locus-tag	class	description
FE661_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FE661_00010	COG0592	DNA-directed DNA polymerase activity
FE661_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FE661_00020	COG0187	DNA topoisomerase II activity
FE661_00025	COG0493	'glutamate synthase
FE661_00025	COG0543	2 iron, 2 sulfur cluster binding
FE661_00065	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FE661_00075	COG0850	regulation of cytokinetic process
FE661_00080	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FE661_00090	COG2922	Belongs to the Smg family
FE661_00095	COG0758	DNA mediated transformation
FE661_00105	COG0242	peptide deformylase activity
FE661_00110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FE661_00115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FE661_00125	COG5000	phosphorelay sensor kinase activity
FE661_00130	COG2204	response regulator
FE661_00140	COG3852	Histidine kinase
FE661_00145	COG2204	response regulator
FE661_00150	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FE661_00160	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FE661_00165	COG0706	membrane insertase activity
FE661_00170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FE661_00180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FE661_00185	COG0488	(ABC) transporter
FE661_00195	COG1566	PFAM secretion protein HlyD family protein
FE661_00275	COG2095	MarC family integral membrane protein
FE661_00285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FE661_00290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FE661_00300	COG0217	transcriptional regulatory protein
FE661_00305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FE661_00310	COG0632	four-way junction helicase activity
FE661_00315	COG2255	four-way junction helicase activity
FE661_00320	COG0824	Thioesterase
FE661_00340	COG0823	Involved in the tonB-independent uptake of proteins
FE661_00345	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FE661_00350	COG0602	queuosine metabolic process
FE661_00360	COG2885	chlorophyll binding
FE661_00395	COG2226	methyltransferase
FE661_00470	COG3177	Filamentation induced by cAMP protein fic
FE661_00500	COG1252	NADH dehydrogenase
FE661_00515	COG1136	(ABC) transporter
FE661_00530	COG1914	H( )-stimulated, divalent metal cation uptake system
FE661_00535	COG2205	protein histidine kinase activity
FE661_00540	COG0745	RESPONSE REGULATOR receiver
FE661_00550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE661_00555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FE661_00600	COG2833	Protein of unknown function (DUF455)
FE661_00605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FE661_00615	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FE661_00620	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FE661_00625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FE661_00630	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FE661_00660	COG1484	DNA-dependent DNA replication
FE661_00675	COG0629	single-stranded DNA binding
FE661_00750	COG3311	Transcriptional regulator
FE661_00810	COG4962	Type ii secretion system protein e
FE661_00825	COG3451	type IV secretory pathway VirB4
FE661_00855	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FE661_00860	COG3657	addiction module killer protein
FE661_00875	COG3701	Conjugal transfer protein
FE661_00940	COG1475	DNA binding
FE661_00945	COG1192	Involved in chromosome partitioning
FE661_00985	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FE661_01000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FE661_01045	COG0583	DNA-binding transcription factor activity
FE661_01065	COG0277	FAD linked oxidase domain protein
FE661_01070	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FE661_01075	COG0792	nuclease activity
FE661_01080	COG3107	peptidoglycan biosynthetic process
FE661_01105	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FE661_01115	COG2363	Small membrane protein
FE661_01125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FE661_01135	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FE661_01140	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FE661_01145	COG1127	ABC transporter
FE661_01150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FE661_01155	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FE661_01170	COG1131	(ABC) transporter
FE661_01175	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FE661_01180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FE661_01190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FE661_01205	COG0018	arginyl-trna synthetase
FE661_01215	COG0583	DNA-binding transcription factor activity
FE661_01225	COG0708	Exodeoxyribonuclease III
FE661_01235	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FE661_01240	COG0625	glutathione transferase activity
FE661_01245	COG0708	Exodeoxyribonuclease III
FE661_01250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FE661_01255	COG1047	Peptidyl-prolyl cis-trans
FE661_01260	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FE661_01265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FE661_01270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FE661_01285	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FE661_01290	COG0237	dephospho-CoA kinase activity
FE661_01295	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FE661_01300	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FE661_01315	COG0739	heme binding
FE661_01315	COG0741	lytic transglycosylase activity
FE661_01315	COG1196	nuclear chromosome segregation
FE661_01320	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FE661_01330	COG2264	protein methyltransferase activity
FE661_01335	COG0439	Biotin carboxylase
FE661_01345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FE661_01360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FE661_01370	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FE661_01375	COG1181	Belongs to the D-alanine--D-alanine ligase family
FE661_01380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FE661_01385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FE661_01390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FE661_01395	COG0772	Belongs to the SEDS family
FE661_01400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FE661_01405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FE661_01410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FE661_01415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FE661_01430	COG0275	rRNA processing
FE661_01435	COG2001	Belongs to the MraZ family
FE661_01450	COG0617	tRNA 3'-terminal CCA addition
FE661_01455	COG1022	Amp-dependent synthetase and ligase
FE661_01460	COG0625	glutathione transferase activity
FE661_01465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FE661_01475	COG0653	protein targeting
FE661_01480	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FE661_01485	COG0494	nUDIX hydrolase
FE661_01490	COG0463	Glycosyl transferase, family 2
FE661_01505	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FE661_01535	COG1519	Transferase
FE661_01540	COG1560	Kdo2-lipid A biosynthetic process
FE661_01545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FE661_01550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FE661_01555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FE661_01560	COG1040	competence protein
FE661_01565	COG0156	8-amino-7-oxononanoate synthase activity
FE661_01570	COG2267	carboxylic ester hydrolase activity
FE661_01575	COG2226	methyltransferase
FE661_01580	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FE661_01585	COG0501	Belongs to the peptidase M48B family
FE661_01590	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FE661_01595	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FE661_01600	COG0390	transport system, permease component
FE661_01610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FE661_01610	COG0543	2 iron, 2 sulfur cluster binding
FE661_01630	COG1309	transcriptional regulator
FE661_01635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FE661_01640	COG1566	PFAM secretion protein HlyD family protein
FE661_01650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FE661_01655	COG1872	DUF167
FE661_01705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FE661_01710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FE661_01715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FE661_01720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FE661_01740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FE661_01760	COG0735	belongs to the Fur family
FE661_01765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FE661_01770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FE661_01775	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FE661_01780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FE661_01785	COG0659	secondary active sulfate transmembrane transporter activity
FE661_01790	COG0288	reversible hydration of carbon dioxide
FE661_01795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FE661_01800	COG2226	methyltransferase
FE661_01810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FE661_01810	COG2813	Specifically methylates the guanine in position
FE661_01815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FE661_01825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FE661_01830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FE661_01835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FE661_01835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FE661_01850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FE661_01855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FE661_01875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FE661_01900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FE661_01920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FE661_01925	COG0081	regulation of translation
FE661_01930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FE661_01935	COG0222	ribosome binding
FE661_01940	COG0085	RNA polymerase activity
FE661_01945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FE661_01950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FE661_01955	COG0049	tRNA binding
FE661_01960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FE661_01965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FE661_01970	COG0051	transcription antitermination factor activity, RNA binding
FE661_01975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FE661_01980	COG0088	Forms part of the polypeptide exit tunnel
FE661_01985	COG0089	rRNA binding
FE661_01990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FE661_01995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FE661_02000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FE661_02010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FE661_02015	COG0255	Belongs to the universal ribosomal protein uL29 family
FE661_02020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FE661_02025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FE661_02030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FE661_02035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FE661_02040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FE661_02045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FE661_02050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FE661_02055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FE661_02060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FE661_02065	COG1841	ribosomal large subunit assembly
FE661_02070	COG0200	Binds to the 23S rRNA
FE661_02075	COG0201	protein transport
FE661_02080	COG0563	adenylate kinase activity
FE661_02085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FE661_02090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FE661_02095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FE661_02100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FE661_02105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FE661_02110	COG0202	RNA polymerase activity
FE661_02115	COG0203	ribosomal protein L17
FE661_02120	COG0756	dUTP diphosphatase activity
FE661_02125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FE661_02130	COG2003	Belongs to the UPF0758 family
FE661_02140	COG0671	phosphoesterase, PA-phosphatase related
FE661_02170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FE661_02175	COG0678	peroxiredoxin activity
FE661_02175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FE661_02180	COG0560	Phosphoserine phosphatase
FE661_02185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FE661_02190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FE661_02195	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FE661_02215	COG0492	ferredoxin-NADP+ reductase activity
FE661_02225	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FE661_02235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FE661_02240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FE661_02250	COG1376	ErfK ybiS ycfS ynhG family protein
FE661_02285	COG0779	Required for maturation of 30S ribosomal subunits
FE661_02290	COG0195	Participates in both transcription termination and antitermination
FE661_02295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FE661_02300	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FE661_02305	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FE661_02310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FE661_02315	COG1185	polyribonucleotide nucleotidyltransferase activity
FE661_02320	COG0612	Peptidase, M16
FE661_02325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FE661_02335	COG0328	RNA-DNA hybrid ribonuclease activity
FE661_02340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FE661_02350	COG0346	lactoylglutathione lyase activity
FE661_02360	COG0137	argininosuccinate synthase activity
FE661_02365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FE661_02370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FE661_02375	COG0527	aspartate kinase activity
FE661_02395	COG4115	mRNA cleavage
FE661_02425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FE661_02435	COG0741	lytic transglycosylase activity
FE661_02435	COG1388	LysM domain
FE661_02440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FE661_02450	COG0538	isocitrate dehydrogenase activity
FE661_02455	COG0045	succinate-CoA ligase (ADP-forming) activity
FE661_02465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FE661_02470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FE661_02470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FE661_02500	COG1850	ribulose-bisphosphate carboxylase activity
FE661_02505	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
FE661_02510	COG0235	Class ii aldolase
FE661_02520	COG0242	peptide deformylase activity
FE661_02525	COG0531	amino acid
FE661_02550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FE661_02560	COG2204	response regulator
FE661_02570	COG2205	protein histidine kinase activity
FE661_02575	COG0497	DNA recombination
FE661_02580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FE661_02585	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FE661_02590	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FE661_02590	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FE661_02595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FE661_02605	COG1466	dna polymerase III delta subunit
FE661_02615	COG0495	leucyl-tRNA aminoacylation
FE661_02620	COG0655	NAD(P)H dehydrogenase (quinone) activity
FE661_02625	COG2353	YceI-like domain
FE661_02630	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FE661_02635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FE661_02660	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FE661_02665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FE661_02680	COG0436	Aminotransferase
FE661_02690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FE661_02700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FE661_02705	COG4456	Virulence-associated protein
FE661_02710	COG1487	ribonuclease activity
FE661_02720	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FE661_02730	COG1136	(ABC) transporter
FE661_02740	COG2333	competence protein COMEC
FE661_02740	COG0658	competence protein
FE661_02745	COG0811	peptide transport
FE661_02750	COG0848	biopolymer transport protein
FE661_02765	COG1663	tetraacyldisaccharide 4'-kinase activity
FE661_02770	COG2835	tetraacyldisaccharide 4'-kinase activity
FE661_02775	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FE661_02800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FE661_02830	COG2329	Antibiotic biosynthesis monooxygenase
FE661_02850	COG3267	Type II secretory pathway component ExeA
FE661_02850	COG3409	Peptidoglycan-binding domain 1 protein
FE661_02880	COG1573	uracil-dna glycosylase
FE661_02885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FE661_02890	COG0542	response to heat
FE661_02895	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FE661_02900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FE661_02905	COG0693	protein deglycase activity
FE661_02910	COG0793	Belongs to the peptidase S41A family
FE661_02920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FE661_02925	COG0058	SHG alpha-glucan phosphorylase activity
FE661_02935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FE661_02940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FE661_02950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FE661_02955	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FE661_02980	COG2046	Belongs to the sulfate adenylyltransferase family
FE661_02980	COG0529	Catalyzes the synthesis of activated sulfate
FE661_02990	COG0459	protein refolding
FE661_02995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FE661_03020	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FE661_03030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FE661_03050	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FE661_03055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FE661_03060	COG0196	riboflavin kinase activity
FE661_03085	COG1561	YicC-like family, N-terminal region
FE661_03090	COG0194	GDP metabolic process
FE661_03095	COG1758	RNA polymerase activity
FE661_03100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FE661_03130	COG0628	permease
FE661_03135	COG1355	regulation of microtubule-based process
FE661_03140	COG2078	PFAM AMMECR1 domain protein
FE661_03150	COG1538	Outer membrane efflux protein
FE661_03185	COG0776	regulation of translation
FE661_03190	COG0393	Putative heavy-metal-binding
FE661_03200	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FE661_03210	COG0732	type I restriction modification DNA specificity domain
FE661_03220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FE661_03250	COG0776	regulation of translation
FE661_03395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FE661_03395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FE661_03425	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
FE661_03465	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FE661_03505	COG4962	Type ii secretion system protein e
FE661_03525	COG3451	type IV secretory pathway VirB4
FE661_03565	COG2948	multi-organism process
FE661_03615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FE661_03630	COG1192	Involved in chromosome partitioning
FE661_03635	COG1475	DNA binding
FE661_03735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FE661_03745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FE661_03765	COG0393	Putative heavy-metal-binding
FE661_03770	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
FE661_03820	COG0513	Belongs to the DEAD box helicase family
FE661_03825	COG1278	Cold shock
FE661_03830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FE661_03835	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FE661_03845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FE661_03855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FE661_03860	COG1702	phosphate starvation-inducible protein PhoH
FE661_03865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FE661_03875	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FE661_03880	COG0312	modulator of DNA gyrase
FE661_03890	COG1121	(ABC) transporter
FE661_03900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FE661_03945	COG0438	transferase activity, transferring glycosyl groups
FE661_03950	COG0438	transferase activity, transferring glycosyl groups
FE661_03955	COG1132	(ABC) transporter
FE661_03960	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FE661_03985	COG2226	methyltransferase
FE661_03990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FE661_03995	COG0066	3-isopropylmalate dehydratase activity
FE661_04005	COG0259	pyridoxamine-phosphate oxidase activity
FE661_04010	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FE661_04020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FE661_04025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FE661_04040	COG0109	protoheme IX farnesyltransferase activity
FE661_04045	COG2814	Major facilitator Superfamily
FE661_04050	COG1968	undecaprenyl-diphosphatase activity
FE661_04055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FE661_04065	COG0505	Belongs to the CarA family
FE661_04080	COG2022	thiamine diphosphate biosynthetic process
FE661_04090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FE661_04095	COG0163	prenyltransferase activity
FE661_04100	COG1127	ABC transporter
FE661_04105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FE661_04125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FE661_04140	COG1136	(ABC) transporter
FE661_04160	COG0254	rRNA binding
FE661_04165	COG0281	malic enzyme
FE661_04170	COG0628	permease
FE661_04175	COG0129	dihydroxy-acid dehydratase activity
FE661_04185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FE661_04185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FE661_04190	COG0271	Belongs to the BolA IbaG family
FE661_04195	COG2350	Protein conserved in bacteria
FE661_04200	COG2917	probably involved in intracellular septation
FE661_04215	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FE661_04225	COG1959	2 iron, 2 sulfur cluster binding
FE661_04230	COG1104	cysteine desulfurase activity
FE661_04235	COG0822	iron-sulfur transferase activity
FE661_04245	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FE661_04250	COG0443	Heat shock 70 kDa protein
FE661_04265	COG0482	sulfurtransferase activity
FE661_04270	COG1752	Esterase of the alpha-beta hydrolase superfamily
FE661_04295	COG0732	type I restriction modification DNA specificity domain
FE661_04320	COG4372	Transposase
FE661_04335	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FE661_04350	COG3284	Transcriptional regulator
FE661_04360	COG3791	Glutathione-dependent formaldehyde-activating
FE661_04365	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FE661_04370	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FE661_04375	COG0583	DNA-binding transcription factor activity
FE661_04380	COG2204	response regulator
FE661_04430	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FE661_04445	COG0298	carbon dioxide binding
FE661_04450	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FE661_04465	COG0375	protein maturation
FE661_04490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FE661_04520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FE661_04525	COG0493	'glutamate synthase
FE661_04530	COG0069	glutamate synthase activity
FE661_04530	COG0067	glutamate synthase
FE661_04530	COG0070	glutamate synthase
FE661_04535	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FE661_04540	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FE661_04545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FE661_04550	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FE661_04585	COG0432	Pfam Uncharacterised protein family UPF0047
FE661_04595	COG1193	negative regulation of DNA recombination
FE661_04600	COG0028	Belongs to the TPP enzyme family
FE661_04610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FE661_04615	COG0688	phosphatidylethanolamine metabolic process
FE661_04620	COG1183	phosphatidylcholine synthase activity
FE661_04630	COG0589	response to stress
FE661_04635	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FE661_04640	COG1196	nuclear chromosome segregation
FE661_04655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FE661_04685	COG0730	response to heat
FE661_04695	COG0811	peptide transport
FE661_04700	COG0848	biopolymer transport protein
FE661_04715	COG0402	S-adenosylhomocysteine deaminase activity
FE661_04720	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FE661_04755	COG3608	succinylglutamate desuccinylase aspartoacylase
FE661_04755	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FE661_04775	COG0746	molybdenum cofactor guanylyltransferase activity
FE661_04815	COG0475	glutathione-regulated potassium exporter activity
FE661_04820	COG1028	Short-chain dehydrogenase reductase Sdr
FE661_04890	COG2080	2 iron, 2 sulfur cluster binding
FE661_04890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FE661_04905	COG2814	Major facilitator Superfamily
FE661_04910	COG0038	chloride channel
FE661_04920	COG0583	DNA-binding transcription factor activity
FE661_04975	COG1196	nuclear chromosome segregation
FE661_04980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FE661_05020	COG3344	reverse transcriptase
FE661_05085	COG0419	ATPase involved in DNA repair
FE661_05160	COG2217	Heavy metal translocating P-type atpase
FE661_05165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FE661_05190	COG0789	Transcriptional regulator
FE661_05210	COG2608	mercury ion transmembrane transporter activity
FE661_05260	COG1595	DNA-templated transcription, initiation
FE661_05290	COG2995	paraquat-inducible protein a
FE661_05310	COG0531	amino acid
FE661_05315	COG0076	glutamate decarboxylase activity
FE661_05350	COG2814	Major facilitator Superfamily
FE661_05365	COG4584	PFAM Integrase catalytic
FE661_05380	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FE661_05435	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FE661_05480	COG1230	cation diffusion facilitator family transporter
FE661_05485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FE661_05485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FE661_05495	COG0477	Major facilitator Superfamily
FE661_05505	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FE661_05650	COG2378	regulation of single-species biofilm formation
FE661_05655	COG0640	Transcriptional regulator
FE661_05660	COG0697	spore germination
FE661_05735	COG1064	alcohol dehydrogenase
FE661_05740	COG0504	CTP synthase activity
FE661_05745	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FE661_05750	COG0148	phosphopyruvate hydratase activity
FE661_05755	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FE661_05760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FE661_05770	COG0322	excinuclease ABC activity
FE661_05795	COG3189	MarR family transcriptional regulator
FE661_05810	COG1017	nitric oxide dioxygenase activity
FE661_05810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FE661_05815	COG1566	PFAM secretion protein HlyD family protein
FE661_05820	COG1538	Outer membrane efflux protein
FE661_05825	COG2814	Major facilitator Superfamily
FE661_05830	COG0583	DNA-binding transcription factor activity
FE661_05855	COG2161	toxin-antitoxin pair type II binding
FE661_05870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FE661_05900	COG1247	-acetyltransferase
FE661_05950	COG0393	Putative heavy-metal-binding
FE661_05960	COG2026	Addiction module toxin, RelE StbE family
FE661_05970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FE661_05975	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FE661_05985	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FE661_05990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FE661_06000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FE661_06005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FE661_06010	COG0287	Prephenate dehydrogenase
FE661_06015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FE661_06020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FE661_06030	COG0776	regulation of translation
FE661_06035	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FE661_06040	COG0284	orotidine-5'-phosphate decarboxylase activity
FE661_06045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FE661_06050	COG0544	peptidyl-prolyl cis-trans isomerase activity
FE661_06060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FE661_06065	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FE661_06085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FE661_06090	COG0671	phosphoesterase, PA-phosphatase related
FE661_06115	COG2915	High frequency lysogenization protein hflD homolog
FE661_06120	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FE661_06125	COG0024	Methionine aminopeptidase
FE661_06130	COG1489	DNA binding
FE661_06135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FE661_06145	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FE661_06150	COG1546	Belongs to the CinA family
FE661_06150	COG1058	Belongs to the CinA family
FE661_06155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FE661_06160	COG2137	regulation of response to DNA damage stimulus
FE661_06200	COG0741	lytic transglycosylase activity
FE661_06200	COG1196	nuclear chromosome segregation
FE661_06200	COG0739	heme binding
FE661_06205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FE661_06220	COG0488	(ABC) transporter
FE661_06225	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FE661_06255	COG1294	oxidase, subunit
FE661_06280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FE661_06295	COG3416	Protein conserved in bacteria
FE661_06295	COG2943	transferase activity, transferring hexosyl groups
FE661_06305	COG2363	Small membrane protein
FE661_06360	COG0616	signal peptide processing
FE661_06365	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FE661_06370	COG0314	molybdopterin synthase activity
FE661_06375	COG1666	GTP binding
FE661_06385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FE661_06390	COG0509	glycine decarboxylation via glycine cleavage system
FE661_06395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FE661_06400	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FE661_06405	COG1132	(ABC) transporter
FE661_06410	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FE661_06415	COG0450	alkyl hydroperoxide reductase
FE661_06425	COG0613	PHP domain protein
FE661_06430	COG0628	permease
FE661_06450	COG0084	hydrolase, TatD family'
FE661_06455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FE661_06455	COG0321	lipoyl(octanoyl) transferase activity
FE661_06510	COG3846	protein secretion by the type IV secretion system
FE661_06545	COG0393	Putative heavy-metal-binding
FE661_06565	COG3451	type IV secretory pathway VirB4
FE661_06570	COG5268	conjugation
FE661_06585	COG4962	Type ii secretion system protein e
FE661_06690	COG0776	regulation of translation
FE661_06705	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FE661_06720	COG1215	transferase activity, transferring glycosyl groups
FE661_06830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FE661_06850	COG0210	DNA helicase
FE661_06865	COG1754	DNA topoisomerase type I activity
FE661_06865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FE661_06975	COG1285	pathogenesis
FE661_06980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FE661_07015	COG4680	protein conserved in bacteria
FE661_07040	COG4988	ABC transporter
FE661_07045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FE661_07055	COG0354	folic acid binding
FE661_07065	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FE661_07080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FE661_07085	COG0481	GTPase activity
FE661_07090	COG0681	Belongs to the peptidase S26 family
FE661_07100	COG0571	ribonuclease III activity
FE661_07105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FE661_07110	COG1381	Involved in DNA repair and RecF pathway recombination
FE661_07115	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FE661_07120	COG0736	holo-[acyl-carrier-protein] synthase activity
FE661_07130	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FE661_07130	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FE661_07135	COG0037	tRNA processing
FE661_07140	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FE661_07205	COG0438	transferase activity, transferring glycosyl groups
FE661_07220	COG1230	cation diffusion facilitator family transporter
FE661_07235	COG0513	Belongs to the DEAD box helicase family
FE661_07250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FE661_07255	COG0573	inorganic phosphate transmembrane transporter activity
FE661_07260	COG0581	inorganic phosphate transmembrane transporter activity
FE661_07265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FE661_07270	COG0704	Plays a role in the regulation of phosphate uptake
FE661_07285	COG0052	Belongs to the universal ribosomal protein uS2 family
FE661_07290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FE661_07295	COG0528	UMP kinase activity
FE661_07305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FE661_07310	COG0575	Belongs to the CDS family
FE661_07315	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FE661_07335	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FE661_07340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FE661_07345	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FE661_07350	COG0673	inositol 2-dehydrogenase activity
FE661_07360	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FE661_07365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FE661_07375	COG0825	malonyl-CoA metabolic process
FE661_07380	COG0037	tRNA processing
FE661_07390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FE661_07395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FE661_07405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FE661_07410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FE661_07415	COG1166	arginine decarboxylase activity
FE661_07460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FE661_07485	COG0811	peptide transport
FE661_07515	COG1120	ATPase activity
FE661_07525	COG0725	ABC transporter, periplasmic molybdate-binding protein
FE661_07535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FE661_07550	COG0725	ABC transporter, periplasmic molybdate-binding protein
FE661_07570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FE661_07625	COG5420	small protein containing a coiled-coil domain
FE661_07640	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
FE661_07645	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
FE661_07660	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
FE661_07670	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
FE661_07700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FE661_07735	COG1104	cysteine desulfurase activity
FE661_07740	COG5554	nitrogen fixation
FE661_07750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FE661_07755	COG0633	Ferredoxin
FE661_07780	COG1012	belongs to the aldehyde dehydrogenase family
FE661_07800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FE661_07805	COG0438	transferase activity, transferring glycosyl groups
FE661_07810	COG0438	transferase activity, transferring glycosyl groups
FE661_07815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FE661_07840	COG1666	GTP binding
FE661_07845	COG0438	transferase activity, transferring glycosyl groups
FE661_07850	COG0670	Belongs to the BI1 family
FE661_07875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FE661_07880	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FE661_07885	COG1428	Deoxynucleoside kinase
FE661_07895	COG3620	sequence-specific DNA binding
FE661_07895	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FE661_07895	COG0617	tRNA 3'-terminal CCA addition
FE661_07905	COG0463	Glycosyl transferase, family 2
FE661_07915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FE661_07915	COG0519	Catalyzes the synthesis of GMP from XMP
FE661_07925	COG4691	Plasmid stability protein
FE661_07930	COG1487	ribonuclease activity
FE661_07945	COG0531	amino acid
FE661_07950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FE661_07955	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FE661_07955	COG3264	Mechanosensitive ion channel
FE661_07970	COG0009	L-threonylcarbamoyladenylate synthase
FE661_07975	COG1994	Peptidase M50
FE661_07980	COG0180	Tryptophanyl-tRNA synthetase
FE661_07985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FE661_07990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FE661_07995	COG0446	pyridine nucleotide-disulphide oxidoreductase
FE661_08000	COG1187	pseudouridine synthase activity
FE661_08020	COG2814	Major facilitator Superfamily
FE661_08060	COG1105	Belongs to the carbohydrate kinase PfkB family
FE661_08065	COG0280	phosphate acetyltransferase
FE661_08070	COG0477	Major facilitator Superfamily
FE661_08075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FE661_08080	COG0508	dehydrogenase complex catalyzes the overall conversion of
FE661_08085	COG0022	dehydrogenase e1 component
FE661_08090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FE661_08100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FE661_08105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FE661_08105	COG0574	Belongs to the PEP-utilizing enzyme family
FE661_08120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FE661_08125	COG2171	N-acyltransferase activity
FE661_08145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FE661_08150	COG0402	S-adenosylhomocysteine deaminase activity
FE661_08160	COG0791	NLP P60 protein
FE661_08160	COG1388	LysM domain
FE661_08185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FE661_08230	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FE661_08245	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FE661_08255	COG1216	Glycosyl transferase, family 2
FE661_08280	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FE661_08285	COG1028	Short-chain dehydrogenase reductase Sdr
FE661_08300	COG2154	pterin-4-alpha-carbinolamine dehydratase
FE661_08330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FE661_08345	COG0587	DNA-directed DNA polymerase activity
FE661_08355	COG0308	aminopeptidase N
FE661_08375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FE661_08380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FE661_08400	COG0424	maF-like protein
FE661_08405	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FE661_08410	COG1923	regulation of RNA biosynthetic process
FE661_08415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FE661_08420	COG0330	HflC and HflK could
FE661_08425	COG0330	HflC and HflK could
FE661_08430	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FE661_08455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FE661_08475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FE661_08485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FE661_08490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FE661_08495	COG1295	ribonuclease BN
FE661_08505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FE661_08515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FE661_08540	COG1295	ribonuclease BN
FE661_08550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FE661_08555	COG0416	fatty acid biosynthetic process
FE661_08560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FE661_08565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FE661_08575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FE661_08580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FE661_08590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FE661_08595	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FE661_08625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FE661_08630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FE661_08635	COG0004	ammonium transporteR
FE661_08640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FE661_08640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FE661_08645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FE661_08655	COG0802	atpase or kinase
FE661_08660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FE661_08665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FE661_08670	COG0105	UTP biosynthetic process
FE661_08675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FE661_08690	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FE661_08695	COG0124	histidyl-tRNA synthetase
FE661_08710	COG1160	GTP binding
FE661_08745	COG0730	response to heat
FE661_08775	COG1881	PFAM PEBP family protein
FE661_08785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FE661_08810	COG0729	surface antigen
FE661_08830	COG4654	Cytochrome c, class I
FE661_08860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FE661_08870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FE661_08885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FE661_08890	COG1469	GTP cyclohydrolase I activity
FE661_08895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FE661_08900	COG0142	geranyltranstransferase activity
FE661_08910	COG2223	nitrite transmembrane transporter activity
FE661_08920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FE661_08925	COG1570	exodeoxyribonuclease VII activity
FE661_08930	COG2010	Cytochrome c
FE661_08930	COG4993	Dehydrogenase
FE661_08940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FE661_08945	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FE661_08955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FE661_08975	COG0583	DNA-binding transcription factor activity
FE661_08980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FE661_08990	COG2197	response regulator
FE661_09000	COG3916	Acyl-homoserine-lactone synthase
FE661_09065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FE661_09070	COG0456	acetyltransferase
FE661_09100	COG2217	Heavy metal translocating P-type atpase
FE661_09105	COG0436	Aminotransferase
FE661_09115	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FE661_09120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FE661_09125	COG0640	Transcriptional regulator
FE661_09130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FE661_09140	COG0187	DNA topoisomerase II activity
FE661_09145	COG0642	Histidine kinase
FE661_09150	COG0745	RESPONSE REGULATOR receiver
FE661_09230	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FE661_09245	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FE661_09250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FE661_09255	COG1862	Preprotein translocase
FE661_09260	COG0343	queuine tRNA-ribosyltransferase activity
FE661_09265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FE661_09270	COG1253	flavin adenine dinucleotide binding
FE661_09285	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FE661_09295	COG0285	dihydrofolate synthase activity
FE661_09300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FE661_09305	COG0159	tryptophan synthase activity
FE661_09310	COG0133	tryptophan synthase activity
FE661_09315	COG0135	phosphoribosylanthranilate isomerase activity
FE661_09320	COG0101	tRNA pseudouridine synthase activity
FE661_09330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FE661_09340	COG0746	molybdenum cofactor guanylyltransferase activity
FE661_09345	COG1763	Mo-molybdopterin cofactor biosynthetic process
FE661_09350	COG0303	'Molybdopterin
FE661_09355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FE661_09360	COG0616	signal peptide processing
FE661_09375	COG0438	transferase activity, transferring glycosyl groups
FE661_09405	COG0501	Belongs to the peptidase M48B family
FE661_09410	COG0477	Major facilitator Superfamily
FE661_09485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE661_09490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FE661_09515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FE661_09520	COG0154	amidase activity
FE661_09525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FE661_09560	COG3394	polysaccharide catabolic process
FE661_09575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FE661_09580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FE661_09585	COG1657	PFAM Prenyltransferase squalene oxidase
FE661_09590	COG1562	ergosterol biosynthetic process
FE661_09595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FE661_09600	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FE661_09620	COG1012	belongs to the aldehyde dehydrogenase family
FE661_09625	COG0442	prolyl-tRNA aminoacylation
FE661_09645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FE661_09660	COG1692	metallophosphoesterase
FE661_09665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FE661_09685	COG0768	penicillin binding
FE661_09690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FE661_09695	COG0193	aminoacyl-tRNA hydrolase activity
FE661_09700	COG0012	GTP binding
FE661_09705	COG1396	sequence-specific DNA binding
FE661_09710	COG0651	ATP synthesis coupled electron transport
FE661_09715	COG0650	Formate hydrogenlyase subunit 4
FE661_09725	COG0651	ATP synthesis coupled electron transport
FE661_09730	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
FE661_09730	COG3261	NADH dehydrogenase
FE661_09735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE661_09740	COG1850	ribulose-bisphosphate carboxylase activity
FE661_09760	COG2824	Alkylphosphonate utilization operon protein PhnA
FE661_09765	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FE661_09800	COG1649	PFAM Uncharacterised BCR, COG1649
FE661_09800	COG0726	polysaccharide deacetylase
FE661_09810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FE661_09815	COG0494	nUDIX hydrolase
FE661_09825	COG1187	pseudouridine synthase activity
FE661_09830	COG2957	Belongs to the agmatine deiminase family
FE661_09835	COG0243	molybdopterin cofactor binding
FE661_09865	COG0589	response to stress
FE661_09870	COG2814	Major facilitator Superfamily
FE661_09885	COG0210	DNA helicase
FE661_09890	COG0268	Binds directly to 16S ribosomal RNA
FE661_09895	COG3842	ATPase activity
FE661_09910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FE661_09915	COG0514	ATP-dependent DNA helicase (RecQ)
FE661_09920	COG1965	Belongs to the frataxin family
FE661_09940	COG0795	lipopolysaccharide-transporting ATPase activity
FE661_09945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FE661_09960	COG0525	valine-tRNA ligase activity
FE661_09965	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FE661_09990	COG0412	Dienelactone hydrolase
FE661_09995	COG1902	pentaerythritol trinitrate reductase activity
FE661_10010	COG3152	Membrane
FE661_10040	COG1530	ribonuclease E activity
FE661_10045	COG0215	cysteine-tRNA ligase activity
FE661_10050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FE661_10065	COG1028	Short-chain dehydrogenase reductase Sdr
FE661_10085	COG0745	RESPONSE REGULATOR receiver
FE661_10090	COG2205	protein histidine kinase activity
FE661_10100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FE661_10105	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FE661_10110	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FE661_10120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FE661_10180	COG4953	penicillin-binding protein 1C
FE661_10210	COG0138	bifunctional purine biosynthesis protein purh
FE661_10215	COG0151	Belongs to the GarS family
FE661_10220	COG0009	L-threonylcarbamoyladenylate synthase
FE661_10225	COG0408	coproporphyrinogen oxidase activity
FE661_10230	COG0167	dihydroorotate dehydrogenase activity
FE661_10255	COG0811	peptide transport
FE661_10270	COG0811	peptide transport
FE661_10290	COG0477	Major facilitator Superfamily
FE661_10295	COG3624	Phosphonate C-P lyase system protein PhnG
FE661_10300	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
FE661_10305	COG3626	phosphonate metabolism
FE661_10310	COG3627	carbon phosphorus lyase activity
FE661_10315	COG4107	phosphonate C-P lyase system protein PhnK
FE661_10320	COG4778	phosphonate C-P lyase system protein PhnL
FE661_10325	COG3454	Phosphonate metabolism
FE661_10335	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FE661_10340	COG2188	Transcriptional regulator
FE661_10370	COG1131	(ABC) transporter
FE661_10385	COG3511	phospholipase C
FE661_10395	COG0811	peptide transport
FE661_10410	COG4774	siderophore transport
FE661_10450	COG2814	Major facilitator Superfamily
FE661_10460	COG2062	phosphohistidine phosphatase, SixA
FE661_10475	COG2205	protein histidine kinase activity
FE661_10480	COG0745	RESPONSE REGULATOR receiver
FE661_10485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FE661_10490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FE661_10505	COG0033	Phosphoglucomutase
FE661_10525	COG3038	cytochrome b561
FE661_10535	COG2814	Major facilitator Superfamily
FE661_10540	COG0583	DNA-binding transcription factor activity
FE661_10560	COG1193	negative regulation of DNA recombination
FE661_10570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FE661_10580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FE661_10585	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FE661_10600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FE661_10620	COG1686	Belongs to the peptidase S11 family
FE661_10720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FE661_10725	COG0393	Putative heavy-metal-binding
FE661_10750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FE661_10760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FE661_10875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FE661_10930	COG2259	Doxx family
FE661_10940	COG0655	NAD(P)H dehydrogenase (quinone) activity
FE661_10945	COG1733	regulation of RNA biosynthetic process
FE661_10975	COG1846	Transcriptional regulator
FE661_10985	COG2353	YceI-like domain
FE661_11010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FE661_11035	COG0625	glutathione transferase activity
FE661_11050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FE661_11055	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FE661_11105	COG0667	Aldo Keto reductase
FE661_11120	COG1192	Involved in chromosome partitioning
FE661_11125	COG1475	DNA binding
FE661_11165	COG5001	Diguanylate cyclase
FE661_11165	COG3300	MHYT domain
FE661_11225	COG3701	Conjugal transfer protein
FE661_11240	COG1850	ribulose-bisphosphate carboxylase activity
FE661_11295	COG1192	Involved in chromosome partitioning
FE661_11320	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FE661_11325	COG0009	L-threonylcarbamoyladenylate synthase
FE661_11330	COG0129	dihydroxy-acid dehydratase activity
FE661_11335	COG0418	dihydroorotase activity
FE661_11370	COG0277	FAD linked oxidase domain protein
FE661_11375	COG0277	FAD linked oxidase domain protein
FE661_11380	COG0247	lactate metabolic process
FE661_11385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FE661_11390	COG3002	Belongs to the UPF0753 family
FE661_11420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FE661_11430	COG0243	molybdopterin cofactor binding
FE661_11435	COG2084	Dehydrogenase
FE661_11450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FE661_11490	COG3451	type IV secretory pathway VirB4
FE661_11510	COG4962	Type ii secretion system protein e
FE661_11525	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FE661_11545	COG4372	Transposase
FE661_11670	COG3077	Addiction module antitoxin, RelB DinJ family
FE661_11695	COG0776	regulation of translation
FE661_11700	COG0776	regulation of translation
FE661_11725	COG1002	Type II restriction enzyme, methylase subunits
FE661_11735	COG1061	Type III restriction enzyme res subunit
FE661_11740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FE661_11745	COG0028	Belongs to the TPP enzyme family
FE661_11760	COG0328	RNA-DNA hybrid ribonuclease activity
FE661_11805	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FE661_11845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FE661_11850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FE661_11860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FE661_11870	COG1272	protein, Hemolysin III
FE661_11875	COG0860	N-Acetylmuramoyl-L-alanine amidase
FE661_11885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FE661_11890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FE661_11900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FE661_11905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE661_11915	COG0640	Transcriptional regulator
FE661_11975	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FE661_11980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FE661_11995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FE661_12005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FE661_12010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FE661_12055	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FE661_12060	COG4974	Belongs to the 'phage' integrase family
FE661_12115	COG0454	-acetyltransferase
FE661_12120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE661_12195	COG4372	Transposase
FE661_12210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FE661_12225	COG5001	Diguanylate cyclase
FE661_12260	COG1846	Transcriptional regulator
FE661_12270	COG2353	YceI-like domain
FE661_12300	COG0776	regulation of translation
FE661_12305	COG0776	regulation of translation
FE661_12320	COG0393	Putative heavy-metal-binding
FE661_12325	COG0477	Major facilitator Superfamily
FE661_12340	COG0811	peptide transport
FE661_12385	COG4372	Transposase
FE661_12405	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FE661_12410	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FE661_12415	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FE661_12425	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FE661_12455	COG0789	Transcriptional regulator
FE661_12525	COG4584	PFAM Integrase catalytic
FE661_12600	COG0789	Transcriptional regulator
FE661_12630	COG1199	ATP-dependent helicase activity
FE661_12640	COG0791	NLP P60 protein
FE661_12655	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FE661_12670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FE661_12675	COG0586	Pfam SNARE associated Golgi protein
FE661_12690	COG0583	DNA-binding transcription factor activity
FE661_12705	COG0123	including yeast histone deacetylase and acetoin utilization protein
FE661_12755	COG0644	oxidoreductase
FE661_12760	COG0095	Lipoate-protein ligase
FE661_12770	COG0509	glycine decarboxylation via glycine cleavage system
FE661_12780	COG0509	glycine decarboxylation via glycine cleavage system
FE661_12785	COG2048	Heterodisulfide reductase, subunit B
FE661_12815	COG2210	Belongs to the sulfur carrier protein TusA family
FE661_12820	COG0425	Belongs to the sulfur carrier protein TusA family
FE661_12825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FE661_12830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FE661_12840	COG0315	cyclic pyranopterin monophosphate synthase activity
FE661_12845	COG1077	Cell shape determining protein MreB Mrl
FE661_12850	COG1792	Involved in formation and maintenance of cell shape
FE661_12860	COG0768	penicillin binding
FE661_12865	COG0772	Belongs to the SEDS family
FE661_12870	COG1686	Belongs to the peptidase S11 family
FE661_12880	COG0321	lipoyl(octanoyl) transferase activity
FE661_12885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FE661_12935	COG0751	glycine-tRNA ligase activity
FE661_12940	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FE661_12950	COG0189	ligase activity
FE661_12970	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FE661_13000	COG0625	glutathione transferase activity
FE661_13005	COG1733	regulation of RNA biosynthetic process
FE661_13010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FE661_13045	COG1131	(ABC) transporter
FE661_13065	COG0776	regulation of translation
FE661_13070	COG0072	phenylalanine-tRNA ligase activity
FE661_13070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FE661_13075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FE661_13080	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FE661_13085	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FE661_13090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FE661_13095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FE661_13105	COG1007	ATP synthesis coupled electron transport
FE661_13120	COG0713	ATP synthesis coupled electron transport
FE661_13130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE661_13135	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FE661_13140	COG1034	ATP synthesis coupled electron transport
FE661_13150	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FE661_13155	COG0649	NAD binding
FE661_13160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE661_13165	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE661_13170	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE661_13180	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FE661_13185	COG0149	triose-phosphate isomerase activity
FE661_13190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FE661_13195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FE661_13200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FE661_13205	COG0312	modulator of DNA gyrase
FE661_13210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FE661_13210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FE661_13215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FE661_13235	COG0477	Major facilitator Superfamily
FE661_13270	COG2372	response to copper ion
FE661_13270	COG1276	copper resistance
FE661_13280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FE661_13315	COG0717	Belongs to the dCTP deaminase family
FE661_13320	COG0489	protein tyrosine kinase activity
FE661_13330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FE661_13335	COG0484	heat shock protein binding
FE661_13340	COG0443	Heat shock 70 kDa protein
FE661_13345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FE661_13350	COG1420	regulation of RNA biosynthetic process
FE661_13355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FE661_13360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FE661_13365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FE661_13365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FE661_13370	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FE661_13375	COG0114	fumarate hydratase activity
FE661_13400	COG0297	glycogen (starch) synthase activity
FE661_13405	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FE661_13415	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FE661_13465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE661_13480	COG2204	response regulator
FE661_13520	COG4964	Belongs to the GSP D family
FE661_13570	COG0457	Tetratricopeptide repeat
FE661_13600	COG0826	peptidase U32
FE661_13605	COG0826	peptidase U32
FE661_13610	COG3154	lipid carrier protein
FE661_13630	COG1028	Short-chain dehydrogenase reductase Sdr
FE661_13635	COG0723	plastoquinol--plastocyanin reductase activity
FE661_13640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FE661_13645	COG2857	Cytochrome c1
FE661_13670	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FE661_13675	COG1534	Rna-binding protein
FE661_13680	COG2967	ApaG domain
FE661_13685	COG2226	methyltransferase
FE661_13705	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FE661_13715	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FE661_13725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FE661_13740	COG2177	Part of the ABC transporter FtsEX involved in
FE661_13745	COG2884	Cell division ATP-binding protein ftsE
FE661_13750	COG0552	protein localization to endoplasmic reticulum
FE661_13755	COG0742	ribosomal rna small subunit methyltransferase
FE661_13760	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FE661_13765	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FE661_13770	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FE661_13775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FE661_13780	COG2890	protein-(glutamine-N5) methyltransferase activity
FE661_13785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FE661_13790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FE661_13800	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FE661_13805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FE661_13815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FE661_13850	COG0625	glutathione transferase activity
FE661_13870	COG1484	DNA-dependent DNA replication
FE661_13875	COG4584	PFAM Integrase catalytic
FE661_13930	COG0393	Putative heavy-metal-binding
FE661_13940	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FE661_13950	COG0732	type I restriction modification DNA specificity domain
FE661_13965	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FE661_13995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FE661_14060	COG0006	proline dipeptidase activity
FE661_14075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FE661_14080	COG0305	Participates in initiation and elongation during chromosome replication
FE661_14085	COG0359	binds to the 23S rRNA
FE661_14100	COG0360	Binds together with S18 to 16S ribosomal RNA
FE661_14105	COG1472	Belongs to the glycosyl hydrolase 3 family
FE661_14110	COG0531	amino acid
FE661_14120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FE661_14145	COG0363	glucosamine-6-phosphate deaminase activity
FE661_14160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FE661_14165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FE661_14175	COG1449	Belongs to the glycosyl hydrolase 57 family
FE661_14180	COG1940	carbohydrate kinase activity
FE661_14185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FE661_14190	COG2733	membrane
FE661_14200	COG0629	single-stranded DNA binding
FE661_14215	COG3118	belongs to the thioredoxin family
FE661_14220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FE661_14235	COG0335	large ribosomal subunit rRNA binding
FE661_14240	COG0336	Belongs to the RNA methyltransferase TrmD family
FE661_14245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FE661_14250	COG0228	four-way junction DNA binding
FE661_14255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FE661_14260	COG0431	NADPH-dependent FMN reductase
FE661_14275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FE661_14285	COG1131	(ABC) transporter
FE661_14290	COG0842	Transport permease protein
FE661_14295	COG0842	Transport permease protein
FE661_14320	COG0509	glycine decarboxylation via glycine cleavage system
FE661_14350	COG0583	DNA-binding transcription factor activity
FE661_14355	COG2210	Belongs to the sulfur carrier protein TusA family
FE661_14370	COG0631	protein serine/threonine phosphatase activity
FE661_14375	COG4245	von Willebrand factor, type A
FE661_14390	COG1573	uracil-dna glycosylase
FE661_14405	COG2336	PFAM SpoVT AbrB
FE661_14420	COG2336	PFAM SpoVT AbrB
FE661_14465	COG0142	geranyltranstransferase activity
FE661_14480	COG3852	Histidine kinase
FE661_14490	COG2308	Evidence 4 Homologs of previously reported genes of
FE661_14505	COG2766	serine protein kinase
FE661_14510	COG0004	ammonium transporteR
FE661_14515	COG2718	Belongs to the UPF0229 family
FE661_14520	COG2719	SpoVR family
FE661_14530	COG0347	Belongs to the P(II) protein family
FE661_14535	COG0004	ammonium transporteR
FE661_14540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FE661_14540	COG0519	Catalyzes the synthesis of GMP from XMP
FE661_14555	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FE661_14565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FE661_14570	COG1686	Belongs to the peptidase S11 family
FE661_14575	COG0166	Belongs to the GPI family
FE661_14585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FE661_14600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FE661_14610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FE661_14615	COG1074	ATP-dependent DNA helicase activity
FE661_14620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FE661_14665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FE661_14675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FE661_14685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FE661_14700	COG0424	maF-like protein
FE661_14705	COG1530	ribonuclease E activity
FE661_14710	COG2204	response regulator
FE661_14720	COG2205	protein histidine kinase activity
FE661_14730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FE661_14775	COG0438	transferase activity, transferring glycosyl groups
FE661_14815	COG2895	sulfate adenylyltransferase (ATP) activity
FE661_14815	COG0529	Catalyzes the synthesis of activated sulfate
FE661_14880	COG1132	(ABC) transporter
FE661_14900	COG0444	Belongs to the ABC transporter superfamily
FE661_14905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FE661_14910	COG0601	transmembrane transport
FE661_14945	COG2095	MarC family integral membrane protein
FE661_14950	COG0039	L-malate dehydrogenase activity
FE661_14965	COG0811	peptide transport
FE661_14970	COG0848	biopolymer transport protein
FE661_14990	COG0604	alcohol dehydrogenase
FE661_14990	COG1028	Short-chain dehydrogenase reductase Sdr
FE661_14990	COG3321	synthase
FE661_14995	COG0156	8-amino-7-oxononanoate synthase activity
FE661_15020	COG1194	a g-specific adenine glycosylase
FE661_15030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FE661_15035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FE661_15045	COG1660	Displays ATPase and GTPase activities
FE661_15050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FE661_15055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FE661_15055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FE661_15055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FE661_15075	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FE661_15085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FE661_15110	COG3178	'Phosphotransferase
FE661_15115	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FE661_15120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FE661_15125	COG0842	Transport permease protein
FE661_15130	COG0271	Belongs to the BolA IbaG family
FE661_15135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FE661_15140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FE661_15145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FE661_15155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FE661_15160	COG0131	Imidazoleglycerol-phosphate dehydratase
FE661_15165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FE661_15170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FE661_15175	COG0107	imidazoleglycerol-phosphate synthase activity
FE661_15180	COG0140	phosphoribosyl-ATP diphosphatase activity
FE661_15180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FE661_15185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FE661_15190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FE661_15195	COG0805	protein transport
FE661_15200	COG1850	ribulose-bisphosphate carboxylase activity
FE661_15235	COG0540	Belongs to the ATCase OTCase family
FE661_15240	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FE661_15245	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FE661_15250	COG1678	Uncharacterized ACR, COG1678
FE661_15255	COG0189	ligase activity
FE661_15270	COG0316	Belongs to the HesB IscA family
FE661_15275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FE661_15280	COG0022	dehydrogenase e1 component
FE661_15280	COG0508	dehydrogenase complex catalyzes the overall conversion of
FE661_15285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FE661_15300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FE661_15305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FE661_15310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FE661_15330	COG0778	Nitroreductase
FE661_15365	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FE661_15370	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FE661_15380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FE661_15385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FE661_15390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FE661_15390	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FE661_15395	COG1611	Belongs to the LOG family
FE661_15405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FE661_15420	COG1555	photosystem II stabilization
FE661_15425	COG0210	DNA helicase
FE661_15445	COG1796	DNA polymerase
FE661_15445	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FE661_15460	COG1028	Short-chain dehydrogenase reductase Sdr
FE661_15465	COG0723	plastoquinol--plastocyanin reductase activity
FE661_15470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FE661_15480	COG1333	cytochrome c biogenesis protein
FE661_15485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FE661_15530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FE661_15535	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FE661_15540	COG0175	sulfate reduction
FE661_15550	COG2895	sulfate adenylyltransferase (ATP) activity
FE661_15575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FE661_15600	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FE661_15620	COG2814	Major facilitator Superfamily
FE661_15635	COG4454	pyrroloquinoline quinone binding
FE661_15650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FE661_15655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FE661_15695	COG0326	Molecular chaperone. Has ATPase activity
FE661_15705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FE661_15720	COG1131	(ABC) transporter
FE661_15840	COG1715	Restriction endonuclease
FE661_15890	COG1196	nuclear chromosome segregation
FE661_15930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FE661_15945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FE661_15950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FE661_15955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FE661_15960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FE661_15970	COG0356	it plays a direct role in the translocation of protons across the membrane
FE661_15980	COG1475	DNA binding
FE661_15990	COG0357	Ribosomal RNA small subunit methyltransferase G
FE661_15995	COG0445	tRNA wobble uridine modification
FE661_16010	COG0521	Mo-molybdopterin cofactor biosynthetic process
FE661_16040	COG0655	NAD(P)H dehydrogenase (quinone) activity
FE661_16090	COG1131	(ABC) transporter
FE661_16095	COG2945	thiolester hydrolase activity
FE661_16105	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FE661_16110	COG1959	2 iron, 2 sulfur cluster binding
FE661_16120	COG0134	indole-3-glycerol-phosphate synthase activity
FE661_16125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FE661_16140	COG0546	phosphoglycolate phosphatase activity
FE661_16145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FE661_16160	COG0126	phosphoglycerate kinase activity
FE661_16165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FE661_16170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FE661_16175	COG1494	fructose-1,6-bisphosphatase
FE661_16180	COG0483	inositol monophosphate 1-phosphatase activity
FE661_16190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FE661_16195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FE661_16200	COG1322	Protein conserved in bacteria
FE661_16205	COG1970	mechanosensitive ion channel activity
FE661_16215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FE661_16220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE661_16230	COG1671	Belongs to the UPF0178 family
FE661_16270	COG0745	RESPONSE REGULATOR receiver
FE661_16275	COG2205	protein histidine kinase activity
FE661_16285	COG0165	Argininosuccinate lyase
FE661_16325	COG0247	lactate metabolic process
FE661_16325	COG2181	nitrate reductase activity
FE661_16335	COG0375	protein maturation
FE661_16350	COG0409	Hydrogenase expression formation protein
FE661_16365	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FE661_16365	COG0662	Cupin 2, conserved barrel domain protein
FE661_16390	COG0113	porphobilinogen synthase activity
FE661_16400	COG0181	hydroxymethylbilane synthase activity
FE661_16410	COG0537	adenosine 5'-monophosphoramidase activity
FE661_16415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FE661_16420	COG0352	thiamine-phosphate diphosphorylase activity
FE661_16425	COG0351	phosphomethylpyrimidine kinase
FE661_16445	COG2337	Toxic component of a toxin-antitoxin (TA) module
FE661_16465	COG2814	Major facilitator Superfamily
FE661_16470	COG1538	Outer membrane efflux protein
FE661_16475	COG1566	PFAM secretion protein HlyD family protein
FE661_16480	COG1017	nitric oxide dioxygenase activity
FE661_16480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FE661_16500	COG0509	glycine decarboxylation via glycine cleavage system
FE661_16530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FE661_16535	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FE661_16550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FE661_16570	COG1151	hydroxylamine reductase activity
FE661_16575	COG0633	Ferredoxin
FE661_16575	COG0543	2 iron, 2 sulfur cluster binding
FE661_16600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FE661_16605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FE661_16625	COG2826	transposase and inactivated derivatives, IS30 family