locus-tag	class	description
IPM50_00030	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IPM50_00060	COG0464	growth
IPM50_00100	COG2204	response regulator
IPM50_00155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPM50_00170	COG0602	queuosine metabolic process
IPM50_00190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPM50_00200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPM50_00205	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IPM50_00220	COG1431	PFAM Stem cell self-renewal protein Piwi
IPM50_00240	COG1914	H( )-stimulated, divalent metal cation uptake system
IPM50_00250	COG1984	allophanate hydrolase subunit 2
IPM50_00255	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IPM50_00260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPM50_00270	COG2226	methyltransferase
IPM50_00305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IPM50_00315	COG0644	oxidoreductase
IPM50_00315	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IPM50_00320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPM50_00325	COG0631	protein serine/threonine phosphatase activity
IPM50_00335	COG0768	penicillin binding
IPM50_00365	COG0515	serine threonine protein kinase
IPM50_00365	COG2815	serine threonine protein kinase
IPM50_00375	COG3557	Belongs to the UPF0374 family
IPM50_00395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPM50_00400	COG0179	Fumarylacetoacetate (FAA) hydrolase
IPM50_00410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IPM50_00415	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IPM50_00420	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IPM50_00435	COG1381	Involved in DNA repair and RecF pathway recombination
IPM50_00445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IPM50_00450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IPM50_00460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPM50_00470	COG0825	malonyl-CoA metabolic process
IPM50_00475	COG0629	single-stranded DNA binding
IPM50_00520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM50_00530	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IPM50_00535	COG1086	Polysaccharide biosynthesis protein
IPM50_00545	COG0859	PFAM glycosyl transferase family 9
IPM50_00550	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPM50_00550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPM50_00555	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IPM50_00565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPM50_00590	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IPM50_00595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM50_00600	COG0489	protein tyrosine kinase activity
IPM50_00610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IPM50_00615	COG1472	Belongs to the glycosyl hydrolase 3 family
IPM50_00620	COG0747	negative chemotaxis
IPM50_00675	COG0493	'glutamate synthase
IPM50_00675	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IPM50_00710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPM50_00730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPM50_00745	COG1132	(ABC) transporter
IPM50_00760	COG0017	Asparaginyl-tRNA synthetase
IPM50_00805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IPM50_00810	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPM50_00815	COG0183	Belongs to the thiolase family
IPM50_00820	COG0427	acetyl-CoA hydrolase
IPM50_00835	COG0442	prolyl-tRNA aminoacylation
IPM50_00840	COG1595	DNA-templated transcription, initiation
IPM50_00855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IPM50_00860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IPM50_00885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPM50_00890	COG2226	methyltransferase
IPM50_00900	COG0126	phosphoglycerate kinase activity
IPM50_00905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IPM50_00935	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPM50_00945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPM50_00955	COG1660	Displays ATPase and GTPase activities
IPM50_00960	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IPM50_00965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IPM50_00975	COG1137	ATPase activity
IPM50_00985	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IPM50_00985	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IPM50_00990	COG1968	undecaprenyl-diphosphatase activity
IPM50_01005	COG0300	oxidoreductase activity
IPM50_01015	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IPM50_01025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPM50_01035	COG0552	protein localization to endoplasmic reticulum
IPM50_01045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IPM50_01045	COG2199	diguanylate cyclase activity
IPM50_01050	COG2208	phosphoserine phosphatase activity
IPM50_01050	COG2770	Histidine kinase
IPM50_01060	COG0515	serine threonine protein kinase
IPM50_01060	COG2815	serine threonine protein kinase
IPM50_01065	COG1716	ATPase activity
IPM50_01075	COG1136	(ABC) transporter
IPM50_01100	COG4608	Belongs to the ABC transporter superfamily
IPM50_01110	COG0793	Belongs to the peptidase S41A family
IPM50_01110	COG4946	Tricorn protease homolog
IPM50_01115	COG0793	Belongs to the peptidase S41A family
IPM50_01130	COG1506	peptidase
IPM50_01130	COG0823	Involved in the tonB-independent uptake of proteins
IPM50_01140	COG2322	membrane
IPM50_01150	COG0109	protoheme IX farnesyltransferase activity
IPM50_01160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IPM50_01180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPM50_01275	COG3209	COG3209 Rhs family protein
IPM50_01295	COG1028	Short-chain dehydrogenase reductase Sdr
IPM50_01305	COG2986	histidine ammonia-lyase
IPM50_01310	COG1228	amidohydrolase
IPM50_01325	COG0010	Belongs to the arginase family
IPM50_01335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IPM50_01340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPM50_01345	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IPM50_01350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IPM50_01355	COG0156	8-amino-7-oxononanoate synthase activity
IPM50_01390	COG1063	alcohol dehydrogenase
IPM50_01400	COG0072	phenylalanine-tRNA ligase activity
IPM50_01400	COG0072	phenylalanine-tRNA ligase activity
IPM50_01435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPM50_01445	COG0386	Belongs to the glutathione peroxidase family
IPM50_01465	COG0561	phosphatase activity
IPM50_01475	COG1490	D-aminoacyl-tRNA deacylase activity
IPM50_01520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IPM50_01545	COG0405	Gamma-glutamyltransferase
IPM50_01555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPM50_01590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IPM50_01600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IPM50_01600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPM50_01605	COG1054	Belongs to the UPF0176 family
IPM50_01610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPM50_01620	COG1012	belongs to the aldehyde dehydrogenase family
IPM50_01635	COG0242	peptide deformylase activity
IPM50_01665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM50_01665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM50_01695	COG1024	Enoyl-CoA hydratase
IPM50_01710	COG1024	Enoyl-CoA hydratase
IPM50_01715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IPM50_01730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPM50_01785	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IPM50_01790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPM50_01800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPM50_01805	COG1459	type II secretion system
IPM50_01840	COG1426	Protein conserved in bacteria
IPM50_01845	COG0517	IMP dehydrogenase activity
IPM50_01845	COG0516	GMP reductase activity
IPM50_01855	COG0488	(ABC) transporter
IPM50_01865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IPM50_01870	COG0251	oxidation-reduction process
IPM50_01905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM50_01910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM50_01915	COG1862	Preprotein translocase
IPM50_01920	COG0343	queuine tRNA-ribosyltransferase activity
IPM50_01930	COG1160	GTP binding
IPM50_01940	COG0517	IMP dehydrogenase activity
IPM50_01940	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IPM50_01945	COG2373	Large extracellular alpha-helical protein
IPM50_01985	COG1595	DNA-templated transcription, initiation
IPM50_02000	COG0515	serine threonine protein kinase
IPM50_02000	COG2815	serine threonine protein kinase
IPM50_02020	COG0339	signal peptide processing
IPM50_02025	COG2204	response regulator
IPM50_02030	COG5000	phosphorelay sensor kinase activity
IPM50_02050	COG0525	valine-tRNA ligase activity
IPM50_02060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IPM50_02085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPM50_02090	COG0772	Belongs to the SEDS family
IPM50_02095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPM50_02100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM50_02105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPM50_02130	COG0688	phosphatidylethanolamine metabolic process
IPM50_02135	COG1183	phosphatidylcholine synthase activity
IPM50_02140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPM50_02145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IPM50_02150	COG1295	ribonuclease BN
IPM50_02155	COG0515	serine threonine protein kinase
IPM50_02155	COG2815	serine threonine protein kinase
IPM50_02180	COG1716	ATPase activity
IPM50_02200	COG1666	GTP binding
IPM50_02220	COG1595	DNA-templated transcription, initiation
IPM50_02240	COG0084	hydrolase, TatD family'
IPM50_02260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM50_02260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM50_02270	COG0302	gtp cyclohydrolase
IPM50_02275	COG0018	arginyl-trna synthetase
IPM50_02280	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IPM50_02310	COG0612	Peptidase, M16
IPM50_02320	COG0793	Belongs to the peptidase S41A family
IPM50_02330	COG2304	oxidoreductase activity
IPM50_02350	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IPM50_02360	COG1132	(ABC) transporter
IPM50_02365	COG1561	YicC-like family, N-terminal region
IPM50_02370	COG0194	GDP metabolic process
IPM50_02375	COG1758	RNA polymerase activity
IPM50_02395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IPM50_02420	COG1166	arginine decarboxylase activity
IPM50_02430	COG0010	Belongs to the arginase family
IPM50_02490	COG1285	pathogenesis
IPM50_02555	COG4771	TonB-dependent receptor
IPM50_02560	COG4191	Histidine kinase
IPM50_02565	COG2204	response regulator
IPM50_02840	COG2217	Heavy metal translocating P-type atpase
IPM50_02870	COG2132	Multicopper oxidase
IPM50_02900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPM50_02935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPM50_02960	COG2205	protein histidine kinase activity
IPM50_03085	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IPM50_03155	COG0328	RNA-DNA hybrid ribonuclease activity
IPM50_03160	COG0629	single-stranded DNA binding
IPM50_03175	COG0629	single-stranded DNA binding
IPM50_03180	COG1431	PFAM Stem cell self-renewal protein Piwi
IPM50_03245	COG2856	Zn peptidase
IPM50_03270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IPM50_03290	COG0215	cysteine-tRNA ligase activity
IPM50_03310	COG4232	protein-disulfide reductase activity
IPM50_03320	COG0022	dehydrogenase e1 component
IPM50_03320	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM50_03325	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM50_03345	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPM50_03360	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IPM50_03370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM50_03370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM50_03385	COG0792	nuclease activity
IPM50_03410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IPM50_03415	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IPM50_03425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPM50_03430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IPM50_03450	COG2815	serine threonine protein kinase
IPM50_03450	COG0515	serine threonine protein kinase
IPM50_03460	COG5016	pyruvate
IPM50_03460	COG0511	ligase activity, forming carbon-carbon bonds
IPM50_03470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPM50_03475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IPM50_03480	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IPM50_03495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IPM50_03520	COG0509	glycine decarboxylation via glycine cleavage system
IPM50_03525	COG4946	Tricorn protease homolog
IPM50_03525	COG0823	Involved in the tonB-independent uptake of proteins
IPM50_03525	COG1506	peptidase
IPM50_03545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPM50_03555	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPM50_03575	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IPM50_03580	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IPM50_03635	COG0646	methionine synthase
IPM50_03635	COG1410	methionine synthase
IPM50_03650	COG0006	proline dipeptidase activity
IPM50_03670	COG1022	Amp-dependent synthetase and ligase
IPM50_03685	COG2205	protein histidine kinase activity
IPM50_03690	COG0745	RESPONSE REGULATOR receiver
IPM50_03695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM50_03705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPM50_03710	COG1472	Belongs to the glycosyl hydrolase 3 family
IPM50_03725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IPM50_03730	COG0277	FAD linked oxidase domain protein
IPM50_03735	COG0556	nucleotide-excision repair
IPM50_03765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPM50_03770	COG0459	protein refolding
IPM50_03775	COG4968	Prepilin-type N-terminal cleavage methylation domain
IPM50_03800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IPM50_03805	COG0724	RNA recognition motif
IPM50_03830	COG4152	abc transporter atp-binding protein
IPM50_03845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPM50_03850	COG0598	Magnesium transport protein CorA
IPM50_03855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IPM50_03865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IPM50_03875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IPM50_03880	COG0195	Participates in both transcription termination and antitermination
IPM50_03885	COG0779	Required for maturation of 30S ribosomal subunits
IPM50_03890	COG1940	carbohydrate kinase activity
IPM50_03905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IPM50_03940	COG1595	DNA-templated transcription, initiation
IPM50_03950	COG4537	Required for transformation and DNA binding
IPM50_03960	COG1450	Type ii and iii secretion system protein
IPM50_03965	COG1546	Belongs to the CinA family
IPM50_03965	COG1058	Belongs to the CinA family
IPM50_03980	COG1573	uracil-dna glycosylase
IPM50_03985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IPM50_03990	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IPM50_03995	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IPM50_04015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPM50_04020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IPM50_04025	COG0052	Belongs to the universal ribosomal protein uS2 family
IPM50_04030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IPM50_04040	COG0528	UMP kinase activity
IPM50_04045	COG0233	cytoplasmic translational termination
IPM50_04075	COG0824	Thioesterase
IPM50_04085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPM50_04090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPM50_04100	COG0045	succinate-CoA ligase (ADP-forming) activity
IPM50_04115	COG0305	Participates in initiation and elongation during chromosome replication
IPM50_04120	COG0359	binds to the 23S rRNA
IPM50_04125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPM50_04130	COG0360	Binds together with S18 to 16S ribosomal RNA
IPM50_04135	COG0193	aminoacyl-tRNA hydrolase activity
IPM50_04140	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IPM50_04145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IPM50_04155	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IPM50_04180	COG3710	Transcriptional regulator
IPM50_04180	COG0457	Tetratricopeptide repeat
IPM50_04215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IPM50_04215	COG0189	ligase activity
IPM50_04225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IPM50_04235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPM50_04245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPM50_04265	COG0539	negative regulation of cytoplasmic translation
IPM50_04270	COG0776	regulation of translation
IPM50_04280	COG1480	7TM receptor with intracellular HD hydrolase
IPM50_04290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IPM50_04300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IPM50_04310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM50_04310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM50_04370	COG0425	Belongs to the sulfur carrier protein TusA family
IPM50_04370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPM50_04385	COG2815	serine threonine protein kinase
IPM50_04385	COG0515	serine threonine protein kinase
IPM50_04415	COG2264	protein methyltransferase activity
IPM50_04420	COG0438	transferase activity, transferring glycosyl groups
IPM50_04430	COG0367	asparagine synthase
IPM50_04445	COG0438	transferase activity, transferring glycosyl groups
IPM50_04450	COG5434	Belongs to the glycosyl hydrolase 28 family
IPM50_04490	COG1022	Amp-dependent synthetase and ligase
IPM50_04500	COG0606	chelatase, subunit chli
IPM50_04505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM50_04510	COG1293	RNA-binding protein homologous to eukaryotic snRNP
IPM50_04530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPM50_04545	COG1252	NADH dehydrogenase
IPM50_04610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IPM50_04625	COG1322	Protein conserved in bacteria
IPM50_04630	COG0328	RNA-DNA hybrid ribonuclease activity
IPM50_04640	COG2264	protein methyltransferase activity
IPM50_04645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IPM50_04655	COG1366	Belongs to the anti-sigma-factor antagonist family
IPM50_04680	COG1652	LysM domain
IPM50_04680	COG2823	Periplasmic or secreted lipoprotein
IPM50_04685	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IPM50_04690	COG0318	PFAM AMP-dependent synthetase and ligase
IPM50_04695	COG2010	Cytochrome c
IPM50_04700	COG1090	epimerase
IPM50_04705	COG0604	alcohol dehydrogenase
IPM50_04705	COG1028	Short-chain dehydrogenase reductase Sdr
IPM50_04705	COG3321	synthase
IPM50_04710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPM50_04715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IPM50_04720	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IPM50_04730	COG1100	Small GTP-binding protein
IPM50_04740	COG0612	Peptidase, M16
IPM50_04765	COG0515	serine threonine protein kinase
IPM50_04765	COG2815	serine threonine protein kinase
IPM50_04780	COG4447	cellulose binding
IPM50_04790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPM50_04795	COG0489	protein tyrosine kinase activity
IPM50_04800	COG3409	Peptidoglycan-binding domain 1 protein
IPM50_04800	COG3267	Type II secretory pathway component ExeA
IPM50_04845	COG0724	RNA recognition motif
IPM50_04850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPM50_04875	COG0590	tRNA wobble adenosine to inosine editing
IPM50_04880	COG3238	Protein conserved in bacteria
IPM50_04885	COG2720	vancomycin resistance protein
IPM50_04910	COG0386	Belongs to the glutathione peroxidase family
IPM50_04915	COG0471	metal ion transport
IPM50_04915	COG3273	potassium ion transport
IPM50_04920	COG0471	metal ion transport
IPM50_04920	COG3273	potassium ion transport
IPM50_04930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM50_04960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPM50_04970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPM50_04970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPM50_04990	COG0484	heat shock protein binding
IPM50_04995	COG2770	Histidine kinase
IPM50_04995	COG3437	response regulator, receiver
IPM50_05015	COG4772	TonB-dependent receptor
IPM50_05020	COG1024	Enoyl-CoA hydratase
IPM50_05030	COG0123	including yeast histone deacetylase and acetoin utilization protein
IPM50_05055	COG0254	rRNA binding
IPM50_05060	COG3872	metal-dependent enzyme
IPM50_05065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPM50_05070	COG0406	alpha-ribazole phosphatase activity
IPM50_05095	COG2198	Histidine kinase
IPM50_05095	COG0643	Histidine kinase
IPM50_05100	COG1028	Short-chain dehydrogenase reductase Sdr
IPM50_05105	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPM50_05115	COG4206	TonB-dependent receptor
IPM50_05120	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IPM50_05125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IPM50_05130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IPM50_05140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IPM50_05145	COG3383	formate dehydrogenase (NAD+) activity
IPM50_05150	COG3844	kynureninase activity
IPM50_05165	COG0662	Cupin 2, conserved barrel domain protein
IPM50_05175	COG1064	alcohol dehydrogenase
IPM50_05190	COG2195	Cleaves the N-terminal amino acid of tripeptides
IPM50_05200	COG0717	Belongs to the dCTP deaminase family
IPM50_05240	COG0515	serine threonine protein kinase
IPM50_05240	COG2815	serine threonine protein kinase
IPM50_05260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IPM50_05275	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IPM50_05295	COG3621	Patatin-like phospholipase
IPM50_05300	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IPM50_05350	COG0300	oxidoreductase activity
IPM50_05375	COG0314	molybdopterin synthase activity
IPM50_05385	COG2022	thiamine diphosphate biosynthetic process
IPM50_05405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM50_05410	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM50_05415	COG0649	NAD binding
IPM50_05420	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IPM50_05455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IPM50_05460	COG0839	Belongs to the complex I subunit 6 family
IPM50_05465	COG0713	ATP synthesis coupled electron transport
IPM50_05470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IPM50_05485	COG1007	ATP synthesis coupled electron transport
IPM50_05495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IPM50_05495	COG0519	Catalyzes the synthesis of GMP from XMP
IPM50_05500	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IPM50_05510	COG0626	cystathionine gamma-synthase activity
IPM50_05540	COG1404	Belongs to the peptidase S8 family
IPM50_05560	COG0741	lytic transglycosylase activity
IPM50_05565	COG0402	S-adenosylhomocysteine deaminase activity
IPM50_05585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IPM50_05595	COG0237	dephospho-CoA kinase activity
IPM50_05600	COG4166	transmembrane transport
IPM50_05610	COG0601	transmembrane transport
IPM50_05620	COG0444	Belongs to the ABC transporter superfamily
IPM50_05625	COG4608	Belongs to the ABC transporter superfamily
IPM50_05645	COG0728	peptidoglycan biosynthetic process
IPM50_05650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IPM50_05655	COG0124	histidyl-tRNA synthetase
IPM50_05660	COG0659	secondary active sulfate transmembrane transporter activity
IPM50_05670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IPM50_05675	COG0750	zinc metalloprotease
IPM50_05680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IPM50_05690	COG0470	DNA polymerase III
IPM50_05700	COG1923	regulation of RNA biosynthetic process
IPM50_05705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IPM50_05720	COG2385	sporulation resulting in formation of a cellular spore
IPM50_05720	COG2385	sporulation resulting in formation of a cellular spore
IPM50_05745	COG0745	RESPONSE REGULATOR receiver
IPM50_05770	COG0372	Belongs to the citrate synthase family
IPM50_05810	COG0577	efflux transmembrane transporter activity
IPM50_05810	COG1136	(ABC) transporter
IPM50_05835	COG1272	protein, Hemolysin III
IPM50_05840	COG0492	ferredoxin-NADP+ reductase activity
IPM50_05855	COG0489	protein tyrosine kinase activity
IPM50_05880	COG0316	Belongs to the HesB IscA family
IPM50_05895	COG4770	biotin carboxylase activity
IPM50_05910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IPM50_05915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPM50_05920	COG0205	6-phosphofructokinase activity
IPM50_05925	COG0793	Belongs to the peptidase S41A family
IPM50_05945	COG2855	membrane
IPM50_05955	COG0588	phosphoglycerate mutase activity
IPM50_05960	COG0285	dihydrofolate synthase activity
IPM50_05965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IPM50_05970	COG0483	inositol monophosphate 1-phosphatase activity
IPM50_06005	COG0590	tRNA wobble adenosine to inosine editing
IPM50_06015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IPM50_06030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPM50_06045	COG1704	LemA family
IPM50_06060	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IPM50_06065	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IPM50_06075	COG0235	Class ii aldolase
IPM50_06085	COG0632	four-way junction helicase activity
IPM50_06090	COG2255	four-way junction helicase activity
IPM50_06140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IPM50_06145	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IPM50_06150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IPM50_06165	COG0720	synthase
IPM50_06170	COG1199	ATP-dependent helicase activity
IPM50_06245	COG1953	Uracil, thiamine, allantoin
IPM50_06260	COG0515	serine threonine protein kinase
IPM50_06260	COG2815	serine threonine protein kinase
IPM50_06305	COG0515	serine threonine protein kinase
IPM50_06310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM50_06325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM50_06365	COG2205	protein histidine kinase activity
IPM50_06415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IPM50_06435	COG0318	PFAM AMP-dependent synthetase and ligase
IPM50_06445	COG0166	Belongs to the GPI family
IPM50_06475	COG0577	efflux transmembrane transporter activity
IPM50_06500	COG1136	(ABC) transporter
IPM50_06505	COG0577	efflux transmembrane transporter activity
IPM50_06515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IPM50_06555	COG0484	heat shock protein binding
IPM50_06560	COG0443	Heat shock 70 kDa protein
IPM50_06565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPM50_06570	COG1420	regulation of RNA biosynthetic process
IPM50_06585	COG1028	Short-chain dehydrogenase reductase Sdr
IPM50_06600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IPM50_06605	COG1663	tetraacyldisaccharide 4'-kinase activity
IPM50_06610	COG0628	permease
IPM50_06645	COG2192	nodulation
IPM50_06665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IPM50_06675	COG3494	Protein of unknown function (DUF1009)
IPM50_06685	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IPM50_06710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPM50_06710	COG0574	Belongs to the PEP-utilizing enzyme family
IPM50_06715	COG1494	fructose-1,6-bisphosphatase
IPM50_06720	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IPM50_06725	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IPM50_06735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IPM50_06745	COG1045	serine acetyltransferase
IPM50_06765	COG0493	'glutamate synthase
IPM50_06765	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IPM50_06775	COG0242	peptide deformylase activity
IPM50_06785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IPM50_06795	COG1028	Short-chain dehydrogenase reductase Sdr
IPM50_06800	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IPM50_06805	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IPM50_06810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPM50_06825	COG2226	methyltransferase
IPM50_06830	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IPM50_06845	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IPM50_06860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IPM50_06870	COG2313	pseudouridylate synthase activity
IPM50_06880	COG0571	ribonuclease III activity
IPM50_06895	COG4191	Histidine kinase
IPM50_06935	COG1819	glycosyl
IPM50_06950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPM50_06955	COG1519	Transferase
IPM50_06975	COG0356	it plays a direct role in the translocation of protons across the membrane
IPM50_06980	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPM50_06985	COG2815	serine threonine protein kinase
IPM50_06985	COG0515	serine threonine protein kinase
IPM50_07000	COG2204	response regulator
IPM50_07005	COG2226	methyltransferase
IPM50_07010	COG0616	signal peptide processing
IPM50_07015	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IPM50_07030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IPM50_07055	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IPM50_07085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IPM50_07090	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IPM50_07150	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IPM50_07170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPM50_07180	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM50_07180	COG0567	Dehydrogenase, E1 component
IPM50_07220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IPM50_07225	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPM50_07230	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IPM50_07245	COG0210	DNA helicase
IPM50_07265	COG3956	TIGRFAM MazG family protein
IPM50_07275	COG0321	lipoyl(octanoyl) transferase activity
IPM50_07275	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IPM50_07290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPM50_07365	COG0492	ferredoxin-NADP+ reductase activity
IPM50_07375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPM50_07435	COG1024	Enoyl-CoA hydratase
IPM50_07445	COG0492	ferredoxin-NADP+ reductase activity
IPM50_07465	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IPM50_07485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPM50_07500	COG0463	Glycosyl transferase, family 2
IPM50_07510	COG0367	asparagine synthase
IPM50_07520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPM50_07560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPM50_07565	COG0196	riboflavin kinase activity
IPM50_07580	COG0519	Catalyzes the synthesis of GMP from XMP
IPM50_07580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IPM50_07600	COG0513	Belongs to the DEAD box helicase family
IPM50_07615	COG1309	transcriptional regulator
IPM50_07645	COG3320	Male sterility
IPM50_07645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPM50_07665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPM50_07670	COG1765	OsmC-like protein
IPM50_07705	COG0022	dehydrogenase e1 component
IPM50_07715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPM50_07745	COG1960	acyl-CoA dehydrogenase activity
IPM50_07755	COG0490	domain, Protein
IPM50_07755	COG0471	metal ion transport
IPM50_07760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM50_07770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IPM50_07775	COG2267	carboxylic ester hydrolase activity
IPM50_07780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IPM50_07790	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IPM50_07795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPM50_07800	COG2197	response regulator
IPM50_07815	COG3657	addiction module killer protein
IPM50_07820	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IPM50_07840	COG0460	homoserine dehydrogenase
IPM50_07840	COG0527	aspartate kinase activity
IPM50_07850	COG0083	homoserine kinase activity
IPM50_07855	COG0542	response to heat
IPM50_07870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM50_07875	COG0415	Belongs to the DNA photolyase family
IPM50_07880	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IPM50_07890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IPM50_07915	COG0515	serine threonine protein kinase
IPM50_07915	COG2815	serine threonine protein kinase
IPM50_07935	COG1196	nuclear chromosome segregation
IPM50_07950	COG0789	Transcriptional regulator
IPM50_07960	COG0443	Heat shock 70 kDa protein
IPM50_07970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IPM50_07975	COG1408	metallophosphoesterase
IPM50_07980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPM50_07985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IPM50_07995	COG0542	response to heat
IPM50_08005	COG0280	phosphate acetyltransferase
IPM50_08015	COG4242	Belongs to the peptidase S51 family
IPM50_08020	COG1560	Kdo2-lipid A biosynthetic process
IPM50_08060	COG1132	(ABC) transporter
IPM50_08070	COG1388	LysM domain
IPM50_08070	COG3584	3D domain protein
IPM50_08105	COG0746	molybdenum cofactor guanylyltransferase activity
IPM50_08115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPM50_08125	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IPM50_08135	COG0076	glutamate decarboxylase activity
IPM50_08140	COG1136	(ABC) transporter
IPM50_08175	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IPM50_08190	COG0723	plastoquinol--plastocyanin reductase activity
IPM50_08220	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IPM50_08235	COG0730	response to heat
IPM50_08250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPM50_08265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPM50_08305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPM50_08315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPM50_08350	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM50_08370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IPM50_08370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPM50_08385	COG2172	sigma factor antagonist activity
IPM50_08395	COG0109	protoheme IX farnesyltransferase activity
IPM50_08395	COG1612	heme a metabolic process
IPM50_08400	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IPM50_08410	COG0640	Transcriptional regulator
IPM50_08420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IPM50_08425	COG0542	response to heat
IPM50_08435	COG1543	Belongs to the glycosyl hydrolase 57 family
IPM50_08450	COG1404	Belongs to the peptidase S8 family
IPM50_08455	COG1752	Esterase of the alpha-beta hydrolase superfamily
IPM50_08470	COG2351	hydroxyisourate hydrolase activity
IPM50_08485	COG3422	double-strand break repair
IPM50_08490	COG3876	Protein conserved in bacteria
IPM50_08505	COG0433	COG0433 Predicted ATPase
IPM50_08520	COG0432	Pfam Uncharacterised protein family UPF0047
IPM50_08525	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IPM50_08535	COG0505	Belongs to the CarA family
IPM50_08540	COG0681	Belongs to the peptidase S26 family
IPM50_08555	COG1595	DNA-templated transcription, initiation
IPM50_08570	COG3279	Response regulator of the LytR AlgR family
IPM50_08575	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IPM50_08585	COG4206	TonB-dependent receptor
IPM50_08595	COG3706	GGDEF domain
IPM50_08610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IPM50_08610	COG2199	diguanylate cyclase activity
IPM50_08615	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPM50_08625	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM50_08625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM50_08635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IPM50_08655	COG0859	PFAM glycosyl transferase family 9
IPM50_08680	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IPM50_08710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IPM50_08720	COG0471	metal ion transport
IPM50_08725	COG1115	amino acid carrier protein
IPM50_08730	COG0076	glutamate decarboxylase activity
IPM50_08765	COG1231	oxidoreductase activity
IPM50_08790	COG0745	RESPONSE REGULATOR receiver
IPM50_08835	COG0456	acetyltransferase
IPM50_08845	COG3963	phosphatidate phosphatase activity
IPM50_08850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPM50_08855	COG0758	DNA mediated transformation
IPM50_08880	COG5507	3-demethylubiquinone-9 3-methyltransferase
IPM50_08885	COG0534	Mate efflux family protein
IPM50_08890	COG0592	DNA-directed DNA polymerase activity
IPM50_08920	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IPM50_08925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IPM50_08930	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IPM50_08935	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPM50_08940	COG0706	membrane insertase activity
IPM50_08970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IPM50_08995	COG2204	response regulator
IPM50_09015	COG3005	denitrification pathway
IPM50_09030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPM50_09055	COG0445	tRNA wobble uridine modification
IPM50_09060	COG1192	Involved in chromosome partitioning
IPM50_09065	COG1475	DNA binding
IPM50_09070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPM50_09075	COG0805	protein transport
IPM50_09090	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IPM50_09110	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IPM50_09125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM50_09130	COG0436	Aminotransferase
IPM50_09140	COG1022	Amp-dependent synthetase and ligase
IPM50_09145	COG1309	transcriptional regulator
IPM50_09365	COG0653	protein targeting
IPM50_09435	COG2369	cell adhesion
IPM50_09465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPM50_09475	COG0187	DNA topoisomerase II activity
IPM50_09480	COG3710	Transcriptional regulator
IPM50_09480	COG0457	Tetratricopeptide repeat
IPM50_09500	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IPM50_09520	COG0534	Mate efflux family protein
IPM50_09530	COG0482	sulfurtransferase activity
IPM50_09535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IPM50_09540	COG1970	mechanosensitive ion channel activity
IPM50_09550	COG0037	tRNA processing
IPM50_09590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM50_09605	COG0823	Involved in the tonB-independent uptake of proteins
IPM50_09605	COG1506	peptidase
IPM50_09605	COG4946	Tricorn protease homolog
IPM50_09615	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IPM50_09620	COG1077	Cell shape determining protein MreB Mrl
IPM50_09635	COG3829	transcription factor binding
IPM50_09640	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IPM50_09655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPM50_09670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IPM50_09675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IPM50_09690	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IPM50_09700	COG3609	addiction module antidote protein, CC2985 family
IPM50_09710	COG0137	argininosuccinate synthase activity
IPM50_09720	COG0165	Argininosuccinate lyase
IPM50_09725	COG2050	protein possibly involved in aromatic compounds catabolism
IPM50_09730	COG0037	tRNA processing
IPM50_09735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPM50_09740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IPM50_09765	COG0352	thiamine-phosphate diphosphorylase activity
IPM50_09775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IPM50_09800	COG2204	response regulator
IPM50_09815	COG0357	Ribosomal RNA small subunit methyltransferase G
IPM50_09825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IPM50_09835	COG1872	DUF167
IPM50_09840	COG0217	transcriptional regulatory protein
IPM50_09860	COG4603	Belongs to the binding-protein-dependent transport system permease family
IPM50_09865	COG1079	Belongs to the binding-protein-dependent transport system permease family
IPM50_09880	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IPM50_09885	COG0572	uridine kinase
IPM50_09900	COG0402	S-adenosylhomocysteine deaminase activity
IPM50_09930	COG0719	Fe-S assembly protein
IPM50_09935	COG0396	ATPase activity
IPM50_09945	COG0719	Fe-S assembly protein
IPM50_09955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPM50_09960	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IPM50_09975	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IPM50_10000	COG2890	protein-(glutamine-N5) methyltransferase activity
IPM50_10020	COG0481	GTPase activity
IPM50_10035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM50_10035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM50_10040	COG1132	(ABC) transporter
IPM50_10110	COG0012	GTP binding
IPM50_10125	COG1473	amidohydrolase
IPM50_10130	COG0783	Belongs to the Dps family
IPM50_10155	COG3706	GGDEF domain
IPM50_10160	COG0071	Belongs to the small heat shock protein (HSP20) family
IPM50_10165	COG0542	response to heat
IPM50_10170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPM50_10175	COG0542	response to heat
IPM50_10190	COG1530	ribonuclease E activity
IPM50_10190	COG1530	ribonuclease E activity
IPM50_10195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM50_10195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM50_10225	COG2832	Protein of unknown function (DUF454)
IPM50_10230	COG3384	dioxygenase
IPM50_10255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPM50_10305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IPM50_10335	COG2204	response regulator
IPM50_10345	COG0537	adenosine 5'-monophosphoramidase activity
IPM50_10350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPM50_10415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPM50_10435	COG1819	glycosyl
IPM50_10465	COG2249	NAD(P)H dehydrogenase (quinone) activity
IPM50_10475	COG1522	sequence-specific DNA binding
IPM50_10480	COG3186	Phenylalanine-4-hydroxylase
IPM50_10495	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IPM50_10510	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IPM50_10520	COG1764	response to oxidative stress
IPM50_10525	COG0666	response to abiotic stimulus
IPM50_10540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPM50_10585	COG3177	Filamentation induced by cAMP protein fic
IPM50_10595	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IPM50_10615	COG4974	Belongs to the 'phage' integrase family
IPM50_10645	COG4948	Mandelate Racemase Muconate Lactonizing
IPM50_10650	COG3609	addiction module antidote protein, CC2985 family
IPM50_10665	COG0488	(ABC) transporter
IPM50_10685	COG2080	2 iron, 2 sulfur cluster binding
IPM50_10690	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IPM50_10695	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IPM50_10720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IPM50_10740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IPM50_10745	COG0081	regulation of translation
IPM50_10750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IPM50_10755	COG0222	ribosome binding
IPM50_10760	COG0085	RNA polymerase activity
IPM50_10765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPM50_10780	COG1078	dGTPase activity
IPM50_10785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPM50_10790	COG2442	InterPro IPR007367
IPM50_10800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IPM50_10810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IPM50_10820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPM50_10830	COG0823	Involved in the tonB-independent uptake of proteins
IPM50_10840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IPM50_10860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IPM50_10875	COG1496	oxidoreductase activity
IPM50_10880	COG0736	holo-[acyl-carrier-protein] synthase activity
IPM50_10895	COG2234	aminopeptidase activity
IPM50_10930	COG0438	transferase activity, transferring glycosyl groups
IPM50_10935	COG2815	serine threonine protein kinase
IPM50_10935	COG0515	serine threonine protein kinase
IPM50_10940	COG2326	polyphosphate kinase activity
IPM50_10945	COG2133	pyrroloquinoline quinone binding
IPM50_10960	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IPM50_10990	COG2207	Transcriptional regulator
IPM50_10990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IPM50_10995	COG0346	lactoylglutathione lyase activity
IPM50_11025	COG0438	transferase activity, transferring glycosyl groups
IPM50_11035	COG1073	alpha beta
IPM50_11035	COG2226	methyltransferase
IPM50_11050	COG0297	glycogen (starch) synthase activity
IPM50_11050	COG0438	transferase activity, transferring glycosyl groups
IPM50_11055	COG0438	transferase activity, transferring glycosyl groups
IPM50_11065	COG2192	nodulation
IPM50_11075	COG0367	asparagine synthase
IPM50_11085	COG0438	transferase activity, transferring glycosyl groups
IPM50_11090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM50_11130	COG1074	ATP-dependent DNA helicase activity
IPM50_11145	COG2226	methyltransferase
IPM50_11150	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPM50_11165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IPM50_11170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IPM50_11170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPM50_11190	COG1830	Aldolase
IPM50_11200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPM50_11205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPM50_11240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPM50_11250	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPM50_11260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IPM50_11310	COG0475	glutathione-regulated potassium exporter activity
IPM50_11320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPM50_11335	COG1459	type II secretion system
IPM50_11355	COG2321	neutral zinc metallopeptidase
IPM50_11375	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IPM50_11385	COG2211	Major facilitator Superfamily
IPM50_11400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IPM50_11405	COG0573	inorganic phosphate transmembrane transporter activity
IPM50_11410	COG0581	inorganic phosphate transmembrane transporter activity
IPM50_11415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IPM50_11425	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IPM50_11430	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IPM50_11435	COG0517	IMP dehydrogenase activity
IPM50_11450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPM50_11520	COG0772	Belongs to the SEDS family
IPM50_11540	COG0321	lipoyl(octanoyl) transferase activity
IPM50_11570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPM50_11580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IPM50_11595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IPM50_11600	COG2081	HI0933 family
IPM50_11615	COG2353	YceI-like domain
IPM50_11660	COG0497	DNA recombination
IPM50_11685	COG0543	2 iron, 2 sulfur cluster binding
IPM50_11685	COG0493	'glutamate synthase
IPM50_11690	COG0489	protein tyrosine kinase activity
IPM50_11695	COG0739	heme binding
IPM50_11695	COG0741	lytic transglycosylase activity
IPM50_11695	COG1196	nuclear chromosome segregation
IPM50_11700	COG2239	Acts as a magnesium transporter
IPM50_11735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM50_11740	COG2318	DinB family
IPM50_11745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IPM50_11750	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IPM50_11755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IPM50_11760	COG1649	PFAM Uncharacterised BCR, COG1649
IPM50_11765	COG0737	Belongs to the 5'-nucleotidase family
IPM50_11770	COG3483	tryptophan 2,3-dioxygenase activity
IPM50_11775	COG1278	Cold shock
IPM50_11785	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IPM50_11795	COG3132	Protein of unknown function, DUF480
IPM50_11815	COG1966	Carbon starvation protein
IPM50_11830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IPM50_11845	COG4589	Belongs to the CDS family
IPM50_11855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPM50_11865	COG0101	tRNA pseudouridine synthase activity
IPM50_11875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IPM50_11880	COG2176	DNA-directed DNA polymerase activity
IPM50_11895	COG5002	protein histidine kinase activity
IPM50_11900	COG0745	RESPONSE REGULATOR receiver
IPM50_11910	COG1028	Short-chain dehydrogenase reductase Sdr
IPM50_11955	COG0708	Exodeoxyribonuclease III
IPM50_11960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IPM50_11970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPM50_11975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IPM50_11990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IPM50_12010	COG2835	tetraacyldisaccharide 4'-kinase activity
IPM50_12015	COG0859	PFAM glycosyl transferase family 9
IPM50_12025	COG2239	Acts as a magnesium transporter
IPM50_12060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IPM50_12065	COG0228	four-way junction DNA binding
IPM50_12070	COG1837	Belongs to the UPF0109 family
IPM50_12075	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IPM50_12080	COG0336	Belongs to the RNA methyltransferase TrmD family
IPM50_12085	COG0335	large ribosomal subunit rRNA binding
IPM50_12090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IPM50_12095	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IPM50_12100	COG4221	oxidoreductase activity
IPM50_12115	COG0259	pyridoxamine-phosphate oxidase activity
IPM50_12130	COG2154	pterin-4-alpha-carbinolamine dehydratase
IPM50_12135	COG0473	3-isopropylmalate dehydrogenase activity
IPM50_12150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IPM50_12155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IPM50_12160	COG1956	GAF domain-containing protein
IPM50_12175	COG3875	lactate racemase activity
IPM50_12200	COG1301	dicarboxylic acid transport
IPM50_12205	COG1301	dicarboxylic acid transport
IPM50_12220	COG0584	glycerophosphoryl diester phosphodiesterase
IPM50_12225	COG2226	methyltransferase
IPM50_12235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPM50_12235	COG2022	thiamine diphosphate biosynthetic process
IPM50_12240	COG0473	3-isopropylmalate dehydrogenase activity
IPM50_12260	COG0515	serine threonine protein kinase
IPM50_12260	COG2815	serine threonine protein kinase
IPM50_12270	COG0006	proline dipeptidase activity
IPM50_12295	COG0602	queuosine metabolic process
IPM50_12305	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IPM50_12315	COG0612	Peptidase, M16
IPM50_12330	COG1297	OPT oligopeptide transporter protein
IPM50_12345	COG0673	inositol 2-dehydrogenase activity
IPM50_12355	COG1024	Enoyl-CoA hydratase
IPM50_12355	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPM50_12365	COG0519	Catalyzes the synthesis of GMP from XMP
IPM50_12380	COG0183	Belongs to the thiolase family
IPM50_12385	COG1960	acyl-CoA dehydrogenase activity
IPM50_12455	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPM50_12455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPM50_12480	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPM50_12500	COG0698	ribose 5-phosphate isomerase
IPM50_12505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM50_12530	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IPM50_12545	COG0154	amidase activity
IPM50_12555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPM50_12565	COG0424	maF-like protein
IPM50_12575	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IPM50_12580	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IPM50_12585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IPM50_12595	COG0463	Glycosyl transferase, family 2
IPM50_12620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPM50_12645	COG0315	cyclic pyranopterin monophosphate synthase activity
IPM50_12660	COG0515	serine threonine protein kinase
IPM50_12690	COG1960	acyl-CoA dehydrogenase activity
IPM50_12710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPM50_12720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IPM50_12740	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
IPM50_12765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM50_12780	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IPM50_12780	COG2199	diguanylate cyclase activity
IPM50_12785	COG0583	DNA-binding transcription factor activity
IPM50_12790	COG2009	succinate dehydrogenase
IPM50_12795	COG1053	succinate dehydrogenase
IPM50_12800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IPM50_12805	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IPM50_12815	COG0154	amidase activity
IPM50_12820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IPM50_12830	COG2720	vancomycin resistance protein
IPM50_12845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM50_12855	COG0495	leucyl-tRNA aminoacylation
IPM50_12860	COG0515	serine threonine protein kinase
IPM50_12860	COG2815	serine threonine protein kinase
IPM50_12870	COG0515	serine threonine protein kinase
IPM50_12870	COG2815	serine threonine protein kinase
IPM50_12875	COG1324	tolerance protein
IPM50_12885	COG1611	Belongs to the LOG family
IPM50_12890	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IPM50_12910	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IPM50_12920	COG0346	lactoylglutathione lyase activity
IPM50_12935	COG1960	acyl-CoA dehydrogenase activity
IPM50_12945	COG1187	pseudouridine synthase activity
IPM50_12950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IPM50_12955	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IPM50_12975	COG0180	Tryptophanyl-tRNA synthetase
IPM50_12980	COG1994	Peptidase M50
IPM50_13010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM50_13010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM50_13025	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IPM50_13030	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IPM50_13035	COG1674	ftsk spoiiie
IPM50_13045	COG0658	competence protein
IPM50_13045	COG2333	competence protein COMEC
IPM50_13055	COG0138	bifunctional purine biosynthesis protein purh
IPM50_13090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM50_13090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPM50_13110	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IPM50_13120	COG1217	gtp-binding protein TYPA
IPM50_13130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IPM50_13140	COG1595	DNA-templated transcription, initiation
IPM50_13160	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IPM50_13195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPM50_13210	COG3264	Mechanosensitive ion channel
IPM50_13210	COG1196	nuclear chromosome segregation
IPM50_13215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IPM50_13225	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IPM50_13225	COG0646	methionine synthase
IPM50_13235	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPM50_13250	COG0352	thiamine-phosphate diphosphorylase activity
IPM50_13265	COG1254	Belongs to the acylphosphatase family
IPM50_13270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IPM50_13280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IPM50_13280	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IPM50_13285	COG0802	atpase or kinase
IPM50_13290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IPM50_13310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IPM50_13315	COG4956	integral membrane protein (PIN domain superfamily)
IPM50_13325	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IPM50_13335	COG1744	ABC transporter substrate-binding protein PnrA-like
IPM50_13340	COG3845	ABC transporter
IPM50_13345	COG0436	Aminotransferase
IPM50_13350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IPM50_13380	COG0612	Peptidase, M16
IPM50_13385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM50_13390	COG0833	amino acid
IPM50_13415	COG0653	protein targeting
IPM50_13430	COG4581	dead DEAH box helicase
IPM50_13440	COG2226	methyltransferase
IPM50_13455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPM50_13460	COG1028	Short-chain dehydrogenase reductase Sdr
IPM50_13470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IPM50_13475	COG0527	aspartate kinase activity
IPM50_13480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPM50_13485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IPM50_13495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPM50_13500	COG2171	N-acyltransferase activity
IPM50_13510	COG0436	Aminotransferase
IPM50_13550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IPM50_13560	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IPM50_13565	COG0047	phosphoribosylformylglycinamidine synthase activity
IPM50_13575	COG0586	Pfam SNARE associated Golgi protein
IPM50_13585	COG1940	carbohydrate kinase activity
IPM50_13595	COG0437	4 iron, 4 sulfur cluster binding
IPM50_13630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IPM50_13635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IPM50_13655	COG1136	(ABC) transporter
IPM50_13665	COG0535	radical SAM domain protein
IPM50_13685	COG0469	pyruvate kinase activity
IPM50_13695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM50_13705	COG1253	flavin adenine dinucleotide binding
IPM50_13725	COG0148	phosphopyruvate hydratase activity
IPM50_13730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IPM50_13760	COG0322	excinuclease ABC activity
IPM50_13765	COG0009	L-threonylcarbamoyladenylate synthase
IPM50_13770	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IPM50_13780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM50_13795	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IPM50_13800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPM50_13810	COG3591	Belongs to the peptidase S1B family
IPM50_13815	COG0739	heme binding
IPM50_13835	COG1595	DNA-templated transcription, initiation
IPM50_13840	COG0640	Transcriptional regulator
IPM50_13845	COG0346	lactoylglutathione lyase activity
IPM50_13855	COG0798	PFAM Bile acid sodium symporter
IPM50_13860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IPM50_13870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPM50_13875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPM50_13880	COG1388	LysM domain
IPM50_13880	COG0741	lytic transglycosylase activity
IPM50_13885	COG1959	2 iron, 2 sulfur cluster binding
IPM50_13900	COG3118	belongs to the thioredoxin family
IPM50_13915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IPM50_13965	COG0515	serine threonine protein kinase
IPM50_13965	COG2815	serine threonine protein kinase
IPM50_14010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPM50_14025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IPM50_14030	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IPM50_14035	COG0799	negative regulation of ribosome biogenesis
IPM50_14040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IPM50_14045	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IPM50_14055	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IPM50_14060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IPM50_14070	COG0698	ribose 5-phosphate isomerase
IPM50_14085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IPM50_14110	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IPM50_14155	COG1722	exodeoxyribonuclease VII activity
IPM50_14165	COG1570	exodeoxyribonuclease VII activity
IPM50_14180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPM50_14225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IPM50_14230	COG0049	tRNA binding
IPM50_14235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPM50_14240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPM50_14245	COG0051	transcription antitermination factor activity, RNA binding
IPM50_14250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPM50_14255	COG0088	Forms part of the polypeptide exit tunnel
IPM50_14260	COG0089	rRNA binding
IPM50_14265	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPM50_14270	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPM50_14275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPM50_14280	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IPM50_14285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPM50_14290	COG0255	Belongs to the universal ribosomal protein uL29 family
IPM50_14295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IPM50_14300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPM50_14305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IPM50_14310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPM50_14315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IPM50_14320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPM50_14325	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IPM50_14330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IPM50_14335	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPM50_14345	COG0200	Binds to the 23S rRNA
IPM50_14355	COG0563	adenylate kinase activity
IPM50_14360	COG0024	Methionine aminopeptidase
IPM50_14365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPM50_14370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPM50_14375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPM50_14380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPM50_14385	COG0202	RNA polymerase activity
IPM50_14390	COG0203	ribosomal protein L17
IPM50_14395	COG0511	ligase activity, forming carbon-carbon bonds
IPM50_14400	COG0439	Biotin carboxylase
IPM50_14405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IPM50_14410	COG1185	polyribonucleotide nucleotidyltransferase activity
IPM50_14425	COG0423	glycine-tRNA ligase activity
IPM50_14435	COG1288	antiporter activity
IPM50_14460	COG0305	Participates in initiation and elongation during chromosome replication
IPM50_14460	COG0358	DNA primase activity
IPM50_14470	COG3011	Protein conserved in bacteria
IPM50_14475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IPM50_14480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM50_14485	COG1228	amidohydrolase
IPM50_14495	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPM50_14500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IPM50_14510	COG1131	(ABC) transporter
IPM50_14530	COG2165	general secretion pathway protein
IPM50_14535	COG2204	response regulator
IPM50_14540	COG5002	protein histidine kinase activity
IPM50_14550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IPM50_14585	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IPM50_14590	COG1518	maintenance of DNA repeat elements
IPM50_14600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IPM50_14605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPM50_14610	COG1505	serine-type exopeptidase activity
IPM50_14620	COG1104	cysteine desulfurase activity
IPM50_14635	COG1028	Short-chain dehydrogenase reductase Sdr
IPM50_14655	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IPM50_14665	COG0564	pseudouridine synthase activity
IPM50_14670	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IPM50_14675	COG0861	Integral membrane protein TerC family
IPM50_14685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM50_14690	COG0540	Belongs to the ATCase OTCase family
IPM50_14695	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IPM50_14700	COG0167	dihydroorotate dehydrogenase activity
IPM50_14710	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IPM50_14715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IPM50_14720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IPM50_14725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPM50_14730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPM50_14740	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IPM50_14745	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IPM50_14755	COG3710	Transcriptional regulator
IPM50_14775	COG1331	Highly conserved protein containing a thioredoxin domain
IPM50_14795	COG0515	serine threonine protein kinase
IPM50_14795	COG2815	serine threonine protein kinase
IPM50_14810	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IPM50_14820	COG1136	(ABC) transporter
IPM50_14820	COG0577	efflux transmembrane transporter activity
IPM50_14825	COG1136	(ABC) transporter
IPM50_14825	COG0577	efflux transmembrane transporter activity
IPM50_14835	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IPM50_14855	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM50_14865	COG2208	phosphoserine phosphatase activity
IPM50_14865	COG2770	Histidine kinase
IPM50_14885	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IPM50_14890	COG0504	CTP synthase activity
IPM50_14895	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IPM50_14905	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IPM50_14945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPM50_14970	COG0284	orotidine-5'-phosphate decarboxylase activity
IPM50_14985	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IPM50_14985	COG1918	ferrous iron import across plasma membrane
IPM50_14995	COG0521	Mo-molybdopterin cofactor biosynthetic process
IPM50_15005	COG1228	amidohydrolase
IPM50_15010	COG1228	amidohydrolase
IPM50_15020	COG1028	Short-chain dehydrogenase reductase Sdr
IPM50_15065	COG0151	Belongs to the GarS family
IPM50_15080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IPM50_15085	COG0697	spore germination
IPM50_15090	COG0742	ribosomal rna small subunit methyltransferase
IPM50_15095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IPM50_15100	COG0268	Binds directly to 16S ribosomal RNA
IPM50_15105	COG0484	heat shock protein binding
IPM50_15110	COG0848	biopolymer transport protein
IPM50_15115	COG0512	Glutamine amidotransferase of anthranilate synthase
IPM50_15115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IPM50_15120	COG0531	amino acid
IPM50_15130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IPM50_15145	COG0544	peptidyl-prolyl cis-trans isomerase activity
IPM50_15150	COG0740	serine-type endopeptidase activity
IPM50_15155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IPM50_15160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPM50_15165	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IPM50_15170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IPM50_15175	COG0297	glycogen (starch) synthase activity
IPM50_15180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IPM50_15285	COG2801	Transposase and inactivated derivatives
IPM50_15295	COG0629	single-stranded DNA binding
IPM50_15320	COG0328	RNA-DNA hybrid ribonuclease activity