locus-tag	class	description
ANFP_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ANFP_00020	COG0592	DNA-directed DNA polymerase activity
ANFP_00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANFP_00040	COG0187	DNA topoisomerase II activity
ANFP_00050	COG0493	'glutamate synthase
ANFP_00050	COG0543	2 iron, 2 sulfur cluster binding
ANFP_00100	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ANFP_00120	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ANFP_00140	COG0850	regulation of cytokinetic process
ANFP_00160	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANFP_00180	COG2922	Belongs to the Smg family
ANFP_00190	COG0758	DNA mediated transformation
ANFP_00210	COG0242	peptide deformylase activity
ANFP_00220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ANFP_00230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ANFP_00250	COG5000	phosphorelay sensor kinase activity
ANFP_00260	COG2204	response regulator
ANFP_00290	COG3852	Histidine kinase
ANFP_00300	COG2204	response regulator
ANFP_00310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ANFP_00330	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ANFP_00340	COG0706	membrane insertase activity
ANFP_00350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ANFP_00370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ANFP_00380	COG0488	(ABC) transporter
ANFP_00400	COG1566	PFAM secretion protein HlyD family protein
ANFP_00560	COG2095	MarC family integral membrane protein
ANFP_00580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ANFP_00590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ANFP_00610	COG0217	transcriptional regulatory protein
ANFP_00620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ANFP_00630	COG0632	four-way junction helicase activity
ANFP_00640	COG2255	four-way junction helicase activity
ANFP_00650	COG0824	Thioesterase
ANFP_00690	COG0823	Involved in the tonB-independent uptake of proteins
ANFP_00700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ANFP_00710	COG0602	queuosine metabolic process
ANFP_00730	COG2885	chlorophyll binding
ANFP_00800	COG2226	methyltransferase
ANFP_00850	COG0438	transferase activity, transferring glycosyl groups
ANFP_00930	COG3177	Filamentation induced by cAMP protein fic
ANFP_00990	COG1252	NADH dehydrogenase
ANFP_01020	COG1136	(ABC) transporter
ANFP_01060	COG1914	H( )-stimulated, divalent metal cation uptake system
ANFP_01100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANFP_01110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_01210	COG2833	Protein of unknown function (DUF455)
ANFP_01220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ANFP_01240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ANFP_01250	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ANFP_01260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANFP_01270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ANFP_01330	COG1484	DNA-dependent DNA replication
ANFP_01360	COG0629	single-stranded DNA binding
ANFP_01530	COG3311	Transcriptional regulator
ANFP_01640	COG4962	Type ii secretion system protein e
ANFP_01670	COG3451	type IV secretory pathway VirB4
ANFP_01730	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ANFP_01740	COG3657	addiction module killer protein
ANFP_01760	COG3701	Conjugal transfer protein
ANFP_01910	COG1475	DNA binding
ANFP_01920	COG1192	Involved in chromosome partitioning
ANFP_01990	COG3657	addiction module killer protein
ANFP_02000	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ANFP_02030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANFP_02130	COG0583	DNA-binding transcription factor activity
ANFP_02170	COG0277	FAD linked oxidase domain protein
ANFP_02180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ANFP_02190	COG0792	nuclease activity
ANFP_02200	COG3107	peptidoglycan biosynthetic process
ANFP_02240	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ANFP_02260	COG2363	Small membrane protein
ANFP_02280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ANFP_02300	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ANFP_02310	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ANFP_02320	COG1127	ABC transporter
ANFP_02330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ANFP_02340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ANFP_02370	COG1131	(ABC) transporter
ANFP_02380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ANFP_02390	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ANFP_02410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ANFP_02440	COG0018	arginyl-trna synthetase
ANFP_02460	COG0583	DNA-binding transcription factor activity
ANFP_02480	COG0708	Exodeoxyribonuclease III
ANFP_02500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ANFP_02510	COG0625	glutathione transferase activity
ANFP_02520	COG0708	Exodeoxyribonuclease III
ANFP_02530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ANFP_02540	COG1047	Peptidyl-prolyl cis-trans
ANFP_02550	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ANFP_02560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ANFP_02570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ANFP_02600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ANFP_02610	COG0237	dephospho-CoA kinase activity
ANFP_02620	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ANFP_02630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ANFP_02650	COG0739	heme binding
ANFP_02650	COG0741	lytic transglycosylase activity
ANFP_02650	COG1196	nuclear chromosome segregation
ANFP_02660	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ANFP_02680	COG2264	protein methyltransferase activity
ANFP_02690	COG0439	Biotin carboxylase
ANFP_02710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ANFP_02740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ANFP_02760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ANFP_02770	COG1181	Belongs to the D-alanine--D-alanine ligase family
ANFP_02780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ANFP_02790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ANFP_02800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ANFP_02810	COG0772	Belongs to the SEDS family
ANFP_02820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ANFP_02830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ANFP_02840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ANFP_02850	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ANFP_02880	COG0275	rRNA processing
ANFP_02890	COG2001	Belongs to the MraZ family
ANFP_02910	COG0617	tRNA 3'-terminal CCA addition
ANFP_02920	COG1022	Amp-dependent synthetase and ligase
ANFP_02930	COG0625	glutathione transferase activity
ANFP_02940	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ANFP_02960	COG0653	protein targeting
ANFP_02970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ANFP_02980	COG0494	nUDIX hydrolase
ANFP_02990	COG0463	Glycosyl transferase, family 2
ANFP_03020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ANFP_03080	COG1519	Transferase
ANFP_03090	COG1560	Kdo2-lipid A biosynthetic process
ANFP_03100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ANFP_03110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANFP_03120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ANFP_03130	COG1040	competence protein
ANFP_03140	COG0156	8-amino-7-oxononanoate synthase activity
ANFP_03150	COG2267	carboxylic ester hydrolase activity
ANFP_03160	COG2226	methyltransferase
ANFP_03170	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ANFP_03180	COG0501	Belongs to the peptidase M48B family
ANFP_03190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ANFP_03200	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ANFP_03210	COG0390	transport system, permease component
ANFP_03230	COG0543	2 iron, 2 sulfur cluster binding
ANFP_03230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANFP_03270	COG1309	transcriptional regulator
ANFP_03280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ANFP_03290	COG1566	PFAM secretion protein HlyD family protein
ANFP_03310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ANFP_03320	COG1872	DUF167
ANFP_03420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ANFP_03430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ANFP_03440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ANFP_03450	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ANFP_03480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ANFP_03490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ANFP_03530	COG0735	belongs to the Fur family
ANFP_03540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ANFP_03550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ANFP_03560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ANFP_03570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ANFP_03580	COG0659	secondary active sulfate transmembrane transporter activity
ANFP_03590	COG0288	reversible hydration of carbon dioxide
ANFP_03600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ANFP_03610	COG2226	methyltransferase
ANFP_03630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ANFP_03630	COG2813	Specifically methylates the guanine in position
ANFP_03640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ANFP_03660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ANFP_03670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ANFP_03680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ANFP_03680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ANFP_03710	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ANFP_03720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ANFP_03760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ANFP_03780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ANFP_03810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ANFP_03820	COG0081	regulation of translation
ANFP_03830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ANFP_03840	COG0222	ribosome binding
ANFP_03850	COG0085	RNA polymerase activity
ANFP_03860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ANFP_03870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ANFP_03880	COG0049	tRNA binding
ANFP_03890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ANFP_03900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ANFP_03910	COG0051	transcription antitermination factor activity, RNA binding
ANFP_03920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ANFP_03930	COG0088	Forms part of the polypeptide exit tunnel
ANFP_03940	COG0089	rRNA binding
ANFP_03950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ANFP_03960	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ANFP_03970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ANFP_03990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ANFP_04000	COG0255	Belongs to the universal ribosomal protein uL29 family
ANFP_04010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ANFP_04020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ANFP_04030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ANFP_04040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ANFP_04050	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ANFP_04060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ANFP_04070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ANFP_04080	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ANFP_04090	COG1841	ribosomal large subunit assembly
ANFP_04100	COG0200	Binds to the 23S rRNA
ANFP_04110	COG0201	protein transport
ANFP_04120	COG0563	adenylate kinase activity
ANFP_04130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ANFP_04140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ANFP_04150	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ANFP_04160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ANFP_04170	COG0202	RNA polymerase activity
ANFP_04180	COG0203	ribosomal protein L17
ANFP_04190	COG0756	dUTP diphosphatase activity
ANFP_04200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ANFP_04210	COG2003	Belongs to the UPF0758 family
ANFP_04230	COG0671	phosphoesterase, PA-phosphatase related
ANFP_04270	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ANFP_04290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANFP_04300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ANFP_04300	COG0678	peroxiredoxin activity
ANFP_04310	COG0560	Phosphoserine phosphatase
ANFP_04320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ANFP_04330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ANFP_04340	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ANFP_04380	COG0492	ferredoxin-NADP+ reductase activity
ANFP_04400	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ANFP_04420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ANFP_04430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ANFP_04450	COG1376	ErfK ybiS ycfS ynhG family protein
ANFP_04460	COG0779	Required for maturation of 30S ribosomal subunits
ANFP_04470	COG0195	Participates in both transcription termination and antitermination
ANFP_04480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ANFP_04490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ANFP_04500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ANFP_04510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ANFP_04520	COG1185	polyribonucleotide nucleotidyltransferase activity
ANFP_04530	COG0612	Peptidase, M16
ANFP_04540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ANFP_04560	COG0328	RNA-DNA hybrid ribonuclease activity
ANFP_04570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ANFP_04590	COG0346	lactoylglutathione lyase activity
ANFP_04610	COG0137	argininosuccinate synthase activity
ANFP_04620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ANFP_04630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ANFP_04640	COG0527	aspartate kinase activity
ANFP_04750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ANFP_04770	COG0741	lytic transglycosylase activity
ANFP_04770	COG1388	LysM domain
ANFP_04780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANFP_04800	COG0538	isocitrate dehydrogenase activity
ANFP_04810	COG0045	succinate-CoA ligase (ADP-forming) activity
ANFP_04830	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ANFP_04840	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ANFP_04840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ANFP_04900	COG1850	ribulose-bisphosphate carboxylase activity
ANFP_04910	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ANFP_04920	COG0235	Class ii aldolase
ANFP_04940	COG0242	peptide deformylase activity
ANFP_04950	COG0531	amino acid
ANFP_05000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ANFP_05020	COG2204	response regulator
ANFP_05040	COG2205	protein histidine kinase activity
ANFP_05050	COG0497	DNA recombination
ANFP_05060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ANFP_05070	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ANFP_05080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ANFP_05080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ANFP_05090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ANFP_05110	COG1466	dna polymerase III delta subunit
ANFP_05130	COG0495	leucyl-tRNA aminoacylation
ANFP_05140	COG0655	NAD(P)H dehydrogenase (quinone) activity
ANFP_05150	COG2353	YceI-like domain
ANFP_05160	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ANFP_05170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ANFP_05220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ANFP_05230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ANFP_05260	COG0436	Aminotransferase
ANFP_05280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ANFP_05300	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ANFP_05310	COG4456	Virulence-associated protein
ANFP_05320	COG1487	ribonuclease activity
ANFP_05330	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ANFP_05340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ANFP_05360	COG1136	(ABC) transporter
ANFP_05380	COG0658	competence protein
ANFP_05380	COG2333	competence protein COMEC
ANFP_05390	COG0811	peptide transport
ANFP_05400	COG0848	biopolymer transport protein
ANFP_05430	COG1663	tetraacyldisaccharide 4'-kinase activity
ANFP_05440	COG2835	tetraacyldisaccharide 4'-kinase activity
ANFP_05450	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ANFP_05500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ANFP_05510	COG0667	Aldo Keto reductase
ANFP_05570	COG2329	Antibiotic biosynthesis monooxygenase
ANFP_05620	COG3409	Peptidoglycan-binding domain 1 protein
ANFP_05620	COG3267	Type II secretory pathway component ExeA
ANFP_05700	COG1573	uracil-dna glycosylase
ANFP_05710	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ANFP_05720	COG0542	response to heat
ANFP_05730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ANFP_05740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANFP_05750	COG0693	protein deglycase activity
ANFP_05760	COG0793	Belongs to the peptidase S41A family
ANFP_05780	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ANFP_05790	COG0058	SHG alpha-glucan phosphorylase activity
ANFP_05810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANFP_05820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ANFP_05840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ANFP_05850	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ANFP_05900	COG2046	Belongs to the sulfate adenylyltransferase family
ANFP_05900	COG0529	Catalyzes the synthesis of activated sulfate
ANFP_05920	COG0459	protein refolding
ANFP_05930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ANFP_05990	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ANFP_06010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ANFP_06050	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ANFP_06060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ANFP_06070	COG0196	riboflavin kinase activity
ANFP_06130	COG1561	YicC-like family, N-terminal region
ANFP_06140	COG0194	GDP metabolic process
ANFP_06150	COG1758	RNA polymerase activity
ANFP_06160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ANFP_06220	COG0628	permease
ANFP_06230	COG1355	regulation of microtubule-based process
ANFP_06240	COG2078	PFAM AMMECR1 domain protein
ANFP_06260	COG1538	Outer membrane efflux protein
ANFP_06320	COG0776	regulation of translation
ANFP_06330	COG0393	Putative heavy-metal-binding
ANFP_06350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ANFP_06360	COG0732	type I restriction modification DNA specificity domain
ANFP_06370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ANFP_06430	COG0776	regulation of translation
ANFP_06750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANFP_06750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANFP_06810	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
ANFP_06890	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ANFP_06970	COG4962	Type ii secretion system protein e
ANFP_07010	COG3451	type IV secretory pathway VirB4
ANFP_07090	COG2948	multi-organism process
ANFP_07190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANFP_07220	COG1192	Involved in chromosome partitioning
ANFP_07230	COG1475	DNA binding
ANFP_07450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANFP_07470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ANFP_07510	COG0393	Putative heavy-metal-binding
ANFP_07520	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ANFP_07630	COG0513	Belongs to the DEAD box helicase family
ANFP_07640	COG1278	Cold shock
ANFP_07650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ANFP_07660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ANFP_07680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ANFP_07700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANFP_07710	COG1702	phosphate starvation-inducible protein PhoH
ANFP_07720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ANFP_07740	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ANFP_07750	COG0312	modulator of DNA gyrase
ANFP_07770	COG1121	(ABC) transporter
ANFP_07790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ANFP_07870	COG0438	transferase activity, transferring glycosyl groups
ANFP_07880	COG0438	transferase activity, transferring glycosyl groups
ANFP_07890	COG1132	(ABC) transporter
ANFP_07900	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ANFP_07950	COG2226	methyltransferase
ANFP_07960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ANFP_07970	COG0066	3-isopropylmalate dehydratase activity
ANFP_07990	COG0259	pyridoxamine-phosphate oxidase activity
ANFP_08000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ANFP_08020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ANFP_08030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ANFP_08060	COG0109	protoheme IX farnesyltransferase activity
ANFP_08070	COG2814	Major facilitator Superfamily
ANFP_08080	COG1968	undecaprenyl-diphosphatase activity
ANFP_08090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ANFP_08110	COG0505	Belongs to the CarA family
ANFP_08140	COG2022	thiamine diphosphate biosynthetic process
ANFP_08160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ANFP_08170	COG0163	prenyltransferase activity
ANFP_08180	COG1127	ABC transporter
ANFP_08190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ANFP_08230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ANFP_08250	COG0577	efflux transmembrane transporter activity
ANFP_08260	COG1136	(ABC) transporter
ANFP_08290	COG0254	rRNA binding
ANFP_08300	COG0281	malic enzyme
ANFP_08310	COG0628	permease
ANFP_08320	COG0129	dihydroxy-acid dehydratase activity
ANFP_08340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ANFP_08340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ANFP_08350	COG0271	Belongs to the BolA IbaG family
ANFP_08360	COG2350	Protein conserved in bacteria
ANFP_08370	COG2917	probably involved in intracellular septation
ANFP_08400	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ANFP_08420	COG1959	2 iron, 2 sulfur cluster binding
ANFP_08430	COG1104	cysteine desulfurase activity
ANFP_08440	COG0822	iron-sulfur transferase activity
ANFP_08460	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ANFP_08470	COG0443	Heat shock 70 kDa protein
ANFP_08500	COG0482	sulfurtransferase activity
ANFP_08510	COG1752	Esterase of the alpha-beta hydrolase superfamily
ANFP_08550	COG0732	type I restriction modification DNA specificity domain
ANFP_08600	COG4372	Transposase
ANFP_08620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ANFP_08650	COG3284	Transcriptional regulator
ANFP_08670	COG3791	Glutathione-dependent formaldehyde-activating
ANFP_08680	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ANFP_08690	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ANFP_08700	COG0583	DNA-binding transcription factor activity
ANFP_08710	COG2204	response regulator
ANFP_08810	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ANFP_08840	COG0298	carbon dioxide binding
ANFP_08850	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ANFP_08880	COG0375	protein maturation
ANFP_08930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ANFP_08990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ANFP_09000	COG0493	'glutamate synthase
ANFP_09010	COG0070	glutamate synthase
ANFP_09010	COG0067	glutamate synthase
ANFP_09010	COG0069	glutamate synthase activity
ANFP_09020	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ANFP_09030	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ANFP_09040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ANFP_09050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ANFP_09120	COG0432	Pfam Uncharacterised protein family UPF0047
ANFP_09140	COG1193	negative regulation of DNA recombination
ANFP_09150	COG0028	Belongs to the TPP enzyme family
ANFP_09170	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ANFP_09180	COG0688	phosphatidylethanolamine metabolic process
ANFP_09190	COG1183	phosphatidylcholine synthase activity
ANFP_09210	COG0589	response to stress
ANFP_09220	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ANFP_09230	COG1196	nuclear chromosome segregation
ANFP_09260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ANFP_09330	COG0730	response to heat
ANFP_09350	COG0811	peptide transport
ANFP_09400	COG0402	S-adenosylhomocysteine deaminase activity
ANFP_09410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ANFP_09500	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ANFP_09500	COG3608	succinylglutamate desuccinylase aspartoacylase
ANFP_09610	COG0475	glutathione-regulated potassium exporter activity
ANFP_09620	COG1028	Short-chain dehydrogenase reductase Sdr
ANFP_09790	COG2080	2 iron, 2 sulfur cluster binding
ANFP_09790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ANFP_09820	COG2814	Major facilitator Superfamily
ANFP_09830	COG0038	chloride channel
ANFP_09850	COG0583	DNA-binding transcription factor activity
ANFP_09950	COG1196	nuclear chromosome segregation
ANFP_09960	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ANFP_10010	COG1484	DNA-dependent DNA replication
ANFP_10040	COG4584	PFAM Integrase catalytic
ANFP_10090	COG3344	reverse transcriptase
ANFP_10110	COG2801	Transposase and inactivated derivatives
ANFP_10200	COG0420	3'-5' exonuclease activity
ANFP_10210	COG0419	ATPase involved in DNA repair
ANFP_10380	COG2217	Heavy metal translocating P-type atpase
ANFP_10390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ANFP_10430	COG0789	Transcriptional regulator
ANFP_10480	COG2608	mercury ion transmembrane transporter activity
ANFP_10500	COG0789	Transcriptional regulator
ANFP_10640	COG2995	paraquat-inducible protein a
ANFP_10660	COG0531	amino acid
ANFP_10670	COG0076	glutamate decarboxylase activity
ANFP_10680	COG1484	DNA-dependent DNA replication
ANFP_10740	COG2814	Major facilitator Superfamily
ANFP_10750	COG2801	Transposase and inactivated derivatives
ANFP_10770	COG4584	PFAM Integrase catalytic
ANFP_10780	COG1484	DNA-dependent DNA replication
ANFP_10800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ANFP_10900	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_10990	COG1230	cation diffusion facilitator family transporter
ANFP_11000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ANFP_11000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANFP_11020	COG0477	Major facilitator Superfamily
ANFP_11370	COG0640	Transcriptional regulator
ANFP_11380	COG0697	spore germination
ANFP_11540	COG1064	alcohol dehydrogenase
ANFP_11550	COG0504	CTP synthase activity
ANFP_11560	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ANFP_11570	COG0148	phosphopyruvate hydratase activity
ANFP_11580	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ANFP_11590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ANFP_11610	COG0322	excinuclease ABC activity
ANFP_11640	COG3189	MarR family transcriptional regulator
ANFP_11670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANFP_11670	COG1017	nitric oxide dioxygenase activity
ANFP_11680	COG1566	PFAM secretion protein HlyD family protein
ANFP_11690	COG1538	Outer membrane efflux protein
ANFP_11700	COG2814	Major facilitator Superfamily
ANFP_11710	COG0583	DNA-binding transcription factor activity
ANFP_11760	COG2161	toxin-antitoxin pair type II binding
ANFP_11790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANFP_11810	COG0384	phenazine biosynthesis protein PhzF
ANFP_11840	COG1247	-acetyltransferase
ANFP_11880	COG0300	oxidoreductase activity
ANFP_11930	COG0393	Putative heavy-metal-binding
ANFP_11950	COG2026	Addiction module toxin, RelE StbE family
ANFP_11960	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ANFP_11970	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ANFP_11990	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ANFP_12000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ANFP_12020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ANFP_12030	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ANFP_12040	COG0287	Prephenate dehydrogenase
ANFP_12060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ANFP_12070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ANFP_12090	COG0776	regulation of translation
ANFP_12100	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ANFP_12110	COG0284	orotidine-5'-phosphate decarboxylase activity
ANFP_12120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ANFP_12130	COG0544	peptidyl-prolyl cis-trans isomerase activity
ANFP_12150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ANFP_12160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANFP_12180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANFP_12190	COG0671	phosphoesterase, PA-phosphatase related
ANFP_12250	COG2915	High frequency lysogenization protein hflD homolog
ANFP_12260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ANFP_12270	COG0024	Methionine aminopeptidase
ANFP_12280	COG1489	DNA binding
ANFP_12290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANFP_12310	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ANFP_12320	COG1546	Belongs to the CinA family
ANFP_12320	COG1058	Belongs to the CinA family
ANFP_12330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ANFP_12340	COG2137	regulation of response to DNA damage stimulus
ANFP_12420	COG1196	nuclear chromosome segregation
ANFP_12420	COG0741	lytic transglycosylase activity
ANFP_12420	COG0739	heme binding
ANFP_12430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANFP_12460	COG0488	(ABC) transporter
ANFP_12480	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ANFP_12530	COG1294	oxidase, subunit
ANFP_12580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANFP_12610	COG2943	transferase activity, transferring hexosyl groups
ANFP_12610	COG3416	Protein conserved in bacteria
ANFP_12630	COG2363	Small membrane protein
ANFP_12720	COG0616	signal peptide processing
ANFP_12730	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ANFP_12740	COG0314	molybdopterin synthase activity
ANFP_12750	COG1666	GTP binding
ANFP_12770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ANFP_12780	COG0509	glycine decarboxylation via glycine cleavage system
ANFP_12790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ANFP_12800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ANFP_12810	COG1132	(ABC) transporter
ANFP_12820	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANFP_12830	COG0450	alkyl hydroperoxide reductase
ANFP_12850	COG0613	PHP domain protein
ANFP_12860	COG0628	permease
ANFP_12900	COG0084	hydrolase, TatD family'
ANFP_12910	COG0321	lipoyl(octanoyl) transferase activity
ANFP_12910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ANFP_12930	COG0776	regulation of translation
ANFP_13020	COG3846	protein secretion by the type IV secretion system
ANFP_13090	COG0393	Putative heavy-metal-binding
ANFP_13140	COG3451	type IV secretory pathway VirB4
ANFP_13150	COG5268	conjugation
ANFP_13180	COG4962	Type ii secretion system protein e
ANFP_13410	COG0776	regulation of translation
ANFP_13440	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ANFP_13480	COG1215	transferase activity, transferring glycosyl groups
ANFP_13700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANFP_13750	COG0210	DNA helicase
ANFP_13790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANFP_13790	COG1754	DNA topoisomerase type I activity
ANFP_14010	COG1285	pathogenesis
ANFP_14020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANFP_14090	COG4680	protein conserved in bacteria
ANFP_14140	COG4988	ABC transporter
ANFP_14150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ANFP_14170	COG0354	folic acid binding
ANFP_14190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ANFP_14220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANFP_14230	COG0481	GTPase activity
ANFP_14240	COG0681	Belongs to the peptidase S26 family
ANFP_14260	COG0571	ribonuclease III activity
ANFP_14270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ANFP_14280	COG1381	Involved in DNA repair and RecF pathway recombination
ANFP_14290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ANFP_14300	COG0736	holo-[acyl-carrier-protein] synthase activity
ANFP_14320	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ANFP_14320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ANFP_14330	COG0037	tRNA processing
ANFP_14340	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ANFP_14460	COG0438	transferase activity, transferring glycosyl groups
ANFP_14500	COG1230	cation diffusion facilitator family transporter
ANFP_14530	COG0513	Belongs to the DEAD box helicase family
ANFP_14560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANFP_14570	COG0573	inorganic phosphate transmembrane transporter activity
ANFP_14580	COG0581	inorganic phosphate transmembrane transporter activity
ANFP_14590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ANFP_14600	COG0704	Plays a role in the regulation of phosphate uptake
ANFP_14630	COG0052	Belongs to the universal ribosomal protein uS2 family
ANFP_14640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ANFP_14650	COG0528	UMP kinase activity
ANFP_14670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ANFP_14680	COG0575	Belongs to the CDS family
ANFP_14690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ANFP_14730	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANFP_14740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ANFP_14750	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANFP_14760	COG0673	inositol 2-dehydrogenase activity
ANFP_14780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANFP_14790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ANFP_14810	COG0825	malonyl-CoA metabolic process
ANFP_14820	COG0037	tRNA processing
ANFP_14840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ANFP_14850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ANFP_14870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ANFP_14880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ANFP_14890	COG1166	arginine decarboxylase activity
ANFP_14980	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ANFP_15040	COG0811	peptide transport
ANFP_15090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ANFP_15100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ANFP_15110	COG1120	ATPase activity
ANFP_15130	COG0725	ABC transporter, periplasmic molybdate-binding protein
ANFP_15150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ANFP_15180	COG0725	ABC transporter, periplasmic molybdate-binding protein
ANFP_15220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANFP_15330	COG5420	small protein containing a coiled-coil domain
ANFP_15360	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANFP_15370	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANFP_15400	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANFP_15420	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
ANFP_15480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ANFP_15550	COG1104	cysteine desulfurase activity
ANFP_15560	COG5554	nitrogen fixation
ANFP_15580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ANFP_15590	COG0633	Ferredoxin
ANFP_15640	COG1012	belongs to the aldehyde dehydrogenase family
ANFP_15680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ANFP_15690	COG0438	transferase activity, transferring glycosyl groups
ANFP_15700	COG0438	transferase activity, transferring glycosyl groups
ANFP_15710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ANFP_15750	COG1666	GTP binding
ANFP_15760	COG0438	transferase activity, transferring glycosyl groups
ANFP_15770	COG0670	Belongs to the BI1 family
ANFP_15820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ANFP_15830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ANFP_15840	COG1428	Deoxynucleoside kinase
ANFP_15860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ANFP_15860	COG3620	sequence-specific DNA binding
ANFP_15860	COG0617	tRNA 3'-terminal CCA addition
ANFP_15880	COG0463	Glycosyl transferase, family 2
ANFP_15910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ANFP_15910	COG0519	Catalyzes the synthesis of GMP from XMP
ANFP_15920	COG4691	Plasmid stability protein
ANFP_15930	COG1487	ribonuclease activity
ANFP_15960	COG0531	amino acid
ANFP_15970	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ANFP_15980	COG3264	Mechanosensitive ion channel
ANFP_15980	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ANFP_16010	COG0009	L-threonylcarbamoyladenylate synthase
ANFP_16020	COG1994	Peptidase M50
ANFP_16030	COG0180	Tryptophanyl-tRNA synthetase
ANFP_16040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ANFP_16050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ANFP_16060	COG0446	pyridine nucleotide-disulphide oxidoreductase
ANFP_16070	COG1187	pseudouridine synthase activity
ANFP_16110	COG2814	Major facilitator Superfamily
ANFP_16140	COG0148	phosphopyruvate hydratase activity
ANFP_16190	COG1105	Belongs to the carbohydrate kinase PfkB family
ANFP_16200	COG0280	phosphate acetyltransferase
ANFP_16210	COG0477	Major facilitator Superfamily
ANFP_16220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ANFP_16230	COG0508	dehydrogenase complex catalyzes the overall conversion of
ANFP_16240	COG0022	dehydrogenase e1 component
ANFP_16250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ANFP_16270	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ANFP_16280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ANFP_16280	COG0574	Belongs to the PEP-utilizing enzyme family
ANFP_16310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ANFP_16320	COG2171	N-acyltransferase activity
ANFP_16360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ANFP_16370	COG0402	S-adenosylhomocysteine deaminase activity
ANFP_16390	COG1388	LysM domain
ANFP_16390	COG0791	NLP P60 protein
ANFP_16430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANFP_16460	COG1484	DNA-dependent DNA replication
ANFP_16470	COG4584	PFAM Integrase catalytic
ANFP_16530	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANFP_16570	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ANFP_16590	COG1216	Glycosyl transferase, family 2
ANFP_16640	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ANFP_16650	COG1028	Short-chain dehydrogenase reductase Sdr
ANFP_16670	COG2154	pterin-4-alpha-carbinolamine dehydratase
ANFP_16730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ANFP_16760	COG0587	DNA-directed DNA polymerase activity
ANFP_16780	COG0308	aminopeptidase N
ANFP_16820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ANFP_16830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_16870	COG0424	maF-like protein
ANFP_16880	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ANFP_16890	COG1923	regulation of RNA biosynthetic process
ANFP_16900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ANFP_16910	COG0330	HflC and HflK could
ANFP_16920	COG0330	HflC and HflK could
ANFP_16930	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ANFP_16970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANFP_16980	COG1058	Belongs to the CinA family
ANFP_16980	COG1546	Belongs to the CinA family
ANFP_17000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ANFP_17010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ANFP_17030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ANFP_17040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ANFP_17060	COG1295	ribonuclease BN
ANFP_17100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ANFP_17110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ANFP_17130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ANFP_17140	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ANFP_17150	COG1295	ribonuclease BN
ANFP_17170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ANFP_17180	COG0416	fatty acid biosynthetic process
ANFP_17190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ANFP_17200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ANFP_17220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANFP_17230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ANFP_17250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ANFP_17260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ANFP_17300	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ANFP_17310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ANFP_17320	COG0004	ammonium transporteR
ANFP_17330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ANFP_17330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ANFP_17340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ANFP_17360	COG0802	atpase or kinase
ANFP_17370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ANFP_17380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ANFP_17390	COG0105	UTP biosynthetic process
ANFP_17400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ANFP_17430	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ANFP_17440	COG0124	histidyl-tRNA synthetase
ANFP_17470	COG1160	GTP binding
ANFP_17560	COG0730	response to heat
ANFP_17570	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_17600	COG1881	PFAM PEBP family protein
ANFP_17620	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANFP_17660	COG0729	surface antigen
ANFP_17700	COG4654	Cytochrome c, class I
ANFP_17770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANFP_17790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ANFP_17810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ANFP_17840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ANFP_17850	COG1469	GTP cyclohydrolase I activity
ANFP_17860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ANFP_17870	COG0142	geranyltranstransferase activity
ANFP_17890	COG2223	nitrite transmembrane transporter activity
ANFP_17910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ANFP_17920	COG1570	exodeoxyribonuclease VII activity
ANFP_17930	COG2010	Cytochrome c
ANFP_17930	COG4993	Dehydrogenase
ANFP_17980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ANFP_17990	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANFP_18000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ANFP_18010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANFP_18060	COG0583	DNA-binding transcription factor activity
ANFP_18070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ANFP_18080	COG2197	response regulator
ANFP_18100	COG3916	Acyl-homoserine-lactone synthase
ANFP_18240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ANFP_18250	COG0456	acetyltransferase
ANFP_18300	COG2217	Heavy metal translocating P-type atpase
ANFP_18310	COG0436	Aminotransferase
ANFP_18330	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ANFP_18340	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ANFP_18350	COG0640	Transcriptional regulator
ANFP_18360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ANFP_18380	COG0187	DNA topoisomerase II activity
ANFP_18390	COG0642	Histidine kinase
ANFP_18560	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ANFP_18590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ANFP_18600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ANFP_18610	COG1862	Preprotein translocase
ANFP_18620	COG0343	queuine tRNA-ribosyltransferase activity
ANFP_18630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ANFP_18640	COG1253	flavin adenine dinucleotide binding
ANFP_18670	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ANFP_18690	COG0285	dihydrofolate synthase activity
ANFP_18700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ANFP_18710	COG0159	tryptophan synthase activity
ANFP_18720	COG0133	tryptophan synthase activity
ANFP_18730	COG0135	phosphoribosylanthranilate isomerase activity
ANFP_18740	COG0101	tRNA pseudouridine synthase activity
ANFP_18760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ANFP_18780	COG0746	molybdenum cofactor guanylyltransferase activity
ANFP_18790	COG1763	Mo-molybdopterin cofactor biosynthetic process
ANFP_18800	COG0303	'Molybdopterin
ANFP_18810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ANFP_18820	COG0616	signal peptide processing
ANFP_18850	COG0438	transferase activity, transferring glycosyl groups
ANFP_18910	COG0501	Belongs to the peptidase M48B family
ANFP_18920	COG0477	Major facilitator Superfamily
ANFP_19040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANFP_19050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_19090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ANFP_19100	COG0154	amidase activity
ANFP_19110	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ANFP_19180	COG3394	polysaccharide catabolic process
ANFP_19210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANFP_19220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ANFP_19230	COG1657	PFAM Prenyltransferase squalene oxidase
ANFP_19240	COG1562	ergosterol biosynthetic process
ANFP_19250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ANFP_19260	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ANFP_19300	COG0442	prolyl-tRNA aminoacylation
ANFP_19340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ANFP_19370	COG1692	metallophosphoesterase
ANFP_19380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ANFP_19410	COG0768	penicillin binding
ANFP_19420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ANFP_19430	COG0193	aminoacyl-tRNA hydrolase activity
ANFP_19440	COG0012	GTP binding
ANFP_19460	COG0651	ATP synthesis coupled electron transport
ANFP_19470	COG0650	Formate hydrogenlyase subunit 4
ANFP_19490	COG0651	ATP synthesis coupled electron transport
ANFP_19500	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ANFP_19500	COG3261	NADH dehydrogenase
ANFP_19510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANFP_19520	COG1850	ribulose-bisphosphate carboxylase activity
ANFP_19560	COG2824	Alkylphosphonate utilization operon protein PhnA
ANFP_19570	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ANFP_19660	COG0726	polysaccharide deacetylase
ANFP_19660	COG1649	PFAM Uncharacterised BCR, COG1649
ANFP_19680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ANFP_19690	COG0494	nUDIX hydrolase
ANFP_19710	COG1187	pseudouridine synthase activity
ANFP_19720	COG2957	Belongs to the agmatine deiminase family
ANFP_19730	COG0243	molybdopterin cofactor binding
ANFP_19790	COG0589	response to stress
ANFP_19800	COG2814	Major facilitator Superfamily
ANFP_19830	COG0210	DNA helicase
ANFP_19840	COG0268	Binds directly to 16S ribosomal RNA
ANFP_19850	COG3842	ATPase activity
ANFP_19880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ANFP_19890	COG0514	ATP-dependent DNA helicase (RecQ)
ANFP_19900	COG1965	Belongs to the frataxin family
ANFP_19940	COG0795	lipopolysaccharide-transporting ATPase activity
ANFP_19950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ANFP_19980	COG0525	valine-tRNA ligase activity
ANFP_19990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ANFP_20030	COG0412	Dienelactone hydrolase
ANFP_20040	COG1902	pentaerythritol trinitrate reductase activity
ANFP_20060	COG3152	Membrane
ANFP_20120	COG1530	ribonuclease E activity
ANFP_20130	COG0215	cysteine-tRNA ligase activity
ANFP_20140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANFP_20170	COG1028	Short-chain dehydrogenase reductase Sdr
ANFP_20210	COG0745	RESPONSE REGULATOR receiver
ANFP_20220	COG2205	protein histidine kinase activity
ANFP_20230	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ANFP_20240	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ANFP_20250	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ANFP_20270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ANFP_20370	COG4953	penicillin-binding protein 1C
ANFP_20430	COG0138	bifunctional purine biosynthesis protein purh
ANFP_20440	COG0151	Belongs to the GarS family
ANFP_20450	COG0009	L-threonylcarbamoyladenylate synthase
ANFP_20460	COG0408	coproporphyrinogen oxidase activity
ANFP_20470	COG0167	dihydroorotate dehydrogenase activity
ANFP_20530	COG0811	peptide transport
ANFP_20560	COG0811	peptide transport
ANFP_20600	COG0477	Major facilitator Superfamily
ANFP_20610	COG3624	Phosphonate C-P lyase system protein PhnG
ANFP_20620	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ANFP_20630	COG3626	phosphonate metabolism
ANFP_20640	COG3627	carbon phosphorus lyase activity
ANFP_20650	COG4107	phosphonate C-P lyase system protein PhnK
ANFP_20660	COG4778	phosphonate C-P lyase system protein PhnL
ANFP_20670	COG3454	Phosphonate metabolism
ANFP_20690	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ANFP_20700	COG2188	Transcriptional regulator
ANFP_20740	COG1131	(ABC) transporter
ANFP_20770	COG3511	phospholipase C
ANFP_20790	COG0811	peptide transport
ANFP_20820	COG4774	siderophore transport
ANFP_20900	COG2814	Major facilitator Superfamily
ANFP_20920	COG2062	phosphohistidine phosphatase, SixA
ANFP_20960	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ANFP_20970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ANFP_21000	COG0033	Phosphoglucomutase
ANFP_21030	COG3038	cytochrome b561
ANFP_21050	COG2814	Major facilitator Superfamily
ANFP_21060	COG0583	DNA-binding transcription factor activity
ANFP_21090	COG1193	negative regulation of DNA recombination
ANFP_21110	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ANFP_21130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ANFP_21140	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ANFP_21170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ANFP_21220	COG1686	Belongs to the peptidase S11 family
ANFP_21350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANFP_21400	COG1196	nuclear chromosome segregation
ANFP_21450	COG2259	Doxx family
ANFP_21470	COG0655	NAD(P)H dehydrogenase (quinone) activity
ANFP_21480	COG1733	regulation of RNA biosynthetic process
ANFP_21540	COG1846	Transcriptional regulator
ANFP_21560	COG2353	YceI-like domain
ANFP_21610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ANFP_21660	COG0625	glutathione transferase activity
ANFP_21690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANFP_21700	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ANFP_21800	COG0667	Aldo Keto reductase
ANFP_21830	COG1192	Involved in chromosome partitioning
ANFP_21840	COG1475	DNA binding
ANFP_21930	COG3300	MHYT domain
ANFP_21930	COG5001	Diguanylate cyclase
ANFP_22060	COG3701	Conjugal transfer protein
ANFP_22090	COG1850	ribulose-bisphosphate carboxylase activity
ANFP_22150	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANFP_22160	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANFP_22170	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANFP_22200	COG1192	Involved in chromosome partitioning
ANFP_22240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ANFP_22250	COG0009	L-threonylcarbamoyladenylate synthase
ANFP_22260	COG0129	dihydroxy-acid dehydratase activity
ANFP_22270	COG0418	dihydroorotase activity
ANFP_22340	COG0277	FAD linked oxidase domain protein
ANFP_22350	COG0277	FAD linked oxidase domain protein
ANFP_22360	COG0247	lactate metabolic process
ANFP_22370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ANFP_22380	COG3002	Belongs to the UPF0753 family
ANFP_22410	COG1151	hydroxylamine reductase activity
ANFP_22420	COG0633	Ferredoxin
ANFP_22420	COG0543	2 iron, 2 sulfur cluster binding
ANFP_22440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ANFP_22460	COG0243	molybdopterin cofactor binding
ANFP_22470	COG2084	Dehydrogenase
ANFP_22510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANFP_22570	COG3451	type IV secretory pathway VirB4
ANFP_22620	COG4962	Type ii secretion system protein e
ANFP_22650	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ANFP_22660	COG3657	addiction module killer protein
ANFP_22700	COG4372	Transposase
ANFP_22890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ANFP_22980	COG3077	Addiction module antitoxin, RelB DinJ family
ANFP_23020	COG0776	regulation of translation
ANFP_23030	COG0776	regulation of translation
ANFP_23090	COG1002	Type II restriction enzyme, methylase subunits
ANFP_23110	COG1061	Type III restriction enzyme res subunit
ANFP_23120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANFP_23130	COG0028	Belongs to the TPP enzyme family
ANFP_23170	COG0328	RNA-DNA hybrid ribonuclease activity
ANFP_23260	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ANFP_23460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANFP_23470	COG0393	Putative heavy-metal-binding
ANFP_23530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ANFP_23550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANFP_23720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ANFP_23730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ANFP_23750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ANFP_23760	COG1272	protein, Hemolysin III
ANFP_23770	COG0860	N-Acetylmuramoyl-L-alanine amidase
ANFP_23790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ANFP_23800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANFP_23820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_23830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANFP_23850	COG0640	Transcriptional regulator
ANFP_23940	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ANFP_23950	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ANFP_23980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ANFP_24000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ANFP_24010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ANFP_24080	COG3344	reverse transcriptase
ANFP_24090	COG3344	reverse transcriptase
ANFP_24120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ANFP_24130	COG4974	Belongs to the 'phage' integrase family
ANFP_24230	COG0454	-acetyltransferase
ANFP_24240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANFP_24400	COG4372	Transposase
ANFP_24430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ANFP_24450	COG1484	DNA-dependent DNA replication
ANFP_24460	COG5001	Diguanylate cyclase
ANFP_24520	COG1846	Transcriptional regulator
ANFP_24540	COG2353	YceI-like domain
ANFP_24600	COG0776	regulation of translation
ANFP_24610	COG0776	regulation of translation
ANFP_24650	COG0477	Major facilitator Superfamily
ANFP_24680	COG0811	peptide transport
ANFP_24770	COG4372	Transposase
ANFP_24810	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ANFP_24820	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ANFP_24830	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ANFP_24840	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ANFP_24890	COG0789	Transcriptional regulator
ANFP_25010	COG1484	DNA-dependent DNA replication
ANFP_25020	COG4584	PFAM Integrase catalytic
ANFP_25170	COG0789	Transcriptional regulator
ANFP_25230	COG1199	ATP-dependent helicase activity
ANFP_25250	COG0791	NLP P60 protein
ANFP_25290	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ANFP_25320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ANFP_25330	COG0586	Pfam SNARE associated Golgi protein
ANFP_25360	COG0583	DNA-binding transcription factor activity
ANFP_25390	COG0123	including yeast histone deacetylase and acetoin utilization protein
ANFP_25490	COG0644	oxidoreductase
ANFP_25500	COG0095	Lipoate-protein ligase
ANFP_25520	COG0509	glycine decarboxylation via glycine cleavage system
ANFP_25540	COG0509	glycine decarboxylation via glycine cleavage system
ANFP_25550	COG2048	Heterodisulfide reductase, subunit B
ANFP_25610	COG2210	Belongs to the sulfur carrier protein TusA family
ANFP_25620	COG0425	Belongs to the sulfur carrier protein TusA family
ANFP_25630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANFP_25640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ANFP_25660	COG0315	cyclic pyranopterin monophosphate synthase activity
ANFP_25670	COG1077	Cell shape determining protein MreB Mrl
ANFP_25680	COG1792	Involved in formation and maintenance of cell shape
ANFP_25700	COG0768	penicillin binding
ANFP_25710	COG0772	Belongs to the SEDS family
ANFP_25720	COG1686	Belongs to the peptidase S11 family
ANFP_25740	COG0321	lipoyl(octanoyl) transferase activity
ANFP_25750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ANFP_25850	COG0751	glycine-tRNA ligase activity
ANFP_25860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ANFP_25880	COG0189	ligase activity
ANFP_25920	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ANFP_25980	COG0625	glutathione transferase activity
ANFP_25990	COG1733	regulation of RNA biosynthetic process
ANFP_26000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANFP_26090	COG1131	(ABC) transporter
ANFP_26130	COG0776	regulation of translation
ANFP_26140	COG0072	phenylalanine-tRNA ligase activity
ANFP_26140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANFP_26150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ANFP_26160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ANFP_26170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ANFP_26180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ANFP_26190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ANFP_26200	COG1007	ATP synthesis coupled electron transport
ANFP_26230	COG0713	ATP synthesis coupled electron transport
ANFP_26250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANFP_26260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ANFP_26270	COG1034	ATP synthesis coupled electron transport
ANFP_26290	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ANFP_26300	COG0649	NAD binding
ANFP_26310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANFP_26320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANFP_26330	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANFP_26340	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ANFP_26350	COG0149	triose-phosphate isomerase activity
ANFP_26360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ANFP_26370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ANFP_26380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANFP_26390	COG0312	modulator of DNA gyrase
ANFP_26400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ANFP_26400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ANFP_26410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ANFP_26440	COG0477	Major facilitator Superfamily
ANFP_26530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ANFP_26590	COG0717	Belongs to the dCTP deaminase family
ANFP_26600	COG0489	protein tyrosine kinase activity
ANFP_26620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ANFP_26630	COG0484	heat shock protein binding
ANFP_26640	COG0443	Heat shock 70 kDa protein
ANFP_26650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ANFP_26660	COG1420	regulation of RNA biosynthetic process
ANFP_26670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ANFP_26680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ANFP_26690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANFP_26690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANFP_26700	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ANFP_26710	COG0114	fumarate hydratase activity
ANFP_26760	COG0297	glycogen (starch) synthase activity
ANFP_26770	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ANFP_26790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ANFP_26890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANFP_26920	COG2204	response regulator
ANFP_26920	COG5564	TIM-barrel signal transduction protein
ANFP_26940	COG2204	response regulator
ANFP_27020	COG4964	Belongs to the GSP D family
ANFP_27120	COG0457	Tetratricopeptide repeat
ANFP_27180	COG0826	peptidase U32
ANFP_27190	COG0826	peptidase U32
ANFP_27200	COG3154	lipid carrier protein
ANFP_27230	COG1028	Short-chain dehydrogenase reductase Sdr
ANFP_27240	COG0723	plastoquinol--plastocyanin reductase activity
ANFP_27250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ANFP_27260	COG2857	Cytochrome c1
ANFP_27300	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ANFP_27310	COG1534	Rna-binding protein
ANFP_27320	COG2967	ApaG domain
ANFP_27330	COG2226	methyltransferase
ANFP_27360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ANFP_27390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ANFP_27410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ANFP_27450	COG2177	Part of the ABC transporter FtsEX involved in
ANFP_27460	COG2884	Cell division ATP-binding protein ftsE
ANFP_27470	COG0552	protein localization to endoplasmic reticulum
ANFP_27480	COG0742	ribosomal rna small subunit methyltransferase
ANFP_27490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ANFP_27500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ANFP_27510	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ANFP_27520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ANFP_27530	COG2890	protein-(glutamine-N5) methyltransferase activity
ANFP_27540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ANFP_27550	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ANFP_27570	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ANFP_27580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ANFP_27590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ANFP_27640	COG1487	ribonuclease activity
ANFP_27670	COG0625	glutathione transferase activity
ANFP_27710	COG1484	DNA-dependent DNA replication
ANFP_27720	COG4584	PFAM Integrase catalytic
ANFP_27820	COG0393	Putative heavy-metal-binding
ANFP_27840	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ANFP_27860	COG0732	type I restriction modification DNA specificity domain
ANFP_27890	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ANFP_27930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ANFP_28060	COG0006	proline dipeptidase activity
ANFP_28090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ANFP_28100	COG0305	Participates in initiation and elongation during chromosome replication
ANFP_28110	COG0359	binds to the 23S rRNA
ANFP_28140	COG0360	Binds together with S18 to 16S ribosomal RNA
ANFP_28150	COG1472	Belongs to the glycosyl hydrolase 3 family
ANFP_28160	COG0531	amino acid
ANFP_28180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ANFP_28230	COG0363	glucosamine-6-phosphate deaminase activity
ANFP_28260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ANFP_28280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ANFP_28300	COG1449	Belongs to the glycosyl hydrolase 57 family
ANFP_28310	COG1940	carbohydrate kinase activity
ANFP_28320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ANFP_28330	COG2733	membrane
ANFP_28350	COG0629	single-stranded DNA binding
ANFP_28380	COG3118	belongs to the thioredoxin family
ANFP_28390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANFP_28420	COG0335	large ribosomal subunit rRNA binding
ANFP_28430	COG0336	Belongs to the RNA methyltransferase TrmD family
ANFP_28440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ANFP_28450	COG0228	four-way junction DNA binding
ANFP_28460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ANFP_28470	COG0431	NADPH-dependent FMN reductase
ANFP_28500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ANFP_28520	COG1131	(ABC) transporter
ANFP_28530	COG0842	Transport permease protein
ANFP_28540	COG0842	Transport permease protein
ANFP_28590	COG0509	glycine decarboxylation via glycine cleavage system
ANFP_28650	COG2210	Belongs to the sulfur carrier protein TusA family
ANFP_28670	COG0631	protein serine/threonine phosphatase activity
ANFP_28680	COG4245	von Willebrand factor, type A
ANFP_28710	COG1573	uracil-dna glycosylase
ANFP_28740	COG2336	PFAM SpoVT AbrB
ANFP_28770	COG2336	PFAM SpoVT AbrB
ANFP_28800	COG0488	(ABC) transporter
ANFP_28850	COG0142	geranyltranstransferase activity
ANFP_28880	COG3852	Histidine kinase
ANFP_28910	COG2308	Evidence 4 Homologs of previously reported genes of
ANFP_28940	COG2766	serine protein kinase
ANFP_28950	COG0004	ammonium transporteR
ANFP_28960	COG2718	Belongs to the UPF0229 family
ANFP_28970	COG2719	SpoVR family
ANFP_28990	COG0347	Belongs to the P(II) protein family
ANFP_29000	COG0004	ammonium transporteR
ANFP_29010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ANFP_29010	COG0519	Catalyzes the synthesis of GMP from XMP
ANFP_29040	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ANFP_29060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ANFP_29070	COG1686	Belongs to the peptidase S11 family
ANFP_29080	COG0166	Belongs to the GPI family
ANFP_29100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ANFP_29130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ANFP_29150	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ANFP_29160	COG1074	ATP-dependent DNA helicase activity
ANFP_29170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ANFP_29270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ANFP_29290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ANFP_29310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ANFP_29340	COG0424	maF-like protein
ANFP_29350	COG1530	ribonuclease E activity
ANFP_29360	COG2204	response regulator
ANFP_29380	COG2205	protein histidine kinase activity
ANFP_29400	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ANFP_29490	COG0438	transferase activity, transferring glycosyl groups
ANFP_29520	COG0175	sulfate reduction
ANFP_29530	COG2895	sulfate adenylyltransferase (ATP) activity
ANFP_29530	COG0529	Catalyzes the synthesis of activated sulfate
ANFP_29660	COG1132	(ABC) transporter
ANFP_29700	COG0444	Belongs to the ABC transporter superfamily
ANFP_29710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ANFP_29720	COG0601	transmembrane transport
ANFP_29770	COG2095	MarC family integral membrane protein
ANFP_29780	COG0039	L-malate dehydrogenase activity
ANFP_29800	COG0811	peptide transport
ANFP_29810	COG0848	biopolymer transport protein
ANFP_29840	COG0604	alcohol dehydrogenase
ANFP_29840	COG1028	Short-chain dehydrogenase reductase Sdr
ANFP_29840	COG3321	synthase
ANFP_29850	COG0156	8-amino-7-oxononanoate synthase activity
ANFP_29900	COG1194	a g-specific adenine glycosylase
ANFP_29920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ANFP_29930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ANFP_29950	COG1660	Displays ATPase and GTPase activities
ANFP_29960	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ANFP_29970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ANFP_29970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ANFP_29970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ANFP_30010	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ANFP_30030	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ANFP_30080	COG3178	'Phosphotransferase
ANFP_30090	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ANFP_30100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANFP_30110	COG0842	Transport permease protein
ANFP_30120	COG0271	Belongs to the BolA IbaG family
ANFP_30130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ANFP_30140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ANFP_30150	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ANFP_30170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ANFP_30180	COG0131	Imidazoleglycerol-phosphate dehydratase
ANFP_30190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ANFP_30200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ANFP_30210	COG0107	imidazoleglycerol-phosphate synthase activity
ANFP_30220	COG0140	phosphoribosyl-ATP diphosphatase activity
ANFP_30220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ANFP_30230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ANFP_30240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ANFP_30250	COG0805	protein transport
ANFP_30260	COG1850	ribulose-bisphosphate carboxylase activity
ANFP_30320	COG0540	Belongs to the ATCase OTCase family
ANFP_30330	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ANFP_30340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ANFP_30350	COG1678	Uncharacterized ACR, COG1678
ANFP_30360	COG0189	ligase activity
ANFP_30390	COG0316	Belongs to the HesB IscA family
ANFP_30400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANFP_30410	COG0022	dehydrogenase e1 component
ANFP_30410	COG0508	dehydrogenase complex catalyzes the overall conversion of
ANFP_30420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ANFP_30450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ANFP_30460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ANFP_30470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ANFP_30510	COG0778	Nitroreductase
ANFP_30530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ANFP_30540	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ANFP_30560	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ANFP_30570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ANFP_30580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANFP_30580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANFP_30590	COG1611	Belongs to the LOG family
ANFP_30610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ANFP_30640	COG1555	photosystem II stabilization
ANFP_30650	COG0210	DNA helicase
ANFP_30690	COG1796	DNA polymerase
ANFP_30690	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ANFP_30730	COG1028	Short-chain dehydrogenase reductase Sdr
ANFP_30750	COG1333	cytochrome c biogenesis protein
ANFP_30760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ANFP_30850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ANFP_30860	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ANFP_30870	COG0175	sulfate reduction
ANFP_30890	COG2895	sulfate adenylyltransferase (ATP) activity
ANFP_30930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ANFP_31000	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ANFP_31040	COG2814	Major facilitator Superfamily
ANFP_31050	COG0109	protoheme IX farnesyltransferase activity
ANFP_31070	COG4454	pyrroloquinoline quinone binding
ANFP_31110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ANFP_31120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ANFP_31200	COG0326	Molecular chaperone. Has ATPase activity
ANFP_31220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ANFP_31250	COG1131	(ABC) transporter
ANFP_31390	COG1484	DNA-dependent DNA replication
ANFP_31400	COG4584	PFAM Integrase catalytic
ANFP_31430	COG3039	Transposase
ANFP_31520	COG1715	Restriction endonuclease
ANFP_31600	COG1196	nuclear chromosome segregation
ANFP_31680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ANFP_31710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ANFP_31720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ANFP_31730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ANFP_31740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ANFP_31760	COG0356	it plays a direct role in the translocation of protons across the membrane
ANFP_31780	COG1475	DNA binding
ANFP_31800	COG0357	Ribosomal RNA small subunit methyltransferase G
ANFP_31810	COG0445	tRNA wobble uridine modification
ANFP_31840	COG0521	Mo-molybdopterin cofactor biosynthetic process
ANFP_31900	COG0655	NAD(P)H dehydrogenase (quinone) activity
ANFP_31980	COG1131	(ABC) transporter
ANFP_31990	COG2945	thiolester hydrolase activity
ANFP_32010	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ANFP_32020	COG1959	2 iron, 2 sulfur cluster binding
ANFP_32040	COG0134	indole-3-glycerol-phosphate synthase activity
ANFP_32050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ANFP_32080	COG0546	phosphoglycolate phosphatase activity
ANFP_32090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ANFP_32120	COG0126	phosphoglycerate kinase activity
ANFP_32130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ANFP_32140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ANFP_32150	COG1494	fructose-1,6-bisphosphatase
ANFP_32160	COG0483	inositol monophosphate 1-phosphatase activity
ANFP_32180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ANFP_32190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ANFP_32200	COG1322	Protein conserved in bacteria
ANFP_32210	COG1970	mechanosensitive ion channel activity
ANFP_32230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANFP_32240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANFP_32260	COG1671	Belongs to the UPF0178 family
ANFP_32370	COG0165	Argininosuccinate lyase
ANFP_32400	COG1881	PFAM PEBP family protein
ANFP_32450	COG2181	nitrate reductase activity
ANFP_32450	COG0247	lactate metabolic process
ANFP_32470	COG0375	protein maturation
ANFP_32500	COG0409	Hydrogenase expression formation protein
ANFP_32530	COG0662	Cupin 2, conserved barrel domain protein
ANFP_32530	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ANFP_32580	COG0113	porphobilinogen synthase activity
ANFP_32600	COG0181	hydroxymethylbilane synthase activity
ANFP_32620	COG0537	adenosine 5'-monophosphoramidase activity
ANFP_32630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ANFP_32640	COG0352	thiamine-phosphate diphosphorylase activity
ANFP_32650	COG0351	phosphomethylpyrimidine kinase
ANFP_32690	COG0509	glycine decarboxylation via glycine cleavage system
ANFP_32740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ANFP_32750	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ANFP_32780	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANFP_32810	COG1151	hydroxylamine reductase activity
ANFP_32820	COG0633	Ferredoxin
ANFP_32820	COG0543	2 iron, 2 sulfur cluster binding
ANFP_32870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ANFP_32930	COG2826	transposase and inactivated derivatives, IS30 family
ANFP_33100	COG2337	Toxic component of a toxin-antitoxin (TA) module
ANFP_33130	COG0583	DNA-binding transcription factor activity
ANFP_33140	COG2814	Major facilitator Superfamily
ANFP_33150	COG1538	Outer membrane efflux protein
ANFP_33160	COG1566	PFAM secretion protein HlyD family protein
ANFP_33170	COG1017	nitric oxide dioxygenase activity
ANFP_33170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANFP_t00030	COG0156	8-amino-7-oxononanoate synthase activity