locus-tag class description APS58_0002 ENOG4105HDK L-asparaginase APS58_0003 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) APS58_0005 ENOG4105CQ7 ATP-dependent helicase APS58_0007 ENOG4105MWK D-amino acid dehydrogenase, small subunit APS58_0008 ENOG4108EKC n-acetylglutamate synthase APS58_0010 ENOG4105ETT transcriptional Regulator, LysR family APS58_0011 ENOG4105C72 UPF0176 protein APS58_0012 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) APS58_0013 ENOG4108IJ6 ABC transporter APS58_0014 ENOG4105ECW sulfate abc transporter APS58_0015 ENOG4108I5D sulfate abc transporter APS58_0016 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein APS58_0019 ENOG4105EXG Transcriptional regulator APS58_0020 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) APS58_0022 ENOG4105D01 (LipO)protein APS58_0023 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0024 ENOG4108UMI ABC transporter, permease APS58_0025 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) APS58_0027 ENOG4105EQ0 Major Facilitator superfamily APS58_0028 ENOG4105CR8 Transcriptional regulator APS58_0031 ENOG4105ENJ RND efflux system, outer membrane lipoprotein APS58_0032 ENOG4105BZS acriflavin resistance protein APS58_0035 ENOG4105BZU Histidine kinase APS58_0048 ENOG4105FDF Could be involved in DNA repair (By similarity) APS58_0049 ENOG4105DQE DNA ligase APS58_0050 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) APS58_0054 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase APS58_0056 ENOG4107QX3 carboxylase APS58_0057 ENOG4105DJT lAO AO transport system ATPase APS58_0060 ENOG4105DRR Transcriptional regulator, GntR family APS58_0073 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0076 ENOG4105F2I Transposase APS58_0079 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) APS58_0080 ENOG4105BZU Histidine kinase APS58_0083 ENOG4108R3D Electron transport complex APS58_0084 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0086 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) APS58_0087 ENOG4105CZX twitching motility protein APS58_0088 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) APS58_0089 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) APS58_0090 ENOG4105C5H ABC transporter APS58_0091 ENOG4105CHR reductase APS58_0092 ENOG4105CHU acetyl-coa acetyltransferase APS58_0093 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class APS58_0095 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase APS58_0099 ENOG4107TPY serine threonine protein kinase APS58_0100 ENOG4105F87 Dehydratase APS58_0101 ENOG4105BZ4 penicillin-binding protein APS58_0102 ENOG4105DR4 Methyltransferase APS58_0107 ENOG4107QN2 dihydrolipoyl dehydrogenase APS58_0108 ENOG4107QSN dihydrolipoamide acetyltransferase APS58_0109 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) APS58_0110 ENOG4105BZU Histidine kinase APS58_0111 ENOG4108ZXC Two component transcriptional regulator, luxr family APS58_0112 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) APS58_0113 ENOG4105DGW oligopeptidase A APS58_0115 ENOG4105E66 phosphoriboisomerase A APS58_0116 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) APS58_0120 ENOG4105D5U fad dependent oxidoreductase APS58_0121 ENOG41067B5 Histone deacetylase superfamily protein APS58_0124 ENOG4108JDX DNA polymerase iii, epsilon subunit APS58_0125 ENOG4108ZIT Ferredoxin, 2FE-2S APS58_0126 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB APS58_0127 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) APS58_0129 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins APS58_0130 ENOG4105C3J Cysteine desulfurase APS58_0131 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family APS58_0132 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) APS58_0133 ENOG4105CGF Aromatic amino acid aminotransferase APS58_0134 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F APS58_0136 ENOG4105CCT upf0313 protein APS58_0137 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0140 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein APS58_0143 ENOG4105FC8 fad dependent oxidoreductase APS58_0144 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) APS58_0146 ENOG4105BZC d-serine deaminase APS58_0154 ENOG4105VEJ Heat shock protein APS58_0156 ENOG4105BZU Histidine kinase APS58_0168 ENOG4108UKI Enoyl-CoA hydratase APS58_0170 ENOG4105C7R Atpase associated with various cellular activities aaa_3 APS58_0172 ENOG4105F8C transglutaminase domain-containing protein APS58_0173 ENOG4105CVE Lytic murein transglycosylase APS58_0179 ENOG4105ES9 amino acid APS58_0182 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) APS58_0183 ENOG4105CP9 extracellular ligand-binding receptor APS58_0186 ENOG4105I5W Transporter APS58_0188 ENOG4105D7T ABC transporter APS58_0189 ENOG4105NAE bifunctional deaminase-reductase domain protein APS58_0192 ENOG4105VFU Rna-binding protein APS58_0194 ENOG4105C28 cystathionine APS58_0197 ENOG4108Z86 Glutamine amidotransferase APS58_0203 ENOG4105EU0 Major facilitator Superfamily APS58_0206 ENOG4108VYJ response regulator receiver protein APS58_0208 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0209 ENOG4105CBS Chea signal transduction histidine kinase APS58_0213 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) APS58_0214 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor APS58_0215 ENOG4105C1P efflux transporter, rnd family, mfp subunit APS58_0216 ENOG4105BZS acriflavin resistance protein APS58_0217 ENOG4105ENJ RND efflux system, outer membrane lipoprotein APS58_0219 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0220 ENOG4108IFG nitrite reductase, (NAD(P)H) APS58_0222 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) APS58_0223 ENOG4108I0Q anthranilate phosphoribosyltransferase APS58_0224 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) APS58_0225 ENOG4106R7G Glycoside hydrolase family 5 APS58_0227 ENOG41077A9 carbonic anhydrase APS58_0230 ENOG4105CBX hi0933 family APS58_0231 ENOG4108ZHR arsR family transcriptional regulator APS58_0235 ENOG4105VCC 30S ribosomal protein S21 APS58_0236 ENOG4105KTH gatB Yqey APS58_0237 ENOG4108K3A Glutathione S-transferase APS58_0239 ENOG4105EJC lysr family transcriptional regulator APS58_0240 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) APS58_0241 ENOG4105D78 K07001 NTE family protein APS58_0242 ENOG41079KZ Major Facilitator Superfamily APS58_0244 ENOG4105JN3 extra-cytoplasmic solute receptor family protein APS58_0245 ENOG4105CTX dehydratase APS58_0247 ENOG4105CNV Aldolase APS58_0248 ENOG4105CMS peptidase U62, modulator of DNA gyrase APS58_0249 ENOG4105N42 UPF0307 protein APS58_0250 ENOG4108RIR Molybdenum cofactor biosynthesis protein APS58_0251 ENOG4105D7W serine acetyltransferase APS58_0254 ENOG4108IUW ABC transporter APS58_0257 ENOG4105ECY inositol monophosphatase APS58_0261 ENOG4105BZ1 (ABC) transporter APS58_0263 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase APS58_0264 ENOG4105BZU Histidine kinase APS58_0276 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) APS58_0277 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH APS58_0279 ENOG4105CNA YD repeat protein APS58_0280 ENOG4105CS6 Rhs element vgr protein APS58_0284 ENOG4105BZU Histidine kinase APS58_0285 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) APS58_0286 ENOG4105ENJ RND efflux system, outer membrane lipoprotein APS58_0287 ENOG4105BZS acriflavin resistance protein APS58_0291 ENOG4108HRK Histidine kinase APS58_0292 ENOG4108VAC response regulator APS58_0293 ENOG410829K Lysine exporter protein (Lyse ygga) APS58_0297 ENOG4105F4R Transcriptional regulator mode APS58_0299 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein APS58_0300 ENOG4105E0C molybdate abc transporter APS58_0301 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) APS58_0303 ENOG4105C94 Transporter APS58_0304 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) APS58_0305 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) APS58_0306 ENOG4105CG3 alpha amylase, catalytic region APS58_0309 ENOG4105CG6 trap dicarboxylate transporter dctm subunit APS58_0311 ENOG4105CH5 extracellular solute-binding protein, family 7 APS58_0312 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) APS58_0314 ENOG41086K9 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) APS58_0317 ENOG4105KHC sulfurtransferase APS58_0318 ENOG4107T8P acyl-Coa dehydrogenase APS58_0321 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) APS58_0322 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region APS58_0325 ENOG4105DSF transport protein APS58_0327 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) APS58_0328 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) APS58_0332 ENOG4105C5H ABC transporter APS58_0334 ENOG4105D0M Protease HtpX homolog APS58_0335 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) APS58_0336 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase APS58_0339 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) APS58_0340 ENOG4105E09 nadh pyrophosphatase APS58_0341 ENOG4105C6T cysteine synthase APS58_0350 ENOG4105ETT transcriptional Regulator, LysR family APS58_0351 ENOG4105C1G acyl-Coa dehydrogenase APS58_0352 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F APS58_0359 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase APS58_0360 ENOG4105DJ0 Poly(A) Polymerase APS58_0362 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) APS58_0363 ENOG4105CXB phosphoribosylaminoimidazole synthetase APS58_0369 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) APS58_0373 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0374 ENOG4105DMF Dehydrogenase APS58_0376 ENOG4105BZ4 penicillin-binding protein APS58_0377 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0383 ENOG4105JN3 extra-cytoplasmic solute receptor family protein APS58_0384 ENOG4105CH7 arginosuccinase APS58_0385 ENOG4108HRK Histidine kinase APS58_0386 ENOG4108NEV two component transcriptional regulator, LytTR family APS58_0387 ENOG4105CH7 arginosuccinase APS58_0389 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) APS58_0395 ENOG4107RP9 extracellular solute-binding protein, family 3 APS58_0396 ENOG4105MWK D-amino acid dehydrogenase, small subunit APS58_0402 ENOG4105C2M dna polymerase I APS58_0404 ENOG4105CUV Homoserine Kinase APS58_0416 ENOG4105C4R Atp-dependent dna helicase APS58_0421 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) APS58_0432 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family APS58_0433 ENOG4105BZU Histidine kinase APS58_0434 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) APS58_0437 ENOG4105C2C drug resistance transporter, Bcr CflA APS58_0438 ENOG4105BZU Histidine kinase APS58_0439 ENOG4105C1J atp-dependent rna helicase APS58_0440 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) APS58_0442 ENOG41090A4 Pterin carbinolamine dehydratase APS58_0443 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) APS58_0444 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) APS58_0446 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) APS58_0447 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) APS58_0448 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) APS58_0449 ENOG4105K5M 30s ribosomal protein S16 APS58_0452 ENOG4107QXV Phosphate transporter APS58_0453 ENOG4107GRR phosphate transport regulator APS58_0454 ENOG4105UYK outer membrane protein a APS58_0455 ENOG4108IV0 ABC, transporter APS58_0456 ENOG4105C0Z ABC transporter APS58_0457 ENOG4105CF8 branched-chain amino acid ABC transporter, permease APS58_0458 ENOG4105C32 Amino acid ABC transporter (Permease) APS58_0459 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0460 ENOG4105D1H recombination factor protein RarA APS58_0461 ENOG4108RG0 uracil-dna glycosylase APS58_0465 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) APS58_0466 ENOG4105CNU cell division protein FtsK APS58_0467 ENOG4105C3M thioredoxin reductase APS58_0468 ENOG4105KDC 50s ribosomal protein l28 APS58_0469 ENOG4105W0E 50S ribosomal protein L33 APS58_0470 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family APS58_0474 ENOG4108J20 pectate lyase APS58_0477 ENOG4108V3E phosphoribosylglycinamide formyltransferase APS58_0478 ENOG4108YXG UPF0502 protein APS58_0479 ENOG4105X7H acyl-CoA dehydrogenase APS58_0483 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) APS58_0484 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0485 ENOG4105CG6 trap dicarboxylate transporter dctm subunit APS58_0487 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit APS58_0489 ENOG4105DTN riboflavin biosynthesis protein ribF APS58_0491 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) APS58_0494 ENOG4105ETE Transcriptional regulator (LacI family APS58_0496 ENOG4105E0C molybdate abc transporter APS58_0497 ENOG4105D38 putrescine abc transporter APS58_0498 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) APS58_0499 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) APS58_0501 ENOG4105EAM Na Pi-cotransporter APS58_0504 ENOG4107NQ8 LysR family Transcriptional regulator APS58_0507 ENOG4105DHU Bile acid APS58_0511 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein APS58_0512 ENOG4108IPJ Membrane APS58_0521 ENOG4105CNA YD repeat protein APS58_0526 ENOG4105CS6 Rhs element vgr protein APS58_0527 ENOG4105BZU Histidine kinase APS58_0530 ENOG4107TE5 Lipid kinase APS58_0532 ENOG4105F27 Major Facilitator APS58_0536 ENOG4108IV0 ABC, transporter APS58_0537 ENOG4105C0Z ABC transporter APS58_0538 ENOG4105CNN ABC, transporter APS58_0539 ENOG4105C32 Amino acid ABC transporter (Permease) APS58_0541 ENOG4105CK2 sodium dicarboxylate symporter APS58_0542 ENOG41090FM Phosphatase APS58_0546 ENOG4105CPW cytochrome b561 APS58_0551 ENOG4108JIK carboxylase APS58_0552 ENOG4105P4J Allophanate hydrolase, subunit 1 APS58_0553 ENOG4105CFM UPF0317 protein APS58_0554 ENOG4105E7W lamb ycsf family protein APS58_0555 ENOG4107RGD Major Facilitator superfamily APS58_0558 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) APS58_0559 ENOG4106F60 Histidine kinase APS58_0566 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase APS58_0567 ENOG4105BZU Histidine kinase APS58_0568 ENOG4108YZ9 Urea amidohydrolase subunit gamma APS58_0570 ENOG4105KI2 Urea amidohydrolase subunit beta APS58_0571 ENOG4105CQM Urea amidohydrolase subunit alpha APS58_0573 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) APS58_0574 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) APS58_0575 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) APS58_0582 ENOG4108X0B nad(p)h dehydrogenase (quinone) APS58_0588 ENOG4105BZU Histidine kinase APS58_0590 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) APS58_0591 ENOG4106855 Competence protein APS58_0592 ENOG4106855 Competence protein APS58_0597 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) APS58_0606 ENOG4105BZU Histidine kinase APS58_0607 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase APS58_0612 ENOG4105K6V RNA polymerase APS58_0615 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase APS58_0616 ENOG4105EMU Dehydrogenase APS58_0619 ENOG4105CSA Coproporphyrinogen iii oxidase APS58_0620 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) APS58_0624 ENOG4105DSJ YicC domain protein APS58_0625 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) APS58_0626 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) APS58_0627 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) APS58_0628 ENOG4108RRZ Transcription elongation factor GreB APS58_0634 ENOG4105WH1 Two component transcriptional regulator luxr family APS58_0636 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) APS58_0637 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) APS58_0638 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) APS58_0639 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) APS58_0640 ENOG4105CEN a g-specific adenine glycosylase APS58_0642 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) APS58_0645 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) APS58_0647 ENOG4105C5T Phosphoribosyl pyrophosphate synthase APS58_0648 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) APS58_0649 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) APS58_0650 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding APS58_0652 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component APS58_0653 ENOG4105C3U ABC transporter APS58_0654 ENOG4108JQ7 (ABC) transporter APS58_0656 ENOG4105DEF Extracellular solute-binding protein, family 5 APS58_0663 ENOG4105DIQ Transcriptional regulator APS58_0669 ENOG4105EUJ GTP cyclohydrolase i APS58_0670 ENOG4105DZQ phospholipase D Transphosphatidylase APS58_0672 ENOG4108VYJ response regulator receiver protein APS58_0673 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) APS58_0675 ENOG4105C9M aspartyl-trna synthetase APS58_0680 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) APS58_0683 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) APS58_0685 ENOG4105BZU Histidine kinase APS58_0688 ENOG4108JQ1 Dehydrogenase APS58_0689 ENOG4105BZ7 extracellular solute-binding protein family 1 APS58_0690 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component APS58_0692 ENOG4108IJ9 (ABC) transporter APS58_0694 ENOG4107T6V glycerophosphoryl diester phosphodiesterase APS58_0695 ENOG4105EGS Mechanosensitive ion channel APS58_0702 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) APS58_0703 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) APS58_0706 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) APS58_0707 ENOG4105C37 (CBS) domain APS58_0708 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division APS58_0709 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) APS58_0710 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) APS58_0711 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) APS58_0712 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control APS58_0713 ENOG4105K46 50S ribosomal protein l27 APS58_0714 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) APS58_0715 ENOG4105EAH synthase APS58_0717 ENOG4105CH2 amidohydrolase APS58_0720 ENOG4107QHF type ii secretion system protein e APS58_0722 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) APS58_0723 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) APS58_0724 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) APS58_0725 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) APS58_0726 ENOG4105M6F mutator MutT protein APS58_0728 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) APS58_0729 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving APS58_0730 ENOG4105DR5 peptidase APS58_0733 ENOG4105KB2 stringent starvation protein b APS58_0734 ENOG4107MKT Stringent starvation protein a APS58_0735 ENOG4105EIX cytochrome c1 APS58_0736 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) APS58_0737 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) APS58_0738 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) APS58_0739 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) APS58_0740 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) APS58_0741 ENOG4105D60 lipoprotein releasing system transmembrane protein APS58_0743 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) APS58_0744 ENOG4105X1Z Methyltransferase type 12 APS58_0746 ENOG4106UW1 Major Facilitator superfamily APS58_0747 ENOG4105DB7 PHP domain protein APS58_0748 ENOG4107RTD sua5 ycio yrdc ywlc family protein APS58_0749 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0750 ENOG4108Z4T Peptidase M50 APS58_0751 ENOG4105C31 Tryptophanyl-tRNA synthetase APS58_0752 ENOG4105CNA YD repeat protein APS58_0761 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) APS58_0762 ENOG4105IBP Cyclic peptide transporter APS58_0764 ENOG4108V3E phosphoribosylglycinamide formyltransferase APS58_0766 ENOG4105E0K tonB-dependent siderophore receptor APS58_0767 ENOG4105CEY Amp-dependent synthetase and ligase APS58_0780 ENOG4105CFG Acts as a chaperone (By similarity) APS58_0790 ENOG4105CNA YD repeat protein APS58_0791 ENOG4105CS6 Rhs element vgr protein APS58_0792 ENOG4105C1V Peptidase, M16 APS58_0794 ENOG4105DRP amino acid AbC transporter APS58_0795 ENOG4105DRP amino acid AbC transporter APS58_0796 ENOG4106PMH Extracellular solute-binding protein family 3 APS58_0799 ENOG4105C01 Dihydroxy-acid dehydratase APS58_0803 ENOG4105BZU Histidine kinase APS58_0809 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) APS58_0810 ENOG4105C7B Threonine dehydratase APS58_0813 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) APS58_0814 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase APS58_0815 ENOG4105W5Q DNA repair protein (RadC APS58_0819 ENOG4105C98 muts2 protein APS58_0820 ENOG4105E0F Histidine kinase APS58_0821 ENOG4105XJC Two component transcriptional regulator (Winged helix family APS58_0824 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic APS58_0825 ENOG4105CS6 Rhs element vgr protein APS58_0830 ENOG4105CNA YD repeat protein APS58_0833 ENOG4105CMM transposase APS58_0838 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) APS58_0841 ENOG4107QI1 Mate efflux family protein APS58_0842 ENOG4105CEY Amp-dependent synthetase and ligase APS58_0851 ENOG4105DRR Transcriptional regulator, GntR family APS58_0853 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) APS58_0854 ENOG41083Z3 extracellular ligand-binding receptor APS58_0855 ENOG4108IV0 ABC, transporter APS58_0856 ENOG4105C0Z ABC transporter APS58_0857 ENOG4105CF8 branched-chain amino acid ABC transporter, permease APS58_0858 ENOG4105C32 Amino acid ABC transporter (Permease) APS58_0859 ENOG4105DV0 amidase (EC 3.5.1.4 APS58_0860 ENOG4105C26 Dehydrogenase APS58_0861 ENOG4105EXG Transcriptional regulator APS58_0862 ENOG4105CV6 ABC transporter, permease APS58_0864 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) APS58_0865 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit APS58_0866 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0867 ENOG4105FCD Major Facilitator APS58_0871 ENOG4105C7K acetolactate synthase APS58_0872 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) APS58_0878 ENOG4108IYU L-aspartate oxidase APS58_0880 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) APS58_0881 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) APS58_0882 ENOG4107RJX Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) APS58_0883 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase APS58_0888 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) APS58_0889 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase APS58_0890 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) APS58_0891 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) APS58_0892 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase APS58_0893 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) APS58_0895 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) APS58_0896 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) APS58_0897 ENOG4105CN1 protease APS58_0898 ENOG4105D06 uba thif-type nad fad binding protein APS58_0900 ENOG4105WH1 Two component transcriptional regulator luxr family APS58_0901 ENOG4105BZU Histidine kinase APS58_0907 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) APS58_0908 ENOG4106H78 methyltransferase APS58_0912 ENOG4105ERH Fumarylacetoacetate hydrolase APS58_0913 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr APS58_0914 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) APS58_0917 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0918 ENOG4105ECQ AraC Family Transcriptional Regulator APS58_0921 ENOG4107QJQ Mate efflux family protein APS58_0925 ENOG4105CHM Aminotransferase APS58_0926 ENOG4107RCV ABC transporter, permease APS58_0927 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) APS58_0929 ENOG4105DND Transcriptional regulator APS58_0931 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) APS58_0936 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) APS58_0937 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) APS58_0940 ENOG4107QS1 Cytochrome C Oxidase, Subunit III APS58_0945 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) APS58_0946 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) APS58_0947 ENOG41081UC Inherit from COG: Competence protein APS58_0948 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) APS58_0949 ENOG4105CC0 LysR family Transcriptional regulator APS58_0952 ENOG4107SKI cobyrinic Acid a,c-diamide synthase APS58_0953 ENOG410829K Lysine exporter protein (Lyse ygga) APS58_0954 ENOG4105CKD glutathione-regulated potassium-efflux system protein APS58_0955 ENOG4105E0K tonB-dependent siderophore receptor APS58_0959 ENOG4105CPW cytochrome b561 APS58_0960 ENOG4108VHT MarR family transcriptional regulator APS58_0961 ENOG4105C8Q Methyl-accepting chemotaxis APS58_0962 ENOG41079KZ Major Facilitator Superfamily APS58_0963 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding APS58_0964 ENOG4108XHQ (2Fe-2S)-binding domain protein APS58_0966 ENOG4105RE0 Asp Glu hydantoin racemase APS58_0969 ENOG4108UAU isochorismatase APS58_0970 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding APS58_0974 ENOG4105BZP glycoside hydrolase 15-related APS58_0977 ENOG4105CRW Short chain fatty acid transporter APS58_0981 ENOG4105F2Z 3-oxoadipate enol-lactonase APS58_0982 ENOG4105CHU acetyl-coa acetyltransferase APS58_0983 ENOG4107QNJ CoA-transferase subunit B APS58_0985 ENOG4107HP6 Transcriptional regulator APS58_0990 ENOG4106RE7 Cytochrome APS58_0991 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) APS58_1002 ENOG4105DHQ Histidine kinase APS58_1003 ENOG4105XJC Two component transcriptional regulator (Winged helix family APS58_1004 ENOG4105C0H protease APS58_1010 ENOG4105FB9 CRISPR-associated protein APS58_1013 ENOG4105DEN Luciferase family APS58_1014 ENOG4105D7Q type ii secretion system APS58_1019 ENOG4105BZ1 (ABC) transporter APS58_1020 ENOG4107RRY Cyanophycin synthetase APS58_1021 ENOG4105D9M gamma-glutamylcysteine synthetase APS58_1022 ENOG4108RH0 Crea protein APS58_1025 ENOG4105CF1 Alkylated DNA repair protein APS58_1029 ENOG4105CK6 Two component transcriptional regulator (Winged helix family APS58_1030 ENOG4105BZU Histidine kinase APS58_1031 ENOG4107Z5C methylesterase APS58_1032 ENOG4105BZU Histidine kinase APS58_1033 ENOG4105BZU Histidine kinase APS58_1035 ENOG4105BZU Histidine kinase APS58_1040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component APS58_1041 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component APS58_1043 ENOG4105C9U ATP-dependent DNA helicase RecQ APS58_1046 ENOG4105CNA YD repeat protein APS58_1046 ENOG4105CNA YD repeat protein APS58_1047 ENOG4105CS6 Rhs element vgr protein APS58_1050 ENOG4105C7W Xanthine dehydrogenase APS58_1051 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding APS58_1052 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit APS58_1057 ENOG4108RCM Nitroreductase APS58_1060 ENOG4105CGH 5'-nucleotidase APS58_1061 ENOG4105DUM transcriptional regulator, lysR family APS58_1062 ENOG4105HMI Membrane APS58_1065 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) APS58_1071 ENOG4105E5G Alpha beta hydrolase fold APS58_1073 ENOG4105EVH UPF0753 protein APS58_1074 ENOG4108TWJ NADH dehydrogenase subunit 5 APS58_1080 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) APS58_1082 ENOG4105BZU Histidine kinase APS58_1083 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) APS58_1088 ENOG4105ETT transcriptional Regulator, LysR family APS58_1089 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) APS58_1091 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) APS58_1092 ENOG4105C0R drug resistance transporter emrb qaca subfamily APS58_1093 ENOG4108YX9 iron--sulfur cluster insertion protein erpA APS58_1096 ENOG4108UJD 30S ribosomal protein S9 APS58_1097 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) APS58_1098 ENOG4107QPV Serine Threonine protein kinase APS58_1099 ENOG4105D6S protein involved in catabolism of external DNA APS58_1102 ENOG4105SYT Methylenetetrahydrofolate reductase APS58_1104 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) APS58_1106 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) APS58_1112 ENOG4105JN3 extra-cytoplasmic solute receptor family protein APS58_1114 ENOG4105CDA abc transporter atp-binding protein APS58_1115 ENOG4105DRP amino acid AbC transporter APS58_1116 ENOG4105EAD ABC transporter APS58_1117 ENOG4107RP9 extracellular solute-binding protein, family 3 APS58_1118 ENOG4107RP9 extracellular solute-binding protein, family 3 APS58_1119 ENOG4107YNJ LysR family Transcriptional regulator APS58_1120 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter APS58_1121 ENOG4105CG6 trap dicarboxylate transporter dctm subunit APS58_1122 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit APS58_1123 ENOG4108JJ7 ABC transporter APS58_1124 ENOG4105NAU thioesterase Superfamily protein APS58_1127 ENOG41060WC Enoyl-CoA hydratase APS58_1129 ENOG4105CHU acetyl-coa acetyltransferase APS58_1133 ENOG4105CSU acyl-Coa dehydrogenase APS58_1135 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) APS58_1137 ENOG4105XJC Two component transcriptional regulator (Winged helix family APS58_1138 ENOG4105CAS nag kinase APS58_1144 ENOG4105EY8 ABC transporter APS58_1146 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) APS58_1149 ENOG4105GVR general secretion pathway protein D APS58_1156 ENOG4105WMT general secretion pathway protein h APS58_1157 ENOG4108VAU general secretion pathway protein G APS58_1158 ENOG4105D7Q type ii secretion system APS58_1159 ENOG4107QHF type ii secretion system protein e APS58_1161 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase APS58_1163 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase APS58_1167 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) APS58_1168 ENOG4109066 lysm domain bon superfamily protein APS58_1172 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase APS58_1173 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase APS58_1175 ENOG4105C38 Glycyl-tRNA synthetase beta subunit APS58_1176 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit APS58_1177 ENOG4105NQN cytochrome C APS58_1179 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) APS58_1180 ENOG4105HDK L-asparaginase APS58_1182 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) APS58_1183 ENOG4108JU5 Magnesium and cobalt efflux protein APS58_1186 ENOG4108YXU transcriptional regulator AsnC family APS58_1187 ENOG4107IFA Lipase (EC 3.1.1.3) APS58_1191 ENOG4105MIR Phenylalanine 4-monooxygenase APS58_1195 ENOG4105CEY Amp-dependent synthetase and ligase APS58_1196 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator APS58_1197 ENOG4105C2J ABC transporter APS58_1198 ENOG4105CNN ABC, transporter APS58_1199 ENOG4105ETE Transcriptional regulator (LacI family APS58_1200 ENOG4108RVA ribokinase APS58_1201 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) APS58_1204 ENOG4105E4C Lytic transglycosylase catalytic APS58_1205 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase APS58_1206 ENOG4105BZU Histidine kinase APS58_1211 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate APS58_1213 ENOG4108K4C ec 3.1.3.12 APS58_1214 ENOG4105BZP glycoside hydrolase 15-related APS58_1215 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase APS58_1219 ENOG4107RP9 extracellular solute-binding protein, family 3 APS58_1224 ENOG4105VCD cytoplasmic protein APS58_1225 ENOG4105D22 carbon starvation protein APS58_1226 ENOG4105WH1 Two component transcriptional regulator luxr family APS58_1228 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) APS58_1230 ENOG4105CVJ phosphoglycerate mutase APS58_1235 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) APS58_1238 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) APS58_1239 ENOG4105C9A Phoh family APS58_1243 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) APS58_1244 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) APS58_1246 ENOG4105C1J atp-dependent rna helicase APS58_1247 ENOG4105FYV Amp nucleosidase APS58_1248 ENOG4105BZU Histidine kinase APS58_1251 ENOG4105DM4 PTS System APS58_1252 ENOG4105DE4 1-phosphofructokinase APS58_1253 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) APS58_1257 ENOG4105F7F Chaperone APS58_1259 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR APS58_1260 ENOG4105CJ1 ABC, transporter APS58_1262 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase APS58_1264 ENOG4107XC4 flavin reductase domain protein, FMN-binding APS58_1266 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) APS58_1268 ENOG4105ERH Fumarylacetoacetate hydrolase APS58_1271 ENOG4105K56 Transcriptional regulator APS58_1272 ENOG4108ZHJ Organic hydroperoxide resistance protein APS58_1275 ENOG4105D9P serine threonine protein kinase APS58_1277 ENOG4105CK6 Two component transcriptional regulator (Winged helix family APS58_1280 ENOG4105BZU Histidine kinase APS58_1284 ENOG4105CNA YD repeat protein APS58_1290 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) APS58_1293 ENOG4105FE9 pseudouridine synthase APS58_1294 ENOG4105BZU Histidine kinase APS58_1296 ENOG4105C8Q Methyl-accepting chemotaxis APS58_1297 ENOG4107RYR Transcriptional regulator, Crp Fnr family APS58_1300 ENOG4105X23 Endonuclease Exonuclease phosphatase APS58_1301 ENOG4105DZQ phospholipase D Transphosphatidylase APS58_1302 ENOG4107UXM Membrane APS58_1303 ENOG4105DZ0 fad dependent oxidoreductase APS58_1305 ENOG4105C8Q Methyl-accepting chemotaxis APS58_1307 ENOG4105MP9 class II Aldolase APS58_1308 ENOG4105C10 Electron transfer flavoprotein APS58_1309 ENOG4105BZJ Electron transfer flavoprotein APS58_1312 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F APS58_1313 ENOG4105E39 Enoyl-CoA hydratase APS58_1314 ENOG4105C1G acyl-Coa dehydrogenase APS58_1315 ENOG4105CC9 acyl-Coa dehydrogenase APS58_1316 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase APS58_1317 ENOG4105CC0 LysR family Transcriptional regulator APS58_1318 ENOG4105D0M Protease HtpX homolog APS58_1321 ENOG4105EKE dihydroorotase APS58_1322 ENOG4105EB3 Histidine kinase APS58_1323 ENOG4105CK6 Two component transcriptional regulator (Winged helix family APS58_1326 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) APS58_1327 ENOG4105C42 Type I secretion membrane fusion protein (HlyD APS58_1332 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase APS58_1335 ENOG4108JPW Aminotransferase APS58_1341 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) APS58_1344 ENOG4108Z9W Outer membrane porin APS58_1345 ENOG4108Z9W Outer membrane porin APS58_1346 ENOG4105CSH Transporter APS58_1350 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase APS58_1351 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase APS58_1354 ENOG4108IPT Naphthoate synthase APS58_1355 ENOG4107QX3 carboxylase APS58_1356 ENOG4105CEY Amp-dependent synthetase and ligase APS58_1360 ENOG4107YBY Hydrolase APS58_1361 ENOG4105BZU Histidine kinase APS58_1362 ENOG4105K5B UPF0225 protein APS58_1364 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) APS58_1365 ENOG4105C1G acyl-Coa dehydrogenase APS58_1368 ENOG4105CHU acetyl-coa acetyltransferase APS58_1369 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) APS58_1370 ENOG41077A9 carbonic anhydrase APS58_1371 ENOG4105C1G acyl-Coa dehydrogenase APS58_1373 ENOG4108Z6Z Transcriptional regulator APS58_1379 ENOG4105C5H ABC transporter APS58_1380 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) APS58_1381 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) APS58_1382 ENOG4105BZU Histidine kinase APS58_1383 ENOG4108V3W Chemotaxis protein, CheW APS58_1384 ENOG4105CBS Chea signal transduction histidine kinase APS58_1385 ENOG4108VYJ response regulator receiver protein APS58_1387 ENOG4105BZU Histidine kinase APS58_1388 ENOG4105WH1 Two component transcriptional regulator luxr family APS58_1389 ENOG4105D19 Role in flagellar biosynthesis (By similarity) APS58_1390 ENOG4105VS8 Flagellar biosynthetic protein fliq APS58_1391 ENOG4105CN7 Flagellar biosynthetic protein FliP APS58_1393 ENOG4105DD5 Flagellar motor switch protein APS58_1394 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) APS58_1395 ENOG4107ZI8 flagellar basal body-associated protein flil APS58_1398 ENOG4108JIR Flagellum-specific ATP synthase APS58_1400 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) APS58_1401 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) APS58_1402 ENOG4105VQ0 flagellar hook-basal body complex protein fliE APS58_1404 ENOG4105MQ3 flagellar protein FliS APS58_1405 ENOG4105DTS flagellar hook-associated APS58_1411 ENOG4105MWK D-amino acid dehydrogenase, small subunit APS58_1412 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase APS58_1414 ENOG4107RD7 Flagellar Motor Protein, MotA APS58_1415 ENOG4105ER2 Ompa motb domain protein APS58_1416 ENOG4108VYJ response regulator receiver protein APS58_1417 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) APS58_1418 ENOG4105D00 flagellar biosynthetic protein flhB APS58_1419 ENOG4105D7B Flagellar biosynthesis protein flha APS58_1420 ENOG4105FZW flagellar biosynthesis regulator FlhF APS58_1422 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) APS58_1426 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) APS58_1427 ENOG4108ZC9 flagellar basal-body rod protein flgc APS58_1428 ENOG4105W00 Flagellar hook capping protein APS58_1429 ENOG4105BZE flagellar hook protein, FlgE APS58_1430 ENOG4108KPB Flagellar basal-body rod protein FlgF APS58_1431 ENOG4105CGA flagellar basal-body rod protein FlgG APS58_1434 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) APS58_1435 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj APS58_1436 ENOG4105E1Q flagellar hook-associated protein APS58_1437 ENOG4105DTJ flagellar hook-associated protein APS58_1440 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family APS58_1442 ENOG4105T38 integral membrane protein APS58_1443 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family APS58_1444 ENOG4108TGY Glutathione S-transferase APS58_1445 ENOG4105JAB phenazine biosynthesis protein, phzf family APS58_1453 ENOG4105C8Q Methyl-accepting chemotaxis APS58_1464 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) APS58_1471 ENOG4105DU1 integral membrane protein, terc APS58_1472 ENOG41063Z6 transcriptional regulator, lysR family APS58_1477 ENOG41061MV Arylsulfatase APS58_1478 ENOG4105JN3 extra-cytoplasmic solute receptor family protein APS58_1480 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) APS58_1481 ENOG4105C25 Primosomal protein n' APS58_1485 ENOG4105C4R Atp-dependent dna helicase APS58_1486 ENOG4105HDD phospholipase APS58_1489 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) APS58_1496 ENOG4105CYX Short-chain dehydrogenase reductase Sdr APS58_1502 ENOG4105K6H D-cysteine desulfhydrase APS58_1504 ENOG4105C8Q Methyl-accepting chemotaxis APS58_1513 ENOG4105E1J oxidoreductase APS58_1515 ENOG4105MWK D-amino acid dehydrogenase, small subunit APS58_1519 ENOG4105M2Z protein tyrosine serine phosphatase APS58_1520 ENOG4105CHR reductase APS58_1522 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component APS58_1523 ENOG4105D7T ABC transporter APS58_1526 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein APS58_1532 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) APS58_1536 ENOG4105ES5 Histidine kinase APS58_1538 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B APS58_1540 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) APS58_1541 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) APS58_1542 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) APS58_1543 ENOG4108VZM 50s ribosomal protein L10 APS58_1545 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) APS58_1546 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) APS58_1547 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) APS58_1548 ENOG4105PM1 preprotein translocase subunit SecE APS58_1550 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) APS58_1559 ENOG4105D7Z glutathione synthase APS58_1560 ENOG4105DKK Benzoate APS58_1561 ENOG4105DFH Transport of potassium into the cell (By similarity) APS58_1563 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) APS58_1564 ENOG4105C1A potassium transporter peripheral membrane APS58_1565 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) APS58_1569 ENOG4105C8T Leucyl-tRNA synthetase APS58_1571 ENOG4105BZU Histidine kinase APS58_1572 ENOG4105SG9 biopolymer transport protein, ExbD APS58_1574 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) APS58_1575 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) APS58_1576 ENOG41090R7 Ferric uptake APS58_1577 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) APS58_1578 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN APS58_1579 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA APS58_1580 ENOG4105C8V SAICAR synthetase APS58_1582 ENOG4105K63 Thioredoxin APS58_1583 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) APS58_1584 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit APS58_1585 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) APS58_1590 ENOG41072GX Peptidase M22 Glycoprotease APS58_1593 ENOG4107QUT magnesium and cobalt transport protein CorA APS58_1595 ENOG4105CEY Amp-dependent synthetase and ligase APS58_1597 ENOG4105D2N Aldolase APS58_1599 ENOG4105XJC Two component transcriptional regulator (Winged helix family APS58_1602 ENOG4105CA9 Pyruvate kinase APS58_1603 ENOG4107RAQ aminopeptidase APS58_1604 ENOG4108S0S Nucleotidyl transferase APS58_1605 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) APS58_1606 ENOG4105CV1 Transketolase (EC 2.2.1.1) APS58_1610 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase APS58_1614 ENOG4105CDV Ompa motb domain protein APS58_1626 ENOG4105EUB pirin domain protein APS58_1630 ENOG4105D64 Mechanosensitive ion channel APS58_1633 ENOG4107JEE Short-chain dehydrogenase reductase Sdr APS58_1637 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase APS58_1647 ENOG4105HHM rdd domain containing protein APS58_1653 ENOG4105C9U ATP-dependent DNA helicase RecQ APS58_1655 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase APS58_1661 ENOG4105DUM transcriptional regulator, lysR family APS58_1663 ENOG4105DHQ Histidine kinase APS58_1666 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) APS58_1667 ENOG4108004 Modulates RecA activity (By similarity) APS58_1669 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) APS58_1670 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) APS58_1671 ENOG4105VIE preprotein translocase, subunit YajC APS58_1673 ENOG4105F7P transcriptional regulator AsnC family APS58_1675 ENOG4107SFI Major Facilitator superfamily APS58_1679 ENOG4105CA3 membrane-bound lytic murein transglycosylase APS58_1683 ENOG4105BZU Histidine kinase APS58_1686 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) APS58_1687 ENOG4105CEY Amp-dependent synthetase and ligase APS58_1690 ENOG4108IG5 Transcriptional regulator APS58_1695 ENOG4105CPI Metal Dependent Phosphohydrolase APS58_1697 ENOG4108U78 Glutathione S-transferase APS58_1698 ENOG4107QTF adenylosuccinate lyase APS58_1699 ENOG4108VWS Yaeq family APS58_1702 ENOG4108ZCF integral membrane protein APS58_1704 ENOG41086DT Membrane protein of unknown function APS58_1705 ENOG4105ERG peptidase m48, ste24p APS58_1706 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) APS58_1707 ENOG4105YWY APS58_1708 ENOG4108YSG O-Antigen polymerase APS58_1709 ENOG4108ZUW Major pilin subunit APS58_1710 ENOG4105Q36 FHA domain containing protein APS58_1712 ENOG4108ZCF integral membrane protein APS58_1713 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha APS58_1714 ENOG4105CMV Succinyl-CoA synthetase subunit beta APS58_1715 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase APS58_1716 ENOG4105C79 DNA protecting protein DprA APS58_1718 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) APS58_1720 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) APS58_1723 ENOG4105BZA Phosphoglycerate kinase APS58_1725 ENOG4108594 Permease of the drug metabolite transporter APS58_1726 ENOG4105SKN orotidine 5''-phosphate decarboxylase APS58_1732 ENOG4108594 Permease of the drug metabolite transporter APS58_1733 ENOG4105C8Q Methyl-accepting chemotaxis APS58_1739 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) APS58_1741 ENOG4107RDB Major Facilitator APS58_1743 ENOG4108UUM single-stranded DNA-binding protein APS58_1749 ENOG41080HT Transcriptional regulator, arsr family APS58_1755 ENOG4105DAA L-lactate APS58_1756 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) APS58_1762 ENOG4105BZU Histidine kinase APS58_1763 ENOG4108R6K riboflavin synthase, subunit alpha APS58_1769 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) APS58_1777 ENOG4105EVZ LysR family transcriptional regulator APS58_1778 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) APS58_1780 ENOG4105C26 Dehydrogenase APS58_1782 ENOG4105BZU Histidine kinase APS58_1783 ENOG4108PVQ transcriptional regulator APS58_1785 ENOG4105C32 Amino acid ABC transporter (Permease) APS58_1786 ENOG4105CF8 branched-chain amino acid ABC transporter, permease APS58_1787 ENOG4105C0Z ABC transporter APS58_1788 ENOG4108IV0 ABC, transporter APS58_1789 ENOG4105CE7 Amidase, hydantoinase carbamoylase family APS58_1793 ENOG4105C6K Malic enzyme APS58_1796 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) APS58_1797 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) APS58_1798 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) APS58_1799 ENOG4105EHM Aminoglycoside phosphotransferase APS58_1800 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) APS58_1803 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) APS58_1805 ENOG4105DXI Major Facilitator superfamily APS58_1807 ENOG4108K3Z AraC family transcriptional regulator APS58_1808 ENOG4105C85 amino acid APS58_1809 ENOG4105CPD ethanolamine ammonia-lyase APS58_1810 ENOG4107FQ9 ethanolamine ammonia-lyase APS58_1811 ENOG4105BZU Histidine kinase APS58_1812 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) APS58_1813 ENOG4105DWV Homoserine O-trans-acetylase APS58_1815 ENOG4105VFU Rna-binding protein APS58_1816 ENOG4105VFU Rna-binding protein APS58_1817 ENOG4107FW0 short-chain dehydrogenase reductase APS58_1819 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase APS58_1820 ENOG4105C2X Arabinose 5-phosphate isomerase APS58_1822 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) APS58_1823 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) APS58_1826 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) APS58_1828 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins APS58_1829 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) APS58_1830 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) APS58_1831 ENOG4105VG0 50S ribosomal protein l34 APS58_1832 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) APS58_1833 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) APS58_1834 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) APS58_1843 ENOG4108Z9K Osmotically inducible protein APS58_1845 ENOG4105D6E homoserine dehydrogenase APS58_1847 ENOG4105DVT helicase APS58_1850 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) APS58_1851 ENOG4105CSW GntR family transcriptional regulator APS58_1853 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) APS58_1854 ENOG4105K4H Nlp p60 protein APS58_1855 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) APS58_1856 ENOG4105BZU Histidine kinase APS58_1859 ENOG4105DH7 May be involved in recombination (By similarity) APS58_1860 ENOG4108JIC nucleoside recognition domain protein APS58_1865 ENOG4105CHU acetyl-coa acetyltransferase APS58_1868 ENOG4105C59 p-type ATPase APS58_1869 ENOG4105C8Q Methyl-accepting chemotaxis APS58_1875 ENOG4105ETX regulatoR APS58_1876 ENOG4105ECM Sensor protein basS pmrB APS58_1879 ENOG4106FTQ Taurine ABC transporter, periplasmic APS58_1880 ENOG4108IY8 ABC, transporter APS58_1881 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component APS58_1882 ENOG4108K3A Glutathione S-transferase APS58_1883 ENOG4105KRS Proteinase inhibitor APS58_1885 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) APS58_1886 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) APS58_1887 ENOG4108NIW Leucine export protein LeuE APS58_1888 ENOG4107QJE Chromosome Partitioning Protein APS58_1893 ENOG4105BZ8 glutamate synthase APS58_1898 ENOG4105IQ5 FAD linked oxidase domain protein APS58_1902 ENOG4105EBR Carboxylesterase APS58_1903 ENOG4105CIA precorrin-4 C(11)-methyltransferase APS58_1904 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein APS58_1905 ENOG41081F0 Precorrin-8x methylmutase APS58_1906 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) APS58_1907 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase APS58_1909 ENOG4108P62 biosynthesis protein (CbiG) APS58_1912 ENOG4105E4R Precorrin-3B C17-methyltransferase APS58_1913 ENOG4105NZG Ferredoxin APS58_1916 ENOG4107XWI flavin reductase domain protein, FMN-binding APS58_1921 ENOG4106TQH Potential cysteine protease, which may play a central role after invasion of host cell (By similarity) APS58_1933 ENOG4105CQB FAD linked oxidase domain protein APS58_1936 ENOG4108WBT adenosyltransferase APS58_1937 ENOG4105KA0 thioesterase Superfamily protein APS58_1940 ENOG4105C2W permease APS58_1942 ENOG4105C8Q Methyl-accepting chemotaxis APS58_1944 ENOG4108Z0R Transferase APS58_1952 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component APS58_1957 ENOG4108K0D peptidase, M48 APS58_1959 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) APS58_1963 ENOG4107QWB Ornithine cyclodeaminase APS58_1965 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase APS58_1967 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) APS58_1968 ENOG4107QMS site-determining protein APS58_1969 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) APS58_1973 ENOG41081R7 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) APS58_1974 ENOG4105MWK D-amino acid dehydrogenase, small subunit APS58_1981 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) APS58_1982 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) APS58_1984 ENOG4105DJ9 glucan biosynthesis protein APS58_1985 ENOG4105C7B Threonine dehydratase APS58_1987 ENOG4105CSU acyl-Coa dehydrogenase APS58_1991 ENOG4108RXX maleylacetoacetate isomerase APS58_2000 ENOG4105C0D helicase APS58_2011 ENOG4105C8Q Methyl-accepting chemotaxis APS58_2016 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family APS58_2017 ENOG4107TUY Histidine kinase APS58_2018 ENOG4105C3R Methionine synthase APS58_2019 ENOG4106NZI LysR family Transcriptional regulator APS58_2024 ENOG4105C9U ATP-dependent DNA helicase RecQ APS58_2032 ENOG4105D82 Glutamate dehydrogenase APS58_2034 ENOG4105CSR polyphosphate kinase 2 APS58_2039 ENOG4108MP6 LysR family Transcriptional regulator APS58_2042 ENOG4105DND Transcriptional regulator APS58_2047 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) APS58_2048 ENOG4107RP9 extracellular solute-binding protein, family 3 APS58_2051 ENOG4105CDA abc transporter atp-binding protein APS58_2052 ENOG4105E5Q amino acid AbC transporter APS58_2053 ENOG4105E5Q amino acid AbC transporter APS58_2058 ENOG4105C3R Methionine synthase APS58_2062 ENOG4105HSS phospholipase C APS58_2063 ENOG4105BZU Histidine kinase APS58_2067 ENOG4105DP0 ferredoxin-NADP reductase APS58_2068 ENOG4105CBN LysR family transcriptional regulator APS58_2071 ENOG4105C8Q Methyl-accepting chemotaxis APS58_2074 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family APS58_2075 ENOG4105C0P Mg chelatase subunit ChlI APS58_2078 ENOG4105BZU Histidine kinase APS58_2086 ENOG4105CS6 Rhs element vgr protein APS58_2087 ENOG4105EU8 FAD linked oxidase domain protein APS58_2089 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) APS58_2097 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) APS58_2098 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) APS58_2100 ENOG4105DEF Extracellular solute-binding protein, family 5 APS58_2104 ENOG4108K3A Glutathione S-transferase APS58_2105 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) APS58_2107 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) APS58_2109 ENOG4105CM2 brancheD-chain amino acid aminotransferase APS58_2117 ENOG4105EGI Transcriptional regulator APS58_2118 ENOG4105CBP Major Facilitator APS58_2119 ENOG4105E0F Histidine kinase APS58_2120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family APS58_2121 ENOG4105EYM Major Facilitator superfamily APS58_2125 ENOG4105D0M Protease HtpX homolog APS58_2126 ENOG4107QPK )-transporter APS58_2127 ENOG4105C5X domain protein APS58_2131 ENOG4105HEI LysR family (Transcriptional regulator APS58_2132 ENOG4105F27 Major Facilitator APS58_2133 ENOG4105CV8 reductase APS58_2134 ENOG4105CGK Exodeoxyribonuclease III APS58_2135 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) APS58_2137 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) APS58_2138 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) APS58_2139 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) APS58_2140 ENOG4105DFF Rod shape-determining protein mreb APS58_2142 ENOG4105VQ7 Rod shape-determining protein MreD APS58_2143 ENOG4105CJN penicillin-binding protein APS58_2146 ENOG4105E5Q amino acid AbC transporter APS58_2147 ENOG4105EAB amino acid AbC transporter APS58_2148 ENOG4105EJQ L-serine dehydratase APS58_2149 ENOG4105JQN Transcriptional regulator APS58_2153 ENOG4105DHJ ABC, transporter APS58_2158 ENOG4105VDW Csbd family APS58_2162 ENOG4105CT7 inner membrane cred family protein APS58_2163 ENOG4105EB3 Histidine kinase APS58_2164 ENOG4105E3W Two component transcriptional regulator (Winged helix family APS58_2165 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein APS58_2166 ENOG4105CYX Short-chain dehydrogenase reductase Sdr APS58_2168 ENOG4105C0R drug resistance transporter emrb qaca subfamily APS58_2169 ENOG4105CW7 secretion protein, HlyD family APS58_2170 ENOG4105ETP RND efflux system, outer membrane lipoprotein APS58_2171 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes APS58_2172 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) APS58_2173 ENOG4105D7N magnesium and cobalt transport protein CorA APS58_2174 ENOG4105D52 delta-aminolevulinic acid dehydratase APS58_2175 ENOG4108YXA Membrane APS58_2178 ENOG4105DHZ alpha beta APS58_2179 ENOG4105DZ1 carboxypeptidase APS58_2180 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) APS58_2181 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) APS58_2182 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) APS58_2183 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) APS58_2184 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) APS58_2185 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) APS58_2186 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) APS58_2187 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) APS58_2188 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity APS58_2189 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) APS58_2190 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) APS58_2191 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) APS58_2192 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) APS58_2193 ENOG41084PQ 50s ribosomal protein l29 APS58_2194 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal APS58_2197 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen APS58_2200 ENOG41080Z8 PHOSPHOCARRIER protein APS58_2201 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) APS58_2205 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) APS58_2206 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) APS58_2207 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) APS58_2208 ENOG4105C08 Histidine kinase APS58_2209 ENOG4105EEX Two component transcriptional regulator (Winged helix family APS58_2212 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) APS58_2213 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) APS58_2214 ENOG4108Z43 UPF0250 protein APS58_2216 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) APS58_2217 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) APS58_2218 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) APS58_2219 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) APS58_2220 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) APS58_2221 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) APS58_2222 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) APS58_2223 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) APS58_2225 ENOG4107T0X DNA ligase APS58_2226 ENOG4107QRT dEAD DEAH box helicase APS58_2236 ENOG4105MPD Cytochrome APS58_2238 ENOG4105ENJ RND efflux system, outer membrane lipoprotein APS58_2239 ENOG4105BZS acriflavin resistance protein APS58_2240 ENOG4105C1P efflux transporter, rnd family, mfp subunit APS58_2257 ENOG4105E7A Glutamine amidotransferase APS58_2258 ENOG4105C0R drug resistance transporter emrb qaca subfamily APS58_2259 ENOG41084KP 4-oxalocrotonate tautomerase APS58_2261 ENOG4105C8Q Methyl-accepting chemotaxis APS58_2262 ENOG4107QP3 malate synthase g APS58_2265 ENOG4105DZG Dehydrogenase APS58_2268 ENOG4105C75 arginyL-tRNA synthetase APS58_2270 ENOG4108Z33 Thiol disulfide Interchange Protein APS58_2272 ENOG4108IUZ ABC transporter APS58_2273 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) APS58_2274 ENOG4105KAV tspo and mbr like protein APS58_2275 ENOG4105C8Q Methyl-accepting chemotaxis APS58_2276 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) APS58_2280 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving APS58_2281 ENOG4105CHH sulfate transporter APS58_2282 ENOG4105C8Q Methyl-accepting chemotaxis APS58_2284 ENOG4108ZAI phosphatidylglycerophosphatase a APS58_2286 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) APS58_2288 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) APS58_2291 ENOG4105NWN ApaG protein APS58_2292 ENOG4105DJV ribulose-phosphate 3-epimerase APS58_2294 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) APS58_2318 ENOG4108JIR Flagellum-specific ATP synthase APS58_2321 ENOG4107Y59 type iii secretion APS58_2331 ENOG4105K44 type iii secretion APS58_2333 ENOG4105E4C Lytic transglycosylase catalytic APS58_2339 ENOG4105DDQ anthranilate synthase APS58_2340 ENOG410829K Lysine exporter protein (Lyse ygga) APS58_2341 ENOG4107QYG anthranilate phosphoribosyltransferase APS58_2343 ENOG4105DK0 Indole-3-glycerol phosphate synthase APS58_2344 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) APS58_2346 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) APS58_2352 ENOG4105CPI Metal Dependent Phosphohydrolase APS58_2353 ENOG4105CB5 ATP-dependent DNA helicase recG APS58_2354 ENOG4105C5Q Transcriptional regulator APS58_2357 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) APS58_2362 ENOG4105II7 pyrroline-5-carboxylate reductase APS58_2363 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) APS58_2364 ENOG4105E98 transcriptional regulator DeoR family APS58_2365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) APS58_2366 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) APS58_2368 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component APS58_2372 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) APS58_2373 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) APS58_2374 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits APS58_2375 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) APS58_2376 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) APS58_2377 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) APS58_2378 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) APS58_2379 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) APS58_2380 ENOG4105VPB 50S ribosomal protein L30 APS58_2381 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) APS58_2382 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) APS58_2383 ENOG41067V7 50S ribosomal protein L36 APS58_2384 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits APS58_2385 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) APS58_2386 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) APS58_2387 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) APS58_2388 ENOG4108ZT0 50S ribosomal protein l17 APS58_2390 ENOG4105R8A Heat shock protein APS58_2391 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) APS58_2392 ENOG41082RQ UPF0102 protein APS58_2393 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) APS58_2394 ENOG4105W4M Transport-associated protein APS58_2395 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase APS58_2396 ENOG4105CZX twitching motility protein APS58_2397 ENOG4105IJJ transcriptional regulator, crp fnr family APS58_2398 ENOG4105CZX twitching motility protein APS58_2399 ENOG4105DFA alanine racemase domain protein APS58_2402 ENOG4106BRA Membrane APS58_2406 ENOG4105CQB FAD linked oxidase domain protein APS58_2410 ENOG4105BZU Histidine kinase APS58_2414 ENOG4105BZU Histidine kinase APS58_2415 ENOG4105WH1 Two component transcriptional regulator luxr family APS58_2418 ENOG4107ZSV Receptor APS58_2421 ENOG4105DQQ Major facilitator superfamily MFS_1 APS58_2422 ENOG4105CRU nitrate reductase, alpha subunit APS58_2423 ENOG4108IUE nitrate reductase beta subunit APS58_2424 ENOG4105R3A Nitrate reductase APS58_2425 ENOG4105D0D Nitrate reductase 2, gamma subunit APS58_2426 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) APS58_2431 ENOG4105NSG hemerythrin hhe cation binding domain protein APS58_2440 ENOG4105JN3 extra-cytoplasmic solute receptor family protein APS58_2443 ENOG4108UT2 hemolysin iii APS58_2447 ENOG4105CS6 Rhs element vgr protein APS58_2454 ENOG4105CG6 trap dicarboxylate transporter dctm subunit APS58_2455 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter APS58_2457 ENOG4105C01 Dihydroxy-acid dehydratase APS58_2458 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit APS58_2460 ENOG4105EQ1 Transcriptional regulator APS58_2462 ENOG4105CHJ isochorismatase hydrolase APS58_2470 ENOG4108J2R molybdopterin oxidoreductase APS58_2473 ENOG4105CH2 amidohydrolase APS58_2475 ENOG4105C8Q Methyl-accepting chemotaxis APS58_2478 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) APS58_2480 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase APS58_2484 ENOG4105DZS Phenylacetate-CoA ligase APS58_2485 ENOG4108IV0 ABC, transporter APS58_2487 ENOG4105CF8 branched-chain amino acid ABC transporter, permease APS58_2488 ENOG4105C32 Amino acid ABC transporter (Permease) APS58_2489 ENOG4105C0Z ABC transporter APS58_2493 ENOG4108M3P Membrane APS58_2494 ENOG4105I08 Pseudouridine synthase APS58_2496 ENOG41061H0 Monooxygenase APS58_2500 ENOG4105CYM Glutathione S-transferase APS58_2501 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) APS58_2503 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) APS58_2504 ENOG4105F32 YngK protein APS58_2507 ENOG4105DR4 Methyltransferase APS58_2508 ENOG4105BZU Histidine kinase APS58_2509 ENOG4105CKI cobalamin synthesis protein APS58_2510 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters APS58_2512 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) APS58_2513 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) APS58_2514 ENOG4108V6E Cell division protein mraZ APS58_2515 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) APS58_2517 ENOG4105CJN penicillin-binding protein APS58_2518 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) APS58_2519 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) APS58_2520 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) APS58_2521 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) APS58_2522 ENOG4105CNI cell division protein FtsW APS58_2523 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) APS58_2524 ENOG4105DFU Cell wall formation (By similarity) APS58_2525 ENOG4105CPF Cell wall formation (By similarity) APS58_2526 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) APS58_2527 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) APS58_2528 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) APS58_2529 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) APS58_2531 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) APS58_2532 ENOG4105C8Q Methyl-accepting chemotaxis APS58_2533 ENOG4105C8Q Methyl-accepting chemotaxis APS58_2535 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) APS58_2536 ENOG4105KNE Phosphatidate cytidylyltransferase APS58_2541 ENOG4108K2P TRANSCRIPTIONal APS58_2542 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase APS58_2543 ENOG4105E2X shikimate dehydrogenase APS58_2547 ENOG4105IPS esterase APS58_2548 ENOG4105CNI cell division protein FtsW APS58_2549 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) APS58_2550 ENOG4105D1U peptidase U62 modulator of DNA gyrase APS58_2552 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) APS58_2554 ENOG4105DFU Cell wall formation (By similarity) APS58_2556 ENOG4107QX9 Thiol disulfide interChange protein APS58_2557 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein APS58_2558 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase APS58_2559 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) APS58_2563 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) APS58_2564 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) APS58_2566 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family APS58_2567 ENOG4107TUY Histidine kinase APS58_2570 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY APS58_2572 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family APS58_2574 ENOG4107WP9 Histidine kinase APS58_2575 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) APS58_2580 ENOG4105FBW Monooxygenase APS58_2581 ENOG4108UZX fmn reductase APS58_2582 ENOG4107SM7 Transcriptional regulator APS58_2583 ENOG4105E39 Enoyl-CoA hydratase APS58_2585 ENOG4105T95 Thiol disulfide interChange protein APS58_2586 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family APS58_2587 ENOG4105QVC MOSC domain-containing protein APS58_2588 ENOG4105C3G gtp-binding protein APS58_2591 ENOG4108IJ8 ABC transporter APS58_2592 ENOG4105FR1 rard protein APS58_2593 ENOG4105W39 Membrane APS58_2594 ENOG4105BZU Histidine kinase APS58_2595 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) APS58_2596 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) APS58_2597 ENOG4105DC1 bifunctional purine biosynthesis protein purh APS58_2600 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase APS58_2601 ENOG4105DWF phosphomethylpyrimidine kinase APS58_2603 ENOG4108UNF response regulator APS58_2604 ENOG4105M3Z response regulator APS58_2605 ENOG4108V3W Chemotaxis protein, CheW APS58_2606 ENOG4105C8Q Methyl-accepting chemotaxis APS58_2607 ENOG4105CBS Chea signal transduction histidine kinase APS58_2609 ENOG4108UJU UPF0301 protein APS58_2610 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) APS58_2611 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) APS58_2612 ENOG4105CXT aspartate transcarbamylase APS58_2613 ENOG4105CD3 dihydroorotase APS58_2616 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) APS58_2617 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component APS58_2619 ENOG4107QHF type ii secretion system protein e APS58_2620 ENOG4105GVR general secretion pathway protein D APS58_2627 ENOG4105WMT general secretion pathway protein h APS58_2628 ENOG4108VAU general secretion pathway protein G APS58_2631 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) APS58_2632 ENOG4105C7B Threonine dehydratase APS58_2633 ENOG4108UKZ OsmC family APS58_2634 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) APS58_2635 ENOG4108Z9W Outer membrane porin APS58_2637 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component APS58_2638 ENOG4105CH2 amidohydrolase APS58_2639 ENOG4105DEF Extracellular solute-binding protein, family 5 APS58_2640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component APS58_2641 ENOG4105C3U ABC transporter APS58_2642 ENOG4108JQ7 (ABC) transporter APS58_2643 ENOG4105C8Q Methyl-accepting chemotaxis APS58_2645 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase APS58_2646 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) APS58_2647 ENOG4107QP8 phosphohexose isomerase APS58_2648 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) APS58_2649 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) APS58_2653 ENOG4107QQG Dehydrogenase APS58_2654 ENOG4107R5Z Oxidoreductase domain protein APS58_2655 ENOG4105J5G Transferase hexapeptide repeat containing protein APS58_2656 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase APS58_2657 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase APS58_2658 ENOG4105MFV ABC-2 type transporter APS58_2659 ENOG4105EY8 ABC transporter APS58_2660 ENOG4105DVA methyltransferase APS58_2661 ENOG4105CPK Glycosyl transferase (Group 1 APS58_2663 ENOG4105CAQ asparagine synthetase APS58_2664 ENOG4107EF8 Glycosyl transferase (Group 1 APS58_2665 ENOG4105CAQ asparagine synthetase APS58_2669 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) APS58_2671 ENOG4108R86 Transcriptional regulator APS58_2672 ENOG4105BZ8 glutamate synthase APS58_2673 ENOG4107SJI Dehydrogenase APS58_2674 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease APS58_2675 ENOG4105CD3 dihydroorotase APS58_2676 ENOG4105CE7 Amidase, hydantoinase carbamoylase family APS58_2682 ENOG4107RH7 Nicotinate phosphoribosyltransferase APS58_2685 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP APS58_2687 ENOG4105D1S lipid A biosynthesis APS58_2689 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) APS58_2690 ENOG4106RE7 Cytochrome APS58_2691 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) APS58_2692 ENOG4105CRE cytochrome C APS58_2693 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) APS58_2694 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) APS58_2698 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) APS58_2700 ENOG4105XQ6 frataxin-like protein APS58_2701 ENOG4108JQC penicillin-binding protein 1A APS58_2706 ENOG4105E4G Type IV pilus APS58_2708 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) APS58_2709 ENOG4105D49 3-dehydroquinate synthase APS58_2710 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein APS58_2716 ENOG4106TNF Periplasmic binding protein APS58_2717 ENOG4105E5Q amino acid AbC transporter APS58_2718 ENOG4105CDA abc transporter atp-binding protein APS58_2719 ENOG4105DHJ ABC, transporter APS58_2720 ENOG4105CY3 ABC transporter, permease APS58_2721 ENOG4107PE3 Mammalian cell entry related domain protein APS58_2722 ENOG410903C (LipO)protein APS58_2726 ENOG4105DA5 (ABC) transporter APS58_2727 ENOG4105E3A (ABC) transporter APS58_2728 ENOG4105VFK BolA family APS58_2730 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) APS58_2731 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) APS58_2732 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) APS58_2740 ENOG4105CIH Imidazole acetol-phosphate transaminase APS58_2741 ENOG4105ECC imidazole-glycerol-phosphate dehydratase APS58_2742 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) APS58_2743 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase APS58_2747 ENOG4108I69 Glycosyl transferases group 1 APS58_2753 ENOG4105CMR udp-glucose 4-epimerase APS58_2754 ENOG4105CK2 sodium dicarboxylate symporter APS58_2756 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) APS58_2757 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase APS58_2758 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase APS58_2761 ENOG4107YU2 histidine triad (hIT) protein APS58_2762 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) APS58_2763 ENOG4107Z6S Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) APS58_2764 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) APS58_2768 ENOG4105C0H protease APS58_2769 ENOG4105CSH Transporter APS58_2770 ENOG4107QNR UPF0135 protein APS58_2774 ENOG4105C7R Atpase associated with various cellular activities aaa_3 APS58_2775 ENOG4105C0H protease APS58_2776 ENOG4105EYA deoxyribonuclease APS58_2778 ENOG4105I7M spermidine synthase APS58_2779 ENOG4107QHF type ii secretion system protein e APS58_2787 ENOG4108JU3 Alkyl hydroperoxide reductase APS58_2789 ENOG4105CHR reductase APS58_2790 ENOG4105C8Q Methyl-accepting chemotaxis APS58_2791 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) APS58_2795 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) APS58_2798 ENOG4107EXU Short-chain dehydrogenase reductase Sdr APS58_2800 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component APS58_2801 ENOG4105D7T ABC transporter APS58_2804 ENOG4105C6K Malic enzyme APS58_2805 ENOG4105C2W permease APS58_2808 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease APS58_2809 ENOG4107YCY Transcriptional regulator APS58_2810 ENOG4105C8Q Methyl-accepting chemotaxis APS58_2811 ENOG4105CK2 sodium dicarboxylate symporter APS58_2817 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) APS58_2820 ENOG4107YCY Transcriptional regulator APS58_2822 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) APS58_2823 ENOG4105VT2 5-hydroxyisourate hydrolase APS58_2827 ENOG4105BZU Histidine kinase APS58_2830 ENOG4105KME endoribonuclease L-psp APS58_2832 ENOG4108Z9W Outer membrane porin APS58_2834 ENOG4105BZU Histidine kinase APS58_2837 ENOG4105C7W Xanthine dehydrogenase APS58_2842 ENOG4105C2J ABC transporter APS58_2843 ENOG4105UIB (ABC) transporter APS58_2849 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) APS58_2852 ENOG4105C5I Dehydrogenase APS58_2855 ENOG4105DHP deoxycytidine triphosphate deaminase APS58_2858 ENOG4105CGZ zinc metallopeptidase APS58_2859 ENOG4105C1J atp-dependent rna helicase APS58_2860 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) APS58_2861 ENOG4107M1U Histone family protein nucleoid-structuring protein H-NS APS58_2862 ENOG4107QM5 aconitate hydratase APS58_2863 ENOG4105BZU Histidine kinase APS58_2866 ENOG4105BZU Histidine kinase APS58_2868 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) APS58_2870 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) APS58_2871 ENOG4108YXU transcriptional regulator AsnC family APS58_2872 ENOG4105PI0 Ferredoxin APS58_2874 ENOG4105CE1 Ferrous iron transport protein b APS58_2877 ENOG4105DBV ornithine carbamoyltransferase APS58_2878 ENOG4105C8Y Acetylornithine aminotransferase APS58_2880 ENOG4105DWT malate dehydrogenase (quinone) APS58_2881 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) APS58_2882 ENOG4105CJR Integral membrane protein (MviN APS58_2883 ENOG41063JG Transcriptional regulator APS58_2884 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) APS58_2886 ENOG4105D1Q UPF0246 protein APS58_2887 ENOG4105C03 ribonuclease APS58_2889 ENOG4105EI2 Pseudouridine synthase APS58_2892 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) APS58_2893 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) APS58_2894 ENOG4108UHJ MAF-like protein APS58_2895 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein APS58_2896 ENOG4105VGS 50s ribosomal protein l32 APS58_2897 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) APS58_2898 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) APS58_2899 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase APS58_2900 ENOG4105CHR reductase APS58_2901 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) APS58_2902 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) APS58_2904 ENOG4105EMN RNA polymerase sigma factor APS58_2907 ENOG4105C0H protease APS58_2908 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) APS58_2909 ENOG4105C3F Signal peptidase i APS58_2911 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) APS58_2912 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) APS58_2913 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) APS58_2914 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) APS58_2915 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) APS58_2916 ENOG4108NST exported protein APS58_2919 ENOG4105CRK lysyL-tRNA synthetase APS58_2927 ENOG4108VIA integral membrane protein APS58_2928 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) APS58_2929 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) APS58_2930 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) APS58_2931 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase APS58_2932 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) APS58_2934 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) APS58_2937 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) APS58_2938 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) APS58_2940 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) APS58_2942 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) APS58_2943 ENOG4105CFG Acts as a chaperone (By similarity) APS58_2944 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ APS58_2945 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) APS58_2947 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) APS58_2948 ENOG4105K9Q Binds to the 23S rRNA (By similarity) APS58_2949 ENOG4105CDU Replicative dna helicase APS58_2951 ENOG4108IAB Phoh family APS58_2952 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen APS58_2967 ENOG4105CHM Aminotransferase APS58_2968 ENOG4105D6E homoserine dehydrogenase APS58_2970 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b APS58_2971 ENOG4105CVM Molybdenum cofactor synthesis domain protein APS58_2972 ENOG4105M00 molybdopterin converting factor, subunit 1 APS58_2973 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) APS58_2978 ENOG4108ZAF Molybdopterin APS58_2979 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit APS58_2981 ENOG4107RGH Aldehyde dehydrogenase APS58_2983 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) APS58_2985 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) APS58_2986 ENOG4107RZC phospholipase d APS58_2988 ENOG4105CHM Aminotransferase APS58_2989 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) APS58_2990 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) APS58_2992 ENOG4105CP7 Triose-phosphate isomerase APS58_2993 ENOG4107EJC Preprotein translocase subunit SecG APS58_2995 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain APS58_2996 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) APS58_2997 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain APS58_2998 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) APS58_2999 ENOG4105GKE subunit e APS58_3000 ENOG4107QIZ NADH dehydrogenase APS58_3001 ENOG4108IEH NADH dehydrogenase subunit g APS58_3002 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) APS58_3003 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) APS58_3004 ENOG4105DF2 NADH dehydrogenase subunit j APS58_3005 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) APS58_3007 ENOG4105C8S subunit m APS58_3008 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) APS58_3011 ENOG4105BZ1 (ABC) transporter APS58_3012 ENOG4105C0Z ABC transporter APS58_3013 ENOG4108IV0 ABC, transporter APS58_3016 ENOG4105C32 Amino acid ABC transporter (Permease) APS58_3020 ENOG4107TVC Glycosyl transferase, family 2 APS58_3024 ENOG4105VN1 Heat shock protein APS58_3025 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) APS58_3026 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) APS58_3027 ENOG4105ECR NmrA family APS58_3028 ENOG4105KVH Transcriptional regulator APS58_3029 ENOG4105E5G Alpha beta hydrolase fold APS58_3030 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase APS58_3032 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) APS58_3033 ENOG4105DQR SNARE associated Golgi APS58_3034 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) APS58_3037 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase APS58_3038 ENOG4105K8N protein family UPF0079, ATPase APS58_3039 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) APS58_3041 ENOG4105DUM transcriptional regulator, lysR family APS58_3045 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) APS58_3048 ENOG4105D58 Diguanylate phosphodiesterase APS58_3049 ENOG4105D58 Diguanylate phosphodiesterase APS58_3050 ENOG4105ED9 Protein of unknown function (DUF455) APS58_3051 ENOG4108Z0R Transferase APS58_3052 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) APS58_3054 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) APS58_3055 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) APS58_3060 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) APS58_3061 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase APS58_3062 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) APS58_3064 ENOG4108YZY peptidylprolyl cis-trans isomerase APS58_3065 ENOG4105EZE Cupin 4 family protein APS58_3068 ENOG4105Q2H domain protein APS58_3069 ENOG4105GJM (LipO)protein APS58_3070 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) APS58_3074 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) APS58_3075 ENOG4105E4C Lytic transglycosylase catalytic APS58_3076 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) APS58_3077 ENOG4105C8Q Methyl-accepting chemotaxis APS58_3078 ENOG4105C8Q Methyl-accepting chemotaxis APS58_3079 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) APS58_3087 ENOG4108EC8 DNA internalization-related competence protein ComEC APS58_3092 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) APS58_3094 ENOG4105VYA Uncharacterized conserved protein (DUF2132) APS58_3097 ENOG4105ENT Efflux transporter rnd family, mfp subunit APS58_3102 ENOG4105E0K tonB-dependent siderophore receptor APS58_3110 ENOG4108UQY Iron-storage protein APS58_3112 ENOG4108JU3 Alkyl hydroperoxide reductase APS58_3113 ENOG4105HSS phospholipase C APS58_3117 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) APS58_3118 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) APS58_3120 ENOG4107QN1 sodium solute APS58_3123 ENOG4108V1T peptidylprolyl cis-trans isomerase APS58_3125 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F APS58_3128 ENOG4107YNJ LysR family Transcriptional regulator APS58_3129 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) APS58_3131 ENOG4105CHR reductase APS58_3132 ENOG4105CMJ mandelate racemase muconate lactonizing APS58_3140 ENOG4105C8Q Methyl-accepting chemotaxis APS58_3141 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) APS58_3142 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) APS58_3143 ENOG4105BZU Histidine kinase APS58_3144 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit APS58_3145 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) APS58_3146 ENOG4105DGI Alkaline phosphatase APS58_3147 ENOG4105BZU Histidine kinase APS58_3149 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) APS58_3150 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) APS58_3152 ENOG4105C34 Pseudouridine synthase APS58_3153 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) APS58_3154 ENOG4105FE9 pseudouridine synthase APS58_3155 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) APS58_3156 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs APS58_3157 ENOG4108PPB Seems to be required for the assembly of the photosystem I complex (By similarity) APS58_3159 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) APS58_3160 ENOG4105CUT histidyl-tRNA synthetase APS58_3163 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) APS58_3164 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) APS58_3165 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) APS58_3166 ENOG4107QJR hflk protein APS58_3167 ENOG4105EPW hflc protein APS58_3168 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) APS58_3169 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis APS58_3170 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) APS58_3176 ENOG4105I08 Pseudouridine synthase APS58_3182 ENOG4105C5F glutamine synthetase APS58_3184 ENOG4105CUX Signal transduction histidine kinase APS58_3185 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family APS58_3187 ENOG4105CGK Exodeoxyribonuclease III APS58_3190 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) APS58_3192 ENOG4105CQB FAD linked oxidase domain protein APS58_3194 ENOG4107S2Z UPF0761 membrane protein APS58_3195 ENOG4107S11 squalene-associated FAD-dependent desaturase APS58_3196 ENOG4105FE1 phytoene synthase APS58_3200 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) APS58_3201 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) APS58_3202 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) APS58_3203 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation APS58_3205 ENOG4105BZS acriflavin resistance protein APS58_3213 ENOG4108ZF3 Phosphatase APS58_3216 ENOG4108ZG0 Ompa motb domain protein APS58_3226 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit APS58_3229 ENOG4108VKG metal-dependent hydrolase APS58_3230 ENOG4105C7W Xanthine dehydrogenase APS58_3231 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding APS58_3232 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit APS58_3233 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) APS58_3235 ENOG4105BZU Histidine kinase APS58_3238 ENOG4105E3W Two component transcriptional regulator (Winged helix family APS58_3239 ENOG4105EB3 Histidine kinase APS58_3240 ENOG4105GIJ Glycine betaine APS58_3241 ENOG4108HQS Glycine betaine APS58_3242 ENOG4108IJ7 Glycine betaine APS58_3243 ENOG4108TEB UPF0114 protein APS58_3244 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) APS58_3248 ENOG4105W2Z cytochrome C, class I APS58_3250 ENOG4105C01 Dihydroxy-acid dehydratase APS58_3251 ENOG4108UWD Iron-storage protein APS58_3253 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) APS58_3254 ENOG4105DRR Transcriptional regulator, GntR family APS58_3258 ENOG4105CEY Amp-dependent synthetase and ligase APS58_3260 ENOG4107YZX Universal stress protein APS58_3262 ENOG4105C59 p-type ATPase APS58_3264 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i APS58_3271 ENOG4105DS0 Transcriptional regulator, Crp Fnr family APS58_3272 ENOG4105D4P Coproporphyrinogen iii oxidase APS58_3274 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase APS58_3275 ENOG4105BZU Histidine kinase APS58_3278 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) APS58_3279 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) APS58_3280 ENOG4108YZT Adenosylcobinamide kinase APS58_3282 ENOG4105EHG Permease protein APS58_3283 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) APS58_3284 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase APS58_3285 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase APS58_3286 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) APS58_3289 ENOG4106N2S APS58_3292 ENOG4105H9W Short-chain dehydrogenase reductase Sdr APS58_3294 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) APS58_3295 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) APS58_3300 ENOG4105CSH Transporter APS58_3302 ENOG4105XYF acetyltransferase APS58_3304 ENOG4105CSM endonuclease III APS58_3305 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family APS58_3306 ENOG41069P5 Protein slyX homolog APS58_3309 ENOG4105C1J atp-dependent rna helicase APS58_3313 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) APS58_3315 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) APS58_3317 ENOG4105D01 (LipO)protein APS58_3318 ENOG4105EAC phosphoserine phosphatase APS58_3322 ENOG4108JA2 transcriptioN-repair coupling factor APS58_3323 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) APS58_3324 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) APS58_3325 ENOG4105E0F Histidine kinase APS58_3326 ENOG4105DPZ Two component transcriptional regulator (Winged helix family APS58_3328 ENOG4105DTD Dehydrogenase APS58_3330 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) APS58_3338 ENOG4108Z0Z intracellular protease Pfpi family APS58_3340 ENOG4108NVM synthesis repressor PhaR APS58_3341 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) APS58_3345 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) APS58_3348 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F APS58_3349 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase APS58_3353 ENOG4105D44 asparaginase APS58_3354 ENOG4108JQ6 ABC transporter APS58_3356 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component APS58_3357 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component APS58_3361 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) APS58_3363 ENOG4105K70 DNA-binding protein APS58_3369 ENOG4108R7K Metal Dependent Phosphohydrolase APS58_3394 ENOG4105CAR Terminase, large subunit APS58_3401 ENOG4108TFU terminase (Small subunit) APS58_3427 ENOG4105X5T APS58_3442 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) APS58_3448 ENOG4105CHR reductase APS58_3452 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) APS58_3454 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase APS58_3456 ENOG4105C26 Dehydrogenase APS58_3461 ENOG4105D25 secreted protein APS58_3462 ENOG4105C26 Dehydrogenase APS58_3463 ENOG4108K3Z AraC family transcriptional regulator APS58_3466 ENOG4108JPW Aminotransferase APS58_3472 ENOG4105CKD glutathione-regulated potassium-efflux system protein APS58_3474 ENOG4105C1J atp-dependent rna helicase APS58_3475 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) APS58_3476 ENOG4105C5H ABC transporter APS58_3479 ENOG4105KXX peptidase s58 dmpa APS58_3482 ENOG4105EXG Transcriptional regulator APS58_3485 ENOG4107R16 Multicopper oxidase APS58_3491 ENOG4105W1Y Transcriptional regulator APS58_3497 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) APS58_3498 ENOG4105MWK D-amino acid dehydrogenase, small subunit APS58_3499 ENOG4105CE9 30S ribosomal protein S2 APS58_3500 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) APS58_3501 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) APS58_3502 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) APS58_3504 ENOG4105KNE Phosphatidate cytidylyltransferase APS58_3505 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) APS58_3506 ENOG4105DZP Membrane-associated zinc metalloprotease APS58_3507 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane APS58_3509 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) APS58_3510 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) APS58_3511 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) APS58_3512 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) APS58_3513 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) APS58_3515 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F APS58_3517 ENOG4105CSU acyl-Coa dehydrogenase APS58_3518 ENOG4107RSM transcriptional regulator APS58_3520 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 APS58_3521 ENOG4105CD8 aminopeptidase N APS58_3523 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) APS58_3524 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) APS58_3525 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) APS58_3527 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) APS58_3528 ENOG4105CPC Aldo Keto reductase APS58_3529 ENOG4108Z66 YbaK ebsC protein APS58_3530 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) APS58_3532 ENOG4108WIW Aspartyl protease APS58_3533 ENOG4108VPT UPF0234 protein APS58_3535 ENOG4105CDH Citrulline--aspartate ligase APS58_3536 ENOG4105NBK UPF0345 protein APS58_3538 ENOG4105KUZ arsenate reductase APS58_3539 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase APS58_3541 ENOG4105E96 Colicin v production protein APS58_3542 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase APS58_3543 ENOG4105C28 cystathionine APS58_3544 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) APS58_3552 ENOG4105C2C drug resistance transporter, Bcr CflA APS58_3553 ENOG4105C0R drug resistance transporter emrb qaca subfamily APS58_3559 ENOG4105BZM domain protein APS58_3562 ENOG4108JB8 alcohol dehydrogenase APS58_3563 ENOG4105IKQ hydratase APS58_3566 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) APS58_3567 ENOG4105HHA aminodeoxychorismate lyase APS58_3568 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) APS58_3571 ENOG4105F8V Hydrolase, tatD family APS58_3573 ENOG4105BZ1 (ABC) transporter APS58_3574 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) APS58_3575 ENOG4105KCK Peptidoglycan-associated lipoprotein APS58_3577 ENOG4105CUZ uba thif-type nad fad binding protein APS58_3581 ENOG4105F84 Ornithine cyclodeaminase APS58_3597 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding APS58_3599 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) APS58_3600 ENOG4105CHV Transcription elongation factor NusA APS58_3601 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) APS58_3602 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) APS58_3603 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) APS58_3605 ENOG4105EE5 Membrane protein terC APS58_3606 ENOG4105E39 Enoyl-CoA hydratase APS58_3610 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) APS58_3611 ENOG4108Z1B Cyclase dehydrase APS58_3612 ENOG4105VDB UPF0125 protein APS58_3614 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) APS58_3617 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) APS58_3618 ENOG4105DFP Integrase APS58_3627 ENOG4105CVR type I restriction-modification system APS58_3628 ENOG4107XZC Restriction modification system DNA (Specificity APS58_3629 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) APS58_3634 ENOG4105EQ2 LysR family Transcriptional regulator APS58_3636 ENOG4105CHR reductase APS58_3639 ENOG4105CS6 Rhs element vgr protein APS58_3641 ENOG4105CNA YD repeat protein APS58_3649 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) APS58_3650 ENOG4105CAY ferredoxin--nadp reductase APS58_3653 ENOG4105VEQ Cold shock protein APS58_3654 ENOG4107VIJ nudix hydrolase APS58_3659 ENOG4108K3A Glutathione S-transferase APS58_3661 ENOG4108ESX Receptor APS58_3662 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) APS58_3664 ENOG4105EHG Permease protein APS58_3666 ENOG4105C26 Dehydrogenase APS58_3667 ENOG4105EW9 transcriptional regulator AsnC family APS58_3669 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) APS58_3671 ENOG4108MN8 Membrane APS58_3672 ENOG4108ZJF Glcg protein APS58_3674 ENOG4105SG9 biopolymer transport protein, ExbD APS58_3678 ENOG4108WFY phasin family APS58_3680 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) APS58_3681 ENOG4107RH7 Nicotinate phosphoribosyltransferase APS58_3682 ENOG4105C5I Dehydrogenase APS58_3683 ENOG4107QSV RmuC domain protein APS58_3688 ENOG4107Z6W Protein CrcB homolog APS58_3689 ENOG4105CG6 trap dicarboxylate transporter dctm subunit APS58_3695 ENOG4105W4C monovalent cation H antiporter subunit F APS58_3697 ENOG4107R4Z monovalent cation h antiporter subunit d APS58_3698 ENOG4108ZE9 Monovalent cation H antiporter subunit C APS58_3699 ENOG4105D65 subunit l APS58_3700 ENOG4105CFV Tetratricopeptide repeat protein APS58_3702 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) APS58_3703 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) APS58_3704 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase APS58_3706 ENOG4105CQC Prephenate dehydratase APS58_3707 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) APS58_3708 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) APS58_3709 ENOG4105UYK outer membrane protein a APS58_3710 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) APS58_3711 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) APS58_3715 ENOG4105ETX regulatoR APS58_3731 ENOG4105CXN decarboxylase APS58_3733 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH APS58_3734 ENOG4105E43 Extracellular solute-binding protein, family 5 APS58_3735 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component APS58_3736 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component APS58_3737 ENOG4108JQ5 ABC transporter APS58_3738 ENOG4105BZU Histidine kinase APS58_3739 ENOG4105IPI Membrane APS58_3740 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 APS58_3741 ENOG4105C7S Dehydrogenase APS58_3742 ENOG4107QN2 dihydrolipoyl dehydrogenase APS58_3743 ENOG4105D6Z AFG1 family ATPase APS58_3746 ENOG4105DVT helicase APS58_3748 ENOG4105C0B DNA polymerase III (alpha subunit) APS58_3749 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) APS58_3750 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit APS58_3751 ENOG4105CVE Lytic murein transglycosylase APS58_3752 ENOG4105CJB Exodeoxyribonuclease I APS58_3753 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) APS58_3754 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family APS58_3758 ENOG4105C26 Dehydrogenase APS58_3759 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) APS58_3766 ENOG4105DZC cytosine deaminase APS58_3768 ENOG4108YYQ gCN5-related N-acetyltransferase APS58_3771 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) APS58_3774 ENOG4105CYM Glutathione S-transferase APS58_3777 ENOG4105KHC sulfurtransferase APS58_3779 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase APS58_3780 ENOG4105CQB FAD linked oxidase domain protein APS58_3784 ENOG4105D7A ATP-binding protein APS58_3785 ENOG4105CDY transcriptional regulatory protein APS58_3786 ENOG4105C12 Phosphoribosylglycinamide synthetase APS58_3787 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) APS58_3788 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) APS58_3789 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) APS58_3791 ENOG4108Z03 MAF-like protein APS58_3792 ENOG4105C03 ribonuclease APS58_3801 ENOG4105CPB ATP-dependent endonuclease of the OLD family APS58_3803 ENOG4105BZU Histidine kinase APS58_3804 ENOG4107R6F Alpha Beta Hydrolase Fold protein APS58_3807 ENOG4105DTD Dehydrogenase APS58_3809 ENOG4108UKI Enoyl-CoA hydratase APS58_3810 ENOG4105C1G acyl-Coa dehydrogenase APS58_3812 ENOG4105CAD extracellular ligand-binding receptor APS58_3813 ENOG4105C32 Amino acid ABC transporter (Permease) APS58_3815 ENOG4105C0Z ABC transporter APS58_3816 ENOG4108IV0 ABC, transporter APS58_3819 ENOG4105CHM Aminotransferase APS58_3820 ENOG4107R11 Transcriptional regulator APS58_3824 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) APS58_3832 ENOG41081QV Universal stress protein APS58_3834 ENOG4105DFH Transport of potassium into the cell (By similarity) APS58_3836 ENOG410904N short-chain dehydrogenase reductase APS58_3837 ENOG4105D3G Pseudouridine synthase APS58_3839 ENOG4108V1T peptidylprolyl cis-trans isomerase APS58_3840 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor APS58_3842 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) APS58_3844 ENOG4105EW9 transcriptional regulator AsnC family APS58_3846 ENOG4105C7J ABC transporter, permease APS58_3849 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase APS58_3850 ENOG4108R85 Short chain dehydrogenase APS58_3851 ENOG4105CH6 catalase APS58_3858 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) APS58_3860 ENOG4105CEP NADH dehydrogenase APS58_3868 ENOG4105EMY transcriptional regulator APS58_3871 ENOG4108YZA Nitrogen regulatory protein pii APS58_3872 ENOG4108URH decarboxylase APS58_3873 ENOG41080IJ Diacylglycerol kinase APS58_3877 ENOG4105JVQ RNA Polymerase APS58_3879 ENOG4105C7K acetolactate synthase APS58_3880 ENOG4108ZP8 Acetolactate synthase small subunit APS58_3881 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase APS58_3882 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase APS58_3883 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) APS58_3884 ENOG41061WM D-Alanyl-D-Alanine APS58_3885 ENOG41069M3 Transcriptional regulator APS58_3886 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate APS58_3887 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) APS58_3890 ENOG4105WD1 Membrane APS58_3891 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) APS58_3892 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) APS58_3893 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) APS58_3894 ENOG4108ETH Formylglycinamide ribotide synthetase APS58_3897 ENOG4105BZU Histidine kinase APS58_3898 ENOG4105CKW Inner membrane protein yedI APS58_3900 ENOG4105BZU Histidine kinase APS58_3902 ENOG41067HS methyltransferase APS58_3903 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process APS58_3905 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein APS58_3908 ENOG4105CFP Peptidase U32 APS58_3912 ENOG4108Z6B deaminase APS58_3913 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A APS58_3916 ENOG4105C1G acyl-Coa dehydrogenase APS58_3919 ENOG4108UKI Enoyl-CoA hydratase APS58_3920 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase APS58_3922 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) APS58_3923 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) APS58_3927 ENOG4105D9P serine threonine protein kinase APS58_3936 ENOG4105CAY ferredoxin--nadp reductase APS58_3937 ENOG4108Z4U Ferredoxin APS58_3938 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) APS58_3939 ENOG4105C11 sulfate adenylyltransferase), subunit 2 APS58_3942 ENOG4107TSN permease APS58_3945 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) APS58_3946 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) APS58_3947 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein APS58_3949 ENOG4105GVF (ABC) transporter APS58_3951 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) APS58_3953 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component APS58_3954 ENOG4105E2Y ABC, transporter APS58_3956 ENOG4107R11 Transcriptional regulator APS58_3959 ENOG4105W2Z cytochrome C, class I APS58_3962 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) APS58_3963 ENOG4105BZU Histidine kinase APS58_3964 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) APS58_3965 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) APS58_3966 ENOG4105CVN desaturase APS58_3967 ENOG4105CWB LysR family transcriptional Regulator APS58_3968 ENOG4105C2I pirin domain protein APS58_3970 ENOG4105EUB pirin domain protein APS58_3971 ENOG4105C72 UPF0176 protein APS58_3972 ENOG4107R21 site-determining protein APS58_3973 ENOG4105BZU Histidine kinase APS58_3976 ENOG4105C28 cystathionine APS58_3978 ENOG4108UJV acyl-CoA thioesterase i APS58_3979 ENOG4108I0Y (ABC) transporter APS58_3980 ENOG4105C2N RNA methyltransferase TrmH family group 3 APS58_3981 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) APS58_3982 ENOG4105CPC Aldo Keto reductase APS58_3985 ENOG4105DHQ Histidine kinase APS58_3993 ENOG4106BE1 Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers (By similarity) APS58_3997 ENOG4105BZU Histidine kinase APS58_3998 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) APS58_3999 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant APS58_4002 ENOG4108IJ8 ABC transporter APS58_4003 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase APS58_4005 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) APS58_4006 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) APS58_4007 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division APS58_4012 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) APS58_4013 ENOG41061TZ Short-chain dehydrogenase reductase Sdr APS58_4015 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) APS58_4019 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) APS58_4021 ENOG4105BZU Histidine kinase APS58_4024 ENOG4105BZU Histidine kinase APS58_4025 ENOG4105BZU Histidine kinase APS58_4027 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase APS58_4028 ENOG4105FUA antagonist APS58_4029 ENOG4107MMM Anti-sigma-factor antagonist APS58_4031 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component APS58_4033 ENOG4105CZE histidine utilization repressor APS58_4034 ENOG4105C84 Histidine ammonia-lyase APS58_4035 ENOG4105CGP Urocanate hydratase APS58_4038 ENOG4105CI2 imidazolone-5-propionate hydrolase APS58_4041 ENOG4107AQZ Membrane APS58_4044 ENOG4105DJ4 phosphatidylserine decarboxylase APS58_4045 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) APS58_4049 ENOG4107TF3 peptidylprolyl cis-trans isomerase APS58_4051 ENOG4107835 probably involved in intracellular septation (By similarity) APS58_4052 ENOG4105E0X reductase APS58_4053 ENOG4105CNG UPF0061 protein APS58_4054 ENOG4105CEY Amp-dependent synthetase and ligase APS58_4056 ENOG4105C32 Amino acid ABC transporter (Permease) APS58_4058 ENOG4105C0Z ABC transporter APS58_4059 ENOG4108IV0 ABC, transporter APS58_4063 ENOG4106TD9 Diguanylate cyclase APS58_4064 ENOG4105BZU Histidine kinase APS58_4066 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase APS58_4067 ENOG4105CHU acetyl-coa acetyltransferase APS58_4068 ENOG4108VUY thioesterase Superfamily protein APS58_4069 ENOG4105CSU acyl-Coa dehydrogenase APS58_4071 ENOG4105CHR reductase APS58_4073 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein APS58_4080 ENOG4108Q5Y Membrane APS58_4081 ENOG4105F7P transcriptional regulator AsnC family APS58_4084 ENOG4108I9X Isocitrate lyase APS58_4085 ENOG4105C22 threonyL-tRNA synthetase APS58_4086 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) APS58_4087 ENOG4105VJV 50s ribosomal protein L35 APS58_4088 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) APS58_4089 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) APS58_4090 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) APS58_4091 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) APS58_4092 ENOG4108XDN Transcriptional regulator APS58_4097 ENOG4105BZ1 (ABC) transporter APS58_4098 ENOG4107R5R arsenical pump membrane protein APS58_4099 ENOG4105BZU Histidine kinase APS58_4100 ENOG4105KK4 UPF0060 membrane protein APS58_4102 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) APS58_4104 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) APS58_4106 ENOG4105EGS Mechanosensitive ion channel APS58_4107 ENOG4105BZJ Electron transfer flavoprotein APS58_4108 ENOG4105C10 Electron transfer flavoprotein APS58_4109 ENOG4105CSU acyl-Coa dehydrogenase APS58_4118 ENOG4105CH2 amidohydrolase APS58_4119 ENOG4108RYR transcriptional regulator AsnC family APS58_4120 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) APS58_4121 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase APS58_4125 ENOG4105CJP fad dependent oxidoreductase APS58_4128 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component APS58_4130 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) APS58_4132 ENOG4105DIJ Phosphoethanolamine transferase APS58_4133 ENOG4105C4W S-formylglutathione hydrolase APS58_4134 ENOG4107QPD alcohol dehydrogenase APS58_4136 ENOG41068WN APS58_4139 ENOG4105BZN citrate synthase APS58_4140 ENOG41060IS Flavinator of succinate dehydrogenase APS58_4141 ENOG4105E33 succinate dehydrogenase APS58_4145 ENOG4105FDP GntR family transcriptional regulator APS58_4146 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) APS58_4147 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) APS58_4151 ENOG4107QIJ Aconitate hydratase 2 APS58_4155 ENOG4105CFP Peptidase U32 APS58_4156 ENOG4108W5M transcriptional regulator APS58_4158 ENOG4108UYB regulatoR APS58_4159 ENOG4105DS4 PAS PAC sensor Signal transduction histidine kinase APS58_4161 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) APS58_4162 ENOG4105CCU oxidase (Subunit III) APS58_4163 ENOG4105BZ9 Cytochrome C oxidase, subunit I APS58_4164 ENOG4105E2S oxidase) subunit II APS58_4165 ENOG4105CSH Transporter APS58_4167 ENOG4105M8F Biopolymer transport protein exbD tolR APS58_4168 ENOG4105E02 MotA TolQ exbB proton channel APS58_4169 ENOG4107YD3 Thioesterase APS58_4170 ENOG4105CHM Aminotransferase APS58_4171 ENOG4107YIM Involved in the transcription termination process (By similarity) APS58_4172 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) APS58_4173 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) APS58_4177 ENOG4105BZU Histidine kinase APS58_4179 ENOG4105CK6 Two component transcriptional regulator (Winged helix family APS58_4180 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) APS58_4182 ENOG4105C8Q Methyl-accepting chemotaxis APS58_4184 ENOG4105ME7 Membrane APS58_4185 ENOG4105CXK mandelate racemase muconate lactonizing APS58_4186 ENOG4108RTU Aldolase APS58_4187 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 APS58_4190 ENOG41062B0 ABC transporter, permease APS58_4191 ENOG4107R9N ABC transporter APS58_4192 ENOG4105C2J ABC transporter APS58_4193 ENOG4107RNG ABC transporter APS58_4195 ENOG4105DFW ABC transporter APS58_4196 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator APS58_4200 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein APS58_4203 ENOG4105D9M gamma-glutamylcysteine synthetase APS58_4205 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) APS58_4207 ENOG4108NIW Leucine export protein LeuE APS58_4211 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) APS58_4212 ENOG4108Z9W Outer membrane porin APS58_4215 ENOG4105EQ0 Major Facilitator superfamily APS58_4217 ENOG4108Z4X TRANSCRIPTIONal APS58_4218 ENOG4108302 MgtC SapB transporter APS58_4219 ENOG4105DR9 pseudouridine synthase APS58_4226 ENOG4105C8Q Methyl-accepting chemotaxis APS58_4230 ENOG4108R99 pseudouridine synthase APS58_4232 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) APS58_4239 ENOG4108RZE Tetr family transcriptional regulator APS58_4243 ENOG4105CX6 glutaminyL-tRNA synthetase APS58_4245 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) APS58_4247 ENOG4108YZN class I peptide chain release factor APS58_4248 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b APS58_4252 ENOG4108YXU transcriptional regulator AsnC family APS58_4253 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) APS58_4256 ENOG4105JN3 extra-cytoplasmic solute receptor family protein APS58_4258 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) APS58_4259 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) APS58_4264 ENOG4105C8N cysteinyl-tRNA synthetase APS58_4267 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) APS58_4268 ENOG4105CFH Aspartokinase APS58_4275 ENOG4108TFU terminase (Small subunit) APS58_4278 ENOG4105CS6 Rhs element vgr protein APS58_4280 ENOG4105CNA YD repeat protein APS58_4289 ENOG4105K4H Nlp p60 protein APS58_4290 ENOG4105D8V Glucose sorbosone dehydrogenase APS58_4292 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) APS58_4293 ENOG4105BZU Histidine kinase APS58_4297 ENOG4107QKV phosphomannomutase APS58_4299 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase APS58_4300 ENOG4105CD5 CoA-binding domain protein APS58_4301 ENOG4105DFG type I secretion outer membrane protein APS58_4303 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) APS58_4304 ENOG4105YA8 Transcriptional regulator APS58_4305 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) APS58_4307 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) APS58_4312 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) APS58_4313 ENOG4105MWK D-amino acid dehydrogenase, small subunit APS58_4316 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) APS58_4321 ENOG4105K2J Transcriptional regulator APS58_4322 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family APS58_4323 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter APS58_4324 ENOG4105CG6 trap dicarboxylate transporter dctm subunit APS58_4325 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit APS58_4326 ENOG4105C01 Dihydroxy-acid dehydratase APS58_4327 ENOG4108UHU Aldolase APS58_4329 ENOG4108UYE Lactoylglutathione lyase APS58_4330 ENOG4105CHR reductase APS58_4338 ENOG4108JJB ABC transporter APS58_4340 ENOG4105DZ2 Transcriptional regulator APS58_4341 ENOG4108UZX fmn reductase APS58_4344 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) APS58_4349 ENOG4105D3G Pseudouridine synthase APS58_4350 ENOG41066T0 asmA family APS58_4351 ENOG4105C0B DNA polymerase III (alpha subunit) APS58_4354 ENOG4105F0N pyrophosphate phospho-hydrolase APS58_4359 ENOG4105C26 Dehydrogenase APS58_4361 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) APS58_4364 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) APS58_4365 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) APS58_4367 ENOG4105CVM Molybdenum cofactor synthesis domain protein APS58_4370 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) APS58_4371 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) APS58_4372 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) APS58_4373 ENOG4105E9H Lytic Murein transglycosylase APS58_4377 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) APS58_4378 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) APS58_4379 ENOG4107QMP dna polymerase iii subunits gamma and tau APS58_4380 ENOG4105C8Q Methyl-accepting chemotaxis APS58_4381 ENOG4105CBX hi0933 family APS58_4382 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation APS58_4384 ENOG4105K63 Thioredoxin APS58_4385 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) APS58_4386 ENOG4105EYH Exonuclease APS58_4387 ENOG4107RH8 nuclease SbcCD subunit D APS58_4388 ENOG4105NRA 50s ribosomal protein l31 type b APS58_4390 ENOG4107QI1 Mate efflux family protein APS58_4391 ENOG4105BZU Histidine kinase APS58_4392 ENOG4105CK6 Two component transcriptional regulator (Winged helix family APS58_4393 ENOG4108UTW Plays a role in the regulation of phosphate uptake APS58_4394 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) APS58_4395 ENOG4105E2Z phosphate ABC transporter (Permease APS58_4396 ENOG4105C8U phosphate abc transporter APS58_4397 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) APS58_4398 ENOG4105C9X ppx gppa phosphatase APS58_4401 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) APS58_4403 ENOG4105BZU Histidine kinase APS58_4404 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) APS58_4405 ENOG4105EEI dihydropteroate synthase APS58_4406 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) APS58_4407 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) APS58_4408 ENOG4105HBR Rna-binding protein APS58_4411 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) APS58_4412 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain APS58_4415 ENOG4105C85 amino acid APS58_4418 ENOG4105C26 Dehydrogenase APS58_4420 ENOG4105C1G acyl-Coa dehydrogenase APS58_4422 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase APS58_4423 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) APS58_4424 ENOG4105CHB tonB-dependent Receptor APS58_4427 ENOG4105CTX dehydratase APS58_4428 ENOG4105CG6 trap dicarboxylate transporter dctm subunit APS58_4430 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit APS58_4432 ENOG4105E9Z Nad-dependent epimerase dehydratase APS58_4435 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase APS58_4443 ENOG4108Z4X TRANSCRIPTIONal APS58_4444 ENOG4105C0R drug resistance transporter emrb qaca subfamily APS58_4447 ENOG4105VSH 4-oxalocrotonate tautomerase APS58_4448 ENOG4108K3A Glutathione S-transferase APS58_4449 ENOG4105EXG Transcriptional regulator APS58_4454 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) APS58_4455 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) APS58_4457 ENOG4108ZZF transport protein (ExbD) APS58_4458 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) APS58_4459 ENOG4105W49 UPF0434 protein APS58_4460 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) APS58_4461 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) APS58_p00006 ENOG4105EGP transfer protein APS58_p00010 ENOG4107QKZ Ompa motb domain protein APS58_p00050 ENOG4105FA0 parb-like partition protein APS58_p00056 ENOG4105KT5 UmuD protein