locus-tag	class	description
FRC75_00085	COG1960	acyl-CoA dehydrogenase activity
FRC75_00095	COG1024	Enoyl-CoA hydratase
FRC75_00095	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRC75_00105	COG0183	Belongs to the thiolase family
FRC75_00115	COG1024	Enoyl-CoA hydratase
FRC75_00120	COG3181	Tripartite tricarboxylate transporter family receptor
FRC75_00135	COG5265	(ABC) transporter
FRC75_00140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FRC75_00145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FRC75_00145	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FRC75_00150	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FRC75_00155	COG0583	DNA-binding transcription factor activity
FRC75_00165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRC75_00170	COG0765	amino acid transport
FRC75_00175	COG0765	amino acid transport
FRC75_00180	COG1126	abc transporter atp-binding protein
FRC75_00210	COG2076	Multidrug Resistance protein
FRC75_00220	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FRC75_00230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FRC75_00255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FRC75_00260	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FRC75_00265	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRC75_00265	COG0515	serine threonine protein kinase
FRC75_00270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FRC75_00275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FRC75_00290	COG0316	Belongs to the HesB IscA family
FRC75_00295	COG2814	Major facilitator Superfamily
FRC75_00300	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FRC75_00310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FRC75_00315	COG0583	DNA-binding transcription factor activity
FRC75_00340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRC75_00345	COG2205	protein histidine kinase activity
FRC75_00365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRC75_00370	COG3002	Belongs to the UPF0753 family
FRC75_00380	COG2267	carboxylic ester hydrolase activity
FRC75_00405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRC75_00415	COG2855	membrane
FRC75_00420	COG0583	DNA-binding transcription factor activity
FRC75_00425	COG0737	Belongs to the 5'-nucleotidase family
FRC75_00465	COG2080	2 iron, 2 sulfur cluster binding
FRC75_00470	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FRC75_00475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FRC75_00495	COG3209	COG3209 Rhs family protein
FRC75_00495	COG3209	COG3209 Rhs family protein
FRC75_00515	COG0514	ATP-dependent DNA helicase (RecQ)
FRC75_00525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRC75_00530	COG0601	transmembrane transport
FRC75_00565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FRC75_00580	COG0745	RESPONSE REGULATOR receiver
FRC75_00585	COG0753	catalase activity
FRC75_00600	COG3145	DNA-N1-methyladenine dioxygenase activity
FRC75_00630	COG3045	CreA protein
FRC75_00635	COG1181	Belongs to the D-alanine--D-alanine ligase family
FRC75_00635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FRC75_00640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FRC75_00640	COG0189	ligase activity
FRC75_00645	COG1132	(ABC) transporter
FRC75_00680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRC75_00710	COG0346	lactoylglutathione lyase activity
FRC75_00725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRC75_00790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRC75_00820	COG1414	Transcriptional regulator
FRC75_00830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FRC75_00835	COG0183	Belongs to the thiolase family
FRC75_00840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRC75_00860	COG2031	fatty acid transporter
FRC75_00870	COG3181	Tripartite tricarboxylate transporter family receptor
FRC75_00875	COG3387	PFAM Glycoside hydrolase 15-related
FRC75_00895	COG2010	Cytochrome c
FRC75_00895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FRC75_00900	COG1335	isochorismatase
FRC75_00905	COG2309	aminopeptidase activity
FRC75_00910	COG0596	Alpha beta hydrolase
FRC75_00915	COG3473	Maleate cis-trans isomerase
FRC75_00925	COG2080	2 iron, 2 sulfur cluster binding
FRC75_00930	COG2010	Cytochrome c
FRC75_00930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FRC75_00935	COG0477	Major facilitator Superfamily
FRC75_00940	COG0840	transmembrane signaling receptor activity
FRC75_00945	COG1846	Transcriptional regulator
FRC75_00950	COG3038	cytochrome b561
FRC75_00970	COG4774	siderophore transport
FRC75_00980	COG1280	lysine exporter protein (LysE YggA)
FRC75_00985	COG1192	Involved in chromosome partitioning
FRC75_01000	COG0583	DNA-binding transcription factor activity
FRC75_01005	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FRC75_01010	COG1040	competence protein
FRC75_01015	COG2226	methyltransferase
FRC75_01060	COG1612	heme a metabolic process
FRC75_01065	COG0109	protoheme IX farnesyltransferase activity
FRC75_01070	COG1999	signal sequence binding
FRC75_01090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRC75_01100	COG0583	DNA-binding transcription factor activity
FRC75_01110	COG3842	ATPase activity
FRC75_01140	COG0534	Mate efflux family protein
FRC75_01155	COG4977	sequence-specific DNA binding
FRC75_01160	COG0840	transmembrane signaling receptor activity
FRC75_01185	COG0179	Fumarylacetoacetate (FAA) hydrolase
FRC75_01195	COG0612	Peptidase, M16
FRC75_01200	COG0612	Peptidase, M16
FRC75_01205	COG0742	ribosomal rna small subunit methyltransferase
FRC75_01210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FRC75_01235	COG5487	UPF0391 membrane protein
FRC75_01245	COG2197	response regulator
FRC75_01255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FRC75_01260	COG0793	Belongs to the peptidase S41A family
FRC75_01265	COG0588	phosphoglycerate mutase activity
FRC75_01270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FRC75_01280	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FRC75_01285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FRC75_01290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FRC75_01295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FRC75_01305	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FRC75_01330	COG0720	synthase
FRC75_01335	COG0602	queuosine metabolic process
FRC75_01340	COG0156	8-amino-7-oxononanoate synthase activity
FRC75_01345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FRC75_01355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FRC75_01385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRC75_01385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRC75_01390	COG0028	Belongs to the TPP enzyme family
FRC75_01405	COG0489	protein tyrosine kinase activity
FRC75_01410	COG2223	nitrite transmembrane transporter activity
FRC75_01415	COG0840	transmembrane signaling receptor activity
FRC75_01420	COG0243	molybdopterin cofactor binding
FRC75_01425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FRC75_01435	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FRC75_01480	COG0154	amidase activity
FRC75_01490	COG1802	Transcriptional regulator
FRC75_01500	COG3916	Acyl-homoserine-lactone synthase
FRC75_01505	COG2771	luxR family
FRC75_01535	COG0318	PFAM AMP-dependent synthetase and ligase
FRC75_01540	COG0534	Mate efflux family protein
FRC75_01555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRC75_01580	COG3209	COG3209 Rhs family protein
FRC75_01635	COG0737	Belongs to the 5'-nucleotidase family
FRC75_01660	COG1193	negative regulation of DNA recombination
FRC75_01680	COG2003	Belongs to the UPF0758 family
FRC75_01685	COG1047	Peptidyl-prolyl cis-trans
FRC75_01690	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FRC75_01695	COG1253	flavin adenine dinucleotide binding
FRC75_01700	COG0617	tRNA 3'-terminal CCA addition
FRC75_01700	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FRC75_01700	COG0517	IMP dehydrogenase activity
FRC75_01705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FRC75_01710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FRC75_01755	COG0129	dihydroxy-acid dehydratase activity
FRC75_01770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRC75_01775	COG0765	amino acid transport
FRC75_01780	COG0765	amino acid transport
FRC75_01785	COG0612	Peptidase, M16
FRC75_01830	COG0038	chloride channel
FRC75_01885	COG0443	Heat shock 70 kDa protein
FRC75_01940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRC75_01945	COG4774	siderophore transport
FRC75_01960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FRC75_02005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRC75_02050	COG0180	Tryptophanyl-tRNA synthetase
FRC75_02055	COG1994	Peptidase M50
FRC75_02065	COG0009	L-threonylcarbamoyladenylate synthase
FRC75_02070	COG0613	PHP domain protein
FRC75_02075	COG0738	Major facilitator superfamily
FRC75_02090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRC75_02100	COG4591	ABC-type transport system involved in lipoprotein release permease component
FRC75_02110	COG1136	(ABC) transporter
FRC75_02115	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FRC75_02120	COG1970	mechanosensitive ion channel activity
FRC75_02125	COG0723	plastoquinol--plastocyanin reductase activity
FRC75_02130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRC75_02135	COG2857	Cytochrome c1
FRC75_02140	COG0625	glutathione transferase activity
FRC75_02145	COG2969	positive regulation of protein catabolic process
FRC75_02160	COG0739	heme binding
FRC75_02165	COG0653	protein targeting
FRC75_02170	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FRC75_02180	COG0494	nUDIX hydrolase
FRC75_02185	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FRC75_02190	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FRC75_02195	COG0237	dephospho-CoA kinase activity
FRC75_02225	COG1473	amidohydrolase
FRC75_02235	COG0142	geranyltranstransferase activity
FRC75_02240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FRC75_02245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FRC75_02250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FRC75_02255	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FRC75_02260	COG0494	nUDIX hydrolase
FRC75_02265	COG0442	prolyl-tRNA aminoacylation
FRC75_02275	COG1253	flavin adenine dinucleotide binding
FRC75_02280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FRC75_02285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FRC75_02295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FRC75_02300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FRC75_02320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FRC75_02335	COG1511	domain protein
FRC75_02335	COG3264	Mechanosensitive ion channel
FRC75_02340	COG0584	glycerophosphoryl diester phosphodiesterase
FRC75_02350	COG3842	ATPase activity
FRC75_02355	COG0395	ABC-type sugar transport system, permease component
FRC75_02360	COG1175	transmembrane transport
FRC75_02365	COG1653	transport
FRC75_02370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FRC75_02395	COG2226	methyltransferase
FRC75_02410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRC75_02430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FRC75_02440	COG0494	nUDIX hydrolase
FRC75_02445	COG0745	RESPONSE REGULATOR receiver
FRC75_02455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRC75_02460	COG0302	gtp cyclohydrolase
FRC75_02490	COG1609	Transcriptional regulator
FRC75_02520	COG0747	negative chemotaxis
FRC75_02530	COG4608	Belongs to the ABC transporter superfamily
FRC75_02535	COG0444	Belongs to the ABC transporter superfamily
FRC75_02540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRC75_02550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FRC75_02555	COG0193	aminoacyl-tRNA hydrolase activity
FRC75_02560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FRC75_02565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRC75_02575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FRC75_02590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FRC75_02600	COG1194	a g-specific adenine glycosylase
FRC75_02605	COG1660	Displays ATPase and GTPase activities
FRC75_02610	COG0497	DNA recombination
FRC75_02615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRC75_02660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FRC75_02665	COG1420	regulation of RNA biosynthetic process
FRC75_02675	COG2197	response regulator
FRC75_02680	COG3693	PFAM glycoside hydrolase, family 10
FRC75_02710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRC75_02715	COG1758	RNA polymerase activity
FRC75_02720	COG0194	GDP metabolic process
FRC75_02725	COG1561	YicC-like family, N-terminal region
FRC75_02745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FRC75_02750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FRC75_02765	COG4221	oxidoreductase activity
FRC75_02770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FRC75_02785	COG1595	DNA-templated transcription, initiation
FRC75_02810	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FRC75_02815	COG0784	Response regulator, receiver
FRC75_02815	COG4191	Histidine kinase
FRC75_02860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRC75_02860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRC75_02885	COG4968	Prepilin-type N-terminal cleavage methylation domain
FRC75_02890	COG4968	Prepilin-type N-terminal cleavage methylation domain
FRC75_02930	COG2205	protein histidine kinase activity
FRC75_02960	COG0464	growth
FRC75_02975	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FRC75_02980	COG0830	nickel cation binding
FRC75_02985	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FRC75_02995	COG0804	urea catabolic process
FRC75_03000	COG0832	Belongs to the urease beta subunit family
FRC75_03010	COG0831	urea catabolic process
FRC75_03025	COG5001	Diguanylate cyclase
FRC75_03050	COG1304	FMN binding
FRC75_03055	COG2205	protein histidine kinase activity
FRC75_03075	COG2814	Major facilitator Superfamily
FRC75_03080	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FRC75_03085	COG4336	lyase activity
FRC75_03090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FRC75_03095	COG4770	biotin carboxylase activity
FRC75_03110	COG3038	cytochrome b561
FRC75_03130	COG5599	Phosphatase
FRC75_03135	COG1301	dicarboxylic acid transport
FRC75_03185	COG2814	Major facilitator Superfamily
FRC75_03295	COG0697	spore germination
FRC75_03325	COG0583	DNA-binding transcription factor activity
FRC75_03340	COG1283	sodium-dependent phosphate transmembrane transporter activity
FRC75_03345	COG3039	Transposase
FRC75_03355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FRC75_03360	COG3842	ATPase activity
FRC75_03365	COG1177	transmembrane transport
FRC75_03370	COG4149	molybdate abc transporter
FRC75_03380	COG1609	Transcriptional regulator
FRC75_03390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FRC75_03400	COG0196	riboflavin kinase activity
FRC75_03410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FRC75_03420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FRC75_03425	COG0840	transmembrane signaling receptor activity
FRC75_03430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRC75_03450	COG1960	acyl-CoA dehydrogenase activity
FRC75_03455	COG3132	Protein of unknown function, DUF480
FRC75_03460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FRC75_03475	COG3866	Pectate lyase
FRC75_03480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FRC75_03480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FRC75_03495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRC75_03500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FRC75_03505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FRC75_03510	COG0492	ferredoxin-NADP+ reductase activity
FRC75_03515	COG1674	ftsk spoiiie
FRC75_03520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FRC75_03535	COG1573	uracil-dna glycosylase
FRC75_03540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FRC75_03545	COG0840	transmembrane signaling receptor activity
FRC75_03550	COG0559	Belongs to the binding-protein-dependent transport system permease family
FRC75_03570	COG2885	chlorophyll binding
FRC75_03570	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FRC75_03575	COG1392	Phosphate transport regulator
FRC75_03580	COG0306	phosphate transporter
FRC75_03595	COG0228	four-way junction DNA binding
FRC75_03600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FRC75_03605	COG0336	Belongs to the RNA methyltransferase TrmD family
FRC75_03610	COG0335	large ribosomal subunit rRNA binding
FRC75_03620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FRC75_03625	COG1162	GTPase activity
FRC75_03630	COG2154	pterin-4-alpha-carbinolamine dehydratase
FRC75_03640	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FRC75_03645	COG0513	Belongs to the DEAD box helicase family
FRC75_03650	COG5002	protein histidine kinase activity
FRC75_03650	COG3447	MASE1 domain protein
FRC75_03650	COG5001	Diguanylate cyclase
FRC75_03655	COG2814	Major facilitator Superfamily
FRC75_03670	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FRC75_03675	COG5002	protein histidine kinase activity
FRC75_03680	COG2204	response regulator
FRC75_03730	COG0516	GMP reductase activity
FRC75_03815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FRC75_03855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRC75_03860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRC75_03890	COG0412	Dienelactone hydrolase
FRC75_03900	COG0165	Argininosuccinate lyase
FRC75_03915	COG3275	phosphorelay sensor kinase activity
FRC75_03920	COG0165	Argininosuccinate lyase
FRC75_03960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRC75_03970	COG1304	FMN binding
FRC75_03975	COG0840	transmembrane signaling receptor activity
FRC75_03995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FRC75_04025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FRC75_04030	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FRC75_04040	COG0617	tRNA 3'-terminal CCA addition
FRC75_04080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRC75_04085	COG1960	acyl-CoA dehydrogenase activity
FRC75_04090	COG0583	DNA-binding transcription factor activity
FRC75_04125	COG2816	NAD+ diphosphatase activity
FRC75_04130	COG0425	Belongs to the sulfur carrier protein TusA family
FRC75_04140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FRC75_04145	COG0525	valine-tRNA ligase activity
FRC75_04150	COG0501	Belongs to the peptidase M48B family
FRC75_04160	COG0488	(ABC) transporter
FRC75_04180	COG0181	hydroxymethylbilane synthase activity
FRC75_04185	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FRC75_04190	COG1289	transmembrane transporter activity
FRC75_04195	COG0628	permease
FRC75_04250	COG1722	exodeoxyribonuclease VII activity
FRC75_04255	COG0142	geranyltranstransferase activity
FRC75_04260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FRC75_04265	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FRC75_04290	COG0668	transmembrane transport
FRC75_04295	COG0366	Alpha amylase catalytic
FRC75_04300	COG0366	Alpha amylase catalytic
FRC75_04305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FRC75_04310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRC75_04315	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FRC75_04335	COG3585	molybdate ion transport
FRC75_04335	COG2005	Transcriptional regulator
FRC75_04360	COG3279	Response regulator of the LytR AlgR family
FRC75_04365	COG3275	phosphorelay sensor kinase activity
FRC75_04405	COG1968	undecaprenyl-diphosphatase activity
FRC75_04410	COG3447	MASE1 domain protein
FRC75_04410	COG5002	protein histidine kinase activity
FRC75_04410	COG5001	Diguanylate cyclase
FRC75_04450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FRC75_04455	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRC75_04510	COG5002	protein histidine kinase activity
FRC75_04510	COG0784	Response regulator, receiver
FRC75_04510	COG2205	protein histidine kinase activity
FRC75_04515	COG3437	response regulator, receiver
FRC75_04525	COG1132	(ABC) transporter
FRC75_04540	COG0483	inositol monophosphate 1-phosphatase activity
FRC75_04555	COG4555	ABC transporter
FRC75_04560	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FRC75_04570	COG1045	serine acetyltransferase
FRC75_04575	COG0521	Mo-molybdopterin cofactor biosynthetic process
FRC75_04580	COG3028	Belongs to the UPF0307 family
FRC75_04585	COG0312	modulator of DNA gyrase
FRC75_04600	COG2721	sulfolactate sulfo-lyase activity
FRC75_04615	COG0477	Major facilitator Superfamily
FRC75_04620	COG1752	Esterase of the alpha-beta hydrolase superfamily
FRC75_04625	COG0473	3-isopropylmalate dehydrogenase activity
FRC75_04630	COG0583	DNA-binding transcription factor activity
FRC75_04640	COG0625	glutathione transferase activity
FRC75_04645	COG1610	YqeY-like protein
FRC75_04650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FRC75_04670	COG0640	Transcriptional regulator
FRC75_04675	COG2081	HI0933 family
FRC75_04690	COG0288	reversible hydration of carbon dioxide
FRC75_04695	COG1607	acyl-coa hydrolase
FRC75_04700	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FRC75_04700	COG5297	Belongs to the glycosyl hydrolase family 6
FRC75_04710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRC75_04715	COG0243	molybdopterin cofactor binding
FRC75_04725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRC75_04730	COG0840	transmembrane signaling receptor activity
FRC75_04745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRC75_04755	COG0840	transmembrane signaling receptor activity
FRC75_04760	COG0516	GMP reductase activity
FRC75_04760	COG0517	IMP dehydrogenase activity
FRC75_04765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRC75_04785	COG0840	transmembrane signaling receptor activity
FRC75_04795	COG0745	RESPONSE REGULATOR receiver
FRC75_04810	COG2223	nitrite transmembrane transporter activity
FRC75_04875	COG0626	cystathionine gamma-synthase activity
FRC75_04885	COG0724	RNA recognition motif
FRC75_04900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FRC75_04905	COG1116	anion transmembrane transporter activity
FRC75_04910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRC75_04915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRC75_04935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FRC75_04950	COG0683	leucine binding
FRC75_04980	COG2951	lytic endotransglycosylase activity
FRC75_04995	COG0714	Associated with various cellular activities
FRC75_05000	COG0123	including yeast histone deacetylase and acetoin utilization protein
FRC75_05005	COG1024	Enoyl-CoA hydratase
FRC75_05015	COG1511	domain protein
FRC75_05015	COG3264	Mechanosensitive ion channel
FRC75_05030	COG1960	acyl-CoA dehydrogenase activity
FRC75_05075	COG1473	amidohydrolase
FRC75_05080	COG1522	sequence-specific DNA binding
FRC75_05090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FRC75_05110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRC75_05125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRC75_05135	COG0473	3-isopropylmalate dehydrogenase activity
FRC75_05145	COG2194	sulfuric ester hydrolase activity
FRC75_05150	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FRC75_05160	COG4977	sequence-specific DNA binding
FRC75_05165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FRC75_05175	COG0372	Belongs to the citrate synthase family
FRC75_05180	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FRC75_05185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FRC75_05190	COG1053	succinate dehydrogenase
FRC75_05205	COG2188	Transcriptional regulator
FRC75_05210	COG0039	L-malate dehydrogenase activity
FRC75_05215	COG4106	trans-aconitate 2-methyltransferase activity
FRC75_05230	COG1049	propionate catabolic process, 2-methylcitrate cycle
FRC75_05235	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FRC75_05250	COG0826	peptidase U32
FRC75_05255	COG0583	DNA-binding transcription factor activity
FRC75_05280	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FRC75_05285	COG1845	cytochrome c oxidase, subunit III
FRC75_05290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRC75_05295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FRC75_05300	COG0477	Major facilitator Superfamily
FRC75_05320	COG0824	Thioesterase
FRC75_05325	COG0436	Aminotransferase
FRC75_05330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FRC75_05335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FRC75_05350	COG0633	Ferredoxin
FRC75_05360	COG2205	protein histidine kinase activity
FRC75_05360	COG2202	Pas domain
FRC75_05370	COG0745	RESPONSE REGULATOR receiver
FRC75_05375	COG2201	protein-glutamate methylesterase activity
FRC75_05395	COG1289	transmembrane transporter activity
FRC75_05400	COG4948	Mandelate Racemase Muconate Lactonizing
FRC75_05405	COG0800	Aldolase
FRC75_05410	COG3734	2-keto-3-deoxy-galactonokinase
FRC75_05430	COG1172	Belongs to the binding-protein-dependent transport system permease family
FRC75_05435	COG1172	Belongs to the binding-protein-dependent transport system permease family
FRC75_05445	COG4214	carbohydrate transport
FRC75_05455	COG4213	ABC transporter substrate-binding protein
FRC75_05460	COG1879	ABC-type sugar transport system periplasmic component
FRC75_05480	COG3386	PFAM SMP-30 Gluconolaconase
FRC75_05490	COG2918	glutathione biosynthetic process
FRC75_05500	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRC75_05515	COG5002	protein histidine kinase activity
FRC75_05530	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FRC75_05550	COG2814	Major facilitator Superfamily
FRC75_05565	COG1285	pathogenesis
FRC75_05570	COG0564	pseudouridine synthase activity
FRC75_05595	COG1653	transport
FRC75_05600	COG0840	transmembrane signaling receptor activity
FRC75_05630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRC75_05665	COG1309	transcriptional regulator
FRC75_05680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRC75_05690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FRC75_05705	COG3384	dioxygenase
FRC75_05725	COG1522	sequence-specific DNA binding
FRC75_05780	COG0215	cysteine-tRNA ligase activity
FRC75_05795	COG0037	tRNA processing
FRC75_05800	COG0527	aspartate kinase activity
FRC75_05860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FRC75_05870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FRC75_05975	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FRC75_06020	COG3181	Tripartite tricarboxylate transporter family receptor
FRC75_06025	COG0154	amidase activity
FRC75_06045	COG1739	Uncharacterized protein family UPF0029
FRC75_06060	COG0840	transmembrane signaling receptor activity
FRC75_06075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRC75_06085	COG0556	nucleotide-excision repair
FRC75_06090	COG1959	2 iron, 2 sulfur cluster binding
FRC75_06095	COG1104	cysteine desulfurase activity
FRC75_06100	COG0822	iron-sulfur transferase activity
FRC75_06110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FRC75_06115	COG0443	Heat shock 70 kDa protein
FRC75_06120	COG0633	Ferredoxin
FRC75_06145	COG0579	oxidoreductase
FRC75_06165	COG0167	dihydroorotate dehydrogenase activity
FRC75_06170	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FRC75_06185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FRC75_06190	COG4566	intracellular signal transduction
FRC75_06200	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FRC75_06205	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRC75_06210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRC75_06240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FRC75_06245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRC75_06255	COG0515	serine threonine protein kinase
FRC75_06285	COG3243	poly(R)-hydroxyalkanoic acid synthase
FRC75_06290	COG0183	Belongs to the thiolase family
FRC75_06295	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_06300	COG0488	(ABC) transporter
FRC75_06305	COG2890	protein-(glutamine-N5) methyltransferase activity
FRC75_06310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRC75_06320	COG2171	N-acyltransferase activity
FRC75_06330	COG0840	transmembrane signaling receptor activity
FRC75_06335	COG2878	Part of a membrane complex involved in electron transport
FRC75_06355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRC75_06370	COG3039	Transposase
FRC75_06385	COG0840	transmembrane signaling receptor activity
FRC75_06450	COG1802	Transcriptional regulator
FRC75_06455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FRC75_06455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FRC75_06465	COG1703	isobutyryl-CoA mutase activity
FRC75_06470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRC75_06480	COG4770	biotin carboxylase activity
FRC75_06500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FRC75_06545	COG5002	protein histidine kinase activity
FRC75_06560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRC75_06575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FRC75_06580	COG0583	DNA-binding transcription factor activity
FRC75_06585	COG2814	Major facilitator Superfamily
FRC75_06595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FRC75_06600	COG2011	ABC-type metal ion transport system permease component
FRC75_06620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FRC75_06640	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FRC75_06645	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FRC75_06650	COG4208	sulfate ABC transporter
FRC75_06655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FRC75_06660	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FRC75_06665	COG1054	Belongs to the UPF0176 family
FRC75_06680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FRC75_06680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FRC75_06685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRC75_06695	COG1643	Atp-dependent helicase
FRC75_06705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FRC75_06710	COG0252	asparaginase activity
FRC75_06725	COG0563	adenylate kinase activity
FRC75_06730	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FRC75_06735	COG2835	tetraacyldisaccharide 4'-kinase activity
FRC75_06740	COG1663	tetraacyldisaccharide 4'-kinase activity
FRC75_06745	COG0848	biopolymer transport protein
FRC75_06750	COG0811	peptide transport
FRC75_06755	COG1570	exodeoxyribonuclease VII activity
FRC75_06760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FRC75_06790	COG0625	glutathione transferase activity
FRC75_06795	COG1942	4-Oxalocrotonate Tautomerase
FRC75_06810	COG2814	Major facilitator Superfamily
FRC75_06815	COG0789	Transcriptional regulator
FRC75_06855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRC75_06860	COG3181	Tripartite tricarboxylate transporter family receptor
FRC75_06870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRC75_06880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FRC75_06895	COG2721	sulfolactate sulfo-lyase activity
FRC75_06910	COG4772	TonB-dependent receptor
FRC75_06915	COG2032	superoxide dismutase activity
FRC75_06930	COG1960	acyl-CoA dehydrogenase activity
FRC75_06960	COG1113	amino acid transport
FRC75_06970	COG0505	Belongs to the CarA family
FRC75_06975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FRC75_06980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRC75_06995	COG1534	Rna-binding protein
FRC75_07000	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FRC75_07005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRC75_07015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRC75_07045	COG0248	Ppx GppA phosphatase
FRC75_07050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FRC75_07055	COG0573	inorganic phosphate transmembrane transporter activity
FRC75_07060	COG0581	inorganic phosphate transmembrane transporter activity
FRC75_07065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FRC75_07070	COG0704	Plays a role in the regulation of phosphate uptake
FRC75_07085	COG0534	Mate efflux family protein
FRC75_07095	COG0254	rRNA binding
FRC75_07100	COG0420	3'-5' exonuclease activity
FRC75_07105	COG0419	ATPase involved in DNA repair
FRC75_07110	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FRC75_07125	COG1074	ATP-dependent DNA helicase activity
FRC75_07130	COG2081	HI0933 family
FRC75_07145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FRC75_07150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FRC75_07155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FRC75_07175	COG0741	lytic transglycosylase activity
FRC75_07175	COG1388	LysM domain
FRC75_07180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRC75_07185	COG2226	methyltransferase
FRC75_07190	COG0328	RNA-DNA hybrid ribonuclease activity
FRC75_07205	COG0303	'Molybdopterin
FRC75_07215	COG0746	molybdenum cofactor guanylyltransferase activity
FRC75_07220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FRC75_07245	COG1012	belongs to the aldehyde dehydrogenase family
FRC75_07270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FRC75_07285	COG0587	DNA-directed DNA polymerase activity
FRC75_07290	COG2982	Protein involved in outer membrane biogenesis
FRC75_07295	COG0564	pseudouridine synthase activity
FRC75_07305	COG2894	cell division
FRC75_07365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRC75_07450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FRC75_07470	COG3318	Belongs to the UPF0149 family
FRC75_07470	COG3012	SEC-C Motif Domain Protein
FRC75_07545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FRC75_07560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FRC75_07580	COG0739	heme binding
FRC75_07580	COG0741	lytic transglycosylase activity
FRC75_07580	COG1196	nuclear chromosome segregation
FRC75_07600	COG4974	Belongs to the 'phage' integrase family
FRC75_07610	COG0587	DNA-directed DNA polymerase activity
FRC75_07695	COG4453	Protein conserved in bacteria
FRC75_07805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRC75_07865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FRC75_07875	COG0431	NADPH-dependent FMN reductase
FRC75_07880	COG0583	DNA-binding transcription factor activity
FRC75_07920	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_07925	COG0346	lactoylglutathione lyase activity
FRC75_07935	COG0800	Aldolase
FRC75_07945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FRC75_07950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FRC75_07955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FRC75_07960	COG3265	gluconokinase activity
FRC75_07965	COG1609	Transcriptional regulator
FRC75_07990	COG0259	pyridoxamine-phosphate oxidase activity
FRC75_08005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRC75_08010	COG4771	TonB-dependent receptor
FRC75_08035	COG1136	(ABC) transporter
FRC75_08045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FRC75_08050	COG1309	transcriptional regulator
FRC75_08070	COG0045	succinate-CoA ligase (ADP-forming) activity
FRC75_08070	COG1042	CoA-binding domain protein
FRC75_08070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FRC75_08120	COG2133	pyrroloquinoline quinone binding
FRC75_08125	COG0791	NLP P60 protein
FRC75_08140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRC75_08170	COG3209	COG3209 Rhs family protein
FRC75_08185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FRC75_08195	COG1196	nuclear chromosome segregation
FRC75_08205	COG1742	UPF0060 membrane protein
FRC75_08215	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FRC75_08220	COG1132	(ABC) transporter
FRC75_08245	COG0789	Transcriptional regulator
FRC75_08250	COG0776	regulation of translation
FRC75_08255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRC75_08255	COG0072	phenylalanine-tRNA ligase activity
FRC75_08260	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FRC75_08265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FRC75_08270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FRC75_08275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FRC75_08280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FRC75_08285	COG2224	Isocitrate lyase
FRC75_08300	COG1522	sequence-specific DNA binding
FRC75_08305	COG0697	spore germination
FRC75_08315	COG1840	ABC-type Fe3 transport system, periplasmic component
FRC75_08335	COG2153	protein acetylation
FRC75_08340	COG2130	NADP-dependent
FRC75_08365	COG1960	acyl-CoA dehydrogenase activity
FRC75_08370	COG2050	protein possibly involved in aromatic compounds catabolism
FRC75_08375	COG0183	Belongs to the thiolase family
FRC75_08380	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRC75_08380	COG1024	Enoyl-CoA hydratase
FRC75_08635	COG3706	GGDEF domain
FRC75_08660	COG0411	ABC transporter
FRC75_08670	COG0559	Belongs to the binding-protein-dependent transport system permease family
FRC75_08680	COG0318	PFAM AMP-dependent synthetase and ligase
FRC75_08685	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FRC75_08690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FRC75_08695	COG2917	probably involved in intracellular septation
FRC75_08705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRC75_08725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FRC75_08730	COG0688	phosphatidylethanolamine metabolic process
FRC75_08745	COG5006	permease, DMT superfamily
FRC75_08760	COG1228	amidohydrolase
FRC75_08775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FRC75_08780	COG2986	histidine ammonia-lyase
FRC75_08785	COG2188	Transcriptional regulator
FRC75_08795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRC75_08805	COG1366	Belongs to the anti-sigma-factor antagonist family
FRC75_08810	COG1366	Belongs to the anti-sigma-factor antagonist family
FRC75_08815	COG2172	sigma factor antagonist activity
FRC75_08825	COG2205	protein histidine kinase activity
FRC75_08830	COG2205	protein histidine kinase activity
FRC75_08835	COG0784	Response regulator, receiver
FRC75_08835	COG4191	Histidine kinase
FRC75_08865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FRC75_08885	COG0297	glycogen (starch) synthase activity
FRC75_08895	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_08900	COG0557	exoribonuclease II activity
FRC75_08925	COG0741	lytic transglycosylase activity
FRC75_08930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FRC75_08935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FRC75_08945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FRC75_08950	COG0517	IMP dehydrogenase activity
FRC75_08950	COG1125	glycine betaine transport
FRC75_08965	COG1011	Hydrolase
FRC75_08970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRC75_08975	COG5002	protein histidine kinase activity
FRC75_09025	COG3181	Tripartite tricarboxylate transporter family receptor
FRC75_09035	COG0642	Histidine kinase
FRC75_09050	COG0667	Aldo Keto reductase
FRC75_09055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FRC75_09060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRC75_09065	COG4181	ATPase activity
FRC75_09105	COG1054	Belongs to the UPF0176 family
FRC75_09110	COG1741	Belongs to the pirin family
FRC75_09120	COG1741	Belongs to the pirin family
FRC75_09125	COG0583	DNA-binding transcription factor activity
FRC75_09135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRC75_09140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FRC75_09150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FRC75_09170	COG0583	DNA-binding transcription factor activity
FRC75_09180	COG1116	anion transmembrane transporter activity
FRC75_09185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRC75_09195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRC75_09205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRC75_09215	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FRC75_09220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRC75_09220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FRC75_09240	COG0730	response to heat
FRC75_09255	COG0175	sulfate reduction
FRC75_09260	COG0529	Catalyzes the synthesis of activated sulfate
FRC75_09260	COG2895	sulfate adenylyltransferase (ATP) activity
FRC75_09265	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FRC75_09270	COG0492	ferredoxin-NADP+ reductase activity
FRC75_09315	COG0351	phosphomethylpyrimidine kinase
FRC75_09330	COG2022	thiamine diphosphate biosynthetic process
FRC75_09345	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRC75_09350	COG1024	Enoyl-CoA hydratase
FRC75_09365	COG1960	acyl-CoA dehydrogenase activity
FRC75_09380	COG1619	proteins homologs of microcin C7 resistance protein MccF
FRC75_09405	COG0826	peptidase U32
FRC75_09415	COG0823	Involved in the tonB-independent uptake of proteins
FRC75_09415	COG1506	peptidase
FRC75_09415	COG4946	Tricorn protease homolog
FRC75_09425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FRC75_09430	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FRC75_09445	COG3047	cAMP biosynthetic process
FRC75_09450	COG2354	Protein conserved in bacteria
FRC75_09455	COG3300	MHYT domain
FRC75_09455	COG5001	Diguanylate cyclase
FRC75_09470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRC75_09470	COG0047	phosphoribosylformylglycinamidine synthase activity
FRC75_09475	COG0024	Methionine aminopeptidase
FRC75_09480	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FRC75_09485	COG0242	peptide deformylase activity
FRC75_09490	COG2832	Protein of unknown function (DUF454)
FRC75_09505	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FRC75_09510	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FRC75_09515	COG1414	Transcriptional regulator
FRC75_09525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRC75_09530	COG1183	phosphatidylcholine synthase activity
FRC75_09535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FRC75_09540	COG0440	acetolactate synthase activity
FRC75_09545	COG0028	Belongs to the TPP enzyme family
FRC75_09550	COG1595	DNA-templated transcription, initiation
FRC75_09570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FRC75_09580	COG0347	Belongs to the P(II) protein family
FRC75_09595	COG0583	DNA-binding transcription factor activity
FRC75_09605	COG3181	Tripartite tricarboxylate transporter family receptor
FRC75_09610	COG0835	chemotaxis
FRC75_09635	COG1252	NADH dehydrogenase
FRC75_09645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FRC75_09680	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_09700	COG4120	Belongs to the binding-protein-dependent transport system permease family
FRC75_09715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FRC75_09720	COG0509	glycine decarboxylation via glycine cleavage system
FRC75_09725	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FRC75_09725	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FRC75_09730	COG0545	Peptidyl-prolyl cis-trans isomerase
FRC75_09740	COG0564	pseudouridine synthase activity
FRC75_09745	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_09760	COG0589	response to stress
FRC75_09775	COG0318	PFAM AMP-dependent synthetase and ligase
FRC75_09800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FRC75_09820	COG0583	DNA-binding transcription factor activity
FRC75_09825	COG0436	Aminotransferase
FRC75_09860	COG0683	leucine binding
FRC75_09870	COG1960	acyl-CoA dehydrogenase activity
FRC75_09875	COG1024	Enoyl-CoA hydratase
FRC75_09885	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_09900	COG0596	Alpha beta hydrolase
FRC75_09905	COG2205	protein histidine kinase activity
FRC75_09915	COG3593	DNA synthesis involved in DNA repair
FRC75_09920	COG0210	DNA helicase
FRC75_09955	COG1530	ribonuclease E activity
FRC75_09960	COG0424	maF-like protein
FRC75_09970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FRC75_09975	COG0799	negative regulation of ribosome biogenesis
FRC75_09980	COG0408	coproporphyrinogen oxidase activity
FRC75_09985	COG0151	Belongs to the GarS family
FRC75_09990	COG0217	transcriptional regulatory protein
FRC75_09995	COG0433	COG0433 Predicted ATPase
FRC75_10020	COG0277	FAD linked oxidase domain protein
FRC75_10025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FRC75_10050	COG0625	glutathione transferase activity
FRC75_10065	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FRC75_10085	COG0402	S-adenosylhomocysteine deaminase activity
FRC75_10120	COG0484	heat shock protein binding
FRC75_10130	COG1012	belongs to the aldehyde dehydrogenase family
FRC75_10150	COG3284	Transcriptional regulator
FRC75_10160	COG2925	Exonuclease
FRC75_10165	COG2951	lytic endotransglycosylase activity
FRC75_10170	COG0542	response to heat
FRC75_10175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FRC75_10190	COG1199	ATP-dependent helicase activity
FRC75_10205	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FRC75_10210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRC75_10215	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRC75_10220	COG0567	Dehydrogenase, E1 component
FRC75_10225	COG0628	permease
FRC75_10230	COG5001	Diguanylate cyclase
FRC75_10230	COG5002	protein histidine kinase activity
FRC75_10230	COG3447	MASE1 domain protein
FRC75_10235	COG4172	Belongs to the ABC transporter superfamily
FRC75_10240	COG4239	(ABC) transporter, permease
FRC75_10245	COG4174	ABC transporter (Permease)
FRC75_10250	COG4166	transmembrane transport
FRC75_10260	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FRC75_10380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRC75_10395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FRC75_10400	COG1605	Chorismate mutase
FRC75_10400	COG0077	Prephenate dehydratase
FRC75_10405	COG0287	Prephenate dehydrogenase
FRC75_10410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FRC75_10420	COG0776	regulation of translation
FRC75_10430	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FRC75_10435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRC75_10435	COG2111	Na H antiporter
FRC75_10440	COG1006	Multisubunit Na H antiporter MnhC subunit
FRC75_10445	COG0651	ATP synthesis coupled electron transport
FRC75_10455	COG2212	antiporter activity
FRC75_10490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FRC75_10515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FRC75_10520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FRC75_10525	COG0405	Gamma-glutamyltransferase
FRC75_10565	COG3193	protein, possibly involved in utilization of glycolate and propanediol
FRC75_10570	COG0670	Belongs to the BI1 family
FRC75_10580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FRC75_10595	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FRC75_10595	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FRC75_10595	COG0506	proline dehydrogenase activity
FRC75_10605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRC75_10615	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FRC75_10620	COG4774	siderophore transport
FRC75_10655	COG0494	nUDIX hydrolase
FRC75_10660	COG1278	Cold shock
FRC75_10675	COG0492	ferredoxin-NADP+ reductase activity
FRC75_10680	COG2226	methyltransferase
FRC75_10720	COG3209	COG3209 Rhs family protein
FRC75_10745	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_10755	COG0583	DNA-binding transcription factor activity
FRC75_10790	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FRC75_10830	COG0582	viral genome integration into host DNA
FRC75_10835	COG0519	Catalyzes the synthesis of GMP from XMP
FRC75_10835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRC75_10860	COG2914	Belongs to the UPF0125 (RnfH) family
FRC75_10870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FRC75_10890	COG1024	Enoyl-CoA hydratase
FRC75_10895	COG1253	flavin adenine dinucleotide binding
FRC75_10905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRC75_10910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FRC75_10915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FRC75_10920	COG0195	Participates in both transcription termination and antitermination
FRC75_10925	COG0779	Required for maturation of 30S ribosomal subunits
FRC75_10935	COG2010	Cytochrome c
FRC75_10935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FRC75_11005	COG2423	ornithine cyclodeaminase activity
FRC75_11025	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FRC75_11035	COG2885	chlorophyll binding
FRC75_11040	COG0823	Involved in the tonB-independent uptake of proteins
FRC75_11045	COG1132	(ABC) transporter
FRC75_11055	COG0084	hydrolase, TatD family'
FRC75_11070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FRC75_11075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FRC75_11090	COG0657	acetylesterase activity
FRC75_11100	COG1454	alcohol dehydrogenase
FRC75_11115	COG2183	response to ionizing radiation
FRC75_11140	COG2814	Major facilitator Superfamily
FRC75_11145	COG2814	Major facilitator Superfamily
FRC75_11185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRC75_11200	COG1286	toxin biosynthetic process
FRC75_11210	COG0285	dihydrofolate synthase activity
FRC75_11215	COG1393	Belongs to the ArsC family
FRC75_11225	COG3123	guanosine phosphorylase activity
FRC75_11230	COG0137	argininosuccinate synthase activity
FRC75_11240	COG1666	GTP binding
FRC75_11245	COG3577	Aspartyl protease
FRC75_11255	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FRC75_11260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FRC75_11265	COG0667	Aldo Keto reductase
FRC75_11270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FRC75_11285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRC75_11295	COG0308	aminopeptidase N
FRC75_11300	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FRC75_11310	COG0583	DNA-binding transcription factor activity
FRC75_11315	COG1960	acyl-CoA dehydrogenase activity
FRC75_11320	COG3181	Tripartite tricarboxylate transporter family receptor
FRC75_11325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRC75_11330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRC75_11335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRC75_11340	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRC75_11345	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRC75_11350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FRC75_11355	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRC75_11370	COG0750	zinc metalloprotease
FRC75_11375	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FRC75_11380	COG0575	Belongs to the CDS family
FRC75_11390	COG0233	cytoplasmic translational termination
FRC75_11395	COG0528	UMP kinase activity
FRC75_11400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FRC75_11405	COG0052	Belongs to the universal ribosomal protein uS2 family
FRC75_11410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRC75_11415	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FRC75_11415	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FRC75_11440	COG0789	Transcriptional regulator
FRC75_11470	COG2132	Multicopper oxidase
FRC75_11500	COG3191	aminopeptidase activity
FRC75_11515	COG0488	(ABC) transporter
FRC75_11520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FRC75_11530	COG0513	Belongs to the DEAD box helicase family
FRC75_11540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FRC75_11540	COG4651	solute:proton antiporter activity
FRC75_11620	COG1196	nuclear chromosome segregation
FRC75_12100	COG3728	DNA packaging
FRC75_12100	COG5484	DNA packaging
FRC75_12310	COG0322	excinuclease ABC activity
FRC75_12330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRC75_12335	COG0601	transmembrane transport
FRC75_12345	COG4172	Belongs to the ABC transporter superfamily
FRC75_12350	COG1446	asparaginase
FRC75_12370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRC75_12375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRC75_12390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FRC75_12410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRC75_12505	COG1196	nuclear chromosome segregation
FRC75_12660	COG1475	DNA binding
FRC75_12680	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
FRC75_12690	COG0693	protein deglycase activity
FRC75_12725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRC75_12735	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_12755	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FRC75_12755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FRC75_12760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FRC75_12760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FRC75_12765	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FRC75_12775	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FRC75_12785	COG0560	Phosphoserine phosphatase
FRC75_12800	COG0583	DNA-binding transcription factor activity
FRC75_12805	COG1959	2 iron, 2 sulfur cluster binding
FRC75_12830	COG0513	Belongs to the DEAD box helicase family
FRC75_12840	COG0667	Aldo Keto reductase
FRC75_12845	COG2900	Belongs to the SlyX family
FRC75_12850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRC75_12855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRC75_12870	COG0477	Major facilitator Superfamily
FRC75_12880	COG3039	Transposase
FRC75_12905	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FRC75_12910	COG1492	cobalamin metabolic process
FRC75_12915	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_12945	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FRC75_12950	COG0778	Nitroreductase
FRC75_12955	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FRC75_12960	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FRC75_12965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRC75_12980	COG1797	cobyrinic acid a,c-diamide synthase activity
FRC75_12985	COG4206	TonB-dependent receptor
FRC75_13005	COG3437	response regulator, receiver
FRC75_13015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FRC75_13020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRC75_13055	COG3278	Belongs to the heme-copper respiratory oxidase family
FRC75_13065	COG2217	Heavy metal translocating P-type atpase
FRC75_13075	COG0589	response to stress
FRC75_13085	COG3048	D-serine ammonia-lyase activity
FRC75_13090	COG0318	PFAM AMP-dependent synthetase and ligase
FRC75_13120	COG1802	Transcriptional regulator
FRC75_13125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FRC75_13140	COG0129	dihydroxy-acid dehydratase activity
FRC75_13150	COG4654	Cytochrome c, class I
FRC75_13170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRC75_13180	COG4175	Glycine betaine
FRC75_13185	COG4176	ABC-type proline glycine betaine transport system permease component
FRC75_13190	COG2113	Glycine betaine
FRC75_13195	COG2205	protein histidine kinase activity
FRC75_13200	COG0745	RESPONSE REGULATOR receiver
FRC75_13210	COG0114	fumarate hydratase activity
FRC75_13225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FRC75_13235	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FRC75_13240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FRC75_13245	COG1451	nucleotide metabolic process
FRC75_13310	COG2885	chlorophyll binding
FRC75_13325	COG0631	protein serine/threonine phosphatase activity
FRC75_13355	COG1562	ergosterol biosynthetic process
FRC75_13365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRC75_13375	COG0544	peptidyl-prolyl cis-trans isomerase activity
FRC75_13380	COG0740	serine-type endopeptidase activity
FRC75_13385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FRC75_13390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FRC75_13415	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FRC75_13430	COG0277	FAD linked oxidase domain protein
FRC75_13440	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FRC75_13455	COG0708	Exodeoxyribonuclease III
FRC75_13465	COG2204	response regulator
FRC75_13470	COG3852	Histidine kinase
FRC75_13480	COG0174	glutamine synthetase
FRC75_13510	COG1187	pseudouridine synthase activity
FRC75_13540	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FRC75_13545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FRC75_13550	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FRC75_13555	COG0330	HflC and HflK could
FRC75_13560	COG0330	HflC and HflK could
FRC75_13565	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FRC75_13570	COG1923	regulation of RNA biosynthetic process
FRC75_13575	COG1160	GTP binding
FRC75_13590	COG0124	histidyl-tRNA synthetase
FRC75_13595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FRC75_13605	COG3063	Type IV pilus biogenesis stability protein PilW
FRC75_13610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FRC75_13615	COG0105	UTP biosynthetic process
FRC75_13620	COG1187	pseudouridine synthase activity
FRC75_13625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FRC75_13630	COG0564	pseudouridine synthase activity
FRC75_13640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRC75_13645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FRC75_13650	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_13650	COG3321	synthase
FRC75_13650	COG0604	alcohol dehydrogenase
FRC75_13660	COG3540	Alkaline phosphatase
FRC75_13665	COG0405	Gamma-glutamyltransferase
FRC75_13670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FRC75_13675	COG3300	MHYT domain
FRC75_13675	COG5001	Diguanylate cyclase
FRC75_13680	COG0358	DNA primase activity
FRC75_13685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRC75_13690	COG0840	transmembrane signaling receptor activity
FRC75_13745	COG4948	Mandelate Racemase Muconate Lactonizing
FRC75_13750	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_13765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRC75_13770	COG0583	DNA-binding transcription factor activity
FRC75_13785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRC75_13810	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRC75_13825	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FRC75_13850	COG3634	alkyl hydroperoxide reductase activity
FRC75_13895	COG4774	siderophore transport
FRC75_13920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRC75_13925	COG0657	acetylesterase activity
FRC75_13935	COG4628	conserved protein (DUF2132)
FRC75_13945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FRC75_13965	COG2308	Evidence 4 Homologs of previously reported genes of
FRC75_14005	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FRC75_14010	COG0840	transmembrane signaling receptor activity
FRC75_14015	COG0840	transmembrane signaling receptor activity
FRC75_14025	COG0741	lytic transglycosylase activity
FRC75_14045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRC75_14050	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FRC75_14055	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FRC75_14070	COG2850	peptidyl-arginine hydroxylation
FRC75_14075	COG1047	Peptidyl-prolyl cis-trans
FRC75_14085	COG0756	dUTP diphosphatase activity
FRC75_14090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FRC75_14095	COG0504	CTP synthase activity
FRC75_14100	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FRC75_14120	COG0148	phosphopyruvate hydratase activity
FRC75_14125	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FRC75_14135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FRC75_14145	COG2833	Protein of unknown function (DUF455)
FRC75_14150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FRC75_14155	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FRC75_14160	COG3181	Tripartite tricarboxylate transporter family receptor
FRC75_14165	COG4974	Belongs to the 'phage' integrase family
FRC75_14195	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FRC75_14200	COG0802	atpase or kinase
FRC75_14205	COG0860	N-Acetylmuramoyl-L-alanine amidase
FRC75_14220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRC75_14225	COG0586	Pfam SNARE associated Golgi protein
FRC75_14230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FRC75_14240	COG0584	glycerophosphoryl diester phosphodiesterase
FRC75_14245	COG2267	carboxylic ester hydrolase activity
FRC75_14250	COG1733	regulation of RNA biosynthetic process
FRC75_14255	COG0702	epimerase
FRC75_14260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FRC75_14265	COG1136	(ABC) transporter
FRC75_14270	COG0071	Belongs to the small heat shock protein (HSP20) family
FRC75_14290	COG0457	Tetratricopeptide repeat
FRC75_14290	COG0463	Glycosyl transferase, family 2
FRC75_14335	COG1132	(ABC) transporter
FRC75_14350	COG1007	ATP synthesis coupled electron transport
FRC75_14365	COG0713	ATP synthesis coupled electron transport
FRC75_14375	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRC75_14380	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FRC75_14385	COG1034	ATP synthesis coupled electron transport
FRC75_14390	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FRC75_14395	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FRC75_14400	COG0649	NAD binding
FRC75_14405	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRC75_14410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRC75_14415	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRC75_14430	COG0149	triose-phosphate isomerase activity
FRC75_14435	COG0604	alcohol dehydrogenase
FRC75_14435	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_14435	COG3321	synthase
FRC75_14440	COG1185	polyribonucleotide nucleotidyltransferase activity
FRC75_14445	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FRC75_14450	COG0436	Aminotransferase
FRC75_14460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRC75_14465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRC75_14475	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FRC75_14495	COG0542	response to heat
FRC75_14500	COG0314	molybdopterin synthase activity
FRC75_14525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRC75_14530	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FRC75_14535	COG0303	'Molybdopterin
FRC75_14540	COG1763	Mo-molybdopterin cofactor biosynthetic process
FRC75_14555	COG0436	Aminotransferase
FRC75_14565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRC75_14570	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FRC75_14585	COG0359	binds to the 23S rRNA
FRC75_14590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FRC75_14600	COG0360	Binds together with S18 to 16S ribosomal RNA
FRC75_14605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRC75_14610	COG0443	Heat shock 70 kDa protein
FRC75_14615	COG0484	heat shock protein binding
FRC75_14625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FRC75_14635	COG0066	3-isopropylmalate dehydratase activity
FRC75_14640	COG0473	3-isopropylmalate dehydrogenase activity
FRC75_14650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FRC75_14660	COG0101	tRNA pseudouridine synthase activity
FRC75_14665	COG0135	phosphoribosylanthranilate isomerase activity
FRC75_14670	COG0133	tryptophan synthase activity
FRC75_14675	COG0159	tryptophan synthase activity
FRC75_14680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FRC75_14685	COG0762	integral membrane protein
FRC75_14700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FRC75_14725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FRC75_14740	COG3064	Membrane
FRC75_14745	COG1472	Belongs to the glycosyl hydrolase 3 family
FRC75_14750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FRC75_14755	COG1381	Involved in DNA repair and RecF pathway recombination
FRC75_14760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FRC75_14765	COG0571	ribonuclease III activity
FRC75_14775	COG0681	Belongs to the peptidase S26 family
FRC75_14780	COG0481	GTPase activity
FRC75_14785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRC75_14810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRC75_14815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRC75_14820	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_14825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FRC75_14830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRC75_14835	COG0416	fatty acid biosynthetic process
FRC75_14840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FRC75_14845	COG1399	metal-binding, possibly nucleic acid-binding protein
FRC75_14850	COG0424	maF-like protein
FRC75_14855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FRC75_14860	COG0616	signal peptide processing
FRC75_14860	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FRC75_14885	COG1530	ribonuclease E activity
FRC75_14890	COG3022	response to hydroperoxide
FRC75_14900	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FRC75_14900	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FRC75_14910	COG0728	peptidoglycan biosynthetic process
FRC75_14915	COG0268	Binds directly to 16S ribosomal RNA
FRC75_14920	COG0579	oxidoreductase
FRC75_14930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRC75_14935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FRC75_14960	COG0727	PFAM Uncharacterised protein family (UPF0153)
FRC75_14965	COG1522	sequence-specific DNA binding
FRC75_14970	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FRC75_14980	COG3483	tryptophan 2,3-dioxygenase activity
FRC75_15000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FRC75_15005	COG2916	Histone family protein nucleoid-structuring protein H-NS
FRC75_15010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FRC75_15015	COG0513	Belongs to the DEAD box helicase family
FRC75_15020	COG2321	neutral zinc metallopeptidase
FRC75_15035	COG0717	Belongs to the dCTP deaminase family
FRC75_15050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FRC75_15055	COG2366	antibiotic biosynthetic process
FRC75_15065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FRC75_15090	COG4603	Belongs to the binding-protein-dependent transport system permease family
FRC75_15110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FRC75_15125	COG3447	MASE1 domain protein
FRC75_15125	COG5002	protein histidine kinase activity
FRC75_15125	COG5001	Diguanylate cyclase
FRC75_15145	COG0251	oxidation-reduction process
FRC75_15190	COG0405	Gamma-glutamyltransferase
FRC75_15200	COG2186	Transcriptional regulator
FRC75_15215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRC75_15255	COG1301	dicarboxylic acid transport
FRC75_15260	COG0840	transmembrane signaling receptor activity
FRC75_15265	COG2186	Transcriptional regulator
FRC75_15270	COG1953	Uracil, thiamine, allantoin
FRC75_15290	COG0281	malic enzyme
FRC75_15290	COG0280	phosphate acetyltransferase
FRC75_15305	COG1116	anion transmembrane transporter activity
FRC75_15310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRC75_15335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FRC75_15355	COG0829	nickel cation binding
FRC75_15360	COG0840	transmembrane signaling receptor activity
FRC75_15365	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_15415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FRC75_15420	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FRC75_15430	COG0084	hydrolase, TatD family'
FRC75_15435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRC75_15440	COG0714	Associated with various cellular activities
FRC75_15460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FRC75_15480	COG0805	protein transport
FRC75_15485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRC75_15490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRC75_15495	COG0537	adenosine 5'-monophosphoramidase activity
FRC75_15510	COG0140	phosphoribosyl-ATP diphosphatase activity
FRC75_15515	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FRC75_15520	COG0107	imidazoleglycerol-phosphate synthase activity
FRC75_15530	COG1301	dicarboxylic acid transport
FRC75_15535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FRC75_15565	COG0438	transferase activity, transferring glycosyl groups
FRC75_15585	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FRC75_15595	COG0131	Imidazoleglycerol-phosphate dehydratase
FRC75_15600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FRC75_15635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FRC75_15640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FRC75_15645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRC75_15650	COG5007	Belongs to the BolA IbaG family
FRC75_15655	COG0842	Transport permease protein
FRC75_15660	COG1131	(ABC) transporter
FRC75_15680	COG2853	Lipoprotein
FRC75_15685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FRC75_15690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRC75_15695	COG1127	ABC transporter
FRC75_15700	COG1126	abc transporter atp-binding protein
FRC75_15705	COG0765	amino acid transport
FRC75_15710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRC75_15720	COG0067	glutamate synthase
FRC75_15720	COG0069	glutamate synthase activity
FRC75_15720	COG0070	glutamate synthase
FRC75_15740	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FRC75_15745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FRC75_15750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FRC75_15790	COG1965	Belongs to the frataxin family
FRC75_15820	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FRC75_15825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FRC75_15830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FRC75_15835	COG1333	cytochrome c biogenesis protein
FRC75_15845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FRC75_15855	COG1560	Kdo2-lipid A biosynthetic process
FRC75_15865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FRC75_15880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FRC75_15885	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FRC75_15885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRC75_15920	COG1953	Uracil, thiamine, allantoin
FRC75_15930	COG0493	'glutamate synthase
FRC75_15935	COG1309	transcriptional regulator
FRC75_15945	COG1216	Glycosyl transferase, family 2
FRC75_15965	COG0367	asparagine synthase
FRC75_15970	COG0438	transferase activity, transferring glycosyl groups
FRC75_15975	COG0367	asparagine synthase
FRC75_15985	COG0438	transferase activity, transferring glycosyl groups
FRC75_15990	COG2226	methyltransferase
FRC75_16025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FRC75_16040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FRC75_16045	COG0459	protein refolding
FRC75_16050	COG0166	Belongs to the GPI family
FRC75_16055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FRC75_16060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FRC75_16075	COG0840	transmembrane signaling receptor activity
FRC75_16080	COG4608	Belongs to the ABC transporter superfamily
FRC75_16085	COG0444	Belongs to the ABC transporter superfamily
FRC75_16090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRC75_16095	COG0747	negative chemotaxis
FRC75_16100	COG1473	amidohydrolase
FRC75_16120	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FRC75_16125	COG1765	OsmC-like protein
FRC75_16130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FRC75_16135	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FRC75_16155	COG4970	Tfp pilus assembly protein FimT
FRC75_16205	COG1178	ABC-type Fe3 transport system permease component
FRC75_16210	COG3842	ATPase activity
FRC75_16230	COG0540	Belongs to the ATCase OTCase family
FRC75_16235	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FRC75_16240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRC75_16245	COG1678	Uncharacterized ACR, COG1678
FRC75_16250	COG0415	Belongs to the DNA photolyase family
FRC75_16255	COG0643	Histidine kinase
FRC75_16255	COG2198	Histidine kinase
FRC75_16260	COG0840	transmembrane signaling receptor activity
FRC75_16265	COG0835	chemotaxis
FRC75_16280	COG1773	rubredoxin
FRC75_16285	COG0351	phosphomethylpyrimidine kinase
FRC75_16285	COG0352	thiamine-phosphate diphosphorylase activity
FRC75_16285	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRC75_16290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FRC75_16300	COG0138	bifunctional purine biosynthesis protein purh
FRC75_16305	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FRC75_16310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRC75_16320	COG1238	metal cluster binding
FRC75_16330	COG0517	IMP dehydrogenase activity
FRC75_16330	COG1125	glycine betaine transport
FRC75_16345	COG0012	GTP binding
FRC75_16350	COG0633	Ferredoxin
FRC75_16350	COG3217	Mosc domain protein beta barrel domain protein
FRC75_16355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRC75_16370	COG1024	Enoyl-CoA hydratase
FRC75_16375	COG3829	transcription factor binding
FRC75_16380	COG0431	NADPH-dependent FMN reductase
FRC75_16405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRC75_16410	COG2205	protein histidine kinase activity
FRC75_16420	COG2204	response regulator
FRC75_16430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FRC75_16465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRC75_16475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FRC75_16485	COG2264	protein methyltransferase activity
FRC75_16490	COG0439	Biotin carboxylase
FRC75_16495	COG0511	ligase activity, forming carbon-carbon bonds
FRC75_16500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRC75_16510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRC75_16520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FRC75_16530	COG0312	modulator of DNA gyrase
FRC75_16535	COG0154	amidase activity
FRC75_16545	COG0772	Belongs to the SEDS family
FRC75_16550	COG3150	esterase
FRC75_16560	COG0557	exoribonuclease II activity
FRC75_16570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FRC75_16575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRC75_16580	COG1414	Transcriptional regulator
FRC75_16605	COG0575	Belongs to the CDS family
FRC75_16610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FRC75_16625	COG0840	transmembrane signaling receptor activity
FRC75_16630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FRC75_16635	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FRC75_16640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FRC75_16650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FRC75_16655	COG1181	Belongs to the D-alanine--D-alanine ligase family
FRC75_16660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRC75_16665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FRC75_16670	COG0772	Belongs to the SEDS family
FRC75_16675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FRC75_16680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRC75_16685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FRC75_16690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FRC75_16700	COG3116	cell division
FRC75_16705	COG0275	rRNA processing
FRC75_16710	COG2001	Belongs to the MraZ family
FRC75_16715	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FRC75_16720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FRC75_16735	COG0523	cobalamin synthesis protein
FRC75_16740	COG5001	Diguanylate cyclase
FRC75_16740	COG3447	MASE1 domain protein
FRC75_16740	COG5002	protein histidine kinase activity
FRC75_16760	COG1649	PFAM Uncharacterised BCR, COG1649
FRC75_16765	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FRC75_16775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FRC75_16780	COG0625	glutathione transferase activity
FRC75_16815	COG4269	membrane
FRC75_16830	COG3266	domain, Protein
FRC75_16835	COG3267	Type II secretory pathway component ExeA
FRC75_16835	COG3409	Peptidoglycan-binding domain 1 protein
FRC75_16890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FRC75_16895	COG0519	Catalyzes the synthesis of GMP from XMP
FRC75_16920	COG1473	amidohydrolase
FRC75_16935	COG0243	molybdopterin cofactor binding
FRC75_16975	COG1335	isochorismatase
FRC75_16980	COG1741	Belongs to the pirin family
FRC75_16985	COG0583	DNA-binding transcription factor activity
FRC75_16995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FRC75_17000	COG0129	dihydroxy-acid dehydratase activity
FRC75_17010	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FRC75_17015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FRC75_17025	COG3706	GGDEF domain
FRC75_17040	COG1272	protein, Hemolysin III
FRC75_17085	COG0477	Major facilitator Superfamily
FRC75_17115	COG3846	protein secretion by the type IV secretion system
FRC75_17130	COG3451	type IV secretory pathway VirB4
FRC75_17140	COG3838	Conjugal transfer protein Trbc
FRC75_17145	COG4962	Type ii secretion system protein e
FRC75_17170	COG0583	DNA-binding transcription factor activity
FRC75_17195	COG0583	DNA-binding transcription factor activity
FRC75_17200	COG0656	L-ascorbic acid biosynthetic process
FRC75_17210	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRC75_17225	COG4372	Transposase
FRC75_17235	COG0583	DNA-binding transcription factor activity
FRC75_17245	COG0738	Major facilitator superfamily
FRC75_17250	COG2814	Major facilitator Superfamily
FRC75_17265	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FRC75_17295	COG4959	Type IV secretory pathway protease TraF
FRC75_17345	COG5489	Protein of unknown function (DUF736)
FRC75_17350	COG1475	DNA binding
FRC75_17370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRC75_17405	COG3945	hemerythrin HHE cation binding domain
FRC75_17420	COG0288	reversible hydration of carbon dioxide
FRC75_17425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRC75_17430	COG2181	nitrate reductase activity
FRC75_17435	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FRC75_17440	COG1140	nitrate reductase beta subunit
FRC75_17445	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FRC75_17450	COG2223	nitrite transmembrane transporter activity
FRC75_17465	COG4771	TonB-dependent receptor
FRC75_17480	COG2197	response regulator
FRC75_17495	COG1285	pathogenesis
FRC75_17515	COG0583	DNA-binding transcription factor activity
FRC75_17525	COG0277	FAD linked oxidase domain protein
FRC75_17545	COG2733	membrane
FRC75_17570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRC75_17585	COG2084	Dehydrogenase
FRC75_17590	COG2823	Periplasmic or secreted lipoprotein
FRC75_17595	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FRC75_17600	COG0792	nuclease activity
FRC75_17605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FRC75_17610	COG0443	Heat shock 70 kDa protein
FRC75_17620	COG0203	ribosomal protein L17
FRC75_17625	COG0202	RNA polymerase activity
FRC75_17630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FRC75_17635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FRC75_17640	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FRC75_17645	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FRC75_17650	COG0201	protein transport
FRC75_17655	COG0200	Binds to the 23S rRNA
FRC75_17660	COG1841	ribosomal large subunit assembly
FRC75_17665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FRC75_17670	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FRC75_17675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FRC75_17680	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FRC75_17685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FRC75_17690	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FRC75_17695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FRC75_17700	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FRC75_17720	COG0395	ABC-type sugar transport system, permease component
FRC75_17730	COG3842	ATPase activity
FRC75_17735	COG3842	ATPase activity
FRC75_17745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FRC75_17760	COG0463	Glycosyl transferase, family 2
FRC75_17775	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRC75_17780	COG0783	Belongs to the Dps family
FRC75_17790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FRC75_17830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FRC75_17835	COG0134	indole-3-glycerol-phosphate synthase activity
FRC75_17840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRC75_17845	COG1280	lysine exporter protein (LysE YggA)
FRC75_17850	COG0512	Glutamine amidotransferase of anthranilate synthase
FRC75_17870	COG2336	PFAM SpoVT AbrB
FRC75_17900	COG0251	oxidation-reduction process
FRC75_17930	COG0697	spore germination
FRC75_17950	COG2894	cell division
FRC75_17995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FRC75_18000	COG0270	DNA (cytosine-5-)-methyltransferase activity
FRC75_18195	COG0587	DNA-directed DNA polymerase activity
FRC75_18325	COG2084	Dehydrogenase
FRC75_18340	COG2003	Belongs to the UPF0758 family
FRC75_18380	COG0582	viral genome integration into host DNA
FRC75_18430	COG1196	nuclear chromosome segregation
FRC75_18430	COG0741	lytic transglycosylase activity
FRC75_18430	COG0739	heme binding
FRC75_18435	COG0500	methyltransferase
FRC75_18550	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FRC75_18555	COG4789	Type iii secretion
FRC75_18570	COG4790	Type iii secretion
FRC75_18575	COG4794	Type iii secretion
FRC75_18595	COG2207	Transcriptional regulator
FRC75_18615	COG0546	phosphoglycolate phosphatase activity
FRC75_18625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRC75_18630	COG2967	ApaG domain
FRC75_18645	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FRC75_18665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FRC75_18680	COG0659	secondary active sulfate transmembrane transporter activity
FRC75_18685	COG0653	protein targeting
FRC75_18695	COG4178	(ABC) transporter
FRC75_18715	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FRC75_18720	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FRC75_18725	COG1137	ATPase activity
FRC75_18735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRC75_18745	COG0018	arginyl-trna synthetase
FRC75_18775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FRC75_18780	COG0840	transmembrane signaling receptor activity
FRC75_18790	COG1942	4-Oxalocrotonate Tautomerase
FRC75_18795	COG2814	Major facilitator Superfamily
FRC75_18800	COG0121	glutamine amidotransferase
FRC75_18890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRC75_18895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRC75_18955	COG1201	RNA secondary structure unwinding
FRC75_18960	COG1793	dna ligase
FRC75_18965	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FRC75_18965	COG1793	dna ligase
FRC75_18970	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FRC75_18975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FRC75_18980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FRC75_18985	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FRC75_18990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRC75_18995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FRC75_19005	COG0356	it plays a direct role in the translocation of protons across the membrane
FRC75_19015	COG2921	Belongs to the UPF0250 family
FRC75_19020	COG0321	lipoyl(octanoyl) transferase activity
FRC75_19025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRC75_19040	COG0745	RESPONSE REGULATOR receiver
FRC75_19045	COG2205	protein histidine kinase activity
FRC75_19050	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FRC75_19055	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FRC75_19060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FRC75_19070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRC75_19075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRC75_19090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRC75_19100	COG0678	peroxiredoxin activity
FRC75_19105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FRC75_19110	COG0255	Belongs to the universal ribosomal protein uL29 family
FRC75_19115	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FRC75_19120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FRC75_19125	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FRC75_19130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FRC75_19135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FRC75_19140	COG0089	rRNA binding
FRC75_19145	COG0088	Forms part of the polypeptide exit tunnel
FRC75_19150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FRC75_19155	COG0051	transcription antitermination factor activity, RNA binding
FRC75_19160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRC75_19165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FRC75_19170	COG0049	tRNA binding
FRC75_19175	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRC75_19180	COG1686	Belongs to the peptidase S11 family
FRC75_19185	COG2945	thiolester hydrolase activity
FRC75_19200	COG1981	membrane
FRC75_19210	COG0598	Magnesium transport protein CorA
FRC75_19215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRC75_19215	COG0519	Catalyzes the synthesis of GMP from XMP
FRC75_19220	COG1846	Transcriptional regulator
FRC75_19230	COG1566	PFAM secretion protein HlyD family protein
FRC75_19240	COG0412	Dienelactone hydrolase
FRC75_19245	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_19250	COG2095	MarC family integral membrane protein
FRC75_19255	COG0745	RESPONSE REGULATOR receiver
FRC75_19260	COG2205	protein histidine kinase activity
FRC75_19265	COG4452	Inner membrane protein CreD
FRC75_19285	COG3237	CsbD-like
FRC75_19310	COG1127	ABC transporter
FRC75_19315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRC75_19335	COG1760	l-serine dehydratase
FRC75_19340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRC75_19345	COG0765	amino acid transport
FRC75_19360	COG0768	penicillin binding
FRC75_19365	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FRC75_19375	COG1077	Cell shape determining protein MreB Mrl
FRC75_19380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRC75_19385	COG0154	amidase activity
FRC75_19390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRC75_19400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FRC75_19405	COG0708	Exodeoxyribonuclease III
FRC75_19415	COG2814	Major facilitator Superfamily
FRC75_19420	COG0583	DNA-binding transcription factor activity
FRC75_19440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRC75_19445	COG0471	metal ion transport
FRC75_19450	COG0501	Belongs to the peptidase M48B family
FRC75_19470	COG2211	Major facilitator Superfamily
FRC75_19475	COG0745	RESPONSE REGULATOR receiver
FRC75_19490	COG0477	Major facilitator Superfamily
FRC75_19510	COG1215	transferase activity, transferring glycosyl groups
FRC75_19555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FRC75_19560	COG0625	glutathione transferase activity
FRC75_19580	COG0747	negative chemotaxis
FRC75_19590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FRC75_19595	COG0477	Major facilitator Superfamily
FRC75_19605	COG0386	Belongs to the glutathione peroxidase family
FRC75_19635	COG0247	lactate metabolic process
FRC75_19645	COG0277	FAD linked oxidase domain protein
FRC75_19690	COG0004	ammonium transporteR
FRC75_19695	COG0347	Belongs to the P(II) protein family
FRC75_19705	COG0606	chelatase, subunit chli
FRC75_19715	COG4191	Histidine kinase
FRC75_19720	COG3181	Tripartite tricarboxylate transporter family receptor
FRC75_19725	COG0840	transmembrane signaling receptor activity
FRC75_19735	COG0583	DNA-binding transcription factor activity
FRC75_19795	COG0646	methionine synthase
FRC75_19795	COG1410	methionine synthase
FRC75_19815	COG0765	amino acid transport
FRC75_19820	COG0765	amino acid transport
FRC75_19825	COG1126	abc transporter atp-binding protein
FRC75_19830	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FRC75_19875	COG0583	DNA-binding transcription factor activity
FRC75_19915	COG2326	polyphosphate kinase activity
FRC75_19925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FRC75_19965	COG3181	Tripartite tricarboxylate transporter family receptor
FRC75_19980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRC75_19995	COG0583	DNA-binding transcription factor activity
FRC75_20030	COG0840	transmembrane signaling receptor activity
FRC75_20085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRC75_20115	COG2423	ornithine cyclodeaminase activity
FRC75_20125	COG2271	Major facilitator Superfamily
FRC75_20130	COG0625	glutathione transferase activity
FRC75_20150	COG1960	acyl-CoA dehydrogenase activity
FRC75_20160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FRC75_20165	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FRC75_20170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FRC75_20175	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FRC75_20210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRC75_20215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FRC75_20230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRC75_20235	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FRC75_20240	COG2894	cell division
FRC75_20245	COG0850	regulation of cytokinetic process
FRC75_20250	COG1183	phosphatidylcholine synthase activity
FRC75_20260	COG2423	ornithine cyclodeaminase activity
FRC75_20270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRC75_20280	COG0501	Belongs to the peptidase M48B family
FRC75_20285	COG1414	Transcriptional regulator
FRC75_20305	COG0395	ABC-type sugar transport system, permease component
FRC75_20310	COG1116	anion transmembrane transporter activity
FRC75_20340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FRC75_20360	COG2233	PERMEase
FRC75_20375	COG2050	protein possibly involved in aromatic compounds catabolism
FRC75_20380	COG2096	Adenosyltransferase
FRC75_20395	COG0277	FAD linked oxidase domain protein
FRC75_20490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRC75_20505	COG3411	Ferredoxin
FRC75_20540	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FRC75_20560	COG2272	Belongs to the type-B carboxylesterase lipase family
FRC75_20575	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRC75_20575	COG0546	phosphoglycolate phosphatase activity
FRC75_20580	COG0277	FAD linked oxidase domain protein
FRC75_20600	COG0493	'glutamate synthase
FRC75_20625	COG1192	Involved in chromosome partitioning
FRC75_20630	COG1280	lysine exporter protein (LysE YggA)
FRC75_20635	COG0357	Ribosomal RNA small subunit methyltransferase G
FRC75_20640	COG0445	tRNA wobble uridine modification
FRC75_20660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRC75_20665	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FRC75_20685	COG0642	Histidine kinase
FRC75_20690	COG0745	RESPONSE REGULATOR receiver
FRC75_20725	COG2217	Heavy metal translocating P-type atpase
FRC75_20735	COG0789	Transcriptional regulator
FRC75_20740	COG0183	Belongs to the thiolase family
FRC75_20765	COG2715	membrane protein required for spore maturation
FRC75_20770	COG2974	May be involved in recombination
FRC75_20790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FRC75_20795	COG0791	NLP P60 protein
FRC75_20800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRC75_20815	COG2176	DNA-directed DNA polymerase activity
FRC75_20830	COG1199	ATP-dependent helicase activity
FRC75_20850	COG1764	response to oxidative stress
FRC75_20890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FRC75_20895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FRC75_20900	COG0594	ribonuclease P activity
FRC75_20905	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FRC75_20910	COG0706	membrane insertase activity
FRC75_20920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FRC75_20940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FRC75_20955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FRC75_20965	COG0300	oxidoreductase activity
FRC75_20970	COG0724	RNA recognition motif
FRC75_20975	COG0724	RNA recognition motif
FRC75_20980	COG2119	membrane
FRC75_20985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRC75_20990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRC75_21000	COG4302	ethanolamine ammonia-lyase activity
FRC75_21005	COG4303	Ethanolamine ammonia lyase large subunit
FRC75_21010	COG1113	amino acid transport
FRC75_21015	COG2207	Transcriptional regulator
FRC75_21025	COG2814	Major facilitator Superfamily
FRC75_21030	COG1196	nuclear chromosome segregation
FRC75_21045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRC75_21055	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FRC75_21060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRC75_21065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRC75_21080	COG0281	malic enzyme
FRC75_21080	COG0280	phosphate acetyltransferase
FRC75_21130	COG1802	Transcriptional regulator
FRC75_21195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FRC75_21200	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FRC75_21225	COG0307	riboflavin synthase, alpha
FRC75_21255	COG0494	nUDIX hydrolase
FRC75_21260	COG0482	sulfurtransferase activity
FRC75_21265	COG1620	l-lactate permease
FRC75_21295	COG0640	Transcriptional regulator
FRC75_21320	COG0629	single-stranded DNA binding
FRC75_21330	COG2814	Major facilitator Superfamily
FRC75_21370	COG0840	transmembrane signaling receptor activity
FRC75_21400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FRC75_21405	COG0284	orotidine-5'-phosphate decarboxylase activity
FRC75_21410	COG0697	spore germination
FRC75_21420	COG0126	phosphoglycerate kinase activity
FRC75_21435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FRC75_21445	COG0242	peptide deformylase activity
FRC75_21455	COG0758	DNA mediated transformation
FRC75_21460	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FRC75_21465	COG0045	succinate-CoA ligase (ADP-forming) activity
FRC75_21470	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FRC75_21475	COG0861	Integral membrane protein TerC family
FRC75_21480	COG0631	protein serine/threonine phosphatase activity
FRC75_21485	COG1716	ATPase activity
FRC75_21495	COG3307	-O-antigen
FRC75_21500	COG0315	cyclic pyranopterin monophosphate synthase activity
FRC75_21505	COG4783	chaperone-mediated protein folding
FRC75_21510	COG1950	PFAM Membrane protein of
FRC75_21520	COG0861	Integral membrane protein TerC family
FRC75_21545	COG0625	glutathione transferase activity
FRC75_21570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRC75_21580	COG1309	transcriptional regulator
FRC75_21595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRC75_21600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FRC75_21630	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FRC75_21650	COG2814	Major facilitator Superfamily
FRC75_21660	COG1522	sequence-specific DNA binding
FRC75_21670	COG1862	Preprotein translocase
FRC75_21675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRC75_21680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRC75_21690	COG2137	regulation of response to DNA damage stimulus
FRC75_21695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FRC75_21710	COG0642	Histidine kinase
FRC75_21720	COG0583	DNA-binding transcription factor activity
FRC75_21750	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FRC75_21750	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FRC75_21795	COG1714	RDD family
FRC75_21850	COG2764	glyoxalase bleomycin resistance protein dioxygenase
FRC75_21865	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_21870	COG2194	sulfuric ester hydrolase activity
FRC75_21880	COG0668	transmembrane transport
FRC75_21940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FRC75_21975	COG0583	DNA-binding transcription factor activity
FRC75_21985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FRC75_22005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FRC75_22015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FRC75_22020	COG0006	proline dipeptidase activity
FRC75_22025	COG0469	pyruvate kinase activity
FRC75_22060	COG0318	PFAM AMP-dependent synthetase and ligase
FRC75_22070	COG0598	Magnesium transport protein CorA
FRC75_22085	COG1214	PFAM Peptidase M22, glycoprotease
FRC75_22110	COG0009	L-threonylcarbamoyladenylate synthase
FRC75_22115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FRC75_22120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FRC75_22125	COG3118	belongs to the thioredoxin family
FRC75_22135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FRC75_22140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FRC75_22150	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FRC75_22155	COG0735	belongs to the Fur family
FRC75_22160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRC75_22165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FRC75_22180	COG5001	Diguanylate cyclase
FRC75_22180	COG3300	MHYT domain
FRC75_22190	COG0495	leucyl-tRNA aminoacylation
FRC75_22210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FRC75_22215	COG0569	domain protein
FRC75_22220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FRC75_22230	COG3158	transport of potassium into the cell
FRC75_22235	COG3135	benzoate transporter
FRC75_22240	COG0189	ligase activity
FRC75_22285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRC75_22295	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FRC75_22305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FRC75_22310	COG0081	regulation of translation
FRC75_22315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FRC75_22320	COG0222	ribosome binding
FRC75_22325	COG0085	RNA polymerase activity
FRC75_22330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FRC75_22340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FRC75_22340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FRC75_22350	COG5000	phosphorelay sensor kinase activity
FRC75_22355	COG2204	response regulator
FRC75_22370	COG2032	superoxide dismutase activity
FRC75_22385	COG3550	peptidyl-serine autophosphorylation
FRC75_22395	COG3046	protein related to deoxyribodipyrimidine photolyase
FRC75_22410	COG1116	anion transmembrane transporter activity
FRC75_22415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRC75_22425	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_22430	COG2365	Tyrosine phosphatase family
FRC75_22450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRC75_22460	COG2072	flavoprotein involved in K transport
FRC75_22470	COG3181	Tripartite tricarboxylate transporter family receptor
FRC75_22510	COG0840	transmembrane signaling receptor activity
FRC75_22520	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FRC75_22525	COG1522	sequence-specific DNA binding
FRC75_22555	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_22585	COG0343	queuine tRNA-ribosyltransferase activity
FRC75_22610	COG0210	DNA helicase
FRC75_22630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FRC75_22640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FRC75_22655	COG3119	arylsulfatase activity
FRC75_22675	COG0583	DNA-binding transcription factor activity
FRC75_22680	COG0861	Integral membrane protein TerC family
FRC75_22710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FRC75_22755	COG0840	transmembrane signaling receptor activity
FRC75_22790	COG0384	phenazine biosynthesis protein PhzF
FRC75_22795	COG0625	glutathione transferase activity
FRC75_22800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRC75_22805	COG0697	spore germination
FRC75_22815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRC75_22830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FRC75_22840	COG1705	Flagellar rod assembly protein muramidase FlgJ
FRC75_22840	COG3951	Flagellar rod assembly protein muramidase FlgJ
FRC75_22845	COG1706	bacterial-type flagellum-dependent cell motility
FRC75_22855	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FRC75_22865	COG4787	bacterial-type flagellum-dependent cell motility
FRC75_22875	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FRC75_22880	COG1558	bacterial-type flagellum-dependent cell motility
FRC75_22885	COG1815	bacterial-type flagellum-dependent cell motility
FRC75_22925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FRC75_22930	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FRC75_22935	COG0745	RESPONSE REGULATOR receiver
FRC75_22940	COG1360	Flagellar Motor Protein
FRC75_22945	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FRC75_22950	COG0438	transferase activity, transferring glycosyl groups
FRC75_22950	COG1216	Glycosyl transferase, family 2
FRC75_22955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FRC75_22960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRC75_22970	COG4106	trans-aconitate 2-methyltransferase activity
FRC75_23005	COG1677	Flagellar hook-basal body complex protein FliE
FRC75_23010	COG1766	The M ring may be actively involved in energy transduction
FRC75_23040	COG1580	Controls the rotational direction of flagella during chemotaxis
FRC75_23050	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FRC75_23065	COG1987	bacterial-type flagellum assembly
FRC75_23075	COG2197	response regulator
FRC75_23080	COG3851	Histidine kinase
FRC75_23090	COG0745	RESPONSE REGULATOR receiver
FRC75_23095	COG2198	Histidine kinase
FRC75_23095	COG0643	Histidine kinase
FRC75_23100	COG0835	chemotaxis
FRC75_23105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FRC75_23110	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FRC75_23115	COG2201	protein-glutamate methylesterase activity
FRC75_23120	COG0488	(ABC) transporter
FRC75_23150	COG0789	Transcriptional regulator
FRC75_23155	COG1960	acyl-CoA dehydrogenase activity
FRC75_23160	COG0288	reversible hydration of carbon dioxide
FRC75_23165	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FRC75_23170	COG0183	Belongs to the thiolase family
FRC75_23185	COG1960	acyl-CoA dehydrogenase activity
FRC75_23200	COG3012	SEC-C Motif Domain Protein
FRC75_23205	COG0784	Response regulator, receiver
FRC75_23205	COG2198	Histidine kinase
FRC75_23205	COG2205	protein histidine kinase activity
FRC75_23210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRC75_23235	COG0318	PFAM AMP-dependent synthetase and ligase
FRC75_23240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRC75_23245	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FRC75_23260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FRC75_23295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FRC75_23310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FRC75_23360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FRC75_23390	COG0577	efflux transmembrane transporter activity
FRC75_23390	COG1136	(ABC) transporter
FRC75_23405	COG0745	RESPONSE REGULATOR receiver
FRC75_23410	COG2205	protein histidine kinase activity
FRC75_23415	COG0418	dihydroorotase activity
FRC75_23430	COG0501	Belongs to the peptidase M48B family
FRC75_23435	COG0583	DNA-binding transcription factor activity
FRC75_23440	COG1024	Enoyl-CoA hydratase
FRC75_23440	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRC75_23445	COG1960	acyl-CoA dehydrogenase activity
FRC75_23450	COG1960	acyl-CoA dehydrogenase activity
FRC75_23455	COG1024	Enoyl-CoA hydratase
FRC75_23460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRC75_23495	COG0840	transmembrane signaling receptor activity
FRC75_23505	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FRC75_23510	COG0392	lysyltransferase activity
FRC75_23515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRC75_23520	COG3568	Endonuclease Exonuclease Phosphatase
FRC75_23540	COG0840	transmembrane signaling receptor activity
FRC75_23570	COG0326	Molecular chaperone. Has ATPase activity
FRC75_23605	COG3209	COG3209 Rhs family protein
FRC75_23650	COG2815	serine threonine protein kinase
FRC75_23650	COG0515	serine threonine protein kinase
FRC75_23660	COG1764	response to oxidative stress
FRC75_23665	COG1846	Transcriptional regulator
FRC75_23675	COG3971	2-oxopent-4-enoate hydratase activity
FRC75_23680	COG0179	Fumarylacetoacetate (FAA) hydrolase
FRC75_23705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRC75_23715	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRC75_23720	COG0842	Transport permease protein
FRC75_23725	COG1131	(ABC) transporter
FRC75_23730	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FRC75_23740	COG0443	Heat shock 70 kDa protein
FRC75_23760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRC75_23760	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRC75_23770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRC75_23770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRC75_23785	COG3706	GGDEF domain
FRC75_23790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FRC75_23795	COG0513	Belongs to the DEAD box helicase family
FRC75_23800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FRC75_23805	COG1490	D-aminoacyl-tRNA deacylase activity
FRC75_23810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FRC75_23815	COG1702	phosphate starvation-inducible protein PhoH
FRC75_23820	COG0632	four-way junction helicase activity
FRC75_23835	COG2255	four-way junction helicase activity
FRC75_23870	COG0037	tRNA processing
FRC75_23880	COG2197	response regulator
FRC75_23885	COG1966	Carbon starvation protein
FRC75_23890	COG2879	small protein
FRC75_23900	COG1028	Short-chain dehydrogenase reductase Sdr
FRC75_23915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRC75_23920	COG0076	glutamate decarboxylase activity
FRC75_23935	COG0456	acetyltransferase
FRC75_23975	COG3387	PFAM Glycoside hydrolase 15-related
FRC75_23995	COG0617	tRNA 3'-terminal CCA addition
FRC75_24015	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FRC75_24020	COG0741	lytic transglycosylase activity
FRC75_24020	COG0739	heme binding
FRC75_24020	COG1196	nuclear chromosome segregation
FRC75_24035	COG1869	D-ribose catabolic process
FRC75_24040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FRC75_24050	COG1172	Belongs to the binding-protein-dependent transport system permease family
FRC75_24055	COG1129	ABC transporter
FRC75_24065	COG0318	PFAM AMP-dependent synthetase and ligase
FRC75_24075	COG3186	Phenylalanine-4-hydroxylase
FRC75_24095	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FRC75_24100	COG1522	sequence-specific DNA binding
FRC75_24115	COG4535	Mg2 and Co2 transporter CorC
FRC75_24120	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FRC75_24135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FRC75_24145	COG3258	Cytochrome c
FRC75_24150	COG0752	glycyl-tRNA synthetase alpha subunit
FRC75_24155	COG0751	glycine-tRNA ligase activity
FRC75_24165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FRC75_24170	COG0204	Acyl-transferase
FRC75_24190	COG1652	LysM domain
FRC75_24195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FRC75_24235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FRC75_24240	COG1459	type II secretion system
FRC75_24245	COG2165	general secretion pathway protein
FRC75_24250	COG4970	Tfp pilus assembly protein FimT
FRC75_24255	COG2165	general secretion pathway protein
FRC75_24285	COG1450	Type ii and iii secretion system protein
FRC75_24300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRC75_24340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FRC75_24345	COG0745	RESPONSE REGULATOR receiver
FRC75_24355	COG1309	transcriptional regulator
FRC75_24510	COG1192	Involved in chromosome partitioning