S rRNA
Lferr_0517	COG0201	protein transport
Lferr_0518	COG0563	adenylate kinase activity
Lferr_0519	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Lferr_0520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Lferr_0521	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Lferr_0522	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Lferr_0523	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Lferr_0524	COG0202	RNA polymerase activity
Lferr_0525	COG0203	ribosomal protein L17
Lferr_0526	COG0756	dUTP diphosphatase activity
Lferr_0527	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Lferr_0528	COG2003	Belongs to the UPF0758 family
Lferr_0530	COG0671	phosphoesterase, PA-phosphatase related
Lferr_0536	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Lferr_0537	COG0678	peroxiredoxin activity
Lferr_0537	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Lferr_0538	COG0560	Phosphoserine phosphatase
Lferr_0539	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Lferr_0540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Lferr_0541	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Lferr_0545	COG0492	ferredoxin-NADP+ reductase activity
Lferr_0547	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Lferr_0549	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Lferr_0550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Lferr_0552	COG1376	ErfK ybiS ycfS ynhG family protein
Lferr_0553	COG0779	Required for maturation of 30S ribosomal subunits
Lferr_0554	COG0195	Participates in both transcription termination and antitermination
Lferr_0555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Lferr_0556	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Lferr_0557	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Lferr_0558	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Lferr_0559	COG1185	polyribonucleotide nucleotidyltransferase activity
Lferr_0560	COG0612	Peptidase, M16
Lferr_0561	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Lferr_0563	COG0328	RNA-DNA hybrid ribonuclease activity
Lferr_0564	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Lferr_0566	COG0346	lactoylglutathione lyase activity
Lferr_0568	COG0137	argininosuccinate synthase activity
Lferr_0569	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Lferr_0570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Lferr_0571	COG0527	aspartate kinase activity
Lferr_0575	COG4115	mRNA cleavage
Lferr_0581	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Lferr_0583	COG0741	lytic transglycosylase activity
Lferr_0583	COG1388	LysM domain
Lferr_0584	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Lferr_0586	COG0538	isocitrate dehydrogenase activity
Lferr_0587	COG0045	succinate-CoA ligase (ADP-forming) activity
Lferr_0589	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Lferr_0590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Lferr_0590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Lferr_0596	COG1850	ribulose-bisphosphate carboxylase activity
Lferr_0597	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
Lferr_0598	COG0235	Class ii aldolase
Lferr_0600	COG0242	peptide deformylase activity
Lferr_0601	COG0531	amino acid
Lferr_0606	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Lferr_0608	COG2204	response regulator
Lferr_0610	COG2205	protein histidine kinase activity
Lferr_0611	COG0497	DNA recombination
Lferr_0612	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Lferr_0613	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Lferr_0614	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Lferr_0614	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Lferr_0615	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Lferr_0617	COG1466	dna polymerase III delta subunit
Lferr_0619	COG0495	leucyl-tRNA aminoacylation
Lferr_0620	COG0655	NAD(P)H dehydrogenase (quinone) activity
Lferr_0621	COG2353	YceI-like domain
Lferr_0622	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Lferr_0623	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Lferr_0625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Lferr_0628	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Lferr_0629	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Lferr_0632	COG0436	Aminotransferase
Lferr_0634	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Lferr_0636	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Lferr_0637	COG4456	Virulence-associated protein
Lferr_0640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Lferr_0642	COG1136	(ABC) transporter
Lferr_0644	COG2333	competence protein COMEC
Lferr_0644	COG0658	competence protein
Lferr_0645	COG0811	peptide transport
Lferr_0646	COG0848	biopolymer transport protein
Lferr_0649	COG1663	tetraacyldisaccharide 4'-kinase activity
Lferr_0650	COG2835	tetraacyldisaccharide 4'-kinase activity
Lferr_0651	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Lferr_0656	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Lferr_0657	COG0667	Aldo Keto reductase
Lferr_0663	COG2329	Antibiotic biosynthesis monooxygenase
Lferr_0667	COG4974	Belongs to the 'phage' integrase family
Lferr_0668	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Lferr_0671	COG3267	Type II secretory pathway component ExeA
Lferr_0671	COG3409	Peptidoglycan-binding domain 1 protein
Lferr_0676	COG1573	uracil-dna glycosylase
Lferr_0677	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Lferr_0678	COG0542	response to heat
Lferr_0679	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Lferr_0680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Lferr_0681	COG0693	protein deglycase activity
Lferr_0682	COG0793	Belongs to the peptidase S41A family
Lferr_0684	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Lferr_0685	COG0058	SHG alpha-glucan phosphorylase activity
Lferr_0687	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Lferr_0690	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Lferr_0691	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Lferr_0696	COG2046	Belongs to the sulfate adenylyltransferase family
Lferr_0696	COG0529	Catalyzes the synthesis of activated sulfate
Lferr_0698	COG0459	protein refolding
Lferr_0699	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Lferr_0704	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Lferr_0706	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Lferr_0710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Lferr_0711	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Lferr_0712	COG0196	riboflavin kinase activity
Lferr_0716	COG1561	YicC-like family, N-terminal region
Lferr_0717	COG0194	GDP metabolic process
Lferr_0718	COG1758	RNA polymerase activity
Lferr_0719	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Lferr_0725	COG0628	permease
Lferr_0726	COG1355	regulation of microtubule-based process
Lferr_0727	COG2078	PFAM AMMECR1 domain protein
Lferr_0729	COG1538	Outer membrane efflux protein
Lferr_0741	COG0513	Belongs to the DEAD box helicase family
Lferr_0742	COG1278	Cold shock
Lferr_0743	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Lferr_0746	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Lferr_0748	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Lferr_0749	COG1702	phosphate starvation-inducible protein PhoH
Lferr_0750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Lferr_0751	COG4535	Mg2 and Co2 transporter CorC
Lferr_0752	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Lferr_0753	COG0312	modulator of DNA gyrase
Lferr_0755	COG1121	(ABC) transporter
Lferr_0757	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Lferr_0766	COG0438	transferase activity, transferring glycosyl groups
Lferr_0767	COG0438	transferase activity, transferring glycosyl groups
Lferr_0768	COG1132	(ABC) transporter
Lferr_0769	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Lferr_0771	COG0406	alpha-ribazole phosphatase activity
Lferr_0771	COG0328	RNA-DNA hybrid ribonuclease activity
Lferr_0774	COG2226	methyltransferase
Lferr_0775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Lferr_0776	COG0066	3-isopropylmalate dehydratase activity
Lferr_0778	COG0259	pyridoxamine-phosphate oxidase activity
Lferr_0779	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Lferr_0781	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Lferr_0782	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Lferr_0785	COG0109	protoheme IX farnesyltransferase activity
Lferr_0786	COG2814	Major facilitator Superfamily
Lferr_0787	COG1968	undecaprenyl-diphosphatase activity
Lferr_0788	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Lferr_0790	COG0505	Belongs to the CarA family
Lferr_0793	COG2022	thiamine diphosphate biosynthetic process
Lferr_0795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Lferr_0796	COG0163	prenyltransferase activity
Lferr_0797	COG1127	ABC transporter
Lferr_0798	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Lferr_0802	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Lferr_0805	COG1136	(ABC) transporter
Lferr_0808	COG0254	rRNA binding
Lferr_0809	COG0281	malic enzyme
Lferr_0810	COG0628	permease
Lferr_0811	COG0129	dihydroxy-acid dehydratase activity
Lferr_0813	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Lferr_0813	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Lferr_0814	COG0271	Belongs to the BolA IbaG family
Lferr_0815	COG2350	Protein conserved in bacteria
Lferr_0816	COG2917	probably involved in intracellular septation
Lferr_0819	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Lferr_0821	COG1959	2 iron, 2 sulfur cluster binding
Lferr_0822	COG1104	cysteine desulfurase activity
Lferr_0823	COG0822	iron-sulfur transferase activity
Lferr_0825	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Lferr_0826	COG0443	Heat shock 70 kDa protein
Lferr_0829	COG0482	sulfurtransferase activity
Lferr_0830	COG1752	Esterase of the alpha-beta hydrolase superfamily
Lferr_0835	COG0732	type I restriction modification DNA specificity domain
Lferr_0839	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Lferr_0842	COG3284	Transcriptional regulator
Lferr_0844	COG3791	Glutathione-dependent formaldehyde-activating
Lferr_0845	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Lferr_0846	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Lferr_0847	COG0583	DNA-binding transcription factor activity
Lferr_0848	COG2204	response regulator
Lferr_0858	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Lferr_0861	COG0298	carbon dioxide binding
Lferr_0862	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Lferr_0865	COG0375	protein maturation
Lferr_0870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Lferr_0876	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Lferr_0877	COG0493	'glutamate synthase
Lferr_0878	COG0070	glutamate synthase
Lferr_0878	COG0067	glutamate synthase
Lferr_0878	COG0069	glutamate synthase activity
Lferr_0879	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Lferr_0880	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Lferr_0881	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Lferr_0882	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Lferr_0888	COG0590	tRNA wobble adenosine to inosine editing
Lferr_0889	COG0432	Pfam Uncharacterised protein family UPF0047
Lferr_0891	COG1193	negative regulation of DNA recombination
Lferr_0892	COG0028	Belongs to the TPP enzyme family
Lferr_0894	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Lferr_0895	COG0688	phosphatidylethanolamine metabolic process
Lferr_0896	COG1183	phosphatidylcholine synthase activity
Lferr_0898	COG0589	response to stress
Lferr_0899	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Lferr_0900	COG1196	nuclear chromosome segregation
Lferr_0903	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Lferr_0909	COG0730	response to heat
Lferr_0911	COG0811	peptide transport
Lferr_0915	COG0402	S-adenosylhomocysteine deaminase activity
Lferr_0916	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Lferr_0923	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Lferr_0923	COG3608	succinylglutamate desuccinylase aspartoacylase
Lferr_0927	COG0746	molybdenum cofactor guanylyltransferase activity
Lferr_0935	COG0475	glutathione-regulated potassium exporter activity
Lferr_0936	COG1028	Short-chain dehydrogenase reductase Sdr
Lferr_0952	COG2080	2 iron, 2 sulfur cluster binding
Lferr_0952	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Lferr_0955	COG2814	Major facilitator Superfamily
Lferr_0956	COG0038	chloride channel
Lferr_0958	COG0583	DNA-binding transcription factor activity
Lferr_0968	COG1196	nuclear chromosome segregation
Lferr_0969	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Lferr_0972	COG1064	alcohol dehydrogenase
Lferr_0973	COG0504	CTP synthase activity
Lferr_0974	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Lferr_0975	COG0148	phosphopyruvate hydratase activity
Lferr_0976	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Lferr_0977	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Lferr_0979	COG0322	excinuclease ABC activity
Lferr_0982	COG3189	MarR family transcriptional regulator
Lferr_0985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Lferr_0985	COG1017	nitric oxide dioxygenase activity
Lferr_0986	COG1566	PFAM secretion protein HlyD family protein
Lferr_0987	COG1538	Outer membrane efflux protein
Lferr_0988	COG2814	Major facilitator Superfamily
Lferr_0989	COG0583	DNA-binding transcription factor activity
Lferr_0994	COG2161	toxin-antitoxin pair type II binding
Lferr_0997	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Lferr_1001	COG1247	-acetyltransferase
Lferr_1010	COG0393	Putative heavy-metal-binding
Lferr_1012	COG2026	Addiction module toxin, RelE StbE family
Lferr_1014	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Lferr_1015	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Lferr_1017	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Lferr_1018	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Lferr_1020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Lferr_1021	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Lferr_1022	COG0287	Prephenate dehydrogenase
Lferr_1023	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Lferr_1024	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Lferr_1026	COG0776	regulation of translation
Lferr_1027	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Lferr_1028	COG0284	orotidine-5'-phosphate decarboxylase activity
Lferr_1029	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Lferr_1030	COG0544	peptidyl-prolyl cis-trans isomerase activity
Lferr_1032	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Lferr_1033	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Lferr_1036	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Lferr_1037	COG0671	phosphoesterase, PA-phosphatase related
Lferr_1042	COG2915	High frequency lysogenization protein hflD homolog
Lferr_1043	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Lferr_1044	COG0024	Methionine aminopeptidase
Lferr_1045	COG1489	DNA binding
Lferr_1046	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Lferr_1048	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Lferr_1050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Lferr_1051	COG2137	regulation of response to DNA damage stimulus
Lferr_1059	COG1196	nuclear chromosome segregation
Lferr_1059	COG0739	heme binding
Lferr_1059	COG0741	lytic transglycosylase activity
Lferr_1060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Lferr_1063	COG0488	(ABC) transporter
Lferr_1064	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Lferr_1069	COG1294	oxidase, subunit
Lferr_1074	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Lferr_1077	COG2943	transferase activity, transferring hexosyl groups
Lferr_1077	COG3416	Protein conserved in bacteria
Lferr_1079	COG2363	Small membrane protein
Lferr_1088	COG0616	signal peptide processing
Lferr_1089	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Lferr_1090	COG0314	molybdopterin synthase activity
Lferr_1091	COG1666	GTP binding
Lferr_1093	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Lferr_1094	COG0509	glycine decarboxylation via glycine cleavage system
Lferr_1095	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Lferr_1096	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Lferr_1097	COG1132	(ABC) transporter
Lferr_1098	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Lferr_1099	COG0450	alkyl hydroperoxide reductase
Lferr_1101	COG0613	PHP domain protein
Lferr_1102	COG0628	permease
Lferr_1106	COG0084	hydrolase, TatD family'
Lferr_1107	COG0321	lipoyl(octanoyl) transferase activity
Lferr_1107	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Lferr_1109	COG4988	ABC transporter
Lferr_1110	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Lferr_1112	COG0354	folic acid binding
Lferr_1114	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Lferr_1117	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Lferr_1118	COG0481	GTPase activity
Lferr_1119	COG0681	Belongs to the peptidase S26 family
Lferr_1121	COG0571	ribonuclease III activity
Lferr_1122	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Lferr_1123	COG1381	Involved in DNA repair and RecF pathway recombination
Lferr_1124	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Lferr_1125	COG0736	holo-[acyl-carrier-protein] synthase activity
Lferr_1129	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Lferr_1129	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Lferr_1130	COG0037	tRNA processing
Lferr_1131	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Lferr_1143	COG0438	transferase activity, transferring glycosyl groups
Lferr_1147	COG1230	cation diffusion facilitator family transporter
Lferr_1150	COG0513	Belongs to the DEAD box helicase family
Lferr_1153	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Lferr_1154	COG0573	inorganic phosphate transmembrane transporter activity
Lferr_1155	COG0581	inorganic phosphate transmembrane transporter activity
Lferr_1156	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Lferr_1157	COG0704	Plays a role in the regulation of phosphate uptake
Lferr_1160	COG0052	Belongs to the universal ribosomal protein uS2 family
Lferr_1161	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Lferr_1162	COG0528	UMP kinase activity
Lferr_1164	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Lferr_1165	COG0575	Belongs to the CDS family
Lferr_1166	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Lferr_1170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Lferr_1171	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Lferr_1172	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Lferr_1173	COG0673	inositol 2-dehydrogenase activity
Lferr_1175	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Lferr_1176	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Lferr_1178	COG0825	malonyl-CoA metabolic process
Lferr_1179	COG0037	tRNA processing
Lferr_1181	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Lferr_1182	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Lferr_1184	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Lferr_1185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Lferr_1186	COG1166	arginine decarboxylase activity
Lferr_1195	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Lferr_1200	COG0811	peptide transport
Lferr_1206	COG1120	ATPase activity
Lferr_1211	COG0725	ABC transporter, periplasmic molybdate-binding protein
Lferr_1213	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Lferr_1216	COG0725	ABC transporter, periplasmic molybdate-binding protein
Lferr_1220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Lferr_1231	COG5420	small protein containing a coiled-coil domain
Lferr_1234	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Lferr_1235	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Lferr_1238	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Lferr_1239	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Lferr_1240	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Lferr_1246	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Lferr_1247	COG0316	Belongs to the HesB IscA family
Lferr_1253	COG1104	cysteine desulfurase activity
Lferr_1254	COG5554	nitrogen fixation
Lferr_1256	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Lferr_1257	COG0633	Ferredoxin
Lferr_1262	COG1012	belongs to the aldehyde dehydrogenase family
Lferr_1266	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Lferr_1267	COG0438	transferase activity, transferring glycosyl groups
Lferr_1268	COG0438	transferase activity, transferring glycosyl groups
Lferr_1269	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Lferr_1271	COG4974	Belongs to the 'phage' integrase family
Lferr_1277	COG1484	DNA-dependent DNA replication
Lferr_1280	COG0629	single-stranded DNA binding
Lferr_1284	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Lferr_1285	COG1061	Type III restriction enzyme res subunit
Lferr_1287	COG1002	Type II restriction enzyme, methylase subunits
Lferr_1293	COG0776	regulation of translation
Lferr_1294	COG0776	regulation of translation
Lferr_1299	COG3077	Addiction module antitoxin, RelB DinJ family
Lferr_1326	COG4372	Transposase
Lferr_1331	COG3657	addiction module killer protein
Lferr_1332	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Lferr_1334	COG4962	Type ii secretion system protein e
Lferr_1339	COG3451	type IV secretory pathway VirB4
Lferr_1346	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Lferr_1349	COG2084	Dehydrogenase
Lferr_1350	COG0243	molybdopterin cofactor binding
Lferr_1352	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Lferr_1354	COG0633	Ferredoxin
Lferr_1354	COG0543	2 iron, 2 sulfur cluster binding
Lferr_1355	COG1151	hydroxylamine reductase activity
Lferr_1358	COG3002	Belongs to the UPF0753 family
Lferr_1359	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Lferr_1360	COG0247	lactate metabolic process
Lferr_1361	COG0277	FAD linked oxidase domain protein
Lferr_1362	COG0277	FAD linked oxidase domain protein
Lferr_1369	COG0418	dihydroorotase activity
Lferr_1370	COG0129	dihydroxy-acid dehydratase activity
Lferr_1371	COG0009	L-threonylcarbamoyladenylate synthase
Lferr_1373	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Lferr_1378	COG1192	Involved in chromosome partitioning
Lferr_1389	COG1850	ribulose-bisphosphate carboxylase activity
Lferr_1392	COG3701	Conjugal transfer protein
Lferr_1410	COG1475	DNA binding
Lferr_1411	COG1192	Involved in chromosome partitioning
Lferr_1414	COG0667	Aldo Keto reductase
Lferr_1424	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Lferr_1425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Lferr_1432	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Lferr_1434	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Lferr_1439	COG1666	GTP binding
Lferr_1440	COG0438	transferase activity, transferring glycosyl groups
Lferr_1441	COG0670	Belongs to the BI1 family
Lferr_1446	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Lferr_1447	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Lferr_1448	COG1428	Deoxynucleoside kinase
Lferr_1450	COG0617	tRNA 3'-terminal CCA addition
Lferr_1452	COG0463	Glycosyl transferase, family 2
Lferr_1454	COG0519	Catalyzes the synthesis of GMP from XMP
Lferr_1454	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Lferr_1455	COG4691	Plasmid stability protein
Lferr_1456	COG1487	ribonuclease activity
Lferr_1459	COG0531	amino acid
Lferr_1460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Lferr_1461	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Lferr_1461	COG3264	Mechanosensitive ion channel
Lferr_1464	COG0009	L-threonylcarbamoyladenylate synthase
Lferr_1465	COG1994	Peptidase M50
Lferr_1466	COG0180	Tryptophanyl-tRNA synthetase
Lferr_1467	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Lferr_1468	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Lferr_1469	COG0446	pyridine nucleotide-disulphide oxidoreductase
Lferr_1470	COG1187	pseudouridine synthase activity
Lferr_1474	COG2814	Major facilitator Superfamily
Lferr_1482	COG1105	Belongs to the carbohydrate kinase PfkB family
Lferr_1483	COG0280	phosphate acetyltransferase
Lferr_1484	COG0477	Major facilitator Superfamily
Lferr_1488	COG0508	dehydrogenase complex catalyzes the overall conversion of
Lferr_1489	COG0022	dehydrogenase e1 component
Lferr_1490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Lferr_1492	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Lferr_1493	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Lferr_1493	COG0574	Belongs to the PEP-utilizing enzyme family
Lferr_1496	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Lferr_1497	COG2171	N-acyltransferase activity
Lferr_1501	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Lferr_1502	COG0402	S-adenosylhomocysteine deaminase activity
Lferr_1504	COG0791	NLP P60 protein
Lferr_1504	COG1388	LysM domain
Lferr_1508	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Lferr_1515	COG1484	DNA-dependent DNA replication
Lferr_1516	COG4584	PFAM Integrase catalytic
Lferr_1527	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Lferr_1529	COG1216	Glycosyl transferase, family 2
Lferr_1534	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Lferr_1535	COG1028	Short-chain dehydrogenase reductase Sdr
Lferr_1537	COG2154	pterin-4-alpha-carbinolamine dehydratase
Lferr_1543	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Lferr_1546	COG0587	DNA-directed DNA polymerase activity
Lferr_1548	COG0308	aminopeptidase N
Lferr_1551	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Lferr_1552	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Lferr_1553	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Lferr_1554	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Lferr_1557	COG0424	maF-like protein
Lferr_1558	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Lferr_1559	COG1923	regulation of RNA biosynthetic process
Lferr_1560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Lferr_1561	COG0330	HflC and HflK could
Lferr_1562	COG0330	HflC and HflK could
Lferr_1563	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Lferr_1567	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Lferr_1568	COG1546	Belongs to the CinA family
Lferr_1568	COG1058	Belongs to the CinA family
Lferr_1570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Lferr_1572	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Lferr_1573	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Lferr_1575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Lferr_1576	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Lferr_1579	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Lferr_1580	COG0416	fatty acid biosynthetic process
Lferr_1581	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Lferr_1582	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Lferr_1584	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Lferr_1585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Lferr_1587	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Lferr_1588	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Lferr_1592	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Lferr_1593	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Lferr_1594	COG0004	ammonium transporteR
Lferr_1595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Lferr_1595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Lferr_1596	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Lferr_1598	COG0802	atpase or kinase
Lferr_1599	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Lferr_1600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Lferr_1601	COG0105	UTP biosynthetic process
Lferr_1602	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Lferr_1605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Lferr_1606	COG0124	histidyl-tRNA synthetase
Lferr_1609	COG1160	GTP binding
Lferr_1616	COG0730	response to heat
Lferr_1617	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Lferr_1620	COG1881	PFAM PEBP family protein
Lferr_1622	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Lferr_1626	COG0729	surface antigen
Lferr_1630	COG4654	Cytochrome c, class I
Lferr_1635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Lferr_1637	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Lferr_1640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Lferr_1641	COG1469	GTP cyclohydrolase I activity
Lferr_1642	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Lferr_1643	COG0142	geranyltranstransferase activity
Lferr_1645	COG2223	nitrite transmembrane transporter activity
Lferr_1647	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Lferr_1648	COG1570	exodeoxyribonuclease VII activity
Lferr_1649	COG4993	Dehydrogenase
Lferr_1649	COG2010	Cytochrome c
Lferr_1655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Lferr_1656	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Lferr_1657	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Lferr_1658	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Lferr_1662	COG0583	DNA-binding transcription factor activity
Lferr_1663	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Lferr_1664	COG2197	response regulator
Lferr_1666	COG3916	Acyl-homoserine-lactone synthase
Lferr_1680	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Lferr_1681	COG0456	acetyltransferase
Lferr_1686	COG2217	Heavy metal translocating P-type atpase
Lferr_1689	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Lferr_1690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Lferr_1691	COG0640	Transcriptional regulator
Lferr_1692	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Lferr_1694	COG0187	DNA topoisomerase II activity
Lferr_1695	COG0642	Histidine kinase
Lferr_1696	COG0745	RESPONSE REGULATOR receiver
Lferr_1712	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Lferr_1714	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Lferr_1715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Lferr_1716	COG1862	Preprotein translocase
Lferr_1717	COG0343	queuine tRNA-ribosyltransferase activity
Lferr_1718	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Lferr_1719	COG1253	flavin adenine dinucleotide binding
Lferr_1722	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Lferr_1724	COG0285	dihydrofolate synthase activity
Lferr_1725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Lferr_1726	COG0159	tryptophan synthase activity
Lferr_1727	COG0133	tryptophan synthase activity
Lferr_1728	COG0135	phosphoribosylanthranilate isomerase activity
Lferr_1729	COG0101	tRNA pseudouridine synthase activity
Lferr_1731	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Lferr_1733	COG0746	molybdenum cofactor guanylyltransferase activity
Lferr_1734	COG1763	Mo-molybdopterin cofactor biosynthetic process
Lferr_1735	COG0303	'Molybdopterin
Lferr_1737	COG0616	signal peptide processing
Lferr_1740	COG0438	transferase activity, transferring glycosyl groups
Lferr_1746	COG0501	Belongs to the peptidase M48B family
Lferr_1747	COG0477	Major facilitator Superfamily
Lferr_1756	COG4372	Transposase
Lferr_1760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Lferr_1761	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Lferr_1769	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Lferr_1770	COG0154	amidase activity
Lferr_1771	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Lferr_1778	COG3394	polysaccharide catabolic process
Lferr_1781	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Lferr_1782	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Lferr_1783	COG1657	PFAM Prenyltransferase squalene oxidase
Lferr_1784	COG1562	ergosterol biosynthetic process
Lferr_1785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Lferr_1786	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Lferr_1790	COG1012	belongs to the aldehyde dehydrogenase family
Lferr_1791	COG0442	prolyl-tRNA aminoacylation
Lferr_1795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Lferr_1798	COG1692	metallophosphoesterase
Lferr_1799	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Lferr_1802	COG0768	penicillin binding
Lferr_1803	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Lferr_1804	COG0193	aminoacyl-tRNA hydrolase activity
Lferr_1805	COG0012	GTP binding
Lferr_1806	COG1396	sequence-specific DNA binding
Lferr_1807	COG0651	ATP synthesis coupled electron transport
Lferr_1808	COG0650	Formate hydrogenlyase subunit 4
Lferr_1810	COG0651	ATP synthesis coupled electron transport
Lferr_1811	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Lferr_1811	COG3261	NADH dehydrogenase
Lferr_1812	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Lferr_1814	COG1850	ribulose-bisphosphate carboxylase activity
Lferr_1818	COG2824	Alkylphosphonate utilization operon protein PhnA
Lferr_1819	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Lferr_1828	COG0726	polysaccharide deacetylase
Lferr_1828	COG1649	PFAM Uncharacterised BCR, COG1649
Lferr_1830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Lferr_1831	COG0494	nUDIX hydrolase
Lferr_1833	COG1187	pseudouridine synthase activity
Lferr_1834	COG2957	Belongs to the agmatine deiminase family
Lferr_1835	COG0243	molybdopterin cofactor binding
Lferr_1841	COG0589	response to stress
Lferr_1842	COG2814	Major facilitator Superfamily
Lferr_1845	COG0210	DNA helicase
Lferr_1846	COG0268	Binds directly to 16S ribosomal RNA
Lferr_1847	COG3842	ATPase activity
Lferr_1850	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Lferr_1851	COG0514	ATP-dependent DNA helicase (RecQ)
Lferr_1852	COG1965	Belongs to the frataxin family
Lferr_1856	COG0795	lipopolysaccharide-transporting ATPase activity
Lferr_1857	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Lferr_1860	COG0525	valine-tRNA ligase activity
Lferr_1861	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Lferr_1865	COG0412	Dienelactone hydrolase
Lferr_1866	COG1902	pentaerythritol trinitrate reductase activity
Lferr_1868	COG3152	Membrane
Lferr_1874	COG1530	ribonuclease E activity
Lferr_1875	COG0215	cysteine-tRNA ligase activity
Lferr_1876	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Lferr_1879	COG1028	Short-chain dehydrogenase reductase Sdr
Lferr_1883	COG0745	RESPONSE REGULATOR receiver
Lferr_1884	COG2205	protein histidine kinase activity
Lferr_1885	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Lferr_1886	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Lferr_1887	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Lferr_1889	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Lferr_1901	COG4953	penicillin-binding protein 1C
Lferr_1907	COG0138	bifunctional purine biosynthesis protein purh
Lferr_1908	COG0151	Belongs to the GarS family
Lferr_1909	COG0009	L-threonylcarbamoyladenylate synthase
Lferr_1910	COG0408	coproporphyrinogen oxidase activity
Lferr_1911	COG0167	dihydroorotate dehydrogenase activity
Lferr_1917	COG0811	peptide transport
Lferr_1920	COG0811	peptide transport
Lferr_1924	COG0477	Major facilitator Superfamily
Lferr_1925	COG3624	Phosphonate C-P lyase system protein PhnG
Lferr_1926	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
Lferr_1927	COG3626	phosphonate metabolism
Lferr_1928	COG3627	carbon phosphorus lyase activity
Lferr_1929	COG4107	phosphonate C-P lyase system protein PhnK
Lferr_1930	COG4778	phosphonate C-P lyase system protein PhnL
Lferr_1931	COG3454	Phosphonate metabolism
Lferr_1934	COG2188	Transcriptional regulator
Lferr_1940	COG3511	phospholipase C
Lferr_1942	COG0811	peptide transport
Lferr_1945	COG4774	siderophore transport
Lferr_1953	COG2814	Major facilitator Superfamily
Lferr_1955	COG2062	phosphohistidine phosphatase, SixA
Lferr_1957	COG2205	protein histidine kinase activity
Lferr_1958	COG0745	RESPONSE REGULATOR receiver
Lferr_1959	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Lferr_1960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Lferr_1963	COG0033	Phosphoglucomutase
Lferr_1966	COG3038	cytochrome b561
Lferr_1968	COG2814	Major facilitator Superfamily
Lferr_1969	COG0583	DNA-binding transcription factor activity
Lferr_1972	COG1193	negative regulation of DNA recombination
Lferr_1974	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Lferr_1976	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Lferr_1977	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Lferr_1980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Lferr_1985	COG1686	Belongs to the peptidase S11 family
Lferr_1989	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Lferr_1990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Lferr_1992	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Lferr_1993	COG1272	protein, Hemolysin III
Lferr_1994	COG0860	N-Acetylmuramoyl-L-alanine amidase
Lferr_1996	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Lferr_1997	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Lferr_1999	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Lferr_2000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Lferr_2002	COG0640	Transcriptional regulator
Lferr_2012	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Lferr_2013	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Lferr_2016	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Lferr_2018	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Lferr_2019	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Lferr_2027	COG1484	DNA-dependent DNA replication
Lferr_2028	COG4584	PFAM Integrase catalytic
Lferr_2030	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Lferr_2031	COG4974	Belongs to the 'phage' integrase family
Lferr_2040	COG0454	-acetyltransferase
Lferr_2042	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Lferr_2050	COG1230	cation diffusion facilitator family transporter
Lferr_2060	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Lferr_2074	COG2217	Heavy metal translocating P-type atpase
Lferr_2076	COG4654	Cytochrome c, class I
Lferr_2082	COG0531	amino acid
Lferr_2086	COG0347	Belongs to the P(II) protein family
Lferr_2088	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Lferr_2089	COG0189	ligase activity
Lferr_2089	COG0569	domain protein
Lferr_2093	COG4372	Transposase
Lferr_2100	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Lferr_2101	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Lferr_2102	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Lferr_2104	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Lferr_2109	COG0789	Transcriptional regulator
Lferr_2133	COG1959	2 iron, 2 sulfur cluster binding
Lferr_2140	COG0789	Transcriptional regulator
Lferr_2147	COG1199	ATP-dependent helicase activity
Lferr_2149	COG0791	NLP P60 protein
Lferr_2152	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Lferr_2155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Lferr_2156	COG0586	Pfam SNARE associated Golgi protein
Lferr_2162	COG0123	including yeast histone deacetylase and acetoin utilization protein
Lferr_2172	COG0644	oxidoreductase
Lferr_2173	COG0095	Lipoate-protein ligase
Lferr_2175	COG0509	glycine decarboxylation via glycine cleavage system
Lferr_2177	COG0509	glycine decarboxylation via glycine cleavage system
Lferr_2178	COG2048	Heterodisulfide reductase, subunit B
Lferr_2186	COG2210	Belongs to the sulfur carrier protein TusA family
Lferr_2187	COG0425	Belongs to the sulfur carrier protein TusA family
Lferr_2188	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Lferr_2189	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Lferr_2191	COG0315	cyclic pyranopterin monophosphate synthase activity
Lferr_2192	COG1077	Cell shape determining protein MreB Mrl
Lferr_2193	COG1792	Involved in formation and maintenance of cell shape
Lferr_2195	COG0768	penicillin binding
Lferr_2196	COG0772	Belongs to the SEDS family
Lferr_2197	COG1686	Belongs to the peptidase S11 family
Lferr_2199	COG0321	lipoyl(octanoyl) transferase activity
Lferr_2200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Lferr_2210	COG0751	glycine-tRNA ligase activity
Lferr_2211	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Lferr_2213	COG0189	ligase activity
Lferr_2217	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Lferr_2223	COG0625	glutathione transferase activity
Lferr_2224	COG1733	regulation of RNA biosynthetic process
Lferr_2225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Lferr_2233	COG1131	(ABC) transporter
Lferr_2237	COG0776	regulation of translation
Lferr_2238	COG0072	phenylalanine-tRNA ligase activity
Lferr_2238	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Lferr_2239	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Lferr_2240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Lferr_2241	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Lferr_2242	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Lferr_2243	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Lferr_2244	COG1007	ATP synthesis coupled electron transport
Lferr_2247	COG0713	ATP synthesis coupled electron transport
Lferr_2249	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Lferr_2250	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Lferr_2251	COG1034	ATP synthesis coupled electron transport
Lferr_2253	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Lferr_2254	COG0649	NAD binding
Lferr_2255	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Lferr_2256	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Lferr_2257	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Lferr_2258	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Lferr_2259	COG0149	triose-phosphate isomerase activity
Lferr_2260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Lferr_2261	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Lferr_2262	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Lferr_2263	COG0312	modulator of DNA gyrase
Lferr_2264	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Lferr_2264	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Lferr_2265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Lferr_2268	COG0477	Major facilitator Superfamily
Lferr_2280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Lferr_2286	COG0717	Belongs to the dCTP deaminase family
Lferr_2287	COG0489	protein tyrosine kinase activity
Lferr_2289	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Lferr_2290	COG0484	heat shock protein binding
Lferr_2291	COG0443	Heat shock 70 kDa protein
Lferr_2292	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Lferr_2293	COG1420	regulation of RNA biosynthetic process
Lferr_2294	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Lferr_2295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Lferr_2296	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Lferr_2296	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Lferr_2297	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Lferr_2298	COG0114	fumarate hydratase activity
Lferr_2303	COG0297	glycogen (starch) synthase activity
Lferr_2304	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Lferr_2306	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Lferr_2315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Lferr_2318	COG2204	response regulator
Lferr_2326	COG4964	Belongs to the GSP D family
Lferr_2338	COG0457	Tetratricopeptide repeat
Lferr_2350	COG1028	Short-chain dehydrogenase reductase Sdr
Lferr_2351	COG0723	plastoquinol--plastocyanin reductase activity
Lferr_2352	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Lferr_2353	COG2857	Cytochrome c1
Lferr_2357	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Lferr_2358	COG1534	Rna-binding protein
Lferr_2359	COG2967	ApaG domain
Lferr_2360	COG2226	methyltransferase
Lferr_2363	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Lferr_2366	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Lferr_2368	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Lferr_2371	COG2177	Part of the ABC transporter FtsEX involved in
Lferr_2372	COG2884	Cell division ATP-binding protein ftsE
Lferr_2373	COG0552	protein localization to endoplasmic reticulum
Lferr_2374	COG0742	ribosomal rna small subunit methyltransferase
Lferr_2375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Lferr_2376	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Lferr_2377	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Lferr_2378	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Lferr_2379	COG2890	protein-(glutamine-N5) methyltransferase activity
Lferr_2380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Lferr_2381	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Lferr_2383	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Lferr_2384	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Lferr_2385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Lferr_2391	COG1487	ribonuclease activity
Lferr_2400	COG1484	DNA-dependent DNA replication
Lferr_2401	COG4584	PFAM Integrase catalytic
Lferr_2411	COG0393	Putative heavy-metal-binding
Lferr_2413	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Lferr_2415	COG0732	type I restriction modification DNA specificity domain
Lferr_2418	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Lferr_2422	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Lferr_2438	COG0006	proline dipeptidase activity
Lferr_2441	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Lferr_2442	COG0305	Participates in initiation and elongation during chromosome replication
Lferr_2443	COG0359	binds to the 23S rRNA
Lferr_2446	COG0360	Binds together with S18 to 16S ribosomal RNA
Lferr_2447	COG1472	Belongs to the glycosyl hydrolase 3 family
Lferr_2448	COG0531	amino acid
Lferr_2450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Lferr_2455	COG0363	glucosamine-6-phosphate deaminase activity
Lferr_2458	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Lferr_2459	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Lferr_2461	COG1449	Belongs to the glycosyl hydrolase 57 family
Lferr_2462	COG1940	carbohydrate kinase activity
Lferr_2463	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Lferr_2464	COG2733	membrane
Lferr_2466	COG0629	single-stranded DNA binding
Lferr_2469	COG3118	belongs to the thioredoxin family
Lferr_2470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Lferr_2473	COG0335	large ribosomal subunit rRNA binding
Lferr_2474	COG0336	Belongs to the RNA methyltransferase TrmD family
Lferr_2475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Lferr_2476	COG0228	four-way junction DNA binding
Lferr_2477	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Lferr_2478	COG0431	NADPH-dependent FMN reductase
Lferr_2481	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Lferr_2483	COG1131	(ABC) transporter
Lferr_2484	COG0842	Transport permease protein
Lferr_2485	COG0842	Transport permease protein
Lferr_2490	COG0509	glycine decarboxylation via glycine cleavage system
Lferr_2494	COG0583	DNA-binding transcription factor activity
Lferr_2495	COG2210	Belongs to the sulfur carrier protein TusA family
Lferr_2498	COG0631	protein serine/threonine phosphatase activity
Lferr_2499	COG4245	von Willebrand factor, type A
Lferr_2502	COG1573	uracil-dna glycosylase
Lferr_2506	COG2336	PFAM SpoVT AbrB
Lferr_2509	COG2336	PFAM SpoVT AbrB
Lferr_2517	COG0142	geranyltranstransferase activity
Lferr_2520	COG3852	Histidine kinase
Lferr_2522	COG2308	Evidence 4 Homologs of previously reported genes of
Lferr_2525	COG2766	serine protein kinase
Lferr_2526	COG0004	ammonium transporteR
Lferr_2527	COG2718	Belongs to the UPF0229 family
Lferr_2528	COG2719	SpoVR family
Lferr_2530	COG0347	Belongs to the P(II) protein family
Lferr_2531	COG0004	ammonium transporteR
Lferr_2532	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Lferr_2532	COG0519	Catalyzes the synthesis of GMP from XMP
Lferr_2535	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Lferr_2537	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Lferr_2538	COG1686	Belongs to the peptidase S11 family
Lferr_2539	COG0166	Belongs to the GPI family
Lferr_2541	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Lferr_2544	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Lferr_2546	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Lferr_2547	COG1074	ATP-dependent DNA helicase activity
Lferr_2548	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Lferr_2558	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Lferr_2559	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Lferr_2561	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Lferr_2563	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Lferr_2566	COG0424	maF-like protein
Lferr_2567	COG1530	ribonuclease E activity
Lferr_2568	COG2204	response regulator
Lferr_2570	COG2205	protein histidine kinase activity
Lferr_2572	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Lferr_2579	COG0438	transferase activity, transferring glycosyl groups
Lferr_2586	COG2895	sulfate adenylyltransferase (ATP) activity
Lferr_2586	COG0529	Catalyzes the synthesis of activated sulfate
Lferr_2598	COG1132	(ABC) transporter
Lferr_2599	COG2153	protein acetylation
Lferr_2602	COG0444	Belongs to the ABC transporter superfamily
Lferr_2603	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Lferr_2604	COG0601	transmembrane transport
Lferr_2609	COG2095	MarC family integral membrane protein
Lferr_2613	COG0811	peptide transport
Lferr_2614	COG0848	biopolymer transport protein
Lferr_2617	COG3321	synthase
Lferr_2617	COG1028	Short-chain dehydrogenase reductase Sdr
Lferr_2617	COG0604	alcohol dehydrogenase
Lferr_2618	COG0156	8-amino-7-oxononanoate synthase activity
Lferr_2623	COG1194	a g-specific adenine glycosylase
Lferr_2625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Lferr_2626	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Lferr_2629	COG1660	Displays ATPase and GTPase activities
Lferr_2630	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Lferr_2631	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Lferr_2631	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Lferr_2631	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Lferr_2635	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Lferr_2637	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Lferr_2642	COG3178	'Phosphotransferase
Lferr_2643	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Lferr_2644	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Lferr_2645	COG0842	Transport permease protein
Lferr_2646	COG0271	Belongs to the BolA IbaG family
Lferr_2647	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Lferr_2648	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Lferr_2649	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Lferr_2651	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Lferr_2652	COG0131	Imidazoleglycerol-phosphate dehydratase
Lferr_2653	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Lferr_2654	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Lferr_2655	COG0107	imidazoleglycerol-phosphate synthase activity
Lferr_2656	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Lferr_2656	COG0140	phosphoribosyl-ATP diphosphatase activity
Lferr_2657	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Lferr_2658	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Lferr_2659	COG0805	protein transport
Lferr_2660	COG1850	ribulose-bisphosphate carboxylase activity
Lferr_2666	COG0540	Belongs to the ATCase OTCase family
Lferr_2667	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Lferr_2668	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Lferr_2669	COG1678	Uncharacterized ACR, COG1678
Lferr_2670	COG0189	ligase activity
Lferr_2673	COG0316	Belongs to the HesB IscA family
Lferr_2674	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Lferr_2675	COG0508	dehydrogenase complex catalyzes the overall conversion of
Lferr_2675	COG0022	dehydrogenase e1 component
Lferr_2676	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Lferr_2679	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Lferr_2680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Lferr_2681	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Lferr_2687	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Lferr_2688	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Lferr_2690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Lferr_2691	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Lferr_2692	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Lferr_2692	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Lferr_2693	COG1611	Belongs to the LOG family
Lferr_2695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Lferr_2698	COG1555	photosystem II stabilization
Lferr_2699	COG0210	DNA helicase
Lferr_2703	COG1796	DNA polymerase
Lferr_2703	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Lferr_2706	COG1028	Short-chain dehydrogenase reductase Sdr
Lferr_2707	COG0723	plastoquinol--plastocyanin reductase activity
Lferr_2708	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Lferr_2710	COG1333	cytochrome c biogenesis protein
Lferr_2711	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Lferr_2720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Lferr_2721	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Lferr_2722	COG0175	sulfate reduction
Lferr_2724	COG2895	sulfate adenylyltransferase (ATP) activity
Lferr_2729	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Lferr_2736	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Lferr_2740	COG2814	Major facilitator Superfamily
Lferr_2741	COG0109	protoheme IX farnesyltransferase activity
Lferr_2743	COG4454	pyrroloquinoline quinone binding
Lferr_2747	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Lferr_2748	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Lferr_2755	COG0326	Molecular chaperone. Has ATPase activity
Lferr_2757	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Lferr_2760	COG1131	(ABC) transporter
Lferr_2775	COG1484	DNA-dependent DNA replication
Lferr_2776	COG4584	PFAM Integrase catalytic
Lferr_2778	COG3039	Transposase
Lferr_2785	COG1715	Restriction endonuclease
Lferr_2794	COG1196	nuclear chromosome segregation
Lferr_2805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Lferr_2808	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Lferr_2809	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Lferr_2810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Lferr_2811	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Lferr_2813	COG0356	it plays a direct role in the translocation of protons across the membrane
Lferr_2815	COG1475	DNA binding
Lferr_2816	COG1192	Involved in chromosome partitioning
Lferr_2817	COG0357	Ribosomal RNA small subunit methyltransferase G
Lferr_2818	COG0445	tRNA wobble uridine modification
Lferr_2821	COG0521	Mo-molybdopterin cofactor biosynthetic process
Lferr_2827	COG0655	NAD(P)H dehydrogenase (quinone) activity
Lferr_2837	COG1131	(ABC) transporter
Lferr_2838	COG2945	thiolester hydrolase activity
Lferr_2840	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Lferr_2841	COG1959	2 iron, 2 sulfur cluster binding
Lferr_2843	COG0134	indole-3-glycerol-phosphate synthase activity
Lferr_2844	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Lferr_2847	COG0546	phosphoglycolate phosphatase activity
Lferr_2848	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Lferr_2851	COG0126	phosphoglycerate kinase activity
Lferr_2852	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Lferr_2853	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Lferr_2854	COG1494	fructose-1,6-bisphosphatase
Lferr_2855	COG0483	inositol monophosphate 1-phosphatase activity
Lferr_2857	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Lferr_2858	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Lferr_2859	COG1322	Protein conserved in bacteria
Lferr_2860	COG1970	mechanosensitive ion channel activity
Lferr_2862	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Lferr_2863	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Lferr_2865	COG1671	Belongs to the UPF0178 family
Lferr_2872	COG0745	RESPONSE REGULATOR receiver
Lferr_2873	COG2205	protein histidine kinase activity
Lferr_2875	COG0165	Argininosuccinate lyase
Lferr_2878	COG1881	PFAM PEBP family protein
Lferr_2883	COG2181	nitrate reductase activity
Lferr_2883	COG0247	lactate metabolic process
Lferr_2885	COG0375	protein maturation
Lferr_2888	COG0409	Hydrogenase expression formation protein
Lferr_2891	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Lferr_2891	COG0662	Cupin 2, conserved barrel domain protein
Lferr_2896	COG0113	porphobilinogen synthase activity
Lferr_2898	COG0181	hydroxymethylbilane synthase activity
Lferr_2900	COG0537	adenosine 5'-monophosphoramidase activity
Lferr_2901	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Lferr_2902	COG0352	thiamine-phosphate diphosphorylase activity
Lferr_2903	COG0351	phosphomethylpyrimidine kinase