locus-tag	class	description
GCD22_00001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
GCD22_00002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
GCD22_00003	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
GCD22_00004	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
GCD22_00008	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
GCD22_00009	ENOG4107QMS	site-determining protein
GCD22_00010	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
GCD22_00011	ENOG4108Z4U	Ferredoxin
GCD22_00013	ENOG4108RPN	Protein smg homolog
GCD22_00014	ENOG4105C79	DNA protecting protein DprA
GCD22_00016	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
GCD22_00017	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
GCD22_00018	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
GCD22_00020	ENOG4105ES5	Histidine kinase
GCD22_00021	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GCD22_00024	ENOG4105CQB	FAD linked oxidase domain protein
GCD22_00025	ENOG4105EU8	FAD linked oxidase domain protein
GCD22_00026	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
GCD22_00031	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
GCD22_00035	ENOG4105DFS	Conserved Protein
GCD22_00041	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
GCD22_00042	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
GCD22_00043	ENOG4107QJE	Chromosome Partitioning Protein
GCD22_00046	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
GCD22_00047	ENOG41082T0	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
GCD22_00048	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
GCD22_00049	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
GCD22_00050	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
GCD22_00051	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
GCD22_00052	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
GCD22_00053	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
GCD22_00054	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
GCD22_00055	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
GCD22_00057	ENOG4105D29	Helix-turn-helix type 11 domain protein
GCD22_00063	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
GCD22_00073	ENOG4108VSE	mercuric transport protein
GCD22_00076	ENOG4107TPS	domain protein
GCD22_00078	ENOG4105C57	major facilitator superfamily
GCD22_00082	ENOG4105E18	UPF0276 protein
GCD22_00086	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
GCD22_00103	ENOG4108IJF	Heavy metal efflux pump, CzcA
GCD22_00105	ENOG4105BZU	Histidine kinase
GCD22_00108	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
GCD22_00111	ENOG4105C4R	Atp-dependent dna helicase
GCD22_00113	ENOG4105CUV	Homoserine Kinase
GCD22_00115	ENOG4108URH	decarboxylase
GCD22_00116	ENOG4105C2M	dna polymerase I
GCD22_00117	ENOG4107SVH	Potassium channel protein
GCD22_00118	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
GCD22_00120	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
GCD22_00121	ENOG4105CRE	cytochrome C
GCD22_00123	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
GCD22_00126	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
GCD22_00132	ENOG4105CBX	hi0933 family
GCD22_00136	ENOG4105C2C	drug resistance transporter, Bcr CflA
GCD22_00138	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GCD22_00139	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GCD22_00140	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GCD22_00141	ENOG4105GKE	subunit e
GCD22_00142	ENOG4107QIZ	NADH dehydrogenase
GCD22_00143	ENOG4108IEH	NADH dehydrogenase subunit g
GCD22_00143	ENOG4108IEH	NADH dehydrogenase subunit g
GCD22_00144	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
GCD22_00146	ENOG4107UFS	subunit j
GCD22_00149	ENOG4105D65	subunit l
GCD22_00150	ENOG4105C8S	subunit m
GCD22_00151	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GCD22_00152	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
GCD22_00153	ENOG4108UJD	30S ribosomal protein S9
GCD22_00154	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
GCD22_00155	ENOG4105BZU	Histidine kinase
GCD22_00163	ENOG4105RWF	major outer membrane protein OmpA
GCD22_00164	ENOG4107R0V	Pyruvate dehydrogenase
GCD22_00168	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
GCD22_00169	ENOG4105BZN	citrate synthase
GCD22_00171	ENOG4105D7Z	glutathione synthase
GCD22_00174	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
GCD22_00175	ENOG4105CXT	aspartate transcarbamylase
GCD22_00176	ENOG4105CD3	dihydroorotase
GCD22_00182	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
GCD22_00183	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
GCD22_00184	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
GCD22_00185	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
GCD22_00186	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
GCD22_00187	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
GCD22_00188	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
GCD22_00189	ENOG4105CIH	Imidazole acetol-phosphate transaminase
GCD22_00190	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
GCD22_00191	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
GCD22_00192	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
GCD22_00195	ENOG4105E3A	(ABC) transporter
GCD22_00196	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
GCD22_00197	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
GCD22_00198	ENOG4105EHM	Aminoglycoside phosphotransferase
GCD22_00199	ENOG4108S0S	Nucleotidyl transferase
GCD22_00202	ENOG4105C2X	Arabinose 5-phosphate isomerase
GCD22_00203	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
GCD22_00205	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
GCD22_00206	ENOG4108IUZ	ABC transporter
GCD22_00207	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GCD22_00208	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
GCD22_00209	ENOG4105DM4	PTS System
GCD22_00210	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
GCD22_00214	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
GCD22_00216	ENOG4105CEN	a g-specific adenine glycosylase
GCD22_00222	ENOG4107WP9	Histidine kinase
GCD22_00224	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GCD22_00225	ENOG4105CVK	Glutamate decarboxylase
GCD22_00226	ENOG41082J7	Rhodanese domain protein
GCD22_00227	ENOG410902C	phosphohistidine phosphatase, SixA
GCD22_00228	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
GCD22_00229	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
GCD22_00230	ENOG4105DHJ	ABC, transporter
GCD22_00231	ENOG4105CY3	ABC transporter, permease
GCD22_00232	ENOG4107PE3	Mammalian cell entry related domain protein
GCD22_00235	ENOG4105DA5	(ABC) transporter
GCD22_00237	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
GCD22_00239	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
GCD22_00242	ENOG4105C75	arginyL-tRNA synthetase
GCD22_00243	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GCD22_00244	ENOG4105DND	Transcriptional regulator
GCD22_00245	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
GCD22_00246	ENOG4105CGK	Exodeoxyribonuclease III
GCD22_00248	ENOG4105D6S	protein involved in catabolism of external DNA
GCD22_00249	ENOG4108U78	Glutathione S-transferase
GCD22_00250	ENOG4105CGK	Exodeoxyribonuclease III
GCD22_00251	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
GCD22_00252	ENOG4108YZY	peptidylprolyl cis-trans isomerase
GCD22_00253	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
GCD22_00254	ENOG4105E2X	shikimate dehydrogenase
GCD22_00255	ENOG4107QHF	type ii secretion system protein e
GCD22_00256	ENOG4107TUY	Histidine kinase
GCD22_00257	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GCD22_00258	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
GCD22_00260	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
GCD22_00261	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GCD22_00272	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
GCD22_00283	ENOG4105E4C	Lytic transglycosylase catalytic
GCD22_00286	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
GCD22_00287	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
GCD22_00288	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
GCD22_00289	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
GCD22_00292	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
GCD22_00293	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
GCD22_00294	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
GCD22_00295	ENOG4105CPF	Cell wall formation (By similarity)
GCD22_00296	ENOG4105D4A	Cell wall formation (By similarity)
GCD22_00297	ENOG4105DFU	Cell wall formation (By similarity)
GCD22_00298	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
GCD22_00299	ENOG4105CNI	cell division protein FtsW
GCD22_00300	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
GCD22_00301	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
GCD22_00302	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
GCD22_00303	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
GCD22_00304	ENOG4105CJN	penicillin-binding protein
GCD22_00306	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
GCD22_00307	ENOG4108V6E	Cell division protein mraZ
GCD22_00311	ENOG4107MKT	Stringent starvation protein a
GCD22_00312	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
GCD22_00313	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
GCD22_00314	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
GCD22_00315	ENOG4105M6F	mutator MutT protein
GCD22_00316	ENOG4105CKK	Glycosyl transferase, family 2
GCD22_00318	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
GCD22_00322	ENOG4106WTF	Glycosyl transferase, family 2
GCD22_00323	ENOG4105D16	lipopolysaccharide heptosyltransferase i
GCD22_00325	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
GCD22_00326	ENOG4105C87	Aminotransferase class I and II
GCD22_00328	ENOG4108KK1	membrane protein AbrB duplication
GCD22_00329	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
GCD22_00330	ENOG4105MJ2	Competence protein
GCD22_00331	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
GCD22_00332	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
GCD22_00333	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
GCD22_00334	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
GCD22_00335	ENOG4105D0M	Protease HtpX homolog
GCD22_00336	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
GCD22_00337	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
GCD22_00338	ENOG4105C4B	ABC transporter, permease
GCD22_00339	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
GCD22_00344	ENOG4105R8C	Transcriptional regulator
GCD22_00345	ENOG4105CAS	nag kinase
GCD22_00347	ENOG4105CW7	secretion protein, HlyD family
GCD22_00349	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
GCD22_00351	ENOG4105II7	pyrroline-5-carboxylate reductase
GCD22_00353	ENOG4105CZX	twitching motility protein
GCD22_00354	ENOG4105CZX	twitching motility protein
GCD22_00358	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
GCD22_00359	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
GCD22_00360	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
GCD22_00361	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
GCD22_00363	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
GCD22_00365	ENOG4108Z1B	Cyclase dehydrase
GCD22_00367	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
GCD22_00368	ENOG41090R7	Ferric uptake
GCD22_00369	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
GCD22_00370	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GCD22_00371	ENOG4105K46	50S ribosomal protein l27
GCD22_00372	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
GCD22_00374	ENOG4105C26	Dehydrogenase
GCD22_00375	ENOG4105CHH	sulfate transporter
GCD22_00376	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
GCD22_00377	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
GCD22_00379	ENOG4105DWV	Homoserine O-trans-acetylase
GCD22_00380	ENOG4105DWV	Homoserine O-trans-acetylase
GCD22_00382	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
GCD22_00383	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
GCD22_00384	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
GCD22_00386	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
GCD22_00387	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
GCD22_00388	ENOG4107YIM	Involved in the transcription termination process (By similarity)
GCD22_00391	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
GCD22_00396	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
GCD22_00399	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
GCD22_00400	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
GCD22_00401	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
GCD22_00402	ENOG4108VZM	50s ribosomal protein L10
GCD22_00403	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
GCD22_00404	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GCD22_00405	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GCD22_00406	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
GCD22_00407	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
GCD22_00408	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
GCD22_00409	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
GCD22_00410	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
GCD22_00411	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
GCD22_00412	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
GCD22_00413	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
GCD22_00414	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GCD22_00415	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
GCD22_00416	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
GCD22_00418	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
GCD22_00420	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
GCD22_00421	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
GCD22_00422	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
GCD22_00423	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GCD22_00424	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
GCD22_00425	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
GCD22_00426	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
GCD22_00427	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
GCD22_00428	ENOG41084RK	50S ribosomal protein L30
GCD22_00429	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
GCD22_00430	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
GCD22_00431	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
GCD22_00432	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
GCD22_00433	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GCD22_00434	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
GCD22_00435	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
GCD22_00436	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GCD22_00437	ENOG4108ZT0	50S ribosomal protein l17
GCD22_00439	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
GCD22_00440	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
GCD22_00441	ENOG4105W5Q	DNA repair protein (RadC
GCD22_00447	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
GCD22_00450	ENOG4105EHV	domain protein
GCD22_00452	ENOG4108JA2	transcriptioN-repair coupling factor
GCD22_00454	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
GCD22_00455	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
GCD22_00456	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
GCD22_00458	ENOG410681U	heavy metal transport detoxification protein
GCD22_00460	ENOG4105C3M	thioredoxin reductase
GCD22_00461	ENOG4105CAU	Arsenical resistance protein, ArsH
GCD22_00463	ENOG4105CNU	cell division protein FtsK
GCD22_00464	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
GCD22_00466	ENOG4105D1H	recombination factor protein RarA
GCD22_00467	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
GCD22_00469	ENOG4108PXI	ErfK YbiS YcfS YnhG
GCD22_00476	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
GCD22_00477	ENOG4105CHV	Transcription elongation factor NusA
GCD22_00478	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
GCD22_00479	ENOG41082KD	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
GCD22_00480	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
GCD22_00481	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
GCD22_00482	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
GCD22_00484	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
GCD22_00485	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
GCD22_00486	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
GCD22_00487	ENOG4108JDX	DNA polymerase iii, epsilon subunit
GCD22_00489	ENOG4105CDH	Citrulline--aspartate ligase
GCD22_00490	ENOG4105DBV	ornithine carbamoyltransferase
GCD22_00491	ENOG4105C8Y	Acetylornithine aminotransferase
GCD22_00492	ENOG4105CFH	Aspartokinase
GCD22_00494	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
GCD22_00495	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
GCD22_00496	ENOG4105E9H	Lytic Murein transglycosylase
GCD22_00514	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
GCD22_00516	ENOG4108HMX	isocitrate dehydrogenase (NADP)
GCD22_00517	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
GCD22_00519	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
GCD22_00520	ENOG4105C4K	Nad synthetase
GCD22_00521	ENOG4108YZA	Nitrogen regulatory protein pii
GCD22_00522	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCD22_00523	ENOG4105C34	Pseudouridine synthase
GCD22_00524	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
GCD22_00525	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
GCD22_00526	ENOG4107RAT	Ribulose bisphosphate carboxylase large chain, catalytic domain
GCD22_00527	ENOG41080FP	Hydrolase
GCD22_00528	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
GCD22_00530	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
GCD22_00532	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
GCD22_00536	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
GCD22_00537	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
GCD22_00538	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
GCD22_00540	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GCD22_00542	ENOG4107WP9	Histidine kinase
GCD22_00543	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
GCD22_00544	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
GCD22_00545	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
GCD22_00546	ENOG4108EKN	Biotin protein ligase C terminal domain
GCD22_00547	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
GCD22_00548	ENOG4105DJF	DNA polymerase III, delta' subunit
GCD22_00550	ENOG4105C8T	Leucyl-tRNA synthetase
GCD22_00551	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
GCD22_00554	ENOG4105CVR	type I restriction-modification system
GCD22_00556	ENOG4108F3G	Type I restriction-modification system, R subunit
GCD22_00560	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
GCD22_00561	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
GCD22_00562	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
GCD22_00563	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GCD22_00564	ENOG4105EEI	dihydropteroate synthase
GCD22_00565	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
GCD22_00566	ENOG4105CP7	Triose-phosphate isomerase
GCD22_00569	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GCD22_00570	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GCD22_00571	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GCD22_00572	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GCD22_00575	ENOG4108IEH	NADH dehydrogenase subunit g
GCD22_00576	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
GCD22_00577	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GCD22_00578	ENOG4105DF2	NADH dehydrogenase subunit j
GCD22_00579	ENOG41080FQ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GCD22_00581	ENOG4105C8S	subunit m
GCD22_00582	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GCD22_00585	ENOG4105C22	threonyL-tRNA synthetase
GCD22_00586	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
GCD22_00587	ENOG41082NX	50s ribosomal protein l35
GCD22_00588	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
GCD22_00589	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
GCD22_00590	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
GCD22_00591	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
GCD22_00617	ENOG4105VT3	DNA binding domain protein, excisionase family
GCD22_00634	ENOG4105PF0	Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin
GCD22_00660	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
GCD22_00673	ENOG4108TWJ	NADH dehydrogenase subunit 5
GCD22_00676	ENOG4105EKE	dihydroorotase
GCD22_00688	ENOG4105FA0	parb-like partition protein
GCD22_00698	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
GCD22_00701	ENOG4107RRE	RNA-directed DNA polymerase
GCD22_00706	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
GCD22_00708	ENOG4108JQB	penicillin-binding protein 1C
GCD22_00716	ENOG4105KT5	UmuD protein
GCD22_00717	ENOG4107QTZ	amino acid
GCD22_00722	ENOG4105C85	amino acid
GCD22_00754	ENOG4105VEQ	Cold shock protein
GCD22_00755	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GCD22_00756	ENOG4105C25	Primosomal protein n'
GCD22_00757	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
GCD22_00758	ENOG410807V	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
GCD22_00759	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
GCD22_00761	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
GCD22_00762	ENOG4105C9A	Phoh family
GCD22_00764	ENOG4108JU5	Magnesium and cobalt efflux protein
GCD22_00765	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
GCD22_00766	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
GCD22_00770	ENOG4108UQY	Iron-storage protein
GCD22_00772	ENOG4105CKI	cobalamin synthesis protein
GCD22_00782	ENOG4105FDK	ABC transporter
GCD22_00784	ENOG4105CC5	ABC transporter
GCD22_00791	ENOG4105F2W	methyltransferase
GCD22_00792	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
GCD22_00794	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
GCD22_00796	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
GCD22_00797	ENOG4105E66	phosphoriboisomerase A
GCD22_00799	ENOG4105E2S	oxidase) subunit II
GCD22_00800	ENOG4105BZ9	Cytochrome C oxidase, subunit I
GCD22_00801	ENOG4105CCU	oxidase (Subunit III)
GCD22_00804	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
GCD22_00805	ENOG4107RDB	Major Facilitator
GCD22_00806	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
GCD22_00807	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
GCD22_00808	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
GCD22_00809	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
GCD22_00812	ENOG4105KAV	tspo and mbr like protein
GCD22_00816	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GCD22_00824	ENOG4105I08	Pseudouridine synthase
GCD22_00826	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
GCD22_00827	ENOG4105C3G	gtp-binding protein
GCD22_00828	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
GCD22_00829	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
GCD22_00830	ENOG4105CJN	penicillin-binding protein
GCD22_00832	ENOG4105D7V	transposase
GCD22_00834	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
GCD22_00837	ENOG4105CHJ	isochorismatase hydrolase
GCD22_00838	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
GCD22_00842	ENOG41081QV	Universal stress protein
GCD22_00843	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
GCD22_00848	ENOG4108TJN	glycosyl transferase group 1
GCD22_00851	ENOG4108DMA	Nad-dependent epimerase dehydratase
GCD22_00852	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
GCD22_00861	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
GCD22_00862	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
GCD22_00863	ENOG4105BZU	Histidine kinase
GCD22_00864	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GCD22_00867	ENOG4105FE1	phytoene synthase
GCD22_00869	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
GCD22_00877	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GCD22_00880	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
GCD22_00881	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
GCD22_00882	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
GCD22_00887	ENOG4105E2S	oxidase) subunit II
GCD22_00888	ENOG4105BZ9	Cytochrome C oxidase, subunit I
GCD22_00889	ENOG4105CCU	oxidase (Subunit III)
GCD22_00892	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
GCD22_00897	ENOG4105CGH	5'-nucleotidase
GCD22_00899	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
GCD22_00901	ENOG41088H4	Diheme cytochrome SoxA (Sulfur oxidation)
GCD22_00902	ENOG4105CRE	cytochrome C
GCD22_00907	ENOG4107RIQ	Sulfate adenylate transferase
GCD22_00908	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
GCD22_00912	ENOG4105E7D	Protein of unknown function (DUF3375)
GCD22_00940	ENOG4105VTW	prevent-host-death family
GCD22_00941	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
GCD22_00944	ENOG4105D85	methylase
GCD22_00946	ENOG4105F6A	helicase
GCD22_00947	ENOG4105ECI	YeeC-like protein
GCD22_00961	ENOG4105DZ1	carboxypeptidase
GCD22_00962	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GCD22_00969	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
GCD22_00970	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
GCD22_00971	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GCD22_00972	ENOG4105VCC	30S ribosomal protein S21
GCD22_00974	ENOG4105C98	muts2 protein
GCD22_00975	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
GCD22_00976	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GCD22_00978	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
GCD22_00980	ENOG4105CD8	aminopeptidase N
GCD22_00985	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
GCD22_00988	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
GCD22_00991	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
GCD22_00992	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
GCD22_00993	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
GCD22_00994	ENOG4107QJR	hflk protein
GCD22_00996	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
GCD22_01003	ENOG4105F1S	paraquat-inducible protein a
GCD22_01004	ENOG4105BZU	Histidine kinase
GCD22_01007	ENOG4105ERU	peptidase
GCD22_01008	ENOG4105M00	molybdopterin converting factor, subunit 1
GCD22_01009	ENOG4108ZAF	Molybdopterin
GCD22_01011	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
GCD22_01013	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCD22_01014	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCD22_01015	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
GCD22_01018	ENOG4105BZ1	(ABC) transporter
GCD22_01019	ENOG4108Z4U	Ferredoxin
GCD22_01020	ENOG4105D3R	alkyl hydroperoxide reductase
GCD22_01023	ENOG4105IPI	Membrane
GCD22_01026	ENOG4105C2N	RNA methyltransferase TrmH family group 3
GCD22_01027	ENOG4105F8V	Hydrolase, tatD family
GCD22_01028	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
GCD22_01031	ENOG4108JJ9	ABC, transporter
GCD22_01032	ENOG4108JJ8	(ABC) transporter
GCD22_01035	ENOG4108IYU	L-aspartate oxidase
GCD22_01036	ENOG4105EMN	RNA polymerase sigma factor
GCD22_01039	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
GCD22_01040	ENOG4105C3F	Signal peptidase i
GCD22_01043	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
GCD22_01044	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
GCD22_01045	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
GCD22_01046	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
GCD22_01047	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
GCD22_01048	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
GCD22_01049	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
GCD22_01050	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
GCD22_01051	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
GCD22_01058	ENOG41082GS	50S ribosomal protein L32
GCD22_01059	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
GCD22_01060	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
GCD22_01061	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
GCD22_01062	ENOG4105CHR	reductase
GCD22_01063	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
GCD22_01064	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
GCD22_01066	ENOG4105HHA	aminodeoxychorismate lyase
GCD22_01068	ENOG4107QRG	dna polymerase iii
GCD22_01075	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
GCD22_01077	ENOG4105VN1	Heat shock protein
GCD22_01091	ENOG4105CPW	cytochrome b561
GCD22_01095	ENOG4105DJ9	glucan biosynthesis protein
GCD22_01105	ENOG4105CW7	secretion protein, HlyD family
GCD22_01108	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GCD22_01112	ENOG4107QMP	dna polymerase iii subunits gamma and tau
GCD22_01114	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
GCD22_01116	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
GCD22_01117	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
GCD22_01119	ENOG4105K8N	protein family UPF0079, ATPase
GCD22_01120	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
GCD22_01121	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
GCD22_01123	ENOG4105DSW	Fusaric acid resistance protein
GCD22_01125	ENOG4105Y49	secretion protein, HlyD family
GCD22_01126	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
GCD22_01127	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
GCD22_01128	ENOG4105EJG	cellulose synthase
GCD22_01130	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
GCD22_01131	ENOG4105CUT	histidyl-tRNA synthetase
GCD22_01134	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
GCD22_01139	ENOG4105C8U	phosphate abc transporter
GCD22_01145	ENOG4105EKE	dihydroorotase
GCD22_01151	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
GCD22_01155	ENOG4105C98	muts2 protein
GCD22_01156	ENOG4105CQB	FAD linked oxidase domain protein
GCD22_01157	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
GCD22_01158	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
GCD22_01160	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GCD22_01161	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
GCD22_01162	ENOG4105DJ0	Poly(A) Polymerase
GCD22_01167	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GCD22_01168	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
GCD22_01170	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
GCD22_01175	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
GCD22_01176	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
GCD22_01177	ENOG4108Z4T	Peptidase M50
GCD22_01178	ENOG4105C31	Tryptophanyl-tRNA synthetase
GCD22_01179	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
GCD22_01180	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
GCD22_01182	ENOG4105FE9	pseudouridine synthase
GCD22_01185	ENOG4105EC8	Methyl-accepting chemotaxis
GCD22_01186	ENOG4107R88	Chemotaxis protein (CheV)
GCD22_01187	ENOG4108N3W	hemolysin secretion protein
GCD22_01191	ENOG4105CBS	Chea signal transduction histidine kinase
GCD22_01193	ENOG4108VYJ	response regulator receiver protein
GCD22_01194	ENOG4108SEK	ompa motb domain protein
GCD22_01196	ENOG41085EG	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
GCD22_01197	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
GCD22_01201	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
GCD22_01202	ENOG4108ZC9	flagellar basal-body rod protein flgc
GCD22_01203	ENOG4105W00	Flagellar hook capping protein
GCD22_01204	ENOG4105BZE	flagellar hook protein, FlgE
GCD22_01205	ENOG4108KPB	Flagellar basal-body rod protein FlgF
GCD22_01206	ENOG4105CGA	flagellar basal-body rod protein FlgG
GCD22_01208	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
GCD22_01209	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
GCD22_01211	ENOG4105E1Q	flagellar hook-associated protein
GCD22_01212	ENOG4105DTJ	flagellar hook-associated protein
GCD22_01217	ENOG4105I03	Flagellin
GCD22_01221	ENOG4105MQ3	flagellar protein FliS
GCD22_01223	ENOG4108JUA	Transcriptional regulator
GCD22_01224	ENOG4105BZU	Histidine kinase
GCD22_01226	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
GCD22_01227	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
GCD22_01228	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
GCD22_01230	ENOG4108JIR	Flagellum-specific ATP synthase
GCD22_01233	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
GCD22_01234	ENOG4105DD5	Flagellar motor switch protein
GCD22_01235	ENOG4105K0P	flagellar biosynthesis protein
GCD22_01236	ENOG4105CN7	Flagellar biosynthetic protein FliP
GCD22_01237	ENOG4105VS8	Flagellar biosynthetic protein fliq
GCD22_01238	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
GCD22_01240	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
GCD22_01241	ENOG4105D00	flagellar biosynthetic protein flhB
GCD22_01242	ENOG4105D7B	Flagellar biosynthesis protein flha
GCD22_01243	ENOG4105FZW	flagellar biosynthesis regulator FlhF
GCD22_01245	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GCD22_01248	ENOG4105BZU	Histidine kinase
GCD22_01250	ENOG4105BZU	Histidine kinase
GCD22_01253	ENOG4107RD7	Flagellar Motor Protein, MotA
GCD22_01254	ENOG4105ER2	Ompa motb domain protein
GCD22_01255	ENOG4105BZU	Histidine kinase
GCD22_01257	ENOG4105D58	Diguanylate phosphodiesterase
GCD22_01258	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
GCD22_01262	ENOG4105VM1	flagellar
GCD22_01265	ENOG41075W9	High frequency lysogenization protein HflD homolog
GCD22_01266	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
GCD22_01267	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
GCD22_01268	ENOG4105PW4	Sugar fermentation stimulation protein homolog
GCD22_01269	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
GCD22_01270	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
GCD22_01271	ENOG4108ZAI	phosphatidylglycerophosphatase a
GCD22_01273	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
GCD22_01274	ENOG4105Y3E	Modulates RecA activity (By similarity)
GCD22_01275	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
GCD22_01278	ENOG4105WH9	RNA polymerase
GCD22_01283	ENOG4107SC1	transglycosylase
GCD22_01287	ENOG4105C0D	helicase
GCD22_01288	ENOG4106ECQ	phosphomannomutase
GCD22_01290	ENOG4105C5H	ABC transporter
GCD22_01291	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
GCD22_01294	ENOG4105C4M	(Ubiquinol oxidase) subunit I
GCD22_01300	ENOG4105DC8	reductase
GCD22_01304	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
GCD22_01307	ENOG4105M08	Membrane
GCD22_01309	ENOG4105C54	Major Facilitator superfamily
GCD22_01310	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
GCD22_01314	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
GCD22_01315	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
GCD22_01318	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
GCD22_01319	ENOG4107S2Z	UPF0761 membrane protein
GCD22_01321	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
GCD22_01322	ENOG4105MFQ	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity)
GCD22_01323	ENOG4105FD8	phosphonate metabolism protein PhnM
GCD22_01324	ENOG4105HRV	phosphonate c-p lyase system protein phnl
GCD22_01325	ENOG4105ENV	phosphonate C-P lyase system protein PhnK
GCD22_01326	ENOG4105FT8	Phosphonate metabolism
GCD22_01328	ENOG4105KZ6	phosphonate C-P lyase system protein PhnH
GCD22_01330	ENOG4105C54	Major Facilitator superfamily
GCD22_01333	ENOG4105HSS	phospholipase C
GCD22_01336	ENOG4105M8F	Biopolymer transport protein exbD tolR
GCD22_01343	ENOG4105PGM	cation diffusion facilitator family transporter
GCD22_01347	ENOG4107S5T	Carbohydrate kinase
GCD22_01348	ENOG4107YRI	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
GCD22_01349	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
GCD22_01353	ENOG4105DA5	(ABC) transporter
GCD22_01355	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
GCD22_01356	ENOG4105KCK	Peptidoglycan-associated lipoprotein
GCD22_01358	ENOG41079KZ	Major Facilitator Superfamily
GCD22_01359	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
GCD22_01360	ENOG4105CJN	penicillin-binding protein
GCD22_01361	ENOG4105PF0	Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin
GCD22_01363	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GCD22_01364	ENOG4108IAB	Phoh family
GCD22_01365	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
GCD22_01377	ENOG4105J0Q	Transcriptional regulator
GCD22_01379	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
GCD22_01384	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
GCD22_01386	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
GCD22_01387	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
GCD22_01388	ENOG41080RH	Thioredoxin
GCD22_01392	ENOG4105EU0	Major facilitator Superfamily
GCD22_01393	ENOG41084YM	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
GCD22_01394	ENOG4105CTB	Polyprenyl synthetase
GCD22_01395	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
GCD22_01396	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
GCD22_01397	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
GCD22_01399	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
GCD22_01400	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GCD22_01402	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
GCD22_01412	ENOG4105CFU	surface antigen
GCD22_01414	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
GCD22_01418	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
GCD22_01419	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
GCD22_01421	ENOG4105E18	UPF0276 protein
GCD22_01425	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
GCD22_01428	ENOG4107RDB	Major Facilitator
GCD22_01430	ENOG4107TPS	domain protein
GCD22_01434	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
GCD22_01440	ENOG41082CH	UPF0145 protein
GCD22_01461	ENOG4105F1S	paraquat-inducible protein a
GCD22_01468	ENOG4105C4M	(Ubiquinol oxidase) subunit I
GCD22_01473	ENOG4105RQ5	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GCD22_01482	ENOG4105DUM	transcriptional regulator, lysR family
GCD22_01483	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GCD22_01488	ENOG4108KDI	dmso reductase anchor subunit
GCD22_01489	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
GCD22_01490	ENOG4105DB1	molybdopterin oxidoreductase
GCD22_01501	ENOG4106AKX	UPF0229 protein
GCD22_01510	ENOG4105D7V	transposase
GCD22_01548	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GCD22_01553	ENOG4105CRU	nitrate reductase, alpha subunit
GCD22_01554	ENOG4108IUE	nitrate reductase beta subunit
GCD22_01556	ENOG41076YT	nitrate reductase, gamma subunit
GCD22_01565	ENOG4108UR0	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GCD22_01567	ENOG4105K78	MarR family Transcriptional regulator
GCD22_01573	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GCD22_01579	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
GCD22_01580	ENOG4105D03	DNA-3-methyladenine glycosylase II
GCD22_01583	ENOG4108Z4U	Ferredoxin
GCD22_01590	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GCD22_01594	ENOG4105C89	phosphohexose isomerase
GCD22_01597	ENOG4105D7V	transposase
GCD22_01598	ENOG4105D7V	transposase
GCD22_01603	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
GCD22_01628	ENOG4105CQR	helicase
GCD22_01634	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
GCD22_01637	ENOG4108R1E	Serine threonine protein phosphatase 1
GCD22_01656	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GCD22_01657	ENOG4105VEQ	Cold shock protein
GCD22_01658	ENOG4107QHF	type ii secretion system protein e
GCD22_01659	ENOG4105E4G	Type IV pilus
GCD22_01694	ENOG4105BZU	Histidine kinase
GCD22_01697	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
GCD22_01701	ENOG4105CZX	twitching motility protein
GCD22_01707	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
GCD22_01713	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
GCD22_01717	ENOG4107TPS	domain protein
GCD22_01719	ENOG4107RDB	Major Facilitator
GCD22_01722	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
GCD22_01726	ENOG4105E18	UPF0276 protein
GCD22_01729	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
GCD22_01730	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
GCD22_01731	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
GCD22_01754	ENOG410600T	transposase
GCD22_01758	ENOG41082IR	Excinuclease ABC C subunit domain protein
GCD22_01763	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GCD22_01765	ENOG4105DXD	2-methylcitrate dehydratase
GCD22_01767	ENOG4108KB2	LysR family Transcriptional regulator
GCD22_01770	ENOG4105CB5	ATP-dependent DNA helicase recG
GCD22_01782	ENOG4105C4R	Atp-dependent dna helicase
GCD22_01793	ENOG4105DPX	Hydrogenase, large subunit
GCD22_01801	ENOG41083MR	nifu domain-containing protein
GCD22_01803	ENOG4105C8H	hydrogenase maturation protein Hypf
GCD22_01805	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
GCD22_01806	ENOG4105CQS	hydrogenase expression formation protein HypD
GCD22_01807	ENOG4105C45	hydrogenase expression formation protein (HypE)
GCD22_01808	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
GCD22_01809	ENOG4107RSS	Hydrogenase accessory protein HypB
GCD22_01825	ENOG4105D7V	transposase
GCD22_01835	ENOG410600T	transposase
GCD22_01858	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
GCD22_01896	ENOG4107QHF	type ii secretion system protein e
GCD22_01902	ENOG4105C4R	Atp-dependent dna helicase
GCD22_01906	ENOG4108UUM	single-stranded DNA-binding protein
GCD22_01910	ENOG4105D7V	transposase
GCD22_01948	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
GCD22_01954	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
GCD22_01973	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
GCD22_02001	ENOG4108TWJ	NADH dehydrogenase subunit 5
GCD22_02021	ENOG4105EJ9	Membrane
GCD22_02029	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GCD22_02034	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
GCD22_02047	ENOG4108KSB	HipA-like N-terminal domain
GCD22_02048	ENOG4105UKP	Protein of unknown function (DUF1778)
GCD22_02055	ENOG4107QWP	ABC-2 type transporter
GCD22_02056	ENOG4107QWP	ABC-2 type transporter
GCD22_02057	ENOG4105CJ1	ABC, transporter
GCD22_02059	ENOG4105DFG	type I secretion outer membrane protein
GCD22_02062	ENOG410904A	RNA polymerase
GCD22_02066	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
GCD22_02067	ENOG4105C4M	(Ubiquinol oxidase) subunit I
GCD22_02069	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
GCD22_02074	ENOG4108JYK	Dehydrogenase
GCD22_02076	ENOG4105C7S	Dehydrogenase
GCD22_02077	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
GCD22_02078	ENOG4107QYA	phosphate
GCD22_02079	ENOG4105DE4	1-phosphofructokinase
GCD22_02082	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
GCD22_02084	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
GCD22_02085	ENOG4107QNK	)-transporter
GCD22_02088	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
GCD22_02091	ENOG4105C4M	(Ubiquinol oxidase) subunit I
GCD22_02093	ENOG4105CSR	polyphosphate kinase 2
GCD22_02098	ENOG41068D6	Glycosyltransferase
GCD22_02103	ENOG4105BZU	Histidine kinase
GCD22_02105	ENOG4105WDR	
GCD22_02107	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
GCD22_02108	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
GCD22_02112	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
GCD22_02113	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
GCD22_02115	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
GCD22_02116	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GCD22_02117	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
GCD22_02118	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
GCD22_02119	ENOG4105C0B	DNA polymerase III (alpha subunit)
GCD22_02120	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
GCD22_02124	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
GCD22_02125	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
GCD22_02126	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
GCD22_02128	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCD22_02130	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
GCD22_02131	ENOG4105KNE	Phosphatidate cytidylyltransferase
GCD22_02132	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
GCD22_02133	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
GCD22_02134	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
GCD22_02135	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
GCD22_02136	ENOG4105CE9	30S ribosomal protein S2
GCD22_02138	ENOG4105C9X	ppx gppa phosphatase
GCD22_02139	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
GCD22_02140	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
GCD22_02141	ENOG4105BZU	Histidine kinase
GCD22_02142	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
GCD22_02143	ENOG4105C1J	atp-dependent rna helicase
GCD22_02144	ENOG4105CPC	Aldo Keto reductase
GCD22_02145	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
GCD22_02147	ENOG4108ZIT	Ferredoxin, 2FE-2S
GCD22_02148	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
GCD22_02149	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
GCD22_02150	ENOG4108Z4V	iron-sulfur cluster assembly
GCD22_02151	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
GCD22_02152	ENOG4105C3J	Cysteine desulfurase
GCD22_02153	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
GCD22_02154	ENOG4105D7W	serine acetyltransferase
GCD22_02156	ENOG4105ECY	inositol monophosphatase
GCD22_02159	ENOG4105K9H	YciI-like protein
GCD22_02161	ENOG4107QZM	n-acetylglutamate synthase
GCD22_02163	ENOG4105C01	Dihydroxy-acid dehydratase
GCD22_02164	ENOG4105IPI	Membrane
GCD22_02165	ENOG4105C6K	Malic enzyme
GCD22_02166	ENOG4105VFB	Binds the 23S rRNA (By similarity)
GCD22_02167	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
GCD22_02168	ENOG4105K63	Thioredoxin
GCD22_02171	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GCD22_02177	ENOG4105D06	uba thif-type nad fad binding protein
GCD22_02181	ENOG4105CY3	ABC transporter, permease
GCD22_02182	ENOG4105DHJ	ABC, transporter
GCD22_02183	ENOG4105DFU	Cell wall formation (By similarity)
GCD22_02185	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
GCD22_02186	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
GCD22_02194	ENOG4108MX3	Polysaccharide Biosynthesis Protein
GCD22_02195	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
GCD22_02200	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
GCD22_02201	ENOG41066UM	arsR family transcriptional regulator
GCD22_02205	ENOG4105C4R	Atp-dependent dna helicase
GCD22_02207	ENOG41082GY	Binds directly to 16S ribosomal RNA (By similarity)
GCD22_02208	ENOG4105C26	Dehydrogenase
GCD22_02211	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
GCD22_02214	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
GCD22_02215	ENOG4105C9U	ATP-dependent DNA helicase RecQ
GCD22_02216	ENOG41087PB	Frataxin-like domain
GCD22_02221	ENOG410890F	Dynamin family
GCD22_02223	ENOG4108M8S	permease YjgP YjgQ family protein
GCD22_02224	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
GCD22_02227	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
GCD22_02228	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
GCD22_02229	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
GCD22_02230	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
GCD22_02234	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
GCD22_02235	ENOG4108594	Permease of the drug metabolite transporter
GCD22_02255	ENOG4105E18	UPF0276 protein
GCD22_02257	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
GCD22_02260	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
GCD22_02266	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
GCD22_02267	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
GCD22_02275	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
GCD22_02276	ENOG4108426	dNA-binding protein
GCD22_02280	ENOG4105BZU	Histidine kinase
GCD22_02282	ENOG4105BZU	Histidine kinase
GCD22_02284	ENOG4105C8Q	Methyl-accepting chemotaxis
GCD22_02293	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
GCD22_02294	ENOG4105EI2	Pseudouridine synthase
GCD22_02296	ENOG4107QQB	Ribonuclease E
GCD22_02297	ENOG4105C8N	cysteinyl-tRNA synthetase
GCD22_02298	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
GCD22_02299	ENOG4108JQC	penicillin-binding protein 1A
GCD22_02300	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
GCD22_02312	ENOG4108VCT	Sulfite exporter TauE/SafE
GCD22_02314	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
GCD22_02317	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
GCD22_02321	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCD22_02324	ENOG4105IPI	Membrane
GCD22_02343	ENOG4108JUA	Transcriptional regulator
GCD22_02350	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
GCD22_02353	ENOG4108VY7	phosphate-starvation-inducible protein PsiE
GCD22_02370	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
GCD22_02371	ENOG4105EY8	ABC transporter
GCD22_02378	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
GCD22_02380	ENOG4108TJN	glycosyl transferase group 1
GCD22_02387	ENOG41084CK	capsule polysaccharide
GCD22_02398	ENOG4105ECX	polysaccharide export
GCD22_02404	ENOG4105K4H	Nlp p60 protein
GCD22_02406	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
GCD22_02407	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
GCD22_02410	ENOG4105CHM	Aminotransferase
GCD22_02412	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
GCD22_02413	ENOG4105K6T	rare lipoprotein A
GCD22_02416	ENOG4105EIN	peptidylprolyl cis-trans isomerase
GCD22_02419	ENOG4105K70	DNA-binding protein
GCD22_02420	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
GCD22_02421	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
GCD22_02422	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
GCD22_02423	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
GCD22_02424	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
GCD22_02425	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
GCD22_02426	ENOG4105CFV	Tetratricopeptide repeat protein
GCD22_02427	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
GCD22_02428	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
GCD22_02429	ENOG4105CAT	Cytidine monophosphate kinase
GCD22_02430	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
GCD22_02432	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
GCD22_02433	ENOG4105CIH	Imidazole acetol-phosphate transaminase
GCD22_02434	ENOG4105CQC	Prephenate dehydratase
GCD22_02435	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
GCD22_02436	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
GCD22_02437	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
GCD22_02438	ENOG4105DR4	Methyltransferase
GCD22_02442	ENOG4105FA0	parb-like partition protein
GCD22_02443	ENOG4107QJE	Chromosome Partitioning Protein
GCD22_02480	ENOG4107SC1	transglycosylase
GCD22_02516	ENOG4108115	UPF0145 protein
GCD22_02528	ENOG4105EXC	Acyl-transferase
GCD22_02529	ENOG4108UUM	single-stranded DNA-binding protein
GCD22_02545	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
GCD22_02565	ENOG4108NF7	phage-type endonuclease
GCD22_02571	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
GCD22_02572	ENOG4105KT5	UmuD protein
GCD22_02577	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
GCD22_02590	ENOG4105DZR	Type I site-specific deoxyribonuclease
GCD22_02593	ENOG4108RPX	mosc domain containing protein
GCD22_02597	ENOG4105C7H	Helicase, RecD TraA family
GCD22_02600	ENOG4105BZU	Histidine kinase
GCD22_02607	ENOG4108NF7	phage-type endonuclease
GCD22_02619	ENOG4105W1Y	Transcriptional regulator
GCD22_02628	ENOG4105BZ1	(ABC) transporter
GCD22_02629	ENOG4105DSB	aldose 1-epimerase
GCD22_02633	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
GCD22_02635	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
GCD22_02636	ENOG41080HT	Transcriptional regulator, arsr family
GCD22_02658	ENOG4105C4M	(Ubiquinol oxidase) subunit I
GCD22_02663	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
GCD22_02664	ENOG4105D03	DNA-3-methyladenine glycosylase II
GCD22_02669	ENOG4108Z4U	Ferredoxin
GCD22_02671	ENOG4108K3A	Glutathione S-transferase
GCD22_02674	ENOG4105CRU	nitrate reductase, alpha subunit
GCD22_02675	ENOG4108IUE	nitrate reductase beta subunit
GCD22_02676	ENOG41076YT	nitrate reductase, gamma subunit
GCD22_02685	ENOG4105RQ5	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GCD22_02687	ENOG4105FA0	parb-like partition protein
GCD22_02688	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
GCD22_02701	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
GCD22_02706	ENOG4105E18	UPF0276 protein
GCD22_02708	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
GCD22_02711	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
GCD22_02727	ENOG4105C8Q	Methyl-accepting chemotaxis
GCD22_02729	ENOG4105BZU	Histidine kinase
GCD22_02735	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GCD22_02736	ENOG4105D74	hydrolase
GCD22_02763	ENOG4105DFG	type I secretion outer membrane protein
GCD22_02764	ENOG4107RDB	Major Facilitator
GCD22_02765	ENOG4105CMQ	Chloride channel
GCD22_02767	ENOG4105EGI	Transcriptional regulator
GCD22_02768	ENOG4105C02	permease
GCD22_02769	ENOG4105C1Q	protoporphyrinogen oxidase
GCD22_02771	ENOG4105CB5	ATP-dependent DNA helicase recG
GCD22_02773	ENOG4105KME	endoribonuclease L-psp
GCD22_02774	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
GCD22_02775	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
GCD22_02776	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
GCD22_02777	ENOG4105DSJ	YicC domain protein
GCD22_02787	ENOG4105D65	subunit l
GCD22_02792	ENOG4108UQY	Iron-storage protein
GCD22_02793	ENOG4105KNY	Microcompartments protein
GCD22_02794	ENOG4105KNY	Microcompartments protein
GCD22_02795	ENOG4105KNY	Microcompartments protein
GCD22_02801	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
GCD22_02803	ENOG4105CJR	Integral membrane protein (MviN
GCD22_02805	ENOG4105DTN	riboflavin biosynthesis protein ribF
GCD22_02806	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
GCD22_02807	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
GCD22_02817	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
GCD22_02818	ENOG4105CM2	brancheD-chain amino acid aminotransferase
GCD22_02821	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
GCD22_02823	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
GCD22_02824	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
GCD22_02831	ENOG4107R8N	Glycosyl transferase, family 2
GCD22_02834	ENOG4105BZU	Histidine kinase
GCD22_02846	ENOG4105DFP	Integrase
GCD22_02864	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
GCD22_02865	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
GCD22_02866	ENOG4105VIE	preprotein translocase, subunit YajC
GCD22_02867	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
GCD22_02868	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
GCD22_02869	ENOG4105C37	(CBS) domain
GCD22_02871	ENOG4105C28	cystathionine
GCD22_02874	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
GCD22_02875	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
GCD22_02876	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
GCD22_02877	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
GCD22_02878	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
GCD22_02879	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
GCD22_02881	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
GCD22_02882	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
GCD22_02884	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
GCD22_02885	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
GCD22_02886	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
GCD22_02889	ENOG4105FQ6	thiopurine methyltransferase
GCD22_02890	ENOG4108PTX	LysR family Transcriptional regulator
GCD22_02891	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GCD22_02893	ENOG4105CW7	secretion protein, HlyD family
GCD22_02898	ENOG4105RQ5	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GCD22_02900	ENOG4105K78	MarR family Transcriptional regulator
GCD22_02901	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
GCD22_02916	ENOG4105DHQ	Histidine kinase
GCD22_02917	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
GCD22_02924	ENOG4105E3B	Multicopper oxidase
GCD22_02932	ENOG4108IJF	Heavy metal efflux pump, CzcA
GCD22_02934	ENOG4107QTZ	amino acid
GCD22_02938	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
GCD22_02939	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
GCD22_02941	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
GCD22_02942	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
GCD22_02943	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
GCD22_02944	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
GCD22_02945	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
GCD22_02946	ENOG4105DQ4	alcohol dehydrogenase
GCD22_02949	ENOG41085FC	arsR family transcriptional regulator
GCD22_02950	ENOG4108UXE	Protein tyrosine phosphatase
GCD22_02952	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
GCD22_02955	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
GCD22_02956	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
GCD22_02958	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
GCD22_02959	ENOG4108ZP8	Acetolactate synthase small subunit
GCD22_02960	ENOG4105C7K	acetolactate synthase
GCD22_02961	ENOG4105C98	muts2 protein
GCD22_02964	ENOG4108Z6B	deaminase
GCD22_02969	ENOG4105E4G	Type IV pilus
GCD22_02970	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
GCD22_02971	ENOG4105D49	3-dehydroquinate synthase
GCD22_02972	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
GCD22_02974	ENOG4105CBC	glutamate synthase
GCD22_02975	ENOG4105BZ8	glutamate synthase
GCD22_02976	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
GCD22_02977	ENOG4108Z20	Acyl-transferase
GCD22_02981	ENOG4105F4R	Transcriptional regulator mode
GCD22_02982	ENOG4105C7B	Threonine dehydratase
GCD22_02984	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
GCD22_02985	ENOG4105K64	Glycosyl transferase, family 2
GCD22_02987	ENOG4107TYR	Glycosyl Transferase
GCD22_02992	ENOG4108MX3	Polysaccharide Biosynthesis Protein
GCD22_02997	ENOG4105E2K	Glycosyl transferase (Group 1
GCD22_02999	ENOG4105D3Q	Sugar transferase
GCD22_03000	ENOG4105DC1	bifunctional purine biosynthesis protein purh
GCD22_03001	ENOG4105C12	Phosphoribosylglycinamide synthetase
GCD22_03002	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
GCD22_03003	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
GCD22_03004	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
GCD22_03006	ENOG4105C54	Major Facilitator superfamily
GCD22_03008	ENOG4105HSS	phospholipase C
GCD22_03010	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
GCD22_03011	ENOG4105BZS	acriflavin resistance protein
GCD22_03018	ENOG4105M8F	Biopolymer transport protein exbD tolR
GCD22_03021	ENOG41079KZ	Major Facilitator Superfamily
GCD22_03026	ENOG4105SG9	biopolymer transport protein, ExbD
GCD22_03030	ENOG4105E0F	Histidine kinase
GCD22_03031	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
GCD22_03033	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
GCD22_03039	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
GCD22_03068	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
GCD22_03070	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
GCD22_03071	ENOG4105C8V	SAICAR synthetase
GCD22_03074	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
GCD22_03078	ENOG4108UT2	hemolysin iii
GCD22_03079	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
GCD22_03081	ENOG4105VW4	glutaredoxin 3
GCD22_03082	ENOG41085GJ	domain protein
GCD22_03084	ENOG4105BZS	acriflavin resistance protein
GCD22_03085	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
GCD22_03088	ENOG41080HT	Transcriptional regulator, arsr family
GCD22_03091	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
GCD22_03094	ENOG4105CUZ	uba thif-type nad fad binding protein
GCD22_03095	ENOG4105EYA	deoxyribonuclease
GCD22_03096	ENOG4105D0A	hydroxylase
GCD22_03097	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
GCD22_03098	ENOG4105W0Z	cytoplasmic protein
GCD22_03099	ENOG4105C0P	Mg chelatase subunit ChlI
GCD22_03102	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
GCD22_03104	ENOG41072GX	Peptidase M22 Glycoprotease
GCD22_03105	ENOG4105DVT	helicase
GCD22_03107	ENOG4105CRE	cytochrome C
GCD22_03108	ENOG4105K4H	Nlp p60 protein
GCD22_03113	ENOG4105CE1	Ferrous iron transport protein b
GCD22_03117	ENOG4105DQR	SNARE associated Golgi
GCD22_03120	ENOG4105DUM	transcriptional regulator, lysR family
GCD22_03124	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
GCD22_03140	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
GCD22_03142	ENOG4105PHD	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GCD22_03144	ENOG4105RQ5	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GCD22_03145	ENOG41086B8	CoB-CoM heterodisulfide reductase
GCD22_03148	ENOG4105EWK	phytoene
GCD22_03151	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
GCD22_03152	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
GCD22_03154	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GCD22_03156	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
GCD22_03157	ENOG4105DB1	molybdopterin oxidoreductase
GCD22_03159	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GCD22_03161	ENOG4105CUX	Signal transduction histidine kinase
GCD22_03166	ENOG41088H4	Diheme cytochrome SoxA (Sulfur oxidation)
GCD22_03167	ENOG4105UUH	Domain of unknown function DUF302 
GCD22_03168	ENOG4105CGH	5'-nucleotidase
GCD22_03169	ENOG4105DFF	Rod shape-determining protein mreb
GCD22_03170	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
GCD22_03172	ENOG4105CNI	cell division protein FtsW
GCD22_03173	ENOG4105DZ1	carboxypeptidase
GCD22_03175	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
GCD22_03176	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
GCD22_03186	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
GCD22_03188	ENOG4107RIS	Acyl-transferase
GCD22_03189	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
GCD22_03196	ENOG4105WPN	DNA integration recombination invertion protein
GCD22_03198	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
GCD22_03201	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
GCD22_03202	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GCD22_03204	ENOG4108JUA	Transcriptional regulator
GCD22_03212	ENOG4105CDV	Ompa motb domain protein
GCD22_03216	ENOG4105SYT	Methylenetetrahydrofolate reductase
GCD22_03217	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
GCD22_03218	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
GCD22_03224	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
GCD22_03226	ENOG4105CN1	protease
GCD22_03227	ENOG4107S0N	DJ-1 family
GCD22_03230	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
GCD22_03231	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
GCD22_03232	ENOG4105CNG	UPF0061 protein
GCD22_03233	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
GCD22_03234	ENOG4105D3R	alkyl hydroperoxide reductase
GCD22_03237	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
GCD22_03238	ENOG4105W49	UPF0434 protein
GCD22_03239	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
GCD22_03242	ENOG4109015	Biopolymer transport protein exbD tolR
GCD22_03244	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
GCD22_03254	ENOG4105KK4	UPF0060 membrane protein
GCD22_03257	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
GCD22_03258	ENOG4105D60	lipoprotein releasing system transmembrane protein
GCD22_03259	ENOG4105CRK	lysyL-tRNA synthetase
GCD22_03260	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
GCD22_03264	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
GCD22_03267	ENOG4105D6E	homoserine dehydrogenase
GCD22_03268	ENOG4105CHM	Aminotransferase
GCD22_03270	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GCD22_03271	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
GCD22_03272	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
GCD22_03274	ENOG4105C5F	glutamine synthetase
GCD22_03279	ENOG4105EWK	phytoene
GCD22_03288	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
GCD22_03291	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
GCD22_03295	ENOG4105DHP	deoxycytidine triphosphate deaminase
GCD22_03298	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
GCD22_03299	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
GCD22_03300	ENOG4105CFG	Acts as a chaperone (By similarity)
GCD22_03301	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GCD22_03302	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
GCD22_03304	ENOG4105W0E	50S ribosomal protein L33
GCD22_03305	ENOG4105KDC	50s ribosomal protein l28
GCD22_03307	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
GCD22_03308	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
GCD22_03309	ENOG4105C9Q	fumarate hydratase class II
GCD22_03310	ENOG4105DPN	Oligoendopeptidase f
GCD22_03317	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
GCD22_03319	ENOG4105CSM	endonuclease III
GCD22_03321	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
GCD22_03325	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GCD22_03326	ENOG4108JPZ	Monovalent cation H antiporter subunit D
GCD22_03334	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
GCD22_03335	ENOG4105DUM	transcriptional regulator, lysR family
GCD22_03338	ENOG4105VZ9	UPF0235 protein
GCD22_03339	ENOG4105CHH	sulfate transporter
GCD22_03345	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
GCD22_03347	ENOG4105NWN	ApaG protein
GCD22_03348	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
GCD22_03357	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
GCD22_03358	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
GCD22_03359	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
GCD22_03361	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GCD22_03362	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
GCD22_03363	ENOG4105CAK	Cell division ATP-binding protein ftsE
GCD22_03364	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
GCD22_03365	ENOG4106H78	methyltransferase
GCD22_03366	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
GCD22_03367	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
GCD22_03368	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
GCD22_03369	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
GCD22_03370	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
GCD22_03371	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
GCD22_03372	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
GCD22_03375	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
GCD22_03377	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
GCD22_03382	ENOG41082CH	UPF0145 protein
GCD22_03396	ENOG4107RAQ	aminopeptidase
GCD22_03398	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
GCD22_03399	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
GCD22_03400	ENOG4105CDU	Replicative dna helicase
GCD22_03401	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
GCD22_03404	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
GCD22_03405	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
GCD22_03406	ENOG4105C0X	amino acid
GCD22_03408	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
GCD22_03412	ENOG4105C6T	cysteine synthase
GCD22_03417	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
GCD22_03418	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
GCD22_03420	ENOG4105C6W	4-alpha-glucanotransferase (EC 2.4.1.25)
GCD22_03421	ENOG4105DKQ	ROK family
GCD22_03425	ENOG4106BRA	Membrane
GCD22_03429	ENOG4108UUM	single-stranded DNA-binding protein
GCD22_03430	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
GCD22_03432	ENOG4107QR8	Thioredoxin
GCD22_03435	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
GCD22_03437	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
GCD22_03438	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
GCD22_03439	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
GCD22_03440	ENOG4105K5M	30s ribosomal protein S16
GCD22_03441	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GCD22_03462	ENOG4105WJ3	XRE family Transcriptional regulator
GCD22_03463	ENOG4105RT5	Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation
GCD22_03464	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
GCD22_03467	ENOG4105C5H	ABC transporter
GCD22_03470	ENOG4105CJN	penicillin-binding protein
GCD22_03475	ENOG4105EAH	synthase
GCD22_03477	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GCD22_03478	ENOG4105CUX	Signal transduction histidine kinase
GCD22_03486	ENOG4105CYN	Serine protein kinase
GCD22_03487	ENOG4105BZU	Histidine kinase
GCD22_03488	ENOG4106AKX	UPF0229 protein
GCD22_03489	ENOG4105ED1	spovr family
GCD22_03491	ENOG4108YZA	Nitrogen regulatory protein pii
GCD22_03492	ENOG4105BZU	Histidine kinase
GCD22_03500	ENOG4105CJN	penicillin-binding protein
GCD22_03502	ENOG4105K6T	rare lipoprotein A
GCD22_03504	ENOG4107SVH	Potassium channel protein
GCD22_03506	ENOG4105CJN	penicillin-binding protein
GCD22_03508	ENOG4105C0H	protease
GCD22_03509	ENOG4105DZ1	carboxypeptidase
GCD22_03510	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
GCD22_03519	ENOG4108JQC	penicillin-binding protein 1A
GCD22_03520	ENOG4105DZ1	carboxypeptidase
GCD22_03521	ENOG4105C89	phosphohexose isomerase
GCD22_03522	ENOG4105C4M	(Ubiquinol oxidase) subunit I
GCD22_03523	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
GCD22_03529	ENOG4107QK9	Beta-lactamase
GCD22_03534	ENOG4108JPZ	Monovalent cation H antiporter subunit D
GCD22_03536	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
GCD22_03537	ENOG4108JPZ	Monovalent cation H antiporter subunit D
GCD22_03538	ENOG4105WMR	Protein CrcB homolog
GCD22_03542	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
GCD22_03545	ENOG4105CC0	LysR family Transcriptional regulator
GCD22_03550	ENOG4105E18	UPF0276 protein
GCD22_03552	ENOG4105DSY	exodeoxyribonuclease V, gamma
GCD22_03553	ENOG4107QKA	exodeoxyribonuclease V beta
GCD22_03554	ENOG4107QYX	exodeoxyribonuclease v alpha
GCD22_03555	ENOG4105BZU	Histidine kinase
GCD22_03556	ENOG4105E0X	reductase
GCD22_03557	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
GCD22_03559	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
GCD22_03560	ENOG4105CMR	udp-glucose 4-epimerase
GCD22_03569	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
GCD22_03570	ENOG4105CQB	FAD linked oxidase domain protein
GCD22_03572	ENOG4105XA0	heptosyltransferase ii
GCD22_03575	ENOG4105DZ2	Transcriptional regulator
GCD22_03576	ENOG4105D4P	Coproporphyrinogen iii oxidase
GCD22_03577	ENOG4105KUZ	arsenate reductase
GCD22_03579	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
GCD22_03581	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
GCD22_03582	ENOG4107ZVW	dihydroneopterin aldolase
GCD22_03583	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
GCD22_03585	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
GCD22_03586	ENOG4105ED9	Protein of unknown function (DUF455)
GCD22_03587	ENOG4105C4M	(Ubiquinol oxidase) subunit I
GCD22_03588	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
GCD22_03595	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
GCD22_03596	ENOG4105E0F	Histidine kinase
GCD22_03597	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
GCD22_03598	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
GCD22_03604	ENOG4105CF1	Alkylated DNA repair protein
GCD22_03610	ENOG4108SB3	DoxX Family
GCD22_03612	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
GCD22_03624	ENOG4105VUH	addiction module killer protein
GCD22_03650	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
GCD22_03652	ENOG4105CH7	arginosuccinase
GCD22_03654	ENOG4105E0F	Histidine kinase
GCD22_03655	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
GCD22_03658	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
GCD22_03659	ENOG4105BZS	acriflavin resistance protein
GCD22_03661	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
GCD22_03663	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
GCD22_03664	ENOG4105CSR	polyphosphate kinase 2
GCD22_03665	ENOG4107QNK	)-transporter
GCD22_03666	ENOG4105D7N	magnesium and cobalt transport protein CorA
GCD22_03667	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
GCD22_03668	ENOG4105ECY	inositol monophosphatase
GCD22_03670	ENOG4105CV1	Transketolase (EC 2.2.1.1)
GCD22_03671	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
GCD22_03672	ENOG4105BZA	Phosphoglycerate kinase
GCD22_03673	ENOG4105CA9	Pyruvate kinase
GCD22_03674	ENOG4105D2N	Aldolase
GCD22_03675	ENOG4105DJV	ribulose-phosphate 3-epimerase
GCD22_03677	ENOG4105CRQ	synthase (Component I)
GCD22_03680	ENOG4105DDQ	anthranilate synthase
GCD22_03681	ENOG4108I0Q	anthranilate phosphoribosyltransferase
GCD22_03682	ENOG4105DK0	Indole-3-glycerol phosphate synthase
GCD22_03684	ENOG410847I	Transcriptional regulator, BadM Rrf2 family
GCD22_03685	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
GCD22_03687	ENOG4105DHZ	alpha beta
GCD22_03688	ENOG4105CJ1	ABC, transporter
GCD22_03696	ENOG4105K70	DNA-binding protein
GCD22_03699	ENOG41082CH	UPF0145 protein
GCD22_03708	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
GCD22_03723	ENOG4105VEQ	Cold shock protein
GCD22_03724	ENOG4106KE4	Dehydrogenase
GCD22_03725	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
GCD22_03727	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
GCD22_03728	ENOG4107QPD	alcohol dehydrogenase
GCD22_03729	ENOG4105C4W	S-formylglutathione hydrolase
GCD22_03730	ENOG4105C54	Major Facilitator superfamily
GCD22_03732	ENOG4105D52	delta-aminolevulinic acid dehydratase
GCD22_03734	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
GCD22_03735	ENOG4105KCK	Peptidoglycan-associated lipoprotein
GCD22_03737	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
GCD22_03739	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
GCD22_03741	ENOG4105M8F	Biopolymer transport protein exbD tolR
GCD22_03742	ENOG4105E02	MotA TolQ exbB proton channel
GCD22_03743	ENOG4107YD3	Thioesterase
GCD22_03744	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
GCD22_03745	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
GCD22_03746	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
GCD22_03749	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
GCD22_03750	ENOG4108TIT	dATP pyrophosphohydrolase
GCD22_03751	ENOG4105C9M	aspartyl-trna synthetase
GCD22_03753	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
GCD22_03761	ENOG4107QNK	)-transporter
GCD22_03762	ENOG4108IJ9	(ABC) transporter
GCD22_03767	ENOG4105CNN	ABC, transporter
GCD22_03768	ENOG4105C2J	ABC transporter
GCD22_03769	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
GCD22_03770	ENOG4108RVA	ribokinase
GCD22_03773	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
GCD22_03774	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
GCD22_03775	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
GCD22_03776	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
GCD22_03777	ENOG4105CMT	Dihydroxyacetone kinase
GCD22_03778	ENOG4108UTZ	Dihydroxyacetone kinase
GCD22_03779	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
GCD22_03783	ENOG4105C5H	ABC transporter
GCD22_03786	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
GCD22_03787	ENOG4107QTH	restriction modification system DNA specificity domain
GCD22_03788	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
GCD22_03790	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
GCD22_03792	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
GCD22_03793	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
GCD22_03794	ENOG4105MYT	Heat shock protein
GCD22_03795	ENOG4105D1S	lipid A biosynthesis
GCD22_03796	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
GCD22_03798	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
GCD22_03802	ENOG4105C03	ribonuclease
GCD22_03803	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
GCD22_03805	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
GCD22_03806	ENOG4107S5G	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
GCD22_03807	ENOG4105DWF	phosphomethylpyrimidine kinase