locus-tag	class	description
MQE22_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MQE22_00010	COG0592	DNA-directed DNA polymerase activity
MQE22_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MQE22_00025	COG0493	'glutamate synthase
MQE22_00025	COG0543	2 iron, 2 sulfur cluster binding
MQE22_00045	COG4804	nuclease activity
MQE22_00055	COG2814	Major facilitator Superfamily
MQE22_00060	COG3842	ATPase activity
MQE22_00065	COG0395	ABC-type sugar transport system, permease component
MQE22_00070	COG1175	transmembrane transport
MQE22_00085	COG1172	Belongs to the binding-protein-dependent transport system permease family
MQE22_00095	COG1879	ABC-type sugar transport system periplasmic component
MQE22_00100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MQE22_00105	COG1193	negative regulation of DNA recombination
MQE22_00110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MQE22_00120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MQE22_00125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MQE22_00130	COG2376	Dihydroxyacetone kinase
MQE22_00135	COG1461	Dihydroxyacetone kinase
MQE22_00140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MQE22_00140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MQE22_00145	COG0598	Magnesium transport protein CorA
MQE22_00150	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MQE22_00155	COG2894	cell division
MQE22_00160	COG0850	regulation of cytokinetic process
MQE22_00165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MQE22_00175	COG2922	Belongs to the Smg family
MQE22_00180	COG0758	DNA mediated transformation
MQE22_00190	COG0242	peptide deformylase activity
MQE22_00195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MQE22_00200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MQE22_00200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MQE22_00205	COG5000	phosphorelay sensor kinase activity
MQE22_00210	COG2204	response regulator
MQE22_00215	COG0521	Mo-molybdopterin cofactor biosynthetic process
MQE22_00220	COG0445	tRNA wobble uridine modification
MQE22_00225	COG0357	Ribosomal RNA small subunit methyltransferase G
MQE22_00230	COG1192	Involved in chromosome partitioning
MQE22_00235	COG1475	DNA binding
MQE22_00245	COG0356	it plays a direct role in the translocation of protons across the membrane
MQE22_00255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MQE22_00260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MQE22_00265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MQE22_00270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MQE22_00285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MQE22_00295	COG0583	DNA-binding transcription factor activity
MQE22_00300	COG0477	Major facilitator Superfamily
MQE22_00310	COG1566	PFAM secretion protein HlyD family protein
MQE22_00315	COG1566	PFAM secretion protein HlyD family protein
MQE22_00325	COG3189	MarR family transcriptional regulator
MQE22_00340	COG2181	nitrate reductase activity
MQE22_00345	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MQE22_00350	COG1140	nitrate reductase beta subunit
MQE22_00355	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MQE22_00400	COG0509	glycine decarboxylation via glycine cleavage system
MQE22_00420	COG1017	nitric oxide dioxygenase activity
MQE22_00420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MQE22_00490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MQE22_00490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MQE22_00560	COG0659	secondary active sulfate transmembrane transporter activity
MQE22_00565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MQE22_00600	COG0210	DNA helicase
MQE22_00630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MQE22_00645	COG1970	mechanosensitive ion channel activity
MQE22_00650	COG1322	Protein conserved in bacteria
MQE22_00655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MQE22_00660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MQE22_00665	COG0483	inositol monophosphate 1-phosphatase activity
MQE22_00670	COG1494	fructose-1,6-bisphosphatase
MQE22_00675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MQE22_00680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MQE22_00685	COG0126	phosphoglycerate kinase activity
MQE22_00690	COG0469	pyruvate kinase activity
MQE22_00700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MQE22_00705	COG0546	phosphoglycolate phosphatase activity
MQE22_00710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MQE22_00720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MQE22_00725	COG0134	indole-3-glycerol-phosphate synthase activity
MQE22_00730	COG1765	OsmC-like protein
MQE22_00735	COG1959	2 iron, 2 sulfur cluster binding
MQE22_00740	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
MQE22_00750	COG2945	thiolester hydrolase activity
MQE22_00755	COG1131	(ABC) transporter
MQE22_00760	COG0842	Transport permease protein
MQE22_00800	COG4969	Belongs to the N-Me-Phe pilin family
MQE22_00820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MQE22_00825	COG2084	Dehydrogenase
MQE22_00830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MQE22_00845	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MQE22_00855	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MQE22_00860	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MQE22_00860	COG3264	Mechanosensitive ion channel
MQE22_00875	COG2177	Part of the ABC transporter FtsEX involved in
MQE22_00880	COG2884	Cell division ATP-binding protein ftsE
MQE22_00885	COG0552	protein localization to endoplasmic reticulum
MQE22_00890	COG0742	ribosomal rna small subunit methyltransferase
MQE22_00895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MQE22_00900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MQE22_00905	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MQE22_00910	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MQE22_00915	COG2890	protein-(glutamine-N5) methyltransferase activity
MQE22_00920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MQE22_00925	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MQE22_00935	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MQE22_00940	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MQE22_00950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MQE22_00965	COG1686	Belongs to the peptidase S11 family
MQE22_00970	COG0166	Belongs to the GPI family
MQE22_00975	COG1271	oxidase subunit
MQE22_00980	COG1294	oxidase, subunit
MQE22_00995	COG1217	gtp-binding protein TYPA
MQE22_01005	COG2967	ApaG domain
MQE22_01010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MQE22_01030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MQE22_01035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MQE22_01050	COG0436	Aminotransferase
MQE22_01060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MQE22_01070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MQE22_01075	COG2217	Heavy metal translocating P-type atpase
MQE22_01085	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MQE22_01090	COG0243	molybdopterin cofactor binding
MQE22_01100	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MQE22_01115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MQE22_01125	COG1136	(ABC) transporter
MQE22_01135	COG0658	competence protein
MQE22_01135	COG2333	competence protein COMEC
MQE22_01140	COG0811	peptide transport
MQE22_01145	COG0848	biopolymer transport protein
MQE22_01160	COG1663	tetraacyldisaccharide 4'-kinase activity
MQE22_01165	COG2835	tetraacyldisaccharide 4'-kinase activity
MQE22_01170	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MQE22_01185	COG0542	response to heat
MQE22_01190	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MQE22_01195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MQE22_01205	COG0793	Belongs to the peptidase S41A family
MQE22_01215	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MQE22_01220	COG0058	SHG alpha-glucan phosphorylase activity
MQE22_01240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MQE22_01250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MQE22_01255	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MQE22_01315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MQE22_01320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MQE22_01330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MQE22_01340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MQE22_01400	COG0438	transferase activity, transferring glycosyl groups
MQE22_01405	COG0297	glycogen (starch) synthase activity
MQE22_01410	COG0110	maltose O-acetyltransferase activity
MQE22_01415	COG0297	glycogen (starch) synthase activity
MQE22_01425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MQE22_01430	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MQE22_01460	COG1278	Cold shock
MQE22_01510	COG2204	response regulator
MQE22_01515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MQE22_01520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MQE22_01530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MQE22_01535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MQE22_01545	COG1449	Belongs to the glycosyl hydrolase 57 family
MQE22_01550	COG1940	carbohydrate kinase activity
MQE22_01555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MQE22_01565	COG2733	membrane
MQE22_01570	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MQE22_01575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MQE22_01580	COG1702	phosphate starvation-inducible protein PhoH
MQE22_01585	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MQE22_01590	COG4535	Mg2 and Co2 transporter CorC
MQE22_01595	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MQE22_01645	COG0616	signal peptide processing
MQE22_01660	COG0033	Phosphoglucomutase
MQE22_01675	COG2801	Transposase and inactivated derivatives
MQE22_01700	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MQE22_01710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MQE22_01715	COG0228	four-way junction DNA binding
MQE22_01720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MQE22_01725	COG0336	Belongs to the RNA methyltransferase TrmD family
MQE22_01730	COG0335	large ribosomal subunit rRNA binding
MQE22_01740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MQE22_01750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MQE22_01755	COG3118	belongs to the thioredoxin family
MQE22_01770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MQE22_01775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MQE22_01780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MQE22_01780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MQE22_01795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MQE22_01800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MQE22_01815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MQE22_01840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MQE22_01860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MQE22_01865	COG0081	regulation of translation
MQE22_01870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MQE22_01875	COG0222	ribosome binding
MQE22_01880	COG0085	RNA polymerase activity
MQE22_01885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MQE22_01890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MQE22_01895	COG0049	tRNA binding
MQE22_01900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MQE22_01905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MQE22_01910	COG0051	transcription antitermination factor activity, RNA binding
MQE22_01915	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MQE22_01920	COG0088	Forms part of the polypeptide exit tunnel
MQE22_01925	COG0089	rRNA binding
MQE22_01930	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MQE22_01935	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MQE22_01940	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MQE22_01945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MQE22_01950	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MQE22_01955	COG0255	Belongs to the universal ribosomal protein uL29 family
MQE22_01960	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MQE22_01965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MQE22_01970	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MQE22_01975	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MQE22_01980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MQE22_01985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MQE22_01990	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MQE22_01995	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MQE22_02000	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MQE22_02005	COG1841	ribosomal large subunit assembly
MQE22_02010	COG0200	Binds to the 23S rRNA
MQE22_02015	COG0201	protein transport
MQE22_02020	COG0563	adenylate kinase activity
MQE22_02025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MQE22_02030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MQE22_02035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MQE22_02040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MQE22_02045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MQE22_02050	COG0202	RNA polymerase activity
MQE22_02055	COG0203	ribosomal protein L17
MQE22_02065	COG0629	single-stranded DNA binding
MQE22_02080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MQE22_02105	COG2995	paraquat-inducible protein a
MQE22_02110	COG0305	Participates in initiation and elongation during chromosome replication
MQE22_02115	COG0359	binds to the 23S rRNA
MQE22_02125	COG0360	Binds together with S18 to 16S ribosomal RNA
MQE22_02130	COG1472	Belongs to the glycosyl hydrolase 3 family
MQE22_02135	COG0531	amino acid
MQE22_02145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MQE22_02170	COG0363	glucosamine-6-phosphate deaminase activity
MQE22_02175	COG0330	HflC and HflK could
MQE22_02185	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MQE22_02190	COG0805	protein transport
MQE22_02195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MQE22_02200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MQE22_02205	COG0140	phosphoribosyl-ATP diphosphatase activity
MQE22_02205	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MQE22_02210	COG0107	imidazoleglycerol-phosphate synthase activity
MQE22_02215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MQE22_02220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MQE22_02225	COG0131	Imidazoleglycerol-phosphate dehydratase
MQE22_02230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MQE22_02235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MQE22_02240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MQE22_02245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MQE22_02250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MQE22_02255	COG0271	Belongs to the BolA IbaG family
MQE22_02260	COG0842	Transport permease protein
MQE22_02265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MQE22_02270	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MQE22_02275	COG3178	'Phosphotransferase
MQE22_02280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MQE22_02300	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MQE22_02330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MQE22_02335	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MQE22_02340	COG1660	Displays ATPase and GTPase activities
MQE22_02350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MQE22_02360	COG0741	lytic transglycosylase activity
MQE22_02360	COG1388	LysM domain
MQE22_02365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MQE22_02370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MQE22_02375	COG0538	isocitrate dehydrogenase activity
MQE22_02380	COG0045	succinate-CoA ligase (ADP-forming) activity
MQE22_02390	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MQE22_02395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MQE22_02395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MQE22_02400	COG0347	Belongs to the P(II) protein family
MQE22_02410	COG0564	pseudouridine synthase activity
MQE22_02425	COG1850	ribulose-bisphosphate carboxylase activity
MQE22_02435	COG0235	Class ii aldolase
MQE22_02445	COG0242	peptide deformylase activity
MQE22_02495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MQE22_02520	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MQE22_02525	COG2154	pterin-4-alpha-carbinolamine dehydratase
MQE22_02545	COG0189	ligase activity
MQE22_02555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MQE22_02560	COG0751	glycine-tRNA ligase activity
MQE22_02610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MQE22_02615	COG0321	lipoyl(octanoyl) transferase activity
MQE22_02620	COG2921	Belongs to the UPF0250 family
MQE22_02625	COG1686	Belongs to the peptidase S11 family
MQE22_02630	COG0772	Belongs to the SEDS family
MQE22_02635	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MQE22_02645	COG1077	Cell shape determining protein MreB Mrl
MQE22_02650	COG0737	Belongs to the 5'-nucleotidase family
MQE22_02660	COG3258	Cytochrome c
MQE22_02680	COG2204	response regulator
MQE22_02685	COG5000	phosphorelay sensor kinase activity
MQE22_02695	COG0315	cyclic pyranopterin monophosphate synthase activity
MQE22_02705	COG0243	molybdopterin cofactor binding
MQE22_02710	COG0437	4 iron, 4 sulfur cluster binding
MQE22_02720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MQE22_02725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MQE22_02730	COG0425	Belongs to the sulfur carrier protein TusA family
MQE22_02735	COG2210	Belongs to the sulfur carrier protein TusA family
MQE22_02765	COG2048	Heterodisulfide reductase, subunit B
MQE22_02770	COG0509	glycine decarboxylation via glycine cleavage system
MQE22_02780	COG0509	glycine decarboxylation via glycine cleavage system
MQE22_02790	COG0095	Lipoate-protein ligase
MQE22_02795	COG0644	oxidoreductase
MQE22_02845	COG0123	including yeast histone deacetylase and acetoin utilization protein
MQE22_02860	COG0583	DNA-binding transcription factor activity
MQE22_02875	COG0586	Pfam SNARE associated Golgi protein
MQE22_02880	COG3152	Membrane
MQE22_02895	COG0791	NLP P60 protein
MQE22_02900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MQE22_02910	COG1199	ATP-dependent helicase activity
MQE22_02935	COG2801	Transposase and inactivated derivatives
MQE22_02940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MQE22_02945	COG0193	aminoacyl-tRNA hydrolase activity
MQE22_02950	COG0012	GTP binding
MQE22_02980	COG0494	nUDIX hydrolase
MQE22_02990	COG1187	pseudouridine synthase activity
MQE22_02995	COG2957	Belongs to the agmatine deiminase family
MQE22_03005	COG0210	DNA helicase
MQE22_03010	COG0268	Binds directly to 16S ribosomal RNA
MQE22_03015	COG0768	penicillin binding
MQE22_03035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MQE22_03040	COG1692	metallophosphoesterase
MQE22_03055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MQE22_03075	COG0442	prolyl-tRNA aminoacylation
MQE22_03100	COG1028	Short-chain dehydrogenase reductase Sdr
MQE22_03110	COG0142	geranyltranstransferase activity
MQE22_03140	COG0488	(ABC) transporter
MQE22_03150	COG1573	uracil-dna glycosylase
MQE22_03155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MQE22_03160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MQE22_03170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MQE22_03190	COG0848	biopolymer transport protein
MQE22_03195	COG0811	peptide transport
MQE22_03200	COG4772	TonB-dependent receptor
MQE22_03210	COG1561	YicC-like family, N-terminal region
MQE22_03225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MQE22_03240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MQE22_03245	COG2161	toxin-antitoxin pair type II binding
MQE22_03250	COG4115	mRNA cleavage
MQE22_03260	COG2199	diguanylate cyclase activity
MQE22_03270	COG0628	permease
MQE22_03280	COG0613	PHP domain protein
MQE22_03285	COG0628	permease
MQE22_03300	COG0084	hydrolase, TatD family'
MQE22_03305	COG0321	lipoyl(octanoyl) transferase activity
MQE22_03305	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MQE22_03330	COG0277	FAD linked oxidase domain protein
MQE22_03335	COG0277	FAD linked oxidase domain protein
MQE22_03340	COG0247	lactate metabolic process
MQE22_03345	COG1929	Belongs to the glycerate kinase type-1 family
MQE22_03360	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MQE22_03375	COG1294	oxidase, subunit
MQE22_03400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MQE22_03405	COG0156	8-amino-7-oxononanoate synthase activity
MQE22_03410	COG0438	transferase activity, transferring glycosyl groups
MQE22_03430	COG0662	Cupin 2, conserved barrel domain protein
MQE22_03430	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MQE22_03455	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MQE22_03490	COG0730	response to heat
MQE22_03510	COG2814	Major facilitator Superfamily
MQE22_03525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MQE22_03530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MQE22_03555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MQE22_03560	COG3258	Cytochrome c
MQE22_03570	COG1333	cytochrome c biogenesis protein
MQE22_03580	COG0737	Belongs to the 5'-nucleotidase family
MQE22_03600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MQE22_03605	COG0525	valine-tRNA ligase activity
MQE22_03620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MQE22_03655	COG1965	Belongs to the frataxin family
MQE22_03660	COG0514	ATP-dependent DNA helicase (RecQ)
MQE22_03670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MQE22_03680	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MQE22_03685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MQE22_03690	COG4191	Histidine kinase
MQE22_03695	COG2204	response regulator
MQE22_03705	COG1657	PFAM Prenyltransferase squalene oxidase
MQE22_03715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MQE22_03750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MQE22_03765	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MQE22_03770	COG0154	amidase activity
MQE22_03775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MQE22_03785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MQE22_03790	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
MQE22_03795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MQE22_03800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MQE22_03830	COG0590	tRNA wobble adenosine to inosine editing
MQE22_03835	COG0432	Pfam Uncharacterised protein family UPF0047
MQE22_03845	COG1193	negative regulation of DNA recombination
MQE22_03850	COG0028	Belongs to the TPP enzyme family
MQE22_03860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MQE22_03865	COG0688	phosphatidylethanolamine metabolic process
MQE22_03870	COG1183	phosphatidylcholine synthase activity
MQE22_03890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MQE22_03895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MQE22_03905	COG0450	alkyl hydroperoxide reductase
MQE22_03915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MQE22_03930	COG1850	ribulose-bisphosphate carboxylase activity
MQE22_03935	COG4451	ribulose bisphosphate carboxylase, small
MQE22_03960	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MQE22_03965	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MQE22_03970	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MQE22_04000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MQE22_04030	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MQE22_04050	COG1324	tolerance protein
MQE22_04055	COG4232	protein-disulfide reductase activity
MQE22_04070	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MQE22_04085	COG0167	dihydroorotate dehydrogenase activity
MQE22_04090	COG0408	coproporphyrinogen oxidase activity
MQE22_04095	COG0009	L-threonylcarbamoyladenylate synthase
MQE22_04100	COG0151	Belongs to the GarS family
MQE22_04105	COG0138	bifunctional purine biosynthesis protein purh
MQE22_04110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MQE22_04115	COG0529	Catalyzes the synthesis of activated sulfate
MQE22_04115	COG2046	Belongs to the sulfate adenylyltransferase family
MQE22_04125	COG1247	-acetyltransferase
MQE22_04130	COG0582	viral genome integration into host DNA
MQE22_04150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MQE22_04185	COG1193	negative regulation of DNA recombination
MQE22_04190	COG3619	membrane
MQE22_04195	COG0277	FAD linked oxidase domain protein
MQE22_04200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MQE22_04205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MQE22_04210	COG1428	Deoxynucleoside kinase
MQE22_04220	COG0617	tRNA 3'-terminal CCA addition
MQE22_04230	COG3180	Ammonia monooxygenase
MQE22_04240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MQE22_04240	COG0519	Catalyzes the synthesis of GMP from XMP
MQE22_04270	COG0697	spore germination
MQE22_04275	COG1902	pentaerythritol trinitrate reductase activity
MQE22_04280	COG0412	Dienelactone hydrolase
MQE22_04290	COG0084	hydrolase, TatD family'
MQE22_04295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MQE22_04310	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MQE22_04320	COG0640	Transcriptional regulator
MQE22_04345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MQE22_04350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MQE22_04360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MQE22_04385	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MQE22_04390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MQE22_04395	COG0196	riboflavin kinase activity
MQE22_04405	COG0741	lytic transglycosylase activity
MQE22_04415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MQE22_04420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MQE22_04425	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MQE22_04430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MQE22_04445	COG0840	transmembrane signaling receptor activity
MQE22_04445	COG5278	phosphoserine phosphatase activity
MQE22_04450	COG0784	Response regulator, receiver
MQE22_04450	COG0835	chemotaxis
MQE22_04480	COG0643	Histidine kinase
MQE22_04480	COG0784	Response regulator, receiver
MQE22_04480	COG2198	Histidine kinase
MQE22_04490	COG0745	RESPONSE REGULATOR receiver
MQE22_04510	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MQE22_04515	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MQE22_04535	COG1815	bacterial-type flagellum-dependent cell motility
MQE22_04540	COG1558	bacterial-type flagellum-dependent cell motility
MQE22_04545	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MQE22_04565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MQE22_04570	COG1706	bacterial-type flagellum-dependent cell motility
MQE22_04575	COG1705	Flagellar rod assembly protein muramidase FlgJ
MQE22_04575	COG3951	Flagellar rod assembly protein muramidase FlgJ
MQE22_04595	COG1216	Glycosyl transferase, family 2
MQE22_04595	COG0438	transferase activity, transferring glycosyl groups
MQE22_04635	COG3852	Histidine kinase
MQE22_04645	COG1677	Flagellar hook-basal body complex protein FliE
MQE22_04650	COG1766	The M ring may be actively involved in energy transduction
MQE22_04655	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MQE22_04700	COG1987	bacterial-type flagellum assembly
MQE22_04735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MQE22_04750	COG1487	ribonuclease activity
MQE22_04755	COG1064	alcohol dehydrogenase
MQE22_04760	COG0504	CTP synthase activity
MQE22_04765	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MQE22_04770	COG0148	phosphopyruvate hydratase activity
MQE22_04775	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MQE22_04780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MQE22_04790	COG0322	excinuclease ABC activity
MQE22_04800	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MQE22_04805	COG1074	ATP-dependent DNA helicase activity
MQE22_04810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MQE22_04850	COG2363	Small membrane protein
MQE22_04855	COG0616	signal peptide processing
MQE22_04860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MQE22_04865	COG0314	molybdopterin synthase activity
MQE22_04870	COG1666	GTP binding
MQE22_04880	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MQE22_04890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MQE22_04895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MQE22_04900	COG0714	Associated with various cellular activities
MQE22_04915	COG1132	(ABC) transporter
MQE22_04920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MQE22_04945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MQE22_04950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MQE22_04960	COG1193	negative regulation of DNA recombination
MQE22_04965	COG0358	DNA primase activity
MQE22_04990	COG4988	ABC transporter
MQE22_04995	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MQE22_05015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MQE22_05030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MQE22_05035	COG0481	GTPase activity
MQE22_05040	COG0681	Belongs to the peptidase S26 family
MQE22_05065	COG2022	thiamine diphosphate biosynthetic process
MQE22_05075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MQE22_05080	COG0163	prenyltransferase activity
MQE22_05085	COG1127	ABC transporter
MQE22_05090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MQE22_05105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MQE22_05120	COG0577	efflux transmembrane transporter activity
MQE22_05125	COG1136	(ABC) transporter
MQE22_05140	COG0459	protein refolding
MQE22_05145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MQE22_05170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MQE22_05180	COG1058	Belongs to the CinA family
MQE22_05180	COG1546	Belongs to the CinA family
MQE22_05185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MQE22_05190	COG2137	regulation of response to DNA damage stimulus
MQE22_05220	COG2814	Major facilitator Superfamily
MQE22_05230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MQE22_05245	COG0322	excinuclease ABC activity
MQE22_05265	COG0148	phosphopyruvate hydratase activity
MQE22_05270	COG0469	pyruvate kinase activity
MQE22_05280	COG1105	Belongs to the carbohydrate kinase PfkB family
MQE22_05285	COG0280	phosphate acetyltransferase
MQE22_05290	COG2814	Major facilitator Superfamily
MQE22_05295	COG1914	H( )-stimulated, divalent metal cation uptake system
MQE22_05300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MQE22_05305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MQE22_05325	COG0477	Major facilitator Superfamily
MQE22_05345	COG2353	YceI-like domain
MQE22_05350	COG0655	NAD(P)H dehydrogenase (quinone) activity
MQE22_05410	COG0745	RESPONSE REGULATOR receiver
MQE22_05415	COG2205	protein histidine kinase activity
MQE22_05425	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MQE22_05435	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MQE22_05445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MQE22_05475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MQE22_05500	COG0509	glycine decarboxylation via glycine cleavage system
MQE22_05520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MQE22_05520	COG1017	nitric oxide dioxygenase activity
MQE22_05550	COG4372	Transposase
MQE22_05565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MQE22_05570	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
MQE22_05570	COG3261	NADH dehydrogenase
MQE22_05575	COG0651	ATP synthesis coupled electron transport
MQE22_05585	COG0650	Formate hydrogenlyase subunit 4
MQE22_05590	COG0651	ATP synthesis coupled electron transport
MQE22_05610	COG1850	ribulose-bisphosphate carboxylase activity
MQE22_05620	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MQE22_05625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MQE22_05630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MQE22_05630	COG0574	Belongs to the PEP-utilizing enzyme family
MQE22_05640	COG0574	Belongs to the PEP-utilizing enzyme family
MQE22_05640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MQE22_05655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MQE22_05655	COG0574	Belongs to the PEP-utilizing enzyme family
MQE22_05670	COG2814	Major facilitator Superfamily
MQE22_05680	COG0531	amino acid
MQE22_05685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MQE22_05715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MQE22_05730	COG2801	Transposase and inactivated derivatives
MQE22_05735	COG1598	PFAM Uncharacterised protein family UPF0150
MQE22_05740	COG4372	Transposase
MQE22_05755	COG3344	reverse transcriptase
MQE22_05790	COG1845	cytochrome c oxidase, subunit III
MQE22_05795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MQE22_05800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MQE22_05810	COG0477	Major facilitator Superfamily
MQE22_05830	COG0811	peptide transport
MQE22_05835	COG0848	biopolymer transport protein
MQE22_05860	COG2188	Transcriptional regulator
MQE22_05865	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
MQE22_05875	COG3454	Phosphonate metabolism
MQE22_05880	COG4778	phosphonate C-P lyase system protein PhnL
MQE22_05885	COG4107	phosphonate C-P lyase system protein PhnK
MQE22_05890	COG3627	carbon phosphorus lyase activity
MQE22_05895	COG3626	phosphonate metabolism
MQE22_05915	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MQE22_05920	COG1196	nuclear chromosome segregation
MQE22_05930	COG2223	nitrite transmembrane transporter activity
MQE22_05935	COG1722	exodeoxyribonuclease VII activity
MQE22_05940	COG0142	geranyltranstransferase activity
MQE22_05945	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MQE22_05950	COG1469	GTP cyclohydrolase I activity
MQE22_05955	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MQE22_05960	COG2814	Major facilitator Superfamily
MQE22_05965	COG0542	response to heat
MQE22_05970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MQE22_05975	COG0308	aminopeptidase N
MQE22_05995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MQE22_06000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MQE22_06015	COG2719	SpoVR family
MQE22_06020	COG2718	Belongs to the UPF0229 family
MQE22_06025	COG2766	serine protein kinase
MQE22_06035	COG0842	Transport permease protein
MQE22_06040	COG0842	Transport permease protein
MQE22_06045	COG1131	(ABC) transporter
MQE22_06085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MQE22_06090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MQE22_06095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MQE22_06100	COG0004	ammonium transporteR
MQE22_06105	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MQE22_06105	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MQE22_06110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MQE22_06115	COG2239	Acts as a magnesium transporter
MQE22_06120	COG0802	atpase or kinase
MQE22_06125	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MQE22_06130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MQE22_06140	COG1289	transmembrane transporter activity
MQE22_06150	COG1566	PFAM secretion protein HlyD family protein
MQE22_06155	COG0571	ribonuclease III activity
MQE22_06165	COG1381	Involved in DNA repair and RecF pathway recombination
MQE22_06170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MQE22_06175	COG0736	holo-[acyl-carrier-protein] synthase activity
MQE22_06190	COG0037	tRNA processing
MQE22_06195	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MQE22_06205	COG1538	Outer membrane efflux protein
MQE22_06235	COG0076	glutamate decarboxylase activity
MQE22_06265	COG3220	belongs to the UPF0276 family
MQE22_06290	COG1335	isochorismatase
MQE22_06360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MQE22_06365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MQE22_06375	COG0436	Aminotransferase
MQE22_06385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MQE22_06395	COG1187	pseudouridine synthase activity
MQE22_06415	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MQE22_06445	COG0729	surface antigen
MQE22_06480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MQE22_06480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MQE22_06500	COG1132	(ABC) transporter
MQE22_06515	COG2860	membrane
MQE22_06520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MQE22_06535	COG0587	DNA-directed DNA polymerase activity
MQE22_06540	COG1113	amino acid transport
MQE22_06545	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MQE22_06545	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MQE22_06545	COG0506	proline dehydrogenase activity
MQE22_06550	COG0531	amino acid
MQE22_06555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MQE22_06560	COG3264	Mechanosensitive ion channel
MQE22_06560	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MQE22_06570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MQE22_06575	COG0009	L-threonylcarbamoyladenylate synthase
MQE22_06580	COG1994	Peptidase M50
MQE22_06585	COG0180	Tryptophanyl-tRNA synthetase
MQE22_06590	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MQE22_06595	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MQE22_06600	COG0446	pyridine nucleotide-disulphide oxidoreductase
MQE22_06615	COG2915	High frequency lysogenization protein hflD homolog
MQE22_06620	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MQE22_06625	COG0024	Methionine aminopeptidase
MQE22_06630	COG1489	DNA binding
MQE22_06635	COG0583	DNA-binding transcription factor activity
MQE22_06650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MQE22_06655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MQE22_06665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MQE22_06670	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MQE22_06675	COG1166	arginine decarboxylase activity
MQE22_06680	COG0179	Fumarylacetoacetate (FAA) hydrolase
MQE22_06690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MQE22_06710	COG4654	Cytochrome c, class I
MQE22_06730	COG0791	NLP P60 protein
MQE22_06735	COG2951	lytic endotransglycosylase activity
MQE22_06740	COG0402	S-adenosylhomocysteine deaminase activity
MQE22_06745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MQE22_06750	COG0546	phosphoglycolate phosphatase activity
MQE22_06765	COG2171	N-acyltransferase activity
MQE22_06770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MQE22_06785	COG0574	Belongs to the PEP-utilizing enzyme family
MQE22_06785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MQE22_06790	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MQE22_06800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MQE22_06815	COG0022	dehydrogenase e1 component
MQE22_06820	COG0508	dehydrogenase complex catalyzes the overall conversion of
MQE22_06825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MQE22_06845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MQE22_06850	COG1061	Type III restriction enzyme res subunit
MQE22_06860	COG1002	Type II restriction enzyme, methylase subunits
MQE22_06865	COG3093	addiction module antidote protein HigA
MQE22_06875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MQE22_06985	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
MQE22_07015	COG0582	viral genome integration into host DNA
MQE22_07025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MQE22_07045	COG3220	belongs to the UPF0276 family
MQE22_07080	COG0415	Belongs to the DNA photolyase family
MQE22_07105	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MQE22_07115	COG2026	Addiction module toxin, RelE StbE family
MQE22_07140	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MQE22_07150	COG0067	glutamate synthase
MQE22_07150	COG0069	glutamate synthase activity
MQE22_07150	COG0070	glutamate synthase
MQE22_07155	COG0493	'glutamate synthase
MQE22_07160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MQE22_07180	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MQE22_07195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MQE22_07200	COG1923	regulation of RNA biosynthetic process
MQE22_07205	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MQE22_07210	COG0424	maF-like protein
MQE22_07245	COG2062	phosphohistidine phosphatase, SixA
MQE22_07255	COG1160	GTP binding
MQE22_07260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MQE22_07270	COG0124	histidyl-tRNA synthetase
MQE22_07275	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MQE22_07290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MQE22_07295	COG0105	UTP biosynthetic process
MQE22_07305	COG0446	pyridine nucleotide-disulphide oxidoreductase
MQE22_07320	COG0037	tRNA processing
MQE22_07325	COG0825	malonyl-CoA metabolic process
MQE22_07335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MQE22_07340	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MQE22_07360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MQE22_07365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MQE22_07385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MQE22_07390	COG0575	Belongs to the CDS family
MQE22_07395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MQE22_07405	COG0528	UMP kinase activity
MQE22_07410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MQE22_07415	COG0052	Belongs to the universal ribosomal protein uS2 family
MQE22_07430	COG0704	Plays a role in the regulation of phosphate uptake
MQE22_07435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MQE22_07440	COG5002	protein histidine kinase activity
MQE22_07445	COG0745	RESPONSE REGULATOR receiver
MQE22_07450	COG0482	sulfurtransferase activity
MQE22_07465	COG0443	Heat shock 70 kDa protein
MQE22_07480	COG0822	iron-sulfur transferase activity
MQE22_07485	COG1104	cysteine desulfurase activity
MQE22_07490	COG1959	2 iron, 2 sulfur cluster binding
MQE22_07500	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MQE22_07515	COG2917	probably involved in intracellular septation
MQE22_07520	COG2350	Protein conserved in bacteria
MQE22_07525	COG0271	Belongs to the BolA IbaG family
MQE22_07530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MQE22_07530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MQE22_07540	COG0129	dihydroxy-acid dehydratase activity
MQE22_07545	COG0628	permease
MQE22_07550	COG0280	phosphate acetyltransferase
MQE22_07550	COG0281	malic enzyme
MQE22_07555	COG0254	rRNA binding
MQE22_07570	COG3511	phospholipase C
MQE22_07580	COG3706	GGDEF domain
MQE22_07610	COG2200	EAL domain
MQE22_07640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MQE22_07645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MQE22_07650	COG1862	Preprotein translocase
MQE22_07660	COG0343	queuine tRNA-ribosyltransferase activity
MQE22_07665	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MQE22_07670	COG1253	flavin adenine dinucleotide binding
MQE22_07685	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MQE22_07695	COG0285	dihydrofolate synthase activity
MQE22_07700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MQE22_07705	COG0159	tryptophan synthase activity
MQE22_07710	COG0133	tryptophan synthase activity
MQE22_07715	COG0135	phosphoribosylanthranilate isomerase activity
MQE22_07720	COG0101	tRNA pseudouridine synthase activity
MQE22_07730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MQE22_07750	COG1763	Mo-molybdopterin cofactor biosynthetic process
MQE22_07765	COG0415	Belongs to the DNA photolyase family
MQE22_07775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MQE22_07780	COG0670	Belongs to the BI1 family
MQE22_07785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MQE22_07825	COG3609	addiction module antidote protein, CC2985 family
MQE22_07845	COG1530	ribonuclease E activity
MQE22_07850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MQE22_07855	COG0215	cysteine-tRNA ligase activity
MQE22_07860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MQE22_07875	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MQE22_07880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MQE22_07890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MQE22_07905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MQE22_07910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MQE22_07920	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MQE22_07920	COG2755	lipolytic protein G-D-S-L family
MQE22_07925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MQE22_07925	COG2755	lipolytic protein G-D-S-L family
MQE22_07935	COG2132	Multicopper oxidase
MQE22_07970	COG1686	Belongs to the peptidase S11 family
MQE22_07990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MQE22_08040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MQE22_08050	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MQE22_08070	COG1215	transferase activity, transferring glycosyl groups
MQE22_08075	COG0463	Glycosyl transferase, family 2
MQE22_08080	COG2244	polysaccharide biosynthetic process
MQE22_08085	COG4636	protein conserved in cyanobacteria
MQE22_08095	COG3041	Addiction module toxin RelE StbE family
MQE22_08100	COG3077	Addiction module antitoxin, RelB DinJ family
MQE22_08130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MQE22_08145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MQE22_08150	COG1570	exodeoxyribonuclease VII activity
MQE22_08170	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MQE22_08195	COG2326	polyphosphate kinase activity
MQE22_08200	COG0557	exoribonuclease II activity
MQE22_08215	COG3247	response to pH
MQE22_08220	COG2257	FlhB HrpN YscU SpaS Family
MQE22_08235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MQE22_08255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MQE22_08260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MQE22_08265	COG0740	serine-type endopeptidase activity
MQE22_08270	COG0544	peptidyl-prolyl cis-trans isomerase activity
MQE22_08275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MQE22_08280	COG0284	orotidine-5'-phosphate decarboxylase activity
MQE22_08285	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MQE22_08290	COG0776	regulation of translation
MQE22_08300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MQE22_08305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MQE22_08310	COG0287	Prephenate dehydrogenase
MQE22_08315	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MQE22_08325	COG1605	Chorismate mutase
MQE22_08325	COG0077	Prephenate dehydratase
MQE22_08330	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MQE22_08340	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MQE22_08345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MQE22_08355	COG1475	DNA binding
MQE22_08360	COG1192	Involved in chromosome partitioning
MQE22_08375	COG2948	multi-organism process
MQE22_08420	COG3451	type IV secretory pathway VirB4
MQE22_08440	COG4962	Type ii secretion system protein e
MQE22_08450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MQE22_08460	COG1937	Protein conserved in bacteria
MQE22_08470	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MQE22_08510	COG1285	pathogenesis
MQE22_08525	COG3384	dioxygenase
MQE22_08530	COG2353	YceI-like domain
MQE22_08535	COG0655	NAD(P)H dehydrogenase (quinone) activity
MQE22_08540	COG1733	regulation of RNA biosynthetic process
MQE22_08600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MQE22_08605	COG2801	Transposase and inactivated derivatives
MQE22_08670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MQE22_08680	COG0629	single-stranded DNA binding
MQE22_08850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MQE22_08955	COG0741	lytic transglycosylase activity
MQE22_08955	COG1196	nuclear chromosome segregation
MQE22_08955	COG0739	heme binding
MQE22_08980	COG0586	Pfam SNARE associated Golgi protein
MQE22_09020	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MQE22_09025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MQE22_09030	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MQE22_09050	COG1271	oxidase subunit
MQE22_09055	COG1294	oxidase, subunit
MQE22_09085	COG0655	NAD(P)H dehydrogenase (quinone) activity
MQE22_09095	COG0500	methyltransferase
MQE22_09110	COG2205	protein histidine kinase activity
MQE22_09110	COG0784	Response regulator, receiver
MQE22_09120	COG3706	GGDEF domain
MQE22_09170	COG0642	Histidine kinase
MQE22_09200	COG0463	Glycosyl transferase, family 2
MQE22_09215	COG1902	pentaerythritol trinitrate reductase activity
MQE22_09245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MQE22_09320	COG0470	DNA polymerase III
MQE22_09325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MQE22_09330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MQE22_09340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MQE22_09345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MQE22_09350	COG1028	Short-chain dehydrogenase reductase Sdr
MQE22_09355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MQE22_09360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MQE22_09365	COG0416	fatty acid biosynthetic process
MQE22_09370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MQE22_09380	COG0505	Belongs to the CarA family
MQE22_09390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MQE22_09395	COG1968	undecaprenyl-diphosphatase activity
MQE22_09400	COG2814	Major facilitator Superfamily
MQE22_09405	COG0109	protoheme IX farnesyltransferase activity
MQE22_09420	COG1845	cytochrome c oxidase, subunit III
MQE22_09425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MQE22_09440	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MQE22_09445	COG0259	pyridoxamine-phosphate oxidase activity
MQE22_09455	COG0066	3-isopropylmalate dehydratase activity
MQE22_09465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MQE22_09470	COG0312	modulator of DNA gyrase
MQE22_09480	COG0347	Belongs to the P(II) protein family
MQE22_09485	COG0505	Belongs to the CarA family
MQE22_09490	COG0004	ammonium transporteR
MQE22_09515	COG3852	Histidine kinase
MQE22_09550	COG2308	Evidence 4 Homologs of previously reported genes of
MQE22_09565	COG0004	ammonium transporteR
MQE22_09570	COG0326	Molecular chaperone. Has ATPase activity
MQE22_09580	COG2201	protein-glutamate methylesterase activity
MQE22_09585	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MQE22_09595	COG0835	chemotaxis
MQE22_09600	COG0840	transmembrane signaling receptor activity
MQE22_09605	COG0643	Histidine kinase
MQE22_09605	COG2198	Histidine kinase
MQE22_09615	COG0745	RESPONSE REGULATOR receiver
MQE22_09625	COG1271	oxidase subunit
MQE22_09645	COG4372	Transposase
MQE22_09680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MQE22_09685	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
MQE22_09700	COG3547	Transposase (IS116 IS110 IS902 family)
MQE22_09730	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MQE22_09735	COG1534	Rna-binding protein
MQE22_09740	COG0495	leucyl-tRNA aminoacylation
MQE22_09750	COG1466	dna polymerase III delta subunit
MQE22_09755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MQE22_09765	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MQE22_09775	COG0006	proline dipeptidase activity
MQE22_09790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MQE22_09790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MQE22_09805	COG0450	alkyl hydroperoxide reductase
MQE22_09810	COG1605	Chorismate mutase
MQE22_09810	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MQE22_09815	COG0114	fumarate hydratase activity
MQE22_09845	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MQE22_09850	COG1194	a g-specific adenine glycosylase
MQE22_09860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MQE22_09875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MQE22_09880	COG0497	DNA recombination
MQE22_09900	COG2204	response regulator
MQE22_09910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MQE22_09930	COG0297	glycogen (starch) synthase activity
MQE22_09935	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MQE22_09945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MQE22_09955	COG1388	LysM domain
MQE22_09955	COG1376	ErfK ybiS ycfS ynhG family protein
MQE22_09975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MQE22_09995	COG0577	efflux transmembrane transporter activity
MQE22_09995	COG1136	(ABC) transporter
MQE22_10005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MQE22_10010	COG1309	transcriptional regulator
MQE22_10020	COG1017	nitric oxide dioxygenase activity
MQE22_10020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MQE22_10040	COG3189	MarR family transcriptional regulator
MQE22_10045	COG1566	PFAM secretion protein HlyD family protein
MQE22_10050	COG1538	Outer membrane efflux protein
MQE22_10055	COG0477	Major facilitator Superfamily
MQE22_10060	COG3707	response regulator
MQE22_10070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MQE22_10070	COG1648	precorrin-2 dehydrogenase activity
MQE22_10075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MQE22_10080	COG0243	molybdopterin cofactor binding
MQE22_10085	COG2146	nitrite reductase [NAD(P)H] activity
MQE22_10090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MQE22_10100	COG2223	nitrite transmembrane transporter activity
MQE22_10105	COG1116	anion transmembrane transporter activity
MQE22_10105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MQE22_10110	COG1573	uracil-dna glycosylase
MQE22_10115	COG0583	DNA-binding transcription factor activity
MQE22_10120	COG0527	aspartate kinase activity
MQE22_10125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MQE22_10130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MQE22_10135	COG0137	argininosuccinate synthase activity
MQE22_10150	COG0328	RNA-DNA hybrid ribonuclease activity
MQE22_10160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MQE22_10165	COG0612	Peptidase, M16
MQE22_10170	COG1185	polyribonucleotide nucleotidyltransferase activity
MQE22_10175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MQE22_10180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MQE22_10185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MQE22_10190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MQE22_10195	COG0195	Participates in both transcription termination and antitermination
MQE22_10195	COG2251	uridine kinase activity
MQE22_10200	COG0779	Required for maturation of 30S ribosomal subunits
MQE22_10235	COG1376	ErfK ybiS ycfS ynhG family protein
MQE22_10235	COG1388	LysM domain
MQE22_10245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MQE22_10250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MQE22_10260	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MQE22_10270	COG0492	ferredoxin-NADP+ reductase activity
MQE22_10285	COG0585	pseudouridine synthase activity
MQE22_10290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MQE22_10295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MQE22_10300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MQE22_10305	COG0560	Phosphoserine phosphatase
MQE22_10310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MQE22_10310	COG0678	peroxiredoxin activity
MQE22_10315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MQE22_10325	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MQE22_10345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MQE22_10350	COG2003	Belongs to the UPF0758 family
MQE22_10360	COG0756	dUTP diphosphatase activity
MQE22_10370	COG0717	Belongs to the dCTP deaminase family
MQE22_10375	COG0489	protein tyrosine kinase activity
MQE22_10385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MQE22_10390	COG0484	heat shock protein binding
MQE22_10395	COG0443	Heat shock 70 kDa protein
MQE22_10400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MQE22_10405	COG1420	regulation of RNA biosynthetic process
MQE22_10410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MQE22_10415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MQE22_10420	COG0531	amino acid
MQE22_10450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MQE22_10465	COG1773	rubredoxin
MQE22_10485	COG1953	Uracil, thiamine, allantoin
MQE22_10500	COG0493	'glutamate synthase
MQE22_10500	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MQE22_10510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MQE22_10520	COG0583	DNA-binding transcription factor activity
MQE22_10560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MQE22_10585	COG0811	peptide transport
MQE22_10610	COG3046	protein related to deoxyribodipyrimidine photolyase
MQE22_10630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MQE22_10640	COG2211	Major facilitator Superfamily
MQE22_10650	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MQE22_10675	COG1671	Belongs to the UPF0178 family
MQE22_10685	COG1028	Short-chain dehydrogenase reductase Sdr
MQE22_10765	COG1178	ABC-type Fe3 transport system permease component
MQE22_10775	COG3842	ATPase activity
MQE22_10795	COG2885	chlorophyll binding
MQE22_10815	COG0776	regulation of translation
MQE22_10820	COG0072	phenylalanine-tRNA ligase activity
MQE22_10820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MQE22_10825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MQE22_10830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MQE22_10835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MQE22_10840	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MQE22_10845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MQE22_10860	COG1007	ATP synthesis coupled electron transport
MQE22_10875	COG0713	ATP synthesis coupled electron transport
MQE22_10880	COG0839	Belongs to the complex I subunit 6 family
MQE22_10885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MQE22_10890	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MQE22_10895	COG1034	ATP synthesis coupled electron transport
MQE22_10910	COG0649	NAD binding
MQE22_10915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MQE22_10920	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MQE22_10925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MQE22_10935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MQE22_10940	COG0149	triose-phosphate isomerase activity
MQE22_10945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MQE22_10950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MQE22_10955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MQE22_10960	COG0312	modulator of DNA gyrase
MQE22_10965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MQE22_10965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MQE22_10970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MQE22_10980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MQE22_10985	COG2813	Specifically methylates the guanine in position
MQE22_10985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MQE22_10995	COG2226	methyltransferase
MQE22_11000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MQE22_11005	COG0659	secondary active sulfate transmembrane transporter activity
MQE22_11040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MQE22_11045	COG0768	penicillin binding
MQE22_11050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MQE22_11065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MQE22_11070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MQE22_11075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MQE22_11080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MQE22_11090	COG0501	Belongs to the peptidase M48B family
MQE22_11110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MQE22_11115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MQE22_11130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MQE22_11135	COG3001	Fructosamine kinase
MQE22_11140	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MQE22_11145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MQE22_11150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MQE22_11155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MQE22_11190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MQE22_11195	COG0762	integral membrane protein
MQE22_11200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MQE22_11210	COG1566	PFAM secretion protein HlyD family protein
MQE22_11245	COG0543	2 iron, 2 sulfur cluster binding
MQE22_11245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MQE22_11255	COG0390	transport system, permease component
MQE22_11270	COG2801	Transposase and inactivated derivatives
MQE22_11275	COG1192	Involved in chromosome partitioning
MQE22_11295	COG3436	PFAM IS66 Orf2 family protein
MQE22_11325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MQE22_11330	COG2226	methyltransferase
MQE22_11335	COG2267	carboxylic ester hydrolase activity
MQE22_11340	COG0156	8-amino-7-oxononanoate synthase activity
MQE22_11345	COG1040	competence protein
MQE22_11350	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MQE22_11355	COG0477	Major facilitator Superfamily
MQE22_11360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MQE22_11365	COG1519	Transferase
MQE22_11375	COG0859	PFAM glycosyl transferase family 9
MQE22_11380	COG0463	Glycosyl transferase, family 2
MQE22_11400	COG0438	transferase activity, transferring glycosyl groups
MQE22_11410	COG0463	Glycosyl transferase, family 2
MQE22_11415	COG0494	nUDIX hydrolase
MQE22_11420	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MQE22_11425	COG0653	protein targeting
MQE22_11435	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MQE22_11440	COG0625	glutathione transferase activity
MQE22_11460	COG2001	Belongs to the MraZ family
MQE22_11465	COG0275	rRNA processing
MQE22_11480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MQE22_11485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MQE22_11490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MQE22_11495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MQE22_11500	COG0772	Belongs to the SEDS family
MQE22_11505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MQE22_11510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MQE22_11515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MQE22_11520	COG1181	Belongs to the D-alanine--D-alanine ligase family
MQE22_11555	COG0583	DNA-binding transcription factor activity
MQE22_11560	COG3002	Belongs to the UPF0753 family
MQE22_11565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MQE22_11580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MQE22_11590	COG0649	NAD binding
MQE22_11590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MQE22_11595	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MQE22_11605	COG1034	ATP synthesis coupled electron transport
MQE22_11610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MQE22_11615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MQE22_11625	COG0713	ATP synthesis coupled electron transport
MQE22_11630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MQE22_11635	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MQE22_11640	COG1007	ATP synthesis coupled electron transport
MQE22_11650	COG0650	Formate hydrogenlyase subunit 4
MQE22_11660	COG0651	ATP synthesis coupled electron transport
MQE22_11665	COG3261	NADH dehydrogenase
MQE22_11665	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
MQE22_11670	COG3260	NADH ubiquinone oxidoreductase 20
MQE22_11675	COG0651	ATP synthesis coupled electron transport
MQE22_11680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MQE22_11695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MQE22_11700	COG0406	alpha-ribazole phosphatase activity
MQE22_11805	COG4964	Belongs to the GSP D family
MQE22_11850	COG2885	chlorophyll binding
MQE22_11860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MQE22_11875	COG2833	Protein of unknown function (DUF455)
MQE22_11905	COG0386	Belongs to the glutathione peroxidase family
MQE22_11935	COG2095	MarC family integral membrane protein
MQE22_11945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MQE22_11955	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MQE22_11965	COG0217	transcriptional regulatory protein
MQE22_11970	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MQE22_11975	COG0632	four-way junction helicase activity
MQE22_11980	COG2255	four-way junction helicase activity
MQE22_11985	COG0824	Thioesterase
MQE22_12005	COG0823	Involved in the tonB-independent uptake of proteins
MQE22_12010	COG1280	lysine exporter protein (LysE YggA)
MQE22_12015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MQE22_12020	COG0602	queuosine metabolic process
MQE22_12030	COG2885	chlorophyll binding
MQE22_12035	COG0181	hydroxymethylbilane synthase activity
MQE22_12045	COG0113	porphobilinogen synthase activity
MQE22_12055	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MQE22_12075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MQE22_12100	COG2204	response regulator
MQE22_12110	COG2205	protein histidine kinase activity
MQE22_12115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MQE22_12120	COG0540	Belongs to the ATCase OTCase family
MQE22_12125	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MQE22_12130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MQE22_12135	COG1678	Uncharacterized ACR, COG1678
MQE22_12140	COG0189	ligase activity
MQE22_12155	COG0316	Belongs to the HesB IscA family
MQE22_12165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MQE22_12170	COG0022	dehydrogenase e1 component
MQE22_12170	COG0508	dehydrogenase complex catalyzes the overall conversion of
MQE22_12175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MQE22_12190	COG3300	MHYT domain
MQE22_12190	COG5001	Diguanylate cyclase
MQE22_12200	COG2200	EAL domain
MQE22_12205	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MQE22_12210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MQE22_12215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MQE22_12225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MQE22_12230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MQE22_12235	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MQE22_12240	COG1127	ABC transporter
MQE22_12245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MQE22_12250	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MQE22_12265	COG1131	(ABC) transporter
MQE22_12270	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MQE22_12275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MQE22_12285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MQE22_12300	COG0018	arginyl-trna synthetase
MQE22_12305	COG3264	Mechanosensitive ion channel
MQE22_12305	COG1511	domain protein
MQE22_12315	COG0583	DNA-binding transcription factor activity
MQE22_12325	COG0708	Exodeoxyribonuclease III
MQE22_12340	COG0625	glutathione transferase activity
MQE22_12350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MQE22_12355	COG1047	Peptidyl-prolyl cis-trans
MQE22_12360	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MQE22_12365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MQE22_12370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MQE22_12390	COG0237	dephospho-CoA kinase activity
MQE22_12400	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MQE22_12435	COG0741	lytic transglycosylase activity
MQE22_12440	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MQE22_12455	COG0439	Biotin carboxylase
MQE22_12460	COG0511	ligase activity, forming carbon-carbon bonds
MQE22_12465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MQE22_12470	COG0778	Nitroreductase
MQE22_12475	COG0488	(ABC) transporter
MQE22_12480	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MQE22_12490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MQE22_12495	COG1333	cytochrome c biogenesis protein
MQE22_12515	COG1611	Belongs to the LOG family
MQE22_12525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MQE22_12540	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MQE22_12545	COG3657	addiction module killer protein
MQE22_12570	COG2161	toxin-antitoxin pair type II binding
MQE22_12575	COG3344	reverse transcriptase
MQE22_12615	COG0165	Argininosuccinate lyase
MQE22_12635	COG0418	dihydroorotase activity
MQE22_12645	COG2885	chlorophyll binding
MQE22_12675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MQE22_12695	COG1393	Belongs to the ArsC family
MQE22_12705	COG0583	DNA-binding transcription factor activity
MQE22_12725	COG2885	chlorophyll binding
MQE22_12745	COG0277	FAD linked oxidase domain protein
MQE22_12750	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MQE22_12755	COG0792	nuclease activity
MQE22_12780	COG1196	nuclear chromosome segregation
MQE22_12795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MQE22_12815	COG4691	Plasmid stability protein
MQE22_12820	COG1487	ribonuclease activity
MQE22_12865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MQE22_12885	COG0776	regulation of translation
MQE22_12920	COG0431	NADPH-dependent FMN reductase
MQE22_12935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MQE22_12945	COG1595	DNA-templated transcription, initiation
MQE22_12965	COG1538	Outer membrane efflux protein
MQE22_12975	COG1131	(ABC) transporter
MQE22_12980	COG1131	(ABC) transporter
MQE22_12985	COG0842	Transport permease protein
MQE22_12990	COG0842	Transport permease protein
MQE22_13005	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MQE22_13020	COG3220	belongs to the UPF0276 family
MQE22_13040	COG4232	protein-disulfide reductase activity
MQE22_13060	COG2814	Major facilitator Superfamily
MQE22_13070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MQE22_13070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MQE22_13085	COG2226	methyltransferase
MQE22_13115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MQE22_13145	COG0629	single-stranded DNA binding
MQE22_13150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MQE22_13150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MQE22_13165	COG3561	AntA/AntB antirepressor
MQE22_13190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MQE22_13235	COG4962	Type ii secretion system protein e
MQE22_13310	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MQE22_13375	COG2217	Heavy metal translocating P-type atpase
MQE22_13405	COG3451	type IV secretory pathway VirB4
MQE22_13435	COG4680	protein conserved in bacteria
MQE22_13475	COG3504	Conjugal transfer protein
MQE22_13490	COG0489	protein tyrosine kinase activity
MQE22_13495	COG1475	DNA binding
MQE22_13500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MQE22_13505	COG0433	COG0433 Predicted ATPase
MQE22_13520	COG0488	(ABC) transporter
MQE22_13530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MQE22_13535	COG0594	ribonuclease P activity
MQE22_13540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MQE22_13545	COG0706	membrane insertase activity
MQE22_13550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MQE22_13570	COG1560	Kdo2-lipid A biosynthetic process
MQE22_13575	COG0668	transmembrane transport
MQE22_13595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MQE22_13605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MQE22_13620	COG0424	maF-like protein
MQE22_13625	COG1530	ribonuclease E activity
MQE22_13630	COG1555	photosystem II stabilization
MQE22_13640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MQE22_13645	COG0352	thiamine-phosphate diphosphorylase activity
MQE22_13650	COG0351	phosphomethylpyrimidine kinase
MQE22_13660	COG0300	oxidoreductase activity
MQE22_13695	COG3668	Plasmid stabilization system
MQE22_13700	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MQE22_13720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MQE22_13735	COG1216	Glycosyl transferase, family 2
MQE22_13735	COG0438	transferase activity, transferring glycosyl groups