locus-tag	class	description
Acav_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Acav_0007	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Acav_0010	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Acav_0013	COG4650	regulator
Acav_0015	COG1690	Belongs to the RtcB family
Acav_0016	COG3541	Predicted nucleotidyltransferase
Acav_0017	COG0430	RNA-3'-phosphate cyclase activity
Acav_0019	COG1764	response to oxidative stress
Acav_0023	COG1199	ATP-dependent helicase activity
Acav_0026	COG2176	DNA-directed DNA polymerase activity
Acav_0030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Acav_0031	COG0791	NLP P60 protein
Acav_0032	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Acav_0036	COG2974	May be involved in recombination
Acav_0037	COG0700	Nucleoside recognition
Acav_0041	COG0183	Belongs to the thiolase family
Acav_0042	COG0789	Transcriptional regulator
Acav_0045	COG0840	transmembrane signaling receptor activity
Acav_0052	COG0642	Histidine kinase
Acav_0054	COG1902	pentaerythritol trinitrate reductase activity
Acav_0055	COG4521	taurine ABC transporter
Acav_0056	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Acav_0057	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Acav_0061	COG0445	tRNA wobble uridine modification
Acav_0062	COG0357	Ribosomal RNA small subunit methyltransferase G
Acav_0063	COG1280	lysine exporter protein (LysE YggA)
Acav_0064	COG1192	Involved in chromosome partitioning
Acav_0070	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_0071	COG1024	Enoyl-CoA hydratase
Acav_0073	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Acav_0076	COG4977	sequence-specific DNA binding
Acav_0079	COG0493	'glutamate synthase
Acav_0084	COG0546	phosphoglycolate phosphatase activity
Acav_0084	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Acav_0087	COG2272	Belongs to the type-B carboxylesterase lipase family
Acav_0091	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Acav_0098	COG3411	Ferredoxin
Acav_0102	COG2329	Antibiotic biosynthesis monooxygenase
Acav_0121	COG0277	FAD linked oxidase domain protein
Acav_0124	COG2096	Adenosyltransferase
Acav_0129	COG2050	protein possibly involved in aromatic compounds catabolism
Acav_0132	COG2233	PERMEase
Acav_0134	COG0840	transmembrane signaling receptor activity
Acav_0136	COG2203	Gaf domain
Acav_0136	COG2199	diguanylate cyclase activity
Acav_0137	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Acav_0143	COG1116	anion transmembrane transporter activity
Acav_0144	COG0395	ABC-type sugar transport system, permease component
Acav_0145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Acav_0146	COG0583	DNA-binding transcription factor activity
Acav_0150	COG0501	Belongs to the peptidase M48B family
Acav_0152	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Acav_0154	COG2423	ornithine cyclodeaminase activity
Acav_0156	COG1183	phosphatidylcholine synthase activity
Acav_0157	COG0850	regulation of cytokinetic process
Acav_0159	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Acav_0160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Acav_0163	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Acav_0164	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acav_0172	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Acav_0173	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_0174	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Acav_0176	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Acav_0177	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Acav_0180	COG1960	acyl-CoA dehydrogenase activity
Acav_0185	COG2271	Major facilitator Superfamily
Acav_0199	COG0840	transmembrane signaling receptor activity
Acav_0204	COG2204	response regulator
Acav_0208	COG0583	DNA-binding transcription factor activity
Acav_0211	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Acav_0220	COG1309	transcriptional regulator
Acav_0224	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Acav_0226	COG2326	polyphosphate kinase activity
Acav_0233	COG0745	RESPONSE REGULATOR receiver
Acav_0233	COG3706	GGDEF domain
Acav_0242	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acav_0244	COG0583	DNA-binding transcription factor activity
Acav_0249	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acav_0250	COG0583	DNA-binding transcription factor activity
Acav_0255	COG0583	DNA-binding transcription factor activity
Acav_0259	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
Acav_0261	COG0765	amino acid transport
Acav_0262	COG0765	amino acid transport
Acav_0266	COG0646	methionine synthase
Acav_0266	COG1410	methionine synthase
Acav_0279	COG0583	DNA-binding transcription factor activity
Acav_0280	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_0282	COG0840	transmembrane signaling receptor activity
Acav_0284	COG4191	Histidine kinase
Acav_0286	COG0606	chelatase, subunit chli
Acav_0288	COG0347	Belongs to the P(II) protein family
Acav_0289	COG0004	ammonium transporteR
Acav_0298	COG3501	Rhs element vgr protein
Acav_0299	COG0277	FAD linked oxidase domain protein
Acav_0301	COG0247	lactate metabolic process
Acav_0307	COG0386	Belongs to the glutathione peroxidase family
Acav_0309	COG0477	Major facilitator Superfamily
Acav_0310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Acav_0312	COG0747	negative chemotaxis
Acav_0316	COG0625	glutathione transferase activity
Acav_0317	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Acav_0326	COG1215	transferase activity, transferring glycosyl groups
Acav_0330	COG0477	Major facilitator Superfamily
Acav_0331	COG2205	protein histidine kinase activity
Acav_0332	COG0745	RESPONSE REGULATOR receiver
Acav_0333	COG2211	Major facilitator Superfamily
Acav_0336	COG0501	Belongs to the peptidase M48B family
Acav_0337	COG0471	metal ion transport
Acav_0338	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Acav_0341	COG2199	diguanylate cyclase activity
Acav_0341	COG2203	Gaf domain
Acav_0343	COG0583	DNA-binding transcription factor activity
Acav_0344	COG2814	Major facilitator Superfamily
Acav_0345	COG0656	L-ascorbic acid biosynthetic process
Acav_0346	COG0708	Exodeoxyribonuclease III
Acav_0347	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Acav_0349	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Acav_0352	COG0154	amidase activity
Acav_0353	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Acav_0354	COG1077	Cell shape determining protein MreB Mrl
Acav_0356	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Acav_0357	COG0768	penicillin binding
Acav_0360	COG0765	amino acid transport
Acav_0361	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acav_0362	COG1760	l-serine dehydratase
Acav_0366	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Acav_0367	COG1127	ABC transporter
Acav_0378	COG0175	sulfate reduction
Acav_0379	COG3237	CsbD-like
Acav_0383	COG4452	Inner membrane protein CreD
Acav_0384	COG2205	protein histidine kinase activity
Acav_0385	COG0745	RESPONSE REGULATOR receiver
Acav_0386	COG2095	MarC family integral membrane protein
Acav_0387	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_0388	COG0412	Dienelactone hydrolase
Acav_0390	COG1566	PFAM secretion protein HlyD family protein
Acav_0393	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Acav_0393	COG0519	Catalyzes the synthesis of GMP from XMP
Acav_0394	COG0598	Magnesium transport protein CorA
Acav_0399	COG2945	thiolester hydrolase activity
Acav_0400	COG1686	Belongs to the peptidase S11 family
Acav_0401	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Acav_0402	COG0049	tRNA binding
Acav_0403	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Acav_0404	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Acav_0405	COG0051	transcription antitermination factor activity, RNA binding
Acav_0406	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Acav_0407	COG0088	Forms part of the polypeptide exit tunnel
Acav_0408	COG0089	rRNA binding
Acav_0409	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Acav_0410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Acav_0411	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Acav_0412	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Acav_0413	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Acav_0414	COG0255	Belongs to the universal ribosomal protein uL29 family
Acav_0415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Acav_0416	COG0678	peroxiredoxin activity
Acav_0418	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Acav_0421	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Acav_0422	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Acav_0425	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Acav_0426	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Acav_0427	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Acav_0428	COG2205	protein histidine kinase activity
Acav_0429	COG0745	RESPONSE REGULATOR receiver
Acav_0432	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Acav_0433	COG0321	lipoyl(octanoyl) transferase activity
Acav_0434	COG2921	Belongs to the UPF0250 family
Acav_0436	COG0356	it plays a direct role in the translocation of protons across the membrane
Acav_0438	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Acav_0439	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Acav_0440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Acav_0441	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Acav_0442	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Acav_0443	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Acav_0444	COG1793	dna ligase
Acav_0444	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Acav_0445	COG1793	dna ligase
Acav_0446	COG1201	RNA secondary structure unwinding
Acav_0458	COG1538	Outer membrane efflux protein
Acav_0459	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Acav_0460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Acav_0464	COG0121	glutamine amidotransferase
Acav_0465	COG2814	Major facilitator Superfamily
Acav_0466	COG1942	4-Oxalocrotonate Tautomerase
Acav_0469	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Acav_0475	COG0018	arginyl-trna synthetase
Acav_0477	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Acav_0479	COG1137	ATPase activity
Acav_0480	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Acav_0481	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Acav_0486	COG4178	(ABC) transporter
Acav_0488	COG3012	SEC-C Motif Domain Protein
Acav_0488	COG3318	Belongs to the UPF0149 family
Acav_0489	COG0659	secondary active sulfate transmembrane transporter activity
Acav_0492	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Acav_0497	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_0500	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Acav_0503	COG2967	ApaG domain
Acav_0504	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Acav_0506	COG0546	phosphoglycolate phosphatase activity
Acav_0510	COG2207	Transcriptional regulator
Acav_0514	COG4794	Type iii secretion
Acav_0515	COG4790	Type iii secretion
Acav_0518	COG4789	Type iii secretion
Acav_0519	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Acav_0544	COG0500	methyltransferase
Acav_0545	COG1196	nuclear chromosome segregation
Acav_0545	COG0741	lytic transglycosylase activity
Acav_0545	COG0739	heme binding
Acav_0550	COG0512	Glutamine amidotransferase of anthranilate synthase
Acav_0552	COG1280	lysine exporter protein (LysE YggA)
Acav_0553	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Acav_0555	COG0134	indole-3-glycerol-phosphate synthase activity
Acav_0556	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Acav_0559	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Acav_0565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Acav_0567	COG0783	Belongs to the Dps family
Acav_0568	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Acav_0573	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Acav_0575	COG3842	ATPase activity
Acav_0576	COG3842	ATPase activity
Acav_0578	COG0395	ABC-type sugar transport system, permease component
Acav_0582	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Acav_0583	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Acav_0584	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Acav_0585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Acav_0586	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Acav_0587	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Acav_0588	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Acav_0589	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Acav_0590	COG1841	ribosomal large subunit assembly
Acav_0591	COG0200	Binds to the 23S rRNA
Acav_0592	COG0201	protein transport
Acav_0593	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Acav_0594	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Acav_0595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Acav_0596	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Acav_0597	COG0202	RNA polymerase activity
Acav_0598	COG0203	ribosomal protein L17
Acav_0599	COG0443	Heat shock 70 kDa protein
Acav_0600	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Acav_0601	COG0792	nuclease activity
Acav_0602	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Acav_0603	COG2823	Periplasmic or secreted lipoprotein
Acav_0604	COG2084	Dehydrogenase
Acav_0606	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Acav_0608	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Acav_0611	COG2733	membrane
Acav_0615	COG0277	FAD linked oxidase domain protein
Acav_0617	COG0583	DNA-binding transcription factor activity
Acav_0622	COG1285	pathogenesis
Acav_0624	COG3850	Histidine kinase
Acav_0625	COG2197	response regulator
Acav_0629	COG2223	nitrite transmembrane transporter activity
Acav_0630	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Acav_0631	COG1140	nitrate reductase beta subunit
Acav_0632	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Acav_0633	COG2181	nitrate reductase activity
Acav_0634	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Acav_0635	COG0288	reversible hydration of carbon dioxide
Acav_0639	COG3945	hemerythrin HHE cation binding domain
Acav_0641	COG0477	Major facilitator Superfamily
Acav_0648	COG0583	DNA-binding transcription factor activity
Acav_0656	COG1272	protein, Hemolysin III
Acav_0662	COG3501	Rhs element vgr protein
Acav_0670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Acav_0671	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Acav_0673	COG0129	dihydroxy-acid dehydratase activity
Acav_0674	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Acav_0676	COG0583	DNA-binding transcription factor activity
Acav_0677	COG1741	Belongs to the pirin family
Acav_0678	COG1335	isochorismatase
Acav_0683	COG0243	molybdopterin cofactor binding
Acav_0685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acav_0686	COG1473	amidohydrolase
Acav_0688	COG0840	transmembrane signaling receptor activity
Acav_0691	COG0519	Catalyzes the synthesis of GMP from XMP
Acav_0693	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Acav_0701	COG0559	Belongs to the binding-protein-dependent transport system permease family
Acav_0702	COG0411	ABC transporter
Acav_0704	COG3267	Type II secretory pathway component ExeA
Acav_0704	COG3409	Peptidoglycan-binding domain 1 protein
Acav_0705	COG3266	domain, Protein
Acav_0718	COG4269	membrane
Acav_0725	COG1733	regulation of RNA biosynthetic process
Acav_0726	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Acav_0729	COG0625	glutathione transferase activity
Acav_0730	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Acav_0732	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Acav_0737	COG3447	MASE1 domain protein
Acav_0737	COG5001	Diguanylate cyclase
Acav_0737	COG5002	protein histidine kinase activity
Acav_0738	COG0523	cobalamin synthesis protein
Acav_0739	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Acav_0741	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Acav_0742	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Acav_0743	COG2001	Belongs to the MraZ family
Acav_0744	COG0275	rRNA processing
Acav_0747	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Acav_0748	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Acav_0749	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Acav_0750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Acav_0751	COG0772	Belongs to the SEDS family
Acav_0752	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Acav_0753	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Acav_0754	COG1181	Belongs to the D-alanine--D-alanine ligase family
Acav_0755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Acav_0757	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Acav_0758	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Acav_0760	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Acav_0761	COG0840	transmembrane signaling receptor activity
Acav_0764	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Acav_0765	COG0575	Belongs to the CDS family
Acav_0771	COG1414	Transcriptional regulator
Acav_0772	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Acav_0773	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Acav_0775	COG0557	exoribonuclease II activity
Acav_0777	COG3150	esterase
Acav_0778	COG0772	Belongs to the SEDS family
Acav_0779	COG0154	amidase activity
Acav_0780	COG0312	modulator of DNA gyrase
Acav_0783	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Acav_0785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Acav_0787	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Acav_0788	COG0511	ligase activity, forming carbon-carbon bonds
Acav_0790	COG0439	Biotin carboxylase
Acav_0791	COG2264	protein methyltransferase activity
Acav_0795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Acav_0802	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Acav_0804	COG2204	response regulator
Acav_0806	COG2205	protein histidine kinase activity
Acav_0807	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Acav_0809	COG0456	acetyltransferase
Acav_0814	COG1595	DNA-templated transcription, initiation
Acav_0816	COG0642	Histidine kinase
Acav_0819	COG1538	Outer membrane efflux protein
Acav_0821	COG0410	ABC transporter
Acav_0825	COG0559	Belongs to the binding-protein-dependent transport system permease family
Acav_0826	COG0411	ABC transporter
Acav_0828	COG0431	NADPH-dependent FMN reductase
Acav_0831	COG3829	transcription factor binding
Acav_0832	COG1024	Enoyl-CoA hydratase
Acav_0834	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Acav_0835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Acav_0837	COG0012	GTP binding
Acav_0841	COG1238	metal cluster binding
Acav_0842	COG3706	GGDEF domain
Acav_0844	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Acav_0845	COG0138	bifunctional purine biosynthesis protein purh
Acav_0847	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Acav_0848	COG0352	thiamine-phosphate diphosphorylase activity
Acav_0848	COG0351	phosphomethylpyrimidine kinase
Acav_0848	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Acav_0849	COG1773	rubredoxin
Acav_0852	COG0835	chemotaxis
Acav_0853	COG0840	transmembrane signaling receptor activity
Acav_0854	COG0643	Histidine kinase
Acav_0854	COG2198	Histidine kinase
Acav_0855	COG0415	Belongs to the DNA photolyase family
Acav_0856	COG1678	Uncharacterized ACR, COG1678
Acav_0857	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Acav_0858	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Acav_0859	COG0540	Belongs to the ATCase OTCase family
Acav_0864	COG2431	L-lysine efflux transmembrane transporter activity
Acav_0865	COG3842	ATPase activity
Acav_0866	COG1178	ABC-type Fe3 transport system permease component
Acav_0876	COG2165	general secretion pathway protein
Acav_0880	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Acav_0881	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Acav_0882	COG1765	OsmC-like protein
Acav_0883	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Acav_0886	COG0601	transmembrane transport
Acav_0887	COG1473	amidohydrolase
Acav_0888	COG0747	negative chemotaxis
Acav_0889	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Acav_0890	COG0444	Belongs to the ABC transporter superfamily
Acav_0891	COG4608	Belongs to the ABC transporter superfamily
Acav_0894	COG0840	transmembrane signaling receptor activity
Acav_0896	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Acav_0899	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Acav_0900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Acav_0901	COG0166	Belongs to the GPI family
Acav_0902	COG0840	transmembrane signaling receptor activity
Acav_0904	COG1175	transmembrane transport
Acav_0905	COG0395	ABC-type sugar transport system, permease component
Acav_0907	COG0246	Mannitol dehydrogenase
Acav_0909	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Acav_0911	COG4753	response regulator
Acav_0911	COG2207	Transcriptional regulator
Acav_0912	COG1070	Carbohydrate kinase
Acav_0913	COG0459	protein refolding
Acav_0914	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Acav_0915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Acav_0917	COG2192	nodulation
Acav_0921	COG0463	Glycosyl transferase, family 2
Acav_0925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Acav_0935	COG0438	transferase activity, transferring glycosyl groups
Acav_0936	COG0438	transferase activity, transferring glycosyl groups
Acav_0938	COG1309	transcriptional regulator
Acav_0939	COG0493	'glutamate synthase
Acav_0941	COG1953	Uracil, thiamine, allantoin
Acav_0948	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acav_0948	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Acav_0949	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Acav_0952	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Acav_0954	COG1560	Kdo2-lipid A biosynthetic process
Acav_0956	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Acav_0958	COG1333	cytochrome c biogenesis protein
Acav_0959	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Acav_0960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Acav_0961	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Acav_0965	COG1965	Belongs to the frataxin family
Acav_0973	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Acav_0974	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Acav_0975	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Acav_0979	COG0070	glutamate synthase
Acav_0979	COG0069	glutamate synthase activity
Acav_0979	COG0067	glutamate synthase
Acav_0981	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acav_0982	COG0765	amino acid transport
Acav_0983	COG1126	abc transporter atp-binding protein
Acav_0984	COG1127	ABC transporter
Acav_0985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Acav_0986	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Acav_0991	COG1131	(ABC) transporter
Acav_0992	COG0842	Transport permease protein
Acav_0993	COG5007	Belongs to the BolA IbaG family
Acav_0994	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Acav_0995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Acav_0999	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acav_1002	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Acav_1003	COG0131	Imidazoleglycerol-phosphate dehydratase
Acav_1004	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Acav_1005	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Acav_1009	COG0438	transferase activity, transferring glycosyl groups
Acav_1015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Acav_1016	COG1301	dicarboxylic acid transport
Acav_1018	COG0107	imidazoleglycerol-phosphate synthase activity
Acav_1019	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Acav_1020	COG0140	phosphoribosyl-ATP diphosphatase activity
Acav_1023	COG0537	adenosine 5'-monophosphoramidase activity
Acav_1024	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Acav_1025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Acav_1026	COG0805	protein transport
Acav_1037	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Acav_1040	COG0714	Associated with various cellular activities
Acav_1041	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Acav_1042	COG0084	hydrolase, TatD family'
Acav_1044	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Acav_1052	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_1055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Acav_1057	COG1070	Carbohydrate kinase
Acav_1060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Acav_1063	COG0829	nickel cation binding
Acav_1067	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Acav_1070	COG3622	Belongs to the hyi family
Acav_1074	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Acav_1075	COG1116	anion transmembrane transporter activity
Acav_1078	COG0280	phosphate acetyltransferase
Acav_1078	COG0281	malic enzyme
Acav_1079	COG2233	PERMEase
Acav_1082	COG1953	Uracil, thiamine, allantoin
Acav_1083	COG2186	Transcriptional regulator
Acav_1084	COG0840	transmembrane signaling receptor activity
Acav_1085	COG1301	dicarboxylic acid transport
Acav_1093	COG1132	(ABC) transporter
Acav_1098	COG0367	asparagine synthase
Acav_1102	COG0297	glycogen (starch) synthase activity
Acav_1102	COG0438	transferase activity, transferring glycosyl groups
Acav_1103	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Acav_1105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Acav_1106	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acav_1109	COG2186	Transcriptional regulator
Acav_1112	COG0405	Gamma-glutamyltransferase
Acav_1120	COG0251	oxidation-reduction process
Acav_1125	COG2022	thiamine diphosphate biosynthetic process
Acav_1125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acav_1126	COG3447	MASE1 domain protein
Acav_1126	COG5002	protein histidine kinase activity
Acav_1126	COG5001	Diguanylate cyclase
Acav_1130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Acav_1133	COG1129	ABC transporter
Acav_1137	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Acav_1140	COG0583	DNA-binding transcription factor activity
Acav_1141	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acav_1142	COG1126	abc transporter atp-binding protein
Acav_1144	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acav_1148	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Acav_1150	COG2366	antibiotic biosynthetic process
Acav_1151	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Acav_1153	COG0402	S-adenosylhomocysteine deaminase activity
Acav_1154	COG0717	Belongs to the dCTP deaminase family
Acav_1157	COG2321	neutral zinc metallopeptidase
Acav_1158	COG0513	Belongs to the DEAD box helicase family
Acav_1159	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Acav_1160	COG2916	Histone family protein nucleoid-structuring protein H-NS
Acav_1161	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Acav_1162	COG5001	Diguanylate cyclase
Acav_1166	COG3483	tryptophan 2,3-dioxygenase activity
Acav_1168	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Acav_1169	COG1522	sequence-specific DNA binding
Acav_1176	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Acav_1177	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Acav_1179	COG0579	oxidoreductase
Acav_1180	COG0268	Binds directly to 16S ribosomal RNA
Acav_1181	COG0728	peptidoglycan biosynthetic process
Acav_1182	COG2912	Transglutaminase-like superfamily
Acav_1183	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Acav_1183	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Acav_1185	COG3022	response to hydroperoxide
Acav_1186	COG1530	ribonuclease E activity
Acav_1191	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Acav_1191	COG0616	signal peptide processing
Acav_1193	COG0424	maF-like protein
Acav_1194	COG1399	metal-binding, possibly nucleic acid-binding protein
Acav_1195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Acav_1196	COG0416	fatty acid biosynthetic process
Acav_1197	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Acav_1199	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_1200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Acav_1201	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Acav_1206	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Acav_1207	COG0481	GTPase activity
Acav_1208	COG0681	Belongs to the peptidase S26 family
Acav_1210	COG0571	ribonuclease III activity
Acav_1211	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Acav_1212	COG1381	Involved in DNA repair and RecF pathway recombination
Acav_1213	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Acav_1214	COG0736	holo-[acyl-carrier-protein] synthase activity
Acav_1215	COG1472	Belongs to the glycosyl hydrolase 3 family
Acav_1216	COG3064	Membrane
Acav_1218	COG2203	Gaf domain
Acav_1218	COG3706	GGDEF domain
Acav_1218	COG4251	negative regulation of phosphorylation
Acav_1218	COG5001	Diguanylate cyclase
Acav_1219	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Acav_1223	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Acav_1224	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Acav_1225	COG0438	transferase activity, transferring glycosyl groups
Acav_1227	COG0762	integral membrane protein
Acav_1228	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Acav_1229	COG0159	tryptophan synthase activity
Acav_1230	COG0133	tryptophan synthase activity
Acav_1231	COG0135	phosphoribosylanthranilate isomerase activity
Acav_1232	COG0101	tRNA pseudouridine synthase activity
Acav_1234	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Acav_1237	COG0473	3-isopropylmalate dehydrogenase activity
Acav_1238	COG0066	3-isopropylmalate dehydratase activity
Acav_1240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Acav_1242	COG0484	heat shock protein binding
Acav_1243	COG0443	Heat shock 70 kDa protein
Acav_1244	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Acav_1245	COG0360	Binds together with S18 to 16S ribosomal RNA
Acav_1247	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Acav_1248	COG0359	binds to the 23S rRNA
Acav_1249	COG0305	Participates in initiation and elongation during chromosome replication
Acav_1252	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Acav_1253	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Acav_1255	COG0436	Aminotransferase
Acav_1258	COG1763	Mo-molybdopterin cofactor biosynthetic process
Acav_1259	COG0303	'Molybdopterin
Acav_1261	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Acav_1266	COG0314	molybdopterin synthase activity
Acav_1267	COG0542	response to heat
Acav_1271	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Acav_1273	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Acav_1274	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Acav_1277	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Acav_1278	COG1185	polyribonucleotide nucleotidyltransferase activity
Acav_1280	COG0149	triose-phosphate isomerase activity
Acav_1282	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Acav_1283	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Acav_1284	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Acav_1285	COG0649	NAD binding
Acav_1286	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Acav_1287	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Acav_1288	COG1034	ATP synthesis coupled electron transport
Acav_1289	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Acav_1290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Acav_1292	COG0713	ATP synthesis coupled electron transport
Acav_1295	COG1007	ATP synthesis coupled electron transport
Acav_1298	COG1132	(ABC) transporter
Acav_1303	COG0559	Belongs to the binding-protein-dependent transport system permease family
Acav_1307	COG0463	Glycosyl transferase, family 2
Acav_1307	COG0457	Tetratricopeptide repeat
Acav_1311	COG0071	Belongs to the small heat shock protein (HSP20) family
Acav_1312	COG0577	efflux transmembrane transporter activity
Acav_1312	COG1136	(ABC) transporter
Acav_1313	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Acav_1314	COG0702	epimerase
Acav_1315	COG1733	regulation of RNA biosynthetic process
Acav_1316	COG2267	carboxylic ester hydrolase activity
Acav_1317	COG0584	glycerophosphoryl diester phosphodiesterase
Acav_1319	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Acav_1320	COG0586	Pfam SNARE associated Golgi protein
Acav_1324	COG0860	N-Acetylmuramoyl-L-alanine amidase
Acav_1325	COG0802	atpase or kinase
Acav_1326	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Acav_1329	COG0540	Belongs to the ATCase OTCase family
Acav_1332	COG4974	Belongs to the 'phage' integrase family
Acav_1333	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_1334	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Acav_1335	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Acav_1336	COG2833	Protein of unknown function (DUF455)
Acav_1338	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Acav_1340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Acav_1341	COG0148	phosphopyruvate hydratase activity
Acav_1343	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Acav_1344	COG0504	CTP synthase activity
Acav_1345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Acav_1346	COG0756	dUTP diphosphatase activity
Acav_1348	COG1047	Peptidyl-prolyl cis-trans
Acav_1349	COG2850	peptidyl-arginine hydroxylation
Acav_1351	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Acav_1352	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Acav_1353	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Acav_1354	COG2226	methyltransferase
Acav_1357	COG0187	DNA topoisomerase II activity
Acav_1358	COG0741	lytic transglycosylase activity
Acav_1360	COG0840	transmembrane signaling receptor activity
Acav_1361	COG0840	transmembrane signaling receptor activity
Acav_1362	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Acav_1368	COG2308	Evidence 4 Homologs of previously reported genes of
Acav_1372	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Acav_1374	COG4628	conserved protein (DUF2132)
Acav_1375	COG2226	methyltransferase
Acav_1378	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Acav_1379	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_1387	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Acav_1388	COG0318	PFAM AMP-dependent synthetase and ligase
Acav_1390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Acav_1391	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Acav_1402	COG4774	siderophore transport
Acav_1410	COG3634	alkyl hydroperoxide reductase activity
Acav_1416	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Acav_1419	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Acav_1424	COG0583	DNA-binding transcription factor activity
Acav_1425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Acav_1426	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Acav_1430	COG0583	DNA-binding transcription factor activity
Acav_1431	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Acav_1433	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_1434	COG4948	Mandelate Racemase Muconate Lactonizing
Acav_1443	COG0840	transmembrane signaling receptor activity
Acav_1445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Acav_1447	COG5001	Diguanylate cyclase
Acav_1447	COG3300	MHYT domain
Acav_1448	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Acav_1449	COG0405	Gamma-glutamyltransferase
Acav_1450	COG3540	Alkaline phosphatase
Acav_1451	COG0745	RESPONSE REGULATOR receiver
Acav_1451	COG3706	GGDEF domain
Acav_1452	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_1452	COG3321	synthase
Acav_1452	COG0604	alcohol dehydrogenase
Acav_1453	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Acav_1454	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Acav_1456	COG0564	pseudouridine synthase activity
Acav_1457	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Acav_1458	COG1187	pseudouridine synthase activity
Acav_1459	COG0105	UTP biosynthetic process
Acav_1460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Acav_1461	COG3063	Type IV pilus biogenesis stability protein PilW
Acav_1463	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Acav_1464	COG0124	histidyl-tRNA synthetase
Acav_1467	COG1160	GTP binding
Acav_1468	COG1923	regulation of RNA biosynthetic process
Acav_1469	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Acav_1470	COG0330	HflC and HflK could
Acav_1471	COG0330	HflC and HflK could
Acav_1472	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Acav_1473	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Acav_1474	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Acav_1475	COG1187	pseudouridine synthase activity
Acav_1483	COG3852	Histidine kinase
Acav_1486	COG0708	Exodeoxyribonuclease III
Acav_1489	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Acav_1491	COG0277	FAD linked oxidase domain protein
Acav_1493	COG1295	ribonuclease BN
Acav_1494	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Acav_1495	COG1562	ergosterol biosynthetic process
Acav_1496	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Acav_1497	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Acav_1498	COG0740	serine-type endopeptidase activity
Acav_1499	COG0544	peptidyl-prolyl cis-trans isomerase activity
Acav_1500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Acav_1508	COG0631	protein serine/threonine phosphatase activity
Acav_1511	COG2885	chlorophyll binding
Acav_1523	COG1451	nucleotide metabolic process
Acav_1524	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Acav_1525	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Acav_1526	COG2080	2 iron, 2 sulfur cluster binding
Acav_1527	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Acav_1530	COG0114	fumarate hydratase activity
Acav_1532	COG0745	RESPONSE REGULATOR receiver
Acav_1533	COG2205	protein histidine kinase activity
Acav_1534	COG2113	Glycine betaine
Acav_1535	COG4176	ABC-type proline glycine betaine transport system permease component
Acav_1536	COG4175	Glycine betaine
Acav_1539	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Acav_1541	COG4654	Cytochrome c, class I
Acav_1543	COG0129	dihydroxy-acid dehydratase activity
Acav_1547	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Acav_1548	COG1802	Transcriptional regulator
Acav_1552	COG0318	PFAM AMP-dependent synthetase and ligase
Acav_1553	COG0583	DNA-binding transcription factor activity
Acav_1554	COG1228	amidohydrolase
Acav_1560	COG0589	response to stress
Acav_1561	COG2217	Heavy metal translocating P-type atpase
Acav_1563	COG3278	Belongs to the heme-copper respiratory oxidase family
Acav_1570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Acav_1571	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Acav_1573	COG3437	response regulator, receiver
Acav_1577	COG4206	TonB-dependent receptor
Acav_1578	COG1797	cobyrinic acid a,c-diamide synthase activity
Acav_1581	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Acav_1582	COG1121	(ABC) transporter
Acav_1583	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Acav_1584	COG0778	Nitroreductase
Acav_1589	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_1590	COG1492	cobalamin metabolic process
Acav_1591	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Acav_1596	COG1176	ABC-type spermidine putrescine transport system, permease component I
Acav_1597	COG3833	ABC-type maltose transport systems, permease component
Acav_1601	COG0477	Major facilitator Superfamily
Acav_1604	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Acav_1605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acav_1607	COG0667	Aldo Keto reductase
Acav_1609	COG0513	Belongs to the DEAD box helicase family
Acav_1614	COG1959	2 iron, 2 sulfur cluster binding
Acav_1615	COG3386	PFAM SMP-30 Gluconolaconase
Acav_1620	COG0583	DNA-binding transcription factor activity
Acav_1623	COG0560	Phosphoserine phosphatase
Acav_1625	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Acav_1627	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Acav_1628	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Acav_1628	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Acav_1629	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Acav_1629	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Acav_1630	COG2205	protein histidine kinase activity
Acav_1631	COG0745	RESPONSE REGULATOR receiver
Acav_1633	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_1635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Acav_1642	COG0840	transmembrane signaling receptor activity
Acav_1649	COG0693	protein deglycase activity
Acav_1651	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Acav_1653	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Acav_1654	COG2721	sulfolactate sulfo-lyase activity
Acav_1655	COG3254	rhamnose metabolic process
Acav_1656	COG0246	Mannitol dehydrogenase
Acav_1657	COG1063	alcohol dehydrogenase
Acav_1661	COG1172	Belongs to the binding-protein-dependent transport system permease family
Acav_1662	COG1129	ABC transporter
Acav_1665	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_1666	COG0179	Fumarylacetoacetate (FAA) hydrolase
Acav_1670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Acav_1672	COG1914	H( )-stimulated, divalent metal cation uptake system
Acav_1678	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Acav_1681	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Acav_1682	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Acav_1686	COG1446	asparaginase
Acav_1687	COG4172	Belongs to the ABC transporter superfamily
Acav_1689	COG0601	transmembrane transport
Acav_1690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Acav_1694	COG0322	excinuclease ABC activity
Acav_1696	COG0776	regulation of translation
Acav_1697	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Acav_1698	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_1699	COG0165	Argininosuccinate lyase
Acav_1700	COG0583	DNA-binding transcription factor activity
Acav_1702	COG0024	Methionine aminopeptidase
Acav_1704	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_1705	COG0028	Belongs to the TPP enzyme family
Acav_1706	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_1710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Acav_1712	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Acav_1720	COG3038	cytochrome b561
Acav_1721	COG1012	belongs to the aldehyde dehydrogenase family
Acav_1724	COG0840	transmembrane signaling receptor activity
Acav_1725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Acav_1730	COG4651	solute:proton antiporter activity
Acav_1730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Acav_1732	COG0513	Belongs to the DEAD box helicase family
Acav_1733	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Acav_1734	COG0488	(ABC) transporter
Acav_1737	COG3191	aminopeptidase activity
Acav_1744	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Acav_1747	COG2132	Multicopper oxidase
Acav_1752	COG2217	Heavy metal translocating P-type atpase
Acav_1753	COG0789	Transcriptional regulator
Acav_1758	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Acav_1758	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Acav_1759	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acav_1760	COG0052	Belongs to the universal ribosomal protein uS2 family
Acav_1761	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Acav_1762	COG0528	UMP kinase activity
Acav_1763	COG0233	cytoplasmic translational termination
Acav_1764	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Acav_1765	COG0575	Belongs to the CDS family
Acav_1766	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Acav_1767	COG0750	zinc metalloprotease
Acav_1770	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Acav_1771	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Acav_1772	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Acav_1773	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Acav_1774	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Acav_1775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Acav_1778	COG4774	siderophore transport
Acav_1781	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Acav_1782	COG0308	aminopeptidase N
Acav_1788	COG0667	Aldo Keto reductase
Acav_1789	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Acav_1790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Acav_1792	COG3577	Aspartyl protease
Acav_1793	COG1666	GTP binding
Acav_1795	COG0137	argininosuccinate synthase activity
Acav_1796	COG3123	guanosine phosphorylase activity
Acav_1798	COG1393	Belongs to the ArsC family
Acav_1799	COG0285	dihydrofolate synthase activity
Acav_1801	COG1286	toxin biosynthetic process
Acav_1804	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Acav_1806	COG2814	Major facilitator Superfamily
Acav_1807	COG2814	Major facilitator Superfamily
Acav_1810	COG2183	response to ionizing radiation
Acav_1813	COG1454	alcohol dehydrogenase
Acav_1818	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Acav_1819	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Acav_1822	COG0084	hydrolase, TatD family'
Acav_1824	COG1132	(ABC) transporter
Acav_1825	COG0823	Involved in the tonB-independent uptake of proteins
Acav_1828	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Acav_1832	COG2963	transposase activity
Acav_1835	COG2423	ornithine cyclodeaminase activity
Acav_1843	COG5001	Diguanylate cyclase
Acav_1843	COG4251	negative regulation of phosphorylation
Acav_1843	COG3706	GGDEF domain
Acav_1843	COG2203	Gaf domain
Acav_1850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Acav_1850	COG2010	Cytochrome c
Acav_1852	COG0779	Required for maturation of 30S ribosomal subunits
Acav_1853	COG2251	uridine kinase activity
Acav_1853	COG0195	Participates in both transcription termination and antitermination
Acav_1854	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Acav_1855	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Acav_1856	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Acav_1858	COG1253	flavin adenine dinucleotide binding
Acav_1859	COG1024	Enoyl-CoA hydratase
Acav_1863	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Acav_1864	COG2867	negative regulation of translational initiation
Acav_1865	COG2914	Belongs to the UPF0125 (RnfH) family
Acav_1871	COG0519	Catalyzes the synthesis of GMP from XMP
Acav_1871	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Acav_1872	COG0582	viral genome integration into host DNA
Acav_1883	COG0583	DNA-binding transcription factor activity
Acav_1885	COG1566	PFAM secretion protein HlyD family protein
Acav_1887	COG1289	transmembrane transporter activity
Acav_1892	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Acav_1893	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_1894	COG4221	oxidoreductase activity
Acav_1896	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_1900	COG2207	Transcriptional regulator
Acav_1904	COG1309	transcriptional regulator
Acav_1905	COG3501	Rhs element vgr protein
Acav_1910	COG2226	methyltransferase
Acav_1913	COG5002	protein histidine kinase activity
Acav_1914	COG0494	nUDIX hydrolase
Acav_1919	COG3706	GGDEF domain
Acav_1922	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_1924	COG0625	glutathione transferase activity
Acav_1928	COG4774	siderophore transport
Acav_1929	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Acav_1931	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Acav_1933	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Acav_1933	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Acav_1933	COG0506	proline dehydrogenase activity
Acav_1937	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Acav_1939	COG0670	Belongs to the BI1 family
Acav_1940	COG3193	protein, possibly involved in utilization of glycolate and propanediol
Acav_1948	COG0405	Gamma-glutamyltransferase
Acav_1949	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Acav_1951	COG1322	Protein conserved in bacteria
Acav_1955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Acav_1962	COG2212	antiporter activity
Acav_1964	COG0651	ATP synthesis coupled electron transport
Acav_1965	COG1006	Multisubunit Na H antiporter MnhC subunit
Acav_1966	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Acav_1966	COG2111	Na H antiporter
Acav_1967	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Acav_1969	COG0776	regulation of translation
Acav_1971	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Acav_1972	COG0287	Prephenate dehydrogenase
Acav_1973	COG0077	Prephenate dehydratase
Acav_1973	COG1605	Chorismate mutase
Acav_1974	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Acav_1977	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Acav_1981	COG0745	RESPONSE REGULATOR receiver
Acav_1985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Acav_1988	COG0583	DNA-binding transcription factor activity
Acav_1991	COG1982	Orn Lys Arg decarboxylase major
Acav_1992	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Acav_1994	COG4166	transmembrane transport
Acav_1995	COG4174	ABC transporter (Permease)
Acav_1996	COG4239	(ABC) transporter, permease
Acav_1997	COG4172	Belongs to the ABC transporter superfamily
Acav_1998	COG5001	Diguanylate cyclase
Acav_1998	COG3447	MASE1 domain protein
Acav_1998	COG5002	protein histidine kinase activity
Acav_1999	COG0628	permease
Acav_2000	COG0567	Dehydrogenase, E1 component
Acav_2001	COG0508	dehydrogenase complex catalyzes the overall conversion of
Acav_2002	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Acav_2003	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Acav_2006	COG1199	ATP-dependent helicase activity
Acav_2009	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Acav_2010	COG0542	response to heat
Acav_2013	COG2951	lytic endotransglycosylase activity
Acav_2014	COG2925	Exonuclease
Acav_2016	COG3284	Transcriptional regulator
Acav_2020	COG1012	belongs to the aldehyde dehydrogenase family
Acav_2021	COG0484	heat shock protein binding
Acav_2030	COG0402	S-adenosylhomocysteine deaminase activity
Acav_2037	COG1744	ABC transporter substrate-binding protein PnrA-like
Acav_2048	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Acav_2052	COG0583	DNA-binding transcription factor activity
Acav_2053	COG0625	glutathione transferase activity
Acav_2054	COG0433	COG0433 Predicted ATPase
Acav_2055	COG0217	transcriptional regulatory protein
Acav_2056	COG0151	Belongs to the GarS family
Acav_2057	COG0408	coproporphyrinogen oxidase activity
Acav_2058	COG0799	negative regulation of ribosome biogenesis
Acav_2059	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Acav_2061	COG0424	maF-like protein
Acav_2062	COG1530	ribonuclease E activity
Acav_2072	COG2205	protein histidine kinase activity
Acav_2073	COG0596	Alpha beta hydrolase
Acav_2076	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_2078	COG1024	Enoyl-CoA hydratase
Acav_2079	COG1960	acyl-CoA dehydrogenase activity
Acav_2081	COG0683	leucine binding
Acav_2082	COG0559	Belongs to the binding-protein-dependent transport system permease family
Acav_2088	COG0436	Aminotransferase
Acav_2089	COG0583	DNA-binding transcription factor activity
Acav_2093	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Acav_2098	COG0372	Belongs to the citrate synthase family
Acav_2099	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Acav_2101	COG0318	PFAM AMP-dependent synthetase and ligase
Acav_2104	COG0589	response to stress
Acav_2105	COG3039	Transposase
Acav_2107	COG3158	transport of potassium into the cell
Acav_2109	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_2110	COG0564	pseudouridine synthase activity
Acav_2113	COG0789	Transcriptional regulator
Acav_2114	COG0545	Peptidyl-prolyl cis-trans isomerase
Acav_2115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Acav_2115	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Acav_2116	COG0509	glycine decarboxylation via glycine cleavage system
Acav_2117	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Acav_2120	COG4120	Belongs to the binding-protein-dependent transport system permease family
Acav_2126	COG0367	asparagine synthase
Acav_2127	COG1012	belongs to the aldehyde dehydrogenase family
Acav_2128	COG0730	response to heat
Acav_2133	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_2147	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Acav_2148	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Acav_2153	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Acav_2155	COG1252	NADH dehydrogenase
Acav_2160	COG0835	chemotaxis
Acav_2162	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Acav_2162	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acav_2163	COG0347	Belongs to the P(II) protein family
Acav_2165	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Acav_2169	COG1595	DNA-templated transcription, initiation
Acav_2171	COG0028	Belongs to the TPP enzyme family
Acav_2172	COG0440	acetolactate synthase activity
Acav_2173	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Acav_2174	COG1183	phosphatidylcholine synthase activity
Acav_2175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Acav_2177	COG1414	Transcriptional regulator
Acav_2178	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Acav_2179	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Acav_2180	COG2832	Protein of unknown function (DUF454)
Acav_2181	COG0242	peptide deformylase activity
Acav_2182	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Acav_2183	COG0024	Methionine aminopeptidase
Acav_2184	COG0047	phosphoribosylformylglycinamidine synthase activity
Acav_2184	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Acav_2187	COG3300	MHYT domain
Acav_2187	COG5001	Diguanylate cyclase
Acav_2188	COG2354	Protein conserved in bacteria
Acav_2189	COG3047	cAMP biosynthetic process
Acav_2192	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Acav_2193	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Acav_2197	COG0826	peptidase U32
Acav_2201	COG0590	tRNA wobble adenosine to inosine editing
Acav_2202	COG1619	proteins homologs of microcin C7 resistance protein MccF
Acav_2205	COG1960	acyl-CoA dehydrogenase activity
Acav_2207	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Acav_2208	COG1024	Enoyl-CoA hydratase
Acav_2209	COG1250	3-hydroxyacyl-CoA dehydrogenase
Acav_2212	COG2022	thiamine diphosphate biosynthetic process
Acav_2215	COG0351	phosphomethylpyrimidine kinase
Acav_2224	COG0492	ferredoxin-NADP+ reductase activity
Acav_2225	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Acav_2226	COG0529	Catalyzes the synthesis of activated sulfate
Acav_2226	COG2895	sulfate adenylyltransferase (ATP) activity
Acav_2230	COG0730	response to heat
Acav_2233	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acav_2233	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Acav_2234	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Acav_2236	COG0431	NADPH-dependent FMN reductase
Acav_2237	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Acav_2239	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Acav_2241	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Acav_2242	COG1116	anion transmembrane transporter activity
Acav_2244	COG0583	DNA-binding transcription factor activity
Acav_2248	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Acav_2249	COG3706	GGDEF domain
Acav_2250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Acav_2251	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Acav_2252	COG0493	'glutamate synthase
Acav_2252	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Acav_2253	COG0583	DNA-binding transcription factor activity
Acav_2254	COG1741	Belongs to the pirin family
Acav_2256	COG1741	Belongs to the pirin family
Acav_2258	COG0455	bacterial-type flagellum organization
Acav_2259	COG0745	RESPONSE REGULATOR receiver
Acav_2259	COG3706	GGDEF domain
Acav_2265	COG4181	ATPase activity
Acav_2266	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Acav_2267	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Acav_2268	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Acav_2269	COG0667	Aldo Keto reductase
Acav_2273	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Acav_2281	COG4178	(ABC) transporter
Acav_2282	COG4774	siderophore transport
Acav_2284	COG0642	Histidine kinase
Acav_2286	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_2296	COG5002	protein histidine kinase activity
Acav_2297	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Acav_2298	COG1011	Hydrolase
Acav_2299	COG2267	carboxylic ester hydrolase activity
Acav_2301	COG0517	IMP dehydrogenase activity
Acav_2301	COG1125	glycine betaine transport
Acav_2302	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Acav_2304	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Acav_2305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Acav_2306	COG0741	lytic transglycosylase activity
Acav_2309	COG0557	exoribonuclease II activity
Acav_2310	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_2312	COG0297	glycogen (starch) synthase activity
Acav_2316	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Acav_2321	COG2205	protein histidine kinase activity
Acav_2322	COG2205	protein histidine kinase activity
Acav_2324	COG2172	sigma factor antagonist activity
Acav_2325	COG1366	Belongs to the anti-sigma-factor antagonist family
Acav_2326	COG1366	Belongs to the anti-sigma-factor antagonist family
Acav_2328	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Acav_2330	COG2188	Transcriptional regulator
Acav_2331	COG2986	histidine ammonia-lyase
Acav_2332	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Acav_2335	COG1228	amidohydrolase
Acav_2338	COG5006	permease, DMT superfamily
Acav_2341	COG0688	phosphatidylethanolamine metabolic process
Acav_2342	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Acav_2345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Acav_2347	COG2917	probably involved in intracellular septation
Acav_2348	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Acav_2349	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Acav_2350	COG0318	PFAM AMP-dependent synthetase and ligase
Acav_2352	COG0559	Belongs to the binding-protein-dependent transport system permease family
Acav_2354	COG0411	ABC transporter
Acav_2359	COG3706	GGDEF domain
Acav_2362	COG1250	3-hydroxyacyl-CoA dehydrogenase
Acav_2362	COG1024	Enoyl-CoA hydratase
Acav_2363	COG0183	Belongs to the thiolase family
Acav_2364	COG2050	protein possibly involved in aromatic compounds catabolism
Acav_2365	COG1960	acyl-CoA dehydrogenase activity
Acav_2368	COG2130	NADP-dependent
Acav_2369	COG2153	protein acetylation
Acav_2373	COG1840	ABC-type Fe3 transport system, periplasmic component
Acav_2375	COG0697	spore germination
Acav_2376	COG1522	sequence-specific DNA binding
Acav_2379	COG2224	Isocitrate lyase
Acav_2380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Acav_2381	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Acav_2382	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Acav_2383	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Acav_2384	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Acav_2385	COG0072	phenylalanine-tRNA ligase activity
Acav_2385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acav_2386	COG0776	regulation of translation
Acav_2387	COG0789	Transcriptional regulator
Acav_2391	COG1132	(ABC) transporter
Acav_2392	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Acav_2394	COG1742	UPF0060 membrane protein
Acav_2396	COG1196	nuclear chromosome segregation
Acav_2398	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Acav_2399	COG3501	Rhs element vgr protein
Acav_2401	COG3209	COG3209 Rhs family protein
Acav_2411	COG0791	NLP P60 protein
Acav_2412	COG2133	pyrroloquinoline quinone binding
Acav_2415	COG0318	PFAM AMP-dependent synthetase and ligase
Acav_2417	COG1902	pentaerythritol trinitrate reductase activity
Acav_2417	COG0446	pyridine nucleotide-disulphide oxidoreductase
Acav_2422	COG2169	Transcriptional regulator
Acav_2427	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Acav_2434	COG1042	CoA-binding domain protein
Acav_2434	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Acav_2434	COG0045	succinate-CoA ligase (ADP-forming) activity
Acav_2438	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Acav_2439	COG1309	transcriptional regulator
Acav_2440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Acav_2442	COG0577	efflux transmembrane transporter activity
Acav_2442	COG1136	(ABC) transporter
Acav_2447	COG4206	TonB-dependent receptor
Acav_2448	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acav_2450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acav_2452	COG0793	Belongs to the peptidase S41A family
Acav_2455	COG0259	pyridoxamine-phosphate oxidase activity
Acav_2462	COG1609	Transcriptional regulator
Acav_2463	COG3265	gluconokinase activity
Acav_2464	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Acav_2465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Acav_2466	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Acav_2468	COG0800	Aldolase
Acav_2470	COG0346	lactoylglutathione lyase activity
Acav_2471	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_2477	COG0583	DNA-binding transcription factor activity
Acav_2479	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Acav_2490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acav_2492	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Acav_2493	COG4166	transmembrane transport
Acav_2495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Acav_2500	COG0583	DNA-binding transcription factor activity
Acav_2503	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Acav_2509	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Acav_2511	COG1696	Membrane protein involved in D-alanine export
Acav_2515	COG1215	transferase activity, transferring glycosyl groups
Acav_2517	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Acav_2520	COG0564	pseudouridine synthase activity
Acav_2521	COG2982	Protein involved in outer membrane biogenesis
Acav_2522	COG0587	DNA-directed DNA polymerase activity
Acav_2525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Acav_2526	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Acav_2531	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Acav_2542	COG0644	oxidoreductase
Acav_2545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Acav_2546	COG0746	molybdenum cofactor guanylyltransferase activity
Acav_2548	COG0303	'Molybdopterin
Acav_2550	COG0328	RNA-DNA hybrid ribonuclease activity
Acav_2552	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Acav_2553	COG0741	lytic transglycosylase activity
Acav_2553	COG1388	LysM domain
Acav_2557	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Acav_2558	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Acav_2559	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Acav_2560	COG0840	transmembrane signaling receptor activity
Acav_2561	COG2081	HI0933 family
Acav_2562	COG1074	ATP-dependent DNA helicase activity
Acav_2565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Acav_2566	COG0419	ATPase involved in DNA repair
Acav_2567	COG0420	3'-5' exonuclease activity
Acav_2568	COG0254	rRNA binding
Acav_2570	COG0534	Mate efflux family protein
Acav_2573	COG0704	Plays a role in the regulation of phosphate uptake
Acav_2574	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Acav_2575	COG0581	inorganic phosphate transmembrane transporter activity
Acav_2576	COG0573	inorganic phosphate transmembrane transporter activity
Acav_2577	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Acav_2578	COG0248	Ppx GppA phosphatase
Acav_2584	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Acav_2586	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acav_2587	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Acav_2588	COG1534	Rna-binding protein
Acav_2591	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Acav_2592	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Acav_2593	COG0505	Belongs to the CarA family
Acav_2595	COG1113	amino acid transport
Acav_2601	COG1960	acyl-CoA dehydrogenase activity
Acav_2604	COG2032	superoxide dismutase activity
Acav_2605	COG4772	TonB-dependent receptor
Acav_2608	COG2721	sulfolactate sulfo-lyase activity
Acav_2611	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Acav_2613	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Acav_2615	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_2616	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Acav_2623	COG2814	Major facilitator Superfamily
Acav_2625	COG0840	transmembrane signaling receptor activity
Acav_2631	COG0745	RESPONSE REGULATOR receiver
Acav_2640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Acav_2641	COG1570	exodeoxyribonuclease VII activity
Acav_2642	COG0811	peptide transport
Acav_2643	COG0848	biopolymer transport protein
Acav_2644	COG1663	tetraacyldisaccharide 4'-kinase activity
Acav_2645	COG2835	tetraacyldisaccharide 4'-kinase activity
Acav_2646	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Acav_2647	COG0563	adenylate kinase activity
Acav_2648	COG0252	asparaginase activity
Acav_2649	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Acav_2651	COG1643	Atp-dependent helicase
Acav_2653	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acav_2654	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Acav_2654	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Acav_2658	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Acav_2659	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Acav_2660	COG4208	sulfate ABC transporter
Acav_2661	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Acav_2662	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Acav_2666	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Acav_2669	COG0840	transmembrane signaling receptor activity
Acav_2673	COG2011	ABC-type metal ion transport system permease component
Acav_2674	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Acav_2676	COG2814	Major facilitator Superfamily
Acav_2677	COG0583	DNA-binding transcription factor activity
Acav_2681	COG1538	Outer membrane efflux protein
Acav_2682	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Acav_2685	COG5002	protein histidine kinase activity
Acav_2687	COG0583	DNA-binding transcription factor activity
Acav_2694	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Acav_2697	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Acav_2698	COG1737	Transcriptional regulator
Acav_2701	COG0439	Biotin carboxylase
Acav_2706	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Acav_2707	COG1703	isobutyryl-CoA mutase activity
Acav_2710	COG1802	Transcriptional regulator
Acav_2720	COG0840	transmembrane signaling receptor activity
Acav_2721	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Acav_2725	COG2878	Part of a membrane complex involved in electron transport
Acav_2726	COG0840	transmembrane signaling receptor activity
Acav_2728	COG2171	N-acyltransferase activity
Acav_2729	COG2805	Type II/IV secretion system protein
Acav_2730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acav_2731	COG2890	protein-(glutamine-N5) methyltransferase activity
Acav_2733	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_2734	COG0183	Belongs to the thiolase family
Acav_2735	COG3243	poly(R)-hydroxyalkanoic acid synthase
Acav_2741	COG0515	serine threonine protein kinase
Acav_2745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Acav_2747	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Acav_2751	COG2755	lipolytic protein G-D-S-L family
Acav_2751	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Acav_2752	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Acav_2753	COG0508	dehydrogenase complex catalyzes the overall conversion of
Acav_2754	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Acav_2756	COG4566	intracellular signal transduction
Acav_2757	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Acav_2760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Acav_2761	COG0167	dihydroorotate dehydrogenase activity
Acav_2765	COG0579	oxidoreductase
Acav_2768	COG0633	Ferredoxin
Acav_2769	COG0443	Heat shock 70 kDa protein
Acav_2770	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Acav_2772	COG0822	iron-sulfur transferase activity
Acav_2773	COG1104	cysteine desulfurase activity
Acav_2774	COG1959	2 iron, 2 sulfur cluster binding
Acav_2777	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Acav_2780	COG0840	transmembrane signaling receptor activity
Acav_2782	COG1739	Uncharacterized protein family UPF0029
Acav_2786	COG0154	amidase activity
Acav_2787	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_2788	COG3048	D-serine ammonia-lyase activity
Acav_2792	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Acav_2806	COG0527	aspartate kinase activity
Acav_2807	COG0037	tRNA processing
Acav_2810	COG0215	cysteine-tRNA ligase activity
Acav_2815	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Acav_2824	COG1522	sequence-specific DNA binding
Acav_2828	COG3384	dioxygenase
Acav_2831	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Acav_2833	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Acav_2834	COG1950	PFAM Membrane protein of
Acav_2837	COG0765	amino acid transport
Acav_2838	COG0765	amino acid transport
Acav_2839	COG1126	abc transporter atp-binding protein
Acav_2844	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_2845	COG0583	DNA-binding transcription factor activity
Acav_2853	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Acav_2859	COG0840	transmembrane signaling receptor activity
Acav_2865	COG0564	pseudouridine synthase activity
Acav_2866	COG1285	pathogenesis
Acav_2869	COG2814	Major facilitator Superfamily
Acav_2873	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Acav_2875	COG5002	protein histidine kinase activity
Acav_2877	COG0028	Belongs to the TPP enzyme family
Acav_2878	COG2918	glutathione biosynthetic process
Acav_2881	COG3386	PFAM SMP-30 Gluconolaconase
Acav_2885	COG1879	ABC-type sugar transport system periplasmic component
Acav_2886	COG4213	ABC transporter substrate-binding protein
Acav_2888	COG4214	carbohydrate transport
Acav_2890	COG1172	Belongs to the binding-protein-dependent transport system permease family
Acav_2891	COG1172	Belongs to the binding-protein-dependent transport system permease family
Acav_2894	COG3734	2-keto-3-deoxy-galactonokinase
Acav_2895	COG0800	Aldolase
Acav_2896	COG4948	Mandelate Racemase Muconate Lactonizing
Acav_2897	COG1289	transmembrane transporter activity
Acav_2899	COG0840	transmembrane signaling receptor activity
Acav_2901	COG2201	protein-glutamate methylesterase activity
Acav_2902	COG0745	RESPONSE REGULATOR receiver
Acav_2904	COG2205	protein histidine kinase activity
Acav_2904	COG2202	Pas domain
Acav_2906	COG0633	Ferredoxin
Acav_2909	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Acav_2910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Acav_2911	COG0436	Aminotransferase
Acav_2912	COG0824	Thioesterase
Acav_2918	COG0477	Major facilitator Superfamily
Acav_2919	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Acav_2920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Acav_2921	COG1845	cytochrome c oxidase, subunit III
Acav_2922	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Acav_2925	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Acav_2931	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
Acav_2932	COG1049	propionate catabolic process, 2-methylcitrate cycle
Acav_2935	COG4106	trans-aconitate 2-methyltransferase activity
Acav_2936	COG0039	L-malate dehydrogenase activity
Acav_2937	COG2188	Transcriptional regulator
Acav_2940	COG1053	succinate dehydrogenase
Acav_2941	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Acav_2942	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Acav_2943	COG0372	Belongs to the citrate synthase family
Acav_2945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Acav_2946	COG4977	sequence-specific DNA binding
Acav_2948	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Acav_2949	COG2194	sulfuric ester hydrolase activity
Acav_2951	COG0840	transmembrane signaling receptor activity
Acav_2953	COG0473	3-isopropylmalate dehydrogenase activity
Acav_2955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Acav_2956	COG0601	transmembrane transport
Acav_2958	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acav_2963	COG1522	sequence-specific DNA binding
Acav_2972	COG1960	acyl-CoA dehydrogenase activity
Acav_2975	COG3264	Mechanosensitive ion channel
Acav_2975	COG1511	domain protein
Acav_2977	COG1024	Enoyl-CoA hydratase
Acav_2978	COG0123	including yeast histone deacetylase and acetoin utilization protein
Acav_2979	COG0714	Associated with various cellular activities
Acav_2982	COG2951	lytic endotransglycosylase activity
Acav_2985	COG3268	Saccharopine dehydrogenase
Acav_2986	COG0318	PFAM AMP-dependent synthetase and ligase
Acav_2993	COG0683	leucine binding
Acav_2996	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Acav_2997	COG0683	leucine binding
Acav_3000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Acav_3001	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Acav_3002	COG1116	anion transmembrane transporter activity
Acav_3003	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Acav_3007	COG2223	nitrite transmembrane transporter activity
Acav_3008	COG0583	DNA-binding transcription factor activity
Acav_3009	COG3971	2-oxopent-4-enoate hydratase activity
Acav_3011	COG0277	FAD linked oxidase domain protein
Acav_3012	COG1012	belongs to the aldehyde dehydrogenase family
Acav_3015	COG0179	Fumarylacetoacetate (FAA) hydrolase
Acav_3016	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Acav_3029	COG0840	transmembrane signaling receptor activity
Acav_3030	COG0643	Histidine kinase
Acav_3030	COG2198	Histidine kinase
Acav_3031	COG4221	oxidoreductase activity
Acav_3035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Acav_3036	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Acav_3037	COG0516	GMP reductase activity
Acav_3037	COG0517	IMP dehydrogenase activity
Acav_3038	COG0840	transmembrane signaling receptor activity
Acav_3040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Acav_3041	COG1538	Outer membrane efflux protein
Acav_3042	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Acav_3043	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Acav_3047	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Acav_3049	COG0243	molybdopterin cofactor binding
Acav_3053	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Acav_3053	COG5297	Belongs to the glycosyl hydrolase family 6
Acav_3055	COG1607	acyl-coa hydrolase
Acav_3056	COG0288	reversible hydration of carbon dioxide
Acav_3059	COG2081	HI0933 family
Acav_3060	COG0640	Transcriptional regulator
Acav_3064	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Acav_3065	COG1610	YqeY-like protein
Acav_3066	COG0625	glutathione transferase activity
Acav_3068	COG0583	DNA-binding transcription factor activity
Acav_3069	COG0473	3-isopropylmalate dehydrogenase activity
Acav_3070	COG1752	Esterase of the alpha-beta hydrolase superfamily
Acav_3071	COG0477	Major facilitator Superfamily
Acav_3073	COG0583	DNA-binding transcription factor activity
Acav_3079	COG2721	sulfolactate sulfo-lyase activity
Acav_3084	COG0312	modulator of DNA gyrase
Acav_3085	COG3028	Belongs to the UPF0307 family
Acav_3086	COG0521	Mo-molybdopterin cofactor biosynthetic process
Acav_3088	COG1045	serine acetyltransferase
Acav_3090	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Acav_3091	COG4555	ABC transporter
Acav_3095	COG3437	response regulator, receiver
Acav_3096	COG5002	protein histidine kinase activity
Acav_3096	COG2205	protein histidine kinase activity
Acav_3096	COG0784	Response regulator, receiver
Acav_3098	COG2079	MmgE PrpD family protein
Acav_3099	COG0045	succinate-CoA ligase (ADP-forming) activity
Acav_3099	COG1042	CoA-binding domain protein
Acav_3099	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Acav_3100	COG1024	Enoyl-CoA hydratase
Acav_3104	COG5001	Diguanylate cyclase
Acav_3105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Acav_3106	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Acav_3110	COG3209	COG3209 Rhs family protein
Acav_3111	COG3501	Rhs element vgr protein
Acav_3116	COG1968	undecaprenyl-diphosphatase activity
Acav_3122	COG3275	phosphorelay sensor kinase activity
Acav_3124	COG1280	lysine exporter protein (LysE YggA)
Acav_3126	COG4133	protoheme IX ABC transporter activity
Acav_3128	COG2005	Transcriptional regulator
Acav_3128	COG3585	molybdate ion transport
Acav_3129	COG3209	COG3209 Rhs family protein
Acav_3132	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Acav_3134	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Acav_3135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Acav_3136	COG0366	Alpha amylase catalytic
Acav_3137	COG0366	Alpha amylase catalytic
Acav_3138	COG0668	transmembrane transport
Acav_3143	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Acav_3144	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Acav_3146	COG1722	exodeoxyribonuclease VII activity
Acav_3150	COG1464	Belongs to the NlpA lipoprotein family
Acav_3151	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Acav_3152	COG2011	ABC-type metal ion transport system permease component
Acav_3160	COG0628	permease
Acav_3161	COG1289	transmembrane transporter activity
Acav_3162	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Acav_3163	COG0181	hydroxymethylbilane synthase activity
Acav_3167	COG0488	(ABC) transporter
Acav_3171	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Acav_3172	COG0425	Belongs to the sulfur carrier protein TusA family
Acav_3180	COG0583	DNA-binding transcription factor activity
Acav_3181	COG1960	acyl-CoA dehydrogenase activity
Acav_3182	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Acav_3189	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Acav_3190	COG0617	tRNA 3'-terminal CCA addition
Acav_3192	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Acav_3193	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Acav_3198	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Acav_3203	COG1304	FMN binding
Acav_3206	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Acav_3213	COG2814	Major facilitator Superfamily
Acav_3216	COG0165	Argininosuccinate lyase
Acav_3217	COG3275	phosphorelay sensor kinase activity
Acav_3220	COG0165	Argininosuccinate lyase
Acav_3222	COG0412	Dienelactone hydrolase
Acav_3228	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Acav_3229	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acav_3230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acav_3238	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Acav_3250	COG0210	DNA helicase
Acav_3255	COG0516	GMP reductase activity
Acav_3257	COG1309	transcriptional regulator
Acav_3259	COG2204	response regulator
Acav_3260	COG5002	protein histidine kinase activity
Acav_3261	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Acav_3264	COG2814	Major facilitator Superfamily
Acav_3265	COG5002	protein histidine kinase activity
Acav_3265	COG5001	Diguanylate cyclase
Acav_3265	COG3447	MASE1 domain protein
Acav_3266	COG0513	Belongs to the DEAD box helicase family
Acav_3267	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Acav_3268	COG0501	Belongs to the peptidase M48B family
Acav_3269	COG2154	pterin-4-alpha-carbinolamine dehydratase
Acav_3270	COG1162	GTPase activity
Acav_3271	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Acav_3273	COG0335	large ribosomal subunit rRNA binding
Acav_3274	COG0336	Belongs to the RNA methyltransferase TrmD family
Acav_3275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Acav_3276	COG0228	four-way junction DNA binding
Acav_3279	COG0306	phosphate transporter
Acav_3280	COG1392	Phosphate transport regulator
Acav_3283	COG0411	ABC transporter
Acav_3285	COG0559	Belongs to the binding-protein-dependent transport system permease family
Acav_3286	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Acav_3287	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Acav_3288	COG1573	uracil-dna glycosylase
Acav_3290	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Acav_3291	COG1674	ftsk spoiiie
Acav_3292	COG0492	ferredoxin-NADP+ reductase activity
Acav_3293	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Acav_3294	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Acav_3295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acav_3298	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Acav_3298	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Acav_3299	COG3866	Pectate lyase
Acav_3301	COG2205	protein histidine kinase activity
Acav_3305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Acav_3306	COG3132	Protein of unknown function, DUF480
Acav_3307	COG1960	acyl-CoA dehydrogenase activity
Acav_3311	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Acav_3312	COG0840	transmembrane signaling receptor activity
Acav_3313	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Acav_3315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Acav_3319	COG0196	riboflavin kinase activity
Acav_3321	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Acav_3325	COG4149	molybdate abc transporter
Acav_3326	COG1177	transmembrane transport
Acav_3328	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Acav_3330	COG1283	sodium-dependent phosphate transmembrane transporter activity
Acav_3333	COG0583	DNA-binding transcription factor activity
Acav_3335	COG1064	alcohol dehydrogenase
Acav_3340	COG0179	Fumarylacetoacetate (FAA) hydrolase
Acav_3345	COG2814	Major facilitator Superfamily
Acav_3350	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Acav_3353	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_3356	COG0697	spore germination
Acav_3364	COG3209	COG3209 Rhs family protein
Acav_3369	COG3501	Rhs element vgr protein
Acav_3375	COG2814	Major facilitator Superfamily
Acav_3383	COG0559	Belongs to the binding-protein-dependent transport system permease family
Acav_3385	COG1301	dicarboxylic acid transport
Acav_3386	COG5599	Phosphatase
Acav_3388	COG1522	sequence-specific DNA binding
Acav_3393	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_3400	COG4770	biotin carboxylase activity
Acav_3401	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Acav_3402	COG4336	lyase activity
Acav_3403	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Acav_3410	COG1304	FMN binding
Acav_3411	COG2186	Transcriptional regulator
Acav_3412	COG1620	l-lactate permease
Acav_3416	COG5001	Diguanylate cyclase
Acav_3421	COG0831	urea catabolic process
Acav_3423	COG0832	Belongs to the urease beta subunit family
Acav_3424	COG0804	urea catabolic process
Acav_3426	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Acav_3427	COG0830	nickel cation binding
Acav_3428	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Acav_3436	COG4172	Belongs to the ABC transporter superfamily
Acav_3439	COG0747	negative chemotaxis
Acav_3445	COG2249	NAD(P)H dehydrogenase (quinone) activity
Acav_3447	COG1063	alcohol dehydrogenase
Acav_3449	COG3284	Transcriptional regulator
Acav_3451	COG0840	transmembrane signaling receptor activity
Acav_3452	COG0745	RESPONSE REGULATOR receiver
Acav_3457	COG0835	chemotaxis
Acav_3458	COG2202	Pas domain
Acav_3458	COG2200	EAL domain
Acav_3458	COG2199	diguanylate cyclase activity
Acav_3459	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Acav_3460	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Acav_3462	COG4969	Belongs to the N-Me-Phe pilin family
Acav_3463	COG4968	Prepilin-type N-terminal cleavage methylation domain
Acav_3468	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Acav_3468	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Acav_3475	COG4191	Histidine kinase
Acav_3475	COG0784	Response regulator, receiver
Acav_3476	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Acav_3481	COG1595	DNA-templated transcription, initiation
Acav_3484	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Acav_3485	COG4221	oxidoreductase activity
Acav_3488	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Acav_3489	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Acav_3493	COG1561	YicC-like family, N-terminal region
Acav_3494	COG0194	GDP metabolic process
Acav_3495	COG1758	RNA polymerase activity
Acav_3496	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Acav_3513	COG2197	response regulator
Acav_3515	COG1420	regulation of RNA biosynthetic process
Acav_3516	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Acav_3517	COG0497	DNA recombination
Acav_3518	COG1660	Displays ATPase and GTPase activities
Acav_3521	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Acav_3524	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Acav_3525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Acav_3526	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Acav_3527	COG0193	aminoacyl-tRNA hydrolase activity
Acav_3528	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Acav_3530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Acav_3531	COG0444	Belongs to the ABC transporter superfamily
Acav_3532	COG4608	Belongs to the ABC transporter superfamily
Acav_3535	COG0747	negative chemotaxis
Acav_3537	COG3550	peptidyl-serine autophosphorylation
Acav_3542	COG1609	Transcriptional regulator
Acav_3548	COG0302	gtp cyclohydrolase
Acav_3549	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Acav_3550	COG3568	Endonuclease Exonuclease Phosphatase
Acav_3552	COG0494	nUDIX hydrolase
Acav_3555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Acav_3559	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Acav_3562	COG2226	methyltransferase
Acav_3564	COG0745	RESPONSE REGULATOR receiver
Acav_3564	COG3706	GGDEF domain
Acav_3567	COG0840	transmembrane signaling receptor activity
Acav_3568	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Acav_3569	COG1653	transport
Acav_3571	COG0395	ABC-type sugar transport system, permease component
Acav_3572	COG3842	ATPase activity
Acav_3574	COG0584	glycerophosphoryl diester phosphodiesterase
Acav_3575	COG0840	transmembrane signaling receptor activity
Acav_3576	COG3264	Mechanosensitive ion channel
Acav_3576	COG1511	domain protein
Acav_3578	COG0583	DNA-binding transcription factor activity
Acav_3581	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Acav_3582	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Acav_3584	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Acav_3585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Acav_3586	COG1253	flavin adenine dinucleotide binding
Acav_3588	COG0442	prolyl-tRNA aminoacylation
Acav_3589	COG0494	nUDIX hydrolase
Acav_3590	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Acav_3591	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Acav_3592	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Acav_3593	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Acav_3594	COG0142	geranyltranstransferase activity
Acav_3598	COG0237	dephospho-CoA kinase activity
Acav_3599	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Acav_3600	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Acav_3601	COG0494	nUDIX hydrolase
Acav_3603	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Acav_3604	COG0653	protein targeting
Acav_3605	COG0739	heme binding
Acav_3607	COG2969	positive regulation of protein catabolic process
Acav_3608	COG0625	glutathione transferase activity
Acav_3609	COG2857	Cytochrome c1
Acav_3610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Acav_3611	COG0723	plastoquinol--plastocyanin reductase activity
Acav_3612	COG1970	mechanosensitive ion channel activity
Acav_3613	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Acav_3614	COG1136	(ABC) transporter
Acav_3615	COG4591	ABC-type transport system involved in lipoprotein release permease component
Acav_3617	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Acav_3618	COG0840	transmembrane signaling receptor activity
Acav_3619	COG0613	PHP domain protein
Acav_3620	COG0009	L-threonylcarbamoyladenylate synthase
Acav_3621	COG0840	transmembrane signaling receptor activity
Acav_3622	COG1994	Peptidase M50
Acav_3623	COG0180	Tryptophanyl-tRNA synthetase
Acav_3624	COG0431	NADPH-dependent FMN reductase
Acav_3625	COG1393	Belongs to the ArsC family
Acav_3626	COG0640	Transcriptional regulator
Acav_3627	COG3209	COG3209 Rhs family protein
Acav_3634	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Acav_3645	COG4774	siderophore transport
Acav_3655	COG1595	DNA-templated transcription, initiation
Acav_3657	COG4689	acetoacetate decarboxylase
Acav_3658	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_3661	COG0523	cobalamin synthesis protein
Acav_3665	COG0179	Fumarylacetoacetate (FAA) hydrolase
Acav_3666	COG0583	DNA-binding transcription factor activity
Acav_3671	COG0443	Heat shock 70 kDa protein
Acav_3674	COG0038	chloride channel
Acav_3675	COG3209	COG3209 Rhs family protein
Acav_3676	COG3501	Rhs element vgr protein
Acav_3677	COG0612	Peptidase, M16
Acav_3679	COG0765	amino acid transport
Acav_3680	COG0765	amino acid transport
Acav_3681	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acav_3682	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acav_3684	COG1137	ATPase activity
Acav_3702	COG2963	transposase activity
Acav_3707	COG1309	transcriptional regulator
Acav_3708	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Acav_3709	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Acav_3711	COG1253	flavin adenine dinucleotide binding
Acav_3712	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Acav_3713	COG1047	Peptidyl-prolyl cis-trans
Acav_3714	COG2003	Belongs to the UPF0758 family
Acav_3718	COG1193	negative regulation of DNA recombination
Acav_3720	COG0745	RESPONSE REGULATOR receiver
Acav_3723	COG0737	Belongs to the 5'-nucleotidase family
Acav_3724	COG3501	Rhs element vgr protein
Acav_3729	COG3209	COG3209 Rhs family protein
Acav_3732	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Acav_3734	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Acav_3735	COG0243	molybdopterin cofactor binding
Acav_3736	COG0840	transmembrane signaling receptor activity
Acav_3738	COG0489	protein tyrosine kinase activity
Acav_3741	COG0028	Belongs to the TPP enzyme family
Acav_3742	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acav_3742	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acav_3748	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Acav_3750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Acav_3751	COG0156	8-amino-7-oxononanoate synthase activity
Acav_3752	COG0602	queuosine metabolic process
Acav_3753	COG0720	synthase
Acav_3758	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Acav_3760	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Acav_3761	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Acav_3762	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Acav_3763	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Acav_3765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Acav_3766	COG0588	phosphoglycerate mutase activity
Acav_3767	COG0793	Belongs to the peptidase S41A family
Acav_3768	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Acav_3770	COG2197	response regulator
Acav_3772	COG5487	UPF0391 membrane protein
Acav_3777	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Acav_3778	COG0742	ribosomal rna small subunit methyltransferase
Acav_3779	COG0612	Peptidase, M16
Acav_3780	COG0612	Peptidase, M16
Acav_3782	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_3785	COG0840	transmembrane signaling receptor activity
Acav_3786	COG0534	Mate efflux family protein
Acav_3787	COG2095	MarC family integral membrane protein
Acav_3788	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Acav_3792	COG1999	signal sequence binding
Acav_3793	COG0109	protoheme IX farnesyltransferase activity
Acav_3794	COG1612	heme a metabolic process
Acav_3799	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Acav_3803	COG2226	methyltransferase
Acav_3804	COG1040	competence protein
Acav_3805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Acav_3806	COG0583	DNA-binding transcription factor activity
Acav_3809	COG1192	Involved in chromosome partitioning
Acav_3810	COG1280	lysine exporter protein (LysE YggA)
Acav_3812	COG3831	ATPase activity
Acav_3813	COG0714	Associated with various cellular activities
Acav_3814	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Acav_3815	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Acav_3816	COG4715	Zinc finger, swim domain protein
Acav_3817	COG0454	-acetyltransferase
Acav_3817	COG0456	acetyltransferase
Acav_3820	COG1846	Transcriptional regulator
Acav_3821	COG0477	Major facilitator Superfamily
Acav_3822	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Acav_3822	COG2010	Cytochrome c
Acav_3823	COG2080	2 iron, 2 sulfur cluster binding
Acav_3825	COG3473	Maleate cis-trans isomerase
Acav_3826	COG0596	Alpha beta hydrolase
Acav_3827	COG2309	aminopeptidase activity
Acav_3828	COG1335	isochorismatase
Acav_3829	COG2010	Cytochrome c
Acav_3829	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Acav_3833	COG3387	PFAM Glycoside hydrolase 15-related
Acav_3836	COG2031	fatty acid transporter
Acav_3840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Acav_3841	COG0183	Belongs to the thiolase family
Acav_3842	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Acav_3844	COG1414	Transcriptional regulator
Acav_3850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acav_3861	COG0540	Belongs to the ATCase OTCase family
Acav_3863	COG0642	Histidine kinase
Acav_3864	COG0745	RESPONSE REGULATOR receiver
Acav_3865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Acav_3874	COG1518	maintenance of DNA repeat elements
Acav_3875	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Acav_3879	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Acav_3885	COG1132	(ABC) transporter
Acav_3888	COG3045	CreA protein
Acav_3891	COG3145	DNA-N1-methyladenine dioxygenase activity
Acav_3894	COG0753	catalase activity
Acav_3895	COG0745	RESPONSE REGULATOR receiver
Acav_3896	COG2205	protein histidine kinase activity
Acav_3898	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Acav_3901	COG3706	GGDEF domain
Acav_3905	COG0601	transmembrane transport
Acav_3906	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Acav_3908	COG0514	ATP-dependent DNA helicase (RecQ)
Acav_3911	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Acav_3912	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Acav_3913	COG2080	2 iron, 2 sulfur cluster binding
Acav_3920	COG0737	Belongs to the 5'-nucleotidase family
Acav_3921	COG0583	DNA-binding transcription factor activity
Acav_3922	COG2855	membrane
Acav_3923	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Acav_3925	COG1764	response to oxidative stress
Acav_3926	COG1917	Cupin 2, conserved barrel domain protein
Acav_3926	COG4977	sequence-specific DNA binding
Acav_3928	COG0583	DNA-binding transcription factor activity
Acav_3929	COG0601	transmembrane transport
Acav_3930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Acav_3931	COG0444	Belongs to the ABC transporter superfamily
Acav_3932	COG4608	Belongs to the ABC transporter superfamily
Acav_3937	COG0840	transmembrane signaling receptor activity
Acav_3938	COG2267	carboxylic ester hydrolase activity
Acav_3940	COG3002	Belongs to the UPF0753 family
Acav_3941	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Acav_3942	COG0583	DNA-binding transcription factor activity
Acav_3944	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Acav_3945	COG1522	sequence-specific DNA binding
Acav_3947	COG2205	protein histidine kinase activity
Acav_3948	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Acav_3953	COG0583	DNA-binding transcription factor activity
Acav_3957	COG1129	ABC transporter
Acav_3963	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Acav_3964	COG0477	Major facilitator Superfamily
Acav_3965	COG0316	Belongs to the HesB IscA family
Acav_3968	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Acav_3969	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Acav_3971	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Acav_3972	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Acav_3976	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Acav_3978	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Acav_3980	COG2076	Multidrug Resistance protein
Acav_3985	COG1126	abc transporter atp-binding protein
Acav_3986	COG0765	amino acid transport
Acav_3987	COG0765	amino acid transport
Acav_3988	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acav_3990	COG0583	DNA-binding transcription factor activity
Acav_3991	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Acav_3993	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Acav_3994	COG5265	(ABC) transporter
Acav_3995	COG1607	acyl-coa hydrolase
Acav_3997	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_3998	COG1024	Enoyl-CoA hydratase
Acav_4000	COG0183	Belongs to the thiolase family
Acav_4002	COG1024	Enoyl-CoA hydratase
Acav_4002	COG1250	3-hydroxyacyl-CoA dehydrogenase
Acav_4004	COG1960	acyl-CoA dehydrogenase activity
Acav_4006	COG1309	transcriptional regulator
Acav_4008	COG0745	RESPONSE REGULATOR receiver
Acav_4009	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Acav_4017	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Acav_4020	COG1450	Type ii and iii secretion system protein
Acav_4026	COG2165	general secretion pathway protein
Acav_4028	COG2165	general secretion pathway protein
Acav_4029	COG1459	type II secretion system
Acav_4030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Acav_4038	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Acav_4039	COG1652	LysM domain
Acav_4044	COG0204	Acyl-transferase
Acav_4045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Acav_4047	COG0751	glycine-tRNA ligase activity
Acav_4048	COG0752	glycyl-tRNA synthetase alpha subunit
Acav_4049	COG3258	Cytochrome c
Acav_4051	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Acav_4054	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Acav_4055	COG4535	Mg2 and Co2 transporter CorC
Acav_4056	COG3209	COG3209 Rhs family protein
Acav_4058	COG1522	sequence-specific DNA binding
Acav_4059	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
Acav_4063	COG3186	Phenylalanine-4-hydroxylase
Acav_4066	COG0318	PFAM AMP-dependent synthetase and ligase
Acav_4067	COG1879	ABC-type sugar transport system periplasmic component
Acav_4068	COG1129	ABC transporter
Acav_4069	COG1172	Belongs to the binding-protein-dependent transport system permease family
Acav_4071	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Acav_4072	COG1869	D-ribose catabolic process
Acav_4075	COG0739	heme binding
Acav_4075	COG0741	lytic transglycosylase activity
Acav_4075	COG1196	nuclear chromosome segregation
Acav_4076	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Acav_4078	COG0625	glutathione transferase activity
Acav_4080	COG0617	tRNA 3'-terminal CCA addition
Acav_4083	COG3387	PFAM Glycoside hydrolase 15-related
Acav_4084	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Acav_4091	COG0456	acetyltransferase
Acav_4094	COG0076	glutamate decarboxylase activity
Acav_4095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acav_4097	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Acav_4098	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Acav_4100	COG2175	clavaminate synthase activity
Acav_4105	COG3842	ATPase activity
Acav_4107	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_4109	COG2879	small protein
Acav_4110	COG1966	Carbon starvation protein
Acav_4113	COG0037	tRNA processing
Acav_4115	COG0406	alpha-ribazole phosphatase activity
Acav_4120	COG2255	four-way junction helicase activity
Acav_4123	COG0632	four-way junction helicase activity
Acav_4124	COG1702	phosphate starvation-inducible protein PhoH
Acav_4129	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Acav_4130	COG1490	D-aminoacyl-tRNA deacylase activity
Acav_4131	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Acav_4134	COG2188	Transcriptional regulator
Acav_4135	COG0513	Belongs to the DEAD box helicase family
Acav_4136	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Acav_4137	COG3706	GGDEF domain
Acav_4139	COG2814	Major facilitator Superfamily
Acav_4141	COG3485	protocatechuate 3,4-dioxygenase
Acav_4150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Acav_4151	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Acav_4151	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Acav_4153	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Acav_4153	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Acav_4157	COG0443	Heat shock 70 kDa protein
Acav_4159	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Acav_4162	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Acav_4163	COG0583	DNA-binding transcription factor activity
Acav_4164	COG1250	3-hydroxyacyl-CoA dehydrogenase
Acav_4166	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Acav_4168	COG0251	oxidation-reduction process
Acav_4170	COG0179	Fumarylacetoacetate (FAA) hydrolase
Acav_4171	COG3971	2-oxopent-4-enoate hydratase activity
Acav_4173	COG1846	Transcriptional regulator
Acav_4174	COG1764	response to oxidative stress
Acav_4176	COG2815	serine threonine protein kinase
Acav_4176	COG0515	serine threonine protein kinase
Acav_4177	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Acav_4178	COG0745	RESPONSE REGULATOR receiver
Acav_4190	COG0326	Molecular chaperone. Has ATPase activity
Acav_4192	COG1187	pseudouridine synthase activity
Acav_4195	COG0840	transmembrane signaling receptor activity
Acav_4197	COG3250	beta-galactosidase activity
Acav_4199	COG3568	Endonuclease Exonuclease Phosphatase
Acav_4200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Acav_4201	COG0392	lysyltransferase activity
Acav_4202	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Acav_4209	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_4211	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Acav_4212	COG1024	Enoyl-CoA hydratase
Acav_4213	COG1960	acyl-CoA dehydrogenase activity
Acav_4214	COG1960	acyl-CoA dehydrogenase activity
Acav_4215	COG1024	Enoyl-CoA hydratase
Acav_4215	COG1250	3-hydroxyacyl-CoA dehydrogenase
Acav_4216	COG0583	DNA-binding transcription factor activity
Acav_4217	COG1280	lysine exporter protein (LysE YggA)
Acav_4218	COG1522	sequence-specific DNA binding
Acav_4219	COG0501	Belongs to the peptidase M48B family
Acav_4222	COG0418	dihydroorotase activity
Acav_4223	COG2205	protein histidine kinase activity
Acav_4224	COG0745	RESPONSE REGULATOR receiver
Acav_4227	COG0577	efflux transmembrane transporter activity
Acav_4227	COG1136	(ABC) transporter
Acav_4233	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Acav_4241	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Acav_4244	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Acav_4250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Acav_4253	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Acav_4254	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Acav_4255	COG0318	PFAM AMP-dependent synthetase and ligase
Acav_4258	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Acav_4260	COG3012	SEC-C Motif Domain Protein
Acav_4262	COG1960	acyl-CoA dehydrogenase activity
Acav_4265	COG0183	Belongs to the thiolase family
Acav_4266	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Acav_4267	COG0288	reversible hydration of carbon dioxide
Acav_4268	COG1960	acyl-CoA dehydrogenase activity
Acav_4269	COG0789	Transcriptional regulator
Acav_4271	COG2201	protein-glutamate methylesterase activity
Acav_4272	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Acav_4273	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Acav_4274	COG0835	chemotaxis
Acav_4275	COG0643	Histidine kinase
Acav_4275	COG2198	Histidine kinase
Acav_4276	COG0745	RESPONSE REGULATOR receiver
Acav_4281	COG1987	bacterial-type flagellum assembly
Acav_4284	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Acav_4286	COG1580	Controls the rotational direction of flagella during chemotaxis
Acav_4292	COG1766	The M ring may be actively involved in energy transduction
Acav_4301	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Acav_4302	COG1216	Glycosyl transferase, family 2
Acav_4302	COG0438	transferase activity, transferring glycosyl groups
Acav_4303	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Acav_4304	COG1360	Flagellar Motor Protein
Acav_4305	COG0745	RESPONSE REGULATOR receiver
Acav_4306	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Acav_4315	COG1815	bacterial-type flagellum-dependent cell motility
Acav_4316	COG1558	bacterial-type flagellum-dependent cell motility
Acav_4317	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Acav_4318	COG1749	Flagellar hook protein flgE
Acav_4319	COG4787	bacterial-type flagellum-dependent cell motility
Acav_4320	COG4786	Flagellar basal body rod
Acav_4321	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Acav_4322	COG1706	bacterial-type flagellum-dependent cell motility
Acav_4323	COG1705	Flagellar rod assembly protein muramidase FlgJ
Acav_4323	COG3951	Flagellar rod assembly protein muramidase FlgJ
Acav_4324	COG1256	bacterial-type flagellum assembly
Acav_4325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Acav_4327	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acav_4329	COG0697	spore germination
Acav_4330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acav_4331	COG0625	glutathione transferase activity
Acav_4332	COG0384	phenazine biosynthesis protein PhzF
Acav_4338	COG0840	transmembrane signaling receptor activity
Acav_4355	COG0861	Integral membrane protein TerC family
Acav_4356	COG0583	DNA-binding transcription factor activity
Acav_4363	COG3119	arylsulfatase activity
Acav_4366	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Acav_4367	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Acav_4371	COG0210	DNA helicase
Acav_4374	COG0589	response to stress
Acav_4375	COG0343	queuine tRNA-ribosyltransferase activity
Acav_4377	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_4386	COG1522	sequence-specific DNA binding
Acav_4387	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Acav_4388	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_4389	COG0840	transmembrane signaling receptor activity
Acav_4407	COG3181	Tripartite tricarboxylate transporter family receptor
Acav_4408	COG2072	flavoprotein involved in K transport
Acav_4410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acav_4414	COG2365	Tyrosine phosphatase family
Acav_4416	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_4418	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Acav_4419	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Acav_4419	COG1116	anion transmembrane transporter activity
Acav_4422	COG3046	protein related to deoxyribodipyrimidine photolyase
Acav_4424	COG3550	peptidyl-serine autophosphorylation
Acav_4425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Acav_4426	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Acav_4431	COG0270	DNA (cytosine-5-)-methyltransferase activity
Acav_4435	COG2032	superoxide dismutase activity
Acav_4436	COG0243	molybdopterin cofactor binding
Acav_4439	COG3550	peptidyl-serine autophosphorylation
Acav_4441	COG2204	response regulator
Acav_4442	COG5000	phosphorelay sensor kinase activity
Acav_4444	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Acav_4444	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Acav_4446	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Acav_4447	COG0085	RNA polymerase activity
Acav_4448	COG0222	ribosome binding
Acav_4449	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Acav_4451	COG0081	regulation of translation
Acav_4452	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Acav_4454	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Acav_4455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Acav_4456	COG0189	ligase activity
Acav_4457	COG3135	benzoate transporter
Acav_4458	COG3158	transport of potassium into the cell
Acav_4460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Acav_4461	COG0569	domain protein
Acav_4462	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Acav_4464	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acav_4468	COG0495	leucyl-tRNA aminoacylation
Acav_4470	COG3300	MHYT domain
Acav_4470	COG5001	Diguanylate cyclase
Acav_4474	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Acav_4475	COG0735	belongs to the Fur family
Acav_4476	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Acav_4478	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Acav_4479	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Acav_4481	COG3118	belongs to the thioredoxin family
Acav_4482	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Acav_4483	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Acav_4484	COG0009	L-threonylcarbamoyladenylate synthase
Acav_4489	COG1214	PFAM Peptidase M22, glycoprotease
Acav_4492	COG0598	Magnesium transport protein CorA
Acav_4494	COG0318	PFAM AMP-dependent synthetase and ligase
Acav_4498	COG0745	RESPONSE REGULATOR receiver
Acav_4501	COG0469	pyruvate kinase activity
Acav_4502	COG2205	protein histidine kinase activity
Acav_4503	COG0745	RESPONSE REGULATOR receiver
Acav_4505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Acav_4507	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
Acav_4508	COG0006	proline dipeptidase activity
Acav_4512	COG2268	Band 7 protein
Acav_4513	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Acav_4514	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Acav_4515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Acav_4518	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Acav_4520	COG0583	DNA-binding transcription factor activity
Acav_4527	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Acav_4538	COG0668	transmembrane transport
Acav_4540	COG2194	sulfuric ester hydrolase activity
Acav_4541	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_4551	COG1714	RDD family
Acav_4558	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Acav_4558	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Acav_4566	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Acav_4569	COG0642	Histidine kinase
Acav_4572	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Acav_4573	COG2137	regulation of response to DNA damage stimulus
Acav_4575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Acav_4576	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Acav_4577	COG1862	Preprotein translocase
Acav_4582	COG1522	sequence-specific DNA binding
Acav_4584	COG2814	Major facilitator Superfamily
Acav_4587	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Acav_4591	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acav_4593	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Acav_4594	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Acav_4597	COG1309	transcriptional regulator
Acav_4599	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Acav_4604	COG0625	glutathione transferase activity
Acav_4606	COG4681	YaeQ
Acav_4609	COG0861	Integral membrane protein TerC family
Acav_4611	COG1950	PFAM Membrane protein of
Acav_4612	COG4783	chaperone-mediated protein folding
Acav_4613	COG0315	cyclic pyranopterin monophosphate synthase activity
Acav_4617	COG3307	-O-antigen
Acav_4619	COG1716	ATPase activity
Acav_4621	COG0861	Integral membrane protein TerC family
Acav_4622	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Acav_4623	COG0045	succinate-CoA ligase (ADP-forming) activity
Acav_4624	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Acav_4625	COG0758	DNA mediated transformation
Acav_4627	COG0242	peptide deformylase activity
Acav_4629	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Acav_4632	COG0126	phosphoglycerate kinase activity
Acav_4633	COG0284	orotidine-5'-phosphate decarboxylase activity
Acav_4641	COG0840	transmembrane signaling receptor activity
Acav_4647	COG4948	Mandelate Racemase Muconate Lactonizing
Acav_4649	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Acav_4650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Acav_4651	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Acav_4653	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Acav_4656	COG1609	Transcriptional regulator
Acav_4658	COG3842	ATPase activity
Acav_4660	COG1175	transmembrane transport
Acav_4661	COG0395	ABC-type sugar transport system, permease component
Acav_4662	COG3386	PFAM SMP-30 Gluconolaconase
Acav_4666	COG0529	Catalyzes the synthesis of activated sulfate
Acav_4668	COG2814	Major facilitator Superfamily
Acav_4670	COG0629	single-stranded DNA binding
Acav_4671	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Acav_4676	COG0732	type I restriction modification DNA specificity domain
Acav_4677	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Acav_4682	COG2200	EAL domain
Acav_4690	COG0640	Transcriptional regulator
Acav_4694	COG1028	Short-chain dehydrogenase reductase Sdr
Acav_4699	COG1620	l-lactate permease
Acav_4704	COG0482	sulfurtransferase activity
Acav_4707	COG0583	DNA-binding transcription factor activity
Acav_4710	COG3706	GGDEF domain
Acav_4711	COG0307	riboflavin synthase, alpha
Acav_4715	COG2375	cellular response to nickel ion
Acav_4716	COG1695	Transcriptional regulator
Acav_4718	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Acav_4737	COG3706	GGDEF domain
Acav_4737	COG0745	RESPONSE REGULATOR receiver
Acav_4738	COG1802	Transcriptional regulator
Acav_4740	COG0559	Belongs to the binding-protein-dependent transport system permease family
Acav_4743	COG0410	ABC transporter
Acav_4748	COG0280	phosphate acetyltransferase
Acav_4748	COG0281	malic enzyme
Acav_4751	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Acav_4752	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Acav_4753	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Acav_4755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Acav_4758	COG1196	nuclear chromosome segregation
Acav_4760	COG3706	GGDEF domain
Acav_4761	COG2814	Major facilitator Superfamily
Acav_4765	COG0531	amino acid
Acav_4766	COG4303	Ethanolamine ammonia lyase large subunit
Acav_4767	COG4302	ethanolamine ammonia-lyase activity
Acav_4768	COG3706	GGDEF domain
Acav_4768	COG0745	RESPONSE REGULATOR receiver
Acav_4770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Acav_4771	COG2119	membrane
Acav_4772	COG0724	RNA recognition motif
Acav_4773	COG0724	RNA recognition motif
Acav_4774	COG0300	oxidoreductase activity
Acav_4776	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Acav_4779	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Acav_4783	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Acav_4786	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Acav_4787	COG0594	ribonuclease P activity
Acav_4788	COG0230	Belongs to the bacterial ribosomal protein bL34 family