locus-tag	class	description
Acel_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Acel_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Acel_0002	COG0592	DNA-directed DNA polymerase activity
Acel_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Acel_0005	COG0187	DNA topoisomerase II activity
Acel_0006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Acel_0016	COG3764	Sortase (surface protein transpeptidase)
Acel_0019	COG0515	serine threonine protein kinase
Acel_0019	COG2815	serine threonine protein kinase
Acel_0020	COG0768	penicillin binding
Acel_0023	COG1716	ATPase activity
Acel_0024	COG1716	ATPase activity
Acel_0029	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Acel_0031	COG0508	dehydrogenase complex catalyzes the overall conversion of
Acel_0032	COG0022	dehydrogenase e1 component
Acel_0035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Acel_0041	COG0038	chloride channel
Acel_0045	COG2814	Major facilitator Superfamily
Acel_0047	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Acel_0048	COG4948	Mandelate Racemase Muconate Lactonizing
Acel_0049	COG1017	nitric oxide dioxygenase activity
Acel_0049	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Acel_0052	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Acel_0053	COG0598	Magnesium transport protein CorA
Acel_0056	COG0745	RESPONSE REGULATOR receiver
Acel_0059	COG2897	thiosulfate sulfurtransferase activity
Acel_0063	COG1490	D-aminoacyl-tRNA deacylase activity
Acel_0069	COG0667	Aldo Keto reductase
Acel_0073	COG0297	glycogen (starch) synthase activity
Acel_0075	COG0588	phosphoglycerate mutase activity
Acel_0079	COG4956	integral membrane protein (PIN domain superfamily)
Acel_0080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Acel_0081	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Acel_0082	COG0215	cysteine-tRNA ligase activity
Acel_0083	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Acel_0084	COG3642	lipopolysaccharide core region biosynthetic process
Acel_0088	COG0745	RESPONSE REGULATOR receiver
Acel_0096	COG3706	GGDEF domain
Acel_0101	COG0459	protein refolding
Acel_0103	COG3142	Participates in the control of copper homeostasis
Acel_0104	COG1278	Cold shock
Acel_0105	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Acel_0106	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Acel_0107	COG2814	Major facilitator Superfamily
Acel_0112	COG0667	Aldo Keto reductase
Acel_0114	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Acel_0116	COG0259	pyridoxamine-phosphate oxidase activity
Acel_0118	COG1573	uracil-dna glycosylase
Acel_0128	COG1472	Belongs to the glycosyl hydrolase 3 family
Acel_0131	COG1175	transmembrane transport
Acel_0132	COG0395	ABC-type sugar transport system, permease component
Acel_0144	COG1609	Transcriptional regulator
Acel_0147	COG1250	3-hydroxyacyl-CoA dehydrogenase
Acel_0148	COG0667	Aldo Keto reductase
Acel_0153	COG1131	(ABC) transporter
Acel_0156	COG1970	mechanosensitive ion channel activity
Acel_0158	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Acel_0159	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acel_0164	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Acel_0165	COG3706	GGDEF domain
Acel_0165	COG0745	RESPONSE REGULATOR receiver
Acel_0166	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Acel_0168	COG0315	cyclic pyranopterin monophosphate synthase activity
Acel_0169	COG0521	Mo-molybdopterin cofactor biosynthetic process
Acel_0175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acel_0176	COG0084	hydrolase, TatD family'
Acel_0178	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Acel_0179	COG3509	depolymerase
Acel_0181	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Acel_0190	COG2837	iron assimilation
Acel_0192	COG1131	(ABC) transporter
Acel_0194	COG4585	Histidine kinase
Acel_0195	COG2197	response regulator
Acel_0197	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Acel_0198	COG3883	PFAM NLP P60 protein
Acel_0198	COG0791	NLP P60 protein
Acel_0199	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Acel_0202	COG0037	tRNA processing
Acel_0204	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acel_0205	COG0302	gtp cyclohydrolase
Acel_0206	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Acel_0206	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Acel_0208	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Acel_0208	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Acel_0211	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Acel_0212	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Acel_0213	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Acel_0215	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Acel_0217	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Acel_0220	COG0542	response to heat
Acel_0222	COG2201	protein-glutamate methylesterase activity
Acel_0229	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Acel_0231	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Acel_0235	COG0113	porphobilinogen synthase activity
Acel_0236	COG1648	precorrin-2 dehydrogenase activity
Acel_0236	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Acel_0237	COG0181	hydroxymethylbilane synthase activity
Acel_0238	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Acel_0239	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Acel_0246	COG0123	including yeast histone deacetylase and acetoin utilization protein
Acel_0248	COG0506	proline dehydrogenase activity
Acel_0249	COG1082	Xylose isomerase domain protein TIM barrel
Acel_0250	COG0406	alpha-ribazole phosphatase activity
Acel_0251	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Acel_0252	COG0785	Cytochrome C biogenesis protein
Acel_0255	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Acel_0257	COG0163	prenyltransferase activity
Acel_0259	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Acel_0261	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Acel_0263	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Acel_0264	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Acel_0265	COG2226	methyltransferase
Acel_0266	COG0644	oxidoreductase
Acel_0268	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Acel_0269	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Acel_0270	COG0649	NAD binding
Acel_0273	COG1034	ATP synthesis coupled electron transport
Acel_0274	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Acel_0275	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Acel_0277	COG0713	ATP synthesis coupled electron transport
Acel_0280	COG1007	ATP synthesis coupled electron transport
Acel_0283	COG1013	pyruvate-flavodoxin oxidoreductase activity
Acel_0284	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Acel_0284	COG0674	pyruvate-flavodoxin oxidoreductase activity
Acel_0286	COG1666	GTP binding
Acel_0287	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Acel_0288	COG2030	dehydratase
Acel_0290	COG1309	transcriptional regulator
Acel_0291	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Acel_0292	COG0436	Aminotransferase
Acel_0293	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Acel_0295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Acel_0296	COG0081	regulation of translation
Acel_0297	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Acel_0298	COG0222	ribosome binding
Acel_0299	COG0085	RNA polymerase activity
Acel_0300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Acel_0301	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Acel_0302	COG0049	tRNA binding
Acel_0303	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Acel_0304	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Acel_0305	COG0051	transcription antitermination factor activity, RNA binding
Acel_0306	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Acel_0307	COG0088	Forms part of the polypeptide exit tunnel
Acel_0308	COG0089	rRNA binding
Acel_0309	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Acel_0310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Acel_0311	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Acel_0312	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Acel_0313	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Acel_0314	COG0255	Belongs to the universal ribosomal protein uL29 family
Acel_0315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Acel_0316	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Acel_0317	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Acel_0318	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Acel_0319	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Acel_0320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Acel_0321	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Acel_0322	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Acel_0323	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Acel_0324	COG1841	ribosomal large subunit assembly
Acel_0325	COG0200	Binds to the 23S rRNA
Acel_0327	COG0563	adenylate kinase activity
Acel_0329	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Acel_0330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Acel_0331	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Acel_0332	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Acel_0333	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Acel_0334	COG0202	RNA polymerase activity
Acel_0335	COG0203	ribosomal protein L17
Acel_0336	COG0101	tRNA pseudouridine synthase activity
Acel_0341	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Acel_0342	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Acel_0343	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Acel_0344	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Acel_0346	COG1846	Transcriptional regulator
Acel_0347	COG2409	Drug exporters of the RND superfamily
Acel_0350	COG1595	DNA-templated transcription, initiation
Acel_0352	COG1172	Belongs to the binding-protein-dependent transport system permease family
Acel_0353	COG1129	ABC transporter
Acel_0355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Acel_0356	COG1573	uracil-dna glycosylase
Acel_0357	COG0802	atpase or kinase
Acel_0359	COG1247	-acetyltransferase
Acel_0360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Acel_0362	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Acel_0363	COG0459	protein refolding
Acel_0365	COG2201	protein-glutamate methylesterase activity
Acel_0367	COG0516	GMP reductase activity
Acel_0368	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Acel_0370	COG1605	Chorismate mutase
Acel_0371	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Acel_0371	COG0519	Catalyzes the synthesis of GMP from XMP
Acel_0374	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Acel_0377	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Acel_0377	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Acel_0380	COG0045	succinate-CoA ligase (ADP-forming) activity
Acel_0384	COG0138	bifunctional purine biosynthesis protein purh
Acel_0385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Acel_0389	COG1253	flavin adenine dinucleotide binding
Acel_0390	COG0180	Tryptophanyl-tRNA synthetase
Acel_0392	COG1278	Cold shock
Acel_0393	COG1686	Belongs to the peptidase S11 family
Acel_0395	COG2815	serine threonine protein kinase
Acel_0395	COG0515	serine threonine protein kinase
Acel_0397	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Acel_0400	COG1024	Enoyl-CoA hydratase
Acel_0401	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Acel_0403	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Acel_0405	COG1960	acyl-CoA dehydrogenase activity
Acel_0407	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Acel_0408	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Acel_0410	COG1607	acyl-coa hydrolase
Acel_0411	COG1316	TRANSCRIPTIONal
Acel_0412	COG1316	TRANSCRIPTIONal
Acel_0419	COG0438	transferase activity, transferring glycosyl groups
Acel_0424	COG3858	chitin binding
Acel_0427	COG0438	transferase activity, transferring glycosyl groups
Acel_0428	COG0860	N-Acetylmuramoyl-L-alanine amidase
Acel_0428	COG2247	cell wall binding repeat
Acel_0429	COG1063	alcohol dehydrogenase
Acel_0430	COG1414	Transcriptional regulator
Acel_0435	COG1175	transmembrane transport
Acel_0436	COG0395	ABC-type sugar transport system, permease component
Acel_0437	COG1012	belongs to the aldehyde dehydrogenase family
Acel_0438	COG0463	Glycosyl transferase, family 2
Acel_0447	COG0438	transferase activity, transferring glycosyl groups
Acel_0448	COG0438	transferase activity, transferring glycosyl groups
Acel_0449	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Acel_0450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Acel_0453	COG1834	amidinotransferase
Acel_0454	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Acel_0465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Acel_0466	COG2835	tetraacyldisaccharide 4'-kinase activity
Acel_0468	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Acel_0469	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Acel_0475	COG3480	Lon protease (S16) C-terminal proteolytic domain
Acel_0476	COG0667	Aldo Keto reductase
Acel_0478	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Acel_0479	COG1216	Glycosyl transferase, family 2
Acel_0483	COG2814	Major facilitator Superfamily
Acel_0484	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Acel_0485	COG0697	spore germination
Acel_0486	COG1872	DUF167
Acel_0489	COG0500	methyltransferase
Acel_0490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Acel_0505	COG2271	Major facilitator Superfamily
Acel_0507	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Acel_0508	COG1140	nitrate reductase beta subunit
Acel_0519	COG0589	response to stress
Acel_0520	COG0045	succinate-CoA ligase (ADP-forming) activity
Acel_0520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Acel_0520	COG1042	CoA-binding domain protein
Acel_0521	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Acel_0522	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Acel_0524	COG0425	Belongs to the sulfur carrier protein TusA family
Acel_0530	COG2353	YceI-like domain
Acel_0533	COG0483	inositol monophosphate 1-phosphatase activity
Acel_0534	COG1162	GTPase activity
Acel_0535	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Acel_0536	COG2135	peptidase activity
Acel_0537	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Acel_0538	COG1595	DNA-templated transcription, initiation
Acel_0542	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Acel_0543	COG1937	Protein conserved in bacteria
Acel_0548	COG0439	Biotin carboxylase
Acel_0549	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Acel_0551	COG2188	Transcriptional regulator
Acel_0554	COG0395	ABC-type sugar transport system, permease component
Acel_0555	COG2971	BadF BadG BcrA BcrD
Acel_0556	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Acel_0557	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Acel_0558	COG3842	ATPase activity
Acel_0562	COG4821	SIS domain
Acel_0568	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Acel_0569	COG1053	succinate dehydrogenase
Acel_0571	COG1028	Short-chain dehydrogenase reductase Sdr
Acel_0572	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Acel_0573	COG1940	carbohydrate kinase activity
Acel_0575	COG1846	Transcriptional regulator
Acel_0575	COG1940	carbohydrate kinase activity
Acel_0576	COG4821	SIS domain
Acel_0577	COG1879	ABC-type sugar transport system periplasmic component
Acel_0578	COG1129	ABC transporter
Acel_0579	COG1172	Belongs to the binding-protein-dependent transport system permease family
Acel_0580	COG1172	Belongs to the binding-protein-dependent transport system permease family
Acel_0582	COG1082	Xylose isomerase domain protein TIM barrel
Acel_0583	COG0673	inositol 2-dehydrogenase activity
Acel_0586	COG0567	Dehydrogenase, E1 component
Acel_0586	COG0508	dehydrogenase complex catalyzes the overall conversion of
Acel_0587	COG1876	peptidase activity
Acel_0588	COG0508	dehydrogenase complex catalyzes the overall conversion of
Acel_0589	COG0022	dehydrogenase e1 component
Acel_0590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Acel_0592	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Acel_0593	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Acel_0594	COG1984	allophanate hydrolase subunit 2
Acel_0595	COG2239	Acts as a magnesium transporter
Acel_0596	COG1914	H( )-stimulated, divalent metal cation uptake system
Acel_0597	COG4988	ABC transporter
Acel_0598	COG4988	ABC transporter
Acel_0599	COG1294	oxidase, subunit
Acel_0600	COG1271	oxidase subunit
Acel_0601	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Acel_0604	COG3386	PFAM SMP-30 Gluconolaconase
Acel_0606	COG1846	Transcriptional regulator
Acel_0614	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Acel_0615	COG5297	Belongs to the glycosyl hydrolase family 6
Acel_0615	COG5297	Belongs to the glycosyl hydrolase family 6
Acel_0617	COG4733	cellulase activity
Acel_0617	COG5297	Belongs to the glycosyl hydrolase family 6
Acel_0619	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Acel_0620	COG3706	GGDEF domain
Acel_0620	COG0745	RESPONSE REGULATOR receiver
Acel_0623	COG3189	MarR family transcriptional regulator
Acel_0624	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Acel_0626	COG0183	Belongs to the thiolase family
Acel_0627	COG0745	RESPONSE REGULATOR receiver
Acel_0628	COG0018	arginyl-trna synthetase
Acel_0629	COG0019	diaminopimelate decarboxylase activity
Acel_0630	COG0460	homoserine dehydrogenase
Acel_0631	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Acel_0632	COG0083	homoserine kinase activity
Acel_0634	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Acel_0635	COG1215	transferase activity, transferring glycosyl groups
Acel_0637	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Acel_0638	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Acel_0639	COG1011	Hydrolase
Acel_0640	COG0254	rRNA binding
Acel_0641	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Acel_0642	COG2890	protein-(glutamine-N5) methyltransferase activity
Acel_0647	COG0356	it plays a direct role in the translocation of protons across the membrane
Acel_0649	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Acel_0650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Acel_0651	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Acel_0652	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Acel_0653	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Acel_0654	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Acel_0658	COG1250	3-hydroxyacyl-CoA dehydrogenase
Acel_0659	COG0714	Associated with various cellular activities
Acel_0664	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Acel_0665	COG0746	molybdenum cofactor guanylyltransferase activity
Acel_0667	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Acel_0669	COG0006	proline dipeptidase activity
Acel_0672	COG0183	Belongs to the thiolase family
Acel_0676	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Acel_0677	COG3281	Trehalose synthase
Acel_0678	COG0366	Alpha amylase catalytic
Acel_0679	COG0366	Alpha amylase catalytic
Acel_0680	COG0058	SHG alpha-glucan phosphorylase activity
Acel_0685	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Acel_0689	COG0482	sulfurtransferase activity
Acel_0694	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Acel_0696	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Acel_0697	COG0154	amidase activity
Acel_0698	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Acel_0700	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Acel_0701	COG0674	pyruvate-flavodoxin oxidoreductase activity
Acel_0702	COG1013	pyruvate-flavodoxin oxidoreductase activity
Acel_0705	COG0129	dihydroxy-acid dehydratase activity
Acel_0706	COG0028	Belongs to the TPP enzyme family
Acel_0707	COG0440	acetolactate synthase activity
Acel_0708	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Acel_0709	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Acel_0710	COG0473	3-isopropylmalate dehydrogenase activity
Acel_0711	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Acel_0712	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Acel_0713	COG0179	Fumarylacetoacetate (FAA) hydrolase
Acel_0714	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Acel_0720	COG1349	DNA-binding transcription factor activity
Acel_0721	COG1830	Aldolase
Acel_0723	COG0277	FAD linked oxidase domain protein
Acel_0725	COG0438	transferase activity, transferring glycosyl groups
Acel_0725	COG1216	Glycosyl transferase, family 2
Acel_0726	COG0651	ATP synthesis coupled electron transport
Acel_0727	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Acel_0728	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Acel_0728	COG0649	NAD binding
Acel_0728	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Acel_0729	COG0651	ATP synthesis coupled electron transport
Acel_0733	COG0215	cysteine-tRNA ligase activity
Acel_0735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Acel_0736	COG0544	peptidyl-prolyl cis-trans isomerase activity
Acel_0737	COG0740	serine-type endopeptidase activity
Acel_0738	COG0740	serine-type endopeptidase activity
Acel_0739	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Acel_0741	COG0525	valine-tRNA ligase activity
Acel_0742	COG0285	dihydrofolate synthase activity
Acel_0744	COG1131	(ABC) transporter
Acel_0745	COG0842	Transport permease protein
Acel_0747	COG0105	UTP biosynthetic process
Acel_0748	COG1077	Cell shape determining protein MreB Mrl
Acel_0751	COG0768	penicillin binding
Acel_0752	COG0772	Belongs to the SEDS family
Acel_0755	COG1530	ribonuclease E activity
Acel_0756	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Acel_0757	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Acel_0758	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Acel_0759	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Acel_0761	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Acel_0762	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Acel_0766	COG1968	undecaprenyl-diphosphatase activity
Acel_0767	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Acel_0768	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
Acel_0769	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Acel_0771	COG0495	leucyl-tRNA aminoacylation
Acel_0772	COG1307	EDD domain protein, DegV family
Acel_0773	COG1596	polysaccharide export
Acel_0773	COG1555	photosystem II stabilization
Acel_0776	COG0268	Binds directly to 16S ribosomal RNA
Acel_0778	COG0481	GTPase activity
Acel_0779	COG2258	MOSC domain
Acel_0783	COG1420	regulation of RNA biosynthetic process
Acel_0784	COG0484	heat shock protein binding
Acel_0788	COG0537	adenosine 5'-monophosphoramidase activity
Acel_0790	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Acel_0794	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Acel_0795	COG1381	Involved in DNA repair and RecF pathway recombination
Acel_0796	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Acel_0798	COG0423	glycine-tRNA ligase activity
Acel_0801	COG0574	Belongs to the PEP-utilizing enzyme family
Acel_0801	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Acel_0802	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Acel_0805	COG0384	phenazine biosynthesis protein PhzF
Acel_0816	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Acel_0825	COG2323	membrane
Acel_0828	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Acel_0829	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Acel_0830	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Acel_0831	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Acel_0832	COG4786	Flagellar basal body rod
Acel_0832	COG1256	bacterial-type flagellum assembly
Acel_0838	COG1815	bacterial-type flagellum-dependent cell motility
Acel_0839	COG1558	bacterial-type flagellum-dependent cell motility
Acel_0840	COG1677	Flagellar hook-basal body complex protein FliE
Acel_0841	COG1766	The M ring may be actively involved in energy transduction
Acel_0844	COG1157	protein secretion by the type III secretion system
Acel_0846	COG0741	lytic transglycosylase activity
Acel_0854	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Acel_0855	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Acel_0857	COG1338	Plays a role in the flagellum-specific transport system
Acel_0858	COG1987	bacterial-type flagellum assembly
Acel_0859	COG1684	flagellar biosynthetic protein fliR
Acel_0861	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Acel_0866	COG0492	ferredoxin-NADP+ reductase activity
Acel_0869	COG0861	Integral membrane protein TerC family
Acel_0870	COG1609	Transcriptional regulator
Acel_0873	COG2160	L-arabinose isomerase activity
Acel_0876	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Acel_0877	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Acel_0883	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acel_0885	COG0251	oxidation-reduction process
Acel_0887	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Acel_0896	COG2080	2 iron, 2 sulfur cluster binding
Acel_0897	COG2010	Cytochrome c
Acel_0897	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Acel_0898	COG2084	Dehydrogenase
Acel_0902	COG0406	alpha-ribazole phosphatase activity
Acel_0902	COG0328	RNA-DNA hybrid ribonuclease activity
Acel_0905	COG0246	Mannitol dehydrogenase
Acel_0910	COG0410	ABC transporter
Acel_0912	COG1881	PFAM PEBP family protein
Acel_0915	COG0586	Pfam SNARE associated Golgi protein
Acel_0917	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Acel_0918	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Acel_0918	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acel_0919	COG0174	glutamine synthetase
Acel_0920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Acel_0926	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Acel_0927	COG0321	lipoyl(octanoyl) transferase activity
Acel_0932	COG5001	Diguanylate cyclase
Acel_0936	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Acel_0937	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Acel_0938	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Acel_0943	COG3845	ABC transporter
Acel_0944	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Acel_0948	COG0667	Aldo Keto reductase
Acel_0952	COG0501	Belongs to the peptidase M48B family
Acel_0956	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Acel_0957	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Acel_0961	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Acel_0962	COG0723	plastoquinol--plastocyanin reductase activity
Acel_0963	COG2010	Cytochrome c
Acel_0964	COG1845	cytochrome c oxidase, subunit III
Acel_0966	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Acel_0971	COG0791	NLP P60 protein
Acel_0971	COG3103	Sh3 type 3 domain protein
Acel_0971	COG1388	LysM domain
Acel_0972	COG0438	transferase activity, transferring glycosyl groups
Acel_0974	COG3850	Histidine kinase
Acel_0979	COG1940	carbohydrate kinase activity
Acel_0982	COG0204	Acyl-transferase
Acel_0983	COG0205	6-phosphofructokinase activity
Acel_0984	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Acel_0985	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Acel_0986	COG2815	serine threonine protein kinase
Acel_0986	COG0515	serine threonine protein kinase
Acel_0987	COG2022	thiamine diphosphate biosynthetic process
Acel_0989	COG2022	thiamine diphosphate biosynthetic process
Acel_0989	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acel_0990	COG0352	thiamine-phosphate diphosphorylase activity
Acel_0992	COG0442	prolyl-tRNA aminoacylation
Acel_1000	COG0714	Associated with various cellular activities
Acel_1001	COG2001	Belongs to the MraZ family
Acel_1002	COG0275	rRNA processing
Acel_1004	COG0768	penicillin binding
Acel_1005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Acel_1007	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Acel_1008	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Acel_1010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Acel_1011	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Acel_1012	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Acel_1014	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Acel_1017	COG0543	2 iron, 2 sulfur cluster binding
Acel_1021	COG0375	protein maturation
Acel_1024	COG1799	cell septum assembly
Acel_1027	COG3599	regulation of cell shape
Acel_1029	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Acel_1030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Acel_1031	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Acel_1034	COG0432	Pfam Uncharacterised protein family UPF0047
Acel_1035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Acel_1037	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Acel_1040	COG1028	Short-chain dehydrogenase reductase Sdr
Acel_1042	COG0402	S-adenosylhomocysteine deaminase activity
Acel_1043	COG0006	proline dipeptidase activity
Acel_1045	COG2084	Dehydrogenase
Acel_1046	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Acel_1047	COG0022	dehydrogenase e1 component
Acel_1048	COG0508	dehydrogenase complex catalyzes the overall conversion of
Acel_1050	COG1129	ABC transporter
Acel_1052	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Acel_1053	COG0156	8-amino-7-oxononanoate synthase activity
Acel_1058	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Acel_1059	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Acel_1060	COG0131	Imidazoleglycerol-phosphate dehydratase
Acel_1061	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Acel_1062	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Acel_1063	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Acel_1065	COG3279	Response regulator of the LytR AlgR family
Acel_1067	COG1584	GPR1 FUN34 yaaH family protein
Acel_1068	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Acel_1069	COG0107	imidazoleglycerol-phosphate synthase activity
Acel_1070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Acel_1071	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Acel_1073	COG0134	indole-3-glycerol-phosphate synthase activity
Acel_1074	COG0133	tryptophan synthase activity
Acel_1075	COG0159	tryptophan synthase activity
Acel_1076	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Acel_1078	COG0069	glutamate synthase activity
Acel_1078	COG0070	glutamate synthase
Acel_1078	COG0067	glutamate synthase
Acel_1083	COG0559	Belongs to the binding-protein-dependent transport system permease family
Acel_1086	COG0410	ABC transporter
Acel_1091	COG0237	dephospho-CoA kinase activity
Acel_1094	COG0519	Catalyzes the synthesis of GMP from XMP
Acel_1094	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Acel_1096	COG0174	glutamine synthetase
Acel_1099	COG0519	Catalyzes the synthesis of GMP from XMP
Acel_1099	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Acel_1101	COG2078	PFAM AMMECR1 domain protein
Acel_1101	COG3885	ferrous iron binding
Acel_1102	COG0179	Fumarylacetoacetate (FAA) hydrolase
Acel_1106	COG0556	nucleotide-excision repair
Acel_1107	COG4552	Acetyltransferase involved in intracellular survival and related
Acel_1109	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Acel_1110	COG0322	excinuclease ABC activity
Acel_1111	COG1660	Displays ATPase and GTPase activities
Acel_1112	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Acel_1113	COG1481	regulation of sporulation
Acel_1114	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Acel_1115	COG0149	triose-phosphate isomerase activity
Acel_1115	COG0126	phosphoglycerate kinase activity
Acel_1120	COG4608	Belongs to the ABC transporter superfamily
Acel_1121	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Acel_1122	COG0363	glucosamine-6-phosphate deaminase activity
Acel_1125	COG0166	Belongs to the GPI family
Acel_1126	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Acel_1127	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Acel_1128	COG0109	protoheme IX farnesyltransferase activity
Acel_1129	COG1940	carbohydrate kinase activity
Acel_1130	COG4214	carbohydrate transport
Acel_1137	COG0396	ATPase activity
Acel_1138	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Acel_1139	COG0822	iron-sulfur transferase activity
Acel_1140	COG2151	metal-sulfur cluster biosynthetic enzyme
Acel_1142	COG1132	(ABC) transporter
Acel_1143	COG3387	PFAM Glycoside hydrolase 15-related
Acel_1147	COG3360	Dodecin
Acel_1152	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Acel_1153	COG1388	LysM domain
Acel_1154	COG1119	ATPase activity
Acel_1157	COG0739	heme binding
Acel_1160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Acel_1161	COG3706	GGDEF domain
Acel_1162	COG2223	nitrite transmembrane transporter activity
Acel_1164	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Acel_1165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acel_1168	COG0667	Aldo Keto reductase
Acel_1172	COG0215	cysteine-tRNA ligase activity
Acel_1174	COG0646	methionine synthase
Acel_1174	COG1410	methionine synthase
Acel_1175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Acel_1178	COG0577	efflux transmembrane transporter activity
Acel_1179	COG1136	(ABC) transporter
Acel_1181	COG1994	Peptidase M50
Acel_1181	COG0517	IMP dehydrogenase activity
Acel_1184	COG1222	aaa ATPase
Acel_1186	COG4122	O-methyltransferase activity
Acel_1188	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Acel_1189	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Acel_1191	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Acel_1192	COG0318	PFAM AMP-dependent synthetase and ligase
Acel_1193	COG1960	acyl-CoA dehydrogenase activity
Acel_1197	COG1028	Short-chain dehydrogenase reductase Sdr
Acel_1198	COG1902	pentaerythritol trinitrate reductase activity
Acel_1198	COG0446	pyridine nucleotide-disulphide oxidoreductase
Acel_1199	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Acel_1204	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Acel_1205	COG0805	protein transport
Acel_1207	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Acel_1208	COG1960	acyl-CoA dehydrogenase activity
Acel_1210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Acel_1211	COG0463	Glycosyl transferase, family 2
Acel_1213	COG0800	Aldolase
Acel_1218	COG2807	transmembrane transport
Acel_1222	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Acel_1222	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Acel_1231	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Acel_1233	COG1160	GTP binding
Acel_1234	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Acel_1235	COG0287	Prephenate dehydrogenase
Acel_1237	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Acel_1238	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Acel_1239	COG1994	Peptidase M50
Acel_1243	COG0504	CTP synthase activity
Acel_1245	COG0497	DNA recombination
Acel_1246	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Acel_1250	COG0647	UMP catabolic process
Acel_1254	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Acel_1255	COG2094	Belongs to the DNA glycosylase MPG family
Acel_1256	COG0165	Argininosuccinate lyase
Acel_1257	COG0137	argininosuccinate synthase activity
Acel_1258	COG1438	arginine binding
Acel_1259	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Acel_1261	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Acel_1262	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Acel_1263	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Acel_1264	COG0072	phenylalanine-tRNA ligase activity
Acel_1264	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acel_1265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Acel_1267	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Acel_1268	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Acel_1269	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Acel_1270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Acel_1271	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Acel_1272	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Acel_1272	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Acel_1276	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Acel_1278	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Acel_1279	COG0242	peptide deformylase activity
Acel_1280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acel_1281	COG1177	transmembrane transport
Acel_1282	COG1176	ABC-type spermidine putrescine transport system, permease component I
Acel_1284	COG3842	ATPase activity
Acel_1285	COG1012	belongs to the aldehyde dehydrogenase family
Acel_1287	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Acel_1290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Acel_1292	COG1758	RNA polymerase activity
Acel_1293	COG0194	GDP metabolic process
Acel_1295	COG0284	orotidine-5'-phosphate decarboxylase activity
Acel_1296	COG0167	dihydroorotate dehydrogenase activity
Acel_1297	COG0543	2 iron, 2 sulfur cluster binding
Acel_1298	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Acel_1299	COG0505	Belongs to the CarA family
Acel_1300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Acel_1301	COG0540	Belongs to the ATCase OTCase family
Acel_1302	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Acel_1304	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Acel_1305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Acel_1306	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Acel_1307	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Acel_1308	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Acel_1309	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Acel_1314	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Acel_1318	COG4968	Prepilin-type N-terminal cleavage methylation domain
Acel_1319	COG4968	Prepilin-type N-terminal cleavage methylation domain
Acel_1322	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Acel_1327	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Acel_1328	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Acel_1330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Acel_1334	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Acel_1335	COG0124	histidyl-tRNA synthetase
Acel_1337	COG0545	Peptidyl-prolyl cis-trans isomerase
Acel_1338	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Acel_1339	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Acel_1340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Acel_1343	COG2255	four-way junction helicase activity
Acel_1344	COG0632	four-way junction helicase activity
Acel_1345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Acel_1346	COG0217	transcriptional regulatory protein
Acel_1347	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Acel_1348	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Acel_1353	COG0438	transferase activity, transferring glycosyl groups
Acel_1354	COG1560	Kdo2-lipid A biosynthetic process
Acel_1358	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Acel_1359	COG1609	Transcriptional regulator
Acel_1361	COG1175	transmembrane transport
Acel_1362	COG0395	ABC-type sugar transport system, permease component
Acel_1367	COG0842	Transport permease protein
Acel_1367	COG1129	ABC transporter
Acel_1376	COG1793	dna ligase
Acel_1379	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Acel_1382	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Acel_1385	COG4152	abc transporter atp-binding protein
Acel_1387	COG3851	Histidine kinase
Acel_1389	COG1404	Belongs to the peptidase S8 family
Acel_1390	COG2197	response regulator
Acel_1391	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Acel_1393	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Acel_1394	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Acel_1396	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Acel_1397	COG0531	amino acid
Acel_1398	COG0569	domain protein
Acel_1402	COG0756	dUTP diphosphatase activity
Acel_1406	COG0823	Involved in the tonB-independent uptake of proteins
Acel_1406	COG1506	peptidase
Acel_1421	COG0501	Belongs to the peptidase M48B family
Acel_1422	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Acel_1423	COG0412	Dienelactone hydrolase
Acel_1425	COG0626	cystathionine gamma-synthase activity
Acel_1427	COG0187	DNA topoisomerase II activity
Acel_1430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Acel_1439	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Acel_1440	COG2151	metal-sulfur cluster biosynthetic enzyme
Acel_1441	COG3396	Phenylacetate-CoA oxygenase
Acel_1442	COG3460	Phenylacetate-CoA oxygenase
Acel_1443	COG3396	Phenylacetate-CoA oxygenase
Acel_1444	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Acel_1446	COG0215	cysteine-tRNA ligase activity
Acel_1448	COG2205	protein histidine kinase activity
Acel_1449	COG0745	RESPONSE REGULATOR receiver
Acel_1451	COG1136	(ABC) transporter
Acel_1452	COG0577	efflux transmembrane transporter activity
Acel_1452	COG1136	(ABC) transporter
Acel_1454	COG0673	inositol 2-dehydrogenase activity
Acel_1457	COG2755	lipolytic protein G-D-S-L family
Acel_1457	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Acel_1470	COG0277	FAD linked oxidase domain protein
Acel_1474	COG0071	Belongs to the small heat shock protein (HSP20) family
Acel_1477	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Acel_1479	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Acel_1482	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Acel_1483	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Acel_1484	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Acel_1486	COG1196	nuclear chromosome segregation
Acel_1487	COG0860	N-Acetylmuramoyl-L-alanine amidase
Acel_1487	COG2247	cell wall binding repeat
Acel_1488	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Acel_1490	COG1418	mRNA catabolic process
Acel_1491	COG2137	regulation of response to DNA damage stimulus
Acel_1492	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Acel_1494	COG1595	DNA-templated transcription, initiation
Acel_1496	COG1201	RNA secondary structure unwinding
Acel_1497	COG1546	Belongs to the CinA family
Acel_1497	COG1058	Belongs to the CinA family
Acel_1499	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Acel_1501	COG1674	ftsk spoiiie
Acel_1502	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Acel_1503	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Acel_1504	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Acel_1506	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Acel_1507	COG0612	Peptidase, M16
Acel_1508	COG1185	polyribonucleotide nucleotidyltransferase activity
Acel_1509	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Acel_1512	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Acel_1513	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Acel_1515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Acel_1518	COG0779	Required for maturation of 30S ribosomal subunits
Acel_1519	COG0442	prolyl-tRNA aminoacylation
Acel_1522	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Acel_1523	COG0750	zinc metalloprotease
Acel_1532	COG0673	inositol 2-dehydrogenase activity
Acel_1533	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Acel_1536	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Acel_1537	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Acel_1538	COG0575	Belongs to the CDS family
Acel_1539	COG0233	cytoplasmic translational termination
Acel_1540	COG0528	UMP kinase activity
Acel_1541	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Acel_1542	COG0052	Belongs to the universal ribosomal protein uS2 family
Acel_1546	COG1191	sigma factor activity
Acel_1549	COG0606	chelatase, subunit chli
Acel_1550	COG0792	nuclease activity
Acel_1551	COG4106	trans-aconitate 2-methyltransferase activity
Acel_1554	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Acel_1557	COG0335	large ribosomal subunit rRNA binding
Acel_1558	COG0336	Belongs to the RNA methyltransferase TrmD family
Acel_1559	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Acel_1560	COG1837	Belongs to the UPF0109 family
Acel_1561	COG0228	four-way junction DNA binding
Acel_1564	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Acel_1572	COG1254	Belongs to the acylphosphatase family
Acel_1573	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Acel_1574	COG0571	ribonuclease III activity
Acel_1575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Acel_1578	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Acel_1579	COG0742	ribosomal rna small subunit methyltransferase
Acel_1581	COG1461	Dihydroxyacetone kinase
Acel_1582	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Acel_1583	COG0351	phosphomethylpyrimidine kinase
Acel_1586	COG1181	Belongs to the D-alanine--D-alanine ligase family
Acel_1587	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Acel_1589	COG0776	regulation of translation
Acel_1590	COG0066	3-isopropylmalate dehydratase activity
Acel_1591	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Acel_1592	COG1414	Transcriptional regulator
Acel_1593	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Acel_1594	COG2205	protein histidine kinase activity
Acel_1595	COG0745	RESPONSE REGULATOR receiver
Acel_1598	COG0698	ribose 5-phosphate isomerase
Acel_1604	COG1505	serine-type exopeptidase activity
Acel_1605	COG2205	protein histidine kinase activity
Acel_1606	COG0745	RESPONSE REGULATOR receiver
Acel_1608	COG1764	response to oxidative stress
Acel_1616	COG1648	precorrin-2 dehydrogenase activity
Acel_1616	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Acel_1619	COG0529	Catalyzes the synthesis of activated sulfate
Acel_1620	COG0629	single-stranded DNA binding
Acel_1626	COG0577	efflux transmembrane transporter activity
Acel_1626	COG1136	(ABC) transporter
Acel_1627	COG0577	efflux transmembrane transporter activity
Acel_1627	COG1136	(ABC) transporter
Acel_1628	COG1803	Methylglyoxal synthase
Acel_1631	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Acel_1631	COG3608	succinylglutamate desuccinylase aspartoacylase
Acel_1635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Acel_1641	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acel_1642	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Acel_1643	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Acel_1644	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Acel_1645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Acel_1648	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Acel_1649	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Acel_1650	COG1937	Protein conserved in bacteria
Acel_1657	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Acel_1660	COG2050	protein possibly involved in aromatic compounds catabolism
Acel_1662	COG5001	Diguanylate cyclase
Acel_1662	COG3300	MHYT domain
Acel_1665	COG0302	gtp cyclohydrolase
Acel_1667	COG3547	Transposase (IS116 IS110 IS902 family)
Acel_1674	COG2017	converts alpha-aldose to the beta-anomer
Acel_1677	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Acel_1681	COG1063	alcohol dehydrogenase
Acel_1683	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Acel_1684	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Acel_1685	COG1234	tRNA 3'-trailer cleavage
Acel_1686	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Acel_1693	COG1562	ergosterol biosynthetic process
Acel_1695	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Acel_1697	COG1657	PFAM Prenyltransferase squalene oxidase
Acel_1699	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Acel_1702	COG1470	cell adhesion involved in biofilm formation
Acel_1704	COG1678	Uncharacterized ACR, COG1678
Acel_1705	COG1492	cobalamin metabolic process
Acel_1709	COG1309	transcriptional regulator
Acel_1711	COG1028	Short-chain dehydrogenase reductase Sdr
Acel_1713	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Acel_1714	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Acel_1715	COG0667	Aldo Keto reductase
Acel_1717	COG1335	isochorismatase
Acel_1720	COG2814	Major facilitator Superfamily
Acel_1723	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Acel_1724	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Acel_1724	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Acel_1725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Acel_1728	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Acel_1729	COG0793	Belongs to the peptidase S41A family
Acel_1730	COG2177	Part of the ABC transporter FtsEX involved in
Acel_1731	COG2884	Cell division ATP-binding protein ftsE
Acel_1732	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Acel_1741	COG1674	ftsk spoiiie
Acel_1743	COG2146	nitrite reductase [NAD(P)H] activity
Acel_1744	COG2146	nitrite reductase [NAD(P)H] activity
Acel_1744	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Acel_1746	COG0243	molybdopterin cofactor binding
Acel_1747	COG2223	nitrite transmembrane transporter activity
Acel_1749	COG2902	Dehydrogenase
Acel_1750	COG1012	belongs to the aldehyde dehydrogenase family
Acel_1759	COG0653	protein targeting
Acel_1760	COG2197	response regulator
Acel_1761	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Acel_1763	COG5401	PFAM Sporulation and spore germination
Acel_1764	COG5002	protein histidine kinase activity
Acel_1764	COG5000	phosphorelay sensor kinase activity
Acel_1765	COG0745	RESPONSE REGULATOR receiver
Acel_1769	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Acel_1771	COG0210	DNA helicase
Acel_1773	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acel_1776	COG0210	DNA helicase
Acel_1788	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Acel_1789	COG2201	protein-glutamate methylesterase activity
Acel_1792	COG0835	chemotaxis
Acel_1793	COG2198	Histidine kinase
Acel_1793	COG0643	Histidine kinase
Acel_1795	COG2095	MarC family integral membrane protein
Acel_1800	COG3962	Belongs to the TPP enzyme family
Acel_1801	COG3718	enzyme involved in inositol metabolism
Acel_1803	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Acel_1805	COG0673	inositol 2-dehydrogenase activity
Acel_1807	COG1172	Belongs to the binding-protein-dependent transport system permease family
Acel_1809	COG0673	inositol 2-dehydrogenase activity
Acel_1810	COG1082	Xylose isomerase domain protein TIM barrel
Acel_1812	COG1082	Xylose isomerase domain protein TIM barrel
Acel_1814	COG0673	inositol 2-dehydrogenase activity
Acel_1815	COG1028	Short-chain dehydrogenase reductase Sdr
Acel_1818	COG2239	Acts as a magnesium transporter
Acel_1820	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Acel_1821	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Acel_1822	COG0297	glycogen (starch) synthase activity
Acel_1824	COG2151	metal-sulfur cluster biosynthetic enzyme
Acel_1824	COG0489	protein tyrosine kinase activity
Acel_1826	COG1595	DNA-templated transcription, initiation
Acel_1828	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Acel_1828	COG0512	Glutamine amidotransferase of anthranilate synthase
Acel_1829	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Acel_1831	COG5002	protein histidine kinase activity
Acel_1832	COG0745	RESPONSE REGULATOR receiver
Acel_1834	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Acel_1836	COG1024	Enoyl-CoA hydratase
Acel_1837	COG0519	Catalyzes the synthesis of GMP from XMP
Acel_1839	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Acel_1841	COG1611	Belongs to the LOG family
Acel_1843	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acel_1844	COG2171	N-acyltransferase activity
Acel_1846	COG1760	l-serine dehydratase
Acel_1847	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Acel_1848	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Acel_1849	COG1028	Short-chain dehydrogenase reductase Sdr
Acel_1850	COG1012	belongs to the aldehyde dehydrogenase family
Acel_1851	COG0174	glutamine synthetase
Acel_1852	COG2186	Transcriptional regulator
Acel_1854	COG2971	BadF BadG BcrA BcrD
Acel_1858	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Acel_1860	COG1322	Protein conserved in bacteria
Acel_1861	COG0012	GTP binding
Acel_1862	COG2154	pterin-4-alpha-carbinolamine dehydratase
Acel_1868	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Acel_1869	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acel_1872	COG0840	transmembrane signaling receptor activity
Acel_1873	COG2198	Histidine kinase
Acel_1873	COG0643	Histidine kinase
Acel_1874	COG0745	RESPONSE REGULATOR receiver
Acel_1875	COG1570	exodeoxyribonuclease VII activity
Acel_1876	COG1722	exodeoxyribonuclease VII activity
Acel_1879	COG0114	fumarate hydratase activity
Acel_1881	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Acel_1883	COG1331	Highly conserved protein containing a thioredoxin domain
Acel_1884	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Acel_1886	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Acel_1887	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Acel_1888	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Acel_1893	COG4867	von Willebrand factor, type A
Acel_1898	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Acel_1909	COG0148	phosphopyruvate hydratase activity
Acel_1911	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Acel_1920	COG0438	transferase activity, transferring glycosyl groups
Acel_1929	COG0438	transferase activity, transferring glycosyl groups
Acel_1931	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Acel_1932	COG1216	Glycosyl transferase, family 2
Acel_1934	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Acel_1941	COG0579	oxidoreductase
Acel_1943	COG0736	holo-[acyl-carrier-protein] synthase activity
Acel_1944	COG0193	aminoacyl-tRNA hydrolase activity
Acel_1945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Acel_1946	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Acel_1947	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Acel_1948	COG1741	Belongs to the pirin family
Acel_1949	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Acel_1950	COG1518	maintenance of DNA repeat elements
Acel_1957	COG0730	response to heat
Acel_1962	COG0778	Nitroreductase
Acel_1962	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Acel_1964	COG1774	PSP1 C-terminal conserved region
Acel_1970	COG0470	DNA polymerase III
Acel_1971	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Acel_1972	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Acel_1972	COG1754	DNA topoisomerase type I activity
Acel_1973	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Acel_1975	COG1366	Belongs to the anti-sigma-factor antagonist family
Acel_1976	COG1205	dead DEAH box helicase
Acel_1976	COG1111	helicase
Acel_1984	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Acel_1985	COG3263	regulation of cellular component size
Acel_1990	COG0596	Alpha beta hydrolase
Acel_1997	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Acel_2002	COG0003	Pfam Anion-transporting ATPase
Acel_2004	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Acel_2005	COG1610	YqeY-like protein
Acel_2006	COG1408	metallophosphoesterase
Acel_2007	COG0783	Belongs to the Dps family
Acel_2015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Acel_2020	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Acel_2021	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Acel_2022	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Acel_2025	COG0745	RESPONSE REGULATOR receiver
Acel_2026	COG0456	acetyltransferase
Acel_2026	COG0454	-acetyltransferase
Acel_2032	COG1191	sigma factor activity
Acel_2033	COG3469	chitinase activity
Acel_2045	COG3458	cephalosporin-C deacetylase activity
Acel_2046	COG1609	Transcriptional regulator
Acel_2048	COG1175	transmembrane transport
Acel_2049	COG1653	transport
Acel_2052	COG0215	cysteine-tRNA ligase activity
Acel_2054	COG0175	sulfate reduction
Acel_2055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Acel_2059	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Acel_2064	COG2115	Belongs to the xylose isomerase family
Acel_2065	COG1070	Carbohydrate kinase
Acel_2071	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Acel_2074	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Acel_2075	COG0047	phosphoribosylformylglycinamidine synthase activity
Acel_2076	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Acel_2083	COG0305	Participates in initiation and elongation during chromosome replication
Acel_2088	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Acel_2099	COG3287	FIST C domain
Acel_2099	COG2199	diguanylate cyclase activity
Acel_2099	COG2200	EAL domain
Acel_2100	COG2205	protein histidine kinase activity
Acel_2103	COG0561	phosphatase activity
Acel_2104	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Acel_2105	COG0077	Prephenate dehydratase
Acel_2109	COG0393	Putative heavy-metal-binding
Acel_2112	COG0717	Belongs to the dCTP deaminase family
Acel_2113	COG2181	nitrate reductase activity
Acel_2113	COG0247	lactate metabolic process
Acel_2115	COG0443	Heat shock 70 kDa protein
Acel_2116	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Acel_2117	COG0484	heat shock protein binding
Acel_2118	COG0789	Transcriptional regulator
Acel_2119	COG0542	response to heat
Acel_2120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Acel_2122	COG1028	Short-chain dehydrogenase reductase Sdr
Acel_2123	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Acel_2124	COG0586	Pfam SNARE associated Golgi protein
Acel_2126	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Acel_2127	COG0151	Belongs to the GarS family
Acel_2128	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Acel_2129	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Acel_2130	COG0359	binds to the 23S rRNA
Acel_2131	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Acel_2133	COG0360	Binds together with S18 to 16S ribosomal RNA
Acel_2135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Acel_2139	COG0617	tRNA 3'-terminal CCA addition
Acel_2146	COG1595	DNA-templated transcription, initiation
Acel_2149	COG3118	belongs to the thioredoxin family
Acel_2152	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acel_2153	COG1181	Belongs to the D-alanine--D-alanine ligase family
Acel_2155	COG1192	Involved in chromosome partitioning
Acel_2156	COG0357	Ribosomal RNA small subunit methyltransferase G
Acel_2158	COG0706	membrane insertase activity
Acel_2160	COG0594	ribonuclease P activity
Acel_2161	COG0230	Belongs to the bacterial ribosomal protein bL34 family