locus-tag	class	description
GCD22_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GCD22_00002	COG0592	DNA-directed DNA polymerase activity
GCD22_00003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GCD22_00004	COG0187	DNA topoisomerase II activity
GCD22_00006	COG0543	2 iron, 2 sulfur cluster binding
GCD22_00006	COG0493	'glutamate synthase
GCD22_00008	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GCD22_00010	COG0850	regulation of cytokinetic process
GCD22_00011	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GCD22_00013	COG2922	Belongs to the Smg family
GCD22_00014	COG0758	DNA mediated transformation
GCD22_00016	COG0242	peptide deformylase activity
GCD22_00017	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GCD22_00018	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GCD22_00018	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GCD22_00020	COG5000	phosphorelay sensor kinase activity
GCD22_00021	COG2204	response regulator
GCD22_00024	COG0277	FAD linked oxidase domain protein
GCD22_00025	COG0277	FAD linked oxidase domain protein
GCD22_00026	COG0247	lactate metabolic process
GCD22_00031	COG0521	Mo-molybdopterin cofactor biosynthetic process
GCD22_00035	COG4804	nuclease activity
GCD22_00041	COG0445	tRNA wobble uridine modification
GCD22_00042	COG0357	Ribosomal RNA small subunit methyltransferase G
GCD22_00043	COG1192	Involved in chromosome partitioning
GCD22_00046	COG0356	it plays a direct role in the translocation of protons across the membrane
GCD22_00048	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GCD22_00049	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GCD22_00050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GCD22_00051	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GCD22_00054	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GCD22_00057	COG2378	regulation of single-species biofilm formation
GCD22_00072	COG0789	Transcriptional regulator
GCD22_00076	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCD22_00076	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCD22_00078	COG0477	Major facilitator Superfamily
GCD22_00082	COG3220	belongs to the UPF0276 family
GCD22_00086	COG4232	protein-disulfide reductase activity
GCD22_00103	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCD22_00108	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GCD22_00111	COG0210	DNA helicase
GCD22_00113	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GCD22_00115	COG1611	Belongs to the LOG family
GCD22_00117	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GCD22_00118	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GCD22_00120	COG1333	cytochrome c biogenesis protein
GCD22_00121	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GCD22_00123	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GCD22_00132	COG2081	HI0933 family
GCD22_00134	COG0778	Nitroreductase
GCD22_00136	COG2814	Major facilitator Superfamily
GCD22_00138	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_00139	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_00140	COG0649	NAD binding
GCD22_00140	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_00143	COG1034	ATP synthesis coupled electron transport
GCD22_00143	COG1034	ATP synthesis coupled electron transport
GCD22_00144	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GCD22_00148	COG0713	ATP synthesis coupled electron transport
GCD22_00149	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCD22_00152	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GCD22_00153	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GCD22_00154	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GCD22_00155	COG3300	MHYT domain
GCD22_00155	COG5001	Diguanylate cyclase
GCD22_00163	COG2885	chlorophyll binding
GCD22_00164	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GCD22_00165	COG0508	dehydrogenase complex catalyzes the overall conversion of
GCD22_00165	COG0022	dehydrogenase e1 component
GCD22_00168	COG0316	Belongs to the HesB IscA family
GCD22_00171	COG0189	ligase activity
GCD22_00174	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GCD22_00175	COG0540	Belongs to the ATCase OTCase family
GCD22_00182	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GCD22_00184	COG0140	phosphoribosyl-ATP diphosphatase activity
GCD22_00184	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GCD22_00185	COG0107	imidazoleglycerol-phosphate synthase activity
GCD22_00186	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GCD22_00187	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GCD22_00188	COG0131	Imidazoleglycerol-phosphate dehydratase
GCD22_00189	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GCD22_00190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GCD22_00191	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GCD22_00192	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GCD22_00193	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GCD22_00195	COG0842	Transport permease protein
GCD22_00196	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GCD22_00197	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GCD22_00199	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GCD22_00203	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GCD22_00205	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GCD22_00209	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCD22_00209	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GCD22_00209	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GCD22_00210	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GCD22_00214	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GCD22_00216	COG1194	a g-specific adenine glycosylase
GCD22_00222	COG2205	protein histidine kinase activity
GCD22_00224	COG2204	response regulator
GCD22_00225	COG0076	glutamate decarboxylase activity
GCD22_00226	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCD22_00227	COG2062	phosphohistidine phosphatase, SixA
GCD22_00228	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GCD22_00229	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GCD22_00230	COG1127	ABC transporter
GCD22_00231	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GCD22_00232	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GCD22_00235	COG1131	(ABC) transporter
GCD22_00237	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GCD22_00239	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GCD22_00242	COG0018	arginyl-trna synthetase
GCD22_00243	COG2814	Major facilitator Superfamily
GCD22_00244	COG0583	DNA-binding transcription factor activity
GCD22_00245	COG2890	protein-(glutamine-N5) methyltransferase activity
GCD22_00246	COG0708	Exodeoxyribonuclease III
GCD22_00248	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GCD22_00249	COG0625	glutathione transferase activity
GCD22_00250	COG0708	Exodeoxyribonuclease III
GCD22_00251	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GCD22_00252	COG1047	Peptidyl-prolyl cis-trans
GCD22_00253	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GCD22_00254	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GCD22_00255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GCD22_00260	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GCD22_00261	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GCD22_00272	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GCD22_00283	COG1196	nuclear chromosome segregation
GCD22_00283	COG0741	lytic transglycosylase activity
GCD22_00283	COG0739	heme binding
GCD22_00286	COG2264	protein methyltransferase activity
GCD22_00287	COG0439	Biotin carboxylase
GCD22_00288	COG0511	ligase activity, forming carbon-carbon bonds
GCD22_00289	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GCD22_00292	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GCD22_00295	COG1181	Belongs to the D-alanine--D-alanine ligase family
GCD22_00296	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GCD22_00297	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GCD22_00298	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GCD22_00299	COG0772	Belongs to the SEDS family
GCD22_00300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GCD22_00301	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GCD22_00302	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GCD22_00306	COG0275	rRNA processing
GCD22_00307	COG2001	Belongs to the MraZ family
GCD22_00311	COG0625	glutathione transferase activity
GCD22_00312	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GCD22_00313	COG0653	protein targeting
GCD22_00314	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GCD22_00315	COG0494	nUDIX hydrolase
GCD22_00316	COG0463	Glycosyl transferase, family 2
GCD22_00318	COG0438	transferase activity, transferring glycosyl groups
GCD22_00325	COG1519	Transferase
GCD22_00326	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GCD22_00327	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GCD22_00328	COG3180	Ammonia monooxygenase
GCD22_00329	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GCD22_00330	COG1040	competence protein
GCD22_00331	COG0156	8-amino-7-oxononanoate synthase activity
GCD22_00332	COG0596	Alpha beta hydrolase
GCD22_00333	COG2226	methyltransferase
GCD22_00334	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GCD22_00335	COG0501	Belongs to the peptidase M48B family
GCD22_00336	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GCD22_00337	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GCD22_00338	COG0390	transport system, permease component
GCD22_00339	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GCD22_00344	COG1309	transcriptional regulator
GCD22_00345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GCD22_00347	COG1566	PFAM secretion protein HlyD family protein
GCD22_00349	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GCD22_00358	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GCD22_00359	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GCD22_00360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GCD22_00361	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GCD22_00363	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GCD22_00368	COG0735	belongs to the Fur family
GCD22_00369	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GCD22_00370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GCD22_00371	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GCD22_00372	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GCD22_00375	COG0659	secondary active sulfate transmembrane transporter activity
GCD22_00376	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GCD22_00377	COG2226	methyltransferase
GCD22_00379	COG2813	Specifically methylates the guanine in position
GCD22_00379	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GCD22_00380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GCD22_00382	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GCD22_00383	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GCD22_00384	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GCD22_00384	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GCD22_00387	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GCD22_00388	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GCD22_00391	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GCD22_00396	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GCD22_00400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GCD22_00401	COG0081	regulation of translation
GCD22_00402	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GCD22_00403	COG0222	ribosome binding
GCD22_00404	COG0085	RNA polymerase activity
GCD22_00405	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GCD22_00406	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GCD22_00407	COG0049	tRNA binding
GCD22_00408	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GCD22_00409	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GCD22_00410	COG0051	transcription antitermination factor activity, RNA binding
GCD22_00411	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GCD22_00412	COG0088	Forms part of the polypeptide exit tunnel
GCD22_00413	COG0089	rRNA binding
GCD22_00414	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GCD22_00415	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GCD22_00416	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GCD22_00418	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GCD22_00419	COG0255	Belongs to the universal ribosomal protein uL29 family
GCD22_00420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GCD22_00421	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GCD22_00422	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GCD22_00423	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GCD22_00424	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GCD22_00425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GCD22_00426	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GCD22_00427	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GCD22_00428	COG1841	ribosomal large subunit assembly
GCD22_00429	COG0200	Binds to the 23S rRNA
GCD22_00430	COG0201	protein transport
GCD22_00431	COG0563	adenylate kinase activity
GCD22_00432	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GCD22_00433	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GCD22_00434	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GCD22_00435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GCD22_00436	COG0202	RNA polymerase activity
GCD22_00437	COG0203	ribosomal protein L17
GCD22_00439	COG0756	dUTP diphosphatase activity
GCD22_00440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GCD22_00441	COG2003	Belongs to the UPF0758 family
GCD22_00450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GCD22_00450	COG0678	peroxiredoxin activity
GCD22_00452	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GCD22_00454	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GCD22_00455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GCD22_00456	COG0585	pseudouridine synthase activity
GCD22_00458	COG2608	mercury ion transmembrane transporter activity
GCD22_00460	COG0492	ferredoxin-NADP+ reductase activity
GCD22_00461	COG0431	NADPH-dependent FMN reductase
GCD22_00464	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GCD22_00466	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GCD22_00467	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GCD22_00469	COG1376	ErfK ybiS ycfS ynhG family protein
GCD22_00476	COG0779	Required for maturation of 30S ribosomal subunits
GCD22_00477	COG0195	Participates in both transcription termination and antitermination
GCD22_00478	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GCD22_00479	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GCD22_00480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GCD22_00481	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GCD22_00482	COG1185	polyribonucleotide nucleotidyltransferase activity
GCD22_00484	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCD22_00485	COG2226	methyltransferase
GCD22_00486	COG0328	RNA-DNA hybrid ribonuclease activity
GCD22_00487	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GCD22_00488	COG0346	lactoylglutathione lyase activity
GCD22_00489	COG0137	argininosuccinate synthase activity
GCD22_00490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GCD22_00491	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GCD22_00494	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GCD22_00496	COG1388	LysM domain
GCD22_00496	COG0741	lytic transglycosylase activity
GCD22_00514	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCD22_00516	COG0538	isocitrate dehydrogenase activity
GCD22_00517	COG0045	succinate-CoA ligase (ADP-forming) activity
GCD22_00519	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GCD22_00520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GCD22_00520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GCD22_00521	COG0347	Belongs to the P(II) protein family
GCD22_00527	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GCD22_00528	COG0235	Class ii aldolase
GCD22_00530	COG0242	peptide deformylase activity
GCD22_00532	COG1088	dTDP-glucose 4,6-dehydratase activity
GCD22_00537	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GCD22_00538	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GCD22_00540	COG2204	response regulator
GCD22_00542	COG2205	protein histidine kinase activity
GCD22_00543	COG0497	DNA recombination
GCD22_00544	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GCD22_00545	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GCD22_00547	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GCD22_00548	COG1466	dna polymerase III delta subunit
GCD22_00550	COG0495	leucyl-tRNA aminoacylation
GCD22_00551	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GCD22_00554	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GCD22_00560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCD22_00561	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCD22_00561	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GCD22_00562	COG0312	modulator of DNA gyrase
GCD22_00563	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GCD22_00564	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GCD22_00565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GCD22_00566	COG0149	triose-phosphate isomerase activity
GCD22_00567	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GCD22_00569	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_00570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_00571	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_00572	COG0649	NAD binding
GCD22_00573	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GCD22_00575	COG1034	ATP synthesis coupled electron transport
GCD22_00576	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GCD22_00577	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCD22_00579	COG0713	ATP synthesis coupled electron transport
GCD22_00582	COG1007	ATP synthesis coupled electron transport
GCD22_00585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GCD22_00586	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GCD22_00587	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GCD22_00588	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GCD22_00589	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GCD22_00590	COG0072	phenylalanine-tRNA ligase activity
GCD22_00591	COG0776	regulation of translation
GCD22_00617	COG3311	Transcriptional regulator
GCD22_00633	COG4962	Type ii secretion system protein e
GCD22_00634	COG1598	PFAM Uncharacterised protein family UPF0150
GCD22_00638	COG3451	type IV secretory pathway VirB4
GCD22_00650	COG3701	Conjugal transfer protein
GCD22_00660	COG0328	RNA-DNA hybrid ribonuclease activity
GCD22_00673	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCD22_00674	COG0583	DNA-binding transcription factor activity
GCD22_00676	COG0418	dihydroorotase activity
GCD22_00682	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCD22_00683	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCD22_00688	COG1475	DNA binding
GCD22_00698	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GCD22_00706	COG4115	mRNA cleavage
GCD22_00708	COG4953	penicillin-binding protein 1C
GCD22_00716	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GCD22_00717	COG0531	amino acid
GCD22_00754	COG1278	Cold shock
GCD22_00755	COG2204	response regulator
GCD22_00756	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GCD22_00757	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GCD22_00758	COG3161	chorismate lyase activity
GCD22_00759	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GCD22_00761	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GCD22_00762	COG1702	phosphate starvation-inducible protein PhoH
GCD22_00764	COG4535	Mg2 and Co2 transporter CorC
GCD22_00765	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GCD22_00766	COG0312	modulator of DNA gyrase
GCD22_00772	COG0523	cobalamin synthesis protein
GCD22_00782	COG1121	(ABC) transporter
GCD22_00791	COG2226	methyltransferase
GCD22_00792	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GCD22_00794	COG0066	3-isopropylmalate dehydratase activity
GCD22_00796	COG0259	pyridoxamine-phosphate oxidase activity
GCD22_00797	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GCD22_00799	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GCD22_00800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GCD22_00804	COG0109	protoheme IX farnesyltransferase activity
GCD22_00805	COG2814	Major facilitator Superfamily
GCD22_00806	COG1968	undecaprenyl-diphosphatase activity
GCD22_00807	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GCD22_00809	COG0505	Belongs to the CarA family
GCD22_00812	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GCD22_00824	COG1187	pseudouridine synthase activity
GCD22_00826	COG0494	nUDIX hydrolase
GCD22_00827	COG0012	GTP binding
GCD22_00828	COG0193	aminoacyl-tRNA hydrolase activity
GCD22_00829	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GCD22_00830	COG0768	penicillin binding
GCD22_00834	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GCD22_00837	COG1335	isochorismatase
GCD22_00842	COG0589	response to stress
GCD22_00843	COG0442	prolyl-tRNA aminoacylation
GCD22_00852	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GCD22_00861	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GCD22_00862	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GCD22_00863	COG3852	Histidine kinase
GCD22_00864	COG2204	response regulator
GCD22_00867	COG1562	ergosterol biosynthetic process
GCD22_00868	COG1657	PFAM Prenyltransferase squalene oxidase
GCD22_00869	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GCD22_00870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCD22_00877	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GCD22_00880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GCD22_00881	COG0154	amidase activity
GCD22_00882	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GCD22_00887	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GCD22_00888	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GCD22_00889	COG1845	cytochrome c oxidase, subunit III
GCD22_00892	COG0109	protoheme IX farnesyltransferase activity
GCD22_00897	COG0737	Belongs to the 5'-nucleotidase family
GCD22_00899	COG1333	cytochrome c biogenesis protein
GCD22_00901	COG3258	Cytochrome c
GCD22_00902	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GCD22_00907	COG0529	Catalyzes the synthesis of activated sulfate
GCD22_00907	COG2046	Belongs to the sulfate adenylyltransferase family
GCD22_00908	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GCD22_00912	COG4942	peptidase
GCD22_00931	COG2273	Hydrolase Family 16
GCD22_00940	COG2161	toxin-antitoxin pair type II binding
GCD22_00941	COG4115	mRNA cleavage
GCD22_00944	COG1002	Type II restriction enzyme, methylase subunits
GCD22_00946	COG1061	Type III restriction enzyme res subunit
GCD22_00947	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GCD22_00957	COG0582	viral genome integration into host DNA
GCD22_00961	COG1686	Belongs to the peptidase S11 family
GCD22_00962	COG2814	Major facilitator Superfamily
GCD22_00969	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GCD22_00970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GCD22_00972	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GCD22_00974	COG1193	negative regulation of DNA recombination
GCD22_00975	COG0358	DNA primase activity
GCD22_00978	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GCD22_00980	COG0308	aminopeptidase N
GCD22_00985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GCD22_00988	COG1538	Outer membrane efflux protein
GCD22_00991	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GCD22_00992	COG1923	regulation of RNA biosynthetic process
GCD22_00993	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GCD22_00994	COG0330	HflC and HflK could
GCD22_00996	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GCD22_01003	COG2995	paraquat-inducible protein a
GCD22_01007	COG0616	signal peptide processing
GCD22_01008	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GCD22_01009	COG0314	molybdopterin synthase activity
GCD22_01011	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GCD22_01013	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCD22_01014	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCD22_01015	COG0714	Associated with various cellular activities
GCD22_01018	COG1132	(ABC) transporter
GCD22_01019	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GCD22_01020	COG0450	alkyl hydroperoxide reductase
GCD22_01023	COG0628	permease
GCD22_01026	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GCD22_01027	COG0084	hydrolase, TatD family'
GCD22_01028	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GCD22_01028	COG0321	lipoyl(octanoyl) transferase activity
GCD22_01031	COG4988	ABC transporter
GCD22_01032	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GCD22_01035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GCD22_01039	COG0481	GTPase activity
GCD22_01040	COG0681	Belongs to the peptidase S26 family
GCD22_01044	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GCD22_01045	COG1381	Involved in DNA repair and RecF pathway recombination
GCD22_01046	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GCD22_01047	COG0736	holo-[acyl-carrier-protein] synthase activity
GCD22_01049	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GCD22_01050	COG0037	tRNA processing
GCD22_01051	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GCD22_01058	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GCD22_01059	COG0416	fatty acid biosynthetic process
GCD22_01060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GCD22_01061	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GCD22_01063	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GCD22_01064	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GCD22_01066	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GCD22_01075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GCD22_01077	COG0071	Belongs to the small heat shock protein (HSP20) family
GCD22_01091	COG3038	cytochrome b561
GCD22_01095	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GCD22_01105	COG1566	PFAM secretion protein HlyD family protein
GCD22_01106	COG1538	Outer membrane efflux protein
GCD22_01108	COG2814	Major facilitator Superfamily
GCD22_01114	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GCD22_01116	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GCD22_01116	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GCD22_01117	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GCD22_01119	COG0802	atpase or kinase
GCD22_01120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GCD22_01121	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GCD22_01123	COG1289	transmembrane transporter activity
GCD22_01125	COG1566	PFAM secretion protein HlyD family protein
GCD22_01126	COG0105	UTP biosynthetic process
GCD22_01127	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GCD22_01128	COG0457	Tetratricopeptide repeat
GCD22_01130	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GCD22_01131	COG0124	histidyl-tRNA synthetase
GCD22_01134	COG1160	GTP binding
GCD22_01145	COG0418	dihydroorotase activity
GCD22_01151	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GCD22_01155	COG1193	negative regulation of DNA recombination
GCD22_01156	COG0277	FAD linked oxidase domain protein
GCD22_01157	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GCD22_01158	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GCD22_01161	COG0617	tRNA 3'-terminal CCA addition
GCD22_01162	COG0617	tRNA 3'-terminal CCA addition
GCD22_01168	COG0519	Catalyzes the synthesis of GMP from XMP
GCD22_01168	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GCD22_01170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GCD22_01175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GCD22_01176	COG0009	L-threonylcarbamoyladenylate synthase
GCD22_01177	COG1994	Peptidase M50
GCD22_01178	COG0180	Tryptophanyl-tRNA synthetase
GCD22_01179	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GCD22_01180	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GCD22_01182	COG1187	pseudouridine synthase activity
GCD22_01185	COG5278	phosphoserine phosphatase activity
GCD22_01185	COG0840	transmembrane signaling receptor activity
GCD22_01186	COG0784	Response regulator, receiver
GCD22_01186	COG0835	chemotaxis
GCD22_01187	COG0840	transmembrane signaling receptor activity
GCD22_01191	COG0643	Histidine kinase
GCD22_01191	COG2198	Histidine kinase
GCD22_01194	COG1360	Flagellar Motor Protein
GCD22_01196	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GCD22_01197	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GCD22_01201	COG1815	bacterial-type flagellum-dependent cell motility
GCD22_01202	COG1558	bacterial-type flagellum-dependent cell motility
GCD22_01203	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GCD22_01204	COG1749	Flagellar hook protein flgE
GCD22_01206	COG4786	Flagellar basal body rod
GCD22_01207	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GCD22_01208	COG1706	bacterial-type flagellum-dependent cell motility
GCD22_01209	COG1705	Flagellar rod assembly protein muramidase FlgJ
GCD22_01209	COG3951	Flagellar rod assembly protein muramidase FlgJ
GCD22_01211	COG1256	bacterial-type flagellum assembly
GCD22_01217	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GCD22_01221	COG1516	flagellar protein fliS
GCD22_01224	COG3852	Histidine kinase
GCD22_01226	COG1677	Flagellar hook-basal body complex protein FliE
GCD22_01228	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GCD22_01235	COG3190	flagellar
GCD22_01237	COG1987	bacterial-type flagellum assembly
GCD22_01242	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GCD22_01244	COG0455	bacterial-type flagellum organization
GCD22_01245	COG1191	sigma factor activity
GCD22_01246	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GCD22_01248	COG3706	GGDEF domain
GCD22_01250	COG3706	GGDEF domain
GCD22_01253	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GCD22_01255	COG3706	GGDEF domain
GCD22_01255	COG0745	RESPONSE REGULATOR receiver
GCD22_01257	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GCD22_01258	COG2201	protein-glutamate methylesterase activity
GCD22_01262	COG2257	FlhB HrpN YscU SpaS Family
GCD22_01265	COG2915	High frequency lysogenization protein hflD homolog
GCD22_01266	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GCD22_01267	COG0024	Methionine aminopeptidase
GCD22_01268	COG1489	DNA binding
GCD22_01269	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCD22_01271	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GCD22_01273	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GCD22_01274	COG2137	regulation of response to DNA damage stimulus
GCD22_01287	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GCD22_01290	COG0488	(ABC) transporter
GCD22_01291	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GCD22_01294	COG1271	oxidase subunit
GCD22_01307	COG2363	Small membrane protein
GCD22_01309	COG0477	Major facilitator Superfamily
GCD22_01310	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GCD22_01311	COG0574	Belongs to the PEP-utilizing enzyme family
GCD22_01311	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GCD22_01314	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GCD22_01315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GCD22_01318	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GCD22_01321	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GCD22_01321	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GCD22_01322	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GCD22_01323	COG3454	Phosphonate metabolism
GCD22_01324	COG4778	phosphonate C-P lyase system protein PhnL
GCD22_01325	COG4107	phosphonate C-P lyase system protein PhnK
GCD22_01326	COG3627	carbon phosphorus lyase activity
GCD22_01327	COG3626	phosphonate metabolism
GCD22_01328	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
GCD22_01330	COG2271	Major facilitator Superfamily
GCD22_01347	COG1070	Carbohydrate kinase
GCD22_01348	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GCD22_01349	COG1196	nuclear chromosome segregation
GCD22_01352	COG1266	CAAX protease self-immunity
GCD22_01353	COG1131	(ABC) transporter
GCD22_01355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GCD22_01356	COG2885	chlorophyll binding
GCD22_01358	COG0477	Major facilitator Superfamily
GCD22_01359	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GCD22_01361	COG1598	PFAM Uncharacterised protein family UPF0150
GCD22_01363	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GCD22_01364	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GCD22_01365	COG1166	arginine decarboxylase activity
GCD22_01375	COG0438	transferase activity, transferring glycosyl groups
GCD22_01379	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GCD22_01383	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GCD22_01384	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCD22_01386	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GCD22_01387	COG1570	exodeoxyribonuclease VII activity
GCD22_01388	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GCD22_01392	COG2223	nitrite transmembrane transporter activity
GCD22_01393	COG1722	exodeoxyribonuclease VII activity
GCD22_01394	COG0142	geranyltranstransferase activity
GCD22_01395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GCD22_01396	COG1469	GTP cyclohydrolase I activity
GCD22_01397	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GCD22_01400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GCD22_01402	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCD22_01412	COG0729	surface antigen
GCD22_01418	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GCD22_01419	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCD22_01421	COG3220	belongs to the UPF0276 family
GCD22_01425	COG4232	protein-disulfide reductase activity
GCD22_01428	COG2814	Major facilitator Superfamily
GCD22_01430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCD22_01430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCD22_01434	COG2226	methyltransferase
GCD22_01440	COG0393	Putative heavy-metal-binding
GCD22_01461	COG2995	paraquat-inducible protein a
GCD22_01468	COG1271	oxidase subunit
GCD22_01473	COG0509	glycine decarboxylation via glycine cleavage system
GCD22_01474	COG0038	chloride channel
GCD22_01480	COG0583	DNA-binding transcription factor activity
GCD22_01482	COG0583	DNA-binding transcription factor activity
GCD22_01488	COG3302	dmso reductase anchor subunit
GCD22_01489	COG0437	4 iron, 4 sulfur cluster binding
GCD22_01490	COG0243	molybdopterin cofactor binding
GCD22_01501	COG2718	Belongs to the UPF0229 family
GCD22_01510	COG0675	Transposase, IS605 OrfB family
GCD22_01553	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GCD22_01554	COG1140	nitrate reductase beta subunit
GCD22_01556	COG2181	nitrate reductase activity
GCD22_01565	COG0509	glycine decarboxylation via glycine cleavage system
GCD22_01567	COG3189	MarR family transcriptional regulator
GCD22_01573	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GCD22_01579	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GCD22_01580	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GCD22_01583	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GCD22_01590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GCD22_01592	COG0583	DNA-binding transcription factor activity
GCD22_01594	COG0166	Belongs to the GPI family
GCD22_01597	COG0675	Transposase, IS605 OrfB family
GCD22_01598	COG0675	Transposase, IS605 OrfB family
GCD22_01628	COG4581	dead DEAH box helicase
GCD22_01656	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GCD22_01657	COG1278	Cold shock
GCD22_01694	COG2200	EAL domain
GCD22_01694	COG2199	diguanylate cyclase activity
GCD22_01697	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GCD22_01707	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GCD22_01713	COG2226	methyltransferase
GCD22_01717	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCD22_01717	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCD22_01719	COG2814	Major facilitator Superfamily
GCD22_01722	COG4232	protein-disulfide reductase activity
GCD22_01726	COG3220	belongs to the UPF0276 family
GCD22_01729	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCD22_01730	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GCD22_01731	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GCD22_01758	COG2827	Endonuclease containing a URI domain
GCD22_01763	COG2814	Major facilitator Superfamily
GCD22_01765	COG2079	MmgE PrpD family protein
GCD22_01767	COG0583	DNA-binding transcription factor activity
GCD22_01768	COG2197	response regulator
GCD22_01770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GCD22_01782	COG0210	DNA helicase
GCD22_01791	COG2204	response regulator
GCD22_01801	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GCD22_01804	COG0298	carbon dioxide binding
GCD22_01805	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GCD22_01808	COG0375	protein maturation
GCD22_01809	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GCD22_01825	COG0675	Transposase, IS605 OrfB family
GCD22_01858	COG0776	regulation of translation
GCD22_01879	COG3451	type IV secretory pathway VirB4
GCD22_01890	COG2948	multi-organism process
GCD22_01893	COG4964	Belongs to the GSP D family
GCD22_01896	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GCD22_01902	COG0210	DNA helicase
GCD22_01906	COG0629	single-stranded DNA binding
GCD22_01910	COG0675	Transposase, IS605 OrfB family
GCD22_01948	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCD22_01954	COG1475	DNA binding
GCD22_01973	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GCD22_01973	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCD22_02000	COG0583	DNA-binding transcription factor activity
GCD22_02001	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCD22_02011	COG0789	Transcriptional regulator
GCD22_02019	COG0574	Belongs to the PEP-utilizing enzyme family
GCD22_02019	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GCD22_02021	COG0730	response to heat
GCD22_02029	COG2814	Major facilitator Superfamily
GCD22_02034	COG1028	Short-chain dehydrogenase reductase Sdr
GCD22_02047	COG3550	peptidyl-serine autophosphorylation
GCD22_02048	COG4453	Protein conserved in bacteria
GCD22_02055	COG0842	Transport permease protein
GCD22_02056	COG0842	Transport permease protein
GCD22_02057	COG1131	(ABC) transporter
GCD22_02059	COG1538	Outer membrane efflux protein
GCD22_02062	COG1595	DNA-templated transcription, initiation
GCD22_02066	COG1294	oxidase, subunit
GCD22_02067	COG1271	oxidase subunit
GCD22_02074	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GCD22_02075	COG0022	dehydrogenase e1 component
GCD22_02076	COG0508	dehydrogenase complex catalyzes the overall conversion of
GCD22_02077	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GCD22_02078	COG0280	phosphate acetyltransferase
GCD22_02079	COG1105	Belongs to the carbohydrate kinase PfkB family
GCD22_02082	COG0148	phosphopyruvate hydratase activity
GCD22_02084	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GCD22_02085	COG2814	Major facilitator Superfamily
GCD22_02088	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GCD22_02091	COG1271	oxidase subunit
GCD22_02098	COG3306	glycosyltransferase involved in LPS biosynthesis
GCD22_02103	COG3706	GGDEF domain
GCD22_02112	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GCD22_02113	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GCD22_02115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GCD22_02116	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GCD22_02117	COG0037	tRNA processing
GCD22_02118	COG0825	malonyl-CoA metabolic process
GCD22_02120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GCD22_02125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GCD22_02126	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCD22_02130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GCD22_02131	COG0575	Belongs to the CDS family
GCD22_02132	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GCD22_02134	COG0528	UMP kinase activity
GCD22_02135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GCD22_02136	COG0052	Belongs to the universal ribosomal protein uS2 family
GCD22_02139	COG0704	Plays a role in the regulation of phosphate uptake
GCD22_02140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GCD22_02141	COG5002	protein histidine kinase activity
GCD22_02143	COG0513	Belongs to the DEAD box helicase family
GCD22_02144	COG0667	Aldo Keto reductase
GCD22_02145	COG0482	sulfurtransferase activity
GCD22_02148	COG0443	Heat shock 70 kDa protein
GCD22_02149	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GCD22_02151	COG0822	iron-sulfur transferase activity
GCD22_02152	COG1104	cysteine desulfurase activity
GCD22_02153	COG1959	2 iron, 2 sulfur cluster binding
GCD22_02154	COG1045	serine acetyltransferase
GCD22_02159	COG2350	Protein conserved in bacteria
GCD22_02161	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GCD22_02161	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GCD22_02163	COG0129	dihydroxy-acid dehydratase activity
GCD22_02164	COG0628	permease
GCD22_02165	COG0281	malic enzyme
GCD22_02166	COG0254	rRNA binding
GCD22_02177	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GCD22_02181	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GCD22_02182	COG1127	ABC transporter
GCD22_02183	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GCD22_02185	COG2022	thiamine diphosphate biosynthetic process
GCD22_02189	COG4636	protein conserved in cyanobacteria
GCD22_02195	COG2226	methyltransferase
GCD22_02201	COG0640	Transcriptional regulator
GCD22_02205	COG0210	DNA helicase
GCD22_02207	COG0268	Binds directly to 16S ribosomal RNA
GCD22_02211	COG3842	ATPase activity
GCD22_02214	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GCD22_02215	COG0514	ATP-dependent DNA helicase (RecQ)
GCD22_02216	COG1965	Belongs to the frataxin family
GCD22_02221	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GCD22_02223	COG0795	lipopolysaccharide-transporting ATPase activity
GCD22_02224	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GCD22_02227	COG0525	valine-tRNA ligase activity
GCD22_02228	COG0525	valine-tRNA ligase activity
GCD22_02229	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GCD22_02234	COG1902	pentaerythritol trinitrate reductase activity
GCD22_02246	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GCD22_02255	COG3220	belongs to the UPF0276 family
GCD22_02257	COG4232	protein-disulfide reductase activity
GCD22_02260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCD22_02266	COG2210	Belongs to the sulfur carrier protein TusA family
GCD22_02267	COG0425	Belongs to the sulfur carrier protein TusA family
GCD22_02272	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCD22_02275	COG0776	regulation of translation
GCD22_02276	COG0776	regulation of translation
GCD22_02280	COG5001	Diguanylate cyclase
GCD22_02280	COG5002	protein histidine kinase activity
GCD22_02280	COG3447	MASE1 domain protein
GCD22_02282	COG3300	MHYT domain
GCD22_02282	COG5001	Diguanylate cyclase
GCD22_02291	COG0697	spore germination
GCD22_02293	COG0546	phosphoglycolate phosphatase activity
GCD22_02296	COG1530	ribonuclease E activity
GCD22_02297	COG0215	cysteine-tRNA ligase activity
GCD22_02298	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCD22_02300	COG0415	Belongs to the DNA photolyase family
GCD22_02312	COG0730	response to heat
GCD22_02314	COG0326	Molecular chaperone. Has ATPase activity
GCD22_02315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCD22_02317	COG0519	Catalyzes the synthesis of GMP from XMP
GCD22_02324	COG0628	permease
GCD22_02349	COG1271	oxidase subunit
GCD22_02350	COG1294	oxidase, subunit
GCD22_02353	COG3223	Belongs to the PsiE family
GCD22_02370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCD22_02378	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GCD22_02404	COG0791	NLP P60 protein
GCD22_02406	COG0402	S-adenosylhomocysteine deaminase activity
GCD22_02407	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GCD22_02412	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GCD22_02416	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GCD22_02419	COG0776	regulation of translation
GCD22_02420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GCD22_02421	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GCD22_02422	COG0740	serine-type endopeptidase activity
GCD22_02423	COG0544	peptidyl-prolyl cis-trans isomerase activity
GCD22_02424	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GCD22_02425	COG0284	orotidine-5'-phosphate decarboxylase activity
GCD22_02426	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GCD22_02427	COG0776	regulation of translation
GCD22_02429	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GCD22_02430	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GCD22_02431	COG0287	Prephenate dehydrogenase
GCD22_02432	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GCD22_02433	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GCD22_02435	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GCD22_02437	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GCD22_02438	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GCD22_02442	COG1475	DNA binding
GCD22_02443	COG1192	Involved in chromosome partitioning
GCD22_02444	COG2948	multi-organism process
GCD22_02457	COG3451	type IV secretory pathway VirB4
GCD22_02462	COG4962	Type ii secretion system protein e
GCD22_02480	COG0741	lytic transglycosylase activity
GCD22_02516	COG0393	Putative heavy-metal-binding
GCD22_02529	COG0629	single-stranded DNA binding
GCD22_02545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GCD22_02565	COG5377	YqaJ viral recombinase family
GCD22_02571	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GCD22_02572	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GCD22_02577	COG1487	ribonuclease activity
GCD22_02590	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GCD22_02593	COG2258	MOSC domain
GCD22_02597	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCD22_02600	COG3706	GGDEF domain
GCD22_02607	COG5377	YqaJ viral recombinase family
GCD22_02628	COG1132	(ABC) transporter
GCD22_02629	COG0676	glucose-6-phosphate 1-epimerase activity
GCD22_02631	COG2217	Heavy metal translocating P-type atpase
GCD22_02633	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GCD22_02635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GCD22_02636	COG0640	Transcriptional regulator
GCD22_02637	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GCD22_02642	COG0789	Transcriptional regulator
GCD22_02658	COG1271	oxidase subunit
GCD22_02663	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GCD22_02664	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GCD22_02669	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GCD22_02674	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GCD22_02675	COG1140	nitrate reductase beta subunit
GCD22_02676	COG2181	nitrate reductase activity
GCD22_02685	COG0509	glycine decarboxylation via glycine cleavage system
GCD22_02686	COG0038	chloride channel
GCD22_02687	COG1475	DNA binding
GCD22_02688	COG1192	Involved in chromosome partitioning
GCD22_02701	COG2226	methyltransferase
GCD22_02706	COG3220	belongs to the UPF0276 family
GCD22_02708	COG4232	protein-disulfide reductase activity
GCD22_02711	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCD22_02729	COG5001	Diguanylate cyclase
GCD22_02729	COG3300	MHYT domain
GCD22_02735	COG2814	Major facilitator Superfamily
GCD22_02736	COG0596	Alpha beta hydrolase
GCD22_02763	COG1538	Outer membrane efflux protein
GCD22_02764	COG2814	Major facilitator Superfamily
GCD22_02765	COG0038	chloride channel
GCD22_02767	COG0583	DNA-binding transcription factor activity
GCD22_02768	COG0628	permease
GCD22_02771	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GCD22_02774	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GCD22_02775	COG1758	RNA polymerase activity
GCD22_02777	COG1561	YicC-like family, N-terminal region
GCD22_02787	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCD22_02792	COG2193	ferroxidase activity
GCD22_02801	COG1850	ribulose-bisphosphate carboxylase activity
GCD22_02805	COG0196	riboflavin kinase activity
GCD22_02806	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GCD22_02807	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GCD22_02817	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GCD22_02821	COG4232	protein-disulfide reductase activity
GCD22_02823	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GCD22_02824	COG0459	protein refolding
GCD22_02831	COG1215	transferase activity, transferring glycosyl groups
GCD22_02834	COG5001	Diguanylate cyclase
GCD22_02834	COG3447	MASE1 domain protein
GCD22_02834	COG5002	protein histidine kinase activity
GCD22_02846	COG0582	viral genome integration into host DNA
GCD22_02864	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GCD22_02865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GCD22_02866	COG1862	Preprotein translocase
GCD22_02867	COG0343	queuine tRNA-ribosyltransferase activity
GCD22_02868	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GCD22_02869	COG1253	flavin adenine dinucleotide binding
GCD22_02872	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GCD22_02874	COG0285	dihydrofolate synthase activity
GCD22_02875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GCD22_02876	COG0159	tryptophan synthase activity
GCD22_02877	COG0133	tryptophan synthase activity
GCD22_02878	COG0135	phosphoribosylanthranilate isomerase activity
GCD22_02879	COG0101	tRNA pseudouridine synthase activity
GCD22_02881	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GCD22_02884	COG0746	molybdenum cofactor guanylyltransferase activity
GCD22_02885	COG1763	Mo-molybdopterin cofactor biosynthetic process
GCD22_02889	COG0500	methyltransferase
GCD22_02890	COG0583	DNA-binding transcription factor activity
GCD22_02891	COG0477	Major facilitator Superfamily
GCD22_02892	COG1538	Outer membrane efflux protein
GCD22_02893	COG1566	PFAM secretion protein HlyD family protein
GCD22_02898	COG0509	glycine decarboxylation via glycine cleavage system
GCD22_02900	COG3189	MarR family transcriptional regulator
GCD22_02904	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCD22_02916	COG0642	Histidine kinase
GCD22_02917	COG0745	RESPONSE REGULATOR receiver
GCD22_02924	COG2132	Multicopper oxidase
GCD22_02932	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCD22_02934	COG0531	amino acid
GCD22_02938	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GCD22_02939	COG0322	excinuclease ABC activity
GCD22_02941	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GCD22_02942	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GCD22_02943	COG0148	phosphopyruvate hydratase activity
GCD22_02944	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GCD22_02945	COG0504	CTP synthase activity
GCD22_02946	COG1064	alcohol dehydrogenase
GCD22_02949	COG0640	Transcriptional regulator
GCD22_02950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GCD22_02955	COG1183	phosphatidylcholine synthase activity
GCD22_02956	COG0688	phosphatidylethanolamine metabolic process
GCD22_02958	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GCD22_02960	COG0028	Belongs to the TPP enzyme family
GCD22_02961	COG1193	negative regulation of DNA recombination
GCD22_02963	COG0432	Pfam Uncharacterised protein family UPF0047
GCD22_02964	COG0590	tRNA wobble adenosine to inosine editing
GCD22_02970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GCD22_02971	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GCD22_02972	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GCD22_02974	COG0070	glutamate synthase
GCD22_02974	COG0069	glutamate synthase activity
GCD22_02974	COG0067	glutamate synthase
GCD22_02975	COG0493	'glutamate synthase
GCD22_02976	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GCD22_02982	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GCD22_02984	COG0438	transferase activity, transferring glycosyl groups
GCD22_02985	COG1216	Glycosyl transferase, family 2
GCD22_02987	COG0438	transferase activity, transferring glycosyl groups
GCD22_02996	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCD22_02997	COG0438	transferase activity, transferring glycosyl groups
GCD22_03000	COG0138	bifunctional purine biosynthesis protein purh
GCD22_03001	COG0151	Belongs to the GarS family
GCD22_03002	COG0009	L-threonylcarbamoyladenylate synthase
GCD22_03003	COG0408	coproporphyrinogen oxidase activity
GCD22_03004	COG0167	dihydroorotate dehydrogenase activity
GCD22_03006	COG2271	Major facilitator Superfamily
GCD22_03010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCD22_03011	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCD22_03021	COG0477	Major facilitator Superfamily
GCD22_03030	COG2205	protein histidine kinase activity
GCD22_03031	COG0745	RESPONSE REGULATOR receiver
GCD22_03033	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GCD22_03039	COG0033	Phosphoglucomutase
GCD22_03068	COG4974	Belongs to the 'phage' integrase family
GCD22_03070	COG0047	phosphoribosylformylglycinamidine synthase activity
GCD22_03070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GCD22_03071	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GCD22_03072	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GCD22_03074	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GCD22_03078	COG1272	protein, Hemolysin III
GCD22_03079	COG0860	N-Acetylmuramoyl-L-alanine amidase
GCD22_03081	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GCD22_03082	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCD22_03085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCD22_03088	COG0640	Transcriptional regulator
GCD22_03091	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GCD22_03094	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GCD22_03095	COG0084	hydrolase, TatD family'
GCD22_03096	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GCD22_03097	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GCD22_03105	COG1199	ATP-dependent helicase activity
GCD22_03107	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GCD22_03108	COG0791	NLP P60 protein
GCD22_03116	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GCD22_03117	COG0586	Pfam SNARE associated Golgi protein
GCD22_03124	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCD22_03124	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCD22_03140	COG0095	Lipoate-protein ligase
GCD22_03142	COG0509	glycine decarboxylation via glycine cleavage system
GCD22_03144	COG0509	glycine decarboxylation via glycine cleavage system
GCD22_03145	COG2048	Heterodisulfide reductase, subunit B
GCD22_03151	COG2210	Belongs to the sulfur carrier protein TusA family
GCD22_03152	COG0425	Belongs to the sulfur carrier protein TusA family
GCD22_03156	COG0437	4 iron, 4 sulfur cluster binding
GCD22_03157	COG0243	molybdopterin cofactor binding
GCD22_03159	COG0315	cyclic pyranopterin monophosphate synthase activity
GCD22_03161	COG3852	Histidine kinase
GCD22_03166	COG3258	Cytochrome c
GCD22_03167	COG3439	Domain of unknown function DUF302
GCD22_03168	COG0737	Belongs to the 5'-nucleotidase family
GCD22_03169	COG1077	Cell shape determining protein MreB Mrl
GCD22_03170	COG1792	Involved in formation and maintenance of cell shape
GCD22_03172	COG0772	Belongs to the SEDS family
GCD22_03173	COG1686	Belongs to the peptidase S11 family
GCD22_03175	COG0321	lipoyl(octanoyl) transferase activity
GCD22_03176	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GCD22_03186	COG0751	glycine-tRNA ligase activity
GCD22_03188	COG0204	Acyl-transferase
GCD22_03189	COG0189	ligase activity
GCD22_03196	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GCD22_03198	COG3023	N-Acetylmuramoyl-L-alanine amidase
GCD22_03201	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GCD22_03204	COG3604	Transcriptional regulator
GCD22_03216	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GCD22_03217	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GCD22_03218	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GCD22_03223	COG0058	SHG alpha-glucan phosphorylase activity
GCD22_03224	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GCD22_03226	COG0793	Belongs to the peptidase S41A family
GCD22_03227	COG0693	protein deglycase activity
GCD22_03230	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GCD22_03231	COG0542	response to heat
GCD22_03232	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GCD22_03233	COG0519	Catalyzes the synthesis of GMP from XMP
GCD22_03234	COG0450	alkyl hydroperoxide reductase
GCD22_03237	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GCD22_03238	COG2835	tetraacyldisaccharide 4'-kinase activity
GCD22_03239	COG1663	tetraacyldisaccharide 4'-kinase activity
GCD22_03242	COG0848	biopolymer transport protein
GCD22_03244	COG2333	competence protein COMEC
GCD22_03244	COG0658	competence protein
GCD22_03254	COG1742	UPF0060 membrane protein
GCD22_03256	COG3077	Addiction module antitoxin, RelB DinJ family
GCD22_03257	COG1136	(ABC) transporter
GCD22_03259	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GCD22_03260	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GCD22_03264	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GCD22_03266	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GCD22_03268	COG0436	Aminotransferase
GCD22_03270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GCD22_03271	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GCD22_03272	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GCD22_03275	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GCD22_03288	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GCD22_03291	COG3046	protein related to deoxyribodipyrimidine photolyase
GCD22_03295	COG0717	Belongs to the dCTP deaminase family
GCD22_03296	COG0489	protein tyrosine kinase activity
GCD22_03298	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GCD22_03299	COG0484	heat shock protein binding
GCD22_03300	COG0443	Heat shock 70 kDa protein
GCD22_03301	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GCD22_03302	COG1420	regulation of RNA biosynthetic process
GCD22_03304	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GCD22_03305	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GCD22_03307	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCD22_03307	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCD22_03308	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GCD22_03309	COG0114	fumarate hydratase activity
GCD22_03317	COG0297	glycogen (starch) synthase activity
GCD22_03319	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GCD22_03321	COG1376	ErfK ybiS ycfS ynhG family protein
GCD22_03325	COG0649	NAD binding
GCD22_03326	COG0651	ATP synthesis coupled electron transport
GCD22_03334	COG1850	ribulose-bisphosphate carboxylase activity
GCD22_03338	COG1872	DUF167
GCD22_03339	COG0659	secondary active sulfate transmembrane transporter activity
GCD22_03345	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GCD22_03347	COG2967	ApaG domain
GCD22_03348	COG2226	methyltransferase
GCD22_03357	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GCD22_03359	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GCD22_03362	COG2177	Part of the ABC transporter FtsEX involved in
GCD22_03363	COG2884	Cell division ATP-binding protein ftsE
GCD22_03364	COG0552	protein localization to endoplasmic reticulum
GCD22_03365	COG0742	ribosomal rna small subunit methyltransferase
GCD22_03366	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GCD22_03367	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GCD22_03368	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GCD22_03369	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GCD22_03370	COG2890	protein-(glutamine-N5) methyltransferase activity
GCD22_03371	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GCD22_03372	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GCD22_03375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GCD22_03377	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GCD22_03382	COG0393	Putative heavy-metal-binding
GCD22_03396	COG0006	proline dipeptidase activity
GCD22_03399	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GCD22_03400	COG0305	Participates in initiation and elongation during chromosome replication
GCD22_03401	COG0359	binds to the 23S rRNA
GCD22_03404	COG0360	Binds together with S18 to 16S ribosomal RNA
GCD22_03405	COG1472	Belongs to the glycosyl hydrolase 3 family
GCD22_03406	COG0531	amino acid
GCD22_03408	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCD22_03414	COG0363	glucosamine-6-phosphate deaminase activity
GCD22_03417	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GCD22_03418	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GCD22_03420	COG1449	Belongs to the glycosyl hydrolase 57 family
GCD22_03421	COG1940	carbohydrate kinase activity
GCD22_03425	COG2733	membrane
GCD22_03429	COG0629	single-stranded DNA binding
GCD22_03432	COG3118	belongs to the thioredoxin family
GCD22_03437	COG0335	large ribosomal subunit rRNA binding
GCD22_03438	COG0336	Belongs to the RNA methyltransferase TrmD family
GCD22_03439	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GCD22_03440	COG0228	four-way junction DNA binding
GCD22_03441	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GCD22_03446	COG3047	cAMP biosynthetic process
GCD22_03446	COG2885	chlorophyll binding
GCD22_03462	COG2944	sequence-specific DNA binding
GCD22_03464	COG1573	uracil-dna glycosylase
GCD22_03475	COG0142	geranyltranstransferase activity
GCD22_03478	COG3852	Histidine kinase
GCD22_03482	COG2308	Evidence 4 Homologs of previously reported genes of
GCD22_03486	COG2766	serine protein kinase
GCD22_03487	COG0004	ammonium transporteR
GCD22_03488	COG2718	Belongs to the UPF0229 family
GCD22_03489	COG2719	SpoVR family
GCD22_03491	COG0347	Belongs to the P(II) protein family
GCD22_03492	COG0004	ammonium transporteR
GCD22_03502	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GCD22_03504	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GCD22_03506	COG0768	penicillin binding
GCD22_03508	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GCD22_03509	COG1686	Belongs to the peptidase S11 family
GCD22_03510	COG0823	Involved in the tonB-independent uptake of proteins
GCD22_03516	COG0583	DNA-binding transcription factor activity
GCD22_03519	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GCD22_03520	COG1686	Belongs to the peptidase S11 family
GCD22_03521	COG0166	Belongs to the GPI family
GCD22_03522	COG1271	oxidase subunit
GCD22_03523	COG1294	oxidase, subunit
GCD22_03529	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GCD22_03534	COG0651	ATP synthesis coupled electron transport
GCD22_03536	COG3260	NADH ubiquinone oxidoreductase 20
GCD22_03537	COG0651	ATP synthesis coupled electron transport
GCD22_03538	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GCD22_03542	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GCD22_03545	COG0583	DNA-binding transcription factor activity
GCD22_03550	COG3220	belongs to the UPF0276 family
GCD22_03552	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GCD22_03553	COG1074	ATP-dependent DNA helicase activity
GCD22_03554	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCD22_03556	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GCD22_03557	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GCD22_03559	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCD22_03560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GCD22_03569	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GCD22_03570	COG0277	FAD linked oxidase domain protein
GCD22_03572	COG0859	PFAM glycosyl transferase family 9
GCD22_03575	COG0583	DNA-binding transcription factor activity
GCD22_03577	COG1393	Belongs to the ArsC family
GCD22_03581	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GCD22_03582	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GCD22_03583	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GCD22_03585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GCD22_03586	COG2833	Protein of unknown function (DUF455)
GCD22_03587	COG1271	oxidase subunit
GCD22_03588	COG1294	oxidase, subunit
GCD22_03595	COG0745	RESPONSE REGULATOR receiver
GCD22_03597	COG1914	H( )-stimulated, divalent metal cation uptake system
GCD22_03598	COG3842	ATPase activity
GCD22_03600	COG1178	ABC-type Fe3 transport system permease component
GCD22_03604	COG3145	DNA-N1-methyladenine dioxygenase activity
GCD22_03606	COG0583	DNA-binding transcription factor activity
GCD22_03610	COG2259	Doxx family
GCD22_03612	COG3384	dioxygenase
GCD22_03624	COG3657	addiction module killer protein
GCD22_03650	COG0019	diaminopimelate decarboxylase activity
GCD22_03652	COG0165	Argininosuccinate lyase
GCD22_03654	COG2205	protein histidine kinase activity
GCD22_03655	COG0745	RESPONSE REGULATOR receiver
GCD22_03658	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCD22_03659	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCD22_03661	COG1970	mechanosensitive ion channel activity
GCD22_03662	COG1322	Protein conserved in bacteria
GCD22_03663	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GCD22_03664	COG2326	polyphosphate kinase activity
GCD22_03665	COG2814	Major facilitator Superfamily
GCD22_03666	COG0598	Magnesium transport protein CorA
GCD22_03667	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GCD22_03669	COG1494	fructose-1,6-bisphosphatase
GCD22_03670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GCD22_03671	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GCD22_03672	COG0126	phosphoglycerate kinase activity
GCD22_03673	COG0469	pyruvate kinase activity
GCD22_03674	COG0191	fructose-bisphosphate aldolase activity
GCD22_03675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GCD22_03681	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GCD22_03682	COG0134	indole-3-glycerol-phosphate synthase activity
GCD22_03684	COG1959	2 iron, 2 sulfur cluster binding
GCD22_03685	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GCD22_03687	COG2945	thiolester hydrolase activity
GCD22_03688	COG1131	(ABC) transporter
GCD22_03696	COG0776	regulation of translation
GCD22_03699	COG0393	Putative heavy-metal-binding
GCD22_03702	COG0438	transferase activity, transferring glycosyl groups
GCD22_03702	COG1216	Glycosyl transferase, family 2
GCD22_03723	COG1278	Cold shock
GCD22_03724	COG2084	Dehydrogenase
GCD22_03725	COG0243	molybdopterin cofactor binding
GCD22_03727	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GCD22_03728	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GCD22_03729	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GCD22_03730	COG2271	Major facilitator Superfamily
GCD22_03732	COG0113	porphobilinogen synthase activity
GCD22_03734	COG0181	hydroxymethylbilane synthase activity
GCD22_03735	COG2885	chlorophyll binding
GCD22_03737	COG0602	queuosine metabolic process
GCD22_03739	COG0823	Involved in the tonB-independent uptake of proteins
GCD22_03743	COG0824	Thioesterase
GCD22_03744	COG2255	four-way junction helicase activity
GCD22_03745	COG0632	four-way junction helicase activity
GCD22_03746	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GCD22_03749	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GCD22_03750	COG0494	nUDIX hydrolase
GCD22_03751	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GCD22_03753	COG2095	MarC family integral membrane protein
GCD22_03761	COG2814	Major facilitator Superfamily
GCD22_03762	COG3842	ATPase activity
GCD22_03767	COG1172	Belongs to the binding-protein-dependent transport system permease family
GCD22_03769	COG1879	ABC-type sugar transport system periplasmic component
GCD22_03770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCD22_03775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GCD22_03777	COG2376	Dihydroxyacetone kinase
GCD22_03778	COG1461	Dihydroxyacetone kinase
GCD22_03783	COG0488	(ABC) transporter
GCD22_03786	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GCD22_03787	COG0732	type I restriction modification DNA specificity domain
GCD22_03788	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GCD22_03790	COG0594	ribonuclease P activity
GCD22_03792	COG0706	membrane insertase activity
GCD22_03793	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GCD22_03795	COG1560	Kdo2-lipid A biosynthetic process
GCD22_03796	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GCD22_03798	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GCD22_03802	COG1530	ribonuclease E activity
GCD22_03803	COG1555	photosystem II stabilization
GCD22_03805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GCD22_03806	COG0352	thiamine-phosphate diphosphorylase activity
GCD22_03807	COG0352	thiamine-phosphate diphosphorylase activity
GCD22_03807	COG0351	phosphomethylpyrimidine kinase