locus-tag	class	description
LKW27_00010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LKW27_00015	COG0791	NLP P60 protein
LKW27_00020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LKW27_00035	COG2176	DNA-directed DNA polymerase activity
LKW27_00050	COG1199	ATP-dependent helicase activity
LKW27_00070	COG1764	response to oxidative stress
LKW27_00120	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LKW27_00125	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LKW27_00130	COG0594	ribonuclease P activity
LKW27_00135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LKW27_00140	COG0706	membrane insertase activity
LKW27_00150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LKW27_00170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LKW27_00185	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LKW27_00195	COG0300	oxidoreductase activity
LKW27_00200	COG0724	RNA recognition motif
LKW27_00205	COG0724	RNA recognition motif
LKW27_00210	COG2119	membrane
LKW27_00215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LKW27_00220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LKW27_00230	COG4302	ethanolamine ammonia-lyase activity
LKW27_00235	COG4303	Ethanolamine ammonia lyase large subunit
LKW27_00240	COG1113	amino acid transport
LKW27_00245	COG2207	Transcriptional regulator
LKW27_00255	COG2814	Major facilitator Superfamily
LKW27_00260	COG1196	nuclear chromosome segregation
LKW27_00275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LKW27_00285	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LKW27_00290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LKW27_00295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LKW27_00310	COG0280	phosphate acetyltransferase
LKW27_00310	COG0281	malic enzyme
LKW27_00360	COG1802	Transcriptional regulator
LKW27_00420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LKW27_00425	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LKW27_00450	COG0307	riboflavin synthase, alpha
LKW27_00480	COG0494	nUDIX hydrolase
LKW27_00485	COG0482	sulfurtransferase activity
LKW27_00490	COG1620	l-lactate permease
LKW27_00515	COG0640	Transcriptional regulator
LKW27_00540	COG0629	single-stranded DNA binding
LKW27_00550	COG2814	Major facilitator Superfamily
LKW27_00560	COG0529	Catalyzes the synthesis of activated sulfate
LKW27_00590	COG0840	transmembrane signaling receptor activity
LKW27_00620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LKW27_00625	COG0284	orotidine-5'-phosphate decarboxylase activity
LKW27_00630	COG0697	spore germination
LKW27_00640	COG0126	phosphoglycerate kinase activity
LKW27_00655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LKW27_00665	COG0242	peptide deformylase activity
LKW27_00675	COG0758	DNA mediated transformation
LKW27_00680	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LKW27_00685	COG0045	succinate-CoA ligase (ADP-forming) activity
LKW27_00690	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LKW27_00695	COG0861	Integral membrane protein TerC family
LKW27_00700	COG0631	protein serine/threonine phosphatase activity
LKW27_00705	COG1716	ATPase activity
LKW27_00715	COG3307	-O-antigen
LKW27_00725	COG0315	cyclic pyranopterin monophosphate synthase activity
LKW27_00730	COG4783	chaperone-mediated protein folding
LKW27_00735	COG1950	PFAM Membrane protein of
LKW27_00745	COG0861	Integral membrane protein TerC family
LKW27_00770	COG0625	glutathione transferase activity
LKW27_00795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LKW27_00805	COG1309	transcriptional regulator
LKW27_00820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LKW27_00825	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LKW27_00855	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LKW27_00875	COG2814	Major facilitator Superfamily
LKW27_00885	COG1522	sequence-specific DNA binding
LKW27_00895	COG1862	Preprotein translocase
LKW27_00900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LKW27_00905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LKW27_00915	COG2137	regulation of response to DNA damage stimulus
LKW27_00920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LKW27_00935	COG0642	Histidine kinase
LKW27_00945	COG0583	DNA-binding transcription factor activity
LKW27_00975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LKW27_00975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LKW27_01010	COG1714	RDD family
LKW27_01065	COG2764	glyoxalase bleomycin resistance protein dioxygenase
LKW27_01080	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_01085	COG2194	sulfuric ester hydrolase activity
LKW27_01095	COG0668	transmembrane transport
LKW27_01150	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LKW27_01185	COG0583	DNA-binding transcription factor activity
LKW27_01195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LKW27_01215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LKW27_01220	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LKW27_01225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LKW27_01230	COG0006	proline dipeptidase activity
LKW27_01235	COG0469	pyruvate kinase activity
LKW27_01270	COG0318	PFAM AMP-dependent synthetase and ligase
LKW27_01280	COG0598	Magnesium transport protein CorA
LKW27_01295	COG1214	PFAM Peptidase M22, glycoprotease
LKW27_01320	COG0009	L-threonylcarbamoyladenylate synthase
LKW27_01325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LKW27_01330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LKW27_01335	COG3118	belongs to the thioredoxin family
LKW27_01345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LKW27_01350	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LKW27_01360	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LKW27_01365	COG0735	belongs to the Fur family
LKW27_01370	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LKW27_01375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LKW27_01390	COG3300	MHYT domain
LKW27_01390	COG5001	Diguanylate cyclase
LKW27_01400	COG0495	leucyl-tRNA aminoacylation
LKW27_01420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LKW27_01425	COG0569	domain protein
LKW27_01440	COG3158	transport of potassium into the cell
LKW27_01445	COG3135	benzoate transporter
LKW27_01450	COG0189	ligase activity
LKW27_01495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LKW27_01505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LKW27_01515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LKW27_01520	COG0081	regulation of translation
LKW27_01525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LKW27_01530	COG0222	ribosome binding
LKW27_01535	COG0085	RNA polymerase activity
LKW27_01540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LKW27_01550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LKW27_01550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LKW27_01560	COG5000	phosphorelay sensor kinase activity
LKW27_01565	COG2204	response regulator
LKW27_01580	COG2032	superoxide dismutase activity
LKW27_01605	COG3046	protein related to deoxyribodipyrimidine photolyase
LKW27_01620	COG1116	anion transmembrane transporter activity
LKW27_01625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LKW27_01635	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_01640	COG2365	Tyrosine phosphatase family
LKW27_01660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_01675	COG2072	flavoprotein involved in K transport
LKW27_01680	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_01720	COG0840	transmembrane signaling receptor activity
LKW27_01730	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LKW27_01735	COG1522	sequence-specific DNA binding
LKW27_01760	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_01795	COG0343	queuine tRNA-ribosyltransferase activity
LKW27_01815	COG0210	DNA helicase
LKW27_01835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LKW27_01845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LKW27_01860	COG3119	arylsulfatase activity
LKW27_01885	COG0583	DNA-binding transcription factor activity
LKW27_01890	COG0861	Integral membrane protein TerC family
LKW27_01925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LKW27_01970	COG0840	transmembrane signaling receptor activity
LKW27_02000	COG0384	phenazine biosynthesis protein PhzF
LKW27_02005	COG0625	glutathione transferase activity
LKW27_02010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LKW27_02015	COG0697	spore germination
LKW27_02025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LKW27_02040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LKW27_02050	COG1705	Flagellar rod assembly protein muramidase FlgJ
LKW27_02050	COG3951	Flagellar rod assembly protein muramidase FlgJ
LKW27_02055	COG1706	bacterial-type flagellum-dependent cell motility
LKW27_02065	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LKW27_02075	COG4787	bacterial-type flagellum-dependent cell motility
LKW27_02085	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LKW27_02090	COG1558	bacterial-type flagellum-dependent cell motility
LKW27_02095	COG1815	bacterial-type flagellum-dependent cell motility
LKW27_02135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LKW27_02140	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LKW27_02145	COG0745	RESPONSE REGULATOR receiver
LKW27_02150	COG1360	Flagellar Motor Protein
LKW27_02155	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LKW27_02160	COG1216	Glycosyl transferase, family 2
LKW27_02160	COG0438	transferase activity, transferring glycosyl groups
LKW27_02165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LKW27_02170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_02180	COG4106	trans-aconitate 2-methyltransferase activity
LKW27_02215	COG1677	Flagellar hook-basal body complex protein FliE
LKW27_02220	COG1766	The M ring may be actively involved in energy transduction
LKW27_02250	COG1580	Controls the rotational direction of flagella during chemotaxis
LKW27_02260	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LKW27_02275	COG1987	bacterial-type flagellum assembly
LKW27_02285	COG2197	response regulator
LKW27_02290	COG3851	Histidine kinase
LKW27_02300	COG0745	RESPONSE REGULATOR receiver
LKW27_02305	COG0643	Histidine kinase
LKW27_02305	COG2198	Histidine kinase
LKW27_02310	COG0835	chemotaxis
LKW27_02315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LKW27_02320	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LKW27_02325	COG2201	protein-glutamate methylesterase activity
LKW27_02330	COG0488	(ABC) transporter
LKW27_02360	COG0789	Transcriptional regulator
LKW27_02370	COG1960	acyl-CoA dehydrogenase activity
LKW27_02375	COG0288	reversible hydration of carbon dioxide
LKW27_02380	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LKW27_02385	COG0183	Belongs to the thiolase family
LKW27_02400	COG1960	acyl-CoA dehydrogenase activity
LKW27_02415	COG3012	SEC-C Motif Domain Protein
LKW27_02420	COG0784	Response regulator, receiver
LKW27_02420	COG2198	Histidine kinase
LKW27_02420	COG2205	protein histidine kinase activity
LKW27_02425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LKW27_02445	COG0318	PFAM AMP-dependent synthetase and ligase
LKW27_02450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LKW27_02455	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LKW27_02470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LKW27_02505	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LKW27_02520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LKW27_02570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LKW27_02600	COG0577	efflux transmembrane transporter activity
LKW27_02600	COG1136	(ABC) transporter
LKW27_02615	COG0745	RESPONSE REGULATOR receiver
LKW27_02620	COG2205	protein histidine kinase activity
LKW27_02625	COG0418	dihydroorotase activity
LKW27_02640	COG0501	Belongs to the peptidase M48B family
LKW27_02645	COG0583	DNA-binding transcription factor activity
LKW27_02650	COG1250	3-hydroxyacyl-CoA dehydrogenase
LKW27_02650	COG1024	Enoyl-CoA hydratase
LKW27_02655	COG1960	acyl-CoA dehydrogenase activity
LKW27_02660	COG1960	acyl-CoA dehydrogenase activity
LKW27_02665	COG1024	Enoyl-CoA hydratase
LKW27_02670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_02705	COG0840	transmembrane signaling receptor activity
LKW27_02715	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LKW27_02720	COG0392	lysyltransferase activity
LKW27_02725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LKW27_02730	COG3568	Endonuclease Exonuclease Phosphatase
LKW27_02750	COG0840	transmembrane signaling receptor activity
LKW27_02780	COG0326	Molecular chaperone. Has ATPase activity
LKW27_02820	COG3209	COG3209 Rhs family protein
LKW27_02865	COG2815	serine threonine protein kinase
LKW27_02865	COG0515	serine threonine protein kinase
LKW27_02880	COG1764	response to oxidative stress
LKW27_02885	COG1846	Transcriptional regulator
LKW27_02895	COG3971	2-oxopent-4-enoate hydratase activity
LKW27_02900	COG0179	Fumarylacetoacetate (FAA) hydrolase
LKW27_02920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LKW27_02930	COG1250	3-hydroxyacyl-CoA dehydrogenase
LKW27_02935	COG0842	Transport permease protein
LKW27_02940	COG1131	(ABC) transporter
LKW27_02945	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LKW27_02955	COG0443	Heat shock 70 kDa protein
LKW27_02975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LKW27_02975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LKW27_02985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LKW27_02985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LKW27_03000	COG3706	GGDEF domain
LKW27_03005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LKW27_03010	COG0513	Belongs to the DEAD box helicase family
LKW27_03015	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LKW27_03020	COG1490	D-aminoacyl-tRNA deacylase activity
LKW27_03025	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LKW27_03045	COG1702	phosphate starvation-inducible protein PhoH
LKW27_03050	COG0632	four-way junction helicase activity
LKW27_03065	COG2255	four-way junction helicase activity
LKW27_03095	COG0037	tRNA processing
LKW27_03105	COG2197	response regulator
LKW27_03110	COG1966	Carbon starvation protein
LKW27_03115	COG2879	small protein
LKW27_03125	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_03140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LKW27_03160	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LKW27_03165	COG3387	PFAM Glycoside hydrolase 15-related
LKW27_03180	COG0617	tRNA 3'-terminal CCA addition
LKW27_03205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LKW27_03210	COG0739	heme binding
LKW27_03210	COG0741	lytic transglycosylase activity
LKW27_03210	COG1196	nuclear chromosome segregation
LKW27_03220	COG1869	D-ribose catabolic process
LKW27_03225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LKW27_03235	COG1172	Belongs to the binding-protein-dependent transport system permease family
LKW27_03240	COG1129	ABC transporter
LKW27_03250	COG0318	PFAM AMP-dependent synthetase and ligase
LKW27_03265	COG3186	Phenylalanine-4-hydroxylase
LKW27_03285	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LKW27_03290	COG1522	sequence-specific DNA binding
LKW27_03305	COG4535	Mg2 and Co2 transporter CorC
LKW27_03310	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LKW27_03325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LKW27_03335	COG3258	Cytochrome c
LKW27_03340	COG0752	glycyl-tRNA synthetase alpha subunit
LKW27_03345	COG0751	glycine-tRNA ligase activity
LKW27_03355	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LKW27_03360	COG0204	Acyl-transferase
LKW27_03380	COG1652	LysM domain
LKW27_03385	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LKW27_03425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LKW27_03430	COG1459	type II secretion system
LKW27_03435	COG2165	general secretion pathway protein
LKW27_03440	COG4970	Tfp pilus assembly protein FimT
LKW27_03445	COG2165	general secretion pathway protein
LKW27_03475	COG1450	Type ii and iii secretion system protein
LKW27_03490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LKW27_03530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LKW27_03535	COG0745	RESPONSE REGULATOR receiver
LKW27_03545	COG1309	transcriptional regulator
LKW27_03555	COG1960	acyl-CoA dehydrogenase activity
LKW27_03575	COG0183	Belongs to the thiolase family
LKW27_03585	COG1024	Enoyl-CoA hydratase
LKW27_03590	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_03605	COG5265	(ABC) transporter
LKW27_03610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LKW27_03615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LKW27_03615	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LKW27_03620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LKW27_03625	COG0583	DNA-binding transcription factor activity
LKW27_03635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LKW27_03640	COG0765	amino acid transport
LKW27_03645	COG0765	amino acid transport
LKW27_03650	COG1126	abc transporter atp-binding protein
LKW27_03680	COG2076	Multidrug Resistance protein
LKW27_03690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LKW27_03700	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LKW27_03720	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LKW27_03725	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LKW27_03735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LKW27_03740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LKW27_03755	COG0316	Belongs to the HesB IscA family
LKW27_03760	COG2814	Major facilitator Superfamily
LKW27_03765	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LKW27_03775	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LKW27_03780	COG0583	DNA-binding transcription factor activity
LKW27_03805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LKW27_03850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LKW27_03855	COG3002	Belongs to the UPF0753 family
LKW27_03865	COG2267	carboxylic ester hydrolase activity
LKW27_03890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LKW27_03900	COG2855	membrane
LKW27_03905	COG0583	DNA-binding transcription factor activity
LKW27_03910	COG0737	Belongs to the 5'-nucleotidase family
LKW27_03950	COG2080	2 iron, 2 sulfur cluster binding
LKW27_03955	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LKW27_03960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LKW27_03980	COG3209	COG3209 Rhs family protein
LKW27_03980	COG3209	COG3209 Rhs family protein
LKW27_04000	COG0514	ATP-dependent DNA helicase (RecQ)
LKW27_04010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LKW27_04015	COG0601	transmembrane transport
LKW27_04050	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LKW27_04060	COG0784	Response regulator, receiver
LKW27_04060	COG5002	protein histidine kinase activity
LKW27_04065	COG0745	RESPONSE REGULATOR receiver
LKW27_04070	COG0753	catalase activity
LKW27_04085	COG3145	DNA-N1-methyladenine dioxygenase activity
LKW27_04100	COG3045	CreA protein
LKW27_04105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LKW27_04105	COG1181	Belongs to the D-alanine--D-alanine ligase family
LKW27_04110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LKW27_04110	COG0189	ligase activity
LKW27_04115	COG1132	(ABC) transporter
LKW27_04145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LKW27_04175	COG0346	lactoylglutathione lyase activity
LKW27_04190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LKW27_04260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LKW27_04290	COG1414	Transcriptional regulator
LKW27_04300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LKW27_04305	COG0183	Belongs to the thiolase family
LKW27_04310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LKW27_04330	COG2031	fatty acid transporter
LKW27_04340	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_04365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LKW27_04365	COG2010	Cytochrome c
LKW27_04370	COG1335	isochorismatase
LKW27_04375	COG2309	aminopeptidase activity
LKW27_04380	COG0596	Alpha beta hydrolase
LKW27_04385	COG3473	Maleate cis-trans isomerase
LKW27_04395	COG2080	2 iron, 2 sulfur cluster binding
LKW27_04400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LKW27_04400	COG2010	Cytochrome c
LKW27_04405	COG0477	Major facilitator Superfamily
LKW27_04410	COG0840	transmembrane signaling receptor activity
LKW27_04415	COG1846	Transcriptional regulator
LKW27_04420	COG3038	cytochrome b561
LKW27_04440	COG4774	siderophore transport
LKW27_04450	COG1280	lysine exporter protein (LysE YggA)
LKW27_04455	COG1192	Involved in chromosome partitioning
LKW27_04470	COG0583	DNA-binding transcription factor activity
LKW27_04475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LKW27_04480	COG1040	competence protein
LKW27_04485	COG2226	methyltransferase
LKW27_04535	COG1612	heme a metabolic process
LKW27_04540	COG0109	protoheme IX farnesyltransferase activity
LKW27_04545	COG1999	signal sequence binding
LKW27_04565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LKW27_04575	COG0583	DNA-binding transcription factor activity
LKW27_04585	COG3842	ATPase activity
LKW27_04620	COG0534	Mate efflux family protein
LKW27_04635	COG4977	sequence-specific DNA binding
LKW27_04640	COG0840	transmembrane signaling receptor activity
LKW27_04665	COG0179	Fumarylacetoacetate (FAA) hydrolase
LKW27_04675	COG0612	Peptidase, M16
LKW27_04680	COG0612	Peptidase, M16
LKW27_04685	COG0742	ribosomal rna small subunit methyltransferase
LKW27_04690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LKW27_04715	COG5487	UPF0391 membrane protein
LKW27_04725	COG2197	response regulator
LKW27_04735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LKW27_04740	COG0793	Belongs to the peptidase S41A family
LKW27_04745	COG0588	phosphoglycerate mutase activity
LKW27_04750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LKW27_04760	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LKW27_04765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LKW27_04770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LKW27_04775	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LKW27_04785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LKW27_04810	COG0720	synthase
LKW27_04815	COG0602	queuosine metabolic process
LKW27_04820	COG0156	8-amino-7-oxononanoate synthase activity
LKW27_04825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LKW27_04835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LKW27_04865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LKW27_04865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LKW27_04870	COG0028	Belongs to the TPP enzyme family
LKW27_04885	COG0489	protein tyrosine kinase activity
LKW27_04890	COG2223	nitrite transmembrane transporter activity
LKW27_04895	COG0840	transmembrane signaling receptor activity
LKW27_04900	COG0243	molybdopterin cofactor binding
LKW27_04905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LKW27_04915	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LKW27_04960	COG0154	amidase activity
LKW27_04970	COG1802	Transcriptional regulator
LKW27_04980	COG3916	Acyl-homoserine-lactone synthase
LKW27_04985	COG2771	luxR family
LKW27_05015	COG0318	PFAM AMP-dependent synthetase and ligase
LKW27_05020	COG0534	Mate efflux family protein
LKW27_05035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LKW27_05110	COG0737	Belongs to the 5'-nucleotidase family
LKW27_05135	COG1193	negative regulation of DNA recombination
LKW27_05155	COG2003	Belongs to the UPF0758 family
LKW27_05160	COG1047	Peptidyl-prolyl cis-trans
LKW27_05165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LKW27_05170	COG1253	flavin adenine dinucleotide binding
LKW27_05175	COG0517	IMP dehydrogenase activity
LKW27_05175	COG0617	tRNA 3'-terminal CCA addition
LKW27_05175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LKW27_05180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LKW27_05185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LKW27_05240	COG0129	dihydroxy-acid dehydratase activity
LKW27_05255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LKW27_05260	COG0765	amino acid transport
LKW27_05265	COG0765	amino acid transport
LKW27_05270	COG0612	Peptidase, M16
LKW27_05280	COG3209	COG3209 Rhs family protein
LKW27_05315	COG0038	chloride channel
LKW27_05360	COG0443	Heat shock 70 kDa protein
LKW27_05415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LKW27_05420	COG4774	siderophore transport
LKW27_05430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LKW27_05505	COG3209	COG3209 Rhs family protein
LKW27_05510	COG0180	Tryptophanyl-tRNA synthetase
LKW27_05515	COG1994	Peptidase M50
LKW27_05525	COG0009	L-threonylcarbamoyladenylate synthase
LKW27_05530	COG0613	PHP domain protein
LKW27_05535	COG0738	Major facilitator superfamily
LKW27_05550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LKW27_05560	COG4591	ABC-type transport system involved in lipoprotein release permease component
LKW27_05565	COG1136	(ABC) transporter
LKW27_05570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LKW27_05575	COG1970	mechanosensitive ion channel activity
LKW27_05580	COG0723	plastoquinol--plastocyanin reductase activity
LKW27_05585	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LKW27_05590	COG2857	Cytochrome c1
LKW27_05595	COG0625	glutathione transferase activity
LKW27_05600	COG2969	positive regulation of protein catabolic process
LKW27_05615	COG0739	heme binding
LKW27_05620	COG0653	protein targeting
LKW27_05625	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LKW27_05635	COG0494	nUDIX hydrolase
LKW27_05640	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LKW27_05645	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LKW27_05650	COG0237	dephospho-CoA kinase activity
LKW27_05670	COG0583	DNA-binding transcription factor activity
LKW27_05680	COG1473	amidohydrolase
LKW27_05690	COG0142	geranyltranstransferase activity
LKW27_05695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LKW27_05700	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LKW27_05705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LKW27_05710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LKW27_05715	COG0494	nUDIX hydrolase
LKW27_05720	COG0442	prolyl-tRNA aminoacylation
LKW27_05730	COG1253	flavin adenine dinucleotide binding
LKW27_05735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LKW27_05740	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LKW27_05750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LKW27_05755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LKW27_05790	COG1511	domain protein
LKW27_05790	COG3264	Mechanosensitive ion channel
LKW27_05795	COG0584	glycerophosphoryl diester phosphodiesterase
LKW27_05805	COG3842	ATPase activity
LKW27_05810	COG0395	ABC-type sugar transport system, permease component
LKW27_05815	COG1175	transmembrane transport
LKW27_05820	COG1653	transport
LKW27_05825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LKW27_05850	COG2226	methyltransferase
LKW27_05865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LKW27_05885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LKW27_05895	COG0494	nUDIX hydrolase
LKW27_05900	COG0745	RESPONSE REGULATOR receiver
LKW27_05910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LKW27_05915	COG0302	gtp cyclohydrolase
LKW27_05945	COG1609	Transcriptional regulator
LKW27_05975	COG0747	negative chemotaxis
LKW27_05985	COG4608	Belongs to the ABC transporter superfamily
LKW27_05990	COG0444	Belongs to the ABC transporter superfamily
LKW27_05995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LKW27_06005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LKW27_06010	COG0193	aminoacyl-tRNA hydrolase activity
LKW27_06015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LKW27_06020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LKW27_06030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LKW27_06045	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LKW27_06055	COG1194	a g-specific adenine glycosylase
LKW27_06060	COG1660	Displays ATPase and GTPase activities
LKW27_06065	COG0497	DNA recombination
LKW27_06070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LKW27_06135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LKW27_06140	COG1420	regulation of RNA biosynthetic process
LKW27_06150	COG2197	response regulator
LKW27_06155	COG3693	PFAM glycoside hydrolase, family 10
LKW27_06185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LKW27_06190	COG1758	RNA polymerase activity
LKW27_06195	COG0194	GDP metabolic process
LKW27_06200	COG1561	YicC-like family, N-terminal region
LKW27_06220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LKW27_06225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LKW27_06240	COG4221	oxidoreductase activity
LKW27_06245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LKW27_06260	COG1595	DNA-templated transcription, initiation
LKW27_06285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LKW27_06290	COG4191	Histidine kinase
LKW27_06290	COG0784	Response regulator, receiver
LKW27_06335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LKW27_06335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LKW27_06360	COG4968	Prepilin-type N-terminal cleavage methylation domain
LKW27_06365	COG4968	Prepilin-type N-terminal cleavage methylation domain
LKW27_06390	COG1063	alcohol dehydrogenase
LKW27_06400	COG2205	protein histidine kinase activity
LKW27_06405	COG2249	NAD(P)H dehydrogenase (quinone) activity
LKW27_06420	COG0464	growth
LKW27_06435	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LKW27_06440	COG0830	nickel cation binding
LKW27_06445	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LKW27_06455	COG0804	urea catabolic process
LKW27_06460	COG0832	Belongs to the urease beta subunit family
LKW27_06470	COG0831	urea catabolic process
LKW27_06485	COG5001	Diguanylate cyclase
LKW27_06505	COG1304	FMN binding
LKW27_06510	COG2205	protein histidine kinase activity
LKW27_06530	COG2814	Major facilitator Superfamily
LKW27_06535	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LKW27_06540	COG4336	lyase activity
LKW27_06545	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LKW27_06550	COG4770	biotin carboxylase activity
LKW27_06560	COG3038	cytochrome b561
LKW27_06580	COG5599	Phosphatase
LKW27_06585	COG1301	dicarboxylic acid transport
LKW27_06630	COG2814	Major facilitator Superfamily
LKW27_06730	COG0697	spore germination
LKW27_06765	COG0583	DNA-binding transcription factor activity
LKW27_06780	COG1283	sodium-dependent phosphate transmembrane transporter activity
LKW27_06790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LKW27_06795	COG3842	ATPase activity
LKW27_06805	COG1177	transmembrane transport
LKW27_06810	COG4149	molybdate abc transporter
LKW27_06820	COG1609	Transcriptional regulator
LKW27_06835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LKW27_06845	COG0196	riboflavin kinase activity
LKW27_06855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LKW27_06865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LKW27_06875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LKW27_06895	COG1960	acyl-CoA dehydrogenase activity
LKW27_06900	COG3132	Protein of unknown function, DUF480
LKW27_06905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LKW27_06920	COG3866	Pectate lyase
LKW27_06925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LKW27_06925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LKW27_06940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LKW27_06945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LKW27_06950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LKW27_06955	COG0492	ferredoxin-NADP+ reductase activity
LKW27_06960	COG1674	ftsk spoiiie
LKW27_06965	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LKW27_06975	COG1573	uracil-dna glycosylase
LKW27_06980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LKW27_06985	COG0840	transmembrane signaling receptor activity
LKW27_06990	COG0559	Belongs to the binding-protein-dependent transport system permease family
LKW27_07010	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LKW27_07010	COG2885	chlorophyll binding
LKW27_07015	COG1392	Phosphate transport regulator
LKW27_07020	COG0306	phosphate transporter
LKW27_07035	COG0228	four-way junction DNA binding
LKW27_07040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LKW27_07045	COG0336	Belongs to the RNA methyltransferase TrmD family
LKW27_07050	COG0335	large ribosomal subunit rRNA binding
LKW27_07060	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LKW27_07065	COG1162	GTPase activity
LKW27_07070	COG2154	pterin-4-alpha-carbinolamine dehydratase
LKW27_07080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LKW27_07085	COG0513	Belongs to the DEAD box helicase family
LKW27_07090	COG3447	MASE1 domain protein
LKW27_07090	COG5001	Diguanylate cyclase
LKW27_07090	COG5002	protein histidine kinase activity
LKW27_07095	COG2814	Major facilitator Superfamily
LKW27_07110	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LKW27_07115	COG5002	protein histidine kinase activity
LKW27_07120	COG2204	response regulator
LKW27_07170	COG0516	GMP reductase activity
LKW27_07255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LKW27_07295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_07300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LKW27_07330	COG0412	Dienelactone hydrolase
LKW27_07340	COG0165	Argininosuccinate lyase
LKW27_07350	COG3275	phosphorelay sensor kinase activity
LKW27_07355	COG0165	Argininosuccinate lyase
LKW27_07390	COG0840	transmembrane signaling receptor activity
LKW27_07395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LKW27_07405	COG1304	FMN binding
LKW27_07410	COG0840	transmembrane signaling receptor activity
LKW27_07430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LKW27_07455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LKW27_07460	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LKW27_07470	COG0617	tRNA 3'-terminal CCA addition
LKW27_07510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_07515	COG1960	acyl-CoA dehydrogenase activity
LKW27_07520	COG0583	DNA-binding transcription factor activity
LKW27_07565	COG2816	NAD+ diphosphatase activity
LKW27_07570	COG0425	Belongs to the sulfur carrier protein TusA family
LKW27_07580	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LKW27_07585	COG0525	valine-tRNA ligase activity
LKW27_07590	COG0501	Belongs to the peptidase M48B family
LKW27_07600	COG0488	(ABC) transporter
LKW27_07620	COG0181	hydroxymethylbilane synthase activity
LKW27_07625	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LKW27_07630	COG1289	transmembrane transporter activity
LKW27_07635	COG0628	permease
LKW27_07690	COG1722	exodeoxyribonuclease VII activity
LKW27_07695	COG0142	geranyltranstransferase activity
LKW27_07700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LKW27_07705	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LKW27_07725	COG0668	transmembrane transport
LKW27_07730	COG0366	Alpha amylase catalytic
LKW27_07735	COG0366	Alpha amylase catalytic
LKW27_07740	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LKW27_07745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LKW27_07750	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LKW27_07770	COG3585	molybdate ion transport
LKW27_07770	COG2005	Transcriptional regulator
LKW27_07780	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LKW27_07790	COG1280	lysine exporter protein (LysE YggA)
LKW27_07795	COG3279	Response regulator of the LytR AlgR family
LKW27_07800	COG3275	phosphorelay sensor kinase activity
LKW27_07830	COG1968	undecaprenyl-diphosphatase activity
LKW27_07835	COG5001	Diguanylate cyclase
LKW27_07835	COG3447	MASE1 domain protein
LKW27_07835	COG5002	protein histidine kinase activity
LKW27_07860	COG3209	COG3209 Rhs family protein
LKW27_07875	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LKW27_07880	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LKW27_07935	COG2205	protein histidine kinase activity
LKW27_07935	COG5002	protein histidine kinase activity
LKW27_07935	COG0784	Response regulator, receiver
LKW27_07940	COG3437	response regulator, receiver
LKW27_07950	COG1132	(ABC) transporter
LKW27_07970	COG0483	inositol monophosphate 1-phosphatase activity
LKW27_07985	COG4555	ABC transporter
LKW27_07990	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LKW27_08000	COG1045	serine acetyltransferase
LKW27_08005	COG0521	Mo-molybdopterin cofactor biosynthetic process
LKW27_08010	COG3028	Belongs to the UPF0307 family
LKW27_08015	COG0312	modulator of DNA gyrase
LKW27_08030	COG2721	sulfolactate sulfo-lyase activity
LKW27_08045	COG0477	Major facilitator Superfamily
LKW27_08050	COG1752	Esterase of the alpha-beta hydrolase superfamily
LKW27_08055	COG0473	3-isopropylmalate dehydrogenase activity
LKW27_08060	COG0583	DNA-binding transcription factor activity
LKW27_08070	COG0625	glutathione transferase activity
LKW27_08075	COG1610	YqeY-like protein
LKW27_08080	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LKW27_08100	COG0640	Transcriptional regulator
LKW27_08105	COG2081	HI0933 family
LKW27_08120	COG0288	reversible hydration of carbon dioxide
LKW27_08125	COG1607	acyl-coa hydrolase
LKW27_08130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LKW27_08130	COG5297	Belongs to the glycosyl hydrolase family 6
LKW27_08140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LKW27_08145	COG0243	molybdopterin cofactor binding
LKW27_08155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LKW27_08160	COG0840	transmembrane signaling receptor activity
LKW27_08175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LKW27_08185	COG0840	transmembrane signaling receptor activity
LKW27_08190	COG0517	IMP dehydrogenase activity
LKW27_08190	COG0516	GMP reductase activity
LKW27_08210	COG0643	Histidine kinase
LKW27_08210	COG2198	Histidine kinase
LKW27_08215	COG0840	transmembrane signaling receptor activity
LKW27_08225	COG0745	RESPONSE REGULATOR receiver
LKW27_08240	COG2223	nitrite transmembrane transporter activity
LKW27_08245	COG3959	Transketolase, thiamine diphosphate binding domain
LKW27_08250	COG3958	Transketolase
LKW27_08255	COG0194	GDP metabolic process
LKW27_08270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LKW27_08285	COG0626	cystathionine gamma-synthase activity
LKW27_08295	COG0724	RNA recognition motif
LKW27_08310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LKW27_08315	COG1116	anion transmembrane transporter activity
LKW27_08320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LKW27_08325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LKW27_08345	COG0683	leucine binding
LKW27_08350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LKW27_08365	COG0683	leucine binding
LKW27_08395	COG2951	lytic endotransglycosylase activity
LKW27_08410	COG0714	Associated with various cellular activities
LKW27_08415	COG0123	including yeast histone deacetylase and acetoin utilization protein
LKW27_08420	COG1024	Enoyl-CoA hydratase
LKW27_08435	COG3264	Mechanosensitive ion channel
LKW27_08435	COG1511	domain protein
LKW27_08450	COG1960	acyl-CoA dehydrogenase activity
LKW27_08495	COG1473	amidohydrolase
LKW27_08500	COG1522	sequence-specific DNA binding
LKW27_08510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LKW27_08530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_08540	COG0601	transmembrane transport
LKW27_08545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LKW27_08555	COG0473	3-isopropylmalate dehydrogenase activity
LKW27_08565	COG2194	sulfuric ester hydrolase activity
LKW27_08570	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LKW27_08580	COG4977	sequence-specific DNA binding
LKW27_08585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LKW27_08600	COG0372	Belongs to the citrate synthase family
LKW27_08605	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LKW27_08610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LKW27_08615	COG1053	succinate dehydrogenase
LKW27_08630	COG2188	Transcriptional regulator
LKW27_08635	COG0039	L-malate dehydrogenase activity
LKW27_08640	COG4106	trans-aconitate 2-methyltransferase activity
LKW27_08655	COG1049	propionate catabolic process, 2-methylcitrate cycle
LKW27_08660	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
LKW27_08675	COG0826	peptidase U32
LKW27_08680	COG0583	DNA-binding transcription factor activity
LKW27_08705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LKW27_08710	COG1845	cytochrome c oxidase, subunit III
LKW27_08715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LKW27_08720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LKW27_08725	COG0477	Major facilitator Superfamily
LKW27_08745	COG0824	Thioesterase
LKW27_08750	COG0436	Aminotransferase
LKW27_08755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LKW27_08760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LKW27_08785	COG2205	protein histidine kinase activity
LKW27_08785	COG2202	Pas domain
LKW27_08795	COG0745	RESPONSE REGULATOR receiver
LKW27_08800	COG2201	protein-glutamate methylesterase activity
LKW27_08820	COG1289	transmembrane transporter activity
LKW27_08825	COG4948	Mandelate Racemase Muconate Lactonizing
LKW27_08830	COG0800	Aldolase
LKW27_08835	COG3734	2-keto-3-deoxy-galactonokinase
LKW27_08850	COG1172	Belongs to the binding-protein-dependent transport system permease family
LKW27_08855	COG1172	Belongs to the binding-protein-dependent transport system permease family
LKW27_08865	COG4214	carbohydrate transport
LKW27_08875	COG4213	ABC transporter substrate-binding protein
LKW27_08880	COG1879	ABC-type sugar transport system periplasmic component
LKW27_08900	COG3386	PFAM SMP-30 Gluconolaconase
LKW27_08910	COG2918	glutathione biosynthetic process
LKW27_08920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LKW27_08935	COG5002	protein histidine kinase activity
LKW27_08950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LKW27_08970	COG2814	Major facilitator Superfamily
LKW27_08985	COG1285	pathogenesis
LKW27_08990	COG0564	pseudouridine synthase activity
LKW27_09020	COG0840	transmembrane signaling receptor activity
LKW27_09050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LKW27_09090	COG1309	transcriptional regulator
LKW27_09105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LKW27_09115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LKW27_09130	COG3384	dioxygenase
LKW27_09150	COG1522	sequence-specific DNA binding
LKW27_09205	COG0215	cysteine-tRNA ligase activity
LKW27_09220	COG0037	tRNA processing
LKW27_09225	COG0527	aspartate kinase activity
LKW27_09290	COG3209	COG3209 Rhs family protein
LKW27_09335	COG0791	NLP P60 protein
LKW27_09340	COG2133	pyrroloquinoline quinone binding
LKW27_09390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LKW27_09390	COG1042	CoA-binding domain protein
LKW27_09390	COG0045	succinate-CoA ligase (ADP-forming) activity
LKW27_09410	COG1309	transcriptional regulator
LKW27_09415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LKW27_09425	COG1136	(ABC) transporter
LKW27_09450	COG4771	TonB-dependent receptor
LKW27_09455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_09470	COG0259	pyridoxamine-phosphate oxidase activity
LKW27_09495	COG1609	Transcriptional regulator
LKW27_09500	COG3265	gluconokinase activity
LKW27_09505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LKW27_09510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LKW27_09515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LKW27_09525	COG0800	Aldolase
LKW27_09535	COG0346	lactoylglutathione lyase activity
LKW27_09540	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_09585	COG0583	DNA-binding transcription factor activity
LKW27_09590	COG0431	NADPH-dependent FMN reductase
LKW27_09600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LKW27_09630	COG0564	pseudouridine synthase activity
LKW27_09635	COG2982	Protein involved in outer membrane biogenesis
LKW27_09640	COG0587	DNA-directed DNA polymerase activity
LKW27_09655	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LKW27_09680	COG1012	belongs to the aldehyde dehydrogenase family
LKW27_09705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LKW27_09710	COG0746	molybdenum cofactor guanylyltransferase activity
LKW27_09720	COG0303	'Molybdopterin
LKW27_09735	COG0328	RNA-DNA hybrid ribonuclease activity
LKW27_09740	COG2226	methyltransferase
LKW27_09745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LKW27_09805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LKW27_09810	COG0741	lytic transglycosylase activity
LKW27_09810	COG1388	LysM domain
LKW27_09830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LKW27_09835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LKW27_09840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LKW27_09855	COG2081	HI0933 family
LKW27_09860	COG1074	ATP-dependent DNA helicase activity
LKW27_09875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LKW27_09880	COG0419	ATPase involved in DNA repair
LKW27_09885	COG0420	3'-5' exonuclease activity
LKW27_09890	COG0254	rRNA binding
LKW27_09900	COG0534	Mate efflux family protein
LKW27_09915	COG0704	Plays a role in the regulation of phosphate uptake
LKW27_09920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LKW27_09925	COG0581	inorganic phosphate transmembrane transporter activity
LKW27_09930	COG0573	inorganic phosphate transmembrane transporter activity
LKW27_09935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LKW27_09940	COG0248	Ppx GppA phosphatase
LKW27_09970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LKW27_09980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LKW27_09985	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LKW27_09990	COG1534	Rna-binding protein
LKW27_10005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LKW27_10010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LKW27_10015	COG0505	Belongs to the CarA family
LKW27_10025	COG1113	amino acid transport
LKW27_10050	COG1960	acyl-CoA dehydrogenase activity
LKW27_10065	COG2032	superoxide dismutase activity
LKW27_10070	COG4772	TonB-dependent receptor
LKW27_10085	COG2721	sulfolactate sulfo-lyase activity
LKW27_10100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LKW27_10110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LKW27_10120	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_10125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LKW27_10165	COG0789	Transcriptional regulator
LKW27_10170	COG2814	Major facilitator Superfamily
LKW27_10185	COG1942	4-Oxalocrotonate Tautomerase
LKW27_10190	COG0625	glutathione transferase activity
LKW27_10220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LKW27_10225	COG1570	exodeoxyribonuclease VII activity
LKW27_10230	COG0811	peptide transport
LKW27_10235	COG0848	biopolymer transport protein
LKW27_10240	COG1663	tetraacyldisaccharide 4'-kinase activity
LKW27_10245	COG2835	tetraacyldisaccharide 4'-kinase activity
LKW27_10250	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LKW27_10255	COG0563	adenylate kinase activity
LKW27_10265	COG0252	asparaginase activity
LKW27_10270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LKW27_10280	COG1643	Atp-dependent helicase
LKW27_10290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_10295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LKW27_10295	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LKW27_10320	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LKW27_10325	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LKW27_10330	COG4208	sulfate ABC transporter
LKW27_10335	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LKW27_10340	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LKW27_10360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LKW27_10380	COG2011	ABC-type metal ion transport system permease component
LKW27_10385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LKW27_10395	COG2814	Major facilitator Superfamily
LKW27_10400	COG0583	DNA-binding transcription factor activity
LKW27_10405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LKW27_10420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LKW27_10435	COG5002	protein histidine kinase activity
LKW27_10475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LKW27_10495	COG4770	biotin carboxylase activity
LKW27_10505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LKW27_10510	COG1703	isobutyryl-CoA mutase activity
LKW27_10520	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LKW27_10520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LKW27_10525	COG1802	Transcriptional regulator
LKW27_10590	COG0840	transmembrane signaling receptor activity
LKW27_10605	COG3039	Transposase
LKW27_10620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LKW27_10640	COG2878	Part of a membrane complex involved in electron transport
LKW27_10645	COG0840	transmembrane signaling receptor activity
LKW27_10655	COG2171	N-acyltransferase activity
LKW27_10665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LKW27_10670	COG2890	protein-(glutamine-N5) methyltransferase activity
LKW27_10675	COG0488	(ABC) transporter
LKW27_10680	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_10685	COG0183	Belongs to the thiolase family
LKW27_10690	COG3243	poly(R)-hydroxyalkanoic acid synthase
LKW27_10720	COG0515	serine threonine protein kinase
LKW27_10730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LKW27_10735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LKW27_10760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LKW27_10765	COG0508	dehydrogenase complex catalyzes the overall conversion of
LKW27_10770	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LKW27_10780	COG4566	intracellular signal transduction
LKW27_10785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LKW27_10800	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LKW27_10805	COG0167	dihydroorotate dehydrogenase activity
LKW27_10825	COG0579	oxidoreductase
LKW27_10850	COG0633	Ferredoxin
LKW27_10855	COG0443	Heat shock 70 kDa protein
LKW27_10860	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LKW27_10870	COG0822	iron-sulfur transferase activity
LKW27_10875	COG1104	cysteine desulfurase activity
LKW27_10880	COG1959	2 iron, 2 sulfur cluster binding
LKW27_10885	COG0556	nucleotide-excision repair
LKW27_10895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_10910	COG0840	transmembrane signaling receptor activity
LKW27_10925	COG1739	Uncharacterized protein family UPF0029
LKW27_10945	COG0154	amidase activity
LKW27_10950	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_10955	COG3048	D-serine ammonia-lyase activity
LKW27_10980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LKW27_11050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LKW27_11060	COG1196	nuclear chromosome segregation
LKW27_11070	COG1742	UPF0060 membrane protein
LKW27_11080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LKW27_11085	COG1132	(ABC) transporter
LKW27_11110	COG0789	Transcriptional regulator
LKW27_11115	COG0776	regulation of translation
LKW27_11120	COG0072	phenylalanine-tRNA ligase activity
LKW27_11120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LKW27_11125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LKW27_11130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LKW27_11135	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LKW27_11140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LKW27_11145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LKW27_11150	COG2224	Isocitrate lyase
LKW27_11165	COG1522	sequence-specific DNA binding
LKW27_11170	COG0697	spore germination
LKW27_11180	COG1840	ABC-type Fe3 transport system, periplasmic component
LKW27_11200	COG2153	protein acetylation
LKW27_11205	COG2130	NADP-dependent
LKW27_11225	COG1960	acyl-CoA dehydrogenase activity
LKW27_11230	COG2050	protein possibly involved in aromatic compounds catabolism
LKW27_11235	COG0183	Belongs to the thiolase family
LKW27_11240	COG1250	3-hydroxyacyl-CoA dehydrogenase
LKW27_11240	COG1024	Enoyl-CoA hydratase
LKW27_11255	COG3706	GGDEF domain
LKW27_11280	COG0411	ABC transporter
LKW27_11290	COG0559	Belongs to the binding-protein-dependent transport system permease family
LKW27_11300	COG0318	PFAM AMP-dependent synthetase and ligase
LKW27_11305	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LKW27_11310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LKW27_11315	COG2917	probably involved in intracellular septation
LKW27_11325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LKW27_11345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LKW27_11350	COG0688	phosphatidylethanolamine metabolic process
LKW27_11365	COG5006	permease, DMT superfamily
LKW27_11380	COG1228	amidohydrolase
LKW27_11395	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LKW27_11400	COG2986	histidine ammonia-lyase
LKW27_11405	COG2188	Transcriptional regulator
LKW27_11415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LKW27_11425	COG1366	Belongs to the anti-sigma-factor antagonist family
LKW27_11430	COG1366	Belongs to the anti-sigma-factor antagonist family
LKW27_11435	COG2172	sigma factor antagonist activity
LKW27_11445	COG2205	protein histidine kinase activity
LKW27_11450	COG2205	protein histidine kinase activity
LKW27_11455	COG0784	Response regulator, receiver
LKW27_11455	COG4191	Histidine kinase
LKW27_11475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LKW27_11495	COG0297	glycogen (starch) synthase activity
LKW27_11500	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_11505	COG0557	exoribonuclease II activity
LKW27_11530	COG0741	lytic transglycosylase activity
LKW27_11535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LKW27_11540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LKW27_11550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LKW27_11555	COG0517	IMP dehydrogenase activity
LKW27_11555	COG1125	glycine betaine transport
LKW27_11570	COG1011	Hydrolase
LKW27_11575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LKW27_11580	COG5002	protein histidine kinase activity
LKW27_11630	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_11640	COG0642	Histidine kinase
LKW27_11655	COG0667	Aldo Keto reductase
LKW27_11660	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LKW27_11665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LKW27_11670	COG4181	ATPase activity
LKW27_11710	COG1054	Belongs to the UPF0176 family
LKW27_11715	COG1741	Belongs to the pirin family
LKW27_11725	COG1741	Belongs to the pirin family
LKW27_11730	COG0583	DNA-binding transcription factor activity
LKW27_11735	COG0493	'glutamate synthase
LKW27_11735	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LKW27_11740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LKW27_11745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LKW27_11755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LKW27_11780	COG0583	DNA-binding transcription factor activity
LKW27_11790	COG1116	anion transmembrane transporter activity
LKW27_11795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LKW27_11805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LKW27_11815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LKW27_11825	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LKW27_11830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_11830	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LKW27_11845	COG0730	response to heat
LKW27_11860	COG0175	sulfate reduction
LKW27_11865	COG0529	Catalyzes the synthesis of activated sulfate
LKW27_11865	COG2895	sulfate adenylyltransferase (ATP) activity
LKW27_11870	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LKW27_11875	COG0492	ferredoxin-NADP+ reductase activity
LKW27_11925	COG0351	phosphomethylpyrimidine kinase
LKW27_11940	COG2022	thiamine diphosphate biosynthetic process
LKW27_11955	COG1250	3-hydroxyacyl-CoA dehydrogenase
LKW27_11960	COG1024	Enoyl-CoA hydratase
LKW27_11975	COG1960	acyl-CoA dehydrogenase activity
LKW27_11990	COG1619	proteins homologs of microcin C7 resistance protein MccF
LKW27_12015	COG0826	peptidase U32
LKW27_12030	COG0823	Involved in the tonB-independent uptake of proteins
LKW27_12030	COG1506	peptidase
LKW27_12030	COG4946	Tricorn protease homolog
LKW27_12040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LKW27_12045	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LKW27_12060	COG3047	cAMP biosynthetic process
LKW27_12065	COG2354	Protein conserved in bacteria
LKW27_12070	COG3300	MHYT domain
LKW27_12070	COG5001	Diguanylate cyclase
LKW27_12085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LKW27_12085	COG0047	phosphoribosylformylglycinamidine synthase activity
LKW27_12090	COG0024	Methionine aminopeptidase
LKW27_12095	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LKW27_12100	COG0242	peptide deformylase activity
LKW27_12105	COG2832	Protein of unknown function (DUF454)
LKW27_12120	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LKW27_12125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LKW27_12130	COG1414	Transcriptional regulator
LKW27_12140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LKW27_12145	COG1183	phosphatidylcholine synthase activity
LKW27_12150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LKW27_12155	COG0440	acetolactate synthase activity
LKW27_12160	COG0028	Belongs to the TPP enzyme family
LKW27_12170	COG1595	DNA-templated transcription, initiation
LKW27_12190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LKW27_12200	COG0347	Belongs to the P(II) protein family
LKW27_12215	COG0583	DNA-binding transcription factor activity
LKW27_12225	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_12230	COG0835	chemotaxis
LKW27_12255	COG1252	NADH dehydrogenase
LKW27_12265	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LKW27_12300	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_12320	COG4120	Belongs to the binding-protein-dependent transport system permease family
LKW27_12335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LKW27_12340	COG0509	glycine decarboxylation via glycine cleavage system
LKW27_12345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LKW27_12345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LKW27_12350	COG0545	Peptidyl-prolyl cis-trans isomerase
LKW27_12360	COG0564	pseudouridine synthase activity
LKW27_12365	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_12385	COG0589	response to stress
LKW27_12425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LKW27_12445	COG0583	DNA-binding transcription factor activity
LKW27_12450	COG0436	Aminotransferase
LKW27_12485	COG0683	leucine binding
LKW27_12495	COG1960	acyl-CoA dehydrogenase activity
LKW27_12500	COG1024	Enoyl-CoA hydratase
LKW27_12510	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_12525	COG0596	Alpha beta hydrolase
LKW27_12530	COG2205	protein histidine kinase activity
LKW27_12540	COG3593	DNA synthesis involved in DNA repair
LKW27_12550	COG0210	DNA helicase
LKW27_12585	COG1530	ribonuclease E activity
LKW27_12590	COG0424	maF-like protein
LKW27_12600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LKW27_12605	COG0799	negative regulation of ribosome biogenesis
LKW27_12610	COG0408	coproporphyrinogen oxidase activity
LKW27_12615	COG0151	Belongs to the GarS family
LKW27_12620	COG0217	transcriptional regulatory protein
LKW27_12625	COG0433	COG0433 Predicted ATPase
LKW27_12645	COG0277	FAD linked oxidase domain protein
LKW27_12650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LKW27_12675	COG0625	glutathione transferase activity
LKW27_12690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LKW27_12705	COG0402	S-adenosylhomocysteine deaminase activity
LKW27_12740	COG0484	heat shock protein binding
LKW27_12745	COG1012	belongs to the aldehyde dehydrogenase family
LKW27_12765	COG3284	Transcriptional regulator
LKW27_12775	COG2925	Exonuclease
LKW27_12780	COG2951	lytic endotransglycosylase activity
LKW27_12785	COG0542	response to heat
LKW27_12790	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LKW27_12805	COG1199	ATP-dependent helicase activity
LKW27_12820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LKW27_12825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LKW27_12830	COG0508	dehydrogenase complex catalyzes the overall conversion of
LKW27_12835	COG0567	Dehydrogenase, E1 component
LKW27_12840	COG0628	permease
LKW27_12845	COG5002	protein histidine kinase activity
LKW27_12845	COG5001	Diguanylate cyclase
LKW27_12845	COG3447	MASE1 domain protein
LKW27_12850	COG4172	Belongs to the ABC transporter superfamily
LKW27_12855	COG4239	(ABC) transporter, permease
LKW27_12860	COG4174	ABC transporter (Permease)
LKW27_12865	COG4166	transmembrane transport
LKW27_12875	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LKW27_12995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LKW27_13010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LKW27_13015	COG0077	Prephenate dehydratase
LKW27_13015	COG1605	Chorismate mutase
LKW27_13020	COG0287	Prephenate dehydrogenase
LKW27_13025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LKW27_13035	COG0776	regulation of translation
LKW27_13045	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LKW27_13050	COG2111	Na H antiporter
LKW27_13050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LKW27_13055	COG1006	Multisubunit Na H antiporter MnhC subunit
LKW27_13060	COG0651	ATP synthesis coupled electron transport
LKW27_13070	COG2212	antiporter activity
LKW27_13105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LKW27_13130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LKW27_13135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LKW27_13140	COG0405	Gamma-glutamyltransferase
LKW27_13180	COG3193	protein, possibly involved in utilization of glycolate and propanediol
LKW27_13185	COG0670	Belongs to the BI1 family
LKW27_13195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LKW27_13210	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LKW27_13210	COG0506	proline dehydrogenase activity
LKW27_13210	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LKW27_13220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LKW27_13230	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LKW27_13235	COG4774	siderophore transport
LKW27_13270	COG0494	nUDIX hydrolase
LKW27_13275	COG1278	Cold shock
LKW27_13290	COG0492	ferredoxin-NADP+ reductase activity
LKW27_13295	COG2226	methyltransferase
LKW27_13345	COG3209	COG3209 Rhs family protein
LKW27_13365	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_13410	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LKW27_13450	COG0582	viral genome integration into host DNA
LKW27_13535	COG0582	viral genome integration into host DNA
LKW27_13540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LKW27_13540	COG0519	Catalyzes the synthesis of GMP from XMP
LKW27_13565	COG2914	Belongs to the UPF0125 (RnfH) family
LKW27_13575	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LKW27_13595	COG1024	Enoyl-CoA hydratase
LKW27_13600	COG1253	flavin adenine dinucleotide binding
LKW27_13610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LKW27_13615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LKW27_13620	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LKW27_13625	COG0195	Participates in both transcription termination and antitermination
LKW27_13630	COG0779	Required for maturation of 30S ribosomal subunits
LKW27_13640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LKW27_13640	COG2010	Cytochrome c
LKW27_13705	COG2423	ornithine cyclodeaminase activity
LKW27_13725	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LKW27_13735	COG2885	chlorophyll binding
LKW27_13740	COG0823	Involved in the tonB-independent uptake of proteins
LKW27_13745	COG1132	(ABC) transporter
LKW27_13755	COG0084	hydrolase, TatD family'
LKW27_13770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LKW27_13775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LKW27_13790	COG0657	acetylesterase activity
LKW27_13800	COG1454	alcohol dehydrogenase
LKW27_13815	COG2183	response to ionizing radiation
LKW27_13840	COG2814	Major facilitator Superfamily
LKW27_13845	COG2814	Major facilitator Superfamily
LKW27_13885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LKW27_13900	COG1286	toxin biosynthetic process
LKW27_13910	COG0285	dihydrofolate synthase activity
LKW27_13915	COG1393	Belongs to the ArsC family
LKW27_13925	COG3123	guanosine phosphorylase activity
LKW27_13930	COG0137	argininosuccinate synthase activity
LKW27_13940	COG1666	GTP binding
LKW27_13945	COG3577	Aspartyl protease
LKW27_13955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LKW27_13960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LKW27_13965	COG0667	Aldo Keto reductase
LKW27_13970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LKW27_13980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LKW27_13990	COG0308	aminopeptidase N
LKW27_13995	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LKW27_14005	COG0583	DNA-binding transcription factor activity
LKW27_14010	COG1960	acyl-CoA dehydrogenase activity
LKW27_14015	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_14020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_14025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LKW27_14030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LKW27_14035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LKW27_14040	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LKW27_14045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LKW27_14050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LKW27_14065	COG0750	zinc metalloprotease
LKW27_14070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LKW27_14075	COG0575	Belongs to the CDS family
LKW27_14085	COG0233	cytoplasmic translational termination
LKW27_14090	COG0528	UMP kinase activity
LKW27_14095	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LKW27_14100	COG0052	Belongs to the universal ribosomal protein uS2 family
LKW27_14105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_14110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LKW27_14110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LKW27_14135	COG0789	Transcriptional regulator
LKW27_14165	COG2132	Multicopper oxidase
LKW27_14195	COG3191	aminopeptidase activity
LKW27_14210	COG0488	(ABC) transporter
LKW27_14215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LKW27_14220	COG0513	Belongs to the DEAD box helicase family
LKW27_14230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LKW27_14230	COG4651	solute:proton antiporter activity
LKW27_14260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LKW27_14270	COG2207	Transcriptional regulator
LKW27_14275	COG1012	belongs to the aldehyde dehydrogenase family
LKW27_14315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LKW27_14325	COG2267	carboxylic ester hydrolase activity
LKW27_14345	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_14350	COG0028	Belongs to the TPP enzyme family
LKW27_14355	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_14365	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LKW27_14560	COG5484	DNA packaging
LKW27_14560	COG3728	DNA packaging
LKW27_14595	COG1802	Transcriptional regulator
LKW27_14595	COG4626	Terminase
LKW27_14725	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LKW27_14765	COG0322	excinuclease ABC activity
LKW27_14785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LKW27_14790	COG0601	transmembrane transport
LKW27_14800	COG4172	Belongs to the ABC transporter superfamily
LKW27_14805	COG1446	asparaginase
LKW27_14825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LKW27_14830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_14845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LKW27_14860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LKW27_14865	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
LKW27_14875	COG0693	protein deglycase activity
LKW27_14915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LKW27_14925	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_14945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LKW27_14945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LKW27_14950	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LKW27_14950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LKW27_14955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LKW27_14965	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LKW27_14975	COG0560	Phosphoserine phosphatase
LKW27_14990	COG0583	DNA-binding transcription factor activity
LKW27_14995	COG1959	2 iron, 2 sulfur cluster binding
LKW27_15020	COG0513	Belongs to the DEAD box helicase family
LKW27_15035	COG2900	Belongs to the SlyX family
LKW27_15040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LKW27_15045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LKW27_15065	COG0477	Major facilitator Superfamily
LKW27_15090	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LKW27_15095	COG1492	cobalamin metabolic process
LKW27_15100	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_15135	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LKW27_15140	COG0778	Nitroreductase
LKW27_15145	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LKW27_15150	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LKW27_15155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LKW27_15170	COG1797	cobyrinic acid a,c-diamide synthase activity
LKW27_15175	COG4206	TonB-dependent receptor
LKW27_15195	COG3437	response regulator, receiver
LKW27_15205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LKW27_15210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LKW27_15245	COG3278	Belongs to the heme-copper respiratory oxidase family
LKW27_15255	COG2217	Heavy metal translocating P-type atpase
LKW27_15265	COG0589	response to stress
LKW27_15275	COG0318	PFAM AMP-dependent synthetase and ligase
LKW27_15295	COG1802	Transcriptional regulator
LKW27_15300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LKW27_15315	COG0129	dihydroxy-acid dehydratase activity
LKW27_15325	COG4654	Cytochrome c, class I
LKW27_15345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LKW27_15355	COG4175	Glycine betaine
LKW27_15360	COG4176	ABC-type proline glycine betaine transport system permease component
LKW27_15365	COG2113	Glycine betaine
LKW27_15370	COG2205	protein histidine kinase activity
LKW27_15375	COG0745	RESPONSE REGULATOR receiver
LKW27_15385	COG0114	fumarate hydratase activity
LKW27_15400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LKW27_15405	COG2080	2 iron, 2 sulfur cluster binding
LKW27_15410	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LKW27_15415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LKW27_15420	COG1451	nucleotide metabolic process
LKW27_15485	COG2885	chlorophyll binding
LKW27_15500	COG0631	protein serine/threonine phosphatase activity
LKW27_15530	COG1562	ergosterol biosynthetic process
LKW27_15540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LKW27_15550	COG0544	peptidyl-prolyl cis-trans isomerase activity
LKW27_15555	COG0740	serine-type endopeptidase activity
LKW27_15560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LKW27_15565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LKW27_15590	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LKW27_15595	COG1295	ribonuclease BN
LKW27_15605	COG0277	FAD linked oxidase domain protein
LKW27_15615	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LKW27_15630	COG0708	Exodeoxyribonuclease III
LKW27_15645	COG3852	Histidine kinase
LKW27_15655	COG0174	glutamine synthetase
LKW27_15685	COG1187	pseudouridine synthase activity
LKW27_15715	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LKW27_15720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LKW27_15725	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LKW27_15730	COG0330	HflC and HflK could
LKW27_15735	COG0330	HflC and HflK could
LKW27_15740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LKW27_15745	COG1923	regulation of RNA biosynthetic process
LKW27_15750	COG1160	GTP binding
LKW27_15765	COG0124	histidyl-tRNA synthetase
LKW27_15770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LKW27_15780	COG3063	Type IV pilus biogenesis stability protein PilW
LKW27_15785	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LKW27_15790	COG0105	UTP biosynthetic process
LKW27_15795	COG1187	pseudouridine synthase activity
LKW27_15800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LKW27_15805	COG0564	pseudouridine synthase activity
LKW27_15815	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LKW27_15820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LKW27_15825	COG3321	synthase
LKW27_15825	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_15825	COG0604	alcohol dehydrogenase
LKW27_15835	COG3540	Alkaline phosphatase
LKW27_15840	COG0405	Gamma-glutamyltransferase
LKW27_15845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LKW27_15850	COG3300	MHYT domain
LKW27_15850	COG5001	Diguanylate cyclase
LKW27_15855	COG0358	DNA primase activity
LKW27_15860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LKW27_15865	COG0840	transmembrane signaling receptor activity
LKW27_15910	COG4948	Mandelate Racemase Muconate Lactonizing
LKW27_15915	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_15925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LKW27_15930	COG0583	DNA-binding transcription factor activity
LKW27_15945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_15970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LKW27_15985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LKW27_16010	COG3634	alkyl hydroperoxide reductase activity
LKW27_16055	COG4774	siderophore transport
LKW27_16080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LKW27_16085	COG0657	acetylesterase activity
LKW27_16095	COG4628	conserved protein (DUF2132)
LKW27_16105	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LKW27_16125	COG2308	Evidence 4 Homologs of previously reported genes of
LKW27_16160	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LKW27_16165	COG0840	transmembrane signaling receptor activity
LKW27_16170	COG0840	transmembrane signaling receptor activity
LKW27_16180	COG0741	lytic transglycosylase activity
LKW27_16205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LKW27_16210	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LKW27_16215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LKW27_16230	COG2850	peptidyl-arginine hydroxylation
LKW27_16235	COG1047	Peptidyl-prolyl cis-trans
LKW27_16245	COG0756	dUTP diphosphatase activity
LKW27_16250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LKW27_16255	COG0504	CTP synthase activity
LKW27_16260	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LKW27_16280	COG0148	phosphopyruvate hydratase activity
LKW27_16285	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LKW27_16295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LKW27_16305	COG2833	Protein of unknown function (DUF455)
LKW27_16310	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LKW27_16315	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LKW27_16320	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_16325	COG4974	Belongs to the 'phage' integrase family
LKW27_16355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LKW27_16360	COG0802	atpase or kinase
LKW27_16365	COG0860	N-Acetylmuramoyl-L-alanine amidase
LKW27_16380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LKW27_16385	COG0586	Pfam SNARE associated Golgi protein
LKW27_16390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LKW27_16400	COG0584	glycerophosphoryl diester phosphodiesterase
LKW27_16405	COG2267	carboxylic ester hydrolase activity
LKW27_16410	COG1733	regulation of RNA biosynthetic process
LKW27_16415	COG0702	epimerase
LKW27_16420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LKW27_16425	COG1136	(ABC) transporter
LKW27_16430	COG0071	Belongs to the small heat shock protein (HSP20) family
LKW27_16450	COG0457	Tetratricopeptide repeat
LKW27_16450	COG0463	Glycosyl transferase, family 2
LKW27_16495	COG1132	(ABC) transporter
LKW27_16510	COG1007	ATP synthesis coupled electron transport
LKW27_16525	COG0713	ATP synthesis coupled electron transport
LKW27_16535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LKW27_16540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LKW27_16545	COG1034	ATP synthesis coupled electron transport
LKW27_16550	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LKW27_16555	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LKW27_16560	COG0649	NAD binding
LKW27_16565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LKW27_16570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LKW27_16575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LKW27_16590	COG0149	triose-phosphate isomerase activity
LKW27_16595	COG0604	alcohol dehydrogenase
LKW27_16595	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_16595	COG3321	synthase
LKW27_16600	COG1185	polyribonucleotide nucleotidyltransferase activity
LKW27_16605	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LKW27_16610	COG0436	Aminotransferase
LKW27_16620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LKW27_16625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LKW27_16635	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LKW27_16655	COG0542	response to heat
LKW27_16660	COG0314	molybdopterin synthase activity
LKW27_16685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LKW27_16690	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LKW27_16695	COG0303	'Molybdopterin
LKW27_16700	COG1763	Mo-molybdopterin cofactor biosynthetic process
LKW27_16715	COG0436	Aminotransferase
LKW27_16720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LKW27_16785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LKW27_16790	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LKW27_16805	COG0359	binds to the 23S rRNA
LKW27_16810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LKW27_16820	COG0360	Binds together with S18 to 16S ribosomal RNA
LKW27_16825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LKW27_16830	COG0443	Heat shock 70 kDa protein
LKW27_16835	COG0484	heat shock protein binding
LKW27_16845	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LKW27_16855	COG0066	3-isopropylmalate dehydratase activity
LKW27_16860	COG0473	3-isopropylmalate dehydrogenase activity
LKW27_16870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LKW27_16880	COG0101	tRNA pseudouridine synthase activity
LKW27_16885	COG0135	phosphoribosylanthranilate isomerase activity
LKW27_16890	COG0133	tryptophan synthase activity
LKW27_16895	COG0159	tryptophan synthase activity
LKW27_16900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LKW27_16905	COG0762	integral membrane protein
LKW27_16920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LKW27_16945	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LKW27_16950	COG2203	Gaf domain
LKW27_16950	COG3706	GGDEF domain
LKW27_16950	COG4251	negative regulation of phosphorylation
LKW27_16950	COG5001	Diguanylate cyclase
LKW27_16960	COG3064	Membrane
LKW27_16965	COG1472	Belongs to the glycosyl hydrolase 3 family
LKW27_16975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LKW27_16980	COG1381	Involved in DNA repair and RecF pathway recombination
LKW27_16985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LKW27_16990	COG0571	ribonuclease III activity
LKW27_17000	COG0681	Belongs to the peptidase S26 family
LKW27_17005	COG0481	GTPase activity
LKW27_17010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LKW27_17035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LKW27_17040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LKW27_17045	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_17050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LKW27_17055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LKW27_17060	COG0416	fatty acid biosynthetic process
LKW27_17065	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LKW27_17070	COG1399	metal-binding, possibly nucleic acid-binding protein
LKW27_17075	COG0424	maF-like protein
LKW27_17080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LKW27_17085	COG0616	signal peptide processing
LKW27_17085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LKW27_17110	COG1530	ribonuclease E activity
LKW27_17115	COG3022	response to hydroperoxide
LKW27_17125	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LKW27_17125	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LKW27_17135	COG0728	peptidoglycan biosynthetic process
LKW27_17140	COG0268	Binds directly to 16S ribosomal RNA
LKW27_17145	COG0579	oxidoreductase
LKW27_17155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LKW27_17160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LKW27_17185	COG0727	PFAM Uncharacterised protein family (UPF0153)
LKW27_17190	COG1522	sequence-specific DNA binding
LKW27_17195	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LKW27_17205	COG3483	tryptophan 2,3-dioxygenase activity
LKW27_17235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LKW27_17240	COG2916	Histone family protein nucleoid-structuring protein H-NS
LKW27_17245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LKW27_17250	COG0513	Belongs to the DEAD box helicase family
LKW27_17255	COG2321	neutral zinc metallopeptidase
LKW27_17270	COG0717	Belongs to the dCTP deaminase family
LKW27_17285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LKW27_17290	COG2366	antibiotic biosynthetic process
LKW27_17305	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LKW27_17330	COG4603	Belongs to the binding-protein-dependent transport system permease family
LKW27_17335	COG3845	ABC transporter
LKW27_17355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LKW27_17370	COG3447	MASE1 domain protein
LKW27_17370	COG5001	Diguanylate cyclase
LKW27_17370	COG5002	protein histidine kinase activity
LKW27_17390	COG0251	oxidation-reduction process
LKW27_17430	COG0405	Gamma-glutamyltransferase
LKW27_17440	COG2186	Transcriptional regulator
LKW27_17455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LKW27_17485	COG1301	dicarboxylic acid transport
LKW27_17490	COG0840	transmembrane signaling receptor activity
LKW27_17495	COG2186	Transcriptional regulator
LKW27_17500	COG1953	Uracil, thiamine, allantoin
LKW27_17520	COG0280	phosphate acetyltransferase
LKW27_17520	COG0281	malic enzyme
LKW27_17535	COG1116	anion transmembrane transporter activity
LKW27_17540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LKW27_17565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LKW27_17585	COG0829	nickel cation binding
LKW27_17590	COG0840	transmembrane signaling receptor activity
LKW27_17595	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_17650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LKW27_17655	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LKW27_17665	COG0084	hydrolase, TatD family'
LKW27_17670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LKW27_17675	COG0714	Associated with various cellular activities
LKW27_17695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LKW27_17720	COG0805	protein transport
LKW27_17725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LKW27_17730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LKW27_17735	COG0537	adenosine 5'-monophosphoramidase activity
LKW27_17750	COG0140	phosphoribosyl-ATP diphosphatase activity
LKW27_17755	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LKW27_17760	COG0107	imidazoleglycerol-phosphate synthase activity
LKW27_17770	COG1301	dicarboxylic acid transport
LKW27_17775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LKW27_17805	COG0438	transferase activity, transferring glycosyl groups
LKW27_17825	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LKW27_17835	COG0131	Imidazoleglycerol-phosphate dehydratase
LKW27_17840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LKW27_17870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LKW27_17875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LKW27_17880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LKW27_17885	COG5007	Belongs to the BolA IbaG family
LKW27_17890	COG0842	Transport permease protein
LKW27_17895	COG1131	(ABC) transporter
LKW27_17915	COG2853	Lipoprotein
LKW27_17920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LKW27_17925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LKW27_17930	COG1127	ABC transporter
LKW27_17935	COG1126	abc transporter atp-binding protein
LKW27_17940	COG0765	amino acid transport
LKW27_17945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LKW27_17955	COG0067	glutamate synthase
LKW27_17955	COG0069	glutamate synthase activity
LKW27_17955	COG0070	glutamate synthase
LKW27_17975	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LKW27_17980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LKW27_17985	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LKW27_18025	COG1965	Belongs to the frataxin family
LKW27_18055	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LKW27_18060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LKW27_18065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LKW27_18070	COG1333	cytochrome c biogenesis protein
LKW27_18080	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LKW27_18090	COG1560	Kdo2-lipid A biosynthetic process
LKW27_18100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LKW27_18115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LKW27_18120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LKW27_18120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LKW27_18155	COG1953	Uracil, thiamine, allantoin
LKW27_18165	COG0493	'glutamate synthase
LKW27_18170	COG1309	transcriptional regulator
LKW27_18180	COG1216	Glycosyl transferase, family 2
LKW27_18200	COG0367	asparagine synthase
LKW27_18205	COG0438	transferase activity, transferring glycosyl groups
LKW27_18210	COG0367	asparagine synthase
LKW27_18220	COG0438	transferase activity, transferring glycosyl groups
LKW27_18225	COG2226	methyltransferase
LKW27_18260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LKW27_18275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LKW27_18280	COG0459	protein refolding
LKW27_18285	COG0166	Belongs to the GPI family
LKW27_18290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LKW27_18295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LKW27_18305	COG0840	transmembrane signaling receptor activity
LKW27_18310	COG4608	Belongs to the ABC transporter superfamily
LKW27_18315	COG0444	Belongs to the ABC transporter superfamily
LKW27_18320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LKW27_18325	COG0747	negative chemotaxis
LKW27_18330	COG1473	amidohydrolase
LKW27_18350	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LKW27_18355	COG1765	OsmC-like protein
LKW27_18360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LKW27_18365	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LKW27_18385	COG4970	Tfp pilus assembly protein FimT
LKW27_18435	COG1178	ABC-type Fe3 transport system permease component
LKW27_18440	COG3842	ATPase activity
LKW27_18455	COG0540	Belongs to the ATCase OTCase family
LKW27_18460	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LKW27_18465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LKW27_18470	COG1678	Uncharacterized ACR, COG1678
LKW27_18475	COG0415	Belongs to the DNA photolyase family
LKW27_18480	COG0643	Histidine kinase
LKW27_18480	COG2198	Histidine kinase
LKW27_18485	COG0840	transmembrane signaling receptor activity
LKW27_18490	COG0835	chemotaxis
LKW27_18505	COG1773	rubredoxin
LKW27_18510	COG0351	phosphomethylpyrimidine kinase
LKW27_18510	COG0352	thiamine-phosphate diphosphorylase activity
LKW27_18510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LKW27_18515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LKW27_18525	COG0138	bifunctional purine biosynthesis protein purh
LKW27_18530	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LKW27_18535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LKW27_18545	COG1238	metal cluster binding
LKW27_18555	COG0517	IMP dehydrogenase activity
LKW27_18555	COG1125	glycine betaine transport
LKW27_18565	COG0012	GTP binding
LKW27_18570	COG0633	Ferredoxin
LKW27_18570	COG3217	Mosc domain protein beta barrel domain protein
LKW27_18575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LKW27_18590	COG1024	Enoyl-CoA hydratase
LKW27_18595	COG3829	transcription factor binding
LKW27_18600	COG0431	NADPH-dependent FMN reductase
LKW27_18625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LKW27_18630	COG2205	protein histidine kinase activity
LKW27_18640	COG2204	response regulator
LKW27_18650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LKW27_18685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LKW27_18695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LKW27_18705	COG2264	protein methyltransferase activity
LKW27_18710	COG0439	Biotin carboxylase
LKW27_18715	COG0511	ligase activity, forming carbon-carbon bonds
LKW27_18720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LKW27_18730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LKW27_18740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LKW27_18750	COG0312	modulator of DNA gyrase
LKW27_18755	COG0154	amidase activity
LKW27_18760	COG0772	Belongs to the SEDS family
LKW27_18765	COG3150	esterase
LKW27_18775	COG0557	exoribonuclease II activity
LKW27_18785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LKW27_18790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LKW27_18795	COG1414	Transcriptional regulator
LKW27_18820	COG0575	Belongs to the CDS family
LKW27_18825	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LKW27_18840	COG0840	transmembrane signaling receptor activity
LKW27_18845	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LKW27_18855	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LKW27_18860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LKW27_18870	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LKW27_18875	COG1181	Belongs to the D-alanine--D-alanine ligase family
LKW27_18880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LKW27_18885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LKW27_18890	COG0772	Belongs to the SEDS family
LKW27_18895	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LKW27_18900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LKW27_18905	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LKW27_18910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LKW27_18920	COG3116	cell division
LKW27_18925	COG0275	rRNA processing
LKW27_18930	COG2001	Belongs to the MraZ family
LKW27_18935	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LKW27_18940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LKW27_18955	COG0523	cobalamin synthesis protein
LKW27_18960	COG5001	Diguanylate cyclase
LKW27_18960	COG3447	MASE1 domain protein
LKW27_18960	COG5002	protein histidine kinase activity
LKW27_18980	COG1649	PFAM Uncharacterised BCR, COG1649
LKW27_18985	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LKW27_18995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LKW27_19000	COG0625	glutathione transferase activity
LKW27_19035	COG4269	membrane
LKW27_19050	COG3266	domain, Protein
LKW27_19055	COG3267	Type II secretory pathway component ExeA
LKW27_19055	COG3409	Peptidoglycan-binding domain 1 protein
LKW27_19110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LKW27_19120	COG0519	Catalyzes the synthesis of GMP from XMP
LKW27_19135	COG0840	transmembrane signaling receptor activity
LKW27_19145	COG1473	amidohydrolase
LKW27_19160	COG0243	molybdopterin cofactor binding
LKW27_19200	COG1335	isochorismatase
LKW27_19205	COG1741	Belongs to the pirin family
LKW27_19210	COG0583	DNA-binding transcription factor activity
LKW27_19220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LKW27_19225	COG0129	dihydroxy-acid dehydratase activity
LKW27_19235	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LKW27_19240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LKW27_19300	COG1272	protein, Hemolysin III
LKW27_19345	COG0477	Major facilitator Superfamily
LKW27_19355	COG3945	hemerythrin HHE cation binding domain
LKW27_19370	COG0288	reversible hydration of carbon dioxide
LKW27_19375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LKW27_19380	COG2181	nitrate reductase activity
LKW27_19390	COG1140	nitrate reductase beta subunit
LKW27_19395	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LKW27_19400	COG2223	nitrite transmembrane transporter activity
LKW27_19415	COG4771	TonB-dependent receptor
LKW27_19430	COG2197	response regulator
LKW27_19435	COG3850	Histidine kinase
LKW27_19445	COG1285	pathogenesis
LKW27_19465	COG0583	DNA-binding transcription factor activity
LKW27_19475	COG0277	FAD linked oxidase domain protein
LKW27_19500	COG2733	membrane
LKW27_19525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LKW27_19535	COG2084	Dehydrogenase
LKW27_19540	COG2823	Periplasmic or secreted lipoprotein
LKW27_19545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LKW27_19550	COG0792	nuclease activity
LKW27_19555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LKW27_19560	COG0443	Heat shock 70 kDa protein
LKW27_19570	COG0203	ribosomal protein L17
LKW27_19575	COG0202	RNA polymerase activity
LKW27_19580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LKW27_19585	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LKW27_19590	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LKW27_19595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LKW27_19600	COG0201	protein transport
LKW27_19605	COG0200	Binds to the 23S rRNA
LKW27_19610	COG1841	ribosomal large subunit assembly
LKW27_19615	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LKW27_19620	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LKW27_19625	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LKW27_19630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LKW27_19635	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LKW27_19640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LKW27_19645	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LKW27_19650	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LKW27_19670	COG0395	ABC-type sugar transport system, permease component
LKW27_19680	COG3842	ATPase activity
LKW27_19685	COG3842	ATPase activity
LKW27_19695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LKW27_19710	COG0463	Glycosyl transferase, family 2
LKW27_19725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LKW27_19730	COG0783	Belongs to the Dps family
LKW27_19740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LKW27_19780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LKW27_19785	COG0134	indole-3-glycerol-phosphate synthase activity
LKW27_19795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LKW27_19800	COG1280	lysine exporter protein (LysE YggA)
LKW27_19805	COG0512	Glutamine amidotransferase of anthranilate synthase
LKW27_19830	COG0739	heme binding
LKW27_19830	COG0741	lytic transglycosylase activity
LKW27_19830	COG1196	nuclear chromosome segregation
LKW27_19835	COG0500	methyltransferase
LKW27_19955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LKW27_19960	COG4789	Type iii secretion
LKW27_19975	COG4790	Type iii secretion
LKW27_19980	COG4794	Type iii secretion
LKW27_20000	COG2207	Transcriptional regulator
LKW27_20020	COG0546	phosphoglycolate phosphatase activity
LKW27_20030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LKW27_20035	COG2967	ApaG domain
LKW27_20050	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LKW27_20070	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LKW27_20085	COG0659	secondary active sulfate transmembrane transporter activity
LKW27_20090	COG0653	protein targeting
LKW27_20100	COG4178	(ABC) transporter
LKW27_20120	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LKW27_20125	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LKW27_20130	COG1137	ATPase activity
LKW27_20140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LKW27_20150	COG0018	arginyl-trna synthetase
LKW27_20180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LKW27_20195	COG1942	4-Oxalocrotonate Tautomerase
LKW27_20200	COG2814	Major facilitator Superfamily
LKW27_20205	COG0121	glutamine amidotransferase
LKW27_20285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LKW27_20290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LKW27_20305	COG3245	cytochrome
LKW27_20355	COG1201	RNA secondary structure unwinding
LKW27_20360	COG1793	dna ligase
LKW27_20365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LKW27_20365	COG1793	dna ligase
LKW27_20370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LKW27_20375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LKW27_20380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LKW27_20385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LKW27_20390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LKW27_20395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LKW27_20405	COG0356	it plays a direct role in the translocation of protons across the membrane
LKW27_20415	COG2921	Belongs to the UPF0250 family
LKW27_20420	COG0321	lipoyl(octanoyl) transferase activity
LKW27_20425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LKW27_20445	COG0745	RESPONSE REGULATOR receiver
LKW27_20450	COG2205	protein histidine kinase activity
LKW27_20455	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LKW27_20460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LKW27_20465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LKW27_20480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LKW27_20485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LKW27_20500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LKW27_20510	COG0678	peroxiredoxin activity
LKW27_20515	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LKW27_20520	COG0255	Belongs to the universal ribosomal protein uL29 family
LKW27_20525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LKW27_20530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LKW27_20535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LKW27_20540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LKW27_20545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LKW27_20550	COG0089	rRNA binding
LKW27_20555	COG0088	Forms part of the polypeptide exit tunnel
LKW27_20560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LKW27_20565	COG0051	transcription antitermination factor activity, RNA binding
LKW27_20570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LKW27_20575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LKW27_20580	COG0049	tRNA binding
LKW27_20585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LKW27_20590	COG1686	Belongs to the peptidase S11 family
LKW27_20595	COG2945	thiolester hydrolase activity
LKW27_20610	COG1981	membrane
LKW27_20620	COG0598	Magnesium transport protein CorA
LKW27_20625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LKW27_20625	COG0519	Catalyzes the synthesis of GMP from XMP
LKW27_20630	COG1846	Transcriptional regulator
LKW27_20640	COG1566	PFAM secretion protein HlyD family protein
LKW27_20650	COG0412	Dienelactone hydrolase
LKW27_20655	COG1028	Short-chain dehydrogenase reductase Sdr
LKW27_20660	COG2095	MarC family integral membrane protein
LKW27_20665	COG0745	RESPONSE REGULATOR receiver
LKW27_20670	COG2205	protein histidine kinase activity
LKW27_20675	COG4452	Inner membrane protein CreD
LKW27_20695	COG3237	CsbD-like
LKW27_20720	COG1127	ABC transporter
LKW27_20725	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LKW27_20745	COG1760	l-serine dehydratase
LKW27_20750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LKW27_20755	COG0765	amino acid transport
LKW27_20770	COG0768	penicillin binding
LKW27_20775	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LKW27_20785	COG1077	Cell shape determining protein MreB Mrl
LKW27_20790	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LKW27_20795	COG0154	amidase activity
LKW27_20800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LKW27_20810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LKW27_20815	COG0708	Exodeoxyribonuclease III
LKW27_20825	COG2814	Major facilitator Superfamily
LKW27_20830	COG0583	DNA-binding transcription factor activity
LKW27_20850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LKW27_20855	COG0471	metal ion transport
LKW27_20860	COG0501	Belongs to the peptidase M48B family
LKW27_20880	COG2211	Major facilitator Superfamily
LKW27_20885	COG0745	RESPONSE REGULATOR receiver
LKW27_20895	COG0477	Major facilitator Superfamily
LKW27_20915	COG1215	transferase activity, transferring glycosyl groups
LKW27_20960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LKW27_20965	COG0625	glutathione transferase activity
LKW27_20985	COG0747	negative chemotaxis
LKW27_20995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LKW27_21000	COG0477	Major facilitator Superfamily
LKW27_21010	COG0386	Belongs to the glutathione peroxidase family
LKW27_21040	COG0247	lactate metabolic process
LKW27_21050	COG0277	FAD linked oxidase domain protein
LKW27_21095	COG0004	ammonium transporteR
LKW27_21100	COG0347	Belongs to the P(II) protein family
LKW27_21110	COG0606	chelatase, subunit chli
LKW27_21120	COG4191	Histidine kinase
LKW27_21125	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_21130	COG0840	transmembrane signaling receptor activity
LKW27_21140	COG0583	DNA-binding transcription factor activity
LKW27_21195	COG1410	methionine synthase
LKW27_21195	COG0646	methionine synthase
LKW27_21220	COG0765	amino acid transport
LKW27_21225	COG0765	amino acid transport
LKW27_21230	COG1126	abc transporter atp-binding protein
LKW27_21235	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
LKW27_21250	COG0583	DNA-binding transcription factor activity
LKW27_21280	COG0583	DNA-binding transcription factor activity
LKW27_21320	COG2326	polyphosphate kinase activity
LKW27_21330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LKW27_21370	COG3181	Tripartite tricarboxylate transporter family receptor
LKW27_21375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LKW27_21390	COG0583	DNA-binding transcription factor activity
LKW27_21425	COG0840	transmembrane signaling receptor activity
LKW27_21480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LKW27_21510	COG2423	ornithine cyclodeaminase activity
LKW27_21520	COG2271	Major facilitator Superfamily
LKW27_21525	COG0625	glutathione transferase activity
LKW27_21545	COG1960	acyl-CoA dehydrogenase activity
LKW27_21555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LKW27_21560	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LKW27_21570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LKW27_21575	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LKW27_21600	COG1309	transcriptional regulator
LKW27_21610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LKW27_21615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LKW27_21630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LKW27_21635	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LKW27_21640	COG2894	cell division
LKW27_21645	COG0850	regulation of cytokinetic process
LKW27_21655	COG1183	phosphatidylcholine synthase activity
LKW27_21665	COG2423	ornithine cyclodeaminase activity
LKW27_21675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LKW27_21685	COG0501	Belongs to the peptidase M48B family
LKW27_21690	COG1414	Transcriptional regulator
LKW27_21715	COG1116	anion transmembrane transporter activity
LKW27_21730	COG0583	DNA-binding transcription factor activity
LKW27_21745	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LKW27_21765	COG2233	PERMEase
LKW27_21780	COG2050	protein possibly involved in aromatic compounds catabolism
LKW27_21785	COG2096	Adenosyltransferase
LKW27_21800	COG0277	FAD linked oxidase domain protein
LKW27_21890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LKW27_21905	COG3411	Ferredoxin
LKW27_21940	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LKW27_21960	COG2272	Belongs to the type-B carboxylesterase lipase family
LKW27_21975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LKW27_21975	COG0546	phosphoglycolate phosphatase activity
LKW27_21980	COG0277	FAD linked oxidase domain protein
LKW27_22000	COG0493	'glutamate synthase
LKW27_22025	COG1192	Involved in chromosome partitioning
LKW27_22030	COG1280	lysine exporter protein (LysE YggA)
LKW27_22035	COG0357	Ribosomal RNA small subunit methyltransferase G
LKW27_22040	COG0445	tRNA wobble uridine modification
LKW27_22060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LKW27_22065	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LKW27_22085	COG0642	Histidine kinase
LKW27_22090	COG0745	RESPONSE REGULATOR receiver
LKW27_22130	COG2217	Heavy metal translocating P-type atpase
LKW27_22140	COG0789	Transcriptional regulator
LKW27_22145	COG0183	Belongs to the thiolase family
LKW27_22170	COG2715	membrane protein required for spore maturation
LKW27_22175	COG2974	May be involved in recombination