locus-tag	class	description
IPM66_00020	COG1215	transferase activity, transferring glycosyl groups
IPM66_00045	COG0438	transferase activity, transferring glycosyl groups
IPM66_00050	COG0438	transferase activity, transferring glycosyl groups
IPM66_00055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPM66_00060	COG1216	Glycosyl transferase, family 2
IPM66_00075	COG0438	transferase activity, transferring glycosyl groups
IPM66_00090	COG0367	asparagine synthase
IPM66_00095	COG1083	cytidylyl-transferase
IPM66_00100	COG2226	methyltransferase
IPM66_00115	COG2089	acid synthase
IPM66_00145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPM66_00150	COG0709	Synthesizes selenophosphate from selenide and ATP
IPM66_00155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM66_00160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IPM66_00190	COG0793	Belongs to the peptidase S41A family
IPM66_00190	COG4946	Tricorn protease homolog
IPM66_00195	COG0793	Belongs to the peptidase S41A family
IPM66_00195	COG4946	Tricorn protease homolog
IPM66_00220	COG3132	Protein of unknown function, DUF480
IPM66_00255	COG3179	chitinase
IPM66_00280	COG0297	glycogen (starch) synthase activity
IPM66_00285	COG3118	belongs to the thioredoxin family
IPM66_00290	COG0492	ferredoxin-NADP+ reductase activity
IPM66_00295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IPM66_00305	COG0384	phenazine biosynthesis protein PhzF
IPM66_00310	COG2205	protein histidine kinase activity
IPM66_00335	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IPM66_00345	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IPM66_00350	COG2205	protein histidine kinase activity
IPM66_00375	COG1012	belongs to the aldehyde dehydrogenase family
IPM66_00375	COG2030	dehydratase
IPM66_00380	COG5002	protein histidine kinase activity
IPM66_00395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM66_00400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM66_00410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IPM66_00450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPM66_00475	COG2197	response regulator
IPM66_00495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPM66_00510	COG1215	transferase activity, transferring glycosyl groups
IPM66_00515	COG0726	polysaccharide deacetylase
IPM66_00535	COG0438	transferase activity, transferring glycosyl groups
IPM66_00550	COG0367	asparagine synthase
IPM66_00555	COG0438	transferase activity, transferring glycosyl groups
IPM66_00565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPM66_00570	COG0367	asparagine synthase
IPM66_00610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPM66_00615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPM66_00650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IPM66_00660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IPM66_00685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IPM66_00690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IPM66_00695	COG0506	proline dehydrogenase activity
IPM66_00705	COG2176	DNA-directed DNA polymerase activity
IPM66_00710	COG1999	signal sequence binding
IPM66_00725	COG3394	polysaccharide catabolic process
IPM66_00735	COG0318	PFAM AMP-dependent synthetase and ligase
IPM66_00755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPM66_00765	COG1960	acyl-CoA dehydrogenase activity
IPM66_00770	COG0515	serine threonine protein kinase
IPM66_00770	COG2815	serine threonine protein kinase
IPM66_00780	COG0534	Mate efflux family protein
IPM66_00785	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IPM66_00790	COG4680	protein conserved in bacteria
IPM66_00810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPM66_00810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPM66_00825	COG0535	radical SAM domain protein
IPM66_00830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IPM66_00840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPM66_00850	COG0463	Glycosyl transferase, family 2
IPM66_00865	COG1611	Belongs to the LOG family
IPM66_00885	COG2204	response regulator
IPM66_00900	COG1473	amidohydrolase
IPM66_00910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IPM66_00920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPM66_00935	COG2367	Beta-lactamase
IPM66_00940	COG0515	serine threonine protein kinase
IPM66_00940	COG2815	serine threonine protein kinase
IPM66_00945	COG0515	serine threonine protein kinase
IPM66_00945	COG2815	serine threonine protein kinase
IPM66_00980	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IPM66_00980	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IPM66_00985	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IPM66_00990	COG0732	type I restriction modification DNA specificity domain
IPM66_01005	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IPM66_01015	COG0471	metal ion transport
IPM66_01015	COG3273	potassium ion transport
IPM66_01020	COG0745	RESPONSE REGULATOR receiver
IPM66_01040	COG0517	IMP dehydrogenase activity
IPM66_01050	COG1006	Multisubunit Na H antiporter MnhC subunit
IPM66_01055	COG0651	ATP synthesis coupled electron transport
IPM66_01060	COG1863	multisubunit Na H antiporter MnhE subunit
IPM66_01065	COG2212	antiporter activity
IPM66_01085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IPM66_01090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPM66_01095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IPM66_01100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IPM66_01105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IPM66_01115	COG0072	phenylalanine-tRNA ligase activity
IPM66_01115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM66_01115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM66_01115	COG0072	phenylalanine-tRNA ligase activity
IPM66_01120	COG0072	phenylalanine-tRNA ligase activity
IPM66_01155	COG0318	PFAM AMP-dependent synthetase and ligase
IPM66_01180	COG1293	RNA-binding protein homologous to eukaryotic snRNP
IPM66_01195	COG0800	Aldolase
IPM66_01200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPM66_01210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IPM66_01235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPM66_01240	COG0085	RNA polymerase activity
IPM66_01245	COG0222	ribosome binding
IPM66_01250	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IPM66_01255	COG0081	regulation of translation
IPM66_01260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IPM66_01280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IPM66_01285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPM66_01310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPM66_01320	COG0484	heat shock protein binding
IPM66_01335	COG1420	regulation of RNA biosynthetic process
IPM66_01340	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM66_01345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM66_01350	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM66_01375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IPM66_01390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IPM66_01400	COG1007	ATP synthesis coupled electron transport
IPM66_01415	COG3119	arylsulfatase activity
IPM66_01420	COG3119	arylsulfatase activity
IPM66_01425	COG0596	Alpha beta hydrolase
IPM66_01435	COG0318	PFAM AMP-dependent synthetase and ligase
IPM66_01455	COG2721	sulfolactate sulfo-lyase activity
IPM66_01470	COG2326	polyphosphate kinase activity
IPM66_01475	COG0412	Dienelactone hydrolase
IPM66_01495	COG1595	DNA-templated transcription, initiation
IPM66_01510	COG1132	(ABC) transporter
IPM66_01515	COG1132	(ABC) transporter
IPM66_01555	COG0318	PFAM AMP-dependent synthetase and ligase
IPM66_01565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IPM66_01575	COG1022	Amp-dependent synthetase and ligase
IPM66_01600	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IPM66_01605	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IPM66_01625	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IPM66_01630	COG0126	phosphoglycerate kinase activity
IPM66_01635	COG0149	triose-phosphate isomerase activity
IPM66_01685	COG1484	DNA-dependent DNA replication
IPM66_01705	COG0515	serine threonine protein kinase
IPM66_01760	COG0277	FAD linked oxidase domain protein
IPM66_01780	COG2815	serine threonine protein kinase
IPM66_01780	COG0515	serine threonine protein kinase
IPM66_01820	COG3940	Belongs to the glycosyl hydrolase 43 family
IPM66_01845	COG1555	photosystem II stabilization
IPM66_01865	COG1858	cytochrome C peroxidase
IPM66_01885	COG1129	ABC transporter
IPM66_01890	COG1172	Belongs to the binding-protein-dependent transport system permease family
IPM66_01915	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_01915	COG3347	Dehydrogenase
IPM66_01920	COG4952	isomerase
IPM66_01925	COG4806	L-rhamnose isomerase
IPM66_01925	COG1070	Carbohydrate kinase
IPM66_01995	COG1136	(ABC) transporter
IPM66_01995	COG0577	efflux transmembrane transporter activity
IPM66_02025	COG1136	(ABC) transporter
IPM66_02025	COG0577	efflux transmembrane transporter activity
IPM66_02030	COG1136	(ABC) transporter
IPM66_02030	COG0577	efflux transmembrane transporter activity
IPM66_02035	COG0577	efflux transmembrane transporter activity
IPM66_02040	COG2207	Transcriptional regulator
IPM66_02045	COG0793	Belongs to the peptidase S41A family
IPM66_02045	COG4946	Tricorn protease homolog
IPM66_02055	COG0577	efflux transmembrane transporter activity
IPM66_02055	COG1136	(ABC) transporter
IPM66_02065	COG3119	arylsulfatase activity
IPM66_02070	COG3119	arylsulfatase activity
IPM66_02075	COG3119	arylsulfatase activity
IPM66_02080	COG4447	cellulose binding
IPM66_02085	COG0154	amidase activity
IPM66_02090	COG2308	Evidence 4 Homologs of previously reported genes of
IPM66_02100	COG1305	Transglutaminase-like
IPM66_02105	COG4946	Tricorn protease homolog
IPM66_02105	COG1506	peptidase
IPM66_02105	COG0823	Involved in the tonB-independent uptake of proteins
IPM66_02110	COG0515	serine threonine protein kinase
IPM66_02110	COG2815	serine threonine protein kinase
IPM66_02115	COG2080	2 iron, 2 sulfur cluster binding
IPM66_02120	COG2010	Cytochrome c
IPM66_02120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IPM66_02150	COG3485	protocatechuate 3,4-dioxygenase
IPM66_02185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM66_02190	COG1472	Belongs to the glycosyl hydrolase 3 family
IPM66_02195	COG1609	Transcriptional regulator
IPM66_02245	COG2271	Major facilitator Superfamily
IPM66_02255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM66_02260	COG1024	Enoyl-CoA hydratase
IPM66_02265	COG1024	Enoyl-CoA hydratase
IPM66_02290	COG4106	trans-aconitate 2-methyltransferase activity
IPM66_02295	COG0166	Belongs to the GPI family
IPM66_02335	COG2197	response regulator
IPM66_02340	COG4585	Histidine kinase
IPM66_02345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM66_02370	COG1473	amidohydrolase
IPM66_02395	COG3119	arylsulfatase activity
IPM66_02400	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IPM66_02415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPM66_02435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IPM66_02440	COG0531	amino acid
IPM66_02475	COG1472	Belongs to the glycosyl hydrolase 3 family
IPM66_02480	COG0745	RESPONSE REGULATOR receiver
IPM66_02500	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IPM66_02560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM66_02560	COG0515	serine threonine protein kinase
IPM66_02585	COG0515	serine threonine protein kinase
IPM66_02585	COG2815	serine threonine protein kinase
IPM66_02590	COG0519	Catalyzes the synthesis of GMP from XMP
IPM66_02595	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_02605	COG3119	arylsulfatase activity
IPM66_02620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPM66_02625	COG4221	oxidoreductase activity
IPM66_02630	COG2135	peptidase activity
IPM66_02635	COG1355	regulation of microtubule-based process
IPM66_02645	COG0138	bifunctional purine biosynthesis protein purh
IPM66_02650	COG2204	response regulator
IPM66_02665	COG0842	Transport permease protein
IPM66_02670	COG1131	(ABC) transporter
IPM66_02675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPM66_02690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IPM66_02695	COG1053	succinate dehydrogenase
IPM66_02705	COG0583	DNA-binding transcription factor activity
IPM66_02710	COG1136	(ABC) transporter
IPM66_02710	COG0577	efflux transmembrane transporter activity
IPM66_02715	COG0577	efflux transmembrane transporter activity
IPM66_02720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPM66_02725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPM66_02730	COG2367	Beta-lactamase
IPM66_02745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IPM66_02755	COG0515	serine threonine protein kinase
IPM66_02780	COG0792	nuclease activity
IPM66_02790	COG1295	ribonuclease BN
IPM66_02805	COG1090	epimerase
IPM66_02835	COG0142	geranyltranstransferase activity
IPM66_02850	COG1233	COG1233 Phytoene dehydrogenase and related
IPM66_02880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IPM66_02960	COG1596	polysaccharide export
IPM66_02965	COG0489	protein tyrosine kinase activity
IPM66_02970	COG0489	protein tyrosine kinase activity
IPM66_03025	COG0489	protein tyrosine kinase activity
IPM66_03055	COG4636	protein conserved in cyanobacteria
IPM66_03085	COG2813	Specifically methylates the guanine in position
IPM66_03150	COG2755	lipolytic protein G-D-S-L family
IPM66_03150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPM66_03155	COG2755	lipolytic protein G-D-S-L family
IPM66_03155	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPM66_03165	COG1216	Glycosyl transferase, family 2
IPM66_03175	COG1216	Glycosyl transferase, family 2
IPM66_03200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPM66_03220	COG0367	asparagine synthase
IPM66_03225	COG0438	transferase activity, transferring glycosyl groups
IPM66_03230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM66_03235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM66_03270	COG2264	protein methyltransferase activity
IPM66_03285	COG2208	phosphoserine phosphatase activity
IPM66_03285	COG2770	Histidine kinase
IPM66_03350	COG1595	DNA-templated transcription, initiation
IPM66_03365	COG5002	protein histidine kinase activity
IPM66_03395	COG1196	nuclear chromosome segregation
IPM66_03405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPM66_03415	COG1136	(ABC) transporter
IPM66_03415	COG0577	efflux transmembrane transporter activity
IPM66_03420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IPM66_03425	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IPM66_03475	COG2770	Histidine kinase
IPM66_03475	COG2208	phosphoserine phosphatase activity
IPM66_03480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPM66_03485	COG2226	methyltransferase
IPM66_03490	COG1115	amino acid carrier protein
IPM66_03495	COG1312	Catalyzes the dehydration of D-mannonate
IPM66_03500	COG2133	pyrroloquinoline quinone binding
IPM66_03575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPM66_03580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPM66_03585	COG2345	Transcriptional regulator
IPM66_03595	COG4974	Belongs to the 'phage' integrase family
IPM66_03600	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPM66_03615	COG1475	DNA binding
IPM66_03620	COG1192	Involved in chromosome partitioning
IPM66_03630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPM66_03635	COG0497	DNA recombination
IPM66_03645	COG0629	single-stranded DNA binding
IPM66_03650	COG0825	malonyl-CoA metabolic process
IPM66_03660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IPM66_03660	COG0519	Catalyzes the synthesis of GMP from XMP
IPM66_03665	COG1183	phosphatidylcholine synthase activity
IPM66_03670	COG0688	phosphatidylethanolamine metabolic process
IPM66_03685	COG1214	PFAM Peptidase M22, glycoprotease
IPM66_03690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IPM66_03695	COG2208	phosphoserine phosphatase activity
IPM66_03710	COG2208	phosphoserine phosphatase activity
IPM66_03715	COG1063	alcohol dehydrogenase
IPM66_03720	COG0156	8-amino-7-oxononanoate synthase activity
IPM66_03735	COG0673	inositol 2-dehydrogenase activity
IPM66_03745	COG1012	belongs to the aldehyde dehydrogenase family
IPM66_03745	COG1454	alcohol dehydrogenase
IPM66_03795	COG3005	denitrification pathway
IPM66_03800	COG0723	plastoquinol--plastocyanin reductase activity
IPM66_03805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IPM66_03820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPM66_03825	COG0745	RESPONSE REGULATOR receiver
IPM66_03830	COG2319	Wd-40 repeat
IPM66_03830	COG1672	PFAM Archaeal ATPase
IPM66_03835	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM66_03835	COG0596	Alpha beta hydrolase
IPM66_03860	COG2010	Cytochrome c
IPM66_03860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IPM66_03865	COG3278	Belongs to the heme-copper respiratory oxidase family
IPM66_03885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IPM66_03885	COG0493	'glutamate synthase
IPM66_03940	COG2319	Wd-40 repeat
IPM66_03940	COG4249	Peptidase C14 caspase catalytic subunit p20
IPM66_03955	COG0698	ribose 5-phosphate isomerase
IPM66_03960	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IPM66_03965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IPM66_03980	COG1620	l-lactate permease
IPM66_03995	COG0402	S-adenosylhomocysteine deaminase activity
IPM66_04010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IPM66_04015	COG0488	(ABC) transporter
IPM66_04025	COG0251	oxidation-reduction process
IPM66_04030	COG4447	cellulose binding
IPM66_04040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPM66_04050	COG0745	RESPONSE REGULATOR receiver
IPM66_04055	COG5002	protein histidine kinase activity
IPM66_04105	COG0698	ribose 5-phosphate isomerase
IPM66_04110	COG0436	Aminotransferase
IPM66_04115	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IPM66_04125	COG0402	S-adenosylhomocysteine deaminase activity
IPM66_04140	COG0295	cytidine deaminase activity
IPM66_04145	COG0572	uridine kinase
IPM66_04155	COG1079	Belongs to the binding-protein-dependent transport system permease family
IPM66_04165	COG4603	Belongs to the binding-protein-dependent transport system permease family
IPM66_04220	COG2885	chlorophyll binding
IPM66_04225	COG0823	Involved in the tonB-independent uptake of proteins
IPM66_04240	COG0811	peptide transport
IPM66_04255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IPM66_04260	COG0604	alcohol dehydrogenase
IPM66_04270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPM66_04275	COG1199	ATP-dependent helicase activity
IPM66_04285	COG0602	queuosine metabolic process
IPM66_04290	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IPM66_04300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM66_04385	COG0737	Belongs to the 5'-nucleotidase family
IPM66_04385	COG1525	nuclease
IPM66_04385	COG4085	toxin activity
IPM66_04395	COG5002	protein histidine kinase activity
IPM66_04400	COG1022	Amp-dependent synthetase and ligase
IPM66_04405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPM66_04410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IPM66_04415	COG0052	Belongs to the universal ribosomal protein uS2 family
IPM66_04420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IPM66_04425	COG0528	UMP kinase activity
IPM66_04430	COG0233	cytoplasmic translational termination
IPM66_04435	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_04445	COG0596	Alpha beta hydrolase
IPM66_04460	COG3250	beta-galactosidase activity
IPM66_04475	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IPM66_04480	COG2815	serine threonine protein kinase
IPM66_04480	COG0515	serine threonine protein kinase
IPM66_04495	COG0243	molybdopterin cofactor binding
IPM66_04505	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_04515	COG0251	oxidation-reduction process
IPM66_04520	COG0475	glutathione-regulated potassium exporter activity
IPM66_04555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPM66_04560	COG2204	response regulator
IPM66_04580	COG0537	adenosine 5'-monophosphoramidase activity
IPM66_04620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IPM66_04625	COG1228	amidohydrolase
IPM66_04630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IPM66_04635	COG1960	acyl-CoA dehydrogenase activity
IPM66_04640	COG0438	transferase activity, transferring glycosyl groups
IPM66_04645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPM66_04655	COG0708	Exodeoxyribonuclease III
IPM66_04670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPM66_04695	COG0577	efflux transmembrane transporter activity
IPM66_04700	COG1136	(ABC) transporter
IPM66_04715	COG2814	Major facilitator Superfamily
IPM66_04790	COG0531	amino acid
IPM66_04795	COG2226	methyltransferase
IPM66_04805	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
IPM66_04815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IPM66_04825	COG1132	(ABC) transporter
IPM66_04845	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
IPM66_04860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IPM66_04870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IPM66_04875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IPM66_04880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IPM66_04890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IPM66_04895	COG0416	fatty acid biosynthetic process
IPM66_04900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IPM66_04905	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_04910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPM66_04915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPM66_04975	COG2207	Transcriptional regulator
IPM66_04980	COG0667	Aldo Keto reductase
IPM66_05000	COG0667	Aldo Keto reductase
IPM66_05035	COG3708	Transcriptional regulator
IPM66_05035	COG2207	Transcriptional regulator
IPM66_05080	COG2382	esterase
IPM66_05090	COG0515	serine threonine protein kinase
IPM66_05090	COG2815	serine threonine protein kinase
IPM66_05135	COG0714	Associated with various cellular activities
IPM66_05160	COG3344	reverse transcriptase
IPM66_05175	COG1131	(ABC) transporter
IPM66_05210	COG1657	PFAM Prenyltransferase squalene oxidase
IPM66_05225	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IPM66_05235	COG1562	ergosterol biosynthetic process
IPM66_05240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPM66_05260	COG1408	metallophosphoesterase
IPM66_05265	COG1077	Cell shape determining protein MreB Mrl
IPM66_05335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM66_05350	COG1297	OPT oligopeptide transporter protein
IPM66_05355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPM66_05405	COG1960	acyl-CoA dehydrogenase activity
IPM66_05410	COG0028	Belongs to the TPP enzyme family
IPM66_05425	COG0183	Belongs to the thiolase family
IPM66_05430	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IPM66_05430	COG0662	Cupin 2, conserved barrel domain protein
IPM66_05460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPM66_05465	COG0577	efflux transmembrane transporter activity
IPM66_05465	COG1136	(ABC) transporter
IPM66_05510	COG3591	Belongs to the peptidase S1B family
IPM66_05510	COG4990	cell redox homeostasis
IPM66_05515	COG1523	belongs to the glycosyl hydrolase 13 family
IPM66_05520	COG0235	Class ii aldolase
IPM66_05525	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IPM66_05530	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IPM66_05585	COG1468	defense response to virus
IPM66_05585	COG1518	maintenance of DNA repeat elements
IPM66_05595	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IPM66_05630	COG0702	epimerase
IPM66_05655	COG0651	ATP synthesis coupled electron transport
IPM66_05660	COG0650	Formate hydrogenlyase subunit 4
IPM66_05670	COG0651	ATP synthesis coupled electron transport
IPM66_05675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM66_05675	COG0649	NAD binding
IPM66_05690	COG2815	serine threonine protein kinase
IPM66_05690	COG0515	serine threonine protein kinase
IPM66_05695	COG0659	secondary active sulfate transmembrane transporter activity
IPM66_05705	COG2271	Major facilitator Superfamily
IPM66_05745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IPM66_05770	COG1595	DNA-templated transcription, initiation
IPM66_05820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM66_05825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM66_05830	COG1862	Preprotein translocase
IPM66_05835	COG0343	queuine tRNA-ribosyltransferase activity
IPM66_05840	COG1160	GTP binding
IPM66_05890	COG0673	inositol 2-dehydrogenase activity
IPM66_05920	COG0148	phosphopyruvate hydratase activity
IPM66_05935	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IPM66_05945	COG0022	dehydrogenase e1 component
IPM66_05950	COG0531	amino acid
IPM66_05955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPM66_05985	COG1486	melibiose metabolic process
IPM66_06015	COG1834	amidinotransferase
IPM66_06020	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_06025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPM66_06030	COG0196	riboflavin kinase activity
IPM66_06035	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IPM66_06035	COG0321	lipoyl(octanoyl) transferase activity
IPM66_06065	COG1309	transcriptional regulator
IPM66_06075	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IPM66_06095	COG3104	oligopeptide transport
IPM66_06105	COG1012	belongs to the aldehyde dehydrogenase family
IPM66_06110	COG0686	Belongs to the AlaDH PNT family
IPM66_06160	COG3710	Transcriptional regulator
IPM66_06165	COG1960	acyl-CoA dehydrogenase activity
IPM66_06195	COG0515	serine threonine protein kinase
IPM66_06195	COG2815	serine threonine protein kinase
IPM66_06200	COG1067	ATP-dependent peptidase activity
IPM66_06210	COG3179	chitinase
IPM66_06220	COG0504	CTP synthase activity
IPM66_06250	COG2271	Major facilitator Superfamily
IPM66_06255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM66_06265	COG0517	IMP dehydrogenase activity
IPM66_06265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IPM66_06270	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPM66_06275	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPM66_06275	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPM66_06285	COG0489	protein tyrosine kinase activity
IPM66_06290	COG0316	Belongs to the HesB IscA family
IPM66_06295	COG1592	Rubrerythrin
IPM66_06300	COG0247	lactate metabolic process
IPM66_06310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IPM66_06335	COG0564	pseudouridine synthase activity
IPM66_06355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPM66_06360	COG0436	Aminotransferase
IPM66_06365	COG2234	aminopeptidase activity
IPM66_06400	COG1136	(ABC) transporter
IPM66_06405	COG0577	efflux transmembrane transporter activity
IPM66_06410	COG0577	efflux transmembrane transporter activity
IPM66_06420	COG4191	Histidine kinase
IPM66_06445	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IPM66_06455	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IPM66_06465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPM66_06475	COG0151	Belongs to the GarS family
IPM66_06480	COG0577	efflux transmembrane transporter activity
IPM66_06480	COG1136	(ABC) transporter
IPM66_06485	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IPM66_06510	COG1063	alcohol dehydrogenase
IPM66_06520	COG1129	ABC transporter
IPM66_06525	COG1172	Belongs to the binding-protein-dependent transport system permease family
IPM66_06530	COG0179	Fumarylacetoacetate (FAA) hydrolase
IPM66_06535	COG1070	Carbohydrate kinase
IPM66_06545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPM66_06555	COG1506	peptidase
IPM66_06555	COG0823	Involved in the tonB-independent uptake of proteins
IPM66_06555	COG4946	Tricorn protease homolog
IPM66_06565	COG2084	Dehydrogenase
IPM66_06575	COG1234	tRNA 3'-trailer cleavage
IPM66_06610	COG1136	(ABC) transporter
IPM66_06625	COG4771	TonB-dependent receptor
IPM66_06665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IPM66_06670	COG0527	aspartate kinase activity
IPM66_06670	COG0460	homoserine dehydrogenase
IPM66_06690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IPM66_06720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPM66_06740	COG0515	serine threonine protein kinase
IPM66_06740	COG2815	serine threonine protein kinase
IPM66_06775	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IPM66_06780	COG1605	Chorismate mutase
IPM66_06780	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IPM66_06785	COG0159	tryptophan synthase activity
IPM66_06795	COG0133	tryptophan synthase activity
IPM66_06800	COG0135	phosphoribosylanthranilate isomerase activity
IPM66_06810	COG0134	indole-3-glycerol-phosphate synthase activity
IPM66_06815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IPM66_06820	COG0512	Glutamine amidotransferase of anthranilate synthase
IPM66_06830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPM66_06845	COG0140	phosphoribosyl-ATP diphosphatase activity
IPM66_06845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IPM66_06855	COG0107	imidazoleglycerol-phosphate synthase activity
IPM66_06860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPM66_06865	COG0045	succinate-CoA ligase (ADP-forming) activity
IPM66_06875	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IPM66_06880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPM66_06885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IPM66_06885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IPM66_06890	COG0552	protein localization to endoplasmic reticulum
IPM66_06900	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IPM66_06915	COG0577	efflux transmembrane transporter activity
IPM66_06920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPM66_06975	COG2032	superoxide dismutase activity
IPM66_06980	COG0205	6-phosphofructokinase activity
IPM66_06985	COG0205	6-phosphofructokinase activity
IPM66_06990	COG0823	Involved in the tonB-independent uptake of proteins
IPM66_06995	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IPM66_07000	COG0823	Involved in the tonB-independent uptake of proteins
IPM66_07000	COG1506	peptidase
IPM66_07000	COG4946	Tricorn protease homolog
IPM66_07050	COG1088	dTDP-glucose 4,6-dehydratase activity
IPM66_07060	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IPM66_07065	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IPM66_07095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPM66_07100	COG1858	cytochrome C peroxidase
IPM66_07125	COG0314	molybdopterin synthase activity
IPM66_07130	COG0519	Catalyzes the synthesis of GMP from XMP
IPM66_07130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IPM66_07175	COG4993	Dehydrogenase
IPM66_07180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IPM66_07205	COG0673	inositol 2-dehydrogenase activity
IPM66_07210	COG1940	carbohydrate kinase activity
IPM66_07215	COG2211	Major facilitator Superfamily
IPM66_07230	COG2814	Major facilitator Superfamily
IPM66_07235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPM66_07300	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IPM66_07325	COG1136	(ABC) transporter
IPM66_07325	COG0577	efflux transmembrane transporter activity
IPM66_07345	COG0165	Argininosuccinate lyase
IPM66_07360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IPM66_07370	COG3591	Belongs to the peptidase S1B family
IPM66_07375	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_07380	COG2027	D-alanyl-D-alanine carboxypeptidase
IPM66_07390	COG0714	Associated with various cellular activities
IPM66_07395	COG0181	hydroxymethylbilane synthase activity
IPM66_07405	COG2204	response regulator
IPM66_07420	COG5002	protein histidine kinase activity
IPM66_07425	COG0730	response to heat
IPM66_07440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IPM66_07445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IPM66_07475	COG0437	4 iron, 4 sulfur cluster binding
IPM66_07485	COG1643	Atp-dependent helicase
IPM66_07500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IPM66_07505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPM66_07525	COG1253	flavin adenine dinucleotide binding
IPM66_07540	COG0776	regulation of translation
IPM66_07580	COG1674	ftsk spoiiie
IPM66_07585	COG1914	H( )-stimulated, divalent metal cation uptake system
IPM66_07595	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IPM66_07610	COG0577	efflux transmembrane transporter activity
IPM66_07610	COG1136	(ABC) transporter
IPM66_07620	COG2382	esterase
IPM66_07625	COG3507	Belongs to the glycosyl hydrolase 43 family
IPM66_07625	COG2382	esterase
IPM66_07625	COG3693	PFAM glycoside hydrolase, family 10
IPM66_07640	COG0673	inositol 2-dehydrogenase activity
IPM66_07650	COG3279	Response regulator of the LytR AlgR family
IPM66_07670	COG1741	Belongs to the pirin family
IPM66_07700	COG2072	flavoprotein involved in K transport
IPM66_07705	COG3604	Transcriptional regulator
IPM66_07825	COG2909	trisaccharide binding
IPM66_07830	COG0673	inositol 2-dehydrogenase activity
IPM66_07845	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_07865	COG1218	3'(2'),5'-bisphosphate nucleotidase
IPM66_07885	COG0514	ATP-dependent DNA helicase (RecQ)
IPM66_07925	COG2204	response regulator
IPM66_07995	COG2161	toxin-antitoxin pair type II binding
IPM66_08010	COG1074	ATP-dependent DNA helicase activity
IPM66_08015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPM66_08030	COG4206	TonB-dependent receptor
IPM66_08060	COG0513	Belongs to the DEAD box helicase family
IPM66_08065	COG0724	RNA recognition motif
IPM66_08080	COG3383	formate dehydrogenase (NAD+) activity
IPM66_08085	COG2814	Major facilitator Superfamily
IPM66_08095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IPM66_08095	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IPM66_08105	COG1216	Glycosyl transferase, family 2
IPM66_08115	COG1649	PFAM Uncharacterised BCR, COG1649
IPM66_08115	COG0726	polysaccharide deacetylase
IPM66_08145	COG0493	'glutamate synthase
IPM66_08155	COG0438	transferase activity, transferring glycosyl groups
IPM66_08170	COG0546	phosphoglycolate phosphatase activity
IPM66_08170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IPM66_08180	COG0028	Belongs to the TPP enzyme family
IPM66_08210	COG0167	dihydroorotate dehydrogenase activity
IPM66_08215	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPM66_08215	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPM66_08215	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPM66_08215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IPM66_08235	COG0589	response to stress
IPM66_08240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPM66_08245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPM66_08250	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM66_08255	COG0022	dehydrogenase e1 component
IPM66_08255	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM66_08260	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IPM66_08265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPM66_08285	COG1022	Amp-dependent synthetase and ligase
IPM66_08295	COG0071	Belongs to the small heat shock protein (HSP20) family
IPM66_08355	COG0612	Peptidase, M16
IPM66_08360	COG0542	response to heat
IPM66_08365	COG0459	protein refolding
IPM66_08370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPM66_08375	COG0542	response to heat
IPM66_08380	COG0071	Belongs to the small heat shock protein (HSP20) family
IPM66_08415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPM66_08420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM66_08465	COG4191	Histidine kinase
IPM66_08470	COG2204	response regulator
IPM66_08475	COG1136	(ABC) transporter
IPM66_08480	COG0577	efflux transmembrane transporter activity
IPM66_08480	COG1136	(ABC) transporter
IPM66_08485	COG4591	ABC-type transport system involved in lipoprotein release permease component
IPM66_08485	COG1136	(ABC) transporter
IPM66_08495	COG0745	RESPONSE REGULATOR receiver
IPM66_08505	COG0589	response to stress
IPM66_08515	COG3383	formate dehydrogenase (NAD+) activity
IPM66_08525	COG0205	6-phosphofructokinase activity
IPM66_08530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM66_08535	COG1193	negative regulation of DNA recombination
IPM66_08540	COG1012	belongs to the aldehyde dehydrogenase family
IPM66_08555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPM66_08560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IPM66_08600	COG1136	(ABC) transporter
IPM66_08640	COG2086	electron transfer activity
IPM66_08645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IPM66_08690	COG0242	peptide deformylase activity
IPM66_08695	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IPM66_08700	COG0626	cystathionine gamma-synthase activity
IPM66_08705	COG0631	protein serine/threonine phosphatase activity
IPM66_08715	COG2204	response regulator
IPM66_08750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPM66_08750	COG0574	Belongs to the PEP-utilizing enzyme family
IPM66_08755	COG1381	Involved in DNA repair and RecF pathway recombination
IPM66_08785	COG0584	glycerophosphoryl diester phosphodiesterase
IPM66_08845	COG0509	glycine decarboxylation via glycine cleavage system
IPM66_08850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPM66_08855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPM66_08865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPM66_08870	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IPM66_08880	COG1595	DNA-templated transcription, initiation
IPM66_08885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IPM66_08890	COG0215	cysteine-tRNA ligase activity
IPM66_08895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPM66_08900	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IPM66_08915	COG0459	protein refolding
IPM66_08920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPM66_08925	COG3829	transcription factor binding
IPM66_08930	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IPM66_08935	COG0745	RESPONSE REGULATOR receiver
IPM66_08940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IPM66_08955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPM66_08960	COG4535	Mg2 and Co2 transporter CorC
IPM66_08965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IPM66_08970	COG2264	protein methyltransferase activity
IPM66_08975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IPM66_08990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPM66_09010	COG0450	alkyl hydroperoxide reductase
IPM66_09015	COG0735	belongs to the Fur family
IPM66_09055	COG0113	porphobilinogen synthase activity
IPM66_09105	COG0489	protein tyrosine kinase activity
IPM66_09120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM66_09125	COG1446	asparaginase
IPM66_09140	COG2234	aminopeptidase activity
IPM66_09150	COG1595	DNA-templated transcription, initiation
IPM66_09170	COG0519	Catalyzes the synthesis of GMP from XMP
IPM66_09185	COG0174	glutamine synthetase
IPM66_09190	COG0531	amino acid
IPM66_09205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IPM66_09210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IPM66_09210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPM66_09215	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IPM66_09225	COG0235	Class ii aldolase
IPM66_09235	COG0632	four-way junction helicase activity
IPM66_09240	COG2255	four-way junction helicase activity
IPM66_09245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IPM66_09275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IPM66_09275	COG0596	Alpha beta hydrolase
IPM66_09300	COG0673	inositol 2-dehydrogenase activity
IPM66_09315	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IPM66_09325	COG2226	methyltransferase
IPM66_09330	COG0438	transferase activity, transferring glycosyl groups
IPM66_09340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IPM66_09345	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_09355	COG1615	UPF0182 protein
IPM66_09365	COG0243	molybdopterin cofactor binding
IPM66_09370	COG0437	4 iron, 4 sulfur cluster binding
IPM66_09390	COG2223	nitrite transmembrane transporter activity
IPM66_09400	COG2197	response regulator
IPM66_09415	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IPM66_09420	COG1140	nitrate reductase beta subunit
IPM66_09430	COG2181	nitrate reductase activity
IPM66_09440	COG0437	4 iron, 4 sulfur cluster binding
IPM66_09465	COG2223	nitrite transmembrane transporter activity
IPM66_09505	COG0322	excinuclease ABC activity
IPM66_09515	COG0012	GTP binding
IPM66_09530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IPM66_09535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IPM66_09535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IPM66_09545	COG0495	leucyl-tRNA aminoacylation
IPM66_09575	COG1595	DNA-templated transcription, initiation
IPM66_09605	COG0358	DNA primase activity
IPM66_09610	COG1193	negative regulation of DNA recombination
IPM66_09625	COG2719	SpoVR family
IPM66_09630	COG0187	DNA topoisomerase II activity
IPM66_09635	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPM66_09645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPM66_09660	COG1959	2 iron, 2 sulfur cluster binding
IPM66_09665	COG0719	Fe-S assembly protein
IPM66_09675	COG0396	ATPase activity
IPM66_09680	COG0719	Fe-S assembly protein
IPM66_09685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPM66_09690	COG0822	iron-sulfur transferase activity
IPM66_09730	COG2814	Major facilitator Superfamily
IPM66_09740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPM66_09780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM66_09870	COG0793	Belongs to the peptidase S41A family
IPM66_09870	COG4946	Tricorn protease homolog
IPM66_09885	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IPM66_09890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPM66_09915	COG0546	phosphoglycolate phosphatase activity
IPM66_09920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPM66_09925	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IPM66_09940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IPM66_09945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IPM66_09950	COG0066	3-isopropylmalate dehydratase activity
IPM66_09955	COG0473	3-isopropylmalate dehydrogenase activity
IPM66_09960	COG0028	Belongs to the TPP enzyme family
IPM66_09965	COG0440	acetolactate synthase activity
IPM66_09970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IPM66_09980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IPM66_09990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IPM66_10010	COG0137	argininosuccinate synthase activity
IPM66_10015	COG0492	ferredoxin-NADP+ reductase activity
IPM66_10020	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IPM66_10030	COG0612	Peptidase, M16
IPM66_10035	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IPM66_10050	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IPM66_10060	COG2373	Large extracellular alpha-helical protein
IPM66_10065	COG1058	Belongs to the CinA family
IPM66_10065	COG1546	Belongs to the CinA family
IPM66_10070	COG0124	histidyl-tRNA synthetase
IPM66_10075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IPM66_10090	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_10100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPM66_10105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IPM66_10115	COG0280	phosphate acetyltransferase
IPM66_10120	COG0586	Pfam SNARE associated Golgi protein
IPM66_10145	COG1022	Amp-dependent synthetase and ligase
IPM66_10215	COG1506	peptidase
IPM66_10215	COG4946	Tricorn protease homolog
IPM66_10215	COG0823	Involved in the tonB-independent uptake of proteins
IPM66_10235	COG1735	metal-dependent hydrolase with the TIM-barrel fold
IPM66_10260	COG3661	Belongs to the glycosyl hydrolase 67 family
IPM66_10265	COG4948	Mandelate Racemase Muconate Lactonizing
IPM66_10275	COG0823	Involved in the tonB-independent uptake of proteins
IPM66_10280	COG0577	efflux transmembrane transporter activity
IPM66_10280	COG1136	(ABC) transporter
IPM66_10285	COG1136	(ABC) transporter
IPM66_10285	COG0577	efflux transmembrane transporter activity
IPM66_10345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPM66_10345	COG3153	acetyltransferase
IPM66_10350	COG3153	acetyltransferase
IPM66_10350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPM66_10385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IPM66_10405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPM66_10430	COG2337	Toxic component of a toxin-antitoxin (TA) module
IPM66_10460	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_10475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM66_10560	COG1755	Isoprenylcysteine carboxyl methyltransferase
IPM66_10570	COG0114	fumarate hydratase activity
IPM66_10650	COG1222	aaa ATPase
IPM66_10695	COG2337	Toxic component of a toxin-antitoxin (TA) module
IPM66_10710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IPM66_10720	COG3119	arylsulfatase activity
IPM66_10720	COG3408	Glycogen debranching enzyme
IPM66_10795	COG3119	arylsulfatase activity
IPM66_10810	COG0667	Aldo Keto reductase
IPM66_10815	COG2271	Major facilitator Superfamily
IPM66_10820	COG2944	sequence-specific DNA binding
IPM66_10835	COG2442	InterPro IPR007367
IPM66_10850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IPM66_10850	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IPM66_10880	COG0742	ribosomal rna small subunit methyltransferase
IPM66_10885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IPM66_10895	COG1187	pseudouridine synthase activity
IPM66_10920	COG0557	exoribonuclease II activity
IPM66_10945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPM66_10965	COG0543	2 iron, 2 sulfur cluster binding
IPM66_10985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM66_10995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IPM66_11005	COG0531	amino acid
IPM66_11010	COG0483	inositol monophosphate 1-phosphatase activity
IPM66_11020	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IPM66_11040	COG0542	response to heat
IPM66_11055	COG0463	Glycosyl transferase, family 2
IPM66_11060	COG1408	metallophosphoesterase
IPM66_11095	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM66_11125	COG0793	Belongs to the peptidase S41A family
IPM66_11150	COG0704	Plays a role in the regulation of phosphate uptake
IPM66_11160	COG5002	protein histidine kinase activity
IPM66_11180	COG1506	peptidase
IPM66_11180	COG0823	Involved in the tonB-independent uptake of proteins
IPM66_11185	COG1073	alpha beta
IPM66_11205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPM66_11215	COG0723	plastoquinol--plastocyanin reductase activity
IPM66_11230	COG2010	Cytochrome c
IPM66_11235	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IPM66_11265	COG2770	Histidine kinase
IPM66_11265	COG2208	phosphoserine phosphatase activity
IPM66_11275	COG1366	Belongs to the anti-sigma-factor antagonist family
IPM66_11280	COG1230	cation diffusion facilitator family transporter
IPM66_11315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IPM66_11335	COG0606	chelatase, subunit chli
IPM66_11340	COG0741	lytic transglycosylase activity
IPM66_11340	COG1388	LysM domain
IPM66_11355	COG1704	LemA family
IPM66_11370	COG0482	sulfurtransferase activity
IPM66_11380	COG0076	glutamate decarboxylase activity
IPM66_11405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IPM66_11420	COG0577	efflux transmembrane transporter activity
IPM66_11420	COG1136	(ABC) transporter
IPM66_11425	COG1136	(ABC) transporter
IPM66_11430	COG0105	UTP biosynthetic process
IPM66_11440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPM66_11445	COG3844	kynureninase activity
IPM66_11450	COG3483	tryptophan 2,3-dioxygenase activity
IPM66_11455	COG4447	cellulose binding
IPM66_11465	COG0489	protein tyrosine kinase activity
IPM66_11470	COG3409	Peptidoglycan-binding domain 1 protein
IPM66_11470	COG3267	Type II secretory pathway component ExeA
IPM66_11480	COG4152	abc transporter atp-binding protein
IPM66_11495	COG1480	7TM receptor with intracellular HD hydrolase
IPM66_11500	COG0123	including yeast histone deacetylase and acetoin utilization protein
IPM66_11515	COG0460	homoserine dehydrogenase
IPM66_11520	COG1252	NADH dehydrogenase
IPM66_11525	COG5002	protein histidine kinase activity
IPM66_11530	COG0745	RESPONSE REGULATOR receiver
IPM66_11535	COG1324	tolerance protein
IPM66_11545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IPM66_11560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IPM66_11565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPM66_11585	COG0438	transferase activity, transferring glycosyl groups
IPM66_11590	COG0367	asparagine synthase
IPM66_11605	COG2096	Adenosyltransferase
IPM66_11610	COG0438	transferase activity, transferring glycosyl groups
IPM66_11615	COG1216	Glycosyl transferase, family 2
IPM66_11615	COG1442	glycosyl transferase family 8
IPM66_11625	COG1215	transferase activity, transferring glycosyl groups
IPM66_11645	COG0438	transferase activity, transferring glycosyl groups
IPM66_11675	COG1494	fructose-1,6-bisphosphatase
IPM66_11700	COG1595	DNA-templated transcription, initiation
IPM66_11710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM66_11720	COG0352	thiamine-phosphate diphosphorylase activity
IPM66_11740	COG5002	protein histidine kinase activity
IPM66_11775	COG0352	thiamine-phosphate diphosphorylase activity
IPM66_11775	COG0351	phosphomethylpyrimidine kinase
IPM66_11785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IPM66_11790	COG1832	CoA-binding protein
IPM66_11805	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IPM66_11815	COG1872	DUF167
IPM66_11820	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPM66_11825	COG0481	GTPase activity
IPM66_11835	COG1668	transmembrane transport
IPM66_11845	COG3956	TIGRFAM MazG family protein
IPM66_11860	COG1477	protein flavinylation
IPM66_11865	COG0673	inositol 2-dehydrogenase activity
IPM66_11870	COG0673	inositol 2-dehydrogenase activity
IPM66_11880	COG1940	carbohydrate kinase activity
IPM66_11885	COG4974	Belongs to the 'phage' integrase family
IPM66_11890	COG1663	tetraacyldisaccharide 4'-kinase activity
IPM66_11895	COG1519	Transferase
IPM66_11900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPM66_11905	COG1692	metallophosphoesterase
IPM66_11910	COG0579	oxidoreductase
IPM66_11925	COG0758	DNA mediated transformation
IPM66_11940	COG1691	(AIR) carboxylase
IPM66_11945	COG0163	prenyltransferase activity
IPM66_11960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IPM66_11970	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IPM66_11975	COG0656	L-ascorbic acid biosynthetic process
IPM66_11980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IPM66_12000	COG0154	amidase activity
IPM66_12035	COG3903	Transcriptional regulator
IPM66_12035	COG3629	intracellular signal transduction
IPM66_12040	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IPM66_12045	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPM66_12055	COG2823	Periplasmic or secreted lipoprotein
IPM66_12060	COG4191	Histidine kinase
IPM66_12065	COG2204	response regulator
IPM66_12070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IPM66_12075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM66_12090	COG1953	Uracil, thiamine, allantoin
IPM66_12100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPM66_12105	COG1012	belongs to the aldehyde dehydrogenase family
IPM66_12110	COG2814	Major facilitator Superfamily
IPM66_12120	COG0237	dephospho-CoA kinase activity
IPM66_12125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IPM66_12145	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IPM66_12180	COG0659	secondary active sulfate transmembrane transporter activity
IPM66_12185	COG0288	reversible hydration of carbon dioxide
IPM66_12190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM66_12195	COG1404	Belongs to the peptidase S8 family
IPM66_12205	COG0463	Glycosyl transferase, family 2
IPM66_12265	COG1595	DNA-templated transcription, initiation
IPM66_12290	COG3118	belongs to the thioredoxin family
IPM66_12295	COG1136	(ABC) transporter
IPM66_12315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IPM66_12330	COG0673	inositol 2-dehydrogenase activity
IPM66_12340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPM66_12345	COG3428	Bacterial PH domain
IPM66_12375	COG1131	(ABC) transporter
IPM66_12405	COG1560	Kdo2-lipid A biosynthetic process
IPM66_12410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPM66_12420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IPM66_12430	COG1366	Belongs to the anti-sigma-factor antagonist family
IPM66_12440	COG1490	D-aminoacyl-tRNA deacylase activity
IPM66_12480	COG2815	serine threonine protein kinase
IPM66_12480	COG0515	serine threonine protein kinase
IPM66_12485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPM66_12490	COG1253	flavin adenine dinucleotide binding
IPM66_12515	COG0347	Belongs to the P(II) protein family
IPM66_12520	COG0004	ammonium transporteR
IPM66_12525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IPM66_12540	COG0070	glutamate synthase
IPM66_12540	COG0067	glutamate synthase
IPM66_12540	COG0069	glutamate synthase activity
IPM66_12545	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IPM66_12550	COG0006	proline dipeptidase activity
IPM66_12585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPM66_12590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IPM66_12595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPM66_12640	COG0776	regulation of translation
IPM66_12645	COG0616	signal peptide processing
IPM66_12650	COG2183	response to ionizing radiation
IPM66_12650	COG0539	negative regulation of cytoplasmic translation
IPM66_12655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IPM66_12660	COG1187	pseudouridine synthase activity
IPM66_12670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IPM66_12705	COG3383	formate dehydrogenase (NAD+) activity
IPM66_12715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM66_12730	COG0673	inositol 2-dehydrogenase activity
IPM66_12735	COG0367	asparagine synthase
IPM66_12745	COG0438	transferase activity, transferring glycosyl groups
IPM66_12755	COG0438	transferase activity, transferring glycosyl groups
IPM66_12785	COG1215	transferase activity, transferring glycosyl groups
IPM66_12790	COG1216	Glycosyl transferase, family 2
IPM66_12790	COG0463	Glycosyl transferase, family 2
IPM66_12795	COG1215	transferase activity, transferring glycosyl groups
IPM66_12810	COG0367	asparagine synthase
IPM66_12815	COG0489	protein tyrosine kinase activity
IPM66_12815	COG3206	protein involved in exopolysaccharide biosynthesis
IPM66_12820	COG1596	polysaccharide export
IPM66_12825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPM66_12835	COG1899	peptidyl-lysine modification to peptidyl-hypusine
IPM66_12845	COG1619	proteins homologs of microcin C7 resistance protein MccF
IPM66_12860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IPM66_12865	COG0799	negative regulation of ribosome biogenesis
IPM66_12870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IPM66_12875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IPM66_12880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IPM66_12885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IPM66_12890	COG1595	DNA-templated transcription, initiation
IPM66_12900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPM66_12925	COG3852	Histidine kinase
IPM66_12930	COG2204	response regulator
IPM66_12940	COG2022	thiamine diphosphate biosynthetic process
IPM66_12950	COG0484	heat shock protein binding
IPM66_12965	COG0284	orotidine-5'-phosphate decarboxylase activity
IPM66_12970	COG0739	heme binding
IPM66_12995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPM66_13005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM66_13020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPM66_13025	COG1573	uracil-dna glycosylase
IPM66_13030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IPM66_13035	COG1758	RNA polymerase activity
IPM66_13040	COG0194	GDP metabolic process
IPM66_13045	COG1561	YicC-like family, N-terminal region
IPM66_13050	COG1132	(ABC) transporter
IPM66_13065	COG1329	Transcriptional regulator
IPM66_13070	COG0433	COG0433 Predicted ATPase
IPM66_13085	COG4134	Bacterial extracellular solute-binding protein
IPM66_13090	COG3842	ATPase activity
IPM66_13095	COG1234	tRNA 3'-trailer cleavage
IPM66_13110	COG0745	RESPONSE REGULATOR receiver
IPM66_13115	COG2205	protein histidine kinase activity
IPM66_13135	COG0047	phosphoribosylformylglycinamidine synthase activity
IPM66_13145	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IPM66_13170	COG0673	inositol 2-dehydrogenase activity
IPM66_13190	COG3584	3D domain protein
IPM66_13190	COG1388	LysM domain
IPM66_13200	COG0859	PFAM glycosyl transferase family 9
IPM66_13205	COG2835	tetraacyldisaccharide 4'-kinase activity
IPM66_13220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM66_13220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM66_13225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM66_13225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM66_13230	COG2186	Transcriptional regulator
IPM66_13235	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_13260	COG2379	hydroxypyruvate reductase
IPM66_13265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPM66_13275	COG0405	Gamma-glutamyltransferase
IPM66_13285	COG0477	Major facilitator Superfamily
IPM66_13305	COG3275	phosphorelay sensor kinase activity
IPM66_13325	COG0318	PFAM AMP-dependent synthetase and ligase
IPM66_13335	COG0205	6-phosphofructokinase activity
IPM66_13340	COG1309	transcriptional regulator
IPM66_13345	COG1022	Amp-dependent synthetase and ligase
IPM66_13355	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPM66_13355	COG1024	Enoyl-CoA hydratase
IPM66_13360	COG0183	Belongs to the thiolase family
IPM66_13365	COG1960	acyl-CoA dehydrogenase activity
IPM66_13370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPM66_13390	COG0577	efflux transmembrane transporter activity
IPM66_13405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPM66_13415	COG0129	dihydroxy-acid dehydratase activity
IPM66_13420	COG2318	DinB family
IPM66_13445	COG1136	(ABC) transporter
IPM66_13445	COG0577	efflux transmembrane transporter activity
IPM66_13455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPM66_13465	COG0463	Glycosyl transferase, family 2
IPM66_13495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM66_13500	COG0540	Belongs to the ATCase OTCase family
IPM66_13505	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IPM66_13515	COG0543	2 iron, 2 sulfur cluster binding
IPM66_13535	COG0318	PFAM AMP-dependent synthetase and ligase
IPM66_13540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPM66_13545	COG0037	tRNA processing
IPM66_13550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPM66_13550	COG0574	Belongs to the PEP-utilizing enzyme family
IPM66_13580	COG0308	aminopeptidase N
IPM66_13585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IPM66_13590	COG1294	oxidase, subunit
IPM66_13595	COG1271	oxidase subunit
IPM66_13610	COG0179	Fumarylacetoacetate (FAA) hydrolase
IPM66_13620	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IPM66_13625	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IPM66_13630	COG3186	Phenylalanine-4-hydroxylase
IPM66_13635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPM66_13645	COG1522	sequence-specific DNA binding
IPM66_13650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPM66_13655	COG0561	phosphatase activity
IPM66_13660	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IPM66_13665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM66_13690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IPM66_13695	COG2949	membrane
IPM66_13700	COG1605	Chorismate mutase
IPM66_13700	COG0077	Prephenate dehydratase
IPM66_13705	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IPM66_13715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IPM66_13755	COG0601	transmembrane transport
IPM66_13760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPM66_13770	COG2226	methyltransferase
IPM66_13775	COG0312	modulator of DNA gyrase
IPM66_13780	COG0312	modulator of DNA gyrase
IPM66_13795	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IPM66_13805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPM66_13845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IPM66_13850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM66_13855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM66_13865	COG5183	chlorophyll binding
IPM66_13865	COG2133	pyrroloquinoline quinone binding
IPM66_13870	COG0668	transmembrane transport
IPM66_13905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPM66_13925	COG1201	RNA secondary structure unwinding
IPM66_13935	COG4636	protein conserved in cyanobacteria
IPM66_13955	COG3083	sulfuric ester hydrolase activity
IPM66_13975	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IPM66_13980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IPM66_14000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IPM66_14005	COG4149	molybdate abc transporter
IPM66_14015	COG0183	Belongs to the thiolase family
IPM66_14020	COG1024	Enoyl-CoA hydratase
IPM66_14020	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPM66_14035	COG2059	Chromate
IPM66_14050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPM66_14055	COG2226	methyltransferase
IPM66_14060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IPM66_14065	COG0101	tRNA pseudouridine synthase activity
IPM66_14070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPM66_14075	COG0575	Belongs to the CDS family
IPM66_14080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IPM66_14110	COG3177	Filamentation induced by cAMP protein fic
IPM66_14115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPM66_14120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IPM66_14140	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IPM66_14145	COG0018	arginyl-trna synthetase
IPM66_14165	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM66_14165	COG0567	Dehydrogenase, E1 component
IPM66_14190	COG0318	PFAM AMP-dependent synthetase and ligase
IPM66_14205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IPM66_14215	COG0628	permease
IPM66_14220	COG0443	Heat shock 70 kDa protein
IPM66_14230	COG0484	heat shock protein binding
IPM66_14235	COG0789	Transcriptional regulator
IPM66_14250	COG0791	NLP P60 protein
IPM66_14270	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IPM66_14325	COG4584	PFAM Integrase catalytic
IPM66_14330	COG1484	DNA-dependent DNA replication
IPM66_14380	COG3189	MarR family transcriptional regulator
IPM66_14470	COG1484	DNA-dependent DNA replication
IPM66_14475	COG4584	PFAM Integrase catalytic
IPM66_14490	COG4584	PFAM Integrase catalytic
IPM66_14595	COG3189	MarR family transcriptional regulator
IPM66_14635	COG1484	DNA-dependent DNA replication
IPM66_14660	COG1715	Restriction endonuclease
IPM66_14910	COG0439	Biotin carboxylase
IPM66_14915	COG0511	ligase activity, forming carbon-carbon bonds
IPM66_14920	COG0203	ribosomal protein L17
IPM66_14925	COG0202	RNA polymerase activity
IPM66_14930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPM66_14935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPM66_14940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPM66_14945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPM66_14950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IPM66_14960	COG0563	adenylate kinase activity
IPM66_14965	COG0201	protein transport
IPM66_14970	COG0200	Binds to the 23S rRNA
IPM66_14975	COG1841	ribosomal large subunit assembly
IPM66_14980	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPM66_14985	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IPM66_14990	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IPM66_14995	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPM66_15005	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPM66_15010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IPM66_15015	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPM66_15020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IPM66_15025	COG0255	Belongs to the universal ribosomal protein uL29 family
IPM66_15030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPM66_15035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IPM66_15040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPM66_15045	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPM66_15050	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPM66_15055	COG0089	rRNA binding
IPM66_15065	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPM66_15070	COG0051	transcription antitermination factor activity, RNA binding
IPM66_15080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPM66_15085	COG0049	tRNA binding
IPM66_15090	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IPM66_15105	COG1607	acyl-coa hydrolase
IPM66_15120	COG0006	proline dipeptidase activity
IPM66_15155	COG0577	efflux transmembrane transporter activity
IPM66_15155	COG1136	(ABC) transporter
IPM66_15175	COG0724	RNA recognition motif
IPM66_15185	COG0259	pyridoxamine-phosphate oxidase activity
IPM66_15200	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IPM66_15215	COG1968	undecaprenyl-diphosphatase activity
IPM66_15220	COG0423	glycine-tRNA ligase activity
IPM66_15235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPM66_15275	COG2366	antibiotic biosynthetic process
IPM66_15285	COG0058	SHG alpha-glucan phosphorylase activity
IPM66_15290	COG1127	ABC transporter
IPM66_15295	COG1127	ABC transporter
IPM66_15310	COG0022	dehydrogenase e1 component
IPM66_15315	COG2154	pterin-4-alpha-carbinolamine dehydratase
IPM66_15320	COG0328	RNA-DNA hybrid ribonuclease activity
IPM66_15325	COG0109	protoheme IX farnesyltransferase activity
IPM66_15330	COG0009	L-threonylcarbamoyladenylate synthase
IPM66_15335	COG4412	M6 family metalloprotease domain protein
IPM66_15335	COG1404	Belongs to the peptidase S8 family
IPM66_15345	COG0521	Mo-molybdopterin cofactor biosynthetic process
IPM66_15360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPM66_15365	COG0450	alkyl hydroperoxide reductase
IPM66_15370	COG0531	amino acid
IPM66_15375	COG0531	amino acid
IPM66_15380	COG0750	zinc metalloprotease
IPM66_15425	COG3852	Histidine kinase
IPM66_15440	COG0432	Pfam Uncharacterised protein family UPF0047
IPM66_15450	COG0659	secondary active sulfate transmembrane transporter activity
IPM66_15455	COG0288	reversible hydration of carbon dioxide
IPM66_15465	COG0673	inositol 2-dehydrogenase activity
IPM66_15475	COG0363	glucosamine-6-phosphate deaminase activity
IPM66_15480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IPM66_15495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPM66_15520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IPM66_15525	COG1570	exodeoxyribonuclease VII activity
IPM66_15530	COG1722	exodeoxyribonuclease VII activity
IPM66_15540	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IPM66_15545	COG0594	ribonuclease P activity
IPM66_15550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPM66_15555	COG0706	membrane insertase activity
IPM66_15565	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IPM66_15575	COG5001	Diguanylate cyclase
IPM66_15575	COG1716	ATPase activity
IPM66_15585	COG2819	hydrolase of the alpha beta superfamily
IPM66_15615	COG0445	tRNA wobble uridine modification
IPM66_15620	COG0357	Ribosomal RNA small subunit methyltransferase G
IPM66_15625	COG1192	Involved in chromosome partitioning
IPM66_15640	COG0402	S-adenosylhomocysteine deaminase activity
IPM66_15715	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IPM66_15720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IPM66_15725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IPM66_15735	COG2130	NADP-dependent
IPM66_15750	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_15755	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IPM66_15780	COG1136	(ABC) transporter
IPM66_15780	COG0577	efflux transmembrane transporter activity
IPM66_15810	COG0791	NLP P60 protein
IPM66_15820	COG4191	Histidine kinase
IPM66_15830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM66_15830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM66_15835	COG0084	hydrolase, TatD family'
IPM66_15840	COG1666	GTP binding
IPM66_15845	COG0142	geranyltranstransferase activity
IPM66_15865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM66_15885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM66_15890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPM66_15900	COG0017	Asparaginyl-tRNA synthetase
IPM66_15905	COG2226	methyltransferase
IPM66_15915	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPM66_15920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPM66_15925	COG0356	it plays a direct role in the translocation of protons across the membrane
IPM66_15955	COG0577	efflux transmembrane transporter activity
IPM66_15960	COG1136	(ABC) transporter
IPM66_15965	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IPM66_15975	COG1612	heme a metabolic process
IPM66_15975	COG0109	protoheme IX farnesyltransferase activity
IPM66_16035	COG1082	Xylose isomerase domain protein TIM barrel
IPM66_16060	COG4191	Histidine kinase
IPM66_16065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPM66_16135	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IPM66_16145	COG3481	metal-dependent phosphohydrolase, HD sub domain
IPM66_16150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPM66_16155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPM66_16170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPM66_16170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPM66_16175	COG0268	Binds directly to 16S ribosomal RNA
IPM66_16185	COG3174	membrane
IPM66_16205	COG0589	response to stress
IPM66_16210	COG2204	response regulator
IPM66_16225	COG2815	serine threonine protein kinase
IPM66_16225	COG0515	serine threonine protein kinase
IPM66_16235	COG0668	transmembrane transport
IPM66_16240	COG2169	Transcriptional regulator
IPM66_16240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IPM66_16250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IPM66_16255	COG0673	inositol 2-dehydrogenase activity
IPM66_16260	COG2115	Belongs to the xylose isomerase family
IPM66_16285	COG0577	efflux transmembrane transporter activity
IPM66_16285	COG1136	(ABC) transporter
IPM66_16295	COG4993	Dehydrogenase
IPM66_16315	COG0577	efflux transmembrane transporter activity
IPM66_16315	COG1136	(ABC) transporter
IPM66_16320	COG0577	efflux transmembrane transporter activity
IPM66_16320	COG1136	(ABC) transporter
IPM66_16330	COG3710	Transcriptional regulator
IPM66_16335	COG1136	(ABC) transporter
IPM66_16335	COG0577	efflux transmembrane transporter activity
IPM66_16340	COG2814	Major facilitator Superfamily
IPM66_16350	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
IPM66_16380	COG2851	Citrate transporter
IPM66_16410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IPM66_16415	COG1993	acr, cog1993
IPM66_16420	COG1993	acr, cog1993
IPM66_16445	COG0662	Cupin 2, conserved barrel domain protein
IPM66_16525	COG0745	RESPONSE REGULATOR receiver
IPM66_16530	COG2205	protein histidine kinase activity
IPM66_16535	COG1070	Carbohydrate kinase
IPM66_16540	COG0076	glutamate decarboxylase activity
IPM66_16555	COG3268	Saccharopine dehydrogenase
IPM66_16560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPM66_16575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPM66_16580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IPM66_16585	COG0527	aspartate kinase activity
IPM66_16590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPM66_16600	COG0720	synthase
IPM66_16605	COG0473	3-isopropylmalate dehydrogenase activity
IPM66_16610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IPM66_16615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPM66_16625	COG0583	DNA-binding transcription factor activity
IPM66_16635	COG0717	Belongs to the dCTP deaminase family
IPM66_16640	COG2610	gluconate transmembrane transporter activity
IPM66_16645	COG1072	(Pantothenic acid kinase))
IPM66_16650	COG0463	Glycosyl transferase, family 2
IPM66_16660	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IPM66_16685	COG0544	peptidyl-prolyl cis-trans isomerase activity
IPM66_16690	COG0740	serine-type endopeptidase activity
IPM66_16695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IPM66_16700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IPM66_16705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPM66_16710	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IPM66_16715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IPM66_16740	COG0398	Pfam SNARE associated Golgi protein
IPM66_16770	COG1505	serine-type exopeptidase activity
IPM66_16805	COG2226	methyltransferase
IPM66_16885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IPM66_16890	COG0802	atpase or kinase
IPM66_16895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IPM66_16895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IPM66_16915	COG1496	oxidoreductase activity
IPM66_16920	COG0736	holo-[acyl-carrier-protein] synthase activity
IPM66_16925	COG0823	Involved in the tonB-independent uptake of proteins
IPM66_16925	COG1506	peptidase
IPM66_16925	COG4946	Tricorn protease homolog
IPM66_16965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IPM66_16990	COG0303	'Molybdopterin
IPM66_16995	COG0315	cyclic pyranopterin monophosphate synthase activity
IPM66_17010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPM66_17030	COG2171	N-acyltransferase activity
IPM66_17080	COG0454	-acetyltransferase
IPM66_17080	COG0456	acetyltransferase
IPM66_17085	COG2252	PERMEase
IPM66_17105	COG4585	Histidine kinase
IPM66_17110	COG0823	Involved in the tonB-independent uptake of proteins
IPM66_17110	COG1506	peptidase
IPM66_17115	COG2234	aminopeptidase activity
IPM66_17120	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_17140	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IPM66_17165	COG0784	Response regulator, receiver
IPM66_17170	COG0577	efflux transmembrane transporter activity
IPM66_17170	COG1136	(ABC) transporter
IPM66_17205	COG0444	Belongs to the ABC transporter superfamily
IPM66_17210	COG4608	Belongs to the ABC transporter superfamily
IPM66_17220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IPM66_17220	COG1796	DNA polymerase
IPM66_17250	COG2815	serine threonine protein kinase
IPM66_17250	COG0515	serine threonine protein kinase
IPM66_17270	COG1304	FMN binding
IPM66_17285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM66_17300	COG5000	phosphorelay sensor kinase activity
IPM66_17305	COG2204	response regulator
IPM66_17315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IPM66_17335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IPM66_17340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IPM66_17340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IPM66_17350	COG0210	DNA helicase
IPM66_17365	COG0726	polysaccharide deacetylase
IPM66_17370	COG0726	polysaccharide deacetylase
IPM66_17375	COG0531	amino acid
IPM66_17410	COG0653	protein targeting
IPM66_17420	COG0419	ATPase involved in DNA repair
IPM66_17445	COG1063	alcohol dehydrogenase
IPM66_17460	COG0596	Alpha beta hydrolase
IPM66_17465	COG2086	electron transfer activity
IPM66_17470	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IPM66_17475	COG0247	lactate metabolic process
IPM66_17475	COG2181	nitrate reductase activity
IPM66_17480	COG1960	acyl-CoA dehydrogenase activity
IPM66_17485	COG1960	acyl-CoA dehydrogenase activity
IPM66_17515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IPM66_17530	COG0037	tRNA processing
IPM66_17545	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IPM66_17550	COG3264	Mechanosensitive ion channel
IPM66_17550	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IPM66_17555	COG1272	protein, Hemolysin III
IPM66_17565	COG0363	glucosamine-6-phosphate deaminase activity
IPM66_17590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IPM66_17595	COG0438	transferase activity, transferring glycosyl groups
IPM66_17600	COG0471	metal ion transport
IPM66_17600	COG3273	potassium ion transport
IPM66_17610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPM66_17620	COG5002	protein histidine kinase activity
IPM66_17635	COG0420	3'-5' exonuclease activity
IPM66_17640	COG0612	Peptidase, M16
IPM66_17650	COG1131	(ABC) transporter
IPM66_17675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IPM66_17680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IPM66_17715	COG0515	serine threonine protein kinase
IPM66_17715	COG2815	serine threonine protein kinase
IPM66_17720	COG1672	PFAM Archaeal ATPase
IPM66_17720	COG2319	Wd-40 repeat
IPM66_17735	COG0714	Associated with various cellular activities
IPM66_17760	COG1960	acyl-CoA dehydrogenase activity
IPM66_17780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPM66_17795	COG1920	GTP binding
IPM66_17800	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IPM66_17825	COG0058	SHG alpha-glucan phosphorylase activity
IPM66_17830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IPM66_17850	COG3344	reverse transcriptase
IPM66_17880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IPM66_17885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM66_17905	COG0535	radical SAM domain protein
IPM66_17920	COG0577	efflux transmembrane transporter activity
IPM66_17920	COG1136	(ABC) transporter
IPM66_17925	COG0577	efflux transmembrane transporter activity
IPM66_17945	COG1515	deoxyribonuclease V activity
IPM66_17950	COG1047	Peptidyl-prolyl cis-trans
IPM66_17975	COG2208	phosphoserine phosphatase activity
IPM66_17980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IPM66_17985	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IPM66_18010	COG2718	Belongs to the UPF0229 family
IPM66_18015	COG2766	serine protein kinase
IPM66_18020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IPM66_18040	COG0516	GMP reductase activity
IPM66_18040	COG0517	IMP dehydrogenase activity
IPM66_18045	COG0277	FAD linked oxidase domain protein
IPM66_18050	COG0352	thiamine-phosphate diphosphorylase activity
IPM66_18065	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IPM66_18080	COG0405	Gamma-glutamyltransferase
IPM66_18090	COG0673	inositol 2-dehydrogenase activity
IPM66_18095	COG0667	Aldo Keto reductase
IPM66_18105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IPM66_18110	COG0728	peptidoglycan biosynthetic process
IPM66_18130	COG1858	cytochrome C peroxidase
IPM66_18135	COG2239	Acts as a magnesium transporter
IPM66_18160	COG3119	arylsulfatase activity
IPM66_18170	COG0281	malic enzyme
IPM66_18175	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_18185	COG0673	inositol 2-dehydrogenase activity
IPM66_18215	COG3608	succinylglutamate desuccinylase aspartoacylase
IPM66_18215	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IPM66_18220	COG1923	regulation of RNA biosynthetic process
IPM66_18225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IPM66_18230	COG0470	DNA polymerase III
IPM66_18235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IPM66_18245	COG1837	Belongs to the UPF0109 family
IPM66_18250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IPM66_18255	COG0336	Belongs to the RNA methyltransferase TrmD family
IPM66_18260	COG0335	large ribosomal subunit rRNA binding
IPM66_18280	COG2137	regulation of response to DNA damage stimulus
IPM66_18285	COG0217	transcriptional regulatory protein
IPM66_18310	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
IPM66_18335	COG0402	S-adenosylhomocysteine deaminase activity
IPM66_18340	COG2855	membrane
IPM66_18370	COG4993	Dehydrogenase
IPM66_18390	COG0517	IMP dehydrogenase activity
IPM66_18390	COG1125	glycine betaine transport
IPM66_18420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPM66_18425	COG4948	Mandelate Racemase Muconate Lactonizing
IPM66_18475	COG0473	3-isopropylmalate dehydrogenase activity
IPM66_18495	COG0277	FAD linked oxidase domain protein
IPM66_18500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IPM66_18510	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IPM66_18515	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IPM66_18525	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IPM66_18530	COG0463	Glycosyl transferase, family 2
IPM66_18535	COG0542	response to heat
IPM66_18540	COG4636	protein conserved in cyanobacteria
IPM66_18550	COG4447	cellulose binding
IPM66_18580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IPM66_18590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM66_18590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM66_18600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPM66_18610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IPM66_18650	COG4964	Belongs to the GSP D family
IPM66_18705	COG0741	lytic transglycosylase activity
IPM66_18705	COG1196	nuclear chromosome segregation
IPM66_18705	COG0739	heme binding
IPM66_18740	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IPM66_18760	COG2361	Protein of unknown function DUF86
IPM66_18765	COG1672	PFAM Archaeal ATPase
IPM66_18765	COG2319	Wd-40 repeat
IPM66_18770	COG2815	serine threonine protein kinase
IPM66_18770	COG0515	serine threonine protein kinase
IPM66_18800	COG4771	TonB-dependent receptor
IPM66_18810	COG0653	protein targeting
IPM66_18830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IPM66_18835	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_18845	COG0673	inositol 2-dehydrogenase activity
IPM66_18860	COG1960	acyl-CoA dehydrogenase activity
IPM66_18865	COG0531	amino acid
IPM66_18870	COG0318	PFAM AMP-dependent synthetase and ligase
IPM66_18880	COG0765	amino acid transport
IPM66_18885	COG0673	inositol 2-dehydrogenase activity
IPM66_18900	COG1940	carbohydrate kinase activity
IPM66_18920	COG0471	metal ion transport
IPM66_18925	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IPM66_18930	COG1595	DNA-templated transcription, initiation
IPM66_18955	COG1994	Peptidase M50
IPM66_18960	COG0180	Tryptophanyl-tRNA synthetase
IPM66_18970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IPM66_18995	COG0745	RESPONSE REGULATOR receiver
IPM66_19005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IPM66_19020	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IPM66_19030	COG0393	Putative heavy-metal-binding
IPM66_19045	COG1012	belongs to the aldehyde dehydrogenase family
IPM66_19050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPM66_19065	COG0475	glutathione-regulated potassium exporter activity
IPM66_19075	COG3273	potassium ion transport
IPM66_19075	COG0471	metal ion transport
IPM66_19080	COG1830	Aldolase
IPM66_19085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPM66_19090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPM66_19095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IPM66_19100	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IPM66_19105	COG1058	Belongs to the CinA family
IPM66_19105	COG1546	Belongs to the CinA family
IPM66_19110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IPM66_19115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPM66_19125	COG1960	acyl-CoA dehydrogenase activity
IPM66_19140	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IPM66_19150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IPM66_19155	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IPM66_19160	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_19180	COG2890	protein-(glutamine-N5) methyltransferase activity
IPM66_19185	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPM66_19190	COG3872	metal-dependent enzyme
IPM66_19195	COG0254	rRNA binding
IPM66_19215	COG4584	PFAM Integrase catalytic
IPM66_19220	COG1484	DNA-dependent DNA replication
IPM66_19275	COG0306	phosphate transporter
IPM66_19295	COG1674	ftsk spoiiie
IPM66_19300	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IPM66_19360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM66_19360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM66_19365	COG1966	Carbon starvation protein
IPM66_19380	COG1132	(ABC) transporter
IPM66_19385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IPM66_19405	COG1024	Enoyl-CoA hydratase
IPM66_19420	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IPM66_19445	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IPM66_19450	COG0101	tRNA pseudouridine synthase activity
IPM66_19455	COG0433	COG0433 Predicted ATPase
IPM66_19465	COG0644	oxidoreductase
IPM66_19480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IPM66_19510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IPM66_19530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IPM66_19540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM66_19540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPM66_19545	COG0424	maF-like protein
IPM66_19560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPM66_19565	COG0154	amidase activity
IPM66_19590	COG3540	Alkaline phosphatase
IPM66_19605	COG2205	protein histidine kinase activity
IPM66_19615	COG2770	Histidine kinase
IPM66_19615	COG2208	phosphoserine phosphatase activity
IPM66_19630	COG3534	alpha-L-arabinofuranosidase
IPM66_19655	COG0800	Aldolase
IPM66_19715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPM66_19720	COG4636	protein conserved in cyanobacteria
IPM66_19725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPM66_19730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IPM66_19750	COG0538	isocitrate dehydrogenase activity
IPM66_19760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPM66_19770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IPM66_19780	COG0745	RESPONSE REGULATOR receiver
IPM66_19785	COG0525	valine-tRNA ligase activity
IPM66_19795	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IPM66_19795	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IPM66_19805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IPM66_19810	COG3344	reverse transcriptase
IPM66_19845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPM66_19850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IPM66_19860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPM66_19885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPM66_19890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IPM66_19900	COG2318	DinB family
IPM66_19905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IPM66_19910	COG0131	Imidazoleglycerol-phosphate dehydratase
IPM66_19915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPM66_19925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IPM66_19930	COG0124	histidyl-tRNA synthetase
IPM66_19935	COG0083	homoserine kinase activity
IPM66_19940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IPM66_19965	COG3876	Protein conserved in bacteria
IPM66_19980	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IPM66_19990	COG0571	ribonuclease III activity
IPM66_20000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPM66_20005	COG1078	dGTPase activity
IPM66_20015	COG0793	Belongs to the peptidase S41A family
IPM66_20060	COG1331	Highly conserved protein containing a thioredoxin domain
IPM66_20065	COG1426	Protein conserved in bacteria
IPM66_20070	COG0517	IMP dehydrogenase activity
IPM66_20070	COG0516	GMP reductase activity
IPM66_20075	COG1217	gtp-binding protein TYPA
IPM66_20085	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IPM66_20090	COG0681	Belongs to the peptidase S26 family
IPM66_20100	COG0505	Belongs to the CarA family
IPM66_20110	COG1845	cytochrome c oxidase, subunit III
IPM66_20115	COG2322	membrane
IPM66_20125	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IPM66_20130	COG2313	pseudouridylate synthase activity
IPM66_20145	COG1131	(ABC) transporter
IPM66_20195	COG1297	OPT oligopeptide transporter protein
IPM66_20200	COG1404	Belongs to the peptidase S8 family
IPM66_20225	COG1136	(ABC) transporter
IPM66_20285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPM66_20285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPM66_20295	COG3119	arylsulfatase activity
IPM66_20305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPM66_20310	COG1597	lipid kinase activity
IPM66_20320	COG0805	protein transport
IPM66_20325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPM66_20350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IPM66_20370	COG1166	arginine decarboxylase activity
IPM66_20410	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IPM66_20415	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IPM66_20420	COG1660	Displays ATPase and GTPase activities
IPM66_20435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPM66_20440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IPM66_20445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IPM66_20450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPM66_20455	COG0628	permease
IPM66_20460	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IPM66_20465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IPM66_20470	COG0586	Pfam SNARE associated Golgi protein
IPM66_20475	COG1082	Xylose isomerase domain protein TIM barrel
IPM66_20480	COG3959	Transketolase, thiamine diphosphate binding domain
IPM66_20485	COG3958	Transketolase
IPM66_20495	COG2390	Transcriptional regulator
IPM66_20505	COG1129	ABC transporter
IPM66_20510	COG1172	Belongs to the binding-protein-dependent transport system permease family
IPM66_20565	COG2815	serine threonine protein kinase
IPM66_20565	COG0515	serine threonine protein kinase
IPM66_20570	COG1024	Enoyl-CoA hydratase
IPM66_20580	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM66_20580	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM66_20590	COG2001	Belongs to the MraZ family
IPM66_20595	COG0275	rRNA processing
IPM66_20605	COG0768	penicillin binding
IPM66_20610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IPM66_20615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPM66_20620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM66_20625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPM66_20630	COG0772	Belongs to the SEDS family
IPM66_20635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPM66_20640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPM66_20655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPM66_20665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IPM66_20670	COG0673	inositol 2-dehydrogenase activity
IPM66_20685	COG0372	Belongs to the citrate synthase family
IPM66_20690	COG0678	peroxiredoxin activity
IPM66_20690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IPM66_20695	COG3191	aminopeptidase activity
IPM66_20710	COG0793	Belongs to the peptidase S41A family
IPM66_20715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IPM66_20720	COG1127	ABC transporter
IPM66_20730	COG1054	Belongs to the UPF0176 family
IPM66_20735	COG2815	serine threonine protein kinase
IPM66_20735	COG0515	serine threonine protein kinase
IPM66_20750	COG1032	radical SAM domain protein
IPM66_20765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IPM66_20770	COG1606	tRNA processing
IPM66_20795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IPM66_20825	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM66_20830	COG0321	lipoyl(octanoyl) transferase activity
IPM66_20835	COG1301	dicarboxylic acid transport
IPM66_20840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IPM66_20855	COG0129	dihydroxy-acid dehydratase activity
IPM66_20865	COG1741	Belongs to the pirin family
IPM66_20870	COG0778	Nitroreductase
IPM66_20875	COG0318	PFAM AMP-dependent synthetase and ligase
IPM66_20885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPM66_20900	COG0318	PFAM AMP-dependent synthetase and ligase
IPM66_20935	COG1752	Esterase of the alpha-beta hydrolase superfamily
IPM66_20950	COG1111	helicase
IPM66_20950	COG1205	dead DEAH box helicase
IPM66_20955	COG0210	DNA helicase
IPM66_20960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPM66_20985	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IPM66_21005	COG0318	PFAM AMP-dependent synthetase and ligase
IPM66_21025	COG3119	arylsulfatase activity
IPM66_21030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPM66_21035	COG4948	Mandelate Racemase Muconate Lactonizing
IPM66_21135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPM66_21140	COG1136	(ABC) transporter
IPM66_21150	COG0577	efflux transmembrane transporter activity
IPM66_21170	COG0598	Magnesium transport protein CorA
IPM66_21185	COG0729	surface antigen
IPM66_21205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPM66_21245	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IPM66_21250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPM66_21255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IPM66_21260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IPM66_21275	COG1752	Esterase of the alpha-beta hydrolase superfamily
IPM66_21290	COG2971	BadF BadG BcrA BcrD
IPM66_21295	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IPM66_21315	COG2706	6-phosphogluconolactonase activity
IPM66_21330	COG2832	Protein of unknown function (DUF454)
IPM66_21340	COG1940	carbohydrate kinase activity
IPM66_21345	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IPM66_21370	COG2234	aminopeptidase activity
IPM66_21375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IPM66_21385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPM66_21465	COG0768	penicillin binding
IPM66_21470	COG0772	Belongs to the SEDS family
IPM66_21510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IPM66_21520	COG2207	Transcriptional regulator
IPM66_21520	COG0662	Cupin 2, conserved barrel domain protein
IPM66_21530	COG1543	Belongs to the glycosyl hydrolase 57 family
IPM66_21550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IPM66_21570	COG2937	Belongs to the GPAT DAPAT family
IPM66_21595	COG0582	viral genome integration into host DNA
IPM66_21660	COG1569	PIN domain
IPM66_21665	COG0863	Belongs to the N(4) N(6)-methyltransferase family
IPM66_21700	COG5433	transposase activity
IPM66_21705	COG2366	antibiotic biosynthetic process
IPM66_21725	COG1136	(ABC) transporter
IPM66_21725	COG0577	efflux transmembrane transporter activity
IPM66_21730	COG2801	Transposase and inactivated derivatives
IPM66_21755	COG0724	RNA recognition motif
IPM66_21760	COG0724	RNA recognition motif
IPM66_21780	COG3275	phosphorelay sensor kinase activity
IPM66_21785	COG3279	Response regulator of the LytR AlgR family
IPM66_21795	COG4946	Tricorn protease homolog
IPM66_21795	COG0793	Belongs to the peptidase S41A family
IPM66_21825	COG0673	inositol 2-dehydrogenase activity
IPM66_21835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPM66_21840	COG5000	phosphorelay sensor kinase activity
IPM66_21840	COG5002	protein histidine kinase activity
IPM66_21845	COG0745	RESPONSE REGULATOR receiver
IPM66_21880	COG2815	serine threonine protein kinase
IPM66_21880	COG0515	serine threonine protein kinase
IPM66_21895	COG2197	response regulator
IPM66_21935	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IPM66_21955	COG2197	response regulator
IPM66_21975	COG2272	Belongs to the type-B carboxylesterase lipase family
IPM66_21980	COG0596	Alpha beta hydrolase
IPM66_22015	COG0515	serine threonine protein kinase
IPM66_22015	COG2815	serine threonine protein kinase
IPM66_22035	COG0515	serine threonine protein kinase
IPM66_22035	COG2815	serine threonine protein kinase
IPM66_22055	COG4104	PAAR repeat-containing protein
IPM66_22105	COG3119	arylsulfatase activity
IPM66_22110	COG0628	permease
IPM66_22145	COG1132	(ABC) transporter
IPM66_22175	COG3119	arylsulfatase activity
IPM66_22180	COG2382	esterase
IPM66_22195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPM66_22200	COG4279	zinc finger
IPM66_22205	COG3119	arylsulfatase activity
IPM66_22210	COG2814	Major facilitator Superfamily
IPM66_22235	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IPM66_22240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IPM66_22255	COG0673	inositol 2-dehydrogenase activity
IPM66_22365	COG3344	reverse transcriptase
IPM66_22375	COG1468	defense response to virus
IPM66_22375	COG1518	maintenance of DNA repeat elements
IPM66_22425	COG1484	DNA-dependent DNA replication
IPM66_22440	COG3012	SEC-C Motif Domain Protein
IPM66_22450	COG3119	arylsulfatase activity
IPM66_22485	COG0577	efflux transmembrane transporter activity
IPM66_22485	COG1136	(ABC) transporter
IPM66_22490	COG1136	(ABC) transporter
IPM66_22490	COG0577	efflux transmembrane transporter activity
IPM66_22495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPM66_22520	COG1595	DNA-templated transcription, initiation
IPM66_22525	COG0515	serine threonine protein kinase
IPM66_22525	COG2815	serine threonine protein kinase
IPM66_22535	COG3540	Alkaline phosphatase
IPM66_22590	COG0129	dihydroxy-acid dehydratase activity
IPM66_22610	COG0673	inositol 2-dehydrogenase activity
IPM66_22615	COG0248	Ppx GppA phosphatase
IPM66_22620	COG2423	ornithine cyclodeaminase activity
IPM66_22630	COG0577	efflux transmembrane transporter activity
IPM66_22635	COG0577	efflux transmembrane transporter activity
IPM66_22635	COG1136	(ABC) transporter
IPM66_22655	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IPM66_22660	COG1595	DNA-templated transcription, initiation
IPM66_22675	COG1595	DNA-templated transcription, initiation
IPM66_22680	COG3386	PFAM SMP-30 Gluconolaconase
IPM66_22685	COG3193	protein, possibly involved in utilization of glycolate and propanediol
IPM66_22715	COG0783	Belongs to the Dps family
IPM66_22745	COG1136	(ABC) transporter
IPM66_22745	COG0577	efflux transmembrane transporter activity
IPM66_22755	COG0577	efflux transmembrane transporter activity
IPM66_22755	COG1136	(ABC) transporter
IPM66_22775	COG0246	Mannitol dehydrogenase
IPM66_22795	COG0189	ligase activity
IPM66_22805	COG0189	ligase activity
IPM66_22820	COG2072	flavoprotein involved in K transport
IPM66_22835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPM66_22835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IPM66_22840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPM66_22850	COG3119	arylsulfatase activity
IPM66_22860	COG0242	peptide deformylase activity
IPM66_22865	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IPM66_22870	COG0673	inositol 2-dehydrogenase activity
IPM66_22875	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_22880	COG3386	PFAM SMP-30 Gluconolaconase
IPM66_22885	COG0556	nucleotide-excision repair
IPM66_22900	COG3795	YCII-related domain
IPM66_22905	COG4941	Belongs to the sigma-70 factor family
IPM66_22915	COG0673	inositol 2-dehydrogenase activity
IPM66_22920	COG1904	glucuronate isomerase
IPM66_22925	COG0285	dihydrofolate synthase activity
IPM66_22930	COG5183	chlorophyll binding
IPM66_22930	COG2133	pyrroloquinoline quinone binding
IPM66_22940	COG3755	Protein conserved in bacteria
IPM66_22960	COG0681	Belongs to the peptidase S26 family
IPM66_22965	COG0367	asparagine synthase
IPM66_22970	COG0463	Glycosyl transferase, family 2
IPM66_22980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPM66_22985	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IPM66_22995	COG4956	integral membrane protein (PIN domain superfamily)
IPM66_23000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IPM66_23015	COG1744	ABC transporter substrate-binding protein PnrA-like
IPM66_23035	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IPM66_23035	COG5479	isomerase activity
IPM66_23040	COG3845	ABC transporter
IPM66_23065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPM66_23075	COG0768	penicillin binding
IPM66_23095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IPM66_23115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IPM66_23120	COG0584	glycerophosphoryl diester phosphodiesterase
IPM66_23125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM66_23155	COG1595	DNA-templated transcription, initiation
IPM66_23165	COG2062	phosphohistidine phosphatase, SixA
IPM66_23180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPM66_23185	COG4399	Belongs to the UPF0754 family
IPM66_23190	COG0824	Thioesterase
IPM66_23205	COG3494	Protein of unknown function (DUF1009)
IPM66_23210	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPM66_23215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IPM66_23220	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPM66_23240	COG0542	response to heat
IPM66_23245	COG1136	(ABC) transporter
IPM66_23255	COG0793	Belongs to the peptidase S41A family
IPM66_23270	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IPM66_23275	COG2226	methyltransferase
IPM66_23295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IPM66_23295	COG0646	methionine synthase
IPM66_23365	COG0596	Alpha beta hydrolase
IPM66_23400	COG3655	Transcriptional regulator
IPM66_23410	COG2339	peptidase activity
IPM66_23415	COG2208	phosphoserine phosphatase activity
IPM66_23415	COG2770	Histidine kinase
IPM66_23435	COG1716	ATPase activity
IPM66_23440	COG3710	Transcriptional regulator
IPM66_23440	COG0457	Tetratricopeptide repeat
IPM66_23470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IPM66_23485	COG1388	LysM domain
IPM66_23485	COG3942	CHAP domain
IPM66_23490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM66_23490	COG0515	serine threonine protein kinase
IPM66_23510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM66_23535	COG1484	DNA-dependent DNA replication
IPM66_23560	COG0438	transferase activity, transferring glycosyl groups
IPM66_23580	COG1228	amidohydrolase
IPM66_23615	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IPM66_23635	COG0247	lactate metabolic process
IPM66_23640	COG0277	FAD linked oxidase domain protein
IPM66_23645	COG0822	iron-sulfur transferase activity
IPM66_23665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IPM66_23685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IPM66_23695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IPM66_23700	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IPM66_23705	COG0193	aminoacyl-tRNA hydrolase activity
IPM66_23710	COG0360	Binds together with S18 to 16S ribosomal RNA
IPM66_23720	COG0359	binds to the 23S rRNA
IPM66_23725	COG0305	Participates in initiation and elongation during chromosome replication
IPM66_23730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IPM66_23745	COG0531	amino acid
IPM66_23755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPM66_23760	COG1472	Belongs to the glycosyl hydrolase 3 family
IPM66_23770	COG3384	dioxygenase
IPM66_23805	COG0745	RESPONSE REGULATOR receiver
IPM66_23810	COG5002	protein histidine kinase activity
IPM66_23825	COG2373	Large extracellular alpha-helical protein
IPM66_23835	COG2385	sporulation resulting in formation of a cellular spore
IPM66_23855	COG1032	radical SAM domain protein
IPM66_23865	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IPM66_23875	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IPM66_23880	COG0375	protein maturation
IPM66_23890	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IPM66_23895	COG0298	carbon dioxide binding
IPM66_23920	COG2183	response to ionizing radiation
IPM66_23925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPM66_23930	COG3875	lactate racemase activity
IPM66_23955	COG2226	methyltransferase
IPM66_23965	COG4948	Mandelate Racemase Muconate Lactonizing
IPM66_23970	COG0477	Major facilitator Superfamily
IPM66_23995	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IPM66_24000	COG0859	PFAM glycosyl transferase family 9
IPM66_24005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IPM66_24010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IPM66_24025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IPM66_24035	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IPM66_24040	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IPM66_24070	COG0515	serine threonine protein kinase
IPM66_24080	COG0564	pseudouridine synthase activity
IPM66_24095	COG0500	methyltransferase
IPM66_24115	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_24120	COG2226	methyltransferase
IPM66_24130	COG3275	phosphorelay sensor kinase activity
IPM66_24135	COG3279	Response regulator of the LytR AlgR family
IPM66_24140	COG2226	methyltransferase
IPM66_24145	COG4206	TonB-dependent receptor
IPM66_24165	COG2304	oxidoreductase activity
IPM66_24180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IPM66_24185	COG1333	cytochrome c biogenesis protein
IPM66_24190	COG0705	Rhomboid family
IPM66_24190	COG0457	Tetratricopeptide repeat
IPM66_24195	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPM66_24200	COG1024	Enoyl-CoA hydratase
IPM66_24205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IPM66_24210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPM66_24230	COG3275	phosphorelay sensor kinase activity
IPM66_24235	COG3279	Response regulator of the LytR AlgR family
IPM66_24240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IPM66_24250	COG3876	Protein conserved in bacteria
IPM66_24260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM66_24270	COG1404	Belongs to the peptidase S8 family
IPM66_24275	COG0784	Response regulator, receiver
IPM66_24275	COG0835	chemotaxis
IPM66_24290	COG0793	Belongs to the peptidase S41A family
IPM66_24305	COG1136	(ABC) transporter
IPM66_24350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM66_24365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IPM66_24370	COG0492	ferredoxin-NADP+ reductase activity
IPM66_24395	COG1185	polyribonucleotide nucleotidyltransferase activity
IPM66_24400	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IPM66_24405	COG0511	ligase activity, forming carbon-carbon bonds
IPM66_24410	COG0501	Belongs to the peptidase M48B family
IPM66_24415	COG0439	Biotin carboxylase
IPM66_24430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IPM66_24440	COG2815	serine threonine protein kinase
IPM66_24440	COG0515	serine threonine protein kinase
IPM66_24460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IPM66_24470	COG3119	arylsulfatase activity
IPM66_24485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPM66_24495	COG0631	protein serine/threonine phosphatase activity
IPM66_24515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPM66_24525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPM66_24540	COG0673	inositol 2-dehydrogenase activity
IPM66_24545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPM66_24565	COG0673	inositol 2-dehydrogenase activity
IPM66_24570	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IPM66_24575	COG0488	(ABC) transporter
IPM66_24580	COG0779	Required for maturation of 30S ribosomal subunits
IPM66_24585	COG0195	Participates in both transcription termination and antitermination
IPM66_24590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IPM66_24600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IPM66_24620	COG3344	reverse transcriptase
IPM66_24625	COG0363	glucosamine-6-phosphate deaminase activity
IPM66_24630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPM66_24635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IPM66_24645	COG0564	pseudouridine synthase activity
IPM66_24715	COG1454	alcohol dehydrogenase
IPM66_24745	COG0179	Fumarylacetoacetate (FAA) hydrolase
IPM66_24755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM66_24780	COG1858	cytochrome C peroxidase
IPM66_24800	COG1228	amidohydrolase
IPM66_24805	COG0010	Belongs to the arginase family
IPM66_24810	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IPM66_24825	COG2226	methyltransferase
IPM66_24835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IPM66_24840	COG0573	inorganic phosphate transmembrane transporter activity
IPM66_24845	COG0581	inorganic phosphate transmembrane transporter activity
IPM66_24850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IPM66_24855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IPM66_24875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPM66_24875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IPM66_24880	COG1304	FMN binding
IPM66_24890	COG1028	Short-chain dehydrogenase reductase Sdr
IPM66_24940	COG1477	protein flavinylation
IPM66_24945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM66_24950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IPM66_24955	COG1620	l-lactate permease
IPM66_24970	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPM66_24980	COG2208	phosphoserine phosphatase activity