locus-tag	class	description
H7849_00010	COG0183	Belongs to the thiolase family
H7849_00020	COG1760	l-serine dehydratase
H7849_00025	COG0606	chelatase, subunit chli
H7849_00030	COG0543	2 iron, 2 sulfur cluster binding
H7849_00030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7849_00035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7849_00045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7849_00055	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7849_00060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7849_00070	COG0681	Belongs to the peptidase S26 family
H7849_00075	COG0681	Belongs to the peptidase S26 family
H7849_00080	COG0571	ribonuclease III activity
H7849_00100	COG0667	Aldo Keto reductase
H7849_00105	COG0693	protein deglycase activity
H7849_00115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7849_00135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7849_00140	COG2204	response regulator
H7849_00145	COG5000	phosphorelay sensor kinase activity
H7849_00155	COG0686	Belongs to the AlaDH PNT family
H7849_00160	COG1012	belongs to the aldehyde dehydrogenase family
H7849_00165	COG1077	Cell shape determining protein MreB Mrl
H7849_00190	COG0772	Belongs to the SEDS family
H7849_00195	COG1530	ribonuclease E activity
H7849_00195	COG1530	ribonuclease E activity
H7849_00210	COG2226	methyltransferase
H7849_00220	COG0006	proline dipeptidase activity
H7849_00230	COG1215	transferase activity, transferring glycosyl groups
H7849_00235	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H7849_00260	COG0492	ferredoxin-NADP+ reductase activity
H7849_00265	COG4191	Histidine kinase
H7849_00280	COG1064	alcohol dehydrogenase
H7849_00290	COG2084	Dehydrogenase
H7849_00310	COG2197	response regulator
H7849_00330	COG1674	ftsk spoiiie
H7849_00335	COG1968	undecaprenyl-diphosphatase activity
H7849_00365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H7849_00370	COG2171	N-acyltransferase activity
H7849_00380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7849_00385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7849_00390	COG0527	aspartate kinase activity
H7849_00405	COG0473	3-isopropylmalate dehydrogenase activity
H7849_00410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7849_00435	COG0577	efflux transmembrane transporter activity
H7849_00435	COG1136	(ABC) transporter
H7849_00445	COG2032	superoxide dismutase activity
H7849_00470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7849_00490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H7849_00500	COG1446	asparaginase
H7849_00535	COG0531	amino acid
H7849_00550	COG0457	Tetratricopeptide repeat
H7849_00605	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H7849_00610	COG0583	DNA-binding transcription factor activity
H7849_00615	COG1538	Outer membrane efflux protein
H7849_00620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7849_00630	COG2197	response regulator
H7849_00635	COG3850	Histidine kinase
H7849_00650	COG1472	Belongs to the glycosyl hydrolase 3 family
H7849_00655	COG1609	Transcriptional regulator
H7849_00705	COG4585	Histidine kinase
H7849_00735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7849_00740	COG0758	DNA mediated transformation
H7849_00755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7849_00765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7849_00775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7849_00785	COG0484	heat shock protein binding
H7849_00790	COG1058	Belongs to the CinA family
H7849_00790	COG1546	Belongs to the CinA family
H7849_00795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7849_00800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7849_00805	COG0552	protein localization to endoplasmic reticulum
H7849_00810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7849_00810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7849_00820	COG1695	Transcriptional regulator
H7849_00830	COG3852	Histidine kinase
H7849_00840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7849_00845	COG0440	acetolactate synthase activity
H7849_00850	COG0028	Belongs to the TPP enzyme family
H7849_00855	COG0129	dihydroxy-acid dehydratase activity
H7849_00860	COG0066	3-isopropylmalate dehydratase activity
H7849_00865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7849_00870	COG0473	3-isopropylmalate dehydrogenase activity
H7849_00875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7849_00880	COG0583	DNA-binding transcription factor activity
H7849_00920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7849_00930	COG1301	dicarboxylic acid transport
H7849_00935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7849_00945	COG2001	Belongs to the MraZ family
H7849_00950	COG0275	rRNA processing
H7849_00960	COG0768	penicillin binding
H7849_00965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7849_00970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7849_00975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7849_00980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7849_00985	COG0772	Belongs to the SEDS family
H7849_00990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7849_01000	COG0577	efflux transmembrane transporter activity
H7849_01000	COG1136	(ABC) transporter
H7849_01015	COG0346	lactoylglutathione lyase activity
H7849_01020	COG0400	carboxylic ester hydrolase activity
H7849_01035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7849_01045	COG1960	acyl-CoA dehydrogenase activity
H7849_01050	COG1703	isobutyryl-CoA mutase activity
H7849_01055	COG0346	lactoylglutathione lyase activity
H7849_01075	COG0688	phosphatidylethanolamine metabolic process
H7849_01080	COG1183	phosphatidylcholine synthase activity
H7849_01105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H7849_01120	COG0138	bifunctional purine biosynthesis protein purh
H7849_01145	COG2020	methyltransferase activity
H7849_01155	COG1476	TRANSCRIPTIONal
H7849_01160	COG1295	ribonuclease BN
H7849_01185	COG3361	conserved protein (COG2071)
H7849_01200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7849_01205	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7849_01210	COG0475	glutathione-regulated potassium exporter activity
H7849_01215	COG0542	response to heat
H7849_01240	COG2770	Histidine kinase
H7849_01240	COG2208	phosphoserine phosphatase activity
H7849_01280	COG3409	Peptidoglycan-binding domain 1 protein
H7849_01280	COG0793	Belongs to the peptidase S41A family
H7849_01285	COG1069	ribulokinase activity
H7849_01310	COG1609	Transcriptional regulator
H7849_01345	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7849_01360	COG1215	transferase activity, transferring glycosyl groups
H7849_01380	COG0489	protein tyrosine kinase activity
H7849_01390	COG3307	-O-antigen
H7849_01395	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7849_01395	COG2755	lipolytic protein G-D-S-L family
H7849_01400	COG0438	transferase activity, transferring glycosyl groups
H7849_01415	COG0442	prolyl-tRNA aminoacylation
H7849_01445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7849_01455	COG1538	Outer membrane efflux protein
H7849_01470	COG3850	Histidine kinase
H7849_01470	COG2205	protein histidine kinase activity
H7849_01470	COG4999	Histidine kinase
H7849_01470	COG3437	response regulator, receiver
H7849_01480	COG3537	Alpha-1,2-mannosidase
H7849_01520	COG0745	RESPONSE REGULATOR receiver
H7849_01525	COG2205	protein histidine kinase activity
H7849_01575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7849_01585	COG1595	DNA-templated transcription, initiation
H7849_01590	COG2259	Doxx family
H7849_01650	COG0823	Involved in the tonB-independent uptake of proteins
H7849_01670	COG1309	transcriptional regulator
H7849_01735	COG1595	DNA-templated transcription, initiation
H7849_01775	COG2814	Major facilitator Superfamily
H7849_01780	COG1566	PFAM secretion protein HlyD family protein
H7849_01800	COG0582	viral genome integration into host DNA
H7849_01805	COG0653	protein targeting
H7849_01870	COG1924	4 iron, 4 sulfur cluster binding
H7849_01875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7849_01880	COG0339	signal peptide processing
H7849_01885	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_01900	COG0037	tRNA processing
H7849_01905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7849_01910	COG0215	cysteine-tRNA ligase activity
H7849_01915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7849_01925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7849_01940	COG2814	Major facilitator Superfamily
H7849_01990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7849_01995	COG0698	ribose 5-phosphate isomerase
H7849_02005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H7849_02010	COG0363	glucosamine-6-phosphate deaminase activity
H7849_02015	COG0837	glucose binding
H7849_02040	COG0312	modulator of DNA gyrase
H7849_02045	COG0312	modulator of DNA gyrase
H7849_02050	COG2318	DinB family
H7849_02060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7849_02065	COG0254	rRNA binding
H7849_02110	COG0582	viral genome integration into host DNA
H7849_02130	COG2197	response regulator
H7849_02135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7849_02140	COG4974	Belongs to the 'phage' integrase family
H7849_02155	COG4191	Histidine kinase
H7849_02165	COG4191	Histidine kinase
H7849_02175	COG0492	ferredoxin-NADP+ reductase activity
H7849_02185	COG4191	Histidine kinase
H7849_02190	COG4566	intracellular signal transduction
H7849_02195	COG4566	intracellular signal transduction
H7849_02235	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7849_02240	COG4974	Belongs to the 'phage' integrase family
H7849_02265	COG4249	Peptidase C14 caspase catalytic subunit p20
H7849_02265	COG2319	Wd-40 repeat
H7849_02280	COG0515	serine threonine protein kinase
H7849_02280	COG2815	serine threonine protein kinase
H7849_02305	COG0776	regulation of translation
H7849_02310	COG1496	oxidoreductase activity
H7849_02325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7849_02335	COG2204	response regulator
H7849_02350	COG2814	Major facilitator Superfamily
H7849_02365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7849_02370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7849_02390	COG2351	hydroxyisourate hydrolase activity
H7849_02410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7849_02425	COG1953	Uracil, thiamine, allantoin
H7849_02440	COG0493	'glutamate synthase
H7849_02455	COG2204	response regulator
H7849_02530	COG0463	Glycosyl transferase, family 2
H7849_02540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7849_02545	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7849_02585	COG1725	Transcriptional regulator
H7849_02600	COG3118	belongs to the thioredoxin family
H7849_02660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7849_02665	COG0577	efflux transmembrane transporter activity
H7849_02665	COG1136	(ABC) transporter
H7849_02680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7849_02700	COG1136	(ABC) transporter
H7849_02700	COG0577	efflux transmembrane transporter activity
H7849_02705	COG0754	glutathionylspermidine amidase activity
H7849_02715	COG0506	proline dehydrogenase activity
H7849_02720	COG0463	Glycosyl transferase, family 2
H7849_02740	COG0673	inositol 2-dehydrogenase activity
H7849_02750	COG4952	isomerase
H7849_02755	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_02755	COG3347	Dehydrogenase
H7849_02760	COG1070	Carbohydrate kinase
H7849_02775	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7849_02795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7849_02800	COG0800	Aldolase
H7849_02805	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_02810	COG1917	Cupin 2, conserved barrel domain protein
H7849_02820	COG1414	Transcriptional regulator
H7849_02835	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H7849_02840	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H7849_02880	COG2205	protein histidine kinase activity
H7849_02885	COG0745	RESPONSE REGULATOR receiver
H7849_02980	COG2885	chlorophyll binding
H7849_02985	COG0823	Involved in the tonB-independent uptake of proteins
H7849_03010	COG0497	DNA recombination
H7849_03030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7849_03035	COG1657	PFAM Prenyltransferase squalene oxidase
H7849_03055	COG1136	(ABC) transporter
H7849_03055	COG0577	efflux transmembrane transporter activity
H7849_03105	COG0612	Peptidase, M16
H7849_03115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7849_03120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7849_03125	COG1063	alcohol dehydrogenase
H7849_03130	COG1063	alcohol dehydrogenase
H7849_03135	COG1562	ergosterol biosynthetic process
H7849_03140	COG1562	ergosterol biosynthetic process
H7849_03145	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H7849_03150	COG3387	PFAM Glycoside hydrolase 15-related
H7849_03195	COG1215	transferase activity, transferring glycosyl groups
H7849_03205	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7849_03230	COG1063	alcohol dehydrogenase
H7849_03235	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_03240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7849_03245	COG2271	Major facilitator Superfamily
H7849_03255	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7849_03260	COG1695	Transcriptional regulator
H7849_03265	COG1136	(ABC) transporter
H7849_03265	COG0577	efflux transmembrane transporter activity
H7849_03270	COG1278	Cold shock
H7849_03275	COG1295	ribonuclease BN
H7849_03280	COG2208	phosphoserine phosphatase activity
H7849_03280	COG2770	Histidine kinase
H7849_03285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7849_03285	COG1648	precorrin-2 dehydrogenase activity
H7849_03295	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H7849_03315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7849_03325	COG0673	inositol 2-dehydrogenase activity
H7849_03355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7849_03375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7849_03380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7849_03405	COG1138	Cytochrome C-type biogenesis protein
H7849_03430	COG0556	nucleotide-excision repair
H7849_03435	COG1501	Belongs to the glycosyl hydrolase 31 family
H7849_03450	COG0534	Mate efflux family protein
H7849_03475	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H7849_03480	COG0457	Tetratricopeptide repeat
H7849_03495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7849_03500	COG2801	Transposase and inactivated derivatives
H7849_03520	COG3409	Peptidoglycan-binding domain 1 protein
H7849_03520	COG3267	Type II secretory pathway component ExeA
H7849_03580	COG0438	transferase activity, transferring glycosyl groups
H7849_03590	COG0492	ferredoxin-NADP+ reductase activity
H7849_03650	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_03655	COG1136	(ABC) transporter
H7849_03655	COG0577	efflux transmembrane transporter activity
H7849_03670	COG0047	phosphoribosylformylglycinamidine synthase activity
H7849_03685	COG0667	Aldo Keto reductase
H7849_03690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7849_03695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7849_03735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7849_03740	COG0009	L-threonylcarbamoyladenylate synthase
H7849_03750	COG1836	PFAM Integral membrane protein DUF92
H7849_03785	COG1704	LemA family
H7849_03795	COG0657	acetylesterase activity
H7849_03795	COG2755	lipolytic protein G-D-S-L family
H7849_03815	COG3706	GGDEF domain
H7849_03850	COG0004	ammonium transporteR
H7849_03855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7849_03885	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H7849_03895	COG1846	Transcriptional regulator
H7849_03910	COG1960	acyl-CoA dehydrogenase activity
H7849_03915	COG3604	Transcriptional regulator
H7849_03920	COG4251	negative regulation of phosphorylation
H7849_03925	COG0784	Response regulator, receiver
H7849_03965	COG2059	Chromate
H7849_03970	COG0673	inositol 2-dehydrogenase activity
H7849_03975	COG2706	6-phosphogluconolactonase activity
H7849_03990	COG0318	PFAM AMP-dependent synthetase and ligase
H7849_04010	COG1278	Cold shock
H7849_04030	COG0175	sulfate reduction
H7849_04055	COG0583	DNA-binding transcription factor activity
H7849_04085	COG2208	phosphoserine phosphatase activity
H7849_04115	COG4948	Mandelate Racemase Muconate Lactonizing
H7849_04130	COG2080	2 iron, 2 sulfur cluster binding
H7849_04135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7849_04150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7849_04155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7849_04165	COG0402	S-adenosylhomocysteine deaminase activity
H7849_04170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7849_04180	COG1131	(ABC) transporter
H7849_04210	COG3781	membrane
H7849_04220	COG1366	Belongs to the anti-sigma-factor antagonist family
H7849_04225	COG1366	Belongs to the anti-sigma-factor antagonist family
H7849_04230	COG2172	sigma factor antagonist activity
H7849_04245	COG4191	Histidine kinase
H7849_04250	COG0784	Response regulator, receiver
H7849_04250	COG2198	Histidine kinase
H7849_04250	COG2205	protein histidine kinase activity
H7849_04255	COG4191	Histidine kinase
H7849_04290	COG0463	Glycosyl transferase, family 2
H7849_04330	COG2132	Multicopper oxidase
H7849_04360	COG0457	Tetratricopeptide repeat
H7849_04365	COG2814	Major facilitator Superfamily
H7849_04365	COG0477	Major facilitator Superfamily
H7849_04380	COG1609	Transcriptional regulator
H7849_04385	COG4948	Mandelate Racemase Muconate Lactonizing
H7849_04425	COG0366	Alpha amylase catalytic
H7849_04435	COG0577	efflux transmembrane transporter activity
H7849_04440	COG4638	Rieske (2fe-2S)
H7849_04445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7849_04455	COG0587	DNA-directed DNA polymerase activity
H7849_04465	COG0720	synthase
H7849_04470	COG0602	queuosine metabolic process
H7849_04480	COG1519	Transferase
H7849_04485	COG1663	tetraacyldisaccharide 4'-kinase activity
H7849_04490	COG0859	PFAM glycosyl transferase family 9
H7849_04510	COG2333	competence protein COMEC
H7849_04510	COG0658	competence protein
H7849_04515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7849_04525	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H7849_04540	COG0525	valine-tRNA ligase activity
H7849_04550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7849_04585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7849_04595	COG2226	methyltransferase
H7849_04605	COG3590	peptidase
H7849_04620	COG3279	Response regulator of the LytR AlgR family
H7849_04650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7849_04660	COG1064	alcohol dehydrogenase
H7849_04675	COG1435	thymidine kinase activity
H7849_04680	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7849_04695	COG3590	peptidase
H7849_04705	COG0736	holo-[acyl-carrier-protein] synthase activity
H7849_04715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7849_04720	COG4152	abc transporter atp-binding protein
H7849_04725	COG1668	transmembrane transport
H7849_04760	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7849_04770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7849_04775	COG1570	exodeoxyribonuclease VII activity
H7849_04790	COG1899	peptidyl-lysine modification to peptidyl-hypusine
H7849_04805	COG0572	uridine kinase
H7849_04815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7849_04825	COG0295	cytidine deaminase activity
H7849_04830	COG0643	Histidine kinase
H7849_04830	COG0784	Response regulator, receiver
H7849_04830	COG2198	Histidine kinase
H7849_04845	COG2201	protein-glutamate methylesterase activity
H7849_04855	COG1201	RNA secondary structure unwinding
H7849_04860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7849_04865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7849_04870	COG2308	Evidence 4 Homologs of previously reported genes of
H7849_04880	COG1305	Transglutaminase-like
H7849_04905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7849_04910	COG0604	alcohol dehydrogenase
H7849_04925	COG0308	aminopeptidase N
H7849_04950	COG0482	sulfurtransferase activity
H7849_04970	COG0513	Belongs to the DEAD box helicase family
H7849_04975	COG1104	cysteine desulfurase activity
H7849_04985	COG0372	Belongs to the citrate synthase family
H7849_04990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7849_04990	COG2022	thiamine diphosphate biosynthetic process
H7849_05010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7849_05010	COG1796	DNA polymerase
H7849_05015	COG1278	Cold shock
H7849_05020	COG0494	nUDIX hydrolase
H7849_05030	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H7849_05050	COG2151	metal-sulfur cluster biosynthetic enzyme
H7849_05090	COG0656	L-ascorbic acid biosynthetic process
H7849_05110	COG2910	NAD(P)H-binding
H7849_05115	COG1024	Enoyl-CoA hydratase
H7849_05170	COG1442	glycosyl transferase family 8
H7849_05170	COG1216	Glycosyl transferase, family 2
H7849_05220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7849_05225	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H7849_05235	COG0315	cyclic pyranopterin monophosphate synthase activity
H7849_05250	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7849_05255	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H7849_05260	COG0456	acetyltransferase
H7849_05275	COG0577	efflux transmembrane transporter activity
H7849_05275	COG1136	(ABC) transporter
H7849_05280	COG1160	GTP binding
H7849_05285	COG1199	ATP-dependent helicase activity
H7849_05290	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7849_05320	COG3064	Membrane
H7849_05350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7849_05370	COG0302	gtp cyclohydrolase
H7849_05375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7849_05385	COG4181	ATPase activity
H7849_05425	COG2140	Oxalate decarboxylase
H7849_05450	COG4191	Histidine kinase
H7849_05455	COG4566	intracellular signal transduction
H7849_05460	COG4566	intracellular signal transduction
H7849_05465	COG3604	Transcriptional regulator
H7849_05485	COG1136	(ABC) transporter
H7849_05485	COG0577	efflux transmembrane transporter activity
H7849_05575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7849_05610	COG0583	DNA-binding transcription factor activity
H7849_05635	COG0583	DNA-binding transcription factor activity
H7849_05665	COG2197	response regulator
H7849_05675	COG4585	Histidine kinase
H7849_05695	COG1566	PFAM secretion protein HlyD family protein
H7849_05705	COG1595	DNA-templated transcription, initiation
H7849_05720	COG1213	nucleotidyl transferase
H7849_05720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7849_05750	COG0738	Major facilitator superfamily
H7849_05780	COG0517	IMP dehydrogenase activity
H7849_05785	COG1007	ATP synthesis coupled electron transport
H7849_05795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7849_05800	COG0713	ATP synthesis coupled electron transport
H7849_05805	COG0839	Belongs to the complex I subunit 6 family
H7849_05810	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7849_05815	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7849_05835	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7849_05835	COG0649	NAD binding
H7849_05840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7849_05845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7849_05860	COG0579	oxidoreductase
H7849_05895	COG3409	Peptidoglycan-binding domain 1 protein
H7849_05895	COG3267	Type II secretory pathway component ExeA
H7849_05900	COG0489	protein tyrosine kinase activity
H7849_05905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7849_05910	COG0673	inositol 2-dehydrogenase activity
H7849_05920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7849_05935	COG1215	transferase activity, transferring glycosyl groups
H7849_05975	COG2244	polysaccharide biosynthetic process
H7849_06020	COG0492	ferredoxin-NADP+ reductase activity
H7849_06030	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H7849_06070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7849_06080	COG2197	response regulator
H7849_06085	COG4585	Histidine kinase
H7849_06095	COG1131	(ABC) transporter
H7849_06100	COG1940	carbohydrate kinase activity
H7849_06140	COG1053	succinate dehydrogenase
H7849_06155	COG0114	fumarate hydratase activity
H7849_06160	COG0281	malic enzyme
H7849_06165	COG0028	Belongs to the TPP enzyme family
H7849_06195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7849_06210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7849_06225	COG1501	Belongs to the glycosyl hydrolase 31 family
H7849_06235	COG4948	Mandelate Racemase Muconate Lactonizing
H7849_06240	COG2271	Major facilitator Superfamily
H7849_06270	COG0646	methionine synthase
H7849_06270	COG1410	methionine synthase
H7849_06305	COG3383	formate dehydrogenase (NAD+) activity
H7849_06315	COG1289	transmembrane transporter activity
H7849_06330	COG1566	PFAM secretion protein HlyD family protein
H7849_06350	COG0596	Alpha beta hydrolase
H7849_06385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7849_06390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7849_06395	COG1538	Outer membrane efflux protein
H7849_06440	COG0154	amidase activity
H7849_06445	COG1131	(ABC) transporter
H7849_06455	COG3250	beta-galactosidase activity
H7849_06465	COG0573	inorganic phosphate transmembrane transporter activity
H7849_06470	COG0581	inorganic phosphate transmembrane transporter activity
H7849_06475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7849_06495	COG1074	ATP-dependent DNA helicase activity
H7849_06510	COG3265	gluconokinase activity
H7849_06520	COG1132	(ABC) transporter
H7849_06540	COG1032	radical SAM domain protein
H7849_06560	COG0477	Major facilitator Superfamily
H7849_06605	COG1970	mechanosensitive ion channel activity
H7849_06610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7849_06620	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7849_06645	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H7849_06655	COG2322	membrane
H7849_06665	COG1131	(ABC) transporter
H7849_06670	COG0109	protoheme IX farnesyltransferase activity
H7849_06675	COG0628	permease
H7849_06680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7849_06695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7849_06705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7849_06735	COG0077	Prephenate dehydratase
H7849_06735	COG1605	Chorismate mutase
H7849_06740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7849_06755	COG0402	S-adenosylhomocysteine deaminase activity
H7849_06765	COG0584	glycerophosphoryl diester phosphodiesterase
H7849_06795	COG0314	molybdopterin synthase activity
H7849_06810	COG0483	inositol monophosphate 1-phosphatase activity
H7849_06830	COG1136	(ABC) transporter
H7849_06830	COG0577	efflux transmembrane transporter activity
H7849_06835	COG1136	(ABC) transporter
H7849_06835	COG0577	efflux transmembrane transporter activity
H7849_06850	COG2226	methyltransferase
H7849_06860	COG1131	(ABC) transporter
H7849_06885	COG1007	ATP synthesis coupled electron transport
H7849_06900	COG0713	ATP synthesis coupled electron transport
H7849_06910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7849_06935	COG0649	NAD binding
H7849_06940	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7849_06945	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7849_06970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7849_06985	COG0583	DNA-binding transcription factor activity
H7849_06990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7849_06995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7849_07010	COG3253	May function as heme-dependent peroxidase
H7849_07020	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_07040	COG1620	l-lactate permease
H7849_07050	COG0673	inositol 2-dehydrogenase activity
H7849_07060	COG0673	inositol 2-dehydrogenase activity
H7849_07070	COG3193	protein, possibly involved in utilization of glycolate and propanediol
H7849_07110	COG1132	(ABC) transporter
H7849_07115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7849_07130	COG0539	negative regulation of cytoplasmic translation
H7849_07155	COG0149	triose-phosphate isomerase activity
H7849_07165	COG0126	phosphoglycerate kinase activity
H7849_07175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7849_07190	COG1174	glycine betaine transport
H7849_07210	COG3275	phosphorelay sensor kinase activity
H7849_07215	COG0438	transferase activity, transferring glycosyl groups
H7849_07220	COG3394	polysaccharide catabolic process
H7849_07260	COG0751	glycine-tRNA ligase activity
H7849_07265	COG0752	glycyl-tRNA synthetase alpha subunit
H7849_07270	COG1381	Involved in DNA repair and RecF pathway recombination
H7849_07310	COG1136	(ABC) transporter
H7849_07310	COG0577	efflux transmembrane transporter activity
H7849_07325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7849_07335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7849_07340	COG0740	serine-type endopeptidase activity
H7849_07345	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7849_07375	COG1573	uracil-dna glycosylase
H7849_07395	COG4251	negative regulation of phosphorylation
H7849_07395	COG3706	GGDEF domain
H7849_07395	COG2203	Gaf domain
H7849_07395	COG5001	Diguanylate cyclase
H7849_07410	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7849_07420	COG0617	tRNA 3'-terminal CCA addition
H7849_07425	COG0590	tRNA wobble adenosine to inosine editing
H7849_07430	COG0577	efflux transmembrane transporter activity
H7849_07430	COG1136	(ABC) transporter
H7849_07435	COG1136	(ABC) transporter
H7849_07435	COG0577	efflux transmembrane transporter activity
H7849_07455	COG0583	DNA-binding transcription factor activity
H7849_07500	COG2222	sugar isomerase
H7849_07505	COG0531	amino acid
H7849_07510	COG1349	DNA-binding transcription factor activity
H7849_07515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7849_07520	COG2226	methyltransferase
H7849_07530	COG2226	methyltransferase
H7849_07540	COG1032	radical SAM domain protein
H7849_07545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7849_07550	COG1032	radical SAM domain protein
H7849_07560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7849_07565	COG1253	flavin adenine dinucleotide binding
H7849_07570	COG0601	transmembrane transport
H7849_07580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7849_07585	COG1573	uracil-dna glycosylase
H7849_07595	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_07615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7849_07620	COG1131	(ABC) transporter
H7849_07630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7849_07660	COG0515	serine threonine protein kinase
H7849_07660	COG2815	serine threonine protein kinase
H7849_07780	COG0542	response to heat
H7849_07785	COG1136	(ABC) transporter
H7849_07805	COG0383	alpha-mannosidase activity
H7849_07810	COG3206	protein involved in exopolysaccharide biosynthesis
H7849_07810	COG0489	protein tyrosine kinase activity
H7849_07815	COG1596	polysaccharide export
H7849_07840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7849_07875	COG0039	L-malate dehydrogenase activity
H7849_07880	COG0538	isocitrate dehydrogenase activity
H7849_07885	COG0673	inositol 2-dehydrogenase activity
H7849_07920	COG0205	6-phosphofructokinase activity
H7849_07935	COG0475	glutathione-regulated potassium exporter activity
H7849_07945	COG0582	viral genome integration into host DNA
H7849_07965	COG2815	serine threonine protein kinase
H7849_07965	COG0515	serine threonine protein kinase
H7849_07985	COG2855	membrane
H7849_07990	COG2072	flavoprotein involved in K transport
H7849_08005	COG2197	response regulator
H7849_08010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7849_08025	COG3345	alpha-galactosidase
H7849_08030	COG1720	tRNA m6t6A37 methyltransferase activity
H7849_08045	COG1324	tolerance protein
H7849_08055	COG1268	BioY protein
H7849_08070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7849_08085	COG0604	alcohol dehydrogenase
H7849_08085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7849_08085	COG3321	synthase
H7849_08085	COG4221	oxidoreductase activity
H7849_08095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7849_08125	COG2080	2 iron, 2 sulfur cluster binding
H7849_08130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7849_08130	COG2010	Cytochrome c
H7849_08145	COG0067	glutamate synthase
H7849_08145	COG0069	glutamate synthase activity
H7849_08145	COG0070	glutamate synthase
H7849_08150	COG1438	arginine binding
H7849_08155	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7849_08160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7849_08165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7849_08170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7849_08175	COG0137	argininosuccinate synthase activity
H7849_08180	COG0165	Argininosuccinate lyase
H7849_08185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7849_08215	COG1136	(ABC) transporter
H7849_08215	COG0577	efflux transmembrane transporter activity
H7849_08220	COG1136	(ABC) transporter
H7849_08220	COG0577	efflux transmembrane transporter activity
H7849_08225	COG0662	Cupin 2, conserved barrel domain protein
H7849_08245	COG0488	(ABC) transporter
H7849_08250	COG0488	(ABC) transporter
H7849_08265	COG3220	belongs to the UPF0276 family
H7849_08315	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7849_08320	COG0356	it plays a direct role in the translocation of protons across the membrane
H7849_08335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7849_08340	COG0024	Methionine aminopeptidase
H7849_08345	COG1692	metallophosphoesterase
H7849_08350	COG1959	2 iron, 2 sulfur cluster binding
H7849_08375	COG4221	oxidoreductase activity
H7849_08380	COG0577	efflux transmembrane transporter activity
H7849_08385	COG1136	(ABC) transporter
H7849_08385	COG0577	efflux transmembrane transporter activity
H7849_08395	COG1196	nuclear chromosome segregation
H7849_08430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7849_08430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7849_08440	COG1127	ABC transporter
H7849_08445	COG0746	molybdenum cofactor guanylyltransferase activity
H7849_08455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7849_08465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7849_08480	COG0825	malonyl-CoA metabolic process
H7849_08500	COG0586	Pfam SNARE associated Golgi protein
H7849_08550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7849_08590	COG1587	Uroporphyrinogen-III synthase
H7849_08595	COG0181	hydroxymethylbilane synthase activity
H7849_08600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7849_08610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7849_08615	COG1472	Belongs to the glycosyl hydrolase 3 family
H7849_08625	COG0436	Aminotransferase
H7849_08630	COG3279	Response regulator of the LytR AlgR family
H7849_08635	COG3275	phosphorelay sensor kinase activity
H7849_08640	COG0598	Magnesium transport protein CorA
H7849_08650	COG1012	belongs to the aldehyde dehydrogenase family
H7849_08690	COG4948	Mandelate Racemase Muconate Lactonizing
H7849_08695	COG2815	serine threonine protein kinase
H7849_08695	COG0515	serine threonine protein kinase
H7849_08710	COG0277	FAD linked oxidase domain protein
H7849_08750	COG3345	alpha-galactosidase
H7849_08765	COG0477	Major facilitator Superfamily
H7849_08765	COG2814	Major facilitator Superfamily
H7849_08775	COG3345	alpha-galactosidase
H7849_08850	COG0646	methionine synthase
H7849_08850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7849_08855	COG1722	exodeoxyribonuclease VII activity
H7849_08860	COG1881	PFAM PEBP family protein
H7849_08865	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7849_08870	COG1560	Kdo2-lipid A biosynthetic process
H7849_08885	COG0717	Belongs to the dCTP deaminase family
H7849_08895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7849_08900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7849_08905	COG2252	PERMEase
H7849_08915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7849_08920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7849_08930	COG1063	alcohol dehydrogenase
H7849_08935	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H7849_08940	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H7849_08945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7849_08950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7849_08960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7849_08990	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H7849_09000	COG0101	tRNA pseudouridine synthase activity
H7849_09025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7849_09030	COG1956	GAF domain-containing protein
H7849_09035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7849_09040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H7849_09045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7849_09065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7849_09095	COG0596	Alpha beta hydrolase
H7849_09105	COG1819	glycosyl
H7849_09155	COG0351	phosphomethylpyrimidine kinase
H7849_09165	COG0284	orotidine-5'-phosphate decarboxylase activity
H7849_09185	COG2204	response regulator
H7849_09190	COG3852	Histidine kinase
H7849_09205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7849_09210	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H7849_09215	COG1595	DNA-templated transcription, initiation
H7849_09225	COG3250	beta-galactosidase activity
H7849_09235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7849_09240	COG1609	Transcriptional regulator
H7849_09245	COG1940	carbohydrate kinase activity
H7849_09250	COG2814	Major facilitator Superfamily
H7849_09250	COG0477	Major facilitator Superfamily
H7849_09265	COG1136	(ABC) transporter
H7849_09265	COG0577	efflux transmembrane transporter activity
H7849_09270	COG1136	(ABC) transporter
H7849_09270	COG0577	efflux transmembrane transporter activity
H7849_09300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7849_09310	COG1053	succinate dehydrogenase
H7849_09335	COG1834	amidinotransferase
H7849_09360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7849_09365	COG1993	acr, cog1993
H7849_09370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7849_09400	COG3275	phosphorelay sensor kinase activity
H7849_09405	COG3279	Response regulator of the LytR AlgR family
H7849_09410	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7849_09450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7849_09465	COG0745	RESPONSE REGULATOR receiver
H7849_09475	COG0778	Nitroreductase
H7849_09495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7849_09505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7849_09515	COG0322	excinuclease ABC activity
H7849_09535	COG0531	amino acid
H7849_09540	COG0297	glycogen (starch) synthase activity
H7849_09545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7849_09560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7849_09565	COG1032	radical SAM domain protein
H7849_09575	COG2022	thiamine diphosphate biosynthetic process
H7849_09585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H7849_09600	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7849_09610	COG0148	phosphopyruvate hydratase activity
H7849_09650	COG0515	serine threonine protein kinase
H7849_09650	COG2815	serine threonine protein kinase
H7849_09680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7849_09705	COG1706	bacterial-type flagellum-dependent cell motility
H7849_09710	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7849_09725	COG4786	Flagellar basal body rod
H7849_09735	COG0745	RESPONSE REGULATOR receiver
H7849_09745	COG1776	CheC inhibitor of MCP methylation
H7849_09745	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7849_09755	COG1191	sigma factor activity
H7849_09760	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7849_09765	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7849_09770	COG1684	flagellar biosynthetic protein fliR
H7849_09795	COG1749	Flagellar hook protein flgE
H7849_09800	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7849_09815	COG1157	protein secretion by the type III secretion system
H7849_09825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7849_09830	COG1766	The M ring may be actively involved in energy transduction
H7849_09835	COG1677	Flagellar hook-basal body complex protein FliE
H7849_09840	COG1558	bacterial-type flagellum-dependent cell motility
H7849_09845	COG1815	bacterial-type flagellum-dependent cell motility
H7849_09860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7849_09865	COG3118	belongs to the thioredoxin family
H7849_09870	COG0083	homoserine kinase activity
H7849_09875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7849_09880	COG5002	protein histidine kinase activity
H7849_09885	COG0745	RESPONSE REGULATOR receiver
H7849_09890	COG0745	RESPONSE REGULATOR receiver
H7849_09895	COG2205	protein histidine kinase activity
H7849_09905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7849_09935	COG0217	transcriptional regulatory protein
H7849_09960	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_09965	COG4948	Mandelate Racemase Muconate Lactonizing
H7849_09975	COG1136	(ABC) transporter
H7849_09975	COG0577	efflux transmembrane transporter activity
H7849_10010	COG0006	proline dipeptidase activity
H7849_10055	COG0583	DNA-binding transcription factor activity
H7849_10070	COG1741	Belongs to the pirin family
H7849_10090	COG0583	DNA-binding transcription factor activity
H7849_10110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7849_10130	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_10135	COG0477	Major facilitator Superfamily
H7849_10140	COG3619	membrane
H7849_10155	COG1294	oxidase, subunit
H7849_10160	COG1271	oxidase subunit
H7849_10185	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H7849_10190	COG1335	isochorismatase
H7849_10210	COG4191	Histidine kinase
H7849_10215	COG4566	intracellular signal transduction
H7849_10220	COG4566	intracellular signal transduction
H7849_10235	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_10240	COG2207	Transcriptional regulator
H7849_10240	COG3708	Transcriptional regulator
H7849_10265	COG1902	pentaerythritol trinitrate reductase activity
H7849_10275	COG0596	Alpha beta hydrolase
H7849_10315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7849_10320	COG3064	Membrane
H7849_10350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7849_10360	COG0583	DNA-binding transcription factor activity
H7849_10365	COG1335	isochorismatase
H7849_10380	COG0583	DNA-binding transcription factor activity
H7849_10405	COG5002	protein histidine kinase activity
H7849_10410	COG0745	RESPONSE REGULATOR receiver
H7849_10475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7849_10495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7849_10505	COG0577	efflux transmembrane transporter activity
H7849_10525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7849_10540	COG1758	RNA polymerase activity
H7849_10545	COG0194	GDP metabolic process
H7849_10550	COG1561	YicC-like family, N-terminal region
H7849_10555	COG1132	(ABC) transporter
H7849_10560	COG1660	Displays ATPase and GTPase activities
H7849_10570	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7849_10575	COG1137	ATPase activity
H7849_10590	COG0577	efflux transmembrane transporter activity
H7849_10590	COG1136	(ABC) transporter
H7849_10595	COG0577	efflux transmembrane transporter activity
H7849_10595	COG1136	(ABC) transporter
H7849_10605	COG2814	Major facilitator Superfamily
H7849_10610	COG1945	arginine decarboxylase activity
H7849_10640	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7849_10645	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7849_10665	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7849_10670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7849_10675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7849_10690	COG0366	Alpha amylase catalytic
H7849_10695	COG0366	Alpha amylase catalytic
H7849_10700	COG0463	Glycosyl transferase, family 2
H7849_10730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7849_10740	COG1132	(ABC) transporter
H7849_10745	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7849_10755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7849_10775	COG1595	DNA-templated transcription, initiation
H7849_10795	COG0531	amino acid
H7849_10800	COG0577	efflux transmembrane transporter activity
H7849_10800	COG1136	(ABC) transporter
H7849_10805	COG0577	efflux transmembrane transporter activity
H7849_10805	COG1136	(ABC) transporter
H7849_10830	COG1408	metallophosphoesterase
H7849_10835	COG1472	Belongs to the glycosyl hydrolase 3 family
H7849_10840	COG1136	(ABC) transporter
H7849_10840	COG0577	efflux transmembrane transporter activity
H7849_10870	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_10880	COG0166	Belongs to the GPI family
H7849_10885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7849_10895	COG1482	cell wall glycoprotein biosynthetic process
H7849_10900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7849_10905	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H7849_10910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7849_10940	COG1960	acyl-CoA dehydrogenase activity
H7849_10955	COG0183	Belongs to the thiolase family
H7849_10965	COG1024	Enoyl-CoA hydratase
H7849_10965	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7849_10980	COG0612	Peptidase, M16
H7849_10985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7849_11000	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7849_11020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7849_11025	COG2124	cytochrome p450
H7849_11030	COG0470	DNA polymerase III
H7849_11040	COG0009	L-threonylcarbamoyladenylate synthase
H7849_11080	COG0653	protein targeting
H7849_11090	COG3537	Alpha-1,2-mannosidase
H7849_11105	COG4974	Belongs to the 'phage' integrase family
H7849_11120	COG0494	nUDIX hydrolase
H7849_11125	COG1136	(ABC) transporter
H7849_11125	COG0577	efflux transmembrane transporter activity
H7849_11145	COG5001	Diguanylate cyclase
H7849_11145	COG3706	GGDEF domain
H7849_11145	COG2203	Gaf domain
H7849_11145	COG4251	negative regulation of phosphorylation
H7849_11190	COG0022	dehydrogenase e1 component
H7849_11195	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H7849_11215	COG0668	transmembrane transport
H7849_11220	COG1331	Highly conserved protein containing a thioredoxin domain
H7849_11225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7849_11235	COG2379	hydroxypyruvate reductase
H7849_11245	COG3852	Histidine kinase
H7849_11250	COG2204	response regulator
H7849_11255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7849_11290	COG1595	DNA-templated transcription, initiation
H7849_11315	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_11350	COG4249	Peptidase C14 caspase catalytic subunit p20
H7849_11350	COG2319	Wd-40 repeat
H7849_11455	COG0667	Aldo Keto reductase
H7849_11470	COG5002	protein histidine kinase activity
H7849_11475	COG0745	RESPONSE REGULATOR receiver
H7849_11480	COG0795	lipopolysaccharide-transporting ATPase activity
H7849_11485	COG1132	(ABC) transporter
H7849_11505	COG3415	Transposase
H7849_11505	COG2801	Transposase and inactivated derivatives
H7849_11510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7849_11520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7849_11530	COG0432	Pfam Uncharacterised protein family UPF0047
H7849_11535	COG2205	protein histidine kinase activity
H7849_11550	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H7849_11555	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H7849_11560	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H7849_11570	COG3483	tryptophan 2,3-dioxygenase activity
H7849_11595	COG0789	Transcriptional regulator
H7849_11645	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_11650	COG0318	PFAM AMP-dependent synthetase and ligase
H7849_11655	COG0076	glutamate decarboxylase activity
H7849_11660	COG2873	o-acetylhomoserine
H7849_11670	COG1012	belongs to the aldehyde dehydrogenase family
H7849_11690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7849_11705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7849_11880	COG0863	Belongs to the N(4) N(6)-methyltransferase family
H7849_11980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7849_11980	COG2755	lipolytic protein G-D-S-L family
H7849_11985	COG0436	Aminotransferase
H7849_11995	COG1695	Transcriptional regulator
H7849_12000	COG0577	efflux transmembrane transporter activity
H7849_12000	COG1136	(ABC) transporter
H7849_12005	COG2818	Glycosylase
H7849_12015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7849_12015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7849_12030	COG4941	Belongs to the sigma-70 factor family
H7849_12035	COG3795	YCII-related domain
H7849_12045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7849_12050	COG0459	protein refolding
H7849_12070	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_12075	COG2855	membrane
H7849_12085	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7849_12090	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7849_12090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7849_12095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7849_12105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7849_12115	COG0505	Belongs to the CarA family
H7849_12130	COG0681	Belongs to the peptidase S26 family
H7849_12155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7849_12180	COG0346	lactoylglutathione lyase activity
H7849_12200	COG2801	Transposase and inactivated derivatives
H7849_12200	COG3415	Transposase
H7849_12215	COG1185	polyribonucleotide nucleotidyltransferase activity
H7849_12220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7849_12250	COG2814	Major facilitator Superfamily
H7849_12255	COG0412	Dienelactone hydrolase
H7849_12265	COG3507	Belongs to the glycosyl hydrolase 43 family
H7849_12265	COG2382	esterase
H7849_12265	COG3693	PFAM glycoside hydrolase, family 10
H7849_12305	COG0629	single-stranded DNA binding
H7849_12315	COG1595	DNA-templated transcription, initiation
H7849_12320	COG3604	Transcriptional regulator
H7849_12335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7849_12365	COG0463	Glycosyl transferase, family 2
H7849_12375	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7849_12375	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7849_12380	COG1609	Transcriptional regulator
H7849_12385	COG2427	Protein of unknown function (DUF1641)
H7849_12390	COG3383	formate dehydrogenase (NAD+) activity
H7849_12395	COG0667	Aldo Keto reductase
H7849_12400	COG0460	homoserine dehydrogenase
H7849_12405	COG3852	Histidine kinase
H7849_12410	COG2204	response regulator
H7849_12420	COG1136	(ABC) transporter
H7849_12420	COG0577	efflux transmembrane transporter activity
H7849_12425	COG1136	(ABC) transporter
H7849_12425	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7849_12435	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_12440	COG1846	Transcriptional regulator
H7849_12455	COG0531	amino acid
H7849_12460	COG0531	amino acid
H7849_12465	COG0352	thiamine-phosphate diphosphorylase activity
H7849_12485	COG0439	Biotin carboxylase
H7849_12490	COG0511	ligase activity, forming carbon-carbon bonds
H7849_12495	COG0006	proline dipeptidase activity
H7849_12500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7849_12505	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7849_12525	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7849_12550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7849_12555	COG0693	protein deglycase activity
H7849_12560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7849_12565	COG0018	arginyl-trna synthetase
H7849_12570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7849_12570	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7849_12575	COG0084	hydrolase, TatD family'
H7849_12580	COG1666	GTP binding
H7849_12585	COG0142	geranyltranstransferase activity
H7849_12590	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7849_12590	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7849_12600	COG0824	Thioesterase
H7849_12605	COG0750	zinc metalloprotease
H7849_12610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7849_12620	COG0575	Belongs to the CDS family
H7849_12630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7849_12630	COG2755	lipolytic protein G-D-S-L family
H7849_12635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7849_12640	COG3064	Membrane
H7849_12685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7849_12695	COG0277	FAD linked oxidase domain protein
H7849_12710	COG1201	RNA secondary structure unwinding
H7849_12735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7849_12740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H7849_12745	COG0154	amidase activity
H7849_12795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7849_12805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7849_12810	COG4521	taurine ABC transporter
H7849_12865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7849_12870	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H7849_12875	COG0495	leucyl-tRNA aminoacylation
H7849_12885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7849_12885	COG0519	Catalyzes the synthesis of GMP from XMP
H7849_12895	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7849_12900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H7849_12915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7849_12935	COG0242	peptide deformylase activity
H7849_12960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7849_12970	COG4941	Belongs to the sigma-70 factor family
H7849_12980	COG0640	Transcriptional regulator
H7849_13005	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_13010	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_13015	COG0640	Transcriptional regulator
H7849_13025	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_13030	COG1902	pentaerythritol trinitrate reductase activity
H7849_13035	COG1309	transcriptional regulator
H7849_13045	COG0583	DNA-binding transcription factor activity
H7849_13060	COG1595	DNA-templated transcription, initiation
H7849_13085	COG1940	carbohydrate kinase activity
H7849_13095	COG1349	DNA-binding transcription factor activity
H7849_13110	COG2272	Belongs to the type-B carboxylesterase lipase family
H7849_13140	COG2271	Major facilitator Superfamily
H7849_13145	COG0673	inositol 2-dehydrogenase activity
H7849_13150	COG0363	glucosamine-6-phosphate deaminase activity
H7849_13170	COG0673	inositol 2-dehydrogenase activity
H7849_13190	COG0477	Major facilitator Superfamily
H7849_13195	COG0363	glucosamine-6-phosphate deaminase activity
H7849_13215	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H7849_13260	COG0298	carbon dioxide binding
H7849_13275	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7849_13285	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H7849_13290	COG0375	protein maturation
H7849_13295	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H7849_13310	COG1063	alcohol dehydrogenase
H7849_13325	COG2140	Oxalate decarboxylase
H7849_13360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7849_13390	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H7849_13420	COG1914	H( )-stimulated, divalent metal cation uptake system
H7849_13425	COG2239	Acts as a magnesium transporter
H7849_13435	COG1366	Belongs to the anti-sigma-factor antagonist family
H7849_13445	COG0789	Transcriptional regulator
H7849_13485	COG2197	response regulator
H7849_13505	COG1136	(ABC) transporter
H7849_13505	COG0577	efflux transmembrane transporter activity
H7849_13510	COG0577	efflux transmembrane transporter activity
H7849_13510	COG1136	(ABC) transporter
H7849_13520	COG0346	lactoylglutathione lyase activity
H7849_13525	COG0741	lytic transglycosylase activity
H7849_13555	COG4232	protein-disulfide reductase activity
H7849_13565	COG1832	CoA-binding protein
H7849_13570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H7849_13575	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7849_13590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7849_13630	COG4948	Mandelate Racemase Muconate Lactonizing
H7849_13640	COG3956	TIGRFAM MazG family protein
H7849_13675	COG0583	DNA-binding transcription factor activity
H7849_13695	COG0501	Belongs to the peptidase M48B family
H7849_13705	COG0012	GTP binding
H7849_13730	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H7849_13740	COG1136	(ABC) transporter
H7849_13740	COG0577	efflux transmembrane transporter activity
H7849_13745	COG1070	Carbohydrate kinase
H7849_13750	COG1609	Transcriptional regulator
H7849_13760	COG3142	Participates in the control of copper homeostasis
H7849_13775	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7849_13785	COG2132	Multicopper oxidase
H7849_13800	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
H7849_13845	COG1612	heme a metabolic process
H7849_13845	COG0109	protoheme IX farnesyltransferase activity
H7849_13860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7849_13865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7849_13875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7849_13905	COG1136	(ABC) transporter
H7849_13910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7849_13930	COG2837	iron assimilation
H7849_13985	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7849_14000	COG0058	SHG alpha-glucan phosphorylase activity
H7849_14015	COG1472	Belongs to the glycosyl hydrolase 3 family
H7849_14020	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7849_14025	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7849_14030	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7849_14050	COG1691	(AIR) carboxylase
H7849_14055	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H7849_14065	COG0667	Aldo Keto reductase
H7849_14085	COG2205	protein histidine kinase activity
H7849_14090	COG2205	protein histidine kinase activity
H7849_14095	COG1002	Type II restriction enzyme, methylase subunits
H7849_14125	COG1085	galactose-1-phosphate uridylyltransferase
H7849_14135	COG2813	Specifically methylates the guanine in position
H7849_14150	COG3240	lipase activity
H7849_14170	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H7849_14180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7849_14185	COG0612	Peptidase, M16
H7849_14195	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7849_14205	COG1472	Belongs to the glycosyl hydrolase 3 family
H7849_14220	COG1136	(ABC) transporter
H7849_14220	COG0577	efflux transmembrane transporter activity
H7849_14245	COG1459	type II secretion system
H7849_14250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7849_14325	COG3186	Phenylalanine-4-hydroxylase
H7849_14330	COG1335	isochorismatase
H7849_14335	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H7849_14345	COG2353	YceI-like domain
H7849_14350	COG1846	Transcriptional regulator
H7849_14370	COG0577	efflux transmembrane transporter activity
H7849_14370	COG1136	(ABC) transporter
H7849_14375	COG3383	formate dehydrogenase (NAD+) activity
H7849_14380	COG2427	Protein of unknown function (DUF1641)
H7849_14385	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7849_14410	COG0702	epimerase
H7849_14420	COG4993	Dehydrogenase
H7849_14435	COG0667	Aldo Keto reductase
H7849_14445	COG0577	efflux transmembrane transporter activity
H7849_14445	COG1136	(ABC) transporter
H7849_14455	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H7849_14480	COG2382	esterase
H7849_14495	COG1566	PFAM secretion protein HlyD family protein
H7849_14505	COG4948	Mandelate Racemase Muconate Lactonizing
H7849_14510	COG1228	amidohydrolase
H7849_14530	COG2188	Transcriptional regulator
H7849_14545	COG4585	Histidine kinase
H7849_14550	COG1136	(ABC) transporter
H7849_14550	COG0577	efflux transmembrane transporter activity
H7849_14560	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H7849_14565	COG1615	UPF0182 protein
H7849_14585	COG0251	oxidation-reduction process
H7849_14590	COG3386	PFAM SMP-30 Gluconolaconase
H7849_14640	COG1030	water channel activity
H7849_14645	COG0330	HflC and HflK could
H7849_14660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7849_14665	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7849_14670	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7849_14675	COG1285	pathogenesis
H7849_14690	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7849_14700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7849_14710	COG0321	lipoyl(octanoyl) transferase activity
H7849_14710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7849_14715	COG0196	riboflavin kinase activity
H7849_14725	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H7849_14735	COG2382	esterase
H7849_14735	COG3693	PFAM glycoside hydrolase, family 10
H7849_14745	COG0512	Glutamine amidotransferase of anthranilate synthase
H7849_14870	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H7849_14910	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_14915	COG1309	transcriptional regulator
H7849_14940	COG1127	ABC transporter
H7849_14950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7849_14960	COG1366	Belongs to the anti-sigma-factor antagonist family
H7849_14995	COG1131	(ABC) transporter
H7849_15020	COG0456	acetyltransferase
H7849_15030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7849_15120	COG3145	DNA-N1-methyladenine dioxygenase activity
H7849_15140	COG1136	(ABC) transporter
H7849_15140	COG0577	efflux transmembrane transporter activity
H7849_15165	COG4191	Histidine kinase
H7849_15175	COG3604	Transcriptional regulator
H7849_15190	COG3604	Transcriptional regulator
H7849_15200	COG1566	PFAM secretion protein HlyD family protein
H7849_15220	COG2814	Major facilitator Superfamily
H7849_15225	COG1566	PFAM secretion protein HlyD family protein
H7849_15245	COG2197	response regulator
H7849_15270	COG4566	intracellular signal transduction
H7849_15300	COG1017	nitric oxide dioxygenase activity
H7849_15300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7849_15325	COG1595	DNA-templated transcription, initiation
H7849_15330	COG0582	viral genome integration into host DNA
H7849_15360	COG2271	Major facilitator Superfamily
H7849_15370	COG2211	Major facilitator Superfamily
H7849_15380	COG1793	dna ligase
H7849_15390	COG4946	Tricorn protease homolog
H7849_15390	COG1506	peptidase
H7849_15390	COG0823	Involved in the tonB-independent uptake of proteins
H7849_15445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7849_15450	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7849_15470	COG1366	Belongs to the anti-sigma-factor antagonist family
H7849_15500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7849_15505	COG0823	Involved in the tonB-independent uptake of proteins
H7849_15505	COG1506	peptidase
H7849_15505	COG4946	Tricorn protease homolog
H7849_15515	COG1505	serine-type exopeptidase activity
H7849_15530	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H7849_15590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7849_15595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7849_15605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7849_15610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7849_15660	COG1940	carbohydrate kinase activity
H7849_15670	COG2814	Major facilitator Superfamily
H7849_15675	COG1940	carbohydrate kinase activity
H7849_15705	COG0251	oxidation-reduction process
H7849_15710	COG1921	L-seryl-tRNASec selenium transferase activity
H7849_15715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7849_15720	COG2197	response regulator
H7849_15725	COG4585	Histidine kinase
H7849_15730	COG2271	Major facilitator Superfamily
H7849_15740	COG4181	ATPase activity
H7849_15750	COG3964	amidohydrolase
H7849_15760	COG0535	radical SAM domain protein
H7849_15775	COG2197	response regulator
H7849_15800	COG4974	Belongs to the 'phage' integrase family
H7849_15815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7849_15840	COG1960	acyl-CoA dehydrogenase activity
H7849_15850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7849_15895	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_15905	COG1309	transcriptional regulator
H7849_15910	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_15915	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_15925	COG1902	pentaerythritol trinitrate reductase activity
H7849_15935	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_16015	COG3474	cytochrome
H7849_16020	COG1595	DNA-templated transcription, initiation
H7849_16030	COG1136	(ABC) transporter
H7849_16030	COG0577	efflux transmembrane transporter activity
H7849_16050	COG0110	maltose O-acetyltransferase activity
H7849_16055	COG0110	maltose O-acetyltransferase activity
H7849_16125	COG2376	Dihydroxyacetone kinase
H7849_16130	COG2897	thiosulfate sulfurtransferase activity
H7849_16160	COG3537	Alpha-1,2-mannosidase
H7849_16170	COG1921	L-seryl-tRNASec selenium transferase activity
H7849_16175	COG0745	RESPONSE REGULATOR receiver
H7849_16185	COG0366	Alpha amylase catalytic
H7849_16200	COG1940	carbohydrate kinase activity
H7849_16275	COG3338	carbonate dehydratase activity
H7849_16290	COG0268	Binds directly to 16S ribosomal RNA
H7849_16300	COG3609	addiction module antidote protein, CC2985 family
H7849_16305	COG0489	protein tyrosine kinase activity
H7849_16310	COG1607	acyl-coa hydrolase
H7849_16320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7849_16335	COG1819	glycosyl
H7849_16350	COG1254	Belongs to the acylphosphatase family
H7849_16355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7849_16365	COG3685	Protein conserved in bacteria
H7849_16380	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7849_16420	COG0577	efflux transmembrane transporter activity
H7849_16440	COG1595	DNA-templated transcription, initiation
H7849_16490	COG3064	Membrane
H7849_16495	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7849_16500	COG3189	MarR family transcriptional regulator
H7849_16565	COG4783	chaperone-mediated protein folding
H7849_16575	COG2095	MarC family integral membrane protein
H7849_16590	COG1136	(ABC) transporter
H7849_16590	COG0577	efflux transmembrane transporter activity
H7849_16610	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7849_16645	COG0745	RESPONSE REGULATOR receiver
H7849_16650	COG3852	Histidine kinase
H7849_16705	COG4774	siderophore transport
H7849_16730	COG1596	polysaccharide export
H7849_16735	COG3206	protein involved in exopolysaccharide biosynthesis
H7849_16735	COG0489	protein tyrosine kinase activity
H7849_16745	COG0673	inositol 2-dehydrogenase activity
H7849_16845	COG0456	acetyltransferase
H7849_16850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7849_16855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7849_16860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7849_16865	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H7849_16905	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7849_16925	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H7849_16935	COG0644	oxidoreductase
H7849_16945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7849_16955	COG0504	CTP synthase activity
H7849_16965	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_16970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7849_16995	COG1136	(ABC) transporter
H7849_16995	COG0577	efflux transmembrane transporter activity
H7849_17010	COG0673	inositol 2-dehydrogenase activity
H7849_17020	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_17025	COG4948	Mandelate Racemase Muconate Lactonizing
H7849_17030	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7849_17040	COG1556	Lactate utilization protein
H7849_17045	COG1139	Iron-sulfur cluster binding protein
H7849_17050	COG0247	lactate metabolic process
H7849_17055	COG1472	Belongs to the glycosyl hydrolase 3 family
H7849_17070	COG0175	sulfate reduction
H7849_17075	COG2895	sulfate adenylyltransferase (ATP) activity
H7849_17080	COG0175	sulfate reduction
H7849_17115	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
H7849_17175	COG4974	Belongs to the 'phage' integrase family
H7849_17250	COG4974	Belongs to the 'phage' integrase family
H7849_17255	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7849_17290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7849_17305	COG2226	methyltransferase
H7849_17315	COG0798	PFAM Bile acid sodium symporter
H7849_17320	COG3511	phospholipase C
H7849_17330	COG0701	Predicted permease
H7849_17335	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7849_17390	COG4977	sequence-specific DNA binding
H7849_17410	COG1914	H( )-stimulated, divalent metal cation uptake system
H7849_17430	COG0708	Exodeoxyribonuclease III
H7849_17465	COG3537	Alpha-1,2-mannosidase
H7849_17475	COG3064	Membrane
H7849_17510	COG1063	alcohol dehydrogenase
H7849_17520	COG2197	response regulator
H7849_17525	COG5001	Diguanylate cyclase
H7849_17570	COG1595	DNA-templated transcription, initiation
H7849_17575	COG2183	response to ionizing radiation
H7849_17590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7849_17590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7849_17615	COG5492	domain, Protein
H7849_17615	COG4932	domain protein
H7849_17625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7849_17630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7849_17670	COG1595	DNA-templated transcription, initiation
H7849_17680	COG5434	Belongs to the glycosyl hydrolase 28 family
H7849_17685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7849_17690	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7849_17695	COG0195	Participates in both transcription termination and antitermination
H7849_17700	COG0779	Required for maturation of 30S ribosomal subunits
H7849_17705	COG0235	Class ii aldolase
H7849_17725	COG0516	GMP reductase activity
H7849_17725	COG0517	IMP dehydrogenase activity
H7849_17740	COG0203	ribosomal protein L17
H7849_17745	COG0202	RNA polymerase activity
H7849_17750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7849_17755	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7849_17760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7849_17765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7849_17770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7849_17780	COG0563	adenylate kinase activity
H7849_17790	COG0200	Binds to the 23S rRNA
H7849_17795	COG1841	ribosomal large subunit assembly
H7849_17800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7849_17805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7849_17810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7849_17815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7849_17825	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7849_17830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7849_17835	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7849_17840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7849_17845	COG0255	Belongs to the universal ribosomal protein uL29 family
H7849_17850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7849_17855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7849_17860	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7849_17865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7849_17870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7849_17875	COG0089	rRNA binding
H7849_17880	COG0088	Forms part of the polypeptide exit tunnel
H7849_17885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7849_17890	COG0051	transcription antitermination factor activity, RNA binding
H7849_17900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7849_17905	COG0049	tRNA binding
H7849_17910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7849_17915	COG1506	peptidase
H7849_17915	COG4946	Tricorn protease homolog
H7849_17915	COG0823	Involved in the tonB-independent uptake of proteins
H7849_17950	COG0792	nuclease activity
H7849_17960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7849_17965	COG0596	Alpha beta hydrolase
H7849_17970	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7849_17975	COG0456	acetyltransferase
H7849_17975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7849_17980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7849_18040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7849_18065	COG0745	RESPONSE REGULATOR receiver
H7849_18075	COG0789	Transcriptional regulator
H7849_18080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7849_18100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7849_18105	COG1362	aminopeptidase activity
H7849_18110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7849_18115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7849_18145	COG0154	amidase activity
H7849_18150	COG4608	Belongs to the ABC transporter superfamily
H7849_18180	COG0210	DNA helicase
H7849_18190	COG0531	amino acid
H7849_18195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7849_18205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H7849_18210	COG3858	chitin binding
H7849_18220	COG1914	H( )-stimulated, divalent metal cation uptake system
H7849_18225	COG0151	Belongs to the GarS family
H7849_18240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7849_18245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7849_18255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7849_18265	COG2255	four-way junction helicase activity
H7849_18295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7849_18305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7849_18310	COG1643	Atp-dependent helicase
H7849_18325	COG1024	Enoyl-CoA hydratase
H7849_18335	COG3344	reverse transcriptase
H7849_18350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7849_18355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7849_18365	COG2814	Major facilitator Superfamily
H7849_18370	COG1960	acyl-CoA dehydrogenase activity
H7849_18380	COG0247	lactate metabolic process
H7849_18380	COG0277	FAD linked oxidase domain protein
H7849_18395	COG0436	Aminotransferase
H7849_18405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7849_18410	COG0107	imidazoleglycerol-phosphate synthase activity
H7849_18415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7849_18420	COG0131	Imidazoleglycerol-phosphate dehydratase
H7849_18425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7849_18430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7849_18435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7849_18440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7849_18445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7849_18480	COG1295	ribonuclease BN
H7849_18485	COG0469	pyruvate kinase activity
H7849_18490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7849_18500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7849_18525	COG1595	DNA-templated transcription, initiation
H7849_18540	COG2208	phosphoserine phosphatase activity
H7849_18540	COG2770	Histidine kinase
H7849_18550	COG0076	glutamate decarboxylase activity
H7849_18575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7849_18585	COG2094	Belongs to the DNA glycosylase MPG family
H7849_18595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7849_18600	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7849_18605	COG1285	pathogenesis
H7849_18610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7849_18620	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7849_18625	COG3619	membrane
H7849_18635	COG0017	Asparaginyl-tRNA synthetase
H7849_18655	COG0405	Gamma-glutamyltransferase
H7849_18660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7849_18670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7849_18675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7849_18680	COG0193	aminoacyl-tRNA hydrolase activity
H7849_18685	COG0360	Binds together with S18 to 16S ribosomal RNA
H7849_18690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7849_18695	COG0359	binds to the 23S rRNA
H7849_18710	COG0189	ligase activity
H7849_18715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7849_18745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7849_18745	COG0515	serine threonine protein kinase
H7849_18765	COG0668	transmembrane transport
H7849_18800	COG2197	response regulator
H7849_18805	COG2197	response regulator
H7849_18810	COG2197	response regulator
H7849_18815	COG5001	Diguanylate cyclase
H7849_18830	COG0252	asparaginase activity
H7849_18840	COG3064	Membrane
H7849_18850	COG2885	chlorophyll binding
H7849_18880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7849_18915	COG1538	Outer membrane efflux protein
H7849_18960	COG3710	Transcriptional regulator
H7849_18965	COG0577	efflux transmembrane transporter activity
H7849_18965	COG1136	(ABC) transporter
H7849_18980	COG0450	alkyl hydroperoxide reductase
H7849_19005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7849_19030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7849_19035	COG0515	serine threonine protein kinase
H7849_19055	COG1733	regulation of RNA biosynthetic process
H7849_19065	COG1228	amidohydrolase
H7849_19085	COG3619	membrane
H7849_19095	COG2197	response regulator
H7849_19100	COG4585	Histidine kinase
H7849_19105	COG1321	iron dependent repressor
H7849_19125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7849_19130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7849_19150	COG2040	homocysteine
H7849_19155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7849_19160	COG0237	dephospho-CoA kinase activity
H7849_19165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7849_19180	COG2835	tetraacyldisaccharide 4'-kinase activity
H7849_19185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7849_19185	COG0546	phosphoglycolate phosphatase activity
H7849_19190	COG0277	FAD linked oxidase domain protein
H7849_19195	COG0300	oxidoreductase activity
H7849_19215	COG0537	adenosine 5'-monophosphoramidase activity
H7849_19230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7849_19235	COG1874	Beta-galactosidase
H7849_19250	COG2801	Transposase and inactivated derivatives
H7849_19250	COG3415	Transposase
H7849_19305	COG0156	8-amino-7-oxononanoate synthase activity
H7849_19315	COG0577	efflux transmembrane transporter activity
H7849_19315	COG1136	(ABC) transporter
H7849_19330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7849_19370	COG0358	DNA primase activity
H7849_19380	COG2314	TM2 domain
H7849_19390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7849_19400	COG0739	heme binding
H7849_19405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7849_19410	COG2706	6-phosphogluconolactonase activity
H7849_19415	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H7849_19430	COG0424	maF-like protein
H7849_19445	COG3676	manually curated
H7849_19470	COG2132	Multicopper oxidase
H7849_19475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7849_19480	COG0577	efflux transmembrane transporter activity
H7849_19480	COG1136	(ABC) transporter
H7849_19495	COG0745	RESPONSE REGULATOR receiver
H7849_19515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7849_19540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7849_19545	COG1937	Protein conserved in bacteria
H7849_19550	COG2217	Heavy metal translocating P-type atpase
H7849_19560	COG0577	efflux transmembrane transporter activity
H7849_19560	COG1136	(ABC) transporter
H7849_19565	COG1695	Transcriptional regulator
H7849_19575	COG2860	membrane
H7849_19585	COG0233	cytoplasmic translational termination
H7849_19610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7849_19615	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7849_19670	COG3041	Addiction module toxin RelE StbE family
H7849_19680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7849_19700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7849_19705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7849_19715	COG1136	(ABC) transporter
H7849_19715	COG0577	efflux transmembrane transporter activity
H7849_19720	COG0596	Alpha beta hydrolase
H7849_19730	COG0406	alpha-ribazole phosphatase activity
H7849_19750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7849_19765	COG3415	Transposase
H7849_19765	COG2801	Transposase and inactivated derivatives
H7849_19785	COG2801	Transposase and inactivated derivatives
H7849_19785	COG3415	Transposase
H7849_19795	COG2345	Transcriptional regulator
H7849_19815	COG2208	phosphoserine phosphatase activity
H7849_19835	COG0297	glycogen (starch) synthase activity
H7849_19840	COG0386	Belongs to the glutathione peroxidase family
H7849_19850	COG0481	GTPase activity
H7849_19855	COG1388	LysM domain
H7849_19855	COG0741	lytic transglycosylase activity
H7849_19885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7849_19900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7849_19915	COG1595	DNA-templated transcription, initiation
H7849_19925	COG2801	Transposase and inactivated derivatives
H7849_19925	COG3415	Transposase
H7849_19955	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_19970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7849_19980	COG0501	Belongs to the peptidase M48B family
H7849_19985	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7849_20040	COG3291	Pkd domain containing protein
H7849_20060	COG1446	asparaginase
H7849_20090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7849_20090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7849_20100	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_20105	COG2271	Major facilitator Superfamily
H7849_20115	COG1082	Xylose isomerase domain protein TIM barrel
H7849_20125	COG0589	response to stress
H7849_20145	COG0564	pseudouridine synthase activity
H7849_20160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7849_20180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7849_20180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7849_20205	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7849_20215	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7849_20230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7849_20235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7849_20235	COG0072	phenylalanine-tRNA ligase activity
H7849_20245	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H7849_20255	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7849_20270	COG2721	sulfolactate sulfo-lyase activity
H7849_20275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7849_20300	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H7849_20310	COG0071	Belongs to the small heat shock protein (HSP20) family
H7849_20315	COG0542	response to heat
H7849_20325	COG4993	Dehydrogenase
H7849_20340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7849_20360	COG0457	Tetratricopeptide repeat
H7849_20360	COG3710	Transcriptional regulator
H7849_20365	COG0823	Involved in the tonB-independent uptake of proteins
H7849_20365	COG4946	Tricorn protease homolog
H7849_20365	COG1506	peptidase
H7849_20405	COG1366	Belongs to the anti-sigma-factor antagonist family
H7849_20475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7849_20520	COG0714	Associated with various cellular activities
H7849_20545	COG2132	Multicopper oxidase
H7849_20550	COG0577	efflux transmembrane transporter activity
H7849_20565	COG1217	gtp-binding protein TYPA
H7849_20575	COG1611	Belongs to the LOG family
H7849_20585	COG0154	amidase activity
H7849_20590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7849_20625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7849_20665	COG0437	4 iron, 4 sulfur cluster binding
H7849_20680	COG2234	aminopeptidase activity
H7849_20695	COG1136	(ABC) transporter
H7849_20695	COG0577	efflux transmembrane transporter activity
H7849_20700	COG0416	fatty acid biosynthetic process
H7849_20705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7849_20750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7849_20760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7849_20760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7849_20765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7849_20770	COG0673	inositol 2-dehydrogenase activity
H7849_20785	COG0511	ligase activity, forming carbon-carbon bonds
H7849_20790	COG0439	Biotin carboxylase
H7849_20805	COG0848	biopolymer transport protein
H7849_20820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7849_20825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7849_20830	COG1862	Preprotein translocase
H7849_20850	COG0823	Involved in the tonB-independent uptake of proteins
H7849_20850	COG1506	peptidase
H7849_20890	COG0640	Transcriptional regulator
H7849_20900	COG0604	alcohol dehydrogenase
H7849_20900	COG3321	synthase
H7849_20915	COG2084	Dehydrogenase
H7849_20925	COG0025	NhaP-type Na H and K H
H7849_20930	COG1136	(ABC) transporter
H7849_20930	COG0577	efflux transmembrane transporter activity
H7849_20935	COG0343	queuine tRNA-ribosyltransferase activity
H7849_20950	COG1012	belongs to the aldehyde dehydrogenase family
H7849_20965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7849_20970	COG0799	negative regulation of ribosome biogenesis
H7849_20980	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7849_20985	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H7849_20990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7849_21030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7849_21035	COG0357	Ribosomal RNA small subunit methyltransferase G
H7849_21040	COG1192	Involved in chromosome partitioning
H7849_21045	COG1475	DNA binding
H7849_21050	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H7849_21060	COG2208	phosphoserine phosphatase activity
H7849_21085	COG0577	efflux transmembrane transporter activity
H7849_21085	COG1136	(ABC) transporter
H7849_21090	COG1136	(ABC) transporter
H7849_21090	COG0577	efflux transmembrane transporter activity
H7849_21100	COG1228	amidohydrolase
H7849_21115	COG0776	regulation of translation
H7849_21125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7849_21135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7849_21145	COG4941	Belongs to the sigma-70 factor family
H7849_21155	COG2764	glyoxalase bleomycin resistance protein dioxygenase
H7849_21180	COG0632	four-way junction helicase activity
H7849_21205	COG2814	Major facilitator Superfamily
H7849_21235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7849_21250	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7849_21250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7849_21255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7849_21280	COG0463	Glycosyl transferase, family 2
H7849_21295	COG0110	maltose O-acetyltransferase activity
H7849_21310	COG0859	PFAM glycosyl transferase family 9
H7849_21375	COG0582	viral genome integration into host DNA
H7849_21380	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7849_21390	COG0706	membrane insertase activity
H7849_21395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7849_21400	COG0594	ribonuclease P activity
H7849_21405	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7849_21425	COG0592	DNA-directed DNA polymerase activity
H7849_21445	COG1193	negative regulation of DNA recombination
H7849_21455	COG0113	porphobilinogen synthase activity
H7849_21460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7849_21465	COG0321	lipoyl(octanoyl) transferase activity
H7849_21470	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7849_21475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7849_21585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7849_21590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7849_21595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7849_21615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7849_21625	COG1278	Cold shock
H7849_21630	COG1819	glycosyl
H7849_21650	COG2910	NAD(P)H-binding
H7849_21655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7849_21665	COG2353	YceI-like domain
H7849_21670	COG0656	L-ascorbic acid biosynthetic process
H7849_21695	COG1012	belongs to the aldehyde dehydrogenase family
H7849_21710	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_21725	COG1733	regulation of RNA biosynthetic process
H7849_21750	COG2197	response regulator
H7849_21755	COG1653	transport
H7849_21800	COG0604	alcohol dehydrogenase
H7849_21805	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7849_21825	COG1252	NADH dehydrogenase
H7849_21850	COG2353	YceI-like domain
H7849_21875	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7849_21880	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_21890	COG1764	response to oxidative stress
H7849_21930	COG1595	DNA-templated transcription, initiation
H7849_21945	COG1012	belongs to the aldehyde dehydrogenase family
H7849_21995	COG0583	DNA-binding transcription factor activity
H7849_22005	COG4191	Histidine kinase
H7849_22010	COG0583	DNA-binding transcription factor activity
H7849_22045	COG0583	DNA-binding transcription factor activity
H7849_22100	COG4191	Histidine kinase
H7849_22125	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7849_22140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7849_22185	COG4106	trans-aconitate 2-methyltransferase activity
H7849_22200	COG2197	response regulator
H7849_22255	COG2815	serine threonine protein kinase
H7849_22255	COG0515	serine threonine protein kinase
H7849_22260	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H7849_22275	COG0076	glutamate decarboxylase activity
H7849_22285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7849_22290	COG0058	SHG alpha-glucan phosphorylase activity
H7849_22340	COG1131	(ABC) transporter
H7849_22350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7849_22355	COG0445	tRNA wobble uridine modification
H7849_22380	COG2423	ornithine cyclodeaminase activity
H7849_22395	COG0577	efflux transmembrane transporter activity
H7849_22395	COG1136	(ABC) transporter
H7849_22400	COG0577	efflux transmembrane transporter activity
H7849_22400	COG1136	(ABC) transporter
H7849_22405	COG0577	efflux transmembrane transporter activity
H7849_22405	COG1136	(ABC) transporter
H7849_22410	COG1136	(ABC) transporter
H7849_22410	COG0577	efflux transmembrane transporter activity
H7849_22420	COG2081	HI0933 family
H7849_22430	COG4956	integral membrane protein (PIN domain superfamily)
H7849_22455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7849_22470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7849_22480	COG0742	ribosomal rna small subunit methyltransferase
H7849_22495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7849_22505	COG0739	heme binding
H7849_22525	COG2815	serine threonine protein kinase
H7849_22525	COG0515	serine threonine protein kinase
H7849_22580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7849_22585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7849_22605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7849_22610	COG0081	regulation of translation
H7849_22615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7849_22620	COG0222	ribosome binding
H7849_22625	COG0085	RNA polymerase activity
H7849_22630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7849_22645	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7849_22655	COG0243	molybdopterin cofactor binding
H7849_22660	COG2169	Transcriptional regulator
H7849_22660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7849_22670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7849_22675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7849_22695	COG1793	dna ligase
H7849_22700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7849_22705	COG2890	protein-(glutamine-N5) methyltransferase activity
H7849_22710	COG2309	aminopeptidase activity
H7849_22715	COG0535	radical SAM domain protein
H7849_22720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7849_22745	COG3511	phospholipase C
H7849_22750	COG0386	Belongs to the glutathione peroxidase family
H7849_22755	COG0667	Aldo Keto reductase
H7849_22760	COG1610	YqeY-like protein
H7849_22765	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7849_22770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7849_22780	COG0305	Participates in initiation and elongation during chromosome replication
H7849_22820	COG1322	Protein conserved in bacteria
H7849_22825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7849_22830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7849_22835	COG1278	Cold shock
H7849_22850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7849_22895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7849_22900	COG0488	(ABC) transporter
H7849_22925	COG0366	Alpha amylase catalytic
H7849_22935	COG0842	Transport permease protein
H7849_22970	COG1063	alcohol dehydrogenase
H7849_22980	COG0656	L-ascorbic acid biosynthetic process
H7849_23015	COG1505	serine-type exopeptidase activity
H7849_23020	COG3622	Belongs to the hyi family
H7849_23035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7849_23045	COG1959	2 iron, 2 sulfur cluster binding
H7849_23050	COG1104	cysteine desulfurase activity
H7849_23060	COG0316	Belongs to the HesB IscA family
H7849_23070	COG0443	Heat shock 70 kDa protein
H7849_23075	COG0633	Ferredoxin
H7849_23080	COG2975	iron-sulfur cluster assembly
H7849_23110	COG4948	Mandelate Racemase Muconate Lactonizing
H7849_23150	COG3710	Transcriptional regulator
H7849_23165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7849_23170	COG2326	polyphosphate kinase activity
H7849_23175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7849_23180	COG0540	Belongs to the ATCase OTCase family
H7849_23185	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H7849_23205	COG1902	pentaerythritol trinitrate reductase activity
H7849_23275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7849_23280	COG0124	histidyl-tRNA synthetase
H7849_23300	COG1131	(ABC) transporter
H7849_23310	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7849_23320	COG0745	RESPONSE REGULATOR receiver
H7849_23325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7849_23365	COG4106	trans-aconitate 2-methyltransferase activity
H7849_23385	COG1012	belongs to the aldehyde dehydrogenase family
H7849_23450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7849_23470	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_23485	COG0028	Belongs to the TPP enzyme family
H7849_23500	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H7849_23525	COG1228	amidohydrolase
H7849_23530	COG0531	amino acid
H7849_23540	COG1196	nuclear chromosome segregation
H7849_23545	COG2208	phosphoserine phosphatase activity
H7849_23575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7849_23620	COG0577	efflux transmembrane transporter activity
H7849_23620	COG1136	(ABC) transporter
H7849_23640	COG0366	Alpha amylase catalytic
H7849_23670	COG2855	membrane
H7849_23675	COG0583	DNA-binding transcription factor activity
H7849_23685	COG0557	exoribonuclease II activity
H7849_23695	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H7849_23700	COG0251	oxidation-reduction process
H7849_23720	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H7849_23730	COG0159	tryptophan synthase activity
H7849_23735	COG0133	tryptophan synthase activity
H7849_23740	COG0135	phosphoribosylanthranilate isomerase activity
H7849_23745	COG0134	indole-3-glycerol-phosphate synthase activity
H7849_23815	COG1506	peptidase
H7849_23815	COG4946	Tricorn protease homolog
H7849_23815	COG0823	Involved in the tonB-independent uptake of proteins
H7849_23845	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7849_23860	COG1764	response to oxidative stress
H7849_23870	COG1695	Transcriptional regulator
H7849_23925	COG0039	L-malate dehydrogenase activity
H7849_23935	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7849_23950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7849_23975	COG1506	peptidase
H7849_23975	COG0823	Involved in the tonB-independent uptake of proteins
H7849_23980	COG3852	Histidine kinase
H7849_23995	COG1040	competence protein
H7849_24005	COG0697	spore germination
H7849_24020	COG1297	OPT oligopeptide transporter protein
H7849_24020	COG1297	OPT oligopeptide transporter protein
H7849_24030	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H7849_24065	COG1845	cytochrome c oxidase, subunit III
H7849_24075	COG2010	Cytochrome c
H7849_24075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7849_24085	COG2188	Transcriptional regulator
H7849_24100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7849_24105	COG2080	2 iron, 2 sulfur cluster binding
H7849_24110	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7849_24115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7849_24120	COG3608	succinylglutamate desuccinylase aspartoacylase
H7849_24120	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H7849_24125	COG0746	molybdenum cofactor guanylyltransferase activity
H7849_24135	COG0105	UTP biosynthetic process
H7849_24165	COG2223	nitrite transmembrane transporter activity
H7849_24170	COG0243	molybdopterin cofactor binding
H7849_24175	COG0437	4 iron, 4 sulfur cluster binding
H7849_24180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7849_24190	COG1587	Uroporphyrinogen-III synthase
H7849_24245	COG0583	DNA-binding transcription factor activity
H7849_24255	COG0745	RESPONSE REGULATOR receiver
H7849_24260	COG4191	Histidine kinase
H7849_24265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7849_24270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7849_24275	COG1428	Deoxynucleoside kinase
H7849_24280	COG0726	polysaccharide deacetylase
H7849_24285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7849_24305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7849_24310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7849_24345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7849_24360	COG3093	addiction module antidote protein HigA
H7849_24400	COG1501	Belongs to the glycosyl hydrolase 31 family
H7849_24405	COG1187	pseudouridine synthase activity
H7849_24410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7849_24415	COG0306	phosphate transporter
H7849_24420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H7849_24425	COG0180	Tryptophanyl-tRNA synthetase
H7849_24450	COG1994	Peptidase M50
H7849_24465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7849_24480	COG0045	succinate-CoA ligase (ADP-forming) activity
H7849_24485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H7849_24490	COG0793	Belongs to the peptidase S41A family
H7849_24500	COG3481	metal-dependent phosphohydrolase, HD sub domain
H7849_24510	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7849_24515	COG0242	peptide deformylase activity
H7849_24520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7849_24525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7849_24525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7849_24540	COG2226	methyltransferase
H7849_24545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7849_24550	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7849_24565	COG0805	protein transport
H7849_24570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7849_24580	COG2801	Transposase and inactivated derivatives
H7849_24580	COG3415	Transposase
H7849_24625	COG2801	Transposase and inactivated derivatives
H7849_24625	COG3415	Transposase
H7849_24630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7849_24640	COG0735	belongs to the Fur family
H7849_24650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7849_24655	COG2885	chlorophyll binding
H7849_24660	COG2234	aminopeptidase activity
H7849_24670	COG2208	phosphoserine phosphatase activity
H7849_24675	COG0628	permease
H7849_24685	COG1923	regulation of RNA biosynthetic process
H7849_24690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7849_24700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7849_24705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7849_24710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7849_24715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7849_24720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7849_24725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7849_24730	COG0631	protein serine/threonine phosphatase activity
H7849_24735	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7849_24755	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7849_24770	COG0110	maltose O-acetyltransferase activity
H7849_24775	COG0167	dihydroorotate dehydrogenase activity
H7849_24780	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
H7849_24785	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7849_24790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7849_24815	COG4122	O-methyltransferase activity
H7849_24820	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_24825	COG1012	belongs to the aldehyde dehydrogenase family
H7849_24830	COG2197	response regulator
H7849_24855	COG0667	Aldo Keto reductase
H7849_24865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7849_24870	COG0509	glycine decarboxylation via glycine cleavage system
H7849_24875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7849_24880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7849_24905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7849_24925	COG0745	RESPONSE REGULATOR receiver
H7849_24940	COG0681	Belongs to the peptidase S26 family
H7849_24980	COG2197	response regulator
H7849_24985	COG0577	efflux transmembrane transporter activity
H7849_24985	COG1136	(ABC) transporter
H7849_25005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7849_25010	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7849_25015	COG0052	Belongs to the universal ribosomal protein uS2 family
H7849_25020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7849_25030	COG1501	Belongs to the glycosyl hydrolase 31 family
H7849_25045	COG0528	UMP kinase activity
H7849_25060	COG3706	GGDEF domain
H7849_25065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7849_25070	COG0626	cystathionine gamma-synthase activity
H7849_25085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7849_25095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H7849_25105	COG0248	Ppx GppA phosphatase
H7849_25110	COG2062	phosphohistidine phosphatase, SixA
H7849_25145	COG2124	cytochrome p450
H7849_25150	COG0783	Belongs to the Dps family
H7849_25160	COG1136	(ABC) transporter
H7849_25160	COG0577	efflux transmembrane transporter activity
H7849_25190	COG0438	transferase activity, transferring glycosyl groups
H7849_25195	COG0438	transferase activity, transferring glycosyl groups
H7849_25205	COG0438	transferase activity, transferring glycosyl groups
H7849_25245	COG0438	transferase activity, transferring glycosyl groups
H7849_25250	COG1442	glycosyl transferase family 8
H7849_25265	COG1609	Transcriptional regulator
H7849_25270	COG3250	beta-galactosidase activity
H7849_25295	COG0531	amino acid
H7849_25305	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7849_25315	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_25320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7849_25320	COG2169	Transcriptional regulator
H7849_25325	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7849_25345	COG0577	efflux transmembrane transporter activity
H7849_25360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7849_25375	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7849_25375	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7849_25390	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
H7849_25400	COG1940	carbohydrate kinase activity
H7849_25405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7849_25415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7849_25425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7849_25425	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7849_25430	COG0802	atpase or kinase
H7849_25440	COG4303	Ethanolamine ammonia lyase large subunit
H7849_25445	COG4302	ethanolamine ammonia-lyase activity
H7849_25450	COG5634	Uncharacterized conserved protein (DUF2278)
H7849_25455	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7849_25460	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H7849_25495	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H7849_25515	COG0443	Heat shock 70 kDa protein
H7849_25520	COG2814	Major facilitator Superfamily
H7849_25525	COG4797	methyltransferase
H7849_25525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7849_25540	COG1446	asparaginase
H7849_25545	COG0604	alcohol dehydrogenase
H7849_25555	COG0484	heat shock protein binding
H7849_25565	COG0789	Transcriptional regulator
H7849_25575	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H7849_25580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7849_25600	COG1022	Amp-dependent synthetase and ligase
H7849_25605	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H7849_25615	COG1842	Phage shock protein A
H7849_25620	COG2268	Band 7 protein
H7849_25645	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_25655	COG0730	response to heat
H7849_25665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7849_25665	COG1648	precorrin-2 dehydrogenase activity
H7849_25670	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7849_25720	COG1522	sequence-specific DNA binding
H7849_25730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7849_25735	COG1228	amidohydrolase
H7849_25740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7849_25745	COG1609	Transcriptional regulator
H7849_25800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7849_25805	COG1506	peptidase
H7849_25805	COG4946	Tricorn protease homolog
H7849_25805	COG0823	Involved in the tonB-independent uptake of proteins
H7849_25840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7849_25845	COG0697	spore germination
H7849_25850	COG3206	protein involved in exopolysaccharide biosynthesis
H7849_25850	COG0489	protein tyrosine kinase activity
H7849_25860	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7849_25880	COG3459	Glycosyltransferase 36 associated
H7849_25910	COG3108	Peptidase M15
H7849_25925	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_25940	COG0756	dUTP diphosphatase activity
H7849_25960	COG3534	alpha-L-arabinofuranosidase
H7849_25965	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7849_25980	COG0673	inositol 2-dehydrogenase activity
H7849_25995	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H7849_26000	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7849_26010	COG0531	amino acid
H7849_26040	COG3590	peptidase
H7849_26055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7849_26055	COG2755	lipolytic protein G-D-S-L family
H7849_26095	COG0346	lactoylglutathione lyase activity
H7849_26125	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7849_26130	COG1309	transcriptional regulator
H7849_26150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7849_26155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7849_26160	COG2815	serine threonine protein kinase
H7849_26160	COG0515	serine threonine protein kinase
H7849_26170	COG0335	large ribosomal subunit rRNA binding
H7849_26175	COG0336	Belongs to the RNA methyltransferase TrmD family
H7849_26180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7849_26185	COG1837	Belongs to the UPF0109 family
H7849_26190	COG0228	four-way junction DNA binding
H7849_26215	COG3511	phospholipase C
H7849_26220	COG2132	Multicopper oxidase
H7849_26235	COG1028	Short-chain dehydrogenase reductase Sdr
H7849_26245	COG2271	Major facilitator Superfamily
H7849_26250	COG1904	glucuronate isomerase
H7849_26260	COG3345	alpha-galactosidase
H7849_26280	COG0671	phosphoesterase, PA-phosphatase related
H7849_26290	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7849_26300	COG0154	amidase activity
H7849_26370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7849_26385	COG0823	Involved in the tonB-independent uptake of proteins
H7849_26390	COG1420	regulation of RNA biosynthetic process
H7849_26395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7849_26400	COG0484	heat shock protein binding
H7849_26405	COG1385	rRNA (uridine-N3-)-methyltransferase activity