locus-tag	class	description
F6A13_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F6A13_00010	COG0592	DNA-directed DNA polymerase activity
F6A13_00020	COG0187	DNA topoisomerase II activity
F6A13_00025	COG0493	'glutamate synthase
F6A13_00025	COG0543	2 iron, 2 sulfur cluster binding
F6A13_00050	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F6A13_00055	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F6A13_00060	COG2894	cell division
F6A13_00065	COG0850	regulation of cytokinetic process
F6A13_00070	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F6A13_00080	COG2922	Belongs to the Smg family
F6A13_00085	COG0758	DNA mediated transformation
F6A13_00095	COG0242	peptide deformylase activity
F6A13_00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F6A13_00105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F6A13_00115	COG5000	phosphorelay sensor kinase activity
F6A13_00120	COG2204	response regulator
F6A13_00145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F6A13_00150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F6A13_00165	COG4454	pyrroloquinoline quinone binding
F6A13_00175	COG0109	protoheme IX farnesyltransferase activity
F6A13_00180	COG2814	Major facilitator Superfamily
F6A13_00200	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
F6A13_00235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F6A13_00260	COG2895	sulfate adenylyltransferase (ATP) activity
F6A13_00270	COG0175	sulfate reduction
F6A13_00275	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F6A13_00280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F6A13_00325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F6A13_00330	COG1333	cytochrome c biogenesis protein
F6A13_00340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F6A13_00345	COG0723	plastoquinol--plastocyanin reductase activity
F6A13_00350	COG1028	Short-chain dehydrogenase reductase Sdr
F6A13_00365	COG2204	response regulator
F6A13_00370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F6A13_00380	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F6A13_00385	COG0706	membrane insertase activity
F6A13_00390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F6A13_00395	COG0594	ribonuclease P activity
F6A13_00400	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F6A13_00405	COG0488	(ABC) transporter
F6A13_00415	COG1566	PFAM secretion protein HlyD family protein
F6A13_00495	COG2095	MarC family integral membrane protein
F6A13_00505	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F6A13_00510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F6A13_00520	COG0217	transcriptional regulatory protein
F6A13_00525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F6A13_00530	COG0632	four-way junction helicase activity
F6A13_00535	COG2255	four-way junction helicase activity
F6A13_00540	COG0824	Thioesterase
F6A13_00560	COG0823	Involved in the tonB-independent uptake of proteins
F6A13_00565	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F6A13_00570	COG0602	queuosine metabolic process
F6A13_00580	COG2885	chlorophyll binding
F6A13_00590	COG4691	Plasmid stability protein
F6A13_00610	COG2161	toxin-antitoxin pair type II binding
F6A13_00615	COG4115	mRNA cleavage
F6A13_00710	COG0789	Transcriptional regulator
F6A13_00775	COG1252	NADH dehydrogenase
F6A13_00790	COG1136	(ABC) transporter
F6A13_00805	COG2205	protein histidine kinase activity
F6A13_00810	COG0745	RESPONSE REGULATOR receiver
F6A13_00820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6A13_00855	COG2833	Protein of unknown function (DUF455)
F6A13_00860	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F6A13_00870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F6A13_00875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F6A13_00880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F6A13_00910	COG0583	DNA-binding transcription factor activity
F6A13_00930	COG0277	FAD linked oxidase domain protein
F6A13_00935	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F6A13_00940	COG0792	nuclease activity
F6A13_00945	COG3107	peptidoglycan biosynthetic process
F6A13_00960	COG0582	viral genome integration into host DNA
F6A13_00975	COG0535	radical SAM domain protein
F6A13_01015	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F6A13_01035	COG3077	Addiction module antitoxin, RelB DinJ family
F6A13_01040	COG1902	pentaerythritol trinitrate reductase activity
F6A13_01065	COG2363	Small membrane protein
F6A13_01075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F6A13_01085	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F6A13_01090	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
F6A13_01095	COG1127	ABC transporter
F6A13_01100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F6A13_01105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F6A13_01120	COG1131	(ABC) transporter
F6A13_01125	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F6A13_01130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F6A13_01140	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F6A13_01155	COG0018	arginyl-trna synthetase
F6A13_01165	COG0583	DNA-binding transcription factor activity
F6A13_01175	COG0708	Exodeoxyribonuclease III
F6A13_01185	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F6A13_01190	COG0625	glutathione transferase activity
F6A13_01195	COG0708	Exodeoxyribonuclease III
F6A13_01200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F6A13_01205	COG1047	Peptidyl-prolyl cis-trans
F6A13_01210	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F6A13_01215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F6A13_01220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F6A13_01240	COG0237	dephospho-CoA kinase activity
F6A13_01245	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
F6A13_01250	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F6A13_01260	COG0741	lytic transglycosylase activity
F6A13_01260	COG0739	heme binding
F6A13_01260	COG1196	nuclear chromosome segregation
F6A13_01265	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
F6A13_01275	COG2264	protein methyltransferase activity
F6A13_01280	COG0439	Biotin carboxylase
F6A13_01285	COG0511	ligase activity, forming carbon-carbon bonds
F6A13_01290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F6A13_01305	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F6A13_01315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F6A13_01320	COG1181	Belongs to the D-alanine--D-alanine ligase family
F6A13_01325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F6A13_01330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F6A13_01335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F6A13_01340	COG0772	Belongs to the SEDS family
F6A13_01345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F6A13_01350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F6A13_01355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F6A13_01360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F6A13_01375	COG0275	rRNA processing
F6A13_01380	COG2001	Belongs to the MraZ family
F6A13_01400	COG1022	Amp-dependent synthetase and ligase
F6A13_01405	COG0625	glutathione transferase activity
F6A13_01410	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F6A13_01420	COG0653	protein targeting
F6A13_01425	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F6A13_01430	COG0494	nUDIX hydrolase
F6A13_01435	COG0463	Glycosyl transferase, family 2
F6A13_01445	COG0297	glycogen (starch) synthase activity
F6A13_01465	COG0463	Glycosyl transferase, family 2
F6A13_01470	COG0859	PFAM glycosyl transferase family 9
F6A13_01480	COG1519	Transferase
F6A13_01485	COG1560	Kdo2-lipid A biosynthetic process
F6A13_01490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F6A13_01495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F6A13_01500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F6A13_01505	COG1040	competence protein
F6A13_01510	COG0156	8-amino-7-oxononanoate synthase activity
F6A13_01525	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F6A13_01535	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F6A13_01540	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
F6A13_01545	COG0390	transport system, permease component
F6A13_01555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F6A13_01555	COG0543	2 iron, 2 sulfur cluster binding
F6A13_01575	COG1309	transcriptional regulator
F6A13_01580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F6A13_01585	COG1566	PFAM secretion protein HlyD family protein
F6A13_01595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F6A13_01600	COG1872	DUF167
F6A13_01650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F6A13_01655	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F6A13_01660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F6A13_01665	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F6A13_01685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F6A13_01705	COG0735	belongs to the Fur family
F6A13_01710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F6A13_01715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F6A13_01720	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F6A13_01725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F6A13_01730	COG1671	Belongs to the UPF0178 family
F6A13_01765	COG0659	secondary active sulfate transmembrane transporter activity
F6A13_01770	COG0288	reversible hydration of carbon dioxide
F6A13_01775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F6A13_01780	COG2226	methyltransferase
F6A13_01790	COG2813	Specifically methylates the guanine in position
F6A13_01790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F6A13_01795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F6A13_01805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F6A13_01810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F6A13_01815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F6A13_01815	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F6A13_01830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F6A13_01835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F6A13_01855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F6A13_01880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F6A13_01900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F6A13_01905	COG0081	regulation of translation
F6A13_01910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F6A13_01915	COG0222	ribosome binding
F6A13_01920	COG0085	RNA polymerase activity
F6A13_01925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F6A13_01930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F6A13_01935	COG0049	tRNA binding
F6A13_01940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F6A13_01945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F6A13_01950	COG0051	transcription antitermination factor activity, RNA binding
F6A13_01955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F6A13_01960	COG0088	Forms part of the polypeptide exit tunnel
F6A13_01965	COG0089	rRNA binding
F6A13_01970	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F6A13_01975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F6A13_01980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F6A13_01990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F6A13_01995	COG0255	Belongs to the universal ribosomal protein uL29 family
F6A13_02000	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F6A13_02005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F6A13_02010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F6A13_02015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F6A13_02020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F6A13_02025	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F6A13_02030	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F6A13_02035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F6A13_02040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F6A13_02045	COG1841	ribosomal large subunit assembly
F6A13_02050	COG0200	Binds to the 23S rRNA
F6A13_02055	COG0201	protein transport
F6A13_02060	COG0563	adenylate kinase activity
F6A13_02065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F6A13_02070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F6A13_02075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F6A13_02080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F6A13_02085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F6A13_02090	COG0202	RNA polymerase activity
F6A13_02095	COG0203	ribosomal protein L17
F6A13_02100	COG0756	dUTP diphosphatase activity
F6A13_02105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F6A13_02110	COG2003	Belongs to the UPF0758 family
F6A13_02120	COG0671	phosphoesterase, PA-phosphatase related
F6A13_02155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F6A13_02155	COG0678	peroxiredoxin activity
F6A13_02160	COG0560	Phosphoserine phosphatase
F6A13_02165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F6A13_02170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F6A13_02175	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F6A13_02180	COG0585	pseudouridine synthase activity
F6A13_02185	COG0789	Transcriptional regulator
F6A13_02195	COG0492	ferredoxin-NADP+ reductase activity
F6A13_02205	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F6A13_02215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F6A13_02220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F6A13_02230	COG1376	ErfK ybiS ycfS ynhG family protein
F6A13_02265	COG0779	Required for maturation of 30S ribosomal subunits
F6A13_02270	COG0195	Participates in both transcription termination and antitermination
F6A13_02275	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F6A13_02280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F6A13_02285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F6A13_02290	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F6A13_02295	COG1185	polyribonucleotide nucleotidyltransferase activity
F6A13_02300	COG0612	Peptidase, M16
F6A13_02305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F6A13_02315	COG0328	RNA-DNA hybrid ribonuclease activity
F6A13_02320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F6A13_02340	COG0137	argininosuccinate synthase activity
F6A13_02345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F6A13_02350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F6A13_02355	COG0527	aspartate kinase activity
F6A13_02385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F6A13_02395	COG0741	lytic transglycosylase activity
F6A13_02395	COG1388	LysM domain
F6A13_02400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F6A13_02425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F6A13_02430	COG0538	isocitrate dehydrogenase activity
F6A13_02435	COG0045	succinate-CoA ligase (ADP-forming) activity
F6A13_02445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F6A13_02450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F6A13_02450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F6A13_02480	COG1850	ribulose-bisphosphate carboxylase activity
F6A13_02485	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
F6A13_02490	COG0235	Class ii aldolase
F6A13_02500	COG0242	peptide deformylase activity
F6A13_02505	COG0531	amino acid
F6A13_02530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F6A13_02540	COG2204	response regulator
F6A13_02550	COG2205	protein histidine kinase activity
F6A13_02555	COG0497	DNA recombination
F6A13_02560	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F6A13_02565	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F6A13_02570	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F6A13_02570	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F6A13_02575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F6A13_02585	COG1466	dna polymerase III delta subunit
F6A13_02595	COG0495	leucyl-tRNA aminoacylation
F6A13_02600	COG0655	NAD(P)H dehydrogenase (quinone) activity
F6A13_02605	COG2353	YceI-like domain
F6A13_02610	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
F6A13_02615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F6A13_02625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F6A13_02640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F6A13_02645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F6A13_02660	COG0436	Aminotransferase
F6A13_02670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F6A13_02680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F6A13_02690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F6A13_02700	COG1136	(ABC) transporter
F6A13_02710	COG0658	competence protein
F6A13_02710	COG2333	competence protein COMEC
F6A13_02715	COG0811	peptide transport
F6A13_02720	COG0848	biopolymer transport protein
F6A13_02735	COG1663	tetraacyldisaccharide 4'-kinase activity
F6A13_02740	COG2835	tetraacyldisaccharide 4'-kinase activity
F6A13_02745	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F6A13_02785	COG1942	4-Oxalocrotonate Tautomerase
F6A13_02795	COG4372	Transposase
F6A13_02860	COG1573	uracil-dna glycosylase
F6A13_02865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F6A13_02870	COG0542	response to heat
F6A13_02875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F6A13_02880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F6A13_02885	COG0693	protein deglycase activity
F6A13_02890	COG0793	Belongs to the peptidase S41A family
F6A13_02900	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F6A13_02905	COG0058	SHG alpha-glucan phosphorylase activity
F6A13_02915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F6A13_02930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F6A13_02935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F6A13_02960	COG2046	Belongs to the sulfate adenylyltransferase family
F6A13_02960	COG0529	Catalyzes the synthesis of activated sulfate
F6A13_02970	COG0459	protein refolding
F6A13_02975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F6A13_02985	COG4232	protein-disulfide reductase activity
F6A13_03000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F6A13_03010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F6A13_03030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F6A13_03035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F6A13_03040	COG0196	riboflavin kinase activity
F6A13_03060	COG1561	YicC-like family, N-terminal region
F6A13_03065	COG0194	GDP metabolic process
F6A13_03070	COG1758	RNA polymerase activity
F6A13_03075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F6A13_03105	COG0628	permease
F6A13_03110	COG1355	regulation of microtubule-based process
F6A13_03115	COG2078	PFAM AMMECR1 domain protein
F6A13_03125	COG1538	Outer membrane efflux protein
F6A13_03185	COG2203	Gaf domain
F6A13_03185	COG4251	negative regulation of phosphorylation
F6A13_03185	COG3706	GGDEF domain
F6A13_03185	COG5001	Diguanylate cyclase
F6A13_03210	COG1850	ribulose-bisphosphate carboxylase activity
F6A13_03265	COG1192	Involved in chromosome partitioning
F6A13_03290	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F6A13_03295	COG0009	L-threonylcarbamoyladenylate synthase
F6A13_03300	COG0129	dihydroxy-acid dehydratase activity
F6A13_03305	COG0418	dihydroorotase activity
F6A13_03330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F6A13_03335	COG3002	Belongs to the UPF0753 family
F6A13_03375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F6A13_03460	COG5377	YqaJ viral recombinase family
F6A13_03495	COG4372	Transposase
F6A13_03525	COG0305	Participates in initiation and elongation during chromosome replication
F6A13_03535	COG2944	sequence-specific DNA binding
F6A13_03655	COG1192	Involved in chromosome partitioning
F6A13_03710	COG0776	regulation of translation
F6A13_03750	COG0513	Belongs to the DEAD box helicase family
F6A13_03755	COG1278	Cold shock
F6A13_03760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F6A13_03775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F6A13_03785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F6A13_03790	COG1702	phosphate starvation-inducible protein PhoH
F6A13_03795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F6A13_03800	COG4535	Mg2 and Co2 transporter CorC
F6A13_03805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F6A13_03810	COG0312	modulator of DNA gyrase
F6A13_03820	COG1121	(ABC) transporter
F6A13_03830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F6A13_03875	COG0438	transferase activity, transferring glycosyl groups
F6A13_03880	COG0438	transferase activity, transferring glycosyl groups
F6A13_03885	COG1132	(ABC) transporter
F6A13_03890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F6A13_03900	COG0406	alpha-ribazole phosphatase activity
F6A13_03900	COG0328	RNA-DNA hybrid ribonuclease activity
F6A13_03915	COG2226	methyltransferase
F6A13_03920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F6A13_03930	COG0066	3-isopropylmalate dehydratase activity
F6A13_03940	COG0259	pyridoxamine-phosphate oxidase activity
F6A13_03945	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F6A13_03960	COG1271	oxidase subunit
F6A13_03990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F6A13_03995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F6A13_04010	COG0109	protoheme IX farnesyltransferase activity
F6A13_04015	COG2814	Major facilitator Superfamily
F6A13_04020	COG1968	undecaprenyl-diphosphatase activity
F6A13_04025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F6A13_04035	COG0505	Belongs to the CarA family
F6A13_04050	COG2022	thiamine diphosphate biosynthetic process
F6A13_04060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F6A13_04065	COG0163	prenyltransferase activity
F6A13_04070	COG1127	ABC transporter
F6A13_04075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F6A13_04095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F6A13_04110	COG1136	(ABC) transporter
F6A13_04130	COG0254	rRNA binding
F6A13_04135	COG0281	malic enzyme
F6A13_04140	COG0628	permease
F6A13_04145	COG0129	dihydroxy-acid dehydratase activity
F6A13_04155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F6A13_04155	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F6A13_04160	COG0271	Belongs to the BolA IbaG family
F6A13_04165	COG2350	Protein conserved in bacteria
F6A13_04170	COG2917	probably involved in intracellular septation
F6A13_04185	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
F6A13_04195	COG1959	2 iron, 2 sulfur cluster binding
F6A13_04200	COG1104	cysteine desulfurase activity
F6A13_04205	COG0822	iron-sulfur transferase activity
F6A13_04220	COG0443	Heat shock 70 kDa protein
F6A13_04235	COG0482	sulfurtransferase activity
F6A13_04240	COG1752	Esterase of the alpha-beta hydrolase superfamily
F6A13_04265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F6A13_04290	COG3791	Glutathione-dependent formaldehyde-activating
F6A13_04295	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F6A13_04300	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F6A13_04305	COG0583	DNA-binding transcription factor activity
F6A13_04310	COG2204	response regulator
F6A13_04360	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F6A13_04380	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F6A13_04420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F6A13_04450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F6A13_04455	COG0493	'glutamate synthase
F6A13_04460	COG0067	glutamate synthase
F6A13_04460	COG0070	glutamate synthase
F6A13_04460	COG0069	glutamate synthase activity
F6A13_04465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F6A13_04470	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
F6A13_04475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F6A13_04480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F6A13_04510	COG0590	tRNA wobble adenosine to inosine editing
F6A13_04515	COG0432	Pfam Uncharacterised protein family UPF0047
F6A13_04525	COG1193	negative regulation of DNA recombination
F6A13_04530	COG0028	Belongs to the TPP enzyme family
F6A13_04540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F6A13_04545	COG0688	phosphatidylethanolamine metabolic process
F6A13_04550	COG1183	phosphatidylcholine synthase activity
F6A13_04560	COG0589	response to stress
F6A13_04565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F6A13_04570	COG1196	nuclear chromosome segregation
F6A13_04585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F6A13_04620	COG0730	response to heat
F6A13_04625	COG0811	peptide transport
F6A13_04645	COG0402	S-adenosylhomocysteine deaminase activity
F6A13_04650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F6A13_04685	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F6A13_04685	COG3608	succinylglutamate desuccinylase aspartoacylase
F6A13_04705	COG0746	molybdenum cofactor guanylyltransferase activity
F6A13_04755	COG0475	glutathione-regulated potassium exporter activity
F6A13_04760	COG1028	Short-chain dehydrogenase reductase Sdr
F6A13_04840	COG2814	Major facilitator Superfamily
F6A13_04845	COG0038	chloride channel
F6A13_04860	COG2217	Heavy metal translocating P-type atpase
F6A13_04860	COG2217	Heavy metal translocating P-type atpase
F6A13_04880	COG4654	Cytochrome c, class I
F6A13_04905	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F6A13_04910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F6A13_04920	COG0583	DNA-binding transcription factor activity
F6A13_04965	COG0477	Major facilitator Superfamily
F6A13_04975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F6A13_04975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F6A13_04990	COG2154	pterin-4-alpha-carbinolamine dehydratase
F6A13_05005	COG1064	alcohol dehydrogenase
F6A13_05010	COG0504	CTP synthase activity
F6A13_05015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F6A13_05020	COG0148	phosphopyruvate hydratase activity
F6A13_05025	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F6A13_05030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F6A13_05040	COG0322	excinuclease ABC activity
F6A13_05075	COG1648	precorrin-2 dehydrogenase activity
F6A13_05075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F6A13_05080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F6A13_05085	COG0243	molybdopterin cofactor binding
F6A13_05090	COG2146	nitrite reductase [NAD(P)H] activity
F6A13_05095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F6A13_05105	COG2223	nitrite transmembrane transporter activity
F6A13_05110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F6A13_05110	COG1116	anion transmembrane transporter activity
F6A13_05120	COG3189	MarR family transcriptional regulator
F6A13_05135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F6A13_05135	COG1017	nitric oxide dioxygenase activity
F6A13_05140	COG1566	PFAM secretion protein HlyD family protein
F6A13_05145	COG1538	Outer membrane efflux protein
F6A13_05150	COG2814	Major facilitator Superfamily
F6A13_05155	COG0583	DNA-binding transcription factor activity
F6A13_05205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F6A13_05215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F6A13_05220	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F6A13_05230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F6A13_05235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F6A13_05245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F6A13_05250	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F6A13_05255	COG0287	Prephenate dehydrogenase
F6A13_05260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F6A13_05265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F6A13_05275	COG0776	regulation of translation
F6A13_05280	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F6A13_05285	COG0284	orotidine-5'-phosphate decarboxylase activity
F6A13_05290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F6A13_05295	COG0544	peptidyl-prolyl cis-trans isomerase activity
F6A13_05300	COG0740	serine-type endopeptidase activity
F6A13_05305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F6A13_05310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F6A13_05330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F6A13_05360	COG2915	High frequency lysogenization protein hflD homolog
F6A13_05365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F6A13_05370	COG0024	Methionine aminopeptidase
F6A13_05375	COG1489	DNA binding
F6A13_05380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F6A13_05390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F6A13_05395	COG1546	Belongs to the CinA family
F6A13_05395	COG1058	Belongs to the CinA family
F6A13_05400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F6A13_05405	COG2137	regulation of response to DNA damage stimulus
F6A13_05445	COG0739	heme binding
F6A13_05445	COG0741	lytic transglycosylase activity
F6A13_05445	COG1196	nuclear chromosome segregation
F6A13_05450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F6A13_05465	COG0488	(ABC) transporter
F6A13_05470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F6A13_05495	COG1294	oxidase, subunit
F6A13_05500	COG1271	oxidase subunit
F6A13_05515	COG0400	carboxylic ester hydrolase activity
F6A13_05520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F6A13_05525	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
F6A13_05535	COG3416	Protein conserved in bacteria
F6A13_05535	COG2943	transferase activity, transferring hexosyl groups
F6A13_05545	COG2363	Small membrane protein
F6A13_05555	COG0616	signal peptide processing
F6A13_05560	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F6A13_05565	COG0314	molybdopterin synthase activity
F6A13_05570	COG1666	GTP binding
F6A13_05580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F6A13_05585	COG0509	glycine decarboxylation via glycine cleavage system
F6A13_05590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F6A13_05595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F6A13_05600	COG1132	(ABC) transporter
F6A13_05605	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F6A13_05610	COG0450	alkyl hydroperoxide reductase
F6A13_05620	COG0613	PHP domain protein
F6A13_05625	COG0628	permease
F6A13_05645	COG0084	hydrolase, TatD family'
F6A13_05650	COG0321	lipoyl(octanoyl) transferase activity
F6A13_05650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F6A13_05665	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F6A13_05675	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F6A13_05690	COG2353	YceI-like domain
F6A13_05700	COG1846	Transcriptional regulator
F6A13_05715	COG4988	ABC transporter
F6A13_05720	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F6A13_05730	COG0354	folic acid binding
F6A13_05740	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F6A13_05755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F6A13_05760	COG0481	GTPase activity
F6A13_05765	COG0681	Belongs to the peptidase S26 family
F6A13_05775	COG0571	ribonuclease III activity
F6A13_05780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F6A13_05785	COG1381	Involved in DNA repair and RecF pathway recombination
F6A13_05790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F6A13_05795	COG0736	holo-[acyl-carrier-protein] synthase activity
F6A13_05805	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F6A13_05805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F6A13_05810	COG0037	tRNA processing
F6A13_05815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F6A13_05835	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
F6A13_05845	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F6A13_05895	COG1230	cation diffusion facilitator family transporter
F6A13_05910	COG0513	Belongs to the DEAD box helicase family
F6A13_05925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F6A13_05930	COG0573	inorganic phosphate transmembrane transporter activity
F6A13_05935	COG0581	inorganic phosphate transmembrane transporter activity
F6A13_05940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F6A13_05945	COG0704	Plays a role in the regulation of phosphate uptake
F6A13_05960	COG0052	Belongs to the universal ribosomal protein uS2 family
F6A13_05965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F6A13_05970	COG0528	UMP kinase activity
F6A13_05980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F6A13_05985	COG0575	Belongs to the CDS family
F6A13_05990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F6A13_06010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6A13_06015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F6A13_06020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6A13_06025	COG0673	inositol 2-dehydrogenase activity
F6A13_06035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6A13_06050	COG0825	malonyl-CoA metabolic process
F6A13_06055	COG0037	tRNA processing
F6A13_06065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F6A13_06070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F6A13_06080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F6A13_06085	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F6A13_06090	COG1166	arginine decarboxylase activity
F6A13_06125	COG3411	Ferredoxin
F6A13_06140	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F6A13_06170	COG0811	peptide transport
F6A13_06190	COG0725	ABC transporter, periplasmic molybdate-binding protein
F6A13_06200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F6A13_06295	COG5420	small protein containing a coiled-coil domain
F6A13_06310	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F6A13_06315	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F6A13_06370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F6A13_06375	COG0316	Belongs to the HesB IscA family
F6A13_06395	COG5554	nitrogen fixation
F6A13_06410	COG5554	nitrogen fixation
F6A13_06425	COG0633	Ferredoxin
F6A13_06450	COG1012	belongs to the aldehyde dehydrogenase family
F6A13_06470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F6A13_06475	COG0438	transferase activity, transferring glycosyl groups
F6A13_06480	COG0438	transferase activity, transferring glycosyl groups
F6A13_06485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F6A13_06500	COG4974	Belongs to the 'phage' integrase family
F6A13_06535	COG1484	DNA-dependent DNA replication
F6A13_06550	COG0629	single-stranded DNA binding
F6A13_06570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F6A13_06575	COG1061	Type III restriction enzyme res subunit
F6A13_06585	COG1002	Type II restriction enzyme, methylase subunits
F6A13_06610	COG0776	regulation of translation
F6A13_06615	COG0776	regulation of translation
F6A13_06640	COG3077	Addiction module antitoxin, RelB DinJ family
F6A13_06765	COG4372	Transposase
F6A13_06785	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F6A13_06800	COG4962	Type ii secretion system protein e
F6A13_06820	COG3451	type IV secretory pathway VirB4
F6A13_06860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F6A13_06875	COG2084	Dehydrogenase
F6A13_06880	COG0243	molybdopterin cofactor binding
F6A13_06890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F6A13_06900	COG0633	Ferredoxin
F6A13_06900	COG0543	2 iron, 2 sulfur cluster binding
F6A13_06905	COG1151	hydroxylamine reductase activity
F6A13_06920	COG3002	Belongs to the UPF0753 family
F6A13_06925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F6A13_06930	COG0247	lactate metabolic process
F6A13_06935	COG0277	FAD linked oxidase domain protein
F6A13_06940	COG0277	FAD linked oxidase domain protein
F6A13_06975	COG0418	dihydroorotase activity
F6A13_06980	COG0129	dihydroxy-acid dehydratase activity
F6A13_06985	COG0009	L-threonylcarbamoyladenylate synthase
F6A13_06990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F6A13_06995	COG0191	fructose-bisphosphate aldolase activity
F6A13_07015	COG1192	Involved in chromosome partitioning
F6A13_07070	COG1850	ribulose-bisphosphate carboxylase activity
F6A13_07085	COG3701	Conjugal transfer protein
F6A13_07145	COG5001	Diguanylate cyclase
F6A13_07145	COG3300	MHYT domain
F6A13_07175	COG1475	DNA binding
F6A13_07180	COG1192	Involved in chromosome partitioning
F6A13_07195	COG0667	Aldo Keto reductase
F6A13_07245	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F6A13_07250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F6A13_07275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F6A13_07285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F6A13_07310	COG0438	transferase activity, transferring glycosyl groups
F6A13_07315	COG0670	Belongs to the BI1 family
F6A13_07340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F6A13_07345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F6A13_07350	COG1428	Deoxynucleoside kinase
F6A13_07360	COG0617	tRNA 3'-terminal CCA addition
F6A13_07370	COG0463	Glycosyl transferase, family 2
F6A13_07380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F6A13_07380	COG0519	Catalyzes the synthesis of GMP from XMP
F6A13_07385	COG0531	amino acid
F6A13_07390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F6A13_07395	COG3264	Mechanosensitive ion channel
F6A13_07395	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F6A13_07410	COG0009	L-threonylcarbamoyladenylate synthase
F6A13_07415	COG1994	Peptidase M50
F6A13_07420	COG0180	Tryptophanyl-tRNA synthetase
F6A13_07425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F6A13_07430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F6A13_07435	COG0446	pyridine nucleotide-disulphide oxidoreductase
F6A13_07440	COG1187	pseudouridine synthase activity
F6A13_07445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F6A13_07460	COG2814	Major facilitator Superfamily
F6A13_07500	COG1105	Belongs to the carbohydrate kinase PfkB family
F6A13_07505	COG0280	phosphate acetyltransferase
F6A13_07510	COG0477	Major facilitator Superfamily
F6A13_07515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F6A13_07520	COG0508	dehydrogenase complex catalyzes the overall conversion of
F6A13_07525	COG0022	dehydrogenase e1 component
F6A13_07530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F6A13_07540	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F6A13_07545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F6A13_07545	COG0574	Belongs to the PEP-utilizing enzyme family
F6A13_07560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F6A13_07565	COG2171	N-acyltransferase activity
F6A13_07580	COG0546	phosphoglycolate phosphatase activity
F6A13_07585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F6A13_07590	COG0402	S-adenosylhomocysteine deaminase activity
F6A13_07600	COG0791	NLP P60 protein
F6A13_07645	COG0732	type I restriction modification DNA specificity domain
F6A13_07680	COG0596	Alpha beta hydrolase
F6A13_07695	COG3153	acetyltransferase
F6A13_07750	COG4372	Transposase
F6A13_07785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F6A13_07800	COG0587	DNA-directed DNA polymerase activity
F6A13_07810	COG0308	aminopeptidase N
F6A13_07825	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F6A13_07830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F6A13_07835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6A13_07840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6A13_07855	COG0424	maF-like protein
F6A13_07860	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F6A13_07865	COG1923	regulation of RNA biosynthetic process
F6A13_07870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F6A13_07875	COG0330	HflC and HflK could
F6A13_07880	COG0330	HflC and HflK could
F6A13_07885	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
F6A13_07910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F6A13_07915	COG1546	Belongs to the CinA family
F6A13_07915	COG1058	Belongs to the CinA family
F6A13_07920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F6A13_07925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F6A13_07935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F6A13_07940	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F6A13_07955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F6A13_07960	COG0416	fatty acid biosynthetic process
F6A13_07965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F6A13_07970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F6A13_07980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F6A13_07985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F6A13_07995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F6A13_08000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F6A13_08030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F6A13_08035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F6A13_08040	COG0004	ammonium transporteR
F6A13_08045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F6A13_08045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F6A13_08050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F6A13_08060	COG0802	atpase or kinase
F6A13_08065	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F6A13_08070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F6A13_08075	COG0105	UTP biosynthetic process
F6A13_08080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F6A13_08090	COG1426	Protein conserved in bacteria
F6A13_08095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F6A13_08100	COG0124	histidyl-tRNA synthetase
F6A13_08115	COG1160	GTP binding
F6A13_08155	COG0730	response to heat
F6A13_08240	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6A13_08255	COG1881	PFAM PEBP family protein
F6A13_08260	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F6A13_08280	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
F6A13_08285	COG1216	Glycosyl transferase, family 2
F6A13_08310	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F6A13_08315	COG1028	Short-chain dehydrogenase reductase Sdr
F6A13_08350	COG0729	surface antigen
F6A13_08370	COG4654	Cytochrome c, class I
F6A13_08395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F6A13_08405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F6A13_08420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F6A13_08425	COG1469	GTP cyclohydrolase I activity
F6A13_08430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F6A13_08435	COG0142	geranyltranstransferase activity
F6A13_08445	COG2223	nitrite transmembrane transporter activity
F6A13_08455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F6A13_08460	COG1570	exodeoxyribonuclease VII activity
F6A13_08465	COG2010	Cytochrome c
F6A13_08465	COG4993	Dehydrogenase
F6A13_08475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F6A13_08480	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6A13_08485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F6A13_08490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F6A13_08510	COG0583	DNA-binding transcription factor activity
F6A13_08515	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F6A13_08525	COG2197	response regulator
F6A13_08535	COG3916	Acyl-homoserine-lactone synthase
F6A13_08585	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F6A13_08590	COG0456	acetyltransferase
F6A13_08620	COG1132	(ABC) transporter
F6A13_08625	COG2217	Heavy metal translocating P-type atpase
F6A13_08640	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F6A13_08645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F6A13_08650	COG0640	Transcriptional regulator
F6A13_08655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F6A13_08670	COG0187	DNA topoisomerase II activity
F6A13_08675	COG0642	Histidine kinase
F6A13_08680	COG0745	RESPONSE REGULATOR receiver
F6A13_08780	COG4968	Prepilin-type N-terminal cleavage methylation domain
F6A13_08860	COG3093	addiction module antidote protein HigA
F6A13_08875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F6A13_08880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F6A13_08885	COG1862	Preprotein translocase
F6A13_08890	COG0343	queuine tRNA-ribosyltransferase activity
F6A13_08895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F6A13_08900	COG1253	flavin adenine dinucleotide binding
F6A13_08915	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F6A13_08925	COG0285	dihydrofolate synthase activity
F6A13_08930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F6A13_08935	COG0159	tryptophan synthase activity
F6A13_08940	COG0133	tryptophan synthase activity
F6A13_08945	COG0135	phosphoribosylanthranilate isomerase activity
F6A13_08950	COG0101	tRNA pseudouridine synthase activity
F6A13_08960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F6A13_08970	COG0746	molybdenum cofactor guanylyltransferase activity
F6A13_08975	COG1763	Mo-molybdopterin cofactor biosynthetic process
F6A13_08980	COG0303	'Molybdopterin
F6A13_08985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F6A13_08990	COG0616	signal peptide processing
F6A13_09070	COG2226	methyltransferase
F6A13_09085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F6A13_09090	COG0154	amidase activity
F6A13_09095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F6A13_09130	COG3394	polysaccharide catabolic process
F6A13_09145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F6A13_09150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F6A13_09155	COG1657	PFAM Prenyltransferase squalene oxidase
F6A13_09160	COG1562	ergosterol biosynthetic process
F6A13_09165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F6A13_09170	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F6A13_09185	COG0442	prolyl-tRNA aminoacylation
F6A13_09205	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F6A13_09220	COG1692	metallophosphoesterase
F6A13_09225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F6A13_09245	COG0768	penicillin binding
F6A13_09250	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F6A13_09255	COG0193	aminoacyl-tRNA hydrolase activity
F6A13_09260	COG0012	GTP binding
F6A13_09265	COG1396	sequence-specific DNA binding
F6A13_09270	COG0651	ATP synthesis coupled electron transport
F6A13_09275	COG0650	Formate hydrogenlyase subunit 4
F6A13_09285	COG0651	ATP synthesis coupled electron transport
F6A13_09290	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
F6A13_09290	COG3261	NADH dehydrogenase
F6A13_09295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6A13_09300	COG1850	ribulose-bisphosphate carboxylase activity
F6A13_09320	COG2824	Alkylphosphonate utilization operon protein PhnA
F6A13_09330	COG0726	polysaccharide deacetylase
F6A13_09330	COG1649	PFAM Uncharacterised BCR, COG1649
F6A13_09340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F6A13_09345	COG0494	nUDIX hydrolase
F6A13_09355	COG1187	pseudouridine synthase activity
F6A13_09360	COG2957	Belongs to the agmatine deiminase family
F6A13_09365	COG0243	molybdopterin cofactor binding
F6A13_09395	COG0210	DNA helicase
F6A13_09400	COG0268	Binds directly to 16S ribosomal RNA
F6A13_09405	COG3842	ATPase activity
F6A13_09420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F6A13_09425	COG0514	ATP-dependent DNA helicase (RecQ)
F6A13_09430	COG1965	Belongs to the frataxin family
F6A13_09450	COG0795	lipopolysaccharide-transporting ATPase activity
F6A13_09455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F6A13_09470	COG0525	valine-tRNA ligase activity
F6A13_09475	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F6A13_09495	COG0412	Dienelactone hydrolase
F6A13_09500	COG1902	pentaerythritol trinitrate reductase activity
F6A13_09515	COG3152	Membrane
F6A13_09535	COG0546	phosphoglycolate phosphatase activity
F6A13_09545	COG1530	ribonuclease E activity
F6A13_09550	COG0215	cysteine-tRNA ligase activity
F6A13_09555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F6A13_09575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F6A13_09580	COG0745	RESPONSE REGULATOR receiver
F6A13_09585	COG2205	protein histidine kinase activity
F6A13_09595	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F6A13_09600	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F6A13_09605	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F6A13_09610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F6A13_09620	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F6A13_09690	COG0138	bifunctional purine biosynthesis protein purh
F6A13_09695	COG0151	Belongs to the GarS family
F6A13_09700	COG0009	L-threonylcarbamoyladenylate synthase
F6A13_09705	COG0408	coproporphyrinogen oxidase activity
F6A13_09710	COG0167	dihydroorotate dehydrogenase activity
F6A13_09735	COG0811	peptide transport
F6A13_09775	COG2814	Major facilitator Superfamily
F6A13_09780	COG2062	phosphohistidine phosphatase, SixA
F6A13_09795	COG2205	protein histidine kinase activity
F6A13_09800	COG0745	RESPONSE REGULATOR receiver
F6A13_09805	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F6A13_09810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F6A13_09825	COG0033	Phosphoglucomutase
F6A13_09840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F6A13_09845	COG3038	cytochrome b561
F6A13_09855	COG2814	Major facilitator Superfamily
F6A13_09860	COG0583	DNA-binding transcription factor activity
F6A13_09880	COG1193	negative regulation of DNA recombination
F6A13_09890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F6A13_09900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F6A13_09905	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F6A13_09920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F6A13_09940	COG1686	Belongs to the peptidase S11 family
F6A13_09985	COG4372	Transposase
F6A13_10010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F6A13_10015	COG3273	potassium ion transport
F6A13_10015	COG0471	metal ion transport
F6A13_10025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F6A13_10035	COG0583	DNA-binding transcription factor activity
F6A13_10040	COG2210	Belongs to the sulfur carrier protein TusA family
F6A13_10090	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F6A13_10095	COG1215	transferase activity, transferring glycosyl groups
F6A13_10100	COG1215	transferase activity, transferring glycosyl groups
F6A13_10110	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
F6A13_10155	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F6A13_10160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F6A13_10170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F6A13_10180	COG1272	protein, Hemolysin III
F6A13_10185	COG0860	N-Acetylmuramoyl-L-alanine amidase
F6A13_10195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F6A13_10200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F6A13_10215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6A13_10225	COG0640	Transcriptional regulator
F6A13_10235	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F6A13_10250	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F6A13_10255	COG0084	hydrolase, TatD family'
F6A13_10260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6A13_10265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6A13_10310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F6A13_10315	COG4974	Belongs to the 'phage' integrase family
F6A13_10370	COG0454	-acetyltransferase
F6A13_10375	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6A13_10420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F6A13_10450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F6A13_10465	COG5001	Diguanylate cyclase
F6A13_10490	COG1846	Transcriptional regulator
F6A13_10500	COG2353	YceI-like domain
F6A13_10530	COG0776	regulation of translation
F6A13_10535	COG0776	regulation of translation
F6A13_10550	COG0393	Putative heavy-metal-binding
F6A13_10555	COG0477	Major facilitator Superfamily
F6A13_10570	COG0811	peptide transport
F6A13_10635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F6A13_10650	COG1013	pyruvate-flavodoxin oxidoreductase activity
F6A13_10670	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F6A13_10685	COG3012	SEC-C Motif Domain Protein
F6A13_10700	COG0670	Belongs to the BI1 family
F6A13_10705	COG1733	regulation of RNA biosynthetic process
F6A13_10710	COG0625	glutathione transferase activity
F6A13_10785	COG1230	cation diffusion facilitator family transporter
F6A13_10835	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6A13_10900	COG2217	Heavy metal translocating P-type atpase
F6A13_10910	COG4654	Cytochrome c, class I
F6A13_10930	COG0531	amino acid
F6A13_10950	COG0347	Belongs to the P(II) protein family
F6A13_10960	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F6A13_10965	COG0189	ligase activity
F6A13_10965	COG0569	domain protein
F6A13_10970	COG0456	acetyltransferase
F6A13_10985	COG4372	Transposase
F6A13_11005	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F6A13_11010	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F6A13_11015	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F6A13_11025	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F6A13_11055	COG0789	Transcriptional regulator
F6A13_11200	COG1199	ATP-dependent helicase activity
F6A13_11215	COG0791	NLP P60 protein
F6A13_11245	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F6A13_11250	COG0586	Pfam SNARE associated Golgi protein
F6A13_11280	COG0123	including yeast histone deacetylase and acetoin utilization protein
F6A13_11330	COG0644	oxidoreductase
F6A13_11335	COG0095	Lipoate-protein ligase
F6A13_11345	COG0509	glycine decarboxylation via glycine cleavage system
F6A13_11355	COG0509	glycine decarboxylation via glycine cleavage system
F6A13_11360	COG2048	Heterodisulfide reductase, subunit B
F6A13_11390	COG2210	Belongs to the sulfur carrier protein TusA family
F6A13_11395	COG0425	Belongs to the sulfur carrier protein TusA family
F6A13_11400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F6A13_11405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F6A13_11415	COG0315	cyclic pyranopterin monophosphate synthase activity
F6A13_11420	COG1077	Cell shape determining protein MreB Mrl
F6A13_11425	COG1792	Involved in formation and maintenance of cell shape
F6A13_11435	COG0768	penicillin binding
F6A13_11440	COG0772	Belongs to the SEDS family
F6A13_11445	COG1686	Belongs to the peptidase S11 family
F6A13_11455	COG0321	lipoyl(octanoyl) transferase activity
F6A13_11460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F6A13_11510	COG0751	glycine-tRNA ligase activity
F6A13_11515	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F6A13_11525	COG0189	ligase activity
F6A13_11545	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F6A13_11575	COG0625	glutathione transferase activity
F6A13_11580	COG1733	regulation of RNA biosynthetic process
F6A13_11585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F6A13_11700	COG4456	Virulence-associated protein
F6A13_11710	COG3344	reverse transcriptase
F6A13_11725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F6A13_11735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F6A13_11740	COG2217	Heavy metal translocating P-type atpase
F6A13_11765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6A13_11770	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6A13_11855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F6A13_11975	COG2378	regulation of single-species biofilm formation
F6A13_12065	COG1484	DNA-dependent DNA replication
F6A13_12095	COG2944	sequence-specific DNA binding
F6A13_12105	COG1476	TRANSCRIPTIONal
F6A13_12160	COG0776	regulation of translation
F6A13_12165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6A13_12165	COG0072	phenylalanine-tRNA ligase activity
F6A13_12170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F6A13_12175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F6A13_12180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F6A13_12185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F6A13_12190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F6A13_12200	COG1007	ATP synthesis coupled electron transport
F6A13_12215	COG0713	ATP synthesis coupled electron transport
F6A13_12225	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6A13_12230	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F6A13_12235	COG1034	ATP synthesis coupled electron transport
F6A13_12245	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F6A13_12250	COG0649	NAD binding
F6A13_12255	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6A13_12260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6A13_12265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6A13_12275	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F6A13_12280	COG0149	triose-phosphate isomerase activity
F6A13_12285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F6A13_12290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F6A13_12295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F6A13_12300	COG0312	modulator of DNA gyrase
F6A13_12305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F6A13_12305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F6A13_12310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F6A13_12430	COG0717	Belongs to the dCTP deaminase family
F6A13_12435	COG0489	protein tyrosine kinase activity
F6A13_12445	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F6A13_12450	COG0484	heat shock protein binding
F6A13_12455	COG0443	Heat shock 70 kDa protein
F6A13_12460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F6A13_12465	COG1420	regulation of RNA biosynthetic process
F6A13_12470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F6A13_12475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F6A13_12480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6A13_12480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6A13_12485	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F6A13_12490	COG0114	fumarate hydratase activity
F6A13_12515	COG0297	glycogen (starch) synthase activity
F6A13_12520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F6A13_12530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F6A13_12560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6A13_12615	COG4964	Belongs to the GSP D family
F6A13_12670	COG0457	Tetratricopeptide repeat
F6A13_12730	COG1028	Short-chain dehydrogenase reductase Sdr
F6A13_12735	COG0723	plastoquinol--plastocyanin reductase activity
F6A13_12740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F6A13_12745	COG2857	Cytochrome c1
F6A13_12770	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F6A13_12775	COG1534	Rna-binding protein
F6A13_12780	COG2967	ApaG domain
F6A13_12785	COG2226	methyltransferase
F6A13_12805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F6A13_12815	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F6A13_12825	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F6A13_12840	COG2177	Part of the ABC transporter FtsEX involved in
F6A13_12845	COG2884	Cell division ATP-binding protein ftsE
F6A13_12850	COG0552	protein localization to endoplasmic reticulum
F6A13_12855	COG0742	ribosomal rna small subunit methyltransferase
F6A13_12860	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F6A13_12865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F6A13_12870	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
F6A13_12875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F6A13_12880	COG2890	protein-(glutamine-N5) methyltransferase activity
F6A13_12885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F6A13_12890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F6A13_12900	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
F6A13_12905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F6A13_12915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F6A13_12940	COG2860	membrane
F6A13_12985	COG2943	transferase activity, transferring hexosyl groups
F6A13_12990	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F6A13_13055	COG0746	molybdenum cofactor guanylyltransferase activity
F6A13_13090	COG1872	DUF167
F6A13_13115	COG0148	phosphopyruvate hydratase activity
F6A13_13125	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F6A13_13145	COG3459	Glycosyltransferase 36 associated
F6A13_13180	COG0006	proline dipeptidase activity
F6A13_13195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F6A13_13200	COG0305	Participates in initiation and elongation during chromosome replication
F6A13_13205	COG0359	binds to the 23S rRNA
F6A13_13220	COG0360	Binds together with S18 to 16S ribosomal RNA
F6A13_13225	COG1472	Belongs to the glycosyl hydrolase 3 family
F6A13_13230	COG0531	amino acid
F6A13_13240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F6A13_13265	COG0363	glucosamine-6-phosphate deaminase activity
F6A13_13280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F6A13_13285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F6A13_13295	COG1449	Belongs to the glycosyl hydrolase 57 family
F6A13_13300	COG1940	carbohydrate kinase activity
F6A13_13305	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F6A13_13310	COG2733	membrane
F6A13_13320	COG0629	single-stranded DNA binding
F6A13_13335	COG3118	belongs to the thioredoxin family
F6A13_13340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F6A13_13355	COG0335	large ribosomal subunit rRNA binding
F6A13_13360	COG0336	Belongs to the RNA methyltransferase TrmD family
F6A13_13365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F6A13_13370	COG0228	four-way junction DNA binding
F6A13_13375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F6A13_13435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F6A13_13445	COG1131	(ABC) transporter
F6A13_13450	COG0842	Transport permease protein
F6A13_13455	COG0842	Transport permease protein
F6A13_13480	COG0509	glycine decarboxylation via glycine cleavage system
F6A13_13510	COG2885	chlorophyll binding
F6A13_13580	COG1573	uracil-dna glycosylase
F6A13_13625	COG0142	geranyltranstransferase activity
F6A13_13640	COG3852	Histidine kinase
F6A13_13650	COG2308	Evidence 4 Homologs of previously reported genes of
F6A13_13665	COG2766	serine protein kinase
F6A13_13670	COG0004	ammonium transporteR
F6A13_13675	COG2718	Belongs to the UPF0229 family
F6A13_13680	COG2719	SpoVR family
F6A13_13690	COG0347	Belongs to the P(II) protein family
F6A13_13695	COG0004	ammonium transporteR
F6A13_13725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F6A13_13730	COG1686	Belongs to the peptidase S11 family
F6A13_13735	COG0166	Belongs to the GPI family
F6A13_13750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F6A13_13765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F6A13_13775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F6A13_13780	COG1074	ATP-dependent DNA helicase activity
F6A13_13785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F6A13_13815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F6A13_13820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F6A13_13825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F6A13_13835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F6A13_13845	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F6A13_13860	COG0424	maF-like protein
F6A13_13865	COG1530	ribonuclease E activity
F6A13_13870	COG2204	response regulator
F6A13_13880	COG2205	protein histidine kinase activity
F6A13_13890	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
F6A13_13900	COG1596	polysaccharide export
F6A13_13930	COG0438	transferase activity, transferring glycosyl groups
F6A13_13960	COG4372	Transposase
F6A13_13970	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
F6A13_13980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F6A13_14045	COG4372	Transposase
F6A13_14075	COG3077	Addiction module antitoxin, RelB DinJ family
F6A13_14115	COG1132	(ABC) transporter
F6A13_14145	COG0444	Belongs to the ABC transporter superfamily
F6A13_14150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6A13_14155	COG0601	transmembrane transport
F6A13_14180	COG2095	MarC family integral membrane protein
F6A13_14185	COG0039	L-malate dehydrogenase activity
F6A13_14200	COG0811	peptide transport
F6A13_14205	COG0848	biopolymer transport protein
F6A13_14225	COG3321	synthase
F6A13_14225	COG1028	Short-chain dehydrogenase reductase Sdr
F6A13_14225	COG0604	alcohol dehydrogenase
F6A13_14230	COG0156	8-amino-7-oxononanoate synthase activity
F6A13_14255	COG1194	a g-specific adenine glycosylase
F6A13_14265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F6A13_14270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6A13_14280	COG1660	Displays ATPase and GTPase activities
F6A13_14285	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
F6A13_14290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6A13_14290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6A13_14290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6A13_14310	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F6A13_14320	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F6A13_14345	COG3178	'Phosphotransferase
F6A13_14350	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F6A13_14355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F6A13_14360	COG0842	Transport permease protein
F6A13_14365	COG0271	Belongs to the BolA IbaG family
F6A13_14370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F6A13_14375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F6A13_14380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F6A13_14390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F6A13_14395	COG0131	Imidazoleglycerol-phosphate dehydratase
F6A13_14400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F6A13_14405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F6A13_14410	COG0107	imidazoleglycerol-phosphate synthase activity
F6A13_14415	COG0140	phosphoribosyl-ATP diphosphatase activity
F6A13_14415	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F6A13_14420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F6A13_14425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F6A13_14430	COG0805	protein transport
F6A13_14435	COG1850	ribulose-bisphosphate carboxylase activity
F6A13_14455	COG0776	regulation of translation
F6A13_14470	COG0540	Belongs to the ATCase OTCase family
F6A13_14475	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F6A13_14480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F6A13_14485	COG1678	Uncharacterized ACR, COG1678
F6A13_14490	COG0189	ligase activity
F6A13_14505	COG0316	Belongs to the HesB IscA family
F6A13_14510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F6A13_14515	COG0022	dehydrogenase e1 component
F6A13_14515	COG0508	dehydrogenase complex catalyzes the overall conversion of
F6A13_14520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F6A13_14535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F6A13_14540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F6A13_14545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F6A13_14555	COG0778	Nitroreductase
F6A13_14590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F6A13_14595	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F6A13_14605	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F6A13_14610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F6A13_14620	COG1611	Belongs to the LOG family
F6A13_14630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F6A13_14645	COG1555	photosystem II stabilization
F6A13_14650	COG0210	DNA helicase
F6A13_14670	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F6A13_14670	COG1796	DNA polymerase
F6A13_14675	COG0326	Molecular chaperone. Has ATPase activity
F6A13_14680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F6A13_14695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F6A13_14710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F6A13_14715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F6A13_14720	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F6A13_14725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F6A13_14745	COG1475	DNA binding
F6A13_14750	COG1192	Involved in chromosome partitioning
F6A13_14755	COG0357	Ribosomal RNA small subunit methyltransferase G
F6A13_14760	COG0445	tRNA wobble uridine modification
F6A13_14775	COG0521	Mo-molybdopterin cofactor biosynthetic process
F6A13_14805	COG0655	NAD(P)H dehydrogenase (quinone) activity
F6A13_14845	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F6A13_14875	COG0732	type I restriction modification DNA specificity domain
F6A13_14885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F6A13_14910	COG0625	glutathione transferase activity
F6A13_14925	COG0393	Putative heavy-metal-binding
F6A13_14940	COG1131	(ABC) transporter
F6A13_14955	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
F6A13_14960	COG1959	2 iron, 2 sulfur cluster binding
F6A13_14970	COG0134	indole-3-glycerol-phosphate synthase activity
F6A13_14975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F6A13_14990	COG0546	phosphoglycolate phosphatase activity
F6A13_14995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F6A13_15010	COG0126	phosphoglycerate kinase activity
F6A13_15015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F6A13_15020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F6A13_15025	COG1494	fructose-1,6-bisphosphatase
F6A13_15030	COG0483	inositol monophosphate 1-phosphatase activity
F6A13_15040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F6A13_15045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F6A13_15050	COG1322	Protein conserved in bacteria
F6A13_15055	COG1970	mechanosensitive ion channel activity
F6A13_15070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6A13_15125	COG0745	RESPONSE REGULATOR receiver
F6A13_15130	COG2205	protein histidine kinase activity
F6A13_15140	COG0165	Argininosuccinate lyase
F6A13_15180	COG0247	lactate metabolic process
F6A13_15180	COG2181	nitrate reductase activity
F6A13_15185	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
F6A13_15190	COG0375	protein maturation
F6A13_15205	COG0409	Hydrogenase expression formation protein
F6A13_15220	COG0662	Cupin 2, conserved barrel domain protein
F6A13_15220	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
F6A13_15245	COG0113	porphobilinogen synthase activity
F6A13_15255	COG0181	hydroxymethylbilane synthase activity
F6A13_15265	COG0537	adenosine 5'-monophosphoramidase activity
F6A13_15270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F6A13_15275	COG0352	thiamine-phosphate diphosphorylase activity
F6A13_15280	COG0351	phosphomethylpyrimidine kinase
F6A13_15285	COG0300	oxidoreductase activity