locus-tag	class	description
ACP_0001	COG1556	Lactate utilization protein
ACP_0002	COG1139	Iron-sulfur cluster binding protein
ACP_0003	COG0247	lactate metabolic process
ACP_0010	COG3537	Alpha-1,2-mannosidase
ACP_0012	COG1566	PFAM secretion protein HlyD family protein
ACP_0015	COG3534	alpha-L-arabinofuranosidase
ACP_0018	COG0583	DNA-binding transcription factor activity
ACP_0024	COG1621	beta-fructofuranosidase activity
ACP_0025	COG2814	Major facilitator Superfamily
ACP_0028	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACP_0031	COG2706	6-phosphogluconolactonase activity
ACP_0034	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ACP_0036	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ACP_0039	COG1349	DNA-binding transcription factor activity
ACP_0043	COG2244	polysaccharide biosynthetic process
ACP_0049	COG3345	alpha-galactosidase
ACP_0055	COG1278	Cold shock
ACP_0056	COG0612	Peptidase, M16
ACP_0057	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACP_0059	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACP_0060	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ACP_0064	COG1085	galactose-1-phosphate uridylyltransferase
ACP_0065	COG1609	Transcriptional regulator
ACP_0072	COG3250	beta-galactosidase activity
ACP_0076	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ACP_0080	COG2205	protein histidine kinase activity
ACP_0081	COG2205	protein histidine kinase activity
ACP_0085	COG1606	tRNA processing
ACP_0086	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ACP_0087	COG1691	(AIR) carboxylase
ACP_0089	COG0538	isocitrate dehydrogenase activity
ACP_0090	COG0039	L-malate dehydrogenase activity
ACP_0096	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACP_0098	COG5001	Diguanylate cyclase
ACP_0098	COG4251	negative regulation of phosphorylation
ACP_0098	COG2203	Gaf domain
ACP_0098	COG3706	GGDEF domain
ACP_0102	COG1053	succinate dehydrogenase
ACP_0104	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACP_0108	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACP_0110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACP_0113	COG1132	(ABC) transporter
ACP_0114	COG0795	lipopolysaccharide-transporting ATPase activity
ACP_0120	COG0352	thiamine-phosphate diphosphorylase activity
ACP_0121	COG0531	amino acid
ACP_0122	COG0531	amino acid
ACP_0125	COG0205	6-phosphofructokinase activity
ACP_0128	COG0006	proline dipeptidase activity
ACP_0129	COG0511	ligase activity, forming carbon-carbon bonds
ACP_0131	COG0439	Biotin carboxylase
ACP_0133	COG0840	transmembrane signaling receptor activity
ACP_0134	COG1487	ribonuclease activity
ACP_0135	COG4456	Virulence-associated protein
ACP_0136	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACP_0137	COG1268	BioY protein
ACP_0139	COG1324	tolerance protein
ACP_0140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACP_0146	COG0412	Dienelactone hydrolase
ACP_0148	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACP_0149	COG1185	polyribonucleotide nucleotidyltransferase activity
ACP_0153	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACP_0155	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ACP_0157	COG3706	GGDEF domain
ACP_0158	COG0681	Belongs to the peptidase S26 family
ACP_0159	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACP_0160	COG2208	phosphoserine phosphatase activity
ACP_0160	COG2770	Histidine kinase
ACP_0162	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACP_0164	COG2200	EAL domain
ACP_0166	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACP_0170	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ACP_0171	COG3956	TIGRFAM MazG family protein
ACP_0173	COG4948	Mandelate Racemase Muconate Lactonizing
ACP_0176	COG1960	acyl-CoA dehydrogenase activity
ACP_0178	COG1127	ABC transporter
ACP_0179	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACP_0180	COG2204	response regulator
ACP_0181	COG5002	protein histidine kinase activity
ACP_0184	COG2815	serine threonine protein kinase
ACP_0184	COG0515	serine threonine protein kinase
ACP_0186	COG1643	Atp-dependent helicase
ACP_0194	COG0673	inositol 2-dehydrogenase activity
ACP_0197	COG0129	dihydroxy-acid dehydratase activity
ACP_0201	COG0702	epimerase
ACP_0202	COG4221	oxidoreductase activity
ACP_0203	COG1064	alcohol dehydrogenase
ACP_0206	COG0300	oxidoreductase activity
ACP_0209	COG0745	RESPONSE REGULATOR receiver
ACP_0209	COG3706	GGDEF domain
ACP_0213	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACP_0214	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACP_0221	COG0596	Alpha beta hydrolase
ACP_0228	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACP_0229	COG0083	homoserine kinase activity
ACP_0230	COG3118	belongs to the thioredoxin family
ACP_0231	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACP_0233	COG3604	Transcriptional regulator
ACP_0235	COG1558	bacterial-type flagellum-dependent cell motility
ACP_0236	COG1677	Flagellar hook-basal body complex protein FliE
ACP_0238	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACP_0240	COG1157	protein secretion by the type III secretion system
ACP_0244	COG1749	Flagellar hook protein flgE
ACP_0246	COG1338	Plays a role in the flagellum-specific transport system
ACP_0248	COG1684	flagellar biosynthetic protein fliR
ACP_0250	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACP_0251	COG1191	sigma factor activity
ACP_0252	COG1776	CheC inhibitor of MCP methylation
ACP_0252	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACP_0254	COG4786	Flagellar basal body rod
ACP_0255	COG4786	Flagellar basal body rod
ACP_0256	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ACP_0257	COG1706	bacterial-type flagellum-dependent cell motility
ACP_0261	COG1256	bacterial-type flagellum assembly
ACP_0266	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACP_0267	COG1331	Highly conserved protein containing a thioredoxin domain
ACP_0275	COG0534	Mate efflux family protein
ACP_0276	COG1959	2 iron, 2 sulfur cluster binding
ACP_0277	COG1692	metallophosphoesterase
ACP_0278	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACP_0282	COG0356	it plays a direct role in the translocation of protons across the membrane
ACP_0283	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACP_0284	COG1007	ATP synthesis coupled electron transport
ACP_0285	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_0287	COG0713	ATP synthesis coupled electron transport
ACP_0289	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACP_0294	COG0649	NAD binding
ACP_0295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_0296	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_0300	COG0148	phosphopyruvate hydratase activity
ACP_0302	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACP_0308	COG1132	(ABC) transporter
ACP_0310	COG3265	gluconokinase activity
ACP_0311	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ACP_0313	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ACP_0316	COG1609	Transcriptional regulator
ACP_0317	COG0460	homoserine dehydrogenase
ACP_0319	COG0667	Aldo Keto reductase
ACP_0320	COG3383	formate dehydrogenase (NAD+) activity
ACP_0321	COG2427	Protein of unknown function (DUF1641)
ACP_0322	COG1609	Transcriptional regulator
ACP_0327	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACP_0328	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACP_0328	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACP_0329	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACP_0337	COG3046	protein related to deoxyribodipyrimidine photolyase
ACP_0338	COG0644	oxidoreductase
ACP_0343	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACP_0346	COG0488	(ABC) transporter
ACP_0347	COG0488	(ABC) transporter
ACP_0356	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACP_0361	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACP_0362	COG1119	ATPase activity
ACP_0420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACP_0420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACP_0421	COG0436	Aminotransferase
ACP_0422	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACP_0429	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ACP_0431	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ACP_0441	COG4221	oxidoreductase activity
ACP_0446	COG2070	2-Nitropropane dioxygenase
ACP_0447	COG4191	Histidine kinase
ACP_0448	COG4566	intracellular signal transduction
ACP_0449	COG4566	intracellular signal transduction
ACP_0450	COG2801	Transposase and inactivated derivatives
ACP_0455	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACP_0456	COG2203	Gaf domain
ACP_0456	COG4251	negative regulation of phosphorylation
ACP_0456	COG5001	Diguanylate cyclase
ACP_0456	COG3706	GGDEF domain
ACP_0458	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ACP_0459	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ACP_0462	COG3706	GGDEF domain
ACP_0463	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACP_0467	COG1294	oxidase, subunit
ACP_0468	COG1271	oxidase subunit
ACP_0482	COG0612	Peptidase, M16
ACP_0486	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACP_0489	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACP_0490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACP_0491	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACP_0492	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACP_0493	COG0745	RESPONSE REGULATOR receiver
ACP_0496	COG2205	protein histidine kinase activity
ACP_0496	COG0784	Response regulator, receiver
ACP_0497	COG0784	Response regulator, receiver
ACP_0498	COG3852	Histidine kinase
ACP_0499	COG0673	inositol 2-dehydrogenase activity
ACP_0501	COG2885	chlorophyll binding
ACP_0502	COG0823	Involved in the tonB-independent uptake of proteins
ACP_0503	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ACP_0506	COG0497	DNA recombination
ACP_0511	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACP_0515	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACP_0517	COG2203	Gaf domain
ACP_0517	COG3706	GGDEF domain
ACP_0517	COG4251	negative regulation of phosphorylation
ACP_0517	COG5001	Diguanylate cyclase
ACP_0521	COG0217	transcriptional regulatory protein
ACP_0524	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_0526	COG0297	glycogen (starch) synthase activity
ACP_0528	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACP_0531	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACP_0532	COG3258	Cytochrome c
ACP_0534	COG2022	thiamine diphosphate biosynthetic process
ACP_0538	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ACP_0544	COG1278	Cold shock
ACP_0550	COG2755	lipolytic protein G-D-S-L family
ACP_0556	COG4952	isomerase
ACP_0558	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_0558	COG3347	Dehydrogenase
ACP_0559	COG1070	Carbohydrate kinase
ACP_0560	COG2755	lipolytic protein G-D-S-L family
ACP_0574	COG2755	lipolytic protein G-D-S-L family
ACP_0577	COG0028	Belongs to the TPP enzyme family
ACP_0578	COG1088	dTDP-glucose 4,6-dehydratase activity
ACP_0580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACP_0581	COG0463	Glycosyl transferase, family 2
ACP_0591	COG0751	glycine-tRNA ligase activity
ACP_0592	COG0752	glycyl-tRNA synthetase alpha subunit
ACP_0593	COG1381	Involved in DNA repair and RecF pathway recombination
ACP_0601	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACP_0602	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACP_0608	COG0077	Prephenate dehydratase
ACP_0608	COG1605	Chorismate mutase
ACP_0609	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACP_0611	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACP_0612	COG1573	uracil-dna glycosylase
ACP_0613	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACP_0616	COG0194	GDP metabolic process
ACP_0617	COG1561	YicC-like family, N-terminal region
ACP_0618	COG1132	(ABC) transporter
ACP_0619	COG1660	Displays ATPase and GTPase activities
ACP_0621	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ACP_0626	COG1174	glycine betaine transport
ACP_0627	COG0517	IMP dehydrogenase activity
ACP_0627	COG1125	glycine betaine transport
ACP_0629	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACP_0631	COG0126	phosphoglycerate kinase activity
ACP_0634	COG0149	triose-phosphate isomerase activity
ACP_0638	COG1253	flavin adenine dinucleotide binding
ACP_0642	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ACP_0654	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
ACP_0655	COG1431	PFAM Stem cell self-renewal protein Piwi
ACP_0660	COG5001	Diguanylate cyclase
ACP_0660	COG3300	MHYT domain
ACP_0668	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_0671	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACP_0671	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACP_0674	COG2132	Multicopper oxidase
ACP_0677	COG2204	response regulator
ACP_0678	COG3852	Histidine kinase
ACP_0680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACP_0681	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ACP_0683	COG1940	carbohydrate kinase activity
ACP_0684	COG1755	Isoprenylcysteine carboxyl methyltransferase
ACP_0685	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACP_0686	COG0505	Belongs to the CarA family
ACP_0688	COG0101	tRNA pseudouridine synthase activity
ACP_0696	COG1196	nuclear chromosome segregation
ACP_0698	COG1286	toxin biosynthetic process
ACP_0700	COG0546	phosphoglycolate phosphatase activity
ACP_0703	COG2203	Gaf domain
ACP_0703	COG2200	EAL domain
ACP_0703	COG2199	diguanylate cyclase activity
ACP_0706	COG0586	Pfam SNARE associated Golgi protein
ACP_0707	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACP_0710	COG1587	Uroporphyrinogen-III synthase
ACP_0711	COG0181	hydroxymethylbilane synthase activity
ACP_0712	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACP_0713	COG1333	cytochrome c biogenesis protein
ACP_0713	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACP_0716	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACP_0717	COG1472	Belongs to the glycosyl hydrolase 3 family
ACP_0719	COG4166	transmembrane transport
ACP_0720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACP_0721	COG0459	protein refolding
ACP_0725	COG0047	phosphoribosylformylglycinamidine synthase activity
ACP_0727	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_0733	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ACP_0742	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACP_0743	COG0436	Aminotransferase
ACP_0744	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACP_0744	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACP_0745	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACP_0746	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACP_0750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACP_0751	COG0438	transferase activity, transferring glycosyl groups
ACP_0759	COG3394	polysaccharide catabolic process
ACP_0760	COG3275	phosphorelay sensor kinase activity
ACP_0761	COG0438	transferase activity, transferring glycosyl groups
ACP_0763	COG2181	nitrate reductase activity
ACP_0763	COG0247	lactate metabolic process
ACP_0765	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACP_0768	COG0589	response to stress
ACP_0777	COG1518	maintenance of DNA repeat elements
ACP_0786	COG0477	Major facilitator Superfamily
ACP_0786	COG2814	Major facilitator Superfamily
ACP_0788	COG1940	carbohydrate kinase activity
ACP_0790	COG1686	Belongs to the peptidase S11 family
ACP_0794	COG1573	uracil-dna glycosylase
ACP_0797	COG0443	Heat shock 70 kDa protein
ACP_0799	COG2827	Endonuclease containing a URI domain
ACP_0801	COG0484	heat shock protein binding
ACP_0802	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACP_0804	COG0789	Transcriptional regulator
ACP_0809	COG0006	proline dipeptidase activity
ACP_0812	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ACP_0812	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACP_0813	COG1562	ergosterol biosynthetic process
ACP_0815	COG1063	alcohol dehydrogenase
ACP_0816	COG1063	alcohol dehydrogenase
ACP_0818	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACP_0825	COG1596	polysaccharide export
ACP_0833	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACP_0834	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACP_0837	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACP_0838	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACP_0839	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACP_0842	COG0366	Alpha amylase catalytic
ACP_0843	COG0366	Alpha amylase catalytic
ACP_0845	COG0463	Glycosyl transferase, family 2
ACP_0852	COG3420	alginic acid biosynthetic process
ACP_0855	COG0531	amino acid
ACP_0857	COG1349	DNA-binding transcription factor activity
ACP_0858	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACP_0859	COG2222	sugar isomerase
ACP_0861	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACP_0863	COG2183	response to ionizing radiation
ACP_0864	COG1874	Beta-galactosidase
ACP_0872	COG0577	efflux transmembrane transporter activity
ACP_0872	COG1136	(ABC) transporter
ACP_0874	COG0564	pseudouridine synthase activity
ACP_0875	COG1501	Belongs to the glycosyl hydrolase 31 family
ACP_0884	COG1136	(ABC) transporter
ACP_0890	COG0784	Response regulator, receiver
ACP_0891	COG4251	negative regulation of phosphorylation
ACP_0895	COG0577	efflux transmembrane transporter activity
ACP_0895	COG1136	(ABC) transporter
ACP_0897	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACP_0898	COG0302	gtp cyclohydrolase
ACP_0901	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACP_0903	COG0351	phosphomethylpyrimidine kinase
ACP_0904	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACP_0905	COG0284	orotidine-5'-phosphate decarboxylase activity
ACP_0906	COG0577	efflux transmembrane transporter activity
ACP_0906	COG1136	(ABC) transporter
ACP_0907	COG1136	(ABC) transporter
ACP_0907	COG0577	efflux transmembrane transporter activity
ACP_0909	COG1874	Beta-galactosidase
ACP_0913	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACP_0918	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_0919	COG0004	ammonium transporteR
ACP_0920	COG0347	Belongs to the P(II) protein family
ACP_0921	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACP_0927	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACP_0931	COG1074	ATP-dependent DNA helicase activity
ACP_0933	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACP_0934	COG5002	protein histidine kinase activity
ACP_0935	COG0745	RESPONSE REGULATOR receiver
ACP_0936	COG0745	RESPONSE REGULATOR receiver
ACP_0937	COG4191	Histidine kinase
ACP_0939	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACP_0942	COG0300	oxidoreductase activity
ACP_0944	COG0314	molybdopterin synthase activity
ACP_0947	COG0483	inositol monophosphate 1-phosphatase activity
ACP_0950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACP_0953	COG0109	protoheme IX farnesyltransferase activity
ACP_0956	COG2322	membrane
ACP_0960	COG0835	chemotaxis
ACP_0961	COG0840	transmembrane signaling receptor activity
ACP_0962	COG2198	Histidine kinase
ACP_0962	COG0643	Histidine kinase
ACP_0964	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ACP_0968	COG2201	protein-glutamate methylesterase activity
ACP_0970	COG0745	RESPONSE REGULATOR receiver
ACP_0975	COG1832	CoA-binding protein
ACP_0976	COG4232	protein-disulfide reductase activity
ACP_0977	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACP_0979	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACP_0981	COG0009	L-threonylcarbamoyladenylate synthase
ACP_0983	COG1836	PFAM Integral membrane protein DUF92
ACP_0986	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACP_0987	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ACP_0988	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACP_0990	COG0473	3-isopropylmalate dehydrogenase activity
ACP_0996	COG3546	catalase activity
ACP_1001	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ACP_1001	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACP_1002	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACP_1004	COG0646	methionine synthase
ACP_1004	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ACP_1005	COG1722	exodeoxyribonuclease VII activity
ACP_1006	COG0626	cystathionine gamma-synthase activity
ACP_1007	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACP_1009	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACP_1012	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACP_1013	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACP_1015	COG4702	Belongs to the UPF0303 family
ACP_1016	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACP_1017	COG1183	phosphatidylcholine synthase activity
ACP_1018	COG0688	phosphatidylethanolamine metabolic process
ACP_1020	COG0456	acetyltransferase
ACP_1022	COG0346	lactoylglutathione lyase activity
ACP_1025	COG1960	acyl-CoA dehydrogenase activity
ACP_1026	COG0631	protein serine/threonine phosphatase activity
ACP_1027	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACP_1028	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACP_1029	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACP_1030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACP_1031	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACP_1034	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACP_1035	COG1923	regulation of RNA biosynthetic process
ACP_1037	COG0166	Belongs to the GPI family
ACP_1038	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACP_1039	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ACP_1039	COG0662	Cupin 2, conserved barrel domain protein
ACP_1040	COG1482	cell wall glycoprotein biosynthetic process
ACP_1043	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACP_1044	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACP_1045	COG0367	asparagine synthase
ACP_1047	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACP_1047	COG1024	Enoyl-CoA hydratase
ACP_1049	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACP_1050	COG1595	DNA-templated transcription, initiation
ACP_1052	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACP_1056	COG1295	ribonuclease BN
ACP_1059	COG1408	metallophosphoesterase
ACP_1060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACP_1064	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACP_1065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACP_1068	COG0454	-acetyltransferase
ACP_1068	COG0456	acetyltransferase
ACP_1072	COG2197	response regulator
ACP_1073	COG4585	Histidine kinase
ACP_1075	COG1131	(ABC) transporter
ACP_1077	COG1695	Transcriptional regulator
ACP_1080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACP_1082	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACP_1083	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACP_1086	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACP_1087	COG0772	Belongs to the SEDS family
ACP_1088	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACP_1089	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACP_1090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACP_1091	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACP_1094	COG0275	rRNA processing
ACP_1095	COG2001	Belongs to the MraZ family
ACP_1099	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACP_1106	COG4964	Belongs to the GSP D family
ACP_1114	COG0519	Catalyzes the synthesis of GMP from XMP
ACP_1114	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACP_1117	COG0495	leucyl-tRNA aminoacylation
ACP_1118	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACP_1119	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ACP_1123	COG0676	glucose-6-phosphate 1-epimerase activity
ACP_1124	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACP_1125	COG0800	Aldolase
ACP_1126	COG4948	Mandelate Racemase Muconate Lactonizing
ACP_1128	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_1130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACP_1143	COG3534	alpha-L-arabinofuranosidase
ACP_1146	COG0297	glycogen (starch) synthase activity
ACP_1158	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACP_1161	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACP_1166	COG0529	Catalyzes the synthesis of activated sulfate
ACP_1170	COG1132	(ABC) transporter
ACP_1190	COG0629	single-stranded DNA binding
ACP_1191	COG4962	Type ii secretion system protein e
ACP_1199	COG2217	Heavy metal translocating P-type atpase
ACP_1200	COG0701	Predicted permease
ACP_1202	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACP_1203	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_1206	COG0640	Transcriptional regulator
ACP_1215	COG2132	Multicopper oxidase
ACP_1224	COG1475	DNA binding
ACP_1230	COG2608	mercury ion transmembrane transporter activity
ACP_1238	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACP_1239	COG1612	heme a metabolic process
ACP_1239	COG0109	protoheme IX farnesyltransferase activity
ACP_1243	COG0322	excinuclease ABC activity
ACP_1247	COG0631	protein serine/threonine phosphatase activity
ACP_1250	COG0174	glutamine synthetase
ACP_1251	COG0515	serine threonine protein kinase
ACP_1253	COG0475	glutathione-regulated potassium exporter activity
ACP_1255	COG0004	ammonium transporteR
ACP_1259	COG0745	RESPONSE REGULATOR receiver
ACP_1260	COG0642	Histidine kinase
ACP_1263	COG3250	beta-galactosidase activity
ACP_1264	COG0531	amino acid
ACP_1272	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACP_1276	COG3128	pkhd-type hydroxylase
ACP_1277	COG4774	siderophore transport
ACP_1280	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_1283	COG1902	pentaerythritol trinitrate reductase activity
ACP_1291	COG4585	Histidine kinase
ACP_1292	COG2197	response regulator
ACP_1294	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACP_1302	COG0745	RESPONSE REGULATOR receiver
ACP_1322	COG1012	belongs to the aldehyde dehydrogenase family
ACP_1324	COG2197	response regulator
ACP_1328	COG2801	Transposase and inactivated derivatives
ACP_1332	COG1595	DNA-templated transcription, initiation
ACP_1336	COG0506	proline dehydrogenase activity
ACP_1337	COG3706	GGDEF domain
ACP_1338	COG1597	lipid kinase activity
ACP_1339	COG0778	Nitroreductase
ACP_1341	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_1343	COG1538	Outer membrane efflux protein
ACP_1345	COG2814	Major facilitator Superfamily
ACP_1348	COG1349	DNA-binding transcription factor activity
ACP_1349	COG3142	Participates in the control of copper homeostasis
ACP_1352	COG1695	Transcriptional regulator
ACP_1360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACP_1360	COG0438	transferase activity, transferring glycosyl groups
ACP_1362	COG1569	PIN domain
ACP_1370	COG1136	(ABC) transporter
ACP_1372	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACP_1375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACP_1379	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACP_1386	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ACP_1387	COG0492	ferredoxin-NADP+ reductase activity
ACP_1389	COG0305	Participates in initiation and elongation during chromosome replication
ACP_1390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACP_1392	COG2040	homocysteine
ACP_1397	COG0577	efflux transmembrane transporter activity
ACP_1397	COG1136	(ABC) transporter
ACP_1399	COG3537	Alpha-1,2-mannosidase
ACP_1401	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACP_1403	COG1335	isochorismatase
ACP_1404	COG0477	Major facilitator Superfamily
ACP_1415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_1420	COG0596	Alpha beta hydrolase
ACP_1421	COG1309	transcriptional regulator
ACP_1422	COG0203	ribosomal protein L17
ACP_1423	COG0202	RNA polymerase activity
ACP_1424	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACP_1425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACP_1426	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACP_1427	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACP_1428	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACP_1430	COG0563	adenylate kinase activity
ACP_1432	COG0200	Binds to the 23S rRNA
ACP_1433	COG1841	ribosomal large subunit assembly
ACP_1434	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACP_1435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACP_1436	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACP_1437	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACP_1438	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACP_1439	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACP_1440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACP_1441	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACP_1442	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACP_1443	COG0255	Belongs to the universal ribosomal protein uL29 family
ACP_1444	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACP_1445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACP_1446	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACP_1447	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACP_1448	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACP_1449	COG0089	rRNA binding
ACP_1450	COG0088	Forms part of the polypeptide exit tunnel
ACP_1451	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACP_1452	COG0051	transcription antitermination factor activity, RNA binding
ACP_1453	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACP_1454	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACP_1455	COG0049	tRNA binding
ACP_1456	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACP_1458	COG4946	Tricorn protease homolog
ACP_1458	COG0823	Involved in the tonB-independent uptake of proteins
ACP_1458	COG1506	peptidase
ACP_1461	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACP_1462	COG0473	3-isopropylmalate dehydrogenase activity
ACP_1464	COG0527	aspartate kinase activity
ACP_1466	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACP_1467	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACP_1468	COG2171	N-acyltransferase activity
ACP_1469	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACP_1474	COG0784	Response regulator, receiver
ACP_1474	COG2205	protein histidine kinase activity
ACP_1474	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACP_1474	COG2198	Histidine kinase
ACP_1475	COG2197	response regulator
ACP_1478	COG4221	oxidoreductase activity
ACP_1479	COG0604	alcohol dehydrogenase
ACP_1479	COG3321	synthase
ACP_1479	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_1482	COG1131	(ABC) transporter
ACP_1483	COG0842	Transport permease protein
ACP_1485	COG5002	protein histidine kinase activity
ACP_1486	COG0492	ferredoxin-NADP+ reductase activity
ACP_1487	COG1027	Aspartate ammonia-lyase
ACP_1490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACP_1492	COG2091	lysine biosynthetic process via aminoadipic acid
ACP_1497	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACP_1498	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACP_1499	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACP_1509	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACP_1510	COG0628	permease
ACP_1514	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ACP_1516	COG2135	peptidase activity
ACP_1517	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACP_1519	COG0587	DNA-directed DNA polymerase activity
ACP_1522	COG0577	efflux transmembrane transporter activity
ACP_1522	COG1136	(ABC) transporter
ACP_1525	COG1695	Transcriptional regulator
ACP_1526	COG1136	(ABC) transporter
ACP_1526	COG0577	efflux transmembrane transporter activity
ACP_1527	COG1136	(ABC) transporter
ACP_1527	COG0577	efflux transmembrane transporter activity
ACP_1528	COG1136	(ABC) transporter
ACP_1528	COG0577	efflux transmembrane transporter activity
ACP_1533	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACP_1533	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACP_1536	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ACP_1538	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACP_1552	COG4555	ABC transporter
ACP_1567	COG1136	(ABC) transporter
ACP_1567	COG0577	efflux transmembrane transporter activity
ACP_1570	COG2801	Transposase and inactivated derivatives
ACP_1576	COG0589	response to stress
ACP_1586	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACP_1589	COG1733	regulation of RNA biosynthetic process
ACP_1601	COG1136	(ABC) transporter
ACP_1606	COG0859	PFAM glycosyl transferase family 9
ACP_1607	COG1663	tetraacyldisaccharide 4'-kinase activity
ACP_1608	COG1519	Transferase
ACP_1611	COG0750	zinc metalloprotease
ACP_1612	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACP_1613	COG0575	Belongs to the CDS family
ACP_1615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACP_1616	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACP_1617	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACP_1620	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ACP_1622	COG0494	nUDIX hydrolase
ACP_1623	COG1278	Cold shock
ACP_1624	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ACP_1624	COG1796	DNA polymerase
ACP_1626	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACP_1627	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACP_1628	COG0776	regulation of translation
ACP_1632	COG1131	(ABC) transporter
ACP_1634	COG1505	serine-type exopeptidase activity
ACP_1638	COG3852	Histidine kinase
ACP_1639	COG1501	Belongs to the glycosyl hydrolase 31 family
ACP_1642	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACP_1647	COG0482	sulfurtransferase activity
ACP_1648	COG1160	GTP binding
ACP_1651	COG1199	ATP-dependent helicase activity
ACP_1658	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACP_1661	COG1024	Enoyl-CoA hydratase
ACP_1664	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACP_1667	COG0640	Transcriptional regulator
ACP_1673	COG1530	ribonuclease E activity
ACP_1673	COG1530	ribonuclease E activity
ACP_1674	COG0772	Belongs to the SEDS family
ACP_1678	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACP_1684	COG0768	penicillin binding
ACP_1688	COG1012	belongs to the aldehyde dehydrogenase family
ACP_1690	COG0686	Belongs to the AlaDH PNT family
ACP_1692	COG5000	phosphorelay sensor kinase activity
ACP_1693	COG2204	response regulator
ACP_1697	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACP_1699	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACP_1701	COG1136	(ABC) transporter
ACP_1701	COG0577	efflux transmembrane transporter activity
ACP_1704	COG0668	transmembrane transport
ACP_1706	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACP_1707	COG0268	Binds directly to 16S ribosomal RNA
ACP_1710	COG0489	protein tyrosine kinase activity
ACP_1716	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACP_1717	COG1201	RNA secondary structure unwinding
ACP_1720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ACP_1723	COG0572	uridine kinase
ACP_1725	COG1215	transferase activity, transferring glycosyl groups
ACP_1727	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_1729	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ACP_1732	COG0745	RESPONSE REGULATOR receiver
ACP_1736	COG1570	exodeoxyribonuclease VII activity
ACP_1737	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACP_1738	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACP_1738	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACP_1739	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACP_1742	COG4152	abc transporter atp-binding protein
ACP_1743	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACP_1744	COG1945	arginine decarboxylase activity
ACP_1746	COG2957	Belongs to the agmatine deiminase family
ACP_1748	COG0590	tRNA wobble adenosine to inosine editing
ACP_1755	COG0792	nuclease activity
ACP_1764	COG1064	alcohol dehydrogenase
ACP_1767	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ACP_1769	COG0159	tryptophan synthase activity
ACP_1770	COG0133	tryptophan synthase activity
ACP_1771	COG0135	phosphoribosylanthranilate isomerase activity
ACP_1772	COG0134	indole-3-glycerol-phosphate synthase activity
ACP_1776	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACP_1777	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACP_1785	COG3852	Histidine kinase
ACP_1789	COG0372	Belongs to the citrate synthase family
ACP_1792	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_1793	COG0210	DNA helicase
ACP_1795	COG0531	amino acid
ACP_1801	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACP_1805	COG0175	sulfate reduction
ACP_1807	COG0251	oxidation-reduction process
ACP_1809	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACP_1811	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACP_1813	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACP_1815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACP_1816	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
ACP_1818	COG0358	DNA primase activity
ACP_1820	COG0367	asparagine synthase
ACP_1824	COG2234	aminopeptidase activity
ACP_1828	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACP_1830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACP_1830	COG0072	phenylalanine-tRNA ligase activity
ACP_1832	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ACP_1835	COG0564	pseudouridine synthase activity
ACP_1836	COG1764	response to oxidative stress
ACP_1838	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACP_1839	COG2081	HI0933 family
ACP_1845	COG0315	cyclic pyranopterin monophosphate synthase activity
ACP_1846	COG0303	'Molybdopterin
ACP_1848	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACP_1851	COG0659	secondary active sulfate transmembrane transporter activity
ACP_1852	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ACP_1853	COG1136	(ABC) transporter
ACP_1853	COG0577	efflux transmembrane transporter activity
ACP_1858	COG1032	radical SAM domain protein
ACP_1864	COG0154	amidase activity
ACP_1865	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACP_1876	COG1012	belongs to the aldehyde dehydrogenase family
ACP_1877	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ACP_1881	COG1295	ribonuclease BN
ACP_1883	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACP_1887	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACP_1893	COG1595	DNA-templated transcription, initiation
ACP_1894	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACP_1900	COG2271	Major facilitator Superfamily
ACP_1902	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACP_1905	COG0424	maF-like protein
ACP_1906	COG1446	asparaginase
ACP_1909	COG0315	cyclic pyranopterin monophosphate synthase activity
ACP_1909	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACP_1912	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACP_1916	COG0156	8-amino-7-oxononanoate synthase activity
ACP_1917	COG3590	peptidase
ACP_1923	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACP_1925	COG0416	fatty acid biosynthetic process
ACP_1926	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACP_1928	COG0277	FAD linked oxidase domain protein
ACP_1935	COG4095	Psort location CytoplasmicMembrane, score
ACP_1941	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACP_1943	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACP_1943	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACP_1944	COG1733	regulation of RNA biosynthetic process
ACP_1952	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACP_1952	COG0515	serine threonine protein kinase
ACP_1953	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ACP_1956	COG1476	TRANSCRIPTIONal
ACP_1958	COG1950	PFAM Membrane protein of
ACP_1961	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACP_1962	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACP_1964	COG2208	phosphoserine phosphatase activity
ACP_1964	COG2770	Histidine kinase
ACP_1967	COG1819	glycosyl
ACP_1970	COG5520	Belongs to the glycosyl hydrolase 30 family
ACP_1971	COG2814	Major facilitator Superfamily
ACP_1972	COG3852	Histidine kinase
ACP_1973	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ACP_1974	COG0726	polysaccharide deacetylase
ACP_1975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACP_1976	COG0237	dephospho-CoA kinase activity
ACP_1977	COG2835	tetraacyldisaccharide 4'-kinase activity
ACP_1979	COG0693	protein deglycase activity
ACP_1980	COG0606	chelatase, subunit chli
ACP_1989	COG1595	DNA-templated transcription, initiation
ACP_1993	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACP_2002	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACP_2003	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACP_2006	COG0577	efflux transmembrane transporter activity
ACP_2006	COG1136	(ABC) transporter
ACP_2007	COG0577	efflux transmembrane transporter activity
ACP_2007	COG1136	(ABC) transporter
ACP_2011	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACP_2012	COG0540	Belongs to the ATCase OTCase family
ACP_2013	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACP_2014	COG0557	exoribonuclease II activity
ACP_2016	COG1902	pentaerythritol trinitrate reductase activity
ACP_2020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACP_2023	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
ACP_2025	COG0151	Belongs to the GarS family
ACP_2030	COG0776	regulation of translation
ACP_2035	COG1201	RNA secondary structure unwinding
ACP_2036	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACP_2037	COG0571	ribonuclease III activity
ACP_2038	COG0681	Belongs to the peptidase S26 family
ACP_2039	COG0681	Belongs to the peptidase S26 family
ACP_2042	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACP_2049	COG3279	Response regulator of the LytR AlgR family
ACP_2054	COG0632	four-way junction helicase activity
ACP_2058	COG1040	competence protein
ACP_2061	COG1297	OPT oligopeptide transporter protein
ACP_2062	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACP_2063	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACP_2064	COG0359	binds to the 23S rRNA
ACP_2065	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACP_2066	COG0360	Binds together with S18 to 16S ribosomal RNA
ACP_2067	COG0193	aminoacyl-tRNA hydrolase activity
ACP_2068	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACP_2069	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACP_2071	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACP_2074	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACP_2075	COG0537	adenosine 5'-monophosphoramidase activity
ACP_2077	COG0012	GTP binding
ACP_2079	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACP_2080	COG2255	four-way junction helicase activity
ACP_2081	COG5001	Diguanylate cyclase
ACP_2083	COG3177	Filamentation induced by cAMP protein fic
ACP_2086	COG1420	regulation of RNA biosynthetic process
ACP_2087	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACP_2088	COG0484	heat shock protein binding
ACP_2091	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACP_2093	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACP_2096	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACP_2097	COG0509	glycine decarboxylation via glycine cleavage system
ACP_2098	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACP_2099	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACP_2110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACP_2112	COG4585	Histidine kinase
ACP_2113	COG2197	response regulator
ACP_2117	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
ACP_2117	COG0706	membrane insertase activity
ACP_2119	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACP_2120	COG0594	ribonuclease P activity
ACP_2123	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACP_2125	COG0577	efflux transmembrane transporter activity
ACP_2125	COG1136	(ABC) transporter
ACP_2130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACP_2130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACP_2132	COG0673	inositol 2-dehydrogenase activity
ACP_2133	COG4770	biotin carboxylase activity
ACP_2134	COG0439	Biotin carboxylase
ACP_2140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACP_2141	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACP_2142	COG1862	Preprotein translocase
ACP_2145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACP_2149	COG0657	acetylesterase activity
ACP_2149	COG2755	lipolytic protein G-D-S-L family
ACP_2154	COG0343	queuine tRNA-ribosyltransferase activity
ACP_2159	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACP_2160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACP_2161	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ACP_2162	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACP_2164	COG1192	Involved in chromosome partitioning
ACP_2169	COG0285	dihydrofolate synthase activity
ACP_2171	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACP_2172	COG0357	Ribosomal RNA small subunit methyltransferase G
ACP_2173	COG1192	Involved in chromosome partitioning
ACP_2174	COG1475	DNA binding
ACP_2183	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACP_2186	COG3609	addiction module antidote protein, CC2985 family
ACP_2188	COG0113	porphobilinogen synthase activity
ACP_2190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACP_2191	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACP_2196	COG0592	DNA-directed DNA polymerase activity
ACP_2197	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ACP_2198	COG4191	Histidine kinase
ACP_2201	COG2855	membrane
ACP_2202	COG0583	DNA-binding transcription factor activity
ACP_2204	COG0017	Asparaginyl-tRNA synthetase
ACP_2207	COG3093	addiction module antidote protein HigA
ACP_2209	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACP_2214	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACP_2218	COG0475	glutathione-regulated potassium exporter activity
ACP_2219	COG0697	spore germination
ACP_2220	COG0215	cysteine-tRNA ligase activity
ACP_2221	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACP_2223	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACP_2225	COG0300	oxidoreductase activity
ACP_2227	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACP_2233	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACP_2235	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ACP_2243	COG2226	methyltransferase
ACP_2244	COG1366	Belongs to the anti-sigma-factor antagonist family
ACP_2247	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACP_2248	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACP_2249	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACP_2250	COG2027	D-alanyl-D-alanine carboxypeptidase
ACP_2252	COG1428	Deoxynucleoside kinase
ACP_2254	COG0745	RESPONSE REGULATOR receiver
ACP_2257	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACP_2260	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACP_2261	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACP_2265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACP_2267	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ACP_2268	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACP_2271	COG1193	negative regulation of DNA recombination
ACP_2277	COG0698	ribose 5-phosphate isomerase
ACP_2279	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACP_2280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACP_2281	COG0363	glucosamine-6-phosphate deaminase activity
ACP_2282	COG0837	glucose binding
ACP_2283	COG3781	membrane
ACP_2287	COG2094	Belongs to the DNA glycosylase MPG family
ACP_2288	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACP_2290	COG1538	Outer membrane efflux protein
ACP_2293	COG0058	SHG alpha-glucan phosphorylase activity
ACP_2294	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACP_2295	COG0076	glutamate decarboxylase activity
ACP_2296	COG1278	Cold shock
ACP_2297	COG3590	peptidase
ACP_2299	COG1215	transferase activity, transferring glycosyl groups
ACP_2302	COG1012	belongs to the aldehyde dehydrogenase family
ACP_2305	COG1872	DUF167
ACP_2306	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACP_2307	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACP_2311	COG1760	l-serine dehydratase
ACP_2314	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACP_2315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACP_2317	COG0539	negative regulation of cytoplasmic translation
ACP_2319	COG2080	2 iron, 2 sulfur cluster binding
ACP_2320	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACP_2321	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACP_2323	COG0746	molybdenum cofactor guanylyltransferase activity
ACP_2325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACP_2327	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACP_2328	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACP_2329	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACP_2330	COG1024	Enoyl-CoA hydratase
ACP_2333	COG0277	FAD linked oxidase domain protein
ACP_2333	COG0247	lactate metabolic process
ACP_2335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACP_2336	COG0107	imidazoleglycerol-phosphate synthase activity
ACP_2337	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACP_2338	COG0131	Imidazoleglycerol-phosphate dehydratase
ACP_2339	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACP_2340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACP_2341	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACP_2342	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACP_2343	COG0745	RESPONSE REGULATOR receiver
ACP_2343	COG4191	Histidine kinase
ACP_2343	COG2205	protein histidine kinase activity
ACP_2344	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACP_2346	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACP_2348	COG0124	histidyl-tRNA synthetase
ACP_2349	COG0445	tRNA wobble uridine modification
ACP_2350	COG0513	Belongs to the DEAD box helicase family
ACP_2353	COG0025	NhaP-type Na H and K H
ACP_2354	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACP_2355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACP_2356	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACP_2381	COG0352	thiamine-phosphate diphosphorylase activity
ACP_2383	COG0535	radical SAM domain protein
ACP_2389	COG0328	RNA-DNA hybrid ribonuclease activity
ACP_2389	COG0406	alpha-ribazole phosphatase activity
ACP_2390	COG1610	YqeY-like protein
ACP_2391	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACP_2392	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACP_2396	COG1968	undecaprenyl-diphosphatase activity
ACP_2397	COG1960	acyl-CoA dehydrogenase activity
ACP_2403	COG3258	Cytochrome c
ACP_2407	COG0542	response to heat
ACP_2409	COG0038	chloride channel
ACP_2412	COG1472	Belongs to the glycosyl hydrolase 3 family
ACP_2414	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACP_2415	COG1472	Belongs to the glycosyl hydrolase 3 family
ACP_2417	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ACP_2418	COG0243	molybdopterin cofactor binding
ACP_2419	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACP_2424	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACP_2427	COG1611	Belongs to the LOG family
ACP_2429	COG3250	beta-galactosidase activity
ACP_2430	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACP_2431	COG4946	Tricorn protease homolog
ACP_2431	COG0823	Involved in the tonB-independent uptake of proteins
ACP_2431	COG1506	peptidase
ACP_2432	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACP_2433	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACP_2435	COG1565	acr, cog1565
ACP_2435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACP_2443	COG2314	TM2 domain
ACP_2453	COG0504	CTP synthase activity
ACP_2455	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACP_2458	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_2459	COG2169	Transcriptional regulator
ACP_2459	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACP_2461	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACP_2462	COG0163	prenyltransferase activity
ACP_2464	COG0825	malonyl-CoA metabolic process
ACP_2465	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_2466	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACP_2474	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACP_2475	COG2095	MarC family integral membrane protein
ACP_2495	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACP_2497	COG1725	Transcriptional regulator
ACP_2498	COG1131	(ABC) transporter
ACP_2502	COG1136	(ABC) transporter
ACP_2502	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACP_2504	COG0577	efflux transmembrane transporter activity
ACP_2504	COG1136	(ABC) transporter
ACP_2506	COG2204	response regulator
ACP_2507	COG4191	Histidine kinase
ACP_2509	COG0577	efflux transmembrane transporter activity
ACP_2510	COG1136	(ABC) transporter
ACP_2510	COG0577	efflux transmembrane transporter activity
ACP_2515	COG0366	Alpha amylase catalytic
ACP_2516	COG1764	response to oxidative stress
ACP_2520	COG0366	Alpha amylase catalytic
ACP_2521	COG0667	Aldo Keto reductase
ACP_2530	COG2814	Major facilitator Superfamily
ACP_2532	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_2533	COG1136	(ABC) transporter
ACP_2535	COG0071	Belongs to the small heat shock protein (HSP20) family
ACP_2541	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACP_2543	COG1959	2 iron, 2 sulfur cluster binding
ACP_2544	COG1104	cysteine desulfurase activity
ACP_2546	COG0316	Belongs to the HesB IscA family
ACP_2547	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACP_2548	COG1942	4-Oxalocrotonate Tautomerase
ACP_2549	COG0443	Heat shock 70 kDa protein
ACP_2550	COG0633	Ferredoxin
ACP_2551	COG2975	iron-sulfur cluster assembly
ACP_2557	COG0450	alkyl hydroperoxide reductase
ACP_2560	COG1136	(ABC) transporter
ACP_2563	COG3657	addiction module killer protein
ACP_2565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_2566	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_2568	COG0649	NAD binding
ACP_2570	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACP_2573	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACP_2574	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_2576	COG1007	ATP synthesis coupled electron transport
ACP_2577	COG1234	tRNA 3'-trailer cleavage
ACP_2580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACP_2583	COG0525	valine-tRNA ligase activity
ACP_2585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACP_2589	COG1187	pseudouridine synthase activity
ACP_2590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACP_2592	COG0180	Tryptophanyl-tRNA synthetase
ACP_2594	COG1994	Peptidase M50
ACP_2595	COG0662	Cupin 2, conserved barrel domain protein
ACP_2598	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACP_2600	COG4964	Belongs to the GSP D family
ACP_2609	COG2801	Transposase and inactivated derivatives
ACP_2612	COG0045	succinate-CoA ligase (ADP-forming) activity
ACP_2614	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACP_2617	COG0105	UTP biosynthetic process
ACP_2619	COG0667	Aldo Keto reductase
ACP_2624	COG0322	excinuclease ABC activity
ACP_2625	COG0312	modulator of DNA gyrase
ACP_2626	COG0312	modulator of DNA gyrase
ACP_2627	COG2318	DinB family
ACP_2630	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ACP_2635	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACP_2636	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACP_2637	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACP_2638	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACP_2640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACP_2642	COG1388	LysM domain
ACP_2642	COG0741	lytic transglycosylase activity
ACP_2643	COG0481	GTPase activity
ACP_2646	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACP_2648	COG1136	(ABC) transporter
ACP_2648	COG0577	efflux transmembrane transporter activity
ACP_2649	COG2309	aminopeptidase activity
ACP_2650	COG2890	protein-(glutamine-N5) methyltransferase activity
ACP_2651	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACP_2652	COG1793	dna ligase
ACP_2656	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACP_2657	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACP_2666	COG1914	H( )-stimulated, divalent metal cation uptake system
ACP_2667	COG1321	iron dependent repressor
ACP_2674	COG3220	belongs to the UPF0276 family
ACP_2678	COG2186	Transcriptional regulator
ACP_2680	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_2684	COG2271	Major facilitator Superfamily
ACP_2685	COG1904	glucuronate isomerase
ACP_2686	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ACP_2686	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACP_2686	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACP_2686	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACP_2689	COG0515	serine threonine protein kinase
ACP_2689	COG2815	serine threonine protein kinase
ACP_2691	COG0745	RESPONSE REGULATOR receiver
ACP_2694	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACP_2695	COG3258	Cytochrome c
ACP_2696	COG0602	queuosine metabolic process
ACP_2697	COG0720	synthase
ACP_2703	COG3064	Membrane
ACP_2704	COG1022	Amp-dependent synthetase and ligase
ACP_2706	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ACP_2709	COG1012	belongs to the aldehyde dehydrogenase family
ACP_2713	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACP_2714	COG1360	Flagellar Motor Protein
ACP_2716	COG2208	phosphoserine phosphatase activity
ACP_2718	COG3511	phospholipase C
ACP_2722	COG1858	cytochrome C peroxidase
ACP_2725	COG3511	phospholipase C
ACP_2728	COG1045	serine acetyltransferase
ACP_2729	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACP_2731	COG3459	Glycosyltransferase 36 associated
ACP_2737	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACP_2742	COG0187	DNA topoisomerase II activity
ACP_2746	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACP_2747	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACP_2753	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ACP_2754	COG4191	Histidine kinase
ACP_2756	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACP_2760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACP_2763	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACP_2765	COG0542	response to heat
ACP_2766	COG1136	(ABC) transporter
ACP_2781	COG1138	Cytochrome C-type biogenesis protein
ACP_2784	COG1506	peptidase
ACP_2784	COG0823	Involved in the tonB-independent uptake of proteins
ACP_2785	COG0546	phosphoglycolate phosphatase activity
ACP_2786	COG0556	nucleotide-excision repair
ACP_2787	COG1069	ribulokinase activity
ACP_2794	COG1609	Transcriptional regulator
ACP_2796	COG1063	alcohol dehydrogenase
ACP_2801	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACP_2802	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACP_2803	COG0335	large ribosomal subunit rRNA binding
ACP_2806	COG0336	Belongs to the RNA methyltransferase TrmD family
ACP_2807	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACP_2808	COG1837	Belongs to the UPF0109 family
ACP_2809	COG0228	four-way junction DNA binding
ACP_2810	COG5002	protein histidine kinase activity
ACP_2811	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACP_2812	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACP_2813	COG2814	Major facilitator Superfamily
ACP_2817	COG0667	Aldo Keto reductase
ACP_2818	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACP_2819	COG0183	Belongs to the thiolase family
ACP_2820	COG1960	acyl-CoA dehydrogenase activity
ACP_2824	COG3684	Belongs to the aldolase LacD family
ACP_2825	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACP_2828	COG2204	response regulator
ACP_2831	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACP_2832	COG0442	prolyl-tRNA aminoacylation
ACP_2834	COG0824	Thioesterase
ACP_2837	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACP_2837	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACP_2838	COG0745	RESPONSE REGULATOR receiver
ACP_2839	COG0142	geranyltranstransferase activity
ACP_2840	COG1666	GTP binding
ACP_2841	COG0084	hydrolase, TatD family'
ACP_2843	COG0018	arginyl-trna synthetase
ACP_2846	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACP_2849	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACP_2851	COG0501	Belongs to the peptidase M48B family
ACP_2852	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACP_2857	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACP_2861	COG0321	lipoyl(octanoyl) transferase activity
ACP_2863	COG2205	protein histidine kinase activity
ACP_2864	COG3158	transport of potassium into the cell
ACP_2868	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ACP_2871	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACP_2872	COG1254	Belongs to the acylphosphatase family
ACP_2876	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACP_2879	COG0512	Glutamine amidotransferase of anthranilate synthase
ACP_2883	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACP_2892	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACP_2901	COG0778	Nitroreductase
ACP_2904	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACP_2906	COG0742	ribosomal rna small subunit methyltransferase
ACP_2908	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACP_2909	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACP_2910	COG0739	heme binding
ACP_2919	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACP_2920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACP_2924	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACP_2925	COG0081	regulation of translation
ACP_2926	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACP_2927	COG0222	ribosome binding
ACP_2928	COG0085	RNA polymerase activity
ACP_2929	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACP_2931	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACP_2932	COG0667	Aldo Keto reductase
ACP_2936	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACP_2942	COG1309	transcriptional regulator
ACP_2943	COG2814	Major facilitator Superfamily
ACP_2944	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACP_2945	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACP_2946	COG0052	Belongs to the universal ribosomal protein uS2 family
ACP_2947	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACP_2948	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACP_2949	COG0528	UMP kinase activity
ACP_2953	COG3590	peptidase
ACP_2957	COG1472	Belongs to the glycosyl hydrolase 3 family
ACP_2959	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACP_2960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACP_2964	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACP_2965	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ACP_2967	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACP_2968	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACP_2970	COG0167	dihydroorotate dehydrogenase activity
ACP_2971	COG1877	trehalose-phosphatase activity
ACP_2972	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACP_2976	COG2239	Acts as a magnesium transporter
ACP_2978	COG0494	nUDIX hydrolase
ACP_2981	COG4974	Belongs to the 'phage' integrase family
ACP_2983	COG0653	protein targeting
ACP_2985	COG0009	L-threonylcarbamoyladenylate synthase
ACP_2987	COG0470	DNA polymerase III
ACP_2988	COG2124	cytochrome p450
ACP_2989	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACP_2991	COG0165	Argininosuccinate lyase
ACP_2992	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACP_2993	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACP_2994	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACP_2995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACP_2996	COG1438	arginine binding
ACP_2997	COG0069	glutamate synthase activity
ACP_2997	COG0070	glutamate synthase
ACP_2997	COG0067	glutamate synthase
ACP_3004	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACP_3006	COG1704	LemA family
ACP_3008	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACP_3012	COG0726	polysaccharide deacetylase
ACP_3015	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_3016	COG3387	PFAM Glycoside hydrolase 15-related
ACP_3017	COG0730	response to heat
ACP_3018	COG1648	precorrin-2 dehydrogenase activity
ACP_3018	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACP_3020	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACP_3026	COG2986	histidine ammonia-lyase
ACP_3028	COG0076	glutamate decarboxylase activity
ACP_3033	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_3036	COG0477	Major facilitator Superfamily
ACP_3039	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACP_3043	COG0450	alkyl hydroperoxide reductase
ACP_3044	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACP_3048	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACP_3049	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACP_3050	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACP_3053	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ACP_3054	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
ACP_3055	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ACP_3056	COG0375	protein maturation
ACP_3057	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACP_3060	COG0298	carbon dioxide binding
ACP_3061	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ACP_3064	COG2814	Major facilitator Superfamily
ACP_3068	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACP_3071	COG0488	(ABC) transporter
ACP_3077	COG1846	Transcriptional regulator
ACP_3079	COG1741	Belongs to the pirin family
ACP_3082	COG0254	rRNA binding
ACP_3084	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACP_3090	COG0028	Belongs to the TPP enzyme family
ACP_3095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACP_3096	COG0137	argininosuccinate synthase activity
ACP_3097	COG2755	lipolytic protein G-D-S-L family
ACP_3098	COG1309	transcriptional regulator
ACP_3099	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACP_3110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACP_3111	COG1459	type II secretion system
ACP_3115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACP_3117	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACP_3118	COG1278	Cold shock
ACP_3119	COG1295	ribonuclease BN
ACP_3120	COG2208	phosphoserine phosphatase activity
ACP_3120	COG2770	Histidine kinase
ACP_3123	COG0793	Belongs to the peptidase S41A family
ACP_3125	COG3481	metal-dependent phosphohydrolase, HD sub domain
ACP_3127	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACP_3128	COG0242	peptide deformylase activity
ACP_3129	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACP_3130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACP_3130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACP_3133	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACP_3134	COG2226	methyltransferase
ACP_3135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACP_3136	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACP_3137	COG1335	isochorismatase
ACP_3138	COG3384	dioxygenase
ACP_3143	COG0805	protein transport
ACP_3144	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACP_3145	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACP_3149	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACP_3152	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACP_3156	COG0022	dehydrogenase e1 component
ACP_3157	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ACP_3158	COG0668	transmembrane transport
ACP_3159	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACP_3159	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACP_3160	COG0802	atpase or kinase
ACP_3161	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACP_3163	COG0582	viral genome integration into host DNA
ACP_3164	COG0583	DNA-binding transcription factor activity
ACP_3167	COG3451	type IV secretory pathway VirB4
ACP_3174	COG1396	sequence-specific DNA binding
ACP_3176	COG4962	Type ii secretion system protein e
ACP_3187	COG1104	cysteine desulfurase activity
ACP_3196	COG1475	DNA binding
ACP_3199	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACP_3213	COG0577	efflux transmembrane transporter activity
ACP_3214	COG3344	reverse transcriptase
ACP_3222	COG0367	asparagine synthase
ACP_3244	COG0210	DNA helicase
ACP_3253	COG4962	Type ii secretion system protein e
ACP_3261	COG3451	type IV secretory pathway VirB4
ACP_3270	COG1569	PIN domain
ACP_3271	COG3311	Transcriptional regulator
ACP_3272	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACP_3279	COG0738	Major facilitator superfamily
ACP_3280	COG1063	alcohol dehydrogenase
ACP_3284	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACP_3285	COG2721	sulfolactate sulfo-lyase activity
ACP_3286	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_3287	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_3289	COG1305	Transglutaminase-like
ACP_3291	COG2308	Evidence 4 Homologs of previously reported genes of
ACP_3294	COG0590	tRNA wobble adenosine to inosine editing
ACP_3297	COG0138	bifunctional purine biosynthesis protein purh
ACP_3299	COG1476	TRANSCRIPTIONal
ACP_3300	COG0412	Dienelactone hydrolase
ACP_3303	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_3304	COG3548	integral membrane protein
ACP_3305	COG3361	conserved protein (COG2071)
ACP_3307	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACP_3308	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACP_3310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACP_3311	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ACP_3313	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACP_3315	COG0517	IMP dehydrogenase activity
ACP_3315	COG0516	GMP reductase activity
ACP_3316	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACP_3318	COG3186	Phenylalanine-4-hydroxylase
ACP_3319	COG1733	regulation of RNA biosynthetic process
ACP_3320	COG0702	epimerase
ACP_3322	COG2272	Belongs to the type-B carboxylesterase lipase family
ACP_3325	COG0779	Required for maturation of 30S ribosomal subunits
ACP_3326	COG0195	Participates in both transcription termination and antitermination
ACP_3327	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACP_3328	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACP_3329	COG1657	PFAM Prenyltransferase squalene oxidase
ACP_3334	COG0776	regulation of translation
ACP_3335	COG0717	Belongs to the dCTP deaminase family
ACP_3337	COG1410	methionine synthase
ACP_3337	COG0646	methionine synthase
ACP_3338	COG1648	precorrin-2 dehydrogenase activity
ACP_3338	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACP_3340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACP_3345	COG3409	Peptidoglycan-binding domain 1 protein
ACP_3345	COG0793	Belongs to the peptidase S41A family
ACP_3346	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACP_3347	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACP_3347	COG2755	lipolytic protein G-D-S-L family
ACP_3351	COG1393	Belongs to the ArsC family
ACP_3352	COG0196	riboflavin kinase activity
ACP_3353	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACP_3353	COG0321	lipoyl(octanoyl) transferase activity
ACP_3355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACP_3357	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACP_3362	COG1619	proteins homologs of microcin C7 resistance protein MccF
ACP_3363	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACP_3367	COG0330	HflC and HflK could
ACP_3368	COG1030	water channel activity
ACP_3373	COG0492	ferredoxin-NADP+ reductase activity
ACP_3390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ACP_3395	COG0756	dUTP diphosphatase activity
ACP_3397	COG1028	Short-chain dehydrogenase reductase Sdr
ACP_3405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACP_3409	COG1546	Belongs to the CinA family
ACP_3409	COG1058	Belongs to the CinA family
ACP_3410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACP_3411	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACP_3412	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACP_3413	COG0552	protein localization to endoplasmic reticulum
ACP_3414	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACP_3414	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACP_3418	COG0758	DNA mediated transformation
ACP_3419	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACP_3420	COG3077	Addiction module antitoxin, RelB DinJ family
ACP_3431	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACP_3432	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACP_3433	COG0740	serine-type endopeptidase activity
ACP_3434	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACP_3435	COG3263	regulation of cellular component size
ACP_3437	COG2814	Major facilitator Superfamily
ACP_3440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACP_3441	COG0640	Transcriptional regulator
ACP_3443	COG0798	PFAM Bile acid sodium symporter
ACP_3446	COG2062	phosphohistidine phosphatase, SixA
ACP_3447	COG0248	Ppx GppA phosphatase
ACP_3448	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACP_3449	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ACP_3452	COG1566	PFAM secretion protein HlyD family protein
ACP_3453	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACP_3455	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACP_3456	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACP_3458	COG1560	Kdo2-lipid A biosynthetic process
ACP_3459	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACP_3461	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACP_3462	COG3852	Histidine kinase
ACP_3464	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACP_3465	COG0440	acetolactate synthase activity
ACP_3466	COG0028	Belongs to the TPP enzyme family
ACP_3467	COG0129	dihydroxy-acid dehydratase activity
ACP_3468	COG0066	3-isopropylmalate dehydratase activity
ACP_3469	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACP_3470	COG0473	3-isopropylmalate dehydrogenase activity
ACP_3471	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACP_3472	COG0583	DNA-binding transcription factor activity
ACP_3480	COG1193	negative regulation of DNA recombination
ACP_3481	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACP_3482	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACP_3483	COG1012	belongs to the aldehyde dehydrogenase family
ACP_3488	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACP_3490	COG1132	(ABC) transporter
ACP_3491	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACP_3496	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACP_3505	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ACP_3514	COG0577	efflux transmembrane transporter activity
ACP_3514	COG1136	(ABC) transporter
ACP_3518	COG1505	serine-type exopeptidase activity
ACP_3520	COG0531	amino acid
ACP_3522	COG4774	siderophore transport
ACP_3523	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ACP_3536	COG2197	response regulator
ACP_3537	COG4585	Histidine kinase
ACP_3542	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACP_3545	COG0746	molybdenum cofactor guanylyltransferase activity
ACP_3546	COG1127	ABC transporter