locus-tag	class	description
HUK68_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUK68_00010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUK68_00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUK68_00025	COG0706	membrane insertase activity
HUK68_00030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HUK68_00050	COG4948	Mandelate Racemase Muconate Lactonizing
HUK68_00070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUK68_00090	COG0300	oxidoreductase activity
HUK68_00095	COG0724	RNA recognition motif
HUK68_00105	COG0724	RNA recognition motif
HUK68_00110	COG2119	membrane
HUK68_00115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUK68_00130	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUK68_00140	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HUK68_00145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUK68_00150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUK68_00195	COG0482	sulfurtransferase activity
HUK68_00225	COG5507	3-demethylubiquinone-9 3-methyltransferase
HUK68_00270	COG0629	single-stranded DNA binding
HUK68_00275	COG2814	Major facilitator Superfamily
HUK68_00290	COG0584	glycerophosphoryl diester phosphodiesterase
HUK68_00300	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_00305	COG0583	DNA-binding transcription factor activity
HUK68_00310	COG0284	orotidine-5'-phosphate decarboxylase activity
HUK68_00315	COG0126	phosphoglycerate kinase activity
HUK68_00330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUK68_00340	COG0242	peptide deformylase activity
HUK68_00355	COG0758	DNA mediated transformation
HUK68_00370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUK68_00375	COG1862	Preprotein translocase
HUK68_00385	COG1522	sequence-specific DNA binding
HUK68_00390	COG2814	Major facilitator Superfamily
HUK68_00400	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HUK68_00410	COG2885	chlorophyll binding
HUK68_00435	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUK68_00440	COG0625	glutathione transferase activity
HUK68_00465	COG0861	Integral membrane protein TerC family
HUK68_00475	COG1950	PFAM Membrane protein of
HUK68_00480	COG4783	chaperone-mediated protein folding
HUK68_00485	COG0315	cyclic pyranopterin monophosphate synthase activity
HUK68_00490	COG4969	Belongs to the N-Me-Phe pilin family
HUK68_00510	COG0631	protein serine/threonine phosphatase activity
HUK68_00515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUK68_00520	COG0045	succinate-CoA ligase (ADP-forming) activity
HUK68_00525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUK68_00530	COG2137	regulation of response to DNA damage stimulus
HUK68_00535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUK68_00550	COG0642	Histidine kinase
HUK68_00590	COG2365	Tyrosine phosphatase family
HUK68_00595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUK68_00600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUK68_00615	COG3148	PFAM DTW domain containing protein
HUK68_00630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUK68_00630	COG2755	lipolytic protein G-D-S-L family
HUK68_00655	COG0625	glutathione transferase activity
HUK68_00670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUK68_00700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUK68_00705	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HUK68_00710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUK68_00715	COG0006	proline dipeptidase activity
HUK68_00725	COG0469	pyruvate kinase activity
HUK68_00740	COG0318	PFAM AMP-dependent synthetase and ligase
HUK68_00745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUK68_00750	COG0598	Magnesium transport protein CorA
HUK68_00760	COG0456	acetyltransferase
HUK68_00765	COG1214	PFAM Peptidase M22, glycoprotease
HUK68_00785	COG0009	L-threonylcarbamoyladenylate synthase
HUK68_00790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUK68_00795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUK68_00800	COG3118	belongs to the thioredoxin family
HUK68_00805	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUK68_00810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUK68_00820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HUK68_00825	COG0735	belongs to the Fur family
HUK68_00830	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUK68_00835	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUK68_00850	COG0668	transmembrane transport
HUK68_00855	COG0495	leucyl-tRNA aminoacylation
HUK68_00875	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUK68_00880	COG0569	domain protein
HUK68_00885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUK68_00895	COG3158	transport of potassium into the cell
HUK68_00900	COG3135	benzoate transporter
HUK68_00905	COG0189	ligase activity
HUK68_00960	COG0121	glutamine amidotransferase
HUK68_00965	COG1942	4-Oxalocrotonate Tautomerase
HUK68_00975	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HUK68_00980	COG0583	DNA-binding transcription factor activity
HUK68_00990	COG0018	arginyl-trna synthetase
HUK68_01000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUK68_01005	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HUK68_01010	COG1137	ATPase activity
HUK68_01015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HUK68_01030	COG0653	protein targeting
HUK68_01035	COG0659	secondary active sulfate transmembrane transporter activity
HUK68_01040	COG1546	Belongs to the CinA family
HUK68_01045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HUK68_01055	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUK68_01070	COG2967	ApaG domain
HUK68_01075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUK68_01080	COG0546	phosphoglycolate phosphatase activity
HUK68_01095	COG0512	Glutamine amidotransferase of anthranilate synthase
HUK68_01100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUK68_01105	COG0134	indole-3-glycerol-phosphate synthase activity
HUK68_01110	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUK68_01120	COG4607	ABC-type enterochelin transport system periplasmic component
HUK68_01125	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUK68_01130	COG4605	iron ion homeostasis
HUK68_01135	COG4604	ABC transporter, ATP-binding protein
HUK68_01140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUK68_01150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUK68_01160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUK68_01170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUK68_01180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUK68_01185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUK68_01190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUK68_01195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUK68_01200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUK68_01205	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUK68_01210	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUK68_01215	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUK68_01220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUK68_01225	COG1841	ribosomal large subunit assembly
HUK68_01230	COG0200	Binds to the 23S rRNA
HUK68_01235	COG0201	protein transport
HUK68_01240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUK68_01245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUK68_01250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUK68_01255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUK68_01260	COG0202	RNA polymerase activity
HUK68_01265	COG0203	ribosomal protein L17
HUK68_01275	COG0443	Heat shock 70 kDa protein
HUK68_01280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUK68_01290	COG0792	nuclease activity
HUK68_01295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUK68_01300	COG2823	Periplasmic or secreted lipoprotein
HUK68_01305	COG2084	Dehydrogenase
HUK68_01315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUK68_01335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUK68_01340	COG0545	Peptidyl-prolyl cis-trans isomerase
HUK68_01345	COG3604	Transcriptional regulator
HUK68_01365	COG2733	membrane
HUK68_01370	COG4771	TonB-dependent receptor
HUK68_01385	COG1252	NADH dehydrogenase
HUK68_01395	COG2197	response regulator
HUK68_01405	COG0277	FAD linked oxidase domain protein
HUK68_01420	COG2721	sulfolactate sulfo-lyase activity
HUK68_01435	COG0277	FAD linked oxidase domain protein
HUK68_01440	COG0583	DNA-binding transcription factor activity
HUK68_01485	COG1979	alcohol dehydrogenase
HUK68_01490	COG0243	molybdopterin cofactor binding
HUK68_01495	COG1473	amidohydrolase
HUK68_01520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUK68_01575	COG1022	Amp-dependent synthetase and ligase
HUK68_01580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUK68_01585	COG1187	pseudouridine synthase activity
HUK68_01590	COG0326	Molecular chaperone. Has ATPase activity
HUK68_01600	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HUK68_01610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUK68_01615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_01625	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUK68_01635	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HUK68_01640	COG0519	Catalyzes the synthesis of GMP from XMP
HUK68_01645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUK68_01650	COG5001	Diguanylate cyclase
HUK68_01650	COG3300	MHYT domain
HUK68_01655	COG0513	Belongs to the DEAD box helicase family
HUK68_01660	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUK68_01665	COG1490	D-aminoacyl-tRNA deacylase activity
HUK68_01670	COG0730	response to heat
HUK68_01675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUK68_01680	COG1702	phosphate starvation-inducible protein PhoH
HUK68_01685	COG0632	four-way junction helicase activity
HUK68_01690	COG2255	four-way junction helicase activity
HUK68_01700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUK68_01710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUK68_01720	COG1253	flavin adenine dinucleotide binding
HUK68_01750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUK68_01780	COG0037	tRNA processing
HUK68_01820	COG1012	belongs to the aldehyde dehydrogenase family
HUK68_01825	COG0617	tRNA 3'-terminal CCA addition
HUK68_01830	COG1454	alcohol dehydrogenase
HUK68_01840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUK68_01845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUK68_01860	COG0318	PFAM AMP-dependent synthetase and ligase
HUK68_01870	COG3186	Phenylalanine-4-hydroxylase
HUK68_01880	COG1522	sequence-specific DNA binding
HUK68_01895	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUK68_01900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUK68_01925	COG0438	transferase activity, transferring glycosyl groups
HUK68_01945	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUK68_01960	COG4260	virion core protein, lumpy skin disease virus
HUK68_01965	COG0752	glycyl-tRNA synthetase alpha subunit
HUK68_01970	COG0751	glycine-tRNA ligase activity
HUK68_01975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUK68_01980	COG0204	Acyl-transferase
HUK68_01995	COG1652	LysM domain
HUK68_02000	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUK68_02035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUK68_02045	COG0642	Histidine kinase
HUK68_02050	COG1309	transcriptional regulator
HUK68_02065	COG1960	acyl-CoA dehydrogenase activity
HUK68_02075	COG1024	Enoyl-CoA hydratase
HUK68_02075	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUK68_02080	COG0183	Belongs to the thiolase family
HUK68_02090	COG1024	Enoyl-CoA hydratase
HUK68_02100	COG1607	acyl-coa hydrolase
HUK68_02105	COG5265	(ABC) transporter
HUK68_02110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUK68_02115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUK68_02120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUK68_02120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HUK68_02125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HUK68_02130	COG0583	DNA-binding transcription factor activity
HUK68_02140	COG0765	amino acid transport
HUK68_02145	COG0765	amino acid transport
HUK68_02150	COG1126	abc transporter atp-binding protein
HUK68_02155	COG0418	dihydroorotase activity
HUK68_02165	COG0501	Belongs to the peptidase M48B family
HUK68_02170	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HUK68_02175	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HUK68_02185	COG1132	(ABC) transporter
HUK68_02205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUK68_02220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUK68_02230	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HUK68_02235	COG0523	cobalamin synthesis protein
HUK68_02250	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HUK68_02255	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HUK68_02265	COG2001	Belongs to the MraZ family
HUK68_02270	COG0275	rRNA processing
HUK68_02285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUK68_02290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUK68_02295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUK68_02300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUK68_02305	COG0772	Belongs to the SEDS family
HUK68_02310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUK68_02315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUK68_02320	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUK68_02325	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUK68_02340	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HUK68_02360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUK68_02370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUK68_02380	COG0557	exoribonuclease II activity
HUK68_02385	COG3150	esterase
HUK68_02390	COG0772	Belongs to the SEDS family
HUK68_02395	COG0312	modulator of DNA gyrase
HUK68_02400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUK68_02405	COG3098	single-species biofilm formation
HUK68_02415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUK68_02425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUK68_02430	COG0511	ligase activity, forming carbon-carbon bonds
HUK68_02435	COG0439	Biotin carboxylase
HUK68_02440	COG2264	protein methyltransferase activity
HUK68_02450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUK68_02465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUK68_02470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUK68_02470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUK68_02500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUK68_02510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUK68_02520	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUK68_02530	COG2814	Major facilitator Superfamily
HUK68_02535	COG3622	Belongs to the hyi family
HUK68_02560	COG0864	Transcriptional regulator
HUK68_02570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUK68_02575	COG4172	Belongs to the ABC transporter superfamily
HUK68_02585	COG3706	GGDEF domain
HUK68_02640	COG1024	Enoyl-CoA hydratase
HUK68_02655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUK68_02670	COG0012	GTP binding
HUK68_02705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUK68_02705	COG0784	Response regulator, receiver
HUK68_02710	COG0789	Transcriptional regulator
HUK68_02765	COG0789	Transcriptional regulator
HUK68_02855	COG2194	sulfuric ester hydrolase activity
HUK68_02965	COG0154	amidase activity
HUK68_02980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUK68_03005	COG1609	Transcriptional regulator
HUK68_03010	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_03025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUK68_03030	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HUK68_03045	COG2814	Major facilitator Superfamily
HUK68_03055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUK68_03065	COG2203	Gaf domain
HUK68_03065	COG2199	diguanylate cyclase activity
HUK68_03100	COG0154	amidase activity
HUK68_03105	COG2814	Major facilitator Superfamily
HUK68_03110	COG0154	amidase activity
HUK68_03120	COG4608	Belongs to the ABC transporter superfamily
HUK68_03125	COG0444	Belongs to the ABC transporter superfamily
HUK68_03135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUK68_03140	COG2188	Transcriptional regulator
HUK68_03170	COG1238	metal cluster binding
HUK68_03180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUK68_03185	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HUK68_03190	COG0138	bifunctional purine biosynthesis protein purh
HUK68_03200	COG0531	amino acid
HUK68_03220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUK68_03250	COG0840	transmembrane signaling receptor activity
HUK68_03260	COG0415	Belongs to the DNA photolyase family
HUK68_03265	COG1678	Uncharacterized ACR, COG1678
HUK68_03270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUK68_03275	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUK68_03280	COG0540	Belongs to the ATCase OTCase family
HUK68_03285	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUK68_03295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUK68_03300	COG4597	amino acid ABC transporter
HUK68_03305	COG0765	amino acid transport
HUK68_03310	COG1126	abc transporter atp-binding protein
HUK68_03315	COG3842	ATPase activity
HUK68_03320	COG1178	ABC-type Fe3 transport system permease component
HUK68_03345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUK68_03350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUK68_03355	COG0697	spore germination
HUK68_03385	COG0582	viral genome integration into host DNA
HUK68_03510	COG0582	viral genome integration into host DNA
HUK68_03545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUK68_03560	COG1280	lysine exporter protein (LysE YggA)
HUK68_03570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUK68_03575	COG1040	competence protein
HUK68_03580	COG2226	methyltransferase
HUK68_03625	COG0109	protoheme IX farnesyltransferase activity
HUK68_03630	COG1999	signal sequence binding
HUK68_03635	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_03640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUK68_03660	COG0612	Peptidase, M16
HUK68_03665	COG0612	Peptidase, M16
HUK68_03670	COG0742	ribosomal rna small subunit methyltransferase
HUK68_03675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUK68_03700	COG4585	Histidine kinase
HUK68_03705	COG2197	response regulator
HUK68_03720	COG0793	Belongs to the peptidase S41A family
HUK68_03725	COG0588	phosphoglycerate mutase activity
HUK68_03730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUK68_03735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HUK68_03740	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HUK68_03745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUK68_03755	COG0583	DNA-binding transcription factor activity
HUK68_03765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUK68_03780	COG2807	transmembrane transport
HUK68_03810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUK68_03810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUK68_03825	COG0489	protein tyrosine kinase activity
HUK68_03830	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HUK68_03845	COG1704	LemA family
HUK68_03850	COG0501	Belongs to the peptidase M48B family
HUK68_03855	COG1193	negative regulation of DNA recombination
HUK68_03865	COG2003	Belongs to the UPF0758 family
HUK68_03870	COG1047	Peptidyl-prolyl cis-trans
HUK68_03875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUK68_03880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUK68_03910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUK68_03915	COG1758	RNA polymerase activity
HUK68_03920	COG0194	GDP metabolic process
HUK68_03925	COG1561	YicC-like family, N-terminal region
HUK68_03935	COG0631	protein serine/threonine phosphatase activity
HUK68_03940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUK68_03945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUK68_03970	COG2188	Transcriptional regulator
HUK68_03980	COG0066	3-isopropylmalate dehydratase activity
HUK68_03985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUK68_03995	COG0318	PFAM AMP-dependent synthetase and ligase
HUK68_04010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUK68_04015	COG1122	ATPase activity
HUK68_04025	COG1268	BioY protein
HUK68_04030	COG0318	PFAM AMP-dependent synthetase and ligase
HUK68_04035	COG0183	Belongs to the thiolase family
HUK68_04065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_04070	COG1960	acyl-CoA dehydrogenase activity
HUK68_04075	COG0583	DNA-binding transcription factor activity
HUK68_04085	COG4829	muconolactone delta-isomerase
HUK68_04100	COG0583	DNA-binding transcription factor activity
HUK68_04110	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_04135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK68_04145	COG1538	Outer membrane efflux protein
HUK68_04155	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_04170	COG0583	DNA-binding transcription factor activity
HUK68_04175	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_04240	COG4970	Tfp pilus assembly protein FimT
HUK68_04270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUK68_04275	COG0457	Tetratricopeptide repeat
HUK68_04280	COG0726	polysaccharide deacetylase
HUK68_04280	COG1649	PFAM Uncharacterised BCR, COG1649
HUK68_04285	COG1215	transferase activity, transferring glycosyl groups
HUK68_04300	COG1309	transcriptional regulator
HUK68_04330	COG2199	diguanylate cyclase activity
HUK68_04330	COG2200	EAL domain
HUK68_04330	COG2203	Gaf domain
HUK68_04335	COG0154	amidase activity
HUK68_04345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUK68_04375	COG1473	amidohydrolase
HUK68_04385	COG3712	iron ion homeostasis
HUK68_04420	COG2099	Precorrin-6x reductase
HUK68_04435	COG2875	Belongs to the precorrin methyltransferase family
HUK68_04455	COG2819	hydrolase of the alpha beta superfamily
HUK68_04465	COG3712	iron ion homeostasis
HUK68_04470	COG1595	DNA-templated transcription, initiation
HUK68_04495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUK68_04495	COG0045	succinate-CoA ligase (ADP-forming) activity
HUK68_04495	COG1042	CoA-binding domain protein
HUK68_04505	COG0583	DNA-binding transcription factor activity
HUK68_04555	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_04565	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_04570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUK68_04575	COG1715	Restriction endonuclease
HUK68_04580	COG0210	DNA helicase
HUK68_04665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUK68_04670	COG1653	transport
HUK68_04675	COG0395	ABC-type sugar transport system, permease component
HUK68_04680	COG1175	transmembrane transport
HUK68_04685	COG3842	ATPase activity
HUK68_04690	COG0546	phosphoglycolate phosphatase activity
HUK68_04705	COG5377	YqaJ viral recombinase family
HUK68_04725	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUK68_04730	COG0830	nickel cation binding
HUK68_04735	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HUK68_04745	COG0804	urea catabolic process
HUK68_04750	COG0832	Belongs to the urease beta subunit family
HUK68_04760	COG0831	urea catabolic process
HUK68_04765	COG2198	Histidine kinase
HUK68_04765	COG5002	protein histidine kinase activity
HUK68_04765	COG0784	Response regulator, receiver
HUK68_04790	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUK68_04815	COG0829	nickel cation binding
HUK68_04820	COG0590	tRNA wobble adenosine to inosine editing
HUK68_04825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUK68_04830	COG1116	anion transmembrane transporter activity
HUK68_04835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUK68_04845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUK68_04850	COG0280	phosphate acetyltransferase
HUK68_04850	COG0281	malic enzyme
HUK68_04880	COG2186	Transcriptional regulator
HUK68_04940	COG3447	MASE1 domain protein
HUK68_04940	COG5001	Diguanylate cyclase
HUK68_04940	COG5002	protein histidine kinase activity
HUK68_04945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUK68_04955	COG3845	ABC transporter
HUK68_04960	COG4603	Belongs to the binding-protein-dependent transport system permease family
HUK68_04985	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUK68_04990	COG0537	adenosine 5'-monophosphoramidase activity
HUK68_05000	COG0402	S-adenosylhomocysteine deaminase activity
HUK68_05005	COG0717	Belongs to the dCTP deaminase family
HUK68_05020	COG2321	neutral zinc metallopeptidase
HUK68_05025	COG0513	Belongs to the DEAD box helicase family
HUK68_05035	COG2721	sulfolactate sulfo-lyase activity
HUK68_05040	COG1802	Transcriptional regulator
HUK68_05045	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_05050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUK68_05055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUK68_05065	COG1012	belongs to the aldehyde dehydrogenase family
HUK68_05070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUK68_05075	COG1253	flavin adenine dinucleotide binding
HUK68_05080	COG2916	Histone family protein nucleoid-structuring protein H-NS
HUK68_05085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUK68_05095	COG3483	tryptophan 2,3-dioxygenase activity
HUK68_05100	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HUK68_05110	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HUK68_05115	COG1113	amino acid transport
HUK68_05120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUK68_05125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUK68_05135	COG0268	Binds directly to 16S ribosomal RNA
HUK68_05140	COG0728	peptidoglycan biosynthetic process
HUK68_05155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUK68_05160	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUK68_05170	COG0617	tRNA 3'-terminal CCA addition
HUK68_05185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUK68_05185	COG0543	2 iron, 2 sulfur cluster binding
HUK68_05210	COG0583	DNA-binding transcription factor activity
HUK68_05230	COG0840	transmembrane signaling receptor activity
HUK68_05460	COG4695	Portal protein
HUK68_05485	COG0425	Belongs to the sulfur carrier protein TusA family
HUK68_05490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUK68_05495	COG0525	valine-tRNA ligase activity
HUK68_05535	COG0181	hydroxymethylbilane synthase activity
HUK68_05540	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUK68_05545	COG1289	transmembrane transporter activity
HUK68_05575	COG1722	exodeoxyribonuclease VII activity
HUK68_05585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUK68_05590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HUK68_05595	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HUK68_05610	COG2267	carboxylic ester hydrolase activity
HUK68_05625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUK68_05640	COG3279	Response regulator of the LytR AlgR family
HUK68_05645	COG2972	Histidine kinase
HUK68_05655	COG1968	undecaprenyl-diphosphatase activity
HUK68_05665	COG2207	Transcriptional regulator
HUK68_05670	COG2807	transmembrane transport
HUK68_05675	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_05690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUK68_05695	COG0667	Aldo Keto reductase
HUK68_05710	COG0483	inositol monophosphate 1-phosphatase activity
HUK68_05720	COG1045	serine acetyltransferase
HUK68_05735	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUK68_05740	COG0840	transmembrane signaling receptor activity
HUK68_05745	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUK68_05750	COG3028	Belongs to the UPF0307 family
HUK68_05755	COG0312	modulator of DNA gyrase
HUK68_05785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUK68_05790	COG2081	HI0933 family
HUK68_05795	COG1607	acyl-coa hydrolase
HUK68_05805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUK68_05820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUK68_05850	COG0577	efflux transmembrane transporter activity
HUK68_05850	COG1136	(ABC) transporter
HUK68_05855	COG0577	efflux transmembrane transporter activity
HUK68_05855	COG1136	(ABC) transporter
HUK68_05865	COG2951	lytic endotransglycosylase activity
HUK68_05880	COG0714	Associated with various cellular activities
HUK68_05895	COG1511	domain protein
HUK68_05895	COG3264	Mechanosensitive ion channel
HUK68_05915	COG1960	acyl-CoA dehydrogenase activity
HUK68_05935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUK68_05940	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HUK68_05945	COG0372	Belongs to the citrate synthase family
HUK68_05950	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HUK68_05955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUK68_05960	COG1053	succinate dehydrogenase
HUK68_05965	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HUK68_05970	COG2009	succinate dehydrogenase
HUK68_05975	COG2188	Transcriptional regulator
HUK68_05980	COG0039	L-malate dehydrogenase activity
HUK68_05985	COG4106	trans-aconitate 2-methyltransferase activity
HUK68_06010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUK68_06015	COG0348	domain, Protein
HUK68_06020	COG0129	dihydroxy-acid dehydratase activity
HUK68_06030	COG1846	Transcriptional regulator
HUK68_06040	COG1902	pentaerythritol trinitrate reductase activity
HUK68_06050	COG0826	peptidase U32
HUK68_06060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUK68_06070	COG2358	TRAP transporter, solute receptor (TAXI family
HUK68_06075	COG0786	glutamate:sodium symporter activity
HUK68_06090	COG4566	intracellular signal transduction
HUK68_06095	COG4191	Histidine kinase
HUK68_06105	COG3119	arylsulfatase activity
HUK68_06130	COG4566	intracellular signal transduction
HUK68_06165	COG0824	Thioesterase
HUK68_06170	COG0436	Aminotransferase
HUK68_06175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUK68_06180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUK68_06195	COG2918	glutathione biosynthetic process
HUK68_06210	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HUK68_06215	COG1473	amidohydrolase
HUK68_06220	COG1285	pathogenesis
HUK68_06235	COG0564	pseudouridine synthase activity
HUK68_06265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUK68_06270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUK68_06280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUK68_06305	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUK68_06325	COG0215	cysteine-tRNA ligase activity
HUK68_06335	COG0825	malonyl-CoA metabolic process
HUK68_06340	COG0037	tRNA processing
HUK68_06345	COG0527	aspartate kinase activity
HUK68_06355	COG1971	Probably functions as a manganese efflux pump
HUK68_06360	COG5001	Diguanylate cyclase
HUK68_06375	COG1063	alcohol dehydrogenase
HUK68_06385	COG2323	membrane
HUK68_06460	COG1187	pseudouridine synthase activity
HUK68_06470	COG0402	S-adenosylhomocysteine deaminase activity
HUK68_06475	COG2233	PERMEase
HUK68_06480	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUK68_06485	COG0642	Histidine kinase
HUK68_06495	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_06525	COG4251	negative regulation of phosphorylation
HUK68_06525	COG5001	Diguanylate cyclase
HUK68_06525	COG2203	Gaf domain
HUK68_06525	COG3706	GGDEF domain
HUK68_06535	COG3300	MHYT domain
HUK68_06535	COG5001	Diguanylate cyclase
HUK68_06555	COG1397	ADP-ribosylglycohydrolase
HUK68_06585	COG1522	sequence-specific DNA binding
HUK68_06620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUK68_06640	COG0583	DNA-binding transcription factor activity
HUK68_06645	COG2814	Major facilitator Superfamily
HUK68_06655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUK68_06665	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HUK68_06670	COG1562	ergosterol biosynthetic process
HUK68_06675	COG0513	Belongs to the DEAD box helicase family
HUK68_06685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK68_06690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUK68_06700	COG0582	viral genome integration into host DNA
HUK68_06930	COG4695	Portal protein
HUK68_06970	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUK68_06975	COG0740	serine-type endopeptidase activity
HUK68_06980	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUK68_06985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUK68_07060	COG4948	Mandelate Racemase Muconate Lactonizing
HUK68_07070	COG2186	Transcriptional regulator
HUK68_07075	COG0477	Major facilitator Superfamily
HUK68_07095	COG1024	Enoyl-CoA hydratase
HUK68_07135	COG1021	2,3-dihydroxybenzoate-AMP ligase
HUK68_07145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUK68_07180	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_07190	COG1230	cation diffusion facilitator family transporter
HUK68_07200	COG4166	transmembrane transport
HUK68_07205	COG4174	ABC transporter (Permease)
HUK68_07210	COG4239	(ABC) transporter, permease
HUK68_07215	COG4172	Belongs to the ABC transporter superfamily
HUK68_07220	COG0583	DNA-binding transcription factor activity
HUK68_07225	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_07235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUK68_07240	COG0066	3-isopropylmalate dehydratase activity
HUK68_07245	COG3040	lipid binding
HUK68_07250	COG5265	(ABC) transporter
HUK68_07270	COG3040	lipid binding
HUK68_07280	COG2010	Cytochrome c
HUK68_07280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUK68_07290	COG0779	Required for maturation of 30S ribosomal subunits
HUK68_07295	COG0195	Participates in both transcription termination and antitermination
HUK68_07300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUK68_07305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUK68_07310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUK68_07320	COG1024	Enoyl-CoA hydratase
HUK68_07325	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUK68_07330	COG2867	negative regulation of translational initiation
HUK68_07350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUK68_07350	COG0519	Catalyzes the synthesis of GMP from XMP
HUK68_07355	COG0612	Peptidase, M16
HUK68_07360	COG1045	serine acetyltransferase
HUK68_07370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_07385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUK68_07390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_07395	COG0583	DNA-binding transcription factor activity
HUK68_07415	COG0583	DNA-binding transcription factor activity
HUK68_07430	COG0137	argininosuccinate synthase activity
HUK68_07435	COG3123	guanosine phosphorylase activity
HUK68_07445	COG1393	Belongs to the ArsC family
HUK68_07450	COG0285	dihydrofolate synthase activity
HUK68_07460	COG1286	toxin biosynthetic process
HUK68_07475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUK68_07530	COG1850	ribulose-bisphosphate carboxylase activity
HUK68_07540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUK68_07545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUK68_07550	COG1609	Transcriptional regulator
HUK68_07565	COG1840	ABC-type Fe3 transport system, periplasmic component
HUK68_07575	COG0824	Thioesterase
HUK68_07580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUK68_07590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUK68_07605	COG1611	Belongs to the LOG family
HUK68_07615	COG2212	antiporter activity
HUK68_07620	COG1863	multisubunit Na H antiporter MnhE subunit
HUK68_07625	COG0651	ATP synthesis coupled electron transport
HUK68_07630	COG1006	Multisubunit Na H antiporter MnhC subunit
HUK68_07635	COG2111	Na H antiporter
HUK68_07635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUK68_07645	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HUK68_07655	COG0776	regulation of translation
HUK68_07665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUK68_07675	COG1605	Chorismate mutase
HUK68_07675	COG0077	Prephenate dehydratase
HUK68_07680	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUK68_07695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUK68_07735	COG1116	anion transmembrane transporter activity
HUK68_07740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUK68_07750	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_07775	COG2199	diguanylate cyclase activity
HUK68_07775	COG2203	Gaf domain
HUK68_07785	COG0784	Response regulator, receiver
HUK68_07785	COG2205	protein histidine kinase activity
HUK68_07790	COG2205	protein histidine kinase activity
HUK68_07805	COG1366	Belongs to the anti-sigma-factor antagonist family
HUK68_07810	COG1366	Belongs to the anti-sigma-factor antagonist family
HUK68_07860	COG0243	molybdopterin cofactor binding
HUK68_07865	COG2146	nitrite reductase [NAD(P)H] activity
HUK68_07870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUK68_07885	COG0405	Gamma-glutamyltransferase
HUK68_07900	COG1116	anion transmembrane transporter activity
HUK68_07905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUK68_07910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUK68_07915	COG3707	response regulator
HUK68_07925	COG1396	sequence-specific DNA binding
HUK68_07940	COG4993	Dehydrogenase
HUK68_07945	COG0783	Belongs to the Dps family
HUK68_07955	COG3042	response to heat
HUK68_07960	COG0720	synthase
HUK68_07965	COG0602	queuosine metabolic process
HUK68_07995	COG1304	FMN binding
HUK68_08005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUK68_08010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUK68_08015	COG0583	DNA-binding transcription factor activity
HUK68_08025	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUK68_08040	COG1335	isochorismatase
HUK68_08050	COG0583	DNA-binding transcription factor activity
HUK68_08060	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HUK68_08065	COG0308	aminopeptidase N
HUK68_08090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUK68_08105	COG2022	thiamine diphosphate biosynthetic process
HUK68_08125	COG4303	Ethanolamine ammonia lyase large subunit
HUK68_08130	COG4302	ethanolamine ammonia-lyase activity
HUK68_08135	COG0351	phosphomethylpyrimidine kinase
HUK68_08155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUK68_08165	COG2917	probably involved in intracellular septation
HUK68_08170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUK68_08175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUK68_08180	COG0318	PFAM AMP-dependent synthetase and ligase
HUK68_08190	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUK68_08200	COG0411	ABC transporter
HUK68_08210	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUK68_08210	COG1024	Enoyl-CoA hydratase
HUK68_08215	COG0183	Belongs to the thiolase family
HUK68_08220	COG1960	acyl-CoA dehydrogenase activity
HUK68_08230	COG0642	Histidine kinase
HUK68_08240	COG3639	organic phosphonate transmembrane transporter activity
HUK68_08245	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HUK68_08250	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HUK68_08280	COG2814	Major facilitator Superfamily
HUK68_08295	COG2130	NADP-dependent
HUK68_08310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUK68_08315	COG1538	Outer membrane efflux protein
HUK68_08340	COG2183	response to ionizing radiation
HUK68_08370	COG2197	response regulator
HUK68_08380	COG0628	permease
HUK68_08395	COG0657	acetylesterase activity
HUK68_08405	COG0354	folic acid binding
HUK68_08410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUK68_08415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUK68_08420	COG0470	DNA polymerase III
HUK68_08430	COG0084	hydrolase, TatD family'
HUK68_08455	COG0579	oxidoreductase
HUK68_08460	COG1301	dicarboxylic acid transport
HUK68_08475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HUK68_08485	COG2885	chlorophyll binding
HUK68_08490	COG0823	Involved in the tonB-independent uptake of proteins
HUK68_08495	COG1132	(ABC) transporter
HUK68_08510	COG3276	selenocysteine insertion sequence binding
HUK68_08525	COG2864	formate dehydrogenase
HUK68_08530	COG0437	4 iron, 4 sulfur cluster binding
HUK68_08540	COG0628	permease
HUK68_08545	COG0567	Dehydrogenase, E1 component
HUK68_08550	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUK68_08555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUK68_08560	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HUK68_08580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUK68_08590	COG0563	adenylate kinase activity
HUK68_08600	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HUK68_08605	COG2835	tetraacyldisaccharide 4'-kinase activity
HUK68_08610	COG1663	tetraacyldisaccharide 4'-kinase activity
HUK68_08620	COG0811	peptide transport
HUK68_08625	COG1570	exodeoxyribonuclease VII activity
HUK68_08630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUK68_08660	COG0243	molybdopterin cofactor binding
HUK68_08670	COG1473	amidohydrolase
HUK68_08710	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HUK68_08745	COG1960	acyl-CoA dehydrogenase activity
HUK68_08780	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HUK68_08785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUK68_08790	COG0667	Aldo Keto reductase
HUK68_08805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUK68_08810	COG1739	Uncharacterized protein family UPF0029
HUK68_08825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_08830	COG1414	Transcriptional regulator
HUK68_08840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUK68_08845	COG0183	Belongs to the thiolase family
HUK68_08850	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_08865	COG0556	nucleotide-excision repair
HUK68_08870	COG1959	2 iron, 2 sulfur cluster binding
HUK68_08875	COG1104	cysteine desulfurase activity
HUK68_08880	COG0822	iron-sulfur transferase activity
HUK68_08885	COG0316	Belongs to the HesB IscA family
HUK68_08895	COG0443	Heat shock 70 kDa protein
HUK68_08900	COG0633	Ferredoxin
HUK68_08960	COG1960	acyl-CoA dehydrogenase activity
HUK68_08970	COG0183	Belongs to the thiolase family
HUK68_08975	COG0318	PFAM AMP-dependent synthetase and ligase
HUK68_08980	COG4608	Belongs to the ABC transporter superfamily
HUK68_08985	COG0444	Belongs to the ABC transporter superfamily
HUK68_08990	COG0747	negative chemotaxis
HUK68_08995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUK68_09035	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_09040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_09045	COG1960	acyl-CoA dehydrogenase activity
HUK68_09050	COG1960	acyl-CoA dehydrogenase activity
HUK68_09070	COG0579	oxidoreductase
HUK68_09090	COG0167	dihydroorotate dehydrogenase activity
HUK68_09095	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HUK68_09115	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUK68_09120	COG4566	intracellular signal transduction
HUK68_09130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUK68_09135	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUK68_09140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUK68_09170	COG0791	NLP P60 protein
HUK68_09195	COG1054	Belongs to the UPF0176 family
HUK68_09215	COG1309	transcriptional regulator
HUK68_09250	COG0259	pyridoxamine-phosphate oxidase activity
HUK68_09255	COG0346	lactoylglutathione lyase activity
HUK68_09275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUK68_09295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUK68_09300	COG1116	anion transmembrane transporter activity
HUK68_09320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUK68_09355	COG1846	Transcriptional regulator
HUK68_09360	COG1764	response to oxidative stress
HUK68_09365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUK68_09410	COG4770	biotin carboxylase activity
HUK68_09415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUK68_09420	COG1703	isobutyryl-CoA mutase activity
HUK68_09425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUK68_09425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUK68_09430	COG1802	Transcriptional regulator
HUK68_09440	COG0583	DNA-binding transcription factor activity
HUK68_09455	COG2072	flavoprotein involved in K transport
HUK68_09460	COG0601	transmembrane transport
HUK68_09465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUK68_09470	COG0444	Belongs to the ABC transporter superfamily
HUK68_09475	COG4608	Belongs to the ABC transporter superfamily
HUK68_09480	COG0747	negative chemotaxis
HUK68_09500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUK68_09510	COG2878	Part of a membrane complex involved in electron transport
HUK68_09515	COG0436	Aminotransferase
HUK68_09520	COG2171	N-acyltransferase activity
HUK68_09530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUK68_09535	COG2890	protein-(glutamine-N5) methyltransferase activity
HUK68_09540	COG0488	(ABC) transporter
HUK68_09545	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_09550	COG0183	Belongs to the thiolase family
HUK68_09555	COG3243	poly(R)-hydroxyalkanoic acid synthase
HUK68_09580	COG2816	NAD+ diphosphatase activity
HUK68_09600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUK68_09610	COG1196	nuclear chromosome segregation
HUK68_09615	COG1742	UPF0060 membrane protein
HUK68_09625	COG4181	ATPase activity
HUK68_09645	COG0626	cystathionine gamma-synthase activity
HUK68_09655	COG0659	secondary active sulfate transmembrane transporter activity
HUK68_09670	COG1054	Belongs to the UPF0176 family
HUK68_09675	COG2259	Doxx family
HUK68_09680	COG0583	DNA-binding transcription factor activity
HUK68_09685	COG1233	COG1233 Phytoene dehydrogenase and related
HUK68_09690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUK68_09695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUK68_09700	COG1902	pentaerythritol trinitrate reductase activity
HUK68_09710	COG2610	gluconate transmembrane transporter activity
HUK68_09715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUK68_09720	COG0477	Major facilitator Superfamily
HUK68_09730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUK68_09735	COG1845	cytochrome c oxidase, subunit III
HUK68_09740	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HUK68_09755	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HUK68_09760	COG0109	protoheme IX farnesyltransferase activity
HUK68_09765	COG1612	heme a metabolic process
HUK68_09780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUK68_09795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUK68_09805	COG0795	lipopolysaccharide-transporting ATPase activity
HUK68_09815	COG0583	DNA-binding transcription factor activity
HUK68_09820	COG0436	Aminotransferase
HUK68_09840	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HUK68_09855	COG0424	maF-like protein
HUK68_09860	COG1115	amino acid carrier protein
HUK68_09865	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HUK68_09870	COG0799	negative regulation of ribosome biogenesis
HUK68_09875	COG0408	coproporphyrinogen oxidase activity
HUK68_09880	COG0151	Belongs to the GarS family
HUK68_09885	COG0217	transcriptional regulatory protein
HUK68_09890	COG0433	COG0433 Predicted ATPase
HUK68_09910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUK68_09915	COG0217	transcriptional regulatory protein
HUK68_09920	COG2133	pyrroloquinoline quinone binding
HUK68_09925	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HUK68_09935	COG0700	Nucleoside recognition
HUK68_09940	COG2925	Exonuclease
HUK68_09945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUK68_09950	COG0542	response to heat
HUK68_09955	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUK68_09970	COG1199	ATP-dependent helicase activity
HUK68_10000	COG5002	protein histidine kinase activity
HUK68_10010	COG0800	Aldolase
HUK68_10025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUK68_10030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUK68_10035	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HUK68_10040	COG3265	gluconokinase activity
HUK68_10045	COG1609	Transcriptional regulator
HUK68_10055	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUK68_10065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK68_10085	COG0431	NADPH-dependent FMN reductase
HUK68_10100	COG0798	PFAM Bile acid sodium symporter
HUK68_10110	COG0640	Transcriptional regulator
HUK68_10160	COG0629	single-stranded DNA binding
HUK68_10165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUK68_10315	COG2003	Belongs to the UPF0758 family
HUK68_10370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUK68_10370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUK68_10375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUK68_10380	COG1252	NADH dehydrogenase
HUK68_10385	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HUK68_10440	COG0583	DNA-binding transcription factor activity
HUK68_10450	COG0583	DNA-binding transcription factor activity
HUK68_10465	COG2837	iron assimilation
HUK68_10470	COG0582	viral genome integration into host DNA
HUK68_10475	COG0564	pseudouridine synthase activity
HUK68_10480	COG2982	Protein involved in outer membrane biogenesis
HUK68_10485	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUK68_10500	COG4566	intracellular signal transduction
HUK68_10505	COG0753	catalase activity
HUK68_10530	COG4120	Belongs to the binding-protein-dependent transport system permease family
HUK68_10540	COG0833	amino acid
HUK68_10555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUK68_10565	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUK68_10565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUK68_10575	COG0564	pseudouridine synthase activity
HUK68_10600	COG0410	ABC transporter
HUK68_10605	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_10615	COG0583	DNA-binding transcription factor activity
HUK68_10620	COG2814	Major facilitator Superfamily
HUK68_10625	COG0583	DNA-binding transcription factor activity
HUK68_10630	COG1741	Belongs to the pirin family
HUK68_10635	COG1335	isochorismatase
HUK68_10705	COG4774	siderophore transport
HUK68_10720	COG0583	DNA-binding transcription factor activity
HUK68_10725	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUK68_10735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_10740	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUK68_10755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUK68_10825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUK68_10835	COG2153	protein acetylation
HUK68_10850	COG2951	lytic endotransglycosylase activity
HUK68_10855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HUK68_10855	COG0678	peroxiredoxin activity
HUK68_10860	COG0514	ATP-dependent DNA helicase (RecQ)
HUK68_10870	COG3119	arylsulfatase activity
HUK68_10880	COG0583	DNA-binding transcription factor activity
HUK68_10890	COG0589	response to stress
HUK68_10900	COG4948	Mandelate Racemase Muconate Lactonizing
HUK68_10930	COG2814	Major facilitator Superfamily
HUK68_10940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUK68_10945	COG1414	Transcriptional regulator
HUK68_10965	COG0667	Aldo Keto reductase
HUK68_10995	COG2159	amidohydrolase
HUK68_11005	COG2828	Protein conserved in bacteria
HUK68_11010	COG0583	DNA-binding transcription factor activity
HUK68_11040	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_11045	COG0318	PFAM AMP-dependent synthetase and ligase
HUK68_11050	COG0748	coenzyme F420 binding
HUK68_11060	COG1643	Atp-dependent helicase
HUK68_11065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUK68_11065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUK68_11090	COG1187	pseudouridine synthase activity
HUK68_11095	COG0583	DNA-binding transcription factor activity
HUK68_11110	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HUK68_11115	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HUK68_11120	COG2860	membrane
HUK68_11125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUK68_11125	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HUK68_11140	COG0175	sulfate reduction
HUK68_11155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HUK68_11160	COG0492	ferredoxin-NADP+ reductase activity
HUK68_11170	COG0688	phosphatidylethanolamine metabolic process
HUK68_11175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUK68_11225	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HUK68_11230	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUK68_11235	COG4208	sulfate ABC transporter
HUK68_11245	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HUK68_11260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUK68_11270	COG4772	TonB-dependent receptor
HUK68_11280	COG1464	Belongs to the NlpA lipoprotein family
HUK68_11285	COG2011	ABC-type metal ion transport system permease component
HUK68_11290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUK68_11295	COG1464	Belongs to the NlpA lipoprotein family
HUK68_11315	COG0776	regulation of translation
HUK68_11320	COG0072	phenylalanine-tRNA ligase activity
HUK68_11320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUK68_11325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUK68_11330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUK68_11335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUK68_11340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUK68_11345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUK68_11350	COG4770	biotin carboxylase activity
HUK68_11355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUK68_11360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUK68_11365	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUK68_11420	COG2274	protein secretion by the type I secretion system
HUK68_11425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK68_11450	COG4964	Belongs to the GSP D family
HUK68_11505	COG2204	response regulator
HUK68_11530	COG2032	superoxide dismutase activity
HUK68_11545	COG2391	methyltransferase activity
HUK68_11555	COG0737	Belongs to the 5'-nucleotidase family
HUK68_11560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUK68_11565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUK68_11565	COG2010	Cytochrome c
HUK68_11590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUK68_11605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUK68_11610	COG0322	excinuclease ABC activity
HUK68_11620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUK68_11635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUK68_11640	COG1686	Belongs to the peptidase S11 family
HUK68_11650	COG4774	siderophore transport
HUK68_11655	COG3128	pkhd-type hydroxylase
HUK68_11690	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HUK68_11695	COG0670	Belongs to the BI1 family
HUK68_11705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUK68_11710	COG3191	aminopeptidase activity
HUK68_11715	COG0488	(ABC) transporter
HUK68_11720	COG0513	Belongs to the DEAD box helicase family
HUK68_11730	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUK68_11740	COG0583	DNA-binding transcription factor activity
HUK68_11750	COG1446	asparaginase
HUK68_11755	COG2011	ABC-type metal ion transport system permease component
HUK68_11760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUK68_11765	COG4948	Mandelate Racemase Muconate Lactonizing
HUK68_11770	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_11775	COG1609	Transcriptional regulator
HUK68_11785	COG4948	Mandelate Racemase Muconate Lactonizing
HUK68_11795	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HUK68_11800	COG1309	transcriptional regulator
HUK68_11805	COG4993	Dehydrogenase
HUK68_11810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUK68_11815	COG2719	SpoVR family
HUK68_11825	COG2766	serine protein kinase
HUK68_11830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUK68_11835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HUK68_11840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUK68_11845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUK68_11855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUK68_11865	COG2205	protein histidine kinase activity
HUK68_11955	COG2197	response regulator
HUK68_11960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK68_12000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUK68_12005	COG0596	Alpha beta hydrolase
HUK68_12010	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_12030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUK68_12030	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUK68_12035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUK68_12035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUK68_12040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUK68_12045	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_12050	COG0560	Phosphoserine phosphatase
HUK68_12060	COG3530	Putative quorum-sensing-regulated virulence factor
HUK68_12065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUK68_12070	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUK68_12075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUK68_12100	COG0583	DNA-binding transcription factor activity
HUK68_12115	COG2900	Belongs to the SlyX family
HUK68_12120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUK68_12125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUK68_12130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_12135	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_12140	COG1960	acyl-CoA dehydrogenase activity
HUK68_12145	COG0583	DNA-binding transcription factor activity
HUK68_12150	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUK68_12165	COG1492	cobalamin metabolic process
HUK68_12175	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUK68_12180	COG0778	Nitroreductase
HUK68_12185	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HUK68_12190	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUK68_12195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUK68_12210	COG1797	cobyrinic acid a,c-diamide synthase activity
HUK68_12235	COG3237	CsbD-like
HUK68_12240	COG3300	MHYT domain
HUK68_12240	COG5001	Diguanylate cyclase
HUK68_12255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUK68_12260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUK68_12290	COG3278	Belongs to the heme-copper respiratory oxidase family
HUK68_12300	COG2217	Heavy metal translocating P-type atpase
HUK68_12310	COG0318	PFAM AMP-dependent synthetase and ligase
HUK68_12330	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUK68_12345	COG4654	Cytochrome c, class I
HUK68_12355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUK68_12365	COG4175	Glycine betaine
HUK68_12370	COG4176	ABC-type proline glycine betaine transport system permease component
HUK68_12375	COG2113	Glycine betaine
HUK68_12390	COG0114	fumarate hydratase activity
HUK68_12400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUK68_12405	COG1451	nucleotide metabolic process
HUK68_12415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUK68_12420	COG1666	GTP binding
HUK68_12425	COG3577	Aspartyl protease
HUK68_12435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUK68_12440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUK68_12445	COG0667	Aldo Keto reductase
HUK68_12465	COG1414	Transcriptional regulator
HUK68_12495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK68_12520	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUK68_12530	COG4771	TonB-dependent receptor
HUK68_12540	COG0765	amino acid transport
HUK68_12545	COG3842	ATPase activity
HUK68_12550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUK68_12555	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUK68_12560	COG2239	Acts as a magnesium transporter
HUK68_12580	COG1538	Outer membrane efflux protein
HUK68_12585	COG3047	cAMP biosynthetic process
HUK68_12590	COG2354	Protein conserved in bacteria
HUK68_12595	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUK68_12600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUK68_12605	COG4558	Periplasmic binding protein
HUK68_12610	COG3720	iron ion transport
HUK68_12620	COG4771	TonB-dependent receptor
HUK68_12625	COG2986	histidine ammonia-lyase
HUK68_12630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HUK68_12635	COG1228	amidohydrolase
HUK68_12660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUK68_12660	COG0047	phosphoribosylformylglycinamidine synthase activity
HUK68_12675	COG0242	peptide deformylase activity
HUK68_12710	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HUK68_12715	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HUK68_12720	COG1414	Transcriptional regulator
HUK68_12730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUK68_12735	COG1183	phosphatidylcholine synthase activity
HUK68_12740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUK68_12745	COG0440	acetolactate synthase activity
HUK68_12750	COG0028	Belongs to the TPP enzyme family
HUK68_12755	COG1595	DNA-templated transcription, initiation
HUK68_12775	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HUK68_12785	COG0347	Belongs to the P(II) protein family
HUK68_12800	COG2610	gluconate transmembrane transporter activity
HUK68_12805	COG0840	transmembrane signaling receptor activity
HUK68_12810	COG0835	chemotaxis
HUK68_12815	COG0840	transmembrane signaling receptor activity
HUK68_12820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUK68_12835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUK68_12840	COG0746	molybdenum cofactor guanylyltransferase activity
HUK68_12850	COG3706	GGDEF domain
HUK68_12860	COG0328	RNA-DNA hybrid ribonuclease activity
HUK68_12865	COG2226	methyltransferase
HUK68_12870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUK68_12875	COG0741	lytic transglycosylase activity
HUK68_12875	COG1388	LysM domain
HUK68_12885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUK68_12890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUK68_12895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUK68_12900	COG0840	transmembrane signaling receptor activity
HUK68_12915	COG3118	belongs to the thioredoxin family
HUK68_12920	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUK68_12925	COG0254	rRNA binding
HUK68_12940	COG0534	Mate efflux family protein
HUK68_12950	COG0745	RESPONSE REGULATOR receiver
HUK68_12955	COG0704	Plays a role in the regulation of phosphate uptake
HUK68_12960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUK68_12965	COG0581	inorganic phosphate transmembrane transporter activity
HUK68_12970	COG0573	inorganic phosphate transmembrane transporter activity
HUK68_12975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUK68_12995	COG0248	Ppx GppA phosphatase
HUK68_13005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUK68_13015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUK68_13020	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HUK68_13025	COG1534	Rna-binding protein
HUK68_13040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUK68_13045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUK68_13050	COG0505	Belongs to the CarA family
HUK68_13055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUK68_13060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUK68_13065	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUK68_13070	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUK68_13075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUK68_13080	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUK68_13095	COG0750	zinc metalloprotease
HUK68_13100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUK68_13105	COG0575	Belongs to the CDS family
HUK68_13110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUK68_13115	COG0233	cytoplasmic translational termination
HUK68_13120	COG0528	UMP kinase activity
HUK68_13125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUK68_13130	COG0052	Belongs to the universal ribosomal protein uS2 family
HUK68_13140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUK68_13145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUK68_13145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUK68_13150	COG0557	exoribonuclease II activity
HUK68_13195	COG0741	lytic transglycosylase activity
HUK68_13200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUK68_13205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUK68_13215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUK68_13230	COG2267	carboxylic ester hydrolase activity
HUK68_13240	COG1295	ribonuclease BN
HUK68_13275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUK68_13280	COG4597	amino acid ABC transporter
HUK68_13285	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HUK68_13295	COG2194	sulfuric ester hydrolase activity
HUK68_13310	COG0028	Belongs to the TPP enzyme family
HUK68_13320	COG1408	metallophosphoesterase
HUK68_13325	COG2207	Transcriptional regulator
HUK68_13325	COG3708	Transcriptional regulator
HUK68_13335	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_13345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUK68_13385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUK68_13390	COG0022	dehydrogenase e1 component
HUK68_13400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUK68_13435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUK68_13435	COG1116	anion transmembrane transporter activity
HUK68_13440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUK68_13450	COG1960	acyl-CoA dehydrogenase activity
HUK68_13455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUK68_13470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUK68_13495	COG0431	NADPH-dependent FMN reductase
HUK68_13505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUK68_13520	COG3300	MHYT domain
HUK68_13520	COG5001	Diguanylate cyclase
HUK68_13545	COG0708	Exodeoxyribonuclease III
HUK68_13560	COG3852	Histidine kinase
HUK68_13570	COG0174	glutamine synthetase
HUK68_13600	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HUK68_13605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUK68_13610	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HUK68_13615	COG0330	HflC and HflK could
HUK68_13620	COG0330	HflC and HflK could
HUK68_13625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUK68_13630	COG1923	regulation of RNA biosynthetic process
HUK68_13635	COG1160	GTP binding
HUK68_13640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUK68_13650	COG0124	histidyl-tRNA synthetase
HUK68_13655	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUK68_13670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUK68_13675	COG0105	UTP biosynthetic process
HUK68_13680	COG1187	pseudouridine synthase activity
HUK68_13685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUK68_13690	COG0564	pseudouridine synthase activity
HUK68_13700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUK68_13705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HUK68_13710	COG3321	synthase
HUK68_13710	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_13710	COG0604	alcohol dehydrogenase
HUK68_13715	COG0786	glutamate:sodium symporter activity
HUK68_13720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUK68_13745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUK68_13790	COG0402	S-adenosylhomocysteine deaminase activity
HUK68_13795	COG0251	oxidation-reduction process
HUK68_13815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUK68_13830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_13840	COG0583	DNA-binding transcription factor activity
HUK68_13860	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HUK68_13880	COG4628	conserved protein (DUF2132)
HUK68_13890	COG2308	Evidence 4 Homologs of previously reported genes of
HUK68_13910	COG0741	lytic transglycosylase activity
HUK68_13935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUK68_13940	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HUK68_13950	COG2850	peptidyl-arginine hydroxylation
HUK68_13985	COG1012	belongs to the aldehyde dehydrogenase family
HUK68_13990	COG1047	Peptidyl-prolyl cis-trans
HUK68_14010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUK68_14015	COG0504	CTP synthase activity
HUK68_14020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HUK68_14030	COG0148	phosphopyruvate hydratase activity
HUK68_14035	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HUK68_14055	COG2833	Protein of unknown function (DUF455)
HUK68_14060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HUK68_14065	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HUK68_14075	COG4974	Belongs to the 'phage' integrase family
HUK68_14080	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_14085	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUK68_14090	COG0802	atpase or kinase
HUK68_14095	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUK68_14105	COG0586	Pfam SNARE associated Golgi protein
HUK68_14115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUK68_14120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUK68_14130	COG2267	carboxylic ester hydrolase activity
HUK68_14140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUK68_14145	COG1136	(ABC) transporter
HUK68_14180	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUK68_14210	COG1007	ATP synthesis coupled electron transport
HUK68_14225	COG0713	ATP synthesis coupled electron transport
HUK68_14235	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUK68_14240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUK68_14245	COG1034	ATP synthesis coupled electron transport
HUK68_14260	COG0649	NAD binding
HUK68_14265	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUK68_14270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUK68_14275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUK68_14290	COG0149	triose-phosphate isomerase activity
HUK68_14295	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_14295	COG3321	synthase
HUK68_14295	COG0604	alcohol dehydrogenase
HUK68_14300	COG1185	polyribonucleotide nucleotidyltransferase activity
HUK68_14305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUK68_14315	COG4970	Tfp pilus assembly protein FimT
HUK68_14345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUK68_14345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUK68_14355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUK68_14360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUK68_14370	COG2264	protein methyltransferase activity
HUK68_14390	COG0542	response to heat
HUK68_14395	COG0314	molybdopterin synthase activity
HUK68_14420	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HUK68_14425	COG0303	'Molybdopterin
HUK68_14430	COG1763	Mo-molybdopterin cofactor biosynthetic process
HUK68_14445	COG0436	Aminotransferase
HUK68_14455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUK68_14460	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUK68_14480	COG0305	Participates in initiation and elongation during chromosome replication
HUK68_14485	COG0359	binds to the 23S rRNA
HUK68_14490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUK68_14495	COG2965	DNA replication, synthesis of RNA primer
HUK68_14500	COG0360	Binds together with S18 to 16S ribosomal RNA
HUK68_14505	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUK68_14510	COG0443	Heat shock 70 kDa protein
HUK68_14515	COG0484	heat shock protein binding
HUK68_14525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUK68_14530	COG0066	3-isopropylmalate dehydratase activity
HUK68_14535	COG0473	3-isopropylmalate dehydrogenase activity
HUK68_14560	COG0101	tRNA pseudouridine synthase activity
HUK68_14565	COG0135	phosphoribosylanthranilate isomerase activity
HUK68_14570	COG0133	tryptophan synthase activity
HUK68_14575	COG0159	tryptophan synthase activity
HUK68_14580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUK68_14585	COG0762	integral membrane protein
HUK68_14595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUK68_14600	COG0745	RESPONSE REGULATOR receiver
HUK68_14620	COG1472	Belongs to the glycosyl hydrolase 3 family
HUK68_14625	COG0736	holo-[acyl-carrier-protein] synthase activity
HUK68_14630	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HUK68_14635	COG1381	Involved in DNA repair and RecF pathway recombination
HUK68_14640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUK68_14645	COG0571	ribonuclease III activity
HUK68_14655	COG0681	Belongs to the peptidase S26 family
HUK68_14660	COG0481	GTPase activity
HUK68_14665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUK68_14670	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HUK68_14685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUK68_14690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUK68_14700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUK68_14705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUK68_14710	COG0416	fatty acid biosynthetic process
HUK68_14715	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUK68_14720	COG1399	metal-binding, possibly nucleic acid-binding protein
HUK68_14725	COG0424	maF-like protein
HUK68_14730	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUK68_14755	COG0616	signal peptide processing
HUK68_14755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUK68_14765	COG0564	pseudouridine synthase activity
HUK68_14770	COG1530	ribonuclease E activity
HUK68_14775	COG3022	response to hydroperoxide
HUK68_14785	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HUK68_14785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HUK68_14790	COG0840	transmembrane signaling receptor activity
HUK68_14795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUK68_14805	COG1304	FMN binding
HUK68_14810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUK68_14820	COG0395	ABC-type sugar transport system, permease component
HUK68_14835	COG3842	ATPase activity
HUK68_14850	COG0165	Argininosuccinate lyase
HUK68_14855	COG2972	Histidine kinase
HUK68_14855	COG0745	RESPONSE REGULATOR receiver
HUK68_14880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HUK68_14900	COG0210	DNA helicase
HUK68_14905	COG0516	GMP reductase activity
HUK68_14910	COG2084	Dehydrogenase
HUK68_14940	COG2814	Major facilitator Superfamily
HUK68_14945	COG0513	Belongs to the DEAD box helicase family
HUK68_14950	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUK68_14955	COG0501	Belongs to the peptidase M48B family
HUK68_14960	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUK68_14965	COG1162	GTPase activity
HUK68_14970	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUK68_14980	COG0335	large ribosomal subunit rRNA binding
HUK68_14985	COG0336	Belongs to the RNA methyltransferase TrmD family
HUK68_14990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUK68_14995	COG0228	four-way junction DNA binding
HUK68_15010	COG0306	phosphate transporter
HUK68_15015	COG1392	Phosphate transport regulator
HUK68_15020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUK68_15030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HUK68_15035	COG1674	ftsk spoiiie
HUK68_15040	COG0492	ferredoxin-NADP+ reductase activity
HUK68_15045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUK68_15050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUK68_15055	COG1404	Belongs to the peptidase S8 family
HUK68_15065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUK68_15065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUK68_15075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUK68_15080	COG3132	Protein of unknown function, DUF480
HUK68_15085	COG1960	acyl-CoA dehydrogenase activity
HUK68_15090	COG1960	acyl-CoA dehydrogenase activity
HUK68_15095	COG3781	membrane
HUK68_15100	COG3647	Membrane
HUK68_15120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUK68_15135	COG0196	riboflavin kinase activity
HUK68_15140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUK68_15145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUK68_15150	COG1283	sodium-dependent phosphate transmembrane transporter activity
HUK68_15165	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_15185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUK68_15205	COG0084	hydrolase, TatD family'
HUK68_15210	COG1136	(ABC) transporter
HUK68_15215	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUK68_15230	COG0613	PHP domain protein
HUK68_15235	COG0009	L-threonylcarbamoyladenylate synthase
HUK68_15245	COG1994	Peptidase M50
HUK68_15250	COG0180	Tryptophanyl-tRNA synthetase
HUK68_15290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUK68_15295	COG1121	(ABC) transporter
HUK68_15360	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUK68_15370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUK68_15375	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_15380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUK68_15390	COG1420	regulation of RNA biosynthetic process
HUK68_15395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUK68_15400	COG0497	DNA recombination
HUK68_15405	COG1660	Displays ATPase and GTPase activities
HUK68_15410	COG1194	a g-specific adenine glycosylase
HUK68_15415	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HUK68_15420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUK68_15430	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HUK68_15435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUK68_15445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUK68_15450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUK68_15455	COG0193	aminoacyl-tRNA hydrolase activity
HUK68_15460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUK68_15470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUK68_15480	COG4608	Belongs to the ABC transporter superfamily
HUK68_15485	COG0747	negative chemotaxis
HUK68_15490	COG1280	lysine exporter protein (LysE YggA)
HUK68_15500	COG0302	gtp cyclohydrolase
HUK68_15505	COG3568	Endonuclease Exonuclease Phosphatase
HUK68_15515	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUK68_15535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUK68_15550	COG2226	methyltransferase
HUK68_15570	COG1653	transport
HUK68_15575	COG1175	transmembrane transport
HUK68_15580	COG0395	ABC-type sugar transport system, permease component
HUK68_15585	COG3842	ATPase activity
HUK68_15590	COG0584	glycerophosphoryl diester phosphodiesterase
HUK68_15615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUK68_15620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUK68_15630	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HUK68_15635	COG1253	flavin adenine dinucleotide binding
HUK68_15640	COG0741	lytic transglycosylase activity
HUK68_15645	COG0442	prolyl-tRNA aminoacylation
HUK68_15650	COG0494	nUDIX hydrolase
HUK68_15655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUK68_15660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUK68_15665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUK68_15670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUK68_15675	COG0142	geranyltranstransferase activity
HUK68_15685	COG0640	Transcriptional regulator
HUK68_15710	COG1522	sequence-specific DNA binding
HUK68_15730	COG0237	dephospho-CoA kinase activity
HUK68_15735	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HUK68_15740	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HUK68_15745	COG0494	nUDIX hydrolase
HUK68_15755	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUK68_15760	COG0653	protein targeting
HUK68_15775	COG2969	positive regulation of protein catabolic process
HUK68_15780	COG0625	glutathione transferase activity
HUK68_15785	COG2857	Cytochrome c1
HUK68_15790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUK68_15795	COG0723	plastoquinol--plastocyanin reductase activity
HUK68_15800	COG1970	mechanosensitive ion channel activity
HUK68_15805	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HUK68_15810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUK68_15825	COG0805	protein transport
HUK68_15830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUK68_15835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUK68_15840	COG0537	adenosine 5'-monophosphoramidase activity
HUK68_15850	COG0140	phosphoribosyl-ATP diphosphatase activity
HUK68_15855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUK68_15860	COG0107	imidazoleglycerol-phosphate synthase activity
HUK68_15865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUK68_15875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUK68_15885	COG0131	Imidazoleglycerol-phosphate dehydratase
HUK68_15890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUK68_15910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUK68_15915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUK68_15920	COG5007	Belongs to the BolA IbaG family
HUK68_15925	COG0842	Transport permease protein
HUK68_15930	COG1131	(ABC) transporter
HUK68_15945	COG2853	Lipoprotein
HUK68_15950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUK68_15955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUK68_15960	COG1127	ABC transporter
HUK68_15965	COG1126	abc transporter atp-binding protein
HUK68_15970	COG0765	amino acid transport
HUK68_15975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUK68_15990	COG0067	glutamate synthase
HUK68_15990	COG0069	glutamate synthase activity
HUK68_15990	COG0070	glutamate synthase
HUK68_16010	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUK68_16015	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUK68_16020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUK68_16060	COG1965	Belongs to the frataxin family
HUK68_16075	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HUK68_16080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUK68_16085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUK68_16090	COG1333	cytochrome c biogenesis protein
HUK68_16100	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUK68_16105	COG0596	Alpha beta hydrolase
HUK68_16110	COG1560	Kdo2-lipid A biosynthetic process
HUK68_16120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUK68_16135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUK68_16140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUK68_16140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUK68_16145	COG1051	belongs to the nudix hydrolase family
HUK68_16145	COG1056	cytidyltransferase-related domain
HUK68_16160	COG5383	Protein conserved in bacteria
HUK68_16165	COG0277	FAD linked oxidase domain protein
HUK68_16175	COG0583	DNA-binding transcription factor activity
HUK68_16190	COG2832	Protein of unknown function (DUF454)
HUK68_16195	COG3264	Mechanosensitive ion channel
HUK68_16195	COG1196	nuclear chromosome segregation
HUK68_16200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUK68_16205	COG0459	protein refolding
HUK68_16210	COG0166	Belongs to the GPI family
HUK68_16215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUK68_16235	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HUK68_16240	COG1765	OsmC-like protein
HUK68_16245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUK68_16250	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUK68_16335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUK68_16365	COG1132	(ABC) transporter
HUK68_16370	COG0189	ligase activity
HUK68_16370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUK68_16375	COG0189	ligase activity
HUK68_16375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUK68_16380	COG3045	CreA protein
HUK68_16390	COG0443	Heat shock 70 kDa protein
HUK68_16395	COG0443	Heat shock 70 kDa protein
HUK68_16430	COG2208	phosphoserine phosphatase activity
HUK68_16430	COG2770	Histidine kinase
HUK68_16465	COG1366	Belongs to the anti-sigma-factor antagonist family
HUK68_16470	COG4789	Type iii secretion
HUK68_16540	COG4669	(LipO)protein
HUK68_16570	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUK68_16575	COG4790	Type iii secretion
HUK68_16580	COG4794	Type iii secretion
HUK68_16585	COG4791	protein targeting
HUK68_16590	COG4792	protein secretion
HUK68_16630	COG5002	protein histidine kinase activity
HUK68_16630	COG5001	Diguanylate cyclase
HUK68_16630	COG3447	MASE1 domain protein
HUK68_16665	COG0778	Nitroreductase
HUK68_16670	COG0697	spore germination
HUK68_16675	COG1846	Transcriptional regulator
HUK68_16690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUK68_16710	COG4585	Histidine kinase
HUK68_16720	COG1522	sequence-specific DNA binding
HUK68_16725	COG2205	protein histidine kinase activity
HUK68_16730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUK68_16735	COG0583	DNA-binding transcription factor activity
HUK68_16740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUK68_16745	COG0739	heme binding
HUK68_16750	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUK68_16755	COG2814	Major facilitator Superfamily
HUK68_16760	COG0316	Belongs to the HesB IscA family
HUK68_16765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUK68_16770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUK68_16775	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HUK68_16780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUK68_16785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUK68_16790	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HUK68_16795	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUK68_16800	COG2814	Major facilitator Superfamily
HUK68_16805	COG2124	cytochrome p450
HUK68_16815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HUK68_16825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUK68_16835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUK68_16870	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_16875	COG0583	DNA-binding transcription factor activity
HUK68_16885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUK68_16895	COG0477	Major facilitator Superfamily
HUK68_16915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUK68_16920	COG4770	biotin carboxylase activity
HUK68_16930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUK68_16935	COG0025	NhaP-type Na H and K H
HUK68_16950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUK68_16955	COG3012	SEC-C Motif Domain Protein
HUK68_16965	COG1960	acyl-CoA dehydrogenase activity
HUK68_16970	COG4221	oxidoreductase activity
HUK68_16980	COG0183	Belongs to the thiolase family
HUK68_16985	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HUK68_16990	COG0288	reversible hydration of carbon dioxide
HUK68_16995	COG1960	acyl-CoA dehydrogenase activity
HUK68_17000	COG0789	Transcriptional regulator
HUK68_17010	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HUK68_17015	COG0745	RESPONSE REGULATOR receiver
HUK68_17145	COG0488	(ABC) transporter
HUK68_17150	COG2201	protein-glutamate methylesterase activity
HUK68_17155	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HUK68_17160	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HUK68_17165	COG0835	chemotaxis
HUK68_17170	COG0643	Histidine kinase
HUK68_17170	COG2198	Histidine kinase
HUK68_17205	COG1987	bacterial-type flagellum assembly
HUK68_17210	COG1338	Plays a role in the flagellum-specific transport system
HUK68_17215	COG3190	flagellar
HUK68_17220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUK68_17230	COG1580	Controls the rotational direction of flagella during chemotaxis
HUK68_17245	COG1157	protein secretion by the type III secretion system
HUK68_17250	COG1317	bacterial-type flagellum organization
HUK68_17265	COG1677	Flagellar hook-basal body complex protein FliE
HUK68_17280	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HUK68_17285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUK68_17290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUK68_17295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUK68_17300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUK68_17310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUK68_17325	COG1360	Flagellar Motor Protein
HUK68_17330	COG0745	RESPONSE REGULATOR receiver
HUK68_17335	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HUK68_17360	COG1191	sigma factor activity
HUK68_17380	COG1815	bacterial-type flagellum-dependent cell motility
HUK68_17385	COG1558	bacterial-type flagellum-dependent cell motility
HUK68_17390	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HUK68_17395	COG1749	Flagellar hook protein flgE
HUK68_17400	COG4787	bacterial-type flagellum-dependent cell motility
HUK68_17410	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HUK68_17415	COG1706	bacterial-type flagellum-dependent cell motility
HUK68_17430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUK68_17445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUK68_17450	COG0384	phenazine biosynthesis protein PhzF
HUK68_17470	COG0534	Mate efflux family protein
HUK68_17490	COG0786	glutamate:sodium symporter activity
HUK68_17495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUK68_17500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUK68_17510	COG0679	Auxin Efflux Carrier
HUK68_17515	COG0210	DNA helicase
HUK68_17540	COG0343	queuine tRNA-ribosyltransferase activity
HUK68_17545	COG5001	Diguanylate cyclase
HUK68_17545	COG3447	MASE1 domain protein
HUK68_17545	COG5002	protein histidine kinase activity
HUK68_17575	COG0625	glutathione transferase activity
HUK68_17580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUK68_17585	COG1074	ATP-dependent DNA helicase activity
HUK68_17590	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HUK68_17595	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_17600	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_17605	COG0426	domain, Protein
HUK68_17605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUK68_17610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUK68_17615	COG0583	DNA-binding transcription factor activity
HUK68_17625	COG1024	Enoyl-CoA hydratase
HUK68_17635	COG1960	acyl-CoA dehydrogenase activity
HUK68_17650	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_17655	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_17680	COG0765	amino acid transport
HUK68_17685	COG0765	amino acid transport
HUK68_17690	COG1126	abc transporter atp-binding protein
HUK68_17715	COG5002	protein histidine kinase activity
HUK68_17725	COG1196	nuclear chromosome segregation
HUK68_17725	COG3264	Mechanosensitive ion channel
HUK68_17735	COG2204	response regulator
HUK68_17740	COG5000	phosphorelay sensor kinase activity
HUK68_17750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUK68_17750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUK68_17760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUK68_17765	COG0085	RNA polymerase activity
HUK68_17770	COG0222	ribosome binding
HUK68_17775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUK68_17780	COG0081	regulation of translation
HUK68_17785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUK68_17795	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUK68_17805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUK68_17830	COG1309	transcriptional regulator
HUK68_17835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK68_17850	COG3245	cytochrome
HUK68_17880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUK68_17885	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUK68_17890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUK68_17895	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUK68_17900	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUK68_17905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUK68_17915	COG0356	it plays a direct role in the translocation of protons across the membrane
HUK68_17925	COG2921	Belongs to the UPF0250 family
HUK68_17930	COG0321	lipoyl(octanoyl) transferase activity
HUK68_17935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUK68_17940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUK68_17945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUK68_17955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUK68_17965	COG0678	peroxiredoxin activity
HUK68_17970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUK68_17975	COG0255	Belongs to the universal ribosomal protein uL29 family
HUK68_17980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUK68_17985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUK68_17990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUK68_17995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUK68_18000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUK68_18005	COG0089	rRNA binding
HUK68_18010	COG0088	Forms part of the polypeptide exit tunnel
HUK68_18015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUK68_18020	COG0051	transcription antitermination factor activity, RNA binding
HUK68_18025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUK68_18030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUK68_18035	COG0049	tRNA binding
HUK68_18040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUK68_18045	COG1686	Belongs to the peptidase S11 family
HUK68_18050	COG2945	thiolester hydrolase activity
HUK68_18055	COG3411	Ferredoxin
HUK68_18065	COG1981	membrane
HUK68_18075	COG0598	Magnesium transport protein CorA
HUK68_18085	COG2095	MarC family integral membrane protein
HUK68_18105	COG1127	ABC transporter
HUK68_18110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUK68_18125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUK68_18130	COG0765	amino acid transport
HUK68_18140	COG0768	penicillin binding
HUK68_18155	COG1077	Cell shape determining protein MreB Mrl
HUK68_18160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUK68_18165	COG0154	amidase activity
HUK68_18170	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUK68_18205	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUK68_18210	COG0708	Exodeoxyribonuclease III
HUK68_18215	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HUK68_18250	COG1968	undecaprenyl-diphosphatase activity
HUK68_18280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HUK68_18290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUK68_18305	COG0745	RESPONSE REGULATOR receiver
HUK68_18310	COG2205	protein histidine kinase activity
HUK68_18330	COG0438	transferase activity, transferring glycosyl groups
HUK68_18365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUK68_18375	COG0386	Belongs to the glutathione peroxidase family
HUK68_18385	COG0247	lactate metabolic process
HUK68_18390	COG0277	FAD linked oxidase domain protein
HUK68_18395	COG0004	ammonium transporteR
HUK68_18400	COG0347	Belongs to the P(II) protein family
HUK68_18415	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_18420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUK68_18425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUK68_18430	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_18445	COG3386	PFAM SMP-30 Gluconolaconase
HUK68_18455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_18470	COG0251	oxidation-reduction process
HUK68_18490	COG0756	dUTP diphosphatase activity
HUK68_18540	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUK68_18565	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUK68_18600	COG0606	chelatase, subunit chli
HUK68_18610	COG1024	Enoyl-CoA hydratase
HUK68_18655	COG0683	leucine binding
HUK68_18670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUK68_18675	COG1410	methionine synthase
HUK68_18675	COG0646	methionine synthase
HUK68_18700	COG3718	enzyme involved in inositol metabolism
HUK68_18705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUK68_18730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUK68_18760	COG1960	acyl-CoA dehydrogenase activity
HUK68_18765	COG1960	acyl-CoA dehydrogenase activity
HUK68_18770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUK68_18780	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HUK68_18830	COG1199	ATP-dependent helicase activity
HUK68_18830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUK68_18835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUK68_18840	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HUK68_18850	COG0850	regulation of cytokinetic process
HUK68_18855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUK68_18860	COG2233	PERMEase
HUK68_18875	COG2050	protein possibly involved in aromatic compounds catabolism
HUK68_18880	COG0583	DNA-binding transcription factor activity
HUK68_18895	COG2096	Adenosyltransferase
HUK68_18900	COG0277	FAD linked oxidase domain protein
HUK68_18925	COG0583	DNA-binding transcription factor activity
HUK68_18930	COG2814	Major facilitator Superfamily
HUK68_18935	COG0165	Argininosuccinate lyase
HUK68_18940	COG0165	Argininosuccinate lyase
HUK68_18945	COG1475	DNA binding
HUK68_18955	COG1192	Involved in chromosome partitioning
HUK68_18960	COG1280	lysine exporter protein (LysE YggA)
HUK68_18965	COG0357	Ribosomal RNA small subunit methyltransferase G
HUK68_18970	COG0445	tRNA wobble uridine modification
HUK68_18975	COG0625	glutathione transferase activity
HUK68_18980	COG1902	pentaerythritol trinitrate reductase activity
HUK68_18985	COG0840	transmembrane signaling receptor activity
HUK68_19000	COG0789	Transcriptional regulator
HUK68_19035	COG1022	Amp-dependent synthetase and ligase
HUK68_19040	COG0183	Belongs to the thiolase family
HUK68_19045	COG2974	May be involved in recombination
HUK68_19055	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HUK68_19065	COG1199	ATP-dependent helicase activity
HUK68_19075	COG0604	alcohol dehydrogenase
HUK68_19075	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_19075	COG3321	synthase
HUK68_19080	COG0156	8-amino-7-oxononanoate synthase activity
HUK68_19090	COG0861	Integral membrane protein TerC family
HUK68_19095	COG1368	sulfuric ester hydrolase activity
HUK68_19140	COG0529	Catalyzes the synthesis of activated sulfate
HUK68_19150	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HUK68_19155	COG0438	transferase activity, transferring glycosyl groups
HUK68_19190	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUK68_19195	COG2010	Cytochrome c
HUK68_19195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUK68_19200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUK68_19200	COG2010	Cytochrome c
HUK68_19205	COG2080	2 iron, 2 sulfur cluster binding
HUK68_19210	COG3829	transcription factor binding
HUK68_19215	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_19235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUK68_19240	COG1116	anion transmembrane transporter activity
HUK68_19250	COG1802	Transcriptional regulator
HUK68_19275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUK68_19280	COG1116	anion transmembrane transporter activity
HUK68_19285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUK68_19290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUK68_19310	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_19320	COG2814	Major facilitator Superfamily
HUK68_19325	COG0583	DNA-binding transcription factor activity
HUK68_19380	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HUK68_19385	COG2985	domain, Protein
HUK68_19390	COG2985	domain, Protein
HUK68_19410	COG1566	PFAM secretion protein HlyD family protein
HUK68_19425	COG1690	Belongs to the RtcB family
HUK68_19450	COG1192	Involved in chromosome partitioning
HUK68_19460	COG4251	negative regulation of phosphorylation
HUK68_19460	COG3706	GGDEF domain
HUK68_19460	COG2203	Gaf domain
HUK68_19460	COG5001	Diguanylate cyclase
HUK68_19480	COG3846	protein secretion by the type IV secretion system
HUK68_19505	COG3701	Conjugal transfer protein
HUK68_19510	COG3451	type IV secretory pathway VirB4
HUK68_19515	COG5268	conjugation
HUK68_19520	COG3838	Conjugal transfer protein Trbc
HUK68_19525	COG4962	Type ii secretion system protein e
HUK68_19535	COG0656	L-ascorbic acid biosynthetic process
HUK68_19540	COG0583	DNA-binding transcription factor activity
HUK68_19570	COG2831	hemolysin activation secretion protein
HUK68_19620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUK68_19630	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_19645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUK68_19650	COG0251	oxidation-reduction process
HUK68_19665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUK68_19675	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_19690	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_19695	COG0583	DNA-binding transcription factor activity
HUK68_19730	COG0596	Alpha beta hydrolase
HUK68_19745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUK68_19745	COG2169	Transcriptional regulator
HUK68_19760	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUK68_19765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUK68_19800	COG4993	Dehydrogenase
HUK68_19845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_19850	COG1024	Enoyl-CoA hydratase
HUK68_19855	COG1960	acyl-CoA dehydrogenase activity
HUK68_19860	COG1960	acyl-CoA dehydrogenase activity
HUK68_19865	COG0183	Belongs to the thiolase family
HUK68_19870	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUK68_19870	COG1024	Enoyl-CoA hydratase
HUK68_19875	COG0583	DNA-binding transcription factor activity
HUK68_19890	COG1309	transcriptional regulator
HUK68_19895	COG2814	Major facilitator Superfamily
HUK68_19900	COG1846	Transcriptional regulator
HUK68_19905	COG1538	Outer membrane efflux protein
HUK68_19910	COG1566	PFAM secretion protein HlyD family protein
HUK68_19915	COG2814	Major facilitator Superfamily
HUK68_19920	COG1132	(ABC) transporter
HUK68_19940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK68_19945	COG0657	acetylesterase activity
HUK68_19980	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_19985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_19995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUK68_20005	COG1877	trehalose-phosphatase activity
HUK68_20015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUK68_20030	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUK68_20035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUK68_20045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUK68_20050	COG0583	DNA-binding transcription factor activity
HUK68_20080	COG2814	Major facilitator Superfamily
HUK68_20085	COG2814	Major facilitator Superfamily
HUK68_20115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUK68_20130	COG0625	glutathione transferase activity
HUK68_20140	COG0277	FAD linked oxidase domain protein
HUK68_20175	COG0765	amino acid transport
HUK68_20180	COG0765	amino acid transport
HUK68_20185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUK68_20190	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_20200	COG1116	anion transmembrane transporter activity
HUK68_20205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUK68_20215	COG0154	amidase activity
HUK68_20235	COG1024	Enoyl-CoA hydratase
HUK68_20240	COG0045	succinate-CoA ligase (ADP-forming) activity
HUK68_20240	COG1042	CoA-binding domain protein
HUK68_20240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUK68_20255	COG1960	acyl-CoA dehydrogenase activity
HUK68_20260	COG0672	)-iron permease
HUK68_20265	COG0038	chloride channel
HUK68_20280	COG3706	GGDEF domain
HUK68_20285	COG0419	ATPase involved in DNA repair
HUK68_20290	COG0420	3'-5' exonuclease activity
HUK68_20305	COG0697	spore germination
HUK68_20315	COG0583	DNA-binding transcription factor activity
HUK68_20340	COG0583	DNA-binding transcription factor activity
HUK68_20350	COG2223	nitrite transmembrane transporter activity
HUK68_20365	COG2080	2 iron, 2 sulfur cluster binding
HUK68_20370	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUK68_20375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUK68_20385	COG2032	superoxide dismutase activity
HUK68_20395	COG4221	oxidoreductase activity
HUK68_20400	COG1522	sequence-specific DNA binding
HUK68_20405	COG2962	Rard protein
HUK68_20450	COG2094	Belongs to the DNA glycosylase MPG family
HUK68_20455	COG3634	alkyl hydroperoxide reductase activity
HUK68_20505	COG0587	DNA-directed DNA polymerase activity
HUK68_20520	COG1396	sequence-specific DNA binding
HUK68_20525	COG3550	peptidyl-serine autophosphorylation
HUK68_20545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUK68_20555	COG0583	DNA-binding transcription factor activity
HUK68_20590	COG0583	DNA-binding transcription factor activity
HUK68_20595	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_20600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_20615	COG1024	Enoyl-CoA hydratase
HUK68_20625	COG0702	epimerase
HUK68_20650	COG4774	siderophore transport
HUK68_20655	COG0604	alcohol dehydrogenase
HUK68_20655	COG3321	synthase
HUK68_20670	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_20675	COG1309	transcriptional regulator
HUK68_20705	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_20710	COG1960	acyl-CoA dehydrogenase activity
HUK68_20725	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HUK68_20730	COG2072	flavoprotein involved in K transport
HUK68_20735	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_20780	COG1024	Enoyl-CoA hydratase
HUK68_20830	COG0477	Major facilitator Superfamily
HUK68_20835	COG2267	carboxylic ester hydrolase activity
HUK68_20870	COG2423	ornithine cyclodeaminase activity
HUK68_20885	COG0583	DNA-binding transcription factor activity
HUK68_20890	COG0789	Transcriptional regulator
HUK68_20900	COG0243	molybdopterin cofactor binding
HUK68_20905	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HUK68_20920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUK68_20930	COG3712	iron ion homeostasis
HUK68_20935	COG1595	DNA-templated transcription, initiation
HUK68_20950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUK68_20980	COG2200	EAL domain
HUK68_20990	COG1201	RNA secondary structure unwinding
HUK68_20995	COG1793	dna ligase
HUK68_21000	COG1793	dna ligase
HUK68_21000	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUK68_21005	COG1064	alcohol dehydrogenase
HUK68_21035	COG1349	DNA-binding transcription factor activity
HUK68_21045	COG3395	kinase activity
HUK68_21050	COG0235	Class ii aldolase
HUK68_21055	COG0405	Gamma-glutamyltransferase
HUK68_21060	COG2814	Major facilitator Superfamily
HUK68_21070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUK68_21080	COG3842	ATPase activity
HUK68_21085	COG1840	ABC-type Fe3 transport system, periplasmic component
HUK68_21090	COG1178	ABC-type Fe3 transport system permease component
HUK68_21115	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_21145	COG3829	transcription factor binding
HUK68_21150	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HUK68_21155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUK68_21160	COG1024	Enoyl-CoA hydratase
HUK68_21175	COG0583	DNA-binding transcription factor activity
HUK68_21185	COG1562	ergosterol biosynthetic process
HUK68_21210	COG0028	Belongs to the TPP enzyme family
HUK68_21220	COG0693	protein deglycase activity
HUK68_21230	COG1960	acyl-CoA dehydrogenase activity
HUK68_21235	COG0318	PFAM AMP-dependent synthetase and ligase
HUK68_21245	COG0475	glutathione-regulated potassium exporter activity
HUK68_21245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUK68_21255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUK68_21265	COG4115	mRNA cleavage
HUK68_21270	COG2161	toxin-antitoxin pair type II binding
HUK68_21300	COG4804	nuclease activity
HUK68_21335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUK68_21350	COG0471	metal ion transport
HUK68_21355	COG0569	domain protein
HUK68_21355	COG2985	domain, Protein
HUK68_21360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUK68_21390	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HUK68_21395	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HUK68_21400	COG0583	DNA-binding transcription factor activity
HUK68_21430	COG1116	anion transmembrane transporter activity
HUK68_21470	COG0840	transmembrane signaling receptor activity
HUK68_21510	COG4774	siderophore transport
HUK68_21520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUK68_21525	COG1120	ATPase activity
HUK68_21540	COG0069	glutamate synthase activity
HUK68_21550	COG1309	transcriptional regulator
HUK68_21555	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HUK68_21555	COG0506	proline dehydrogenase activity
HUK68_21555	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HUK68_21570	COG0235	Class ii aldolase
HUK68_21595	COG1053	succinate dehydrogenase
HUK68_21640	COG0840	transmembrane signaling receptor activity
HUK68_21660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_21665	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUK68_21670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUK68_21675	COG1121	(ABC) transporter
HUK68_21695	COG0784	Response regulator, receiver
HUK68_21695	COG4191	Histidine kinase
HUK68_21700	COG3685	Protein conserved in bacteria
HUK68_21705	COG0667	Aldo Keto reductase
HUK68_21715	COG2271	Major facilitator Superfamily
HUK68_21720	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_21730	COG0583	DNA-binding transcription factor activity
HUK68_21735	COG1538	Outer membrane efflux protein
HUK68_21740	COG1136	(ABC) transporter
HUK68_21740	COG0577	efflux transmembrane transporter activity
HUK68_21745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK68_21775	COG2706	6-phosphogluconolactonase activity
HUK68_21790	COG0583	DNA-binding transcription factor activity
HUK68_21800	COG2814	Major facilitator Superfamily
HUK68_21805	COG0730	response to heat
HUK68_21810	COG0028	Belongs to the TPP enzyme family
HUK68_21825	COG0583	DNA-binding transcription factor activity
HUK68_21835	COG1595	DNA-templated transcription, initiation
HUK68_21840	COG3712	iron ion homeostasis
HUK68_21850	COG4774	siderophore transport
HUK68_21875	COG1024	Enoyl-CoA hydratase
HUK68_21885	COG1960	acyl-CoA dehydrogenase activity
HUK68_21905	COG1028	Short-chain dehydrogenase reductase Sdr
HUK68_21910	COG0183	Belongs to the thiolase family
HUK68_21935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUK68_21940	COG1024	Enoyl-CoA hydratase
HUK68_21945	COG0583	DNA-binding transcription factor activity
HUK68_21955	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUK68_22000	COG0625	glutathione transferase activity
HUK68_22005	COG2707	UPF0756 membrane protein
HUK68_22010	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUK68_22025	COG2072	flavoprotein involved in K transport
HUK68_22040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUK68_22050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUK68_22060	COG0725	ABC transporter, periplasmic molybdate-binding protein
HUK68_22065	COG4149	molybdate abc transporter
HUK68_22080	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HUK68_22085	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HUK68_22100	COG2205	protein histidine kinase activity
HUK68_22105	COG0745	RESPONSE REGULATOR receiver
HUK68_22110	COG2329	Antibiotic biosynthesis monooxygenase
HUK68_22115	COG3040	lipid binding
HUK68_22125	COG0697	spore germination
HUK68_22140	COG0583	DNA-binding transcription factor activity
HUK68_22165	COG3665	Urea carboxylase-associated protein
HUK68_22230	COG3384	dioxygenase
HUK68_22250	COG1192	Involved in chromosome partitioning
HUK68_22300	COG3504	Conjugal transfer protein
HUK68_22305	COG2948	multi-organism process
HUK68_22360	COG0352	thiamine-phosphate diphosphorylase activity
HUK68_22370	COG0675	Transposase, IS605 OrfB family
HUK68_22395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUK68_22400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUK68_22425	COG0583	DNA-binding transcription factor activity
HUK68_22435	COG2963	transposase activity
HUK68_22485	COG3328	transposase activity
HUK68_22520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUK68_22525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUK68_22535	COG0583	DNA-binding transcription factor activity
HUK68_22610	COG1902	pentaerythritol trinitrate reductase activity
HUK68_22625	COG3012	SEC-C Motif Domain Protein
HUK68_22630	COG4372	Transposase
HUK68_22650	COG0832	Belongs to the urease beta subunit family
HUK68_22650	COG0831	urea catabolic process
HUK68_22655	COG0804	urea catabolic process
HUK68_22660	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUK68_22665	COG0829	nickel cation binding
HUK68_22705	COG0411	ABC transporter
HUK68_22730	COG0251	oxidation-reduction process
HUK68_22750	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_22760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUK68_22765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUK68_22790	COG1760	l-serine dehydratase
HUK68_22795	COG0583	DNA-binding transcription factor activity
HUK68_22800	COG3181	Tripartite tricarboxylate transporter family receptor
HUK68_22805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUK68_22820	COG2175	clavaminate synthase activity
HUK68_22830	COG1959	2 iron, 2 sulfur cluster binding
HUK68_22865	COG4372	Transposase
HUK68_22895	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUK68_22900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUK68_22925	COG2205	protein histidine kinase activity
HUK68_22980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUK68_22995	COG0431	NADPH-dependent FMN reductase
HUK68_23000	COG1393	Belongs to the ArsC family
HUK68_23005	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUK68_23040	COG0671	phosphoesterase, PA-phosphatase related
HUK68_23050	COG0789	Transcriptional regulator
HUK68_23080	COG3311	Transcriptional regulator
HUK68_23125	COG2916	Histone family protein nucleoid-structuring protein H-NS
HUK68_23135	COG3181	Tripartite tricarboxylate transporter family receptor