locus-tag	class	description
IPM63_00030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IPM63_00045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IPM63_00100	COG0793	Belongs to the peptidase S41A family
IPM63_00100	COG3409	Peptidoglycan-binding domain 1 protein
IPM63_00125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IPM63_00125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPM63_00170	COG2815	serine threonine protein kinase
IPM63_00170	COG0515	serine threonine protein kinase
IPM63_00185	COG1942	4-Oxalocrotonate Tautomerase
IPM63_00220	COG3604	Transcriptional regulator
IPM63_00230	COG0515	serine threonine protein kinase
IPM63_00230	COG2815	serine threonine protein kinase
IPM63_00235	COG0204	Acyl-transferase
IPM63_00260	COG2255	four-way junction helicase activity
IPM63_00270	COG0632	four-way junction helicase activity
IPM63_00275	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IPM63_00285	COG0235	Class ii aldolase
IPM63_00295	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IPM63_00325	COG1704	LemA family
IPM63_00345	COG0275	rRNA processing
IPM63_00355	COG0768	penicillin binding
IPM63_00360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPM63_00365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM63_00370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPM63_00375	COG0772	Belongs to the SEDS family
IPM63_00380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPM63_00385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPM63_00390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IPM63_00400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPM63_00405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IPM63_00420	COG0525	valine-tRNA ligase activity
IPM63_00435	COG5000	phosphorelay sensor kinase activity
IPM63_00460	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPM63_00465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IPM63_00475	COG1131	(ABC) transporter
IPM63_00495	COG2165	general secretion pathway protein
IPM63_00500	COG2204	response regulator
IPM63_00505	COG3852	Histidine kinase
IPM63_00515	COG3547	Transposase (IS116 IS110 IS902 family)
IPM63_00525	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IPM63_00530	COG0859	PFAM glycosyl transferase family 9
IPM63_00535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IPM63_00540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IPM63_00550	COG1505	serine-type exopeptidase activity
IPM63_00560	COG0745	RESPONSE REGULATOR receiver
IPM63_00575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPM63_00585	COG4968	Prepilin-type N-terminal cleavage methylation domain
IPM63_00595	COG1028	Short-chain dehydrogenase reductase Sdr
IPM63_00685	COG2373	Large extracellular alpha-helical protein
IPM63_00695	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IPM63_00695	COG0517	IMP dehydrogenase activity
IPM63_00700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IPM63_00700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IPM63_00730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IPM63_00735	COG4221	oxidoreductase activity
IPM63_00740	COG4956	integral membrane protein (PIN domain superfamily)
IPM63_00745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IPM63_00750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IPM63_00750	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IPM63_00760	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IPM63_00765	COG1744	ABC transporter substrate-binding protein PnrA-like
IPM63_00775	COG3845	ABC transporter
IPM63_00780	COG0436	Aminotransferase
IPM63_00785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IPM63_00810	COG0318	PFAM AMP-dependent synthetase and ligase
IPM63_00830	COG0154	amidase activity
IPM63_00855	COG0531	amino acid
IPM63_00860	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IPM63_00870	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IPM63_00870	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IPM63_00875	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IPM63_00895	COG0495	leucyl-tRNA aminoacylation
IPM63_00900	COG2815	serine threonine protein kinase
IPM63_00900	COG0515	serine threonine protein kinase
IPM63_00905	COG1716	ATPase activity
IPM63_00905	COG0842	Transport permease protein
IPM63_00905	COG1131	(ABC) transporter
IPM63_00910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM63_00935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPM63_00960	COG1252	NADH dehydrogenase
IPM63_00975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IPM63_00985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IPM63_01010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IPM63_01015	COG1028	Short-chain dehydrogenase reductase Sdr
IPM63_01030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IPM63_01035	COG0564	pseudouridine synthase activity
IPM63_01055	COG0861	Integral membrane protein TerC family
IPM63_01065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM63_01070	COG0540	Belongs to the ATCase OTCase family
IPM63_01075	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IPM63_01080	COG0167	dihydroorotate dehydrogenase activity
IPM63_01090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IPM63_01095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IPM63_01100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IPM63_01105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPM63_01110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPM63_01120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IPM63_01125	COG2267	carboxylic ester hydrolase activity
IPM63_01145	COG0745	RESPONSE REGULATOR receiver
IPM63_01155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IPM63_01160	COG1331	Highly conserved protein containing a thioredoxin domain
IPM63_01180	COG0515	serine threonine protein kinase
IPM63_01185	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IPM63_01190	COG3608	succinylglutamate desuccinylase aspartoacylase
IPM63_01195	COG0189	ligase activity
IPM63_01205	COG0577	efflux transmembrane transporter activity
IPM63_01205	COG1136	(ABC) transporter
IPM63_01220	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IPM63_01240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM63_01250	COG2208	phosphoserine phosphatase activity
IPM63_01270	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IPM63_01280	COG0504	CTP synthase activity
IPM63_01295	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IPM63_01305	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IPM63_01340	COG1228	amidohydrolase
IPM63_01345	COG1305	Transglutaminase-like
IPM63_01350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPM63_01370	COG0598	Magnesium transport protein CorA
IPM63_01380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPM63_01410	COG4152	abc transporter atp-binding protein
IPM63_01415	COG1668	transmembrane transport
IPM63_01480	COG0745	RESPONSE REGULATOR receiver
IPM63_01515	COG0459	protein refolding
IPM63_01520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPM63_01525	COG0633	Ferredoxin
IPM63_01525	COG3217	Mosc domain protein beta barrel domain protein
IPM63_01535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IPM63_01545	COG0556	nucleotide-excision repair
IPM63_01550	COG0277	FAD linked oxidase domain protein
IPM63_01575	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IPM63_01580	COG0659	secondary active sulfate transmembrane transporter activity
IPM63_01605	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM63_01625	COG1690	Belongs to the RtcB family
IPM63_01645	COG4221	oxidoreductase activity
IPM63_01655	COG1696	Membrane protein involved in D-alanine export
IPM63_01695	COG1216	Glycosyl transferase, family 2
IPM63_01725	COG1233	COG1233 Phytoene dehydrogenase and related
IPM63_01735	COG0438	transferase activity, transferring glycosyl groups
IPM63_01745	COG0726	polysaccharide deacetylase
IPM63_01750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IPM63_01770	COG0022	dehydrogenase e1 component
IPM63_01770	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM63_01775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IPM63_01795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPM63_01805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPM63_01810	COG0509	glycine decarboxylation via glycine cleavage system
IPM63_01820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IPM63_01840	COG1606	tRNA processing
IPM63_01855	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IPM63_01860	COG5016	pyruvate
IPM63_01860	COG0511	ligase activity, forming carbon-carbon bonds
IPM63_01865	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IPM63_01875	COG0450	alkyl hydroperoxide reductase
IPM63_01885	COG0363	glucosamine-6-phosphate deaminase activity
IPM63_01890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IPM63_01895	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPM63_01905	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IPM63_01910	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IPM63_01925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IPM63_01930	COG0742	ribosomal rna small subunit methyltransferase
IPM63_01935	COG0697	spore germination
IPM63_01940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IPM63_01945	COG0037	tRNA processing
IPM63_01950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPM63_01960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IPM63_01985	COG0268	Binds directly to 16S ribosomal RNA
IPM63_01995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IPM63_02000	COG0531	amino acid
IPM63_02010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IPM63_02025	COG0544	peptidyl-prolyl cis-trans isomerase activity
IPM63_02030	COG0740	serine-type endopeptidase activity
IPM63_02035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IPM63_02040	COG0405	Gamma-glutamyltransferase
IPM63_02055	COG2815	serine threonine protein kinase
IPM63_02055	COG0515	serine threonine protein kinase
IPM63_02075	COG0631	protein serine/threonine phosphatase activity
IPM63_02080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPM63_02090	COG1490	D-aminoacyl-tRNA deacylase activity
IPM63_02095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPM63_02100	COG0561	phosphatase activity
IPM63_02105	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IPM63_02110	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IPM63_02115	COG0386	Belongs to the glutathione peroxidase family
IPM63_02125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPM63_02130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPM63_02135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IPM63_02140	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IPM63_02145	COG0297	glycogen (starch) synthase activity
IPM63_02150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IPM63_02185	COG1573	uracil-dna glycosylase
IPM63_02190	COG1757	Na H antiporter
IPM63_02195	COG0626	cystathionine gamma-synthase activity
IPM63_02210	COG1832	CoA-binding protein
IPM63_02215	COG0521	Mo-molybdopterin cofactor biosynthetic process
IPM63_02225	COG1228	amidohydrolase
IPM63_02230	COG1228	amidohydrolase
IPM63_02235	COG5002	protein histidine kinase activity
IPM63_02260	COG1028	Short-chain dehydrogenase reductase Sdr
IPM63_02300	COG0151	Belongs to the GarS family
IPM63_02315	COG4771	TonB-dependent receptor
IPM63_02330	COG0792	nuclease activity
IPM63_02345	COG0242	peptide deformylase activity
IPM63_02350	COG1012	belongs to the aldehyde dehydrogenase family
IPM63_02360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPM63_02365	COG1054	Belongs to the UPF0176 family
IPM63_02370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IPM63_02370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPM63_02380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IPM63_02405	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IPM63_02420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IPM63_02425	COG0193	aminoacyl-tRNA hydrolase activity
IPM63_02430	COG0360	Binds together with S18 to 16S ribosomal RNA
IPM63_02440	COG0359	binds to the 23S rRNA
IPM63_02445	COG0305	Participates in initiation and elongation during chromosome replication
IPM63_02450	COG2318	DinB family
IPM63_02455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IPM63_02470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IPM63_02475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IPM63_02490	COG1595	DNA-templated transcription, initiation
IPM63_02520	COG2815	serine threonine protein kinase
IPM63_02520	COG0515	serine threonine protein kinase
IPM63_02530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPM63_02535	COG1295	ribonuclease BN
IPM63_02570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPM63_02595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_02605	COG0640	Transcriptional regulator
IPM63_02630	COG2814	Major facilitator Superfamily
IPM63_02665	COG1012	belongs to the aldehyde dehydrogenase family
IPM63_02675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPM63_02680	COG0793	Belongs to the peptidase S41A family
IPM63_02680	COG3409	Peptidoglycan-binding domain 1 protein
IPM63_02695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IPM63_02700	COG1333	cytochrome c biogenesis protein
IPM63_02705	COG0109	protoheme IX farnesyltransferase activity
IPM63_02710	COG1845	cytochrome c oxidase, subunit III
IPM63_02715	COG2322	membrane
IPM63_02735	COG0793	Belongs to the peptidase S41A family
IPM63_02740	COG0444	Belongs to the ABC transporter superfamily
IPM63_02745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPM63_02760	COG0577	efflux transmembrane transporter activity
IPM63_02760	COG1136	(ABC) transporter
IPM63_02765	COG0577	efflux transmembrane transporter activity
IPM63_02765	COG1136	(ABC) transporter
IPM63_02780	COG1136	(ABC) transporter
IPM63_02790	COG1716	ATPase activity
IPM63_02795	COG2815	serine threonine protein kinase
IPM63_02795	COG0515	serine threonine protein kinase
IPM63_02805	COG2208	phosphoserine phosphatase activity
IPM63_02805	COG2770	Histidine kinase
IPM63_02810	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IPM63_02810	COG2199	diguanylate cyclase activity
IPM63_02820	COG0552	protein localization to endoplasmic reticulum
IPM63_02825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IPM63_02825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IPM63_02830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPM63_02855	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IPM63_02870	COG0300	oxidoreductase activity
IPM63_02875	COG1968	undecaprenyl-diphosphatase activity
IPM63_02880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IPM63_02880	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IPM63_02890	COG1137	ATPase activity
IPM63_02900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IPM63_02905	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IPM63_02920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPM63_02925	COG0010	Belongs to the arginase family
IPM63_02930	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPM63_02955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IPM63_02970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IPM63_02980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPM63_02985	COG3557	Belongs to the UPF0374 family
IPM63_02990	COG2267	carboxylic ester hydrolase activity
IPM63_02995	COG0589	response to stress
IPM63_03030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPM63_03035	COG0179	Fumarylacetoacetate (FAA) hydrolase
IPM63_03045	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IPM63_03050	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IPM63_03055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IPM63_03060	COG3876	Protein conserved in bacteria
IPM63_03075	COG1381	Involved in DNA repair and RecF pathway recombination
IPM63_03085	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IPM63_03090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IPM63_03100	COG1475	DNA binding
IPM63_03105	COG1192	Involved in chromosome partitioning
IPM63_03125	COG0825	malonyl-CoA metabolic process
IPM63_03130	COG0629	single-stranded DNA binding
IPM63_03150	COG1214	PFAM Peptidase M22, glycoprotease
IPM63_03175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM63_03180	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IPM63_03205	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPM63_03205	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPM63_03210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IPM63_03225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPM63_03240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM63_03245	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IPM63_03255	COG0489	protein tyrosine kinase activity
IPM63_03260	COG1596	polysaccharide export
IPM63_03265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IPM63_03270	COG1472	Belongs to the glycosyl hydrolase 3 family
IPM63_03290	COG1271	oxidase subunit
IPM63_03295	COG1294	oxidase, subunit
IPM63_03315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPM63_03320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IPM63_03330	COG0463	Glycosyl transferase, family 2
IPM63_03335	COG2226	methyltransferase
IPM63_03340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM63_03390	COG0367	asparagine synthase
IPM63_03390	COG0367	asparagine synthase
IPM63_03405	COG1215	transferase activity, transferring glycosyl groups
IPM63_03415	COG0438	transferase activity, transferring glycosyl groups
IPM63_03425	COG0438	transferase activity, transferring glycosyl groups
IPM63_03450	COG0367	asparagine synthase
IPM63_03465	COG0367	asparagine synthase
IPM63_03470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPM63_03480	COG2755	lipolytic protein G-D-S-L family
IPM63_03480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPM63_03505	COG1083	cytidylyl-transferase
IPM63_03510	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IPM63_03520	COG2089	acid synthase
IPM63_03530	COG1596	polysaccharide export
IPM63_03540	COG2197	response regulator
IPM63_03545	COG2197	response regulator
IPM63_03585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM63_03650	COG2270	Major facilitator Superfamily
IPM63_03655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IPM63_03665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPM63_03675	COG0017	Asparaginyl-tRNA synthetase
IPM63_03705	COG0612	Peptidase, M16
IPM63_03710	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPM63_03720	COG0183	Belongs to the thiolase family
IPM63_03745	COG0442	prolyl-tRNA aminoacylation
IPM63_03760	COG0142	geranyltranstransferase activity
IPM63_03770	COG0084	hydrolase, TatD family'
IPM63_03775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM63_03775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM63_03785	COG0302	gtp cyclohydrolase
IPM63_03790	COG0135	phosphoribosylanthranilate isomerase activity
IPM63_03795	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IPM63_03815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IPM63_03820	COG0018	arginyl-trna synthetase
IPM63_03830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IPM63_03835	COG0134	indole-3-glycerol-phosphate synthase activity
IPM63_03840	COG0133	tryptophan synthase activity
IPM63_03845	COG0159	tryptophan synthase activity
IPM63_03850	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IPM63_03885	COG0612	Peptidase, M16
IPM63_03895	COG1404	Belongs to the peptidase S8 family
IPM63_03905	COG0793	Belongs to the peptidase S41A family
IPM63_03915	COG2304	oxidoreductase activity
IPM63_03925	COG3842	ATPase activity
IPM63_03930	COG2885	chlorophyll binding
IPM63_03935	COG1132	(ABC) transporter
IPM63_03940	COG1561	YicC-like family, N-terminal region
IPM63_03945	COG1758	RNA polymerase activity
IPM63_04020	COG0045	succinate-CoA ligase (ADP-forming) activity
IPM63_04035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPM63_04040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPM63_04055	COG0824	Thioesterase
IPM63_04060	COG2986	histidine ammonia-lyase
IPM63_04065	COG0668	transmembrane transport
IPM63_04070	COG1228	amidohydrolase
IPM63_04095	COG0833	amino acid
IPM63_04115	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IPM63_04145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IPM63_04150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPM63_04155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IPM63_04160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IPM63_04165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IPM63_04170	COG0784	Response regulator, receiver
IPM63_04170	COG2205	protein histidine kinase activity
IPM63_04170	COG5002	protein histidine kinase activity
IPM63_04175	COG0072	phenylalanine-tRNA ligase activity
IPM63_04195	COG1692	metallophosphoesterase
IPM63_04220	COG0673	inositol 2-dehydrogenase activity
IPM63_04225	COG1082	Xylose isomerase domain protein TIM barrel
IPM63_04260	COG4585	Histidine kinase
IPM63_04300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IPM63_04310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPM63_04325	COG2226	methyltransferase
IPM63_04330	COG0601	transmembrane transport
IPM63_04335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPM63_04340	COG0617	tRNA 3'-terminal CCA addition
IPM63_04340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IPM63_04340	COG3620	sequence-specific DNA binding
IPM63_04350	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IPM63_04355	COG1984	allophanate hydrolase subunit 2
IPM63_04365	COG1914	H( )-stimulated, divalent metal cation uptake system
IPM63_04370	COG0071	Belongs to the small heat shock protein (HSP20) family
IPM63_04420	COG3279	Response regulator of the LytR AlgR family
IPM63_04425	COG3275	phosphorelay sensor kinase activity
IPM63_04430	COG0702	epimerase
IPM63_04435	COG3158	transport of potassium into the cell
IPM63_04440	COG2205	protein histidine kinase activity
IPM63_04455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_04475	COG1522	sequence-specific DNA binding
IPM63_04515	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IPM63_04540	COG0732	type I restriction modification DNA specificity domain
IPM63_04545	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IPM63_04555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_04565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_04570	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IPM63_04575	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IPM63_04580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_04590	COG4946	Tricorn protease homolog
IPM63_04590	COG0793	Belongs to the peptidase S41A family
IPM63_04610	COG4948	Mandelate Racemase Muconate Lactonizing
IPM63_04635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IPM63_04640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPM63_04645	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPM63_04655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPM63_04665	COG2217	Heavy metal translocating P-type atpase
IPM63_04695	COG0284	orotidine-5'-phosphate decarboxylase activity
IPM63_04755	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IPM63_04820	COG0215	cysteine-tRNA ligase activity
IPM63_04840	COG0745	RESPONSE REGULATOR receiver
IPM63_04845	COG0577	efflux transmembrane transporter activity
IPM63_04850	COG0006	proline dipeptidase activity
IPM63_04870	COG1410	methionine synthase
IPM63_04870	COG0646	methionine synthase
IPM63_04915	COG1597	lipid kinase activity
IPM63_04920	COG1022	Amp-dependent synthetase and ligase
IPM63_04930	COG2205	protein histidine kinase activity
IPM63_04935	COG0745	RESPONSE REGULATOR receiver
IPM63_04940	COG3678	ATP-independent chaperone mediated protein folding
IPM63_04955	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPM63_04965	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPM63_04975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IPM63_04980	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IPM63_04990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IPM63_04995	COG2204	response regulator
IPM63_05005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM63_05005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM63_05025	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM63_05025	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM63_05040	COG1051	belongs to the nudix hydrolase family
IPM63_05050	COG0596	Alpha beta hydrolase
IPM63_05055	COG1024	Enoyl-CoA hydratase
IPM63_05115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPM63_05130	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IPM63_05150	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IPM63_05160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPM63_05175	COG1058	Belongs to the CinA family
IPM63_05175	COG1546	Belongs to the CinA family
IPM63_05220	COG1480	7TM receptor with intracellular HD hydrolase
IPM63_05235	COG0776	regulation of translation
IPM63_05245	COG0384	phenazine biosynthesis protein PhzF
IPM63_05255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IPM63_05270	COG0745	RESPONSE REGULATOR receiver
IPM63_05275	COG5002	protein histidine kinase activity
IPM63_05310	COG0492	ferredoxin-NADP+ reductase activity
IPM63_05320	COG0354	folic acid binding
IPM63_05330	COG0489	protein tyrosine kinase activity
IPM63_05335	COG0316	Belongs to the HesB IscA family
IPM63_05355	COG4770	biotin carboxylase activity
IPM63_05375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPM63_05380	COG0205	6-phosphofructokinase activity
IPM63_05385	COG0793	Belongs to the peptidase S41A family
IPM63_05400	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IPM63_05415	COG0243	molybdopterin cofactor binding
IPM63_05425	COG1404	Belongs to the peptidase S8 family
IPM63_05430	COG0493	'glutamate synthase
IPM63_05435	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPM63_05435	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPM63_05440	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPM63_05445	COG3547	Transposase (IS116 IS110 IS902 family)
IPM63_05450	COG1136	(ABC) transporter
IPM63_05465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPM63_05480	COG0588	phosphoglycerate mutase activity
IPM63_05490	COG0285	dihydrofolate synthase activity
IPM63_05500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IPM63_05505	COG0483	inositol monophosphate 1-phosphatase activity
IPM63_05525	COG0590	tRNA wobble adenosine to inosine editing
IPM63_05550	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPM63_05560	COG0688	phosphatidylethanolamine metabolic process
IPM63_05565	COG1183	phosphatidylcholine synthase activity
IPM63_05580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IPM63_05600	COG3547	Transposase (IS116 IS110 IS902 family)
IPM63_05605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IPM63_05610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IPM63_05615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IPM63_05620	COG0195	Participates in both transcription termination and antitermination
IPM63_05625	COG0779	Required for maturation of 30S ribosomal subunits
IPM63_05635	COG1940	carbohydrate kinase activity
IPM63_05655	COG1129	ABC transporter
IPM63_05665	COG1640	4-alpha-glucanotransferase
IPM63_05685	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IPM63_05700	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IPM63_05705	COG0058	SHG alpha-glucan phosphorylase activity
IPM63_05735	COG1446	asparaginase
IPM63_05745	COG1562	ergosterol biosynthetic process
IPM63_05750	COG0142	geranyltranstransferase activity
IPM63_05760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IPM63_05765	COG1573	uracil-dna glycosylase
IPM63_05770	COG0494	nUDIX hydrolase
IPM63_05775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPM63_05780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IPM63_05785	COG0052	Belongs to the universal ribosomal protein uS2 family
IPM63_05790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IPM63_05795	COG0528	UMP kinase activity
IPM63_05800	COG0233	cytoplasmic translational termination
IPM63_05825	COG1595	DNA-templated transcription, initiation
IPM63_05850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPM63_05875	COG1454	alcohol dehydrogenase
IPM63_05875	COG1012	belongs to the aldehyde dehydrogenase family
IPM63_05890	COG0517	IMP dehydrogenase activity
IPM63_05890	COG0516	GMP reductase activity
IPM63_05900	COG1132	(ABC) transporter
IPM63_05905	COG0488	(ABC) transporter
IPM63_05915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IPM63_05935	COG0848	biopolymer transport protein
IPM63_05940	COG0848	biopolymer transport protein
IPM63_05955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM63_05960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM63_05965	COG1862	Preprotein translocase
IPM63_05970	COG0343	queuine tRNA-ribosyltransferase activity
IPM63_05980	COG1160	GTP binding
IPM63_06005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IPM63_06010	COG1254	Belongs to the acylphosphatase family
IPM63_06020	COG0351	phosphomethylpyrimidine kinase
IPM63_06020	COG0352	thiamine-phosphate diphosphorylase activity
IPM63_06025	COG0352	thiamine-phosphate diphosphorylase activity
IPM63_06040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPM63_06045	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPM63_06050	COG0646	methionine synthase
IPM63_06050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IPM63_06080	COG3655	Transcriptional regulator
IPM63_06085	COG1032	radical SAM domain protein
IPM63_06095	COG3321	synthase
IPM63_06095	COG1028	Short-chain dehydrogenase reductase Sdr
IPM63_06095	COG0604	alcohol dehydrogenase
IPM63_06105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IPM63_06120	COG0667	Aldo Keto reductase
IPM63_06135	COG1063	alcohol dehydrogenase
IPM63_06145	COG1959	2 iron, 2 sulfur cluster binding
IPM63_06150	COG1090	epimerase
IPM63_06155	COG2010	Cytochrome c
IPM63_06160	COG2022	thiamine diphosphate biosynthetic process
IPM63_06175	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM63_06180	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM63_06185	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM63_06190	COG0649	NAD binding
IPM63_06230	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IPM63_06235	COG0839	Belongs to the complex I subunit 6 family
IPM63_06240	COG0713	ATP synthesis coupled electron transport
IPM63_06255	COG1007	ATP synthesis coupled electron transport
IPM63_06270	COG0512	Glutamine amidotransferase of anthranilate synthase
IPM63_06270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IPM63_06300	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IPM63_06305	COG0626	cystathionine gamma-synthase activity
IPM63_06310	COG0631	protein serine/threonine phosphatase activity
IPM63_06375	COG4946	Tricorn protease homolog
IPM63_06375	COG1506	peptidase
IPM63_06375	COG0823	Involved in the tonB-independent uptake of proteins
IPM63_06400	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IPM63_06405	COG0542	response to heat
IPM63_06420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IPM63_06425	COG1053	succinate dehydrogenase
IPM63_06435	COG0583	DNA-binding transcription factor activity
IPM63_06440	COG2199	diguanylate cyclase activity
IPM63_06440	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IPM63_06460	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IPM63_06465	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IPM63_06470	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IPM63_06475	COG0698	ribose 5-phosphate isomerase
IPM63_06495	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IPM63_06520	COG0730	response to heat
IPM63_06535	COG1247	-acetyltransferase
IPM63_06565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPM63_06585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM63_06595	COG1691	(AIR) carboxylase
IPM63_06600	COG0163	prenyltransferase activity
IPM63_06610	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IPM63_06630	COG2385	sporulation resulting in formation of a cellular spore
IPM63_06630	COG2385	sporulation resulting in formation of a cellular spore
IPM63_06635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IPM63_06640	COG1923	regulation of RNA biosynthetic process
IPM63_06645	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IPM63_06650	COG0470	DNA polymerase III
IPM63_06670	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IPM63_06675	COG0750	zinc metalloprotease
IPM63_06690	COG1595	DNA-templated transcription, initiation
IPM63_06710	COG0717	Belongs to the dCTP deaminase family
IPM63_06735	COG0662	Cupin 2, conserved barrel domain protein
IPM63_06750	COG3844	kynureninase activity
IPM63_06755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IPM63_06775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPM63_06785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPM63_06795	COG1595	DNA-templated transcription, initiation
IPM63_06815	COG0739	heme binding
IPM63_06825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPM63_06835	COG0123	including yeast histone deacetylase and acetoin utilization protein
IPM63_06845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPM63_06860	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IPM63_06865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IPM63_06870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IPM63_06875	COG0586	Pfam SNARE associated Golgi protein
IPM63_06885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IPM63_06900	COG4447	cellulose binding
IPM63_06915	COG0612	Peptidase, M16
IPM63_06920	COG0720	synthase
IPM63_06925	COG1199	ATP-dependent helicase activity
IPM63_06940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IPM63_07000	COG1960	acyl-CoA dehydrogenase activity
IPM63_07005	COG0166	Belongs to the GPI family
IPM63_07010	COG2169	Transcriptional regulator
IPM63_07010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IPM63_07020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IPM63_07030	COG1028	Short-chain dehydrogenase reductase Sdr
IPM63_07055	COG1663	tetraacyldisaccharide 4'-kinase activity
IPM63_07065	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPM63_07070	COG0356	it plays a direct role in the translocation of protons across the membrane
IPM63_07090	COG1519	Transferase
IPM63_07095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPM63_07105	COG0574	Belongs to the PEP-utilizing enzyme family
IPM63_07105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPM63_07115	COG1819	glycosyl
IPM63_07130	COG2204	response regulator
IPM63_07135	COG4191	Histidine kinase
IPM63_07150	COG0571	ribonuclease III activity
IPM63_07155	COG0681	Belongs to the peptidase S26 family
IPM63_07160	COG2313	pseudouridylate synthase activity
IPM63_07170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPM63_07175	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IPM63_07190	COG1960	acyl-CoA dehydrogenase activity
IPM63_07200	COG1247	-acetyltransferase
IPM63_07215	COG0022	dehydrogenase e1 component
IPM63_07230	COG0515	serine threonine protein kinase
IPM63_07230	COG2815	serine threonine protein kinase
IPM63_07275	COG1765	OsmC-like protein
IPM63_07290	COG0492	ferredoxin-NADP+ reductase activity
IPM63_07310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPM63_07315	COG3872	metal-dependent enzyme
IPM63_07320	COG0254	rRNA binding
IPM63_07330	COG0357	Ribosomal RNA small subunit methyltransferase G
IPM63_07340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IPM63_07350	COG0762	integral membrane protein
IPM63_07365	COG0217	transcriptional regulatory protein
IPM63_07370	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IPM63_07375	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM63_07375	COG0567	Dehydrogenase, E1 component
IPM63_07400	COG1196	nuclear chromosome segregation
IPM63_07415	COG0789	Transcriptional regulator
IPM63_07420	COG0484	heat shock protein binding
IPM63_07425	COG0443	Heat shock 70 kDa protein
IPM63_07435	COG1408	metallophosphoesterase
IPM63_07460	COG0471	metal ion transport
IPM63_07460	COG3273	potassium ion transport
IPM63_07475	COG3275	phosphorelay sensor kinase activity
IPM63_07505	COG0590	tRNA wobble adenosine to inosine editing
IPM63_07515	COG2382	esterase
IPM63_07525	COG0667	Aldo Keto reductase
IPM63_07530	COG1956	GAF domain-containing protein
IPM63_07545	COG1028	Short-chain dehydrogenase reductase Sdr
IPM63_07550	COG0577	efflux transmembrane transporter activity
IPM63_07550	COG1136	(ABC) transporter
IPM63_07555	COG1136	(ABC) transporter
IPM63_07590	COG0314	molybdopterin synthase activity
IPM63_07600	COG0318	PFAM AMP-dependent synthetase and ligase
IPM63_07605	COG1028	Short-chain dehydrogenase reductase Sdr
IPM63_07610	COG2815	serine threonine protein kinase
IPM63_07610	COG0515	serine threonine protein kinase
IPM63_07625	COG3275	phosphorelay sensor kinase activity
IPM63_07630	COG3279	Response regulator of the LytR AlgR family
IPM63_07645	COG0402	S-adenosylhomocysteine deaminase activity
IPM63_07650	COG0295	cytidine deaminase activity
IPM63_07660	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IPM63_07665	COG1079	Belongs to the binding-protein-dependent transport system permease family
IPM63_07670	COG4603	Belongs to the binding-protein-dependent transport system permease family
IPM63_07680	COG0542	response to heat
IPM63_07685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPM63_07690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IPM63_07735	COG2815	serine threonine protein kinase
IPM63_07735	COG0515	serine threonine protein kinase
IPM63_07755	COG1228	amidohydrolase
IPM63_07760	COG0515	serine threonine protein kinase
IPM63_07800	COG0322	excinuclease ABC activity
IPM63_07805	COG0009	L-threonylcarbamoyladenylate synthase
IPM63_07820	COG0419	ATPase involved in DNA repair
IPM63_07820	COG0419	ATPase involved in DNA repair
IPM63_07825	COG0328	RNA-DNA hybrid ribonuclease activity
IPM63_07840	COG2264	protein methyltransferase activity
IPM63_07845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IPM63_07865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM63_07870	COG1530	ribonuclease E activity
IPM63_07870	COG1530	ribonuclease E activity
IPM63_07885	COG0542	response to heat
IPM63_07895	COG0148	phosphopyruvate hydratase activity
IPM63_07905	COG1253	flavin adenine dinucleotide binding
IPM63_07915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM63_07935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPM63_07945	COG0346	lactoylglutathione lyase activity
IPM63_08010	COG0473	3-isopropylmalate dehydrogenase activity
IPM63_08050	COG0823	Involved in the tonB-independent uptake of proteins
IPM63_08060	COG3153	acetyltransferase
IPM63_08080	COG2264	protein methyltransferase activity
IPM63_08115	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IPM63_08160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM63_08160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM63_08185	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IPM63_08225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IPM63_08245	COG3549	Plasmid maintenance system killer
IPM63_08275	COG2095	MarC family integral membrane protein
IPM63_08290	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPM63_08295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IPM63_08310	COG1136	(ABC) transporter
IPM63_08330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IPM63_08335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IPM63_08370	COG0437	4 iron, 4 sulfur cluster binding
IPM63_08395	COG0047	phosphoribosylformylglycinamidine synthase activity
IPM63_08400	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IPM63_08415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IPM63_08430	COG0436	Aminotransferase
IPM63_08445	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPM63_08445	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPM63_08450	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPM63_08450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPM63_08475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPM63_08485	COG0823	Involved in the tonB-independent uptake of proteins
IPM63_08490	COG1228	amidohydrolase
IPM63_08500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IPM63_08505	COG2249	NAD(P)H dehydrogenase (quinone) activity
IPM63_08515	COG0124	histidyl-tRNA synthetase
IPM63_08530	COG0731	radical SAM domain protein
IPM63_08540	COG2204	response regulator
IPM63_08555	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IPM63_08570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPM63_08590	COG0589	response to stress
IPM63_08605	COG1022	Amp-dependent synthetase and ligase
IPM63_08610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPM63_08615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IPM63_08690	COG1960	acyl-CoA dehydrogenase activity
IPM63_08695	COG0183	Belongs to the thiolase family
IPM63_08705	COG0442	prolyl-tRNA aminoacylation
IPM63_08710	COG0519	Catalyzes the synthesis of GMP from XMP
IPM63_08730	COG1024	Enoyl-CoA hydratase
IPM63_08730	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPM63_08780	COG1228	amidohydrolase
IPM63_08790	COG1132	(ABC) transporter
IPM63_08805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM63_08805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM63_08835	COG1078	dGTPase activity
IPM63_08845	COG3590	peptidase
IPM63_08855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPM63_08860	COG0085	RNA polymerase activity
IPM63_08865	COG0222	ribosome binding
IPM63_08875	COG0081	regulation of translation
IPM63_08880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IPM63_08900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IPM63_08905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPM63_08925	COG4974	Belongs to the 'phage' integrase family
IPM63_08935	COG0644	oxidoreductase
IPM63_08970	COG2815	serine threonine protein kinase
IPM63_08970	COG0515	serine threonine protein kinase
IPM63_08975	COG0488	(ABC) transporter
IPM63_08980	COG4948	Mandelate Racemase Muconate Lactonizing
IPM63_08985	COG0668	transmembrane transport
IPM63_08995	COG0822	iron-sulfur transferase activity
IPM63_09005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPM63_09010	COG0719	Fe-S assembly protein
IPM63_09025	COG0396	ATPase activity
IPM63_09040	COG0251	oxidation-reduction process
IPM63_09050	COG0719	Fe-S assembly protein
IPM63_09090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPM63_09130	COG0823	Involved in the tonB-independent uptake of proteins
IPM63_09155	COG2094	Belongs to the DNA glycosylase MPG family
IPM63_09170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IPM63_09200	COG0686	Belongs to the AlaDH PNT family
IPM63_09210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM63_09215	COG1063	alcohol dehydrogenase
IPM63_09225	COG2205	protein histidine kinase activity
IPM63_09235	COG3720	iron ion transport
IPM63_09240	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IPM63_09245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IPM63_09250	COG4558	Periplasmic binding protein
IPM63_09265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPM63_09270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IPM63_09275	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IPM63_09285	COG1100	Small GTP-binding protein
IPM63_09290	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IPM63_09295	COG1064	alcohol dehydrogenase
IPM63_09300	COG2205	protein histidine kinase activity
IPM63_09305	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IPM63_09315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IPM63_09345	COG0142	geranyltranstransferase activity
IPM63_09385	COG3385	transposase activity
IPM63_09415	COG1297	OPT oligopeptide transporter protein
IPM63_09430	COG2268	Band 7 protein
IPM63_09440	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IPM63_09445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IPM63_09450	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IPM63_09460	COG0799	negative regulation of ribosome biogenesis
IPM63_09465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IPM63_09475	COG1040	competence protein
IPM63_09490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPM63_09500	COG0783	Belongs to the Dps family
IPM63_09505	COG2832	Protein of unknown function (DUF454)
IPM63_09510	COG1473	amidohydrolase
IPM63_09530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM63_09545	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IPM63_09550	COG0602	queuosine metabolic process
IPM63_09575	COG0006	proline dipeptidase activity
IPM63_09605	COG2226	methyltransferase
IPM63_09610	COG0584	glycerophosphoryl diester phosphodiesterase
IPM63_09750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPM63_09760	COG4977	sequence-specific DNA binding
IPM63_09770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPM63_09775	COG1090	epimerase
IPM63_09805	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
IPM63_09820	COG2267	carboxylic ester hydrolase activity
IPM63_09835	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IPM63_09840	COG0530	calcium, potassium:sodium antiporter activity
IPM63_09845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPM63_09855	COG0022	dehydrogenase e1 component
IPM63_09875	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM63_09895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPM63_09895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IPM63_09925	COG0723	plastoquinol--plastocyanin reductase activity
IPM63_09940	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IPM63_10065	COG3005	denitrification pathway
IPM63_10075	COG1333	cytochrome c biogenesis protein
IPM63_10085	COG0574	Belongs to the PEP-utilizing enzyme family
IPM63_10085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPM63_10110	COG3875	lactate racemase activity
IPM63_10140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPM63_10145	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IPM63_10150	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IPM63_10155	COG0708	Exodeoxyribonuclease III
IPM63_10160	COG0778	Nitroreductase
IPM63_10190	COG3104	oligopeptide transport
IPM63_10195	COG3104	oligopeptide transport
IPM63_10195	COG3104	oligopeptide transport
IPM63_10210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IPM63_10220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPM63_10230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IPM63_10235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IPM63_10245	COG1366	Belongs to the anti-sigma-factor antagonist family
IPM63_10270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM63_10275	COG0438	transferase activity, transferring glycosyl groups
IPM63_10290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IPM63_10295	COG0367	asparagine synthase
IPM63_10310	COG2192	nodulation
IPM63_10335	COG1215	transferase activity, transferring glycosyl groups
IPM63_10340	COG3551	Protein conserved in bacteria
IPM63_10355	COG3246	L-lysine catabolic process to acetate
IPM63_10380	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IPM63_10385	COG0529	Catalyzes the synthesis of activated sulfate
IPM63_10385	COG2046	Belongs to the sulfate adenylyltransferase family
IPM63_10405	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IPM63_10410	COG2133	pyrroloquinoline quinone binding
IPM63_10435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPM63_10440	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IPM63_10445	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IPM63_10450	COG0235	Class ii aldolase
IPM63_10460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IPM63_10485	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IPM63_10505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPM63_10510	COG1921	L-seryl-tRNASec selenium transferase activity
IPM63_10520	COG1278	Cold shock
IPM63_10525	COG3483	tryptophan 2,3-dioxygenase activity
IPM63_10530	COG0737	Belongs to the 5'-nucleotidase family
IPM63_10565	COG0481	GTPase activity
IPM63_10575	COG0515	serine threonine protein kinase
IPM63_10575	COG2815	serine threonine protein kinase
IPM63_10590	COG2815	serine threonine protein kinase
IPM63_10590	COG0515	serine threonine protein kinase
IPM63_10630	COG3963	phosphatidate phosphatase activity
IPM63_10635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPM63_10640	COG0758	DNA mediated transformation
IPM63_10660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPM63_10665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IPM63_10670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IPM63_10690	COG2835	tetraacyldisaccharide 4'-kinase activity
IPM63_10705	COG3273	potassium ion transport
IPM63_10705	COG0471	metal ion transport
IPM63_10725	COG0248	Ppx GppA phosphatase
IPM63_10735	COG0588	phosphoglycerate mutase activity
IPM63_10740	COG0745	RESPONSE REGULATOR receiver
IPM63_10745	COG5002	protein histidine kinase activity
IPM63_10755	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IPM63_10770	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IPM63_10775	COG3547	Transposase (IS116 IS110 IS902 family)
IPM63_10800	COG2321	neutral zinc metallopeptidase
IPM63_10815	COG0497	DNA recombination
IPM63_10830	COG2226	methyltransferase
IPM63_10855	COG0475	glutathione-regulated potassium exporter activity
IPM63_10865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPM63_10880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IPM63_10885	COG2267	carboxylic ester hydrolase activity
IPM63_10890	COG3738	Protein conserved in bacteria
IPM63_10905	COG2204	response regulator
IPM63_10915	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IPM63_10920	COG0542	response to heat
IPM63_10930	COG4935	Belongs to the peptidase S8 family
IPM63_10930	COG2234	aminopeptidase activity
IPM63_10940	COG4946	Tricorn protease homolog
IPM63_10940	COG0793	Belongs to the peptidase S41A family
IPM63_10975	COG0534	Mate efflux family protein
IPM63_10985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IPM63_10995	COG4895	conserved protein (DUF2196)
IPM63_11010	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IPM63_11020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_11025	COG3537	Alpha-1,2-mannosidase
IPM63_11045	COG0564	pseudouridine synthase activity
IPM63_11050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IPM63_11060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IPM63_11070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPM63_11100	COG0589	response to stress
IPM63_11115	COG0543	2 iron, 2 sulfur cluster binding
IPM63_11115	COG0493	'glutamate synthase
IPM63_11120	COG0489	protein tyrosine kinase activity
IPM63_11120	COG3206	protein involved in exopolysaccharide biosynthesis
IPM63_11135	COG0741	lytic transglycosylase activity
IPM63_11140	COG2239	Acts as a magnesium transporter
IPM63_11155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM63_11160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IPM63_11165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IPM63_11180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM63_11200	COG0724	RNA recognition motif
IPM63_11205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM63_11205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM63_11210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPM63_11245	COG0596	Alpha beta hydrolase
IPM63_11275	COG0352	thiamine-phosphate diphosphorylase activity
IPM63_11285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IPM63_11300	COG0745	RESPONSE REGULATOR receiver
IPM63_11315	COG0574	Belongs to the PEP-utilizing enzyme family
IPM63_11315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPM63_11320	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IPM63_11335	COG2205	protein histidine kinase activity
IPM63_11340	COG2199	diguanylate cyclase activity
IPM63_11340	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IPM63_11350	COG4221	oxidoreductase activity
IPM63_11355	COG1309	transcriptional regulator
IPM63_11360	COG3547	Transposase (IS116 IS110 IS902 family)
IPM63_11370	COG3956	TIGRFAM MazG family protein
IPM63_11385	COG0280	phosphate acetyltransferase
IPM63_11395	COG0321	lipoyl(octanoyl) transferase activity
IPM63_11395	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IPM63_11400	COG0196	riboflavin kinase activity
IPM63_11405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPM63_11430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IPM63_11460	COG3177	Filamentation induced by cAMP protein fic
IPM63_11505	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IPM63_11515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IPM63_11540	COG1252	NADH dehydrogenase
IPM63_11560	COG3604	Transcriptional regulator
IPM63_11570	COG0582	viral genome integration into host DNA
IPM63_11655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IPM63_11795	COG3386	PFAM SMP-30 Gluconolaconase
IPM63_11845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPM63_11865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IPM63_11885	COG0573	inorganic phosphate transmembrane transporter activity
IPM63_11890	COG0581	inorganic phosphate transmembrane transporter activity
IPM63_11895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IPM63_11900	COG0704	Plays a role in the regulation of phosphate uptake
IPM63_11905	COG0306	phosphate transporter
IPM63_11940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPM63_11945	COG0412	Dienelactone hydrolase
IPM63_11955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPM63_11960	COG1234	tRNA 3'-trailer cleavage
IPM63_11990	COG0367	asparagine synthase
IPM63_11995	COG0463	Glycosyl transferase, family 2
IPM63_12005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPM63_12015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPM63_12020	COG2835	tetraacyldisaccharide 4'-kinase activity
IPM63_12030	COG1028	Short-chain dehydrogenase reductase Sdr
IPM63_12035	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IPM63_12055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IPM63_12065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IPM63_12100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPM63_12115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IPM63_12115	COG0519	Catalyzes the synthesis of GMP from XMP
IPM63_12120	COG0471	metal ion transport
IPM63_12135	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IPM63_12175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPM63_12185	COG0805	protein transport
IPM63_12190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPM63_12200	COG1475	DNA binding
IPM63_12205	COG1192	Involved in chromosome partitioning
IPM63_12210	COG0445	tRNA wobble uridine modification
IPM63_12230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IPM63_12275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IPM63_12290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPM63_12305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IPM63_12310	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IPM63_12320	COG4399	Belongs to the UPF0754 family
IPM63_12340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPM63_12350	COG0592	DNA-directed DNA polymerase activity
IPM63_12370	COG0531	amino acid
IPM63_12375	COG2119	membrane
IPM63_12415	COG1652	LysM domain
IPM63_12420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IPM63_12445	COG0653	protein targeting
IPM63_12465	COG0438	transferase activity, transferring glycosyl groups
IPM63_12480	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IPM63_12500	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IPM63_12540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IPM63_12555	COG1131	(ABC) transporter
IPM63_12590	COG1022	Amp-dependent synthetase and ligase
IPM63_12595	COG1309	transcriptional regulator
IPM63_12610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPM63_12615	COG4221	oxidoreductase activity
IPM63_12630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPM63_12665	COG2154	pterin-4-alpha-carbinolamine dehydratase
IPM63_12680	COG0737	Belongs to the 5'-nucleotidase family
IPM63_12695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IPM63_12705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IPM63_12710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IPM63_12715	COG0463	Glycosyl transferase, family 2
IPM63_12730	COG3384	dioxygenase
IPM63_12735	COG4680	protein conserved in bacteria
IPM63_12780	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
IPM63_12795	COG2031	fatty acid transporter
IPM63_12815	COG0513	Belongs to the DEAD box helicase family
IPM63_12820	COG0724	RNA recognition motif
IPM63_12830	COG1063	alcohol dehydrogenase
IPM63_12850	COG0156	8-amino-7-oxononanoate synthase activity
IPM63_12855	COG0405	Gamma-glutamyltransferase
IPM63_12880	COG1994	Peptidase M50
IPM63_12910	COG0750	zinc metalloprotease
IPM63_12950	COG0420	3'-5' exonuclease activity
IPM63_12955	COG4717	serine-type aminopeptidase activity
IPM63_12960	COG1397	ADP-ribosylglycohydrolase
IPM63_12965	COG0420	3'-5' exonuclease activity
IPM63_12990	COG0494	nUDIX hydrolase
IPM63_13025	COG2234	aminopeptidase activity
IPM63_13050	COG1525	nuclease
IPM63_13115	COG4447	cellulose binding
IPM63_13120	COG2135	peptidase activity
IPM63_13180	COG3795	YCII-related domain
IPM63_13185	COG4941	Belongs to the sigma-70 factor family
IPM63_13250	COG0823	Involved in the tonB-independent uptake of proteins
IPM63_13250	COG1506	peptidase
IPM63_13250	COG4946	Tricorn protease homolog
IPM63_13260	COG1506	peptidase
IPM63_13260	COG0823	Involved in the tonB-independent uptake of proteins
IPM63_13260	COG4946	Tricorn protease homolog
IPM63_13265	COG0515	serine threonine protein kinase
IPM63_13265	COG2815	serine threonine protein kinase
IPM63_13280	COG1446	asparaginase
IPM63_13305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IPM63_13310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPM63_13320	COG0587	DNA-directed DNA polymerase activity
IPM63_13350	COG0537	adenosine 5'-monophosphoramidase activity
IPM63_13360	COG2204	response regulator
IPM63_13395	COG0492	ferredoxin-NADP+ reductase activity
IPM63_13405	COG1024	Enoyl-CoA hydratase
IPM63_13430	COG1395	domain, Protein
IPM63_13455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_13480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IPM63_13530	COG0154	amidase activity
IPM63_13550	COG0659	secondary active sulfate transmembrane transporter activity
IPM63_13555	COG3177	Filamentation induced by cAMP protein fic
IPM63_13570	COG3604	Transcriptional regulator
IPM63_13600	COG1028	Short-chain dehydrogenase reductase Sdr
IPM63_13600	COG3321	synthase
IPM63_13600	COG0604	alcohol dehydrogenase
IPM63_13620	COG1073	alpha beta
IPM63_13625	COG0501	Belongs to the peptidase M48B family
IPM63_13670	COG1309	transcriptional regulator
IPM63_13675	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IPM63_13710	COG0493	'glutamate synthase
IPM63_13715	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPM63_13715	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPM63_13715	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPM63_13715	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IPM63_13720	COG0167	dihydroorotate dehydrogenase activity
IPM63_13730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_13755	COG2224	Isocitrate lyase
IPM63_13760	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IPM63_13780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_13795	COG2202	Pas domain
IPM63_13795	COG3920	Histidine kinase
IPM63_13815	COG2362	D-Aminopeptidase
IPM63_13825	COG3547	Transposase (IS116 IS110 IS902 family)
IPM63_13835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPM63_13840	COG1228	amidohydrolase
IPM63_13845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_13850	COG2207	Transcriptional regulator
IPM63_13855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_13860	COG0006	proline dipeptidase activity
IPM63_13885	COG3383	formate dehydrogenase (NAD+) activity
IPM63_13890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IPM63_13900	COG1233	COG1233 Phytoene dehydrogenase and related
IPM63_13910	COG2936	dipeptidyl-peptidase activity
IPM63_13920	COG2197	response regulator
IPM63_13930	COG0577	efflux transmembrane transporter activity
IPM63_13930	COG1136	(ABC) transporter
IPM63_13995	COG0612	Peptidase, M16
IPM63_14010	COG3264	Mechanosensitive ion channel
IPM63_14010	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IPM63_14060	COG2353	YceI-like domain
IPM63_14080	COG1830	Aldolase
IPM63_14095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPM63_14105	COG4191	Histidine kinase
IPM63_14110	COG2204	response regulator
IPM63_14120	COG0745	RESPONSE REGULATOR receiver
IPM63_14130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPM63_14165	COG4974	Belongs to the 'phage' integrase family
IPM63_14180	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IPM63_14185	COG2197	response regulator
IPM63_14190	COG1741	Belongs to the pirin family
IPM63_14195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IPM63_14195	COG4797	methyltransferase
IPM63_14210	COG0517	IMP dehydrogenase activity
IPM63_14210	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IPM63_14220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IPM63_14230	COG2382	esterase
IPM63_14230	COG3507	Belongs to the glycosyl hydrolase 43 family
IPM63_14230	COG3693	PFAM glycoside hydrolase, family 10
IPM63_14235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPM63_14245	COG0490	domain, Protein
IPM63_14245	COG0471	metal ion transport
IPM63_14315	COG1073	alpha beta
IPM63_14335	COG1732	Glycine betaine
IPM63_14350	COG1125	glycine betaine transport
IPM63_14350	COG0517	IMP dehydrogenase activity
IPM63_14355	COG4214	carbohydrate transport
IPM63_14360	COG4213	ABC transporter substrate-binding protein
IPM63_14375	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IPM63_14390	COG0438	transferase activity, transferring glycosyl groups
IPM63_14395	COG2326	polyphosphate kinase activity
IPM63_14410	COG2204	response regulator
IPM63_14435	COG0736	holo-[acyl-carrier-protein] synthase activity
IPM63_14460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IPM63_14485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPM63_14495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM63_14495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM63_14500	COG4591	ABC-type transport system involved in lipoprotein release permease component
IPM63_14505	COG0542	response to heat
IPM63_14510	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPM63_14525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IPM63_14545	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IPM63_14570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPM63_14575	COG1494	fructose-1,6-bisphosphatase
IPM63_14600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IPM63_14615	COG2176	DNA-directed DNA polymerase activity
IPM63_14620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IPM63_14640	COG4589	Belongs to the CDS family
IPM63_14670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM63_14675	COG0454	-acetyltransferase
IPM63_14725	COG3541	Predicted nucleotidyltransferase
IPM63_14755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPM63_14785	COG1388	LysM domain
IPM63_14785	COG3584	3D domain protein
IPM63_14795	COG1595	DNA-templated transcription, initiation
IPM63_14810	COG0681	Belongs to the peptidase S26 family
IPM63_14815	COG0505	Belongs to the CarA family
IPM63_14860	COG1607	acyl-coa hydrolase
IPM63_14870	COG0681	Belongs to the peptidase S26 family
IPM63_14875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IPM63_14920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IPM63_14925	COG0228	four-way junction DNA binding
IPM63_14930	COG1837	Belongs to the UPF0109 family
IPM63_14935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IPM63_14940	COG0336	Belongs to the RNA methyltransferase TrmD family
IPM63_14945	COG0335	large ribosomal subunit rRNA binding
IPM63_14950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IPM63_14965	COG2382	esterase
IPM63_14980	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IPM63_14990	COG0823	Involved in the tonB-independent uptake of proteins
IPM63_15010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPM63_15025	COG1459	type II secretion system
IPM63_15030	COG0140	phosphoribosyl-ATP diphosphatase activity
IPM63_15030	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IPM63_15035	COG0107	imidazoleglycerol-phosphate synthase activity
IPM63_15040	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IPM63_15045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IPM63_15050	COG0131	Imidazoleglycerol-phosphate dehydratase
IPM63_15055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPM63_15060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IPM63_15065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IPM63_15105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IPM63_15115	COG1301	dicarboxylic acid transport
IPM63_15125	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IPM63_15125	COG5479	isomerase activity
IPM63_15135	COG2226	methyltransferase
IPM63_15180	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IPM63_15180	COG0321	lipoyl(octanoyl) transferase activity
IPM63_15185	COG0187	DNA topoisomerase II activity
IPM63_15200	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IPM63_15225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPM63_15240	COG1077	Cell shape determining protein MreB Mrl
IPM63_15255	COG0768	penicillin binding
IPM63_15260	COG0772	Belongs to the SEDS family
IPM63_15295	COG0321	lipoyl(octanoyl) transferase activity
IPM63_15340	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IPM63_15355	COG1966	Carbon starvation protein
IPM63_15370	COG3132	Protein of unknown function, DUF480
IPM63_15380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPM63_15395	COG3852	Histidine kinase
IPM63_15405	COG0438	transferase activity, transferring glycosyl groups
IPM63_15435	COG0612	Peptidase, M16
IPM63_15460	COG0432	Pfam Uncharacterised protein family UPF0047
IPM63_15485	COG0037	tRNA processing
IPM63_15495	COG1104	cysteine desulfurase activity
IPM63_15505	COG1077	Cell shape determining protein MreB Mrl
IPM63_15510	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IPM63_15520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPM63_15535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM63_15550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM63_15560	COG1595	DNA-templated transcription, initiation
IPM63_15565	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IPM63_15575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IPM63_15575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPM63_15580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IPM63_15595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IPM63_15600	COG0798	PFAM Bile acid sodium symporter
IPM63_15610	COG0346	lactoylglutathione lyase activity
IPM63_15620	COG3547	Transposase (IS116 IS110 IS902 family)
IPM63_15630	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IPM63_15645	COG0109	protoheme IX farnesyltransferase activity
IPM63_15645	COG1612	heme a metabolic process
IPM63_15665	COG0531	amino acid
IPM63_15670	COG1115	amino acid carrier protein
IPM63_15720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IPM63_15745	COG3706	GGDEF domain
IPM63_15750	COG0859	PFAM glycosyl transferase family 9
IPM63_15775	COG1543	Belongs to the glycosyl hydrolase 57 family
IPM63_15805	COG0542	response to heat
IPM63_15815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IPM63_15830	COG2890	protein-(glutamine-N5) methyltransferase activity
IPM63_15835	COG2226	methyltransferase
IPM63_15865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IPM63_15880	COG0616	signal peptide processing
IPM63_15890	COG2204	response regulator
IPM63_15930	COG0714	Associated with various cellular activities
IPM63_15950	COG0482	sulfurtransferase activity
IPM63_15955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IPM63_15970	COG1970	mechanosensitive ion channel activity
IPM63_15980	COG2234	aminopeptidase activity
IPM63_16015	COG1132	(ABC) transporter
IPM63_16040	COG0745	RESPONSE REGULATOR receiver
IPM63_16075	COG2205	protein histidine kinase activity
IPM63_16090	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IPM63_16110	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IPM63_16115	COG2388	GCN5-related N-acetyl-transferase
IPM63_16130	COG0277	FAD linked oxidase domain protein
IPM63_16200	COG0012	GTP binding
IPM63_16220	COG0433	COG0433 Predicted ATPase
IPM63_16250	COG2207	Transcriptional regulator
IPM63_16255	COG2897	thiosulfate sulfurtransferase activity
IPM63_16270	COG0308	aminopeptidase N
IPM63_16300	COG0724	RNA recognition motif
IPM63_16315	COG1752	Esterase of the alpha-beta hydrolase superfamily
IPM63_16320	COG1404	Belongs to the peptidase S8 family
IPM63_16335	COG0436	Aminotransferase
IPM63_16355	COG2080	2 iron, 2 sulfur cluster binding
IPM63_16365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IPM63_16380	COG0793	Belongs to the peptidase S41A family
IPM63_16380	COG4946	Tricorn protease homolog
IPM63_16385	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IPM63_16390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPM63_16400	COG0494	nUDIX hydrolase
IPM63_16420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IPM63_16425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPM63_16435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM63_16440	COG1560	Kdo2-lipid A biosynthetic process
IPM63_16445	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IPM63_16450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IPM63_16480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IPM63_16485	COG0746	molybdenum cofactor guanylyltransferase activity
IPM63_16495	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IPM63_16510	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IPM63_16515	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IPM63_16520	COG3186	Phenylalanine-4-hydroxylase
IPM63_16525	COG1522	sequence-specific DNA binding
IPM63_16555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPM63_16560	COG1028	Short-chain dehydrogenase reductase Sdr
IPM63_16565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IPM63_16570	COG0527	aspartate kinase activity
IPM63_16575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPM63_16585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IPM63_16600	COG0515	serine threonine protein kinase
IPM63_16600	COG2815	serine threonine protein kinase
IPM63_16615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPM63_16625	COG0427	acetyl-CoA hydrolase
IPM63_16630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM63_16630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM63_16650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IPM63_16660	COG1324	tolerance protein
IPM63_16665	COG1611	Belongs to the LOG family
IPM63_16685	COG0346	lactoylglutathione lyase activity
IPM63_16695	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IPM63_16700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPM63_16705	COG0346	lactoylglutathione lyase activity
IPM63_16720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPM63_16720	COG2205	protein histidine kinase activity
IPM63_16735	COG2204	response regulator
IPM63_16780	COG1960	acyl-CoA dehydrogenase activity
IPM63_16785	COG1187	pseudouridine synthase activity
IPM63_16795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IPM63_16825	COG0180	Tryptophanyl-tRNA synthetase
IPM63_16830	COG1994	Peptidase M50
IPM63_16895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM63_16895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM63_16920	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IPM63_16930	COG4980	gas vesicle protein
IPM63_16930	COG1674	ftsk spoiiie
IPM63_16940	COG0658	competence protein
IPM63_16940	COG2333	competence protein COMEC
IPM63_16945	COG0138	bifunctional purine biosynthesis protein purh
IPM63_16960	COG1193	negative regulation of DNA recombination
IPM63_16980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM63_16980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPM63_17015	COG1217	gtp-binding protein TYPA
IPM63_17030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IPM63_17045	COG1595	DNA-templated transcription, initiation
IPM63_17050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM63_17055	COG1611	Belongs to the LOG family
IPM63_17090	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IPM63_17115	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IPM63_17120	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IPM63_17130	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IPM63_17135	COG0375	protein maturation
IPM63_17145	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IPM63_17150	COG0298	carbon dioxide binding
IPM63_17155	COG0409	Hydrogenase expression formation protein
IPM63_17165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IPM63_17170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPM63_17185	COG2030	dehydratase
IPM63_17190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IPM63_17205	COG0577	efflux transmembrane transporter activity
IPM63_17220	COG0297	glycogen (starch) synthase activity
IPM63_17265	COG0372	Belongs to the citrate synthase family
IPM63_17300	COG0154	amidase activity
IPM63_17305	COG1272	protein, Hemolysin III
IPM63_17315	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPM63_17325	COG0424	maF-like protein
IPM63_17335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IPM63_17340	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IPM63_17345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IPM63_17385	COG1420	regulation of RNA biosynthetic process
IPM63_17395	COG0443	Heat shock 70 kDa protein
IPM63_17415	COG1610	YqeY-like protein
IPM63_17440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IPM63_17450	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IPM63_17465	COG1028	Short-chain dehydrogenase reductase Sdr
IPM63_17470	COG4969	Belongs to the N-Me-Phe pilin family
IPM63_17475	COG0714	Associated with various cellular activities
IPM63_17510	COG1570	exodeoxyribonuclease VII activity
IPM63_17520	COG1722	exodeoxyribonuclease VII activity
IPM63_17540	COG0670	Belongs to the BI1 family
IPM63_17555	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IPM63_17560	COG0697	spore germination
IPM63_17570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IPM63_17575	COG0049	tRNA binding
IPM63_17580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPM63_17585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPM63_17590	COG0051	transcription antitermination factor activity, RNA binding
IPM63_17595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPM63_17600	COG0088	Forms part of the polypeptide exit tunnel
IPM63_17605	COG0089	rRNA binding
IPM63_17610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPM63_17615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPM63_17620	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPM63_17625	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IPM63_17630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPM63_17635	COG0255	Belongs to the universal ribosomal protein uL29 family
IPM63_17640	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IPM63_17645	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPM63_17650	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IPM63_17655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPM63_17660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IPM63_17665	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPM63_17670	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IPM63_17675	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IPM63_17680	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPM63_17685	COG1841	ribosomal large subunit assembly
IPM63_17690	COG0200	Binds to the 23S rRNA
IPM63_17705	COG0024	Methionine aminopeptidase
IPM63_17710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IPM63_17715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPM63_17725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPM63_17730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPM63_17735	COG0202	RNA polymerase activity
IPM63_17740	COG0203	ribosomal protein L17
IPM63_17745	COG0511	ligase activity, forming carbon-carbon bonds
IPM63_17750	COG0439	Biotin carboxylase
IPM63_17760	COG1185	polyribonucleotide nucleotidyltransferase activity
IPM63_17765	COG0423	glycine-tRNA ligase activity
IPM63_17775	COG0617	tRNA 3'-terminal CCA addition
IPM63_17780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IPM63_17810	COG0156	8-amino-7-oxononanoate synthase activity
IPM63_17815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IPM63_17815	COG4106	trans-aconitate 2-methyltransferase activity
IPM63_17830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IPM63_17835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPM63_17850	COG2264	protein methyltransferase activity
IPM63_17875	COG0303	'Molybdopterin
IPM63_17880	COG1960	acyl-CoA dehydrogenase activity
IPM63_17900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPM63_17910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IPM63_17920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPM63_17935	COG0358	DNA primase activity
IPM63_17955	COG3011	Protein conserved in bacteria
IPM63_17960	COG1228	amidohydrolase
IPM63_17965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM63_17970	COG1228	amidohydrolase
IPM63_17990	COG1309	transcriptional regulator
IPM63_18050	COG1012	belongs to the aldehyde dehydrogenase family
IPM63_18060	COG1953	Uracil, thiamine, allantoin
IPM63_18080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM63_18085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_18090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IPM63_18095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IPM63_18100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPM63_18115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPM63_18120	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM63_18125	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM63_18125	COG0022	dehydrogenase e1 component
IPM63_18260	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPM63_18285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IPM63_18295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM63_18315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IPM63_18330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IPM63_18335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IPM63_18340	COG1120	ATPase activity
IPM63_18360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPM63_18375	COG0300	oxidoreductase activity
IPM63_18380	COG0643	Histidine kinase
IPM63_18380	COG0784	Response regulator, receiver
IPM63_18380	COG2198	Histidine kinase
IPM63_18385	COG0840	transmembrane signaling receptor activity
IPM63_18395	COG0835	chemotaxis
IPM63_18435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPM63_18450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPM63_18455	COG3938	Belongs to the proline racemase family
IPM63_18460	COG0123	including yeast histone deacetylase and acetoin utilization protein
IPM63_18470	COG1024	Enoyl-CoA hydratase
IPM63_18490	COG0484	heat shock protein binding
IPM63_18505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPM63_18520	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
IPM63_18545	COG0402	S-adenosylhomocysteine deaminase activity
IPM63_18550	COG0628	permease
IPM63_18565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IPM63_18575	COG0237	dephospho-CoA kinase activity
IPM63_18580	COG4166	transmembrane transport
IPM63_18585	COG4166	transmembrane transport
IPM63_18590	COG4166	transmembrane transport
IPM63_18590	COG4166	transmembrane transport
IPM63_18595	COG0601	transmembrane transport
IPM63_18600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPM63_18605	COG0444	Belongs to the ABC transporter superfamily
IPM63_18610	COG4608	Belongs to the ABC transporter superfamily
IPM63_18690	COG1136	(ABC) transporter