locus-tag class description EAG14_00060 ENOG4105D9P serine threonine protein kinase EAG14_00085 ENOG4105KHS type IV fimbrial pilin protein EAG14_00090 ENOG4105KHS type IV fimbrial pilin protein EAG14_00095 ENOG4105YWY EAG14_00105 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EAG14_00115 ENOG41086DT Membrane protein of unknown function EAG14_00125 ENOG4108ZCF integral membrane protein EAG14_00130 ENOG4108ZCF integral membrane protein EAG14_00145 ENOG4108VWS Yaeq family EAG14_00150 ENOG4107QTF adenylosuccinate lyase EAG14_00155 ENOG4108U78 Glutathione S-transferase EAG14_00160 ENOG4108W9H Tetr family transcriptional regulator EAG14_00165 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter EAG14_00170 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EAG14_00175 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EAG14_00180 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EAG14_00190 ENOG4108IXY short-chain dehydrogenase reductase EAG14_00210 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EAG14_00255 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_00275 ENOG4105BZU Histidine kinase EAG14_00285 ENOG4105UYK outer membrane protein a EAG14_00320 ENOG4107SFI Major Facilitator superfamily EAG14_00325 ENOG4108YXU transcriptional regulator AsnC family EAG14_00335 ENOG4105VIE preprotein translocase, subunit YajC EAG14_00340 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EAG14_00345 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EAG14_00355 ENOG4105C79 DNA protecting protein DprA EAG14_00365 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EAG14_00375 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EAG14_00390 ENOG4105BZA Phosphoglycerate kinase EAG14_00400 ENOG4105SKN orotidine 5''-phosphate decarboxylase EAG14_00405 ENOG4105EQ2 LysR family Transcriptional regulator EAG14_00430 ENOG4105C0A alcohol dehydrogenase EAG14_00435 ENOG4105C26 Dehydrogenase EAG14_00440 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EAG14_00445 ENOG4105E0F Histidine kinase EAG14_00450 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EAG14_00470 ENOG4108WFR AraC Family Transcriptional Regulator EAG14_00480 ENOG4107RDB Major Facilitator EAG14_00490 ENOG4105DEG Vwa containing coxe family protein EAG14_00500 ENOG4108KDT Molybdate metabolism regulator EAG14_00515 ENOG4105KKX ATPase associated with various cellular activities aaa_5 EAG14_00525 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EAG14_00530 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_00540 ENOG4107EFR Flavocytochrome c EAG14_00545 ENOG41079YP Citrate utilization protein b EAG14_00565 ENOG4105ETT transcriptional Regulator, LysR family EAG14_00585 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) EAG14_00600 ENOG4105XPQ lipid carrier protein EAG14_00605 ENOG4106RZ4 Peptidase U32 EAG14_00610 ENOG4105CFP Peptidase U32 EAG14_00615 ENOG4105E5G Alpha beta hydrolase fold EAG14_00625 ENOG4105BZU Histidine kinase EAG14_00630 ENOG4108X0B nad(p)h dehydrogenase (quinone) EAG14_00635 ENOG4105DWV Homoserine O-trans-acetylase EAG14_00640 ENOG4105DWV Homoserine O-trans-acetylase EAG14_00650 ENOG4105VFU Rna-binding protein EAG14_00655 ENOG4105VFU Rna-binding protein EAG14_00670 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase EAG14_00675 ENOG4105C2X Arabinose 5-phosphate isomerase EAG14_00685 ENOG4105BZU Histidine kinase EAG14_00690 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EAG14_00695 ENOG4108IJ7 Glycine betaine EAG14_00700 ENOG4108HQS Glycine betaine EAG14_00705 ENOG4105GIJ Glycine betaine EAG14_00730 ENOG4105E0K tonB-dependent siderophore receptor EAG14_00740 ENOG4105BZU Histidine kinase EAG14_00745 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EAG14_00780 ENOG4105EXG Transcriptional regulator EAG14_00790 ENOG410642W LysR family Transcriptional regulator EAG14_00795 ENOG4107S5I aldo keto reductase EAG14_00835 ENOG4105C9U ATP-dependent DNA helicase RecQ EAG14_00855 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase EAG14_00860 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_00890 ENOG41081YN resistaNce protein EAG14_00895 ENOG4105EUP HipA domain protein EAG14_00915 ENOG4105JQN Transcriptional regulator EAG14_00920 ENOG4105EYH Exonuclease EAG14_00925 ENOG4107RH8 nuclease SbcCD subunit D EAG14_00940 ENOG4105FR1 rard protein EAG14_00945 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EAG14_00950 ENOG4108MEJ flavin reductase domain protein EAG14_00965 ENOG4106IUH DTW domain containing protein EAG14_00985 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_00995 ENOG4105HEI LysR family (Transcriptional regulator EAG14_01000 ENOG4105E1F short-chain dehydrogenase reductase EAG14_01015 ENOG4105D29 Helix-turn-helix type 11 domain protein EAG14_01045 ENOG4105EUB pirin domain protein EAG14_01065 ENOG4105EXG Transcriptional regulator EAG14_01110 ENOG4108Z86 Glutamine amidotransferase EAG14_01125 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EAG14_01145 ENOG4108ZGY Transcriptional regulator (AsnC family) EAG14_01150 ENOG4108UMR transcriptional regulator AsnC family EAG14_01155 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E EAG14_01195 ENOG4105C0Z ABC transporter EAG14_01200 ENOG4108IV0 ABC, transporter EAG14_01215 ENOG4105DND Transcriptional regulator EAG14_01225 ENOG4105D2S major facilitator superfamily EAG14_01230 ENOG4105KHM amidohydrolase 2 EAG14_01250 ENOG4105GAK amidohydrolase 2 EAG14_01270 ENOG41061H0 Monooxygenase EAG14_01280 ENOG4105CPC Aldo Keto reductase EAG14_01285 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EAG14_01290 ENOG4105CV1 Transketolase (EC 2.2.1.1) EAG14_01295 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) EAG14_01300 ENOG4108S0S Nucleotidyl transferase EAG14_01310 ENOG4107RAQ aminopeptidase EAG14_01315 ENOG4105CA9 Pyruvate kinase EAG14_01320 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EAG14_01330 ENOG4105XJC Two component transcriptional regulator (Winged helix family EAG14_01335 ENOG4105DHQ Histidine kinase EAG14_01340 ENOG4105D2N Aldolase EAG14_01345 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EAG14_01360 ENOG4105W8H transhydrogenase (subunit alpha EAG14_01365 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EAG14_01370 ENOG4105CEY Amp-dependent synthetase and ligase EAG14_01375 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EAG14_01380 ENOG4107QUT magnesium and cobalt transport protein CorA EAG14_01395 ENOG41072GX Peptidase M22 Glycoprotease EAG14_01400 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_01410 ENOG4105W3H MtN3 and saliva related transmembrane protein EAG14_01435 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EAG14_01440 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EAG14_01445 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EAG14_01450 ENOG4105K63 Thioredoxin EAG14_01455 ENOG4105C8V SAICAR synthetase EAG14_01460 ENOG4105JHE Major Facilitator Superfamily EAG14_01465 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA EAG14_01470 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN EAG14_01475 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) EAG14_01480 ENOG41090R7 Ferric uptake EAG14_01485 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EAG14_01490 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EAG14_01500 ENOG4105SG9 biopolymer transport protein, ExbD EAG14_01505 ENOG4105C8T Leucyl-tRNA synthetase EAG14_01555 ENOG4105KME endoribonuclease L-psp EAG14_01560 ENOG4108RVA ribokinase EAG14_01570 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_01590 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EAG14_01595 ENOG4105C1A potassium transporter peripheral membrane EAG14_01600 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) EAG14_01610 ENOG4105DFH Transport of potassium into the cell (By similarity) EAG14_01615 ENOG4105DKK Benzoate EAG14_01620 ENOG4105D7Z glutathione synthase EAG14_01650 ENOG4105E7A Glutamine amidotransferase EAG14_01660 ENOG41084KP 4-oxalocrotonate tautomerase EAG14_01675 ENOG4107QP3 malate synthase g EAG14_01700 ENOG4105CK2 sodium dicarboxylate symporter EAG14_01715 ENOG4105C75 arginyL-tRNA synthetase EAG14_01735 ENOG4108IUZ ABC transporter EAG14_01755 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EAG14_01770 ENOG4105CBC glutamate synthase EAG14_01780 ENOG4105CHH sulfate transporter EAG14_01810 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EAG14_01820 ENOG4108ZAI phosphatidylglycerophosphatase a EAG14_01840 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EAG14_01845 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EAG14_01850 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) EAG14_01865 ENOG4105NWN ApaG protein EAG14_01870 ENOG4105DJV ribulose-phosphate 3-epimerase EAG14_01900 ENOG4105CHR reductase EAG14_01905 ENOG4105ETT transcriptional Regulator, LysR family EAG14_01910 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EAG14_01930 ENOG4105DDQ anthranilate synthase EAG14_01935 ENOG410829K Lysine exporter protein (Lyse ygga) EAG14_01940 ENOG4107QYG anthranilate phosphoribosyltransferase EAG14_01950 ENOG4105DK0 Indole-3-glycerol phosphate synthase EAG14_01955 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EAG14_01960 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 EAG14_01995 ENOG4105C5Q Transcriptional regulator EAG14_02000 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EAG14_02010 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) EAG14_02040 ENOG4105II7 pyrroline-5-carboxylate reductase EAG14_02050 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EAG14_02060 ENOG4105E98 transcriptional regulator DeoR family EAG14_02065 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EAG14_02080 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component EAG14_02095 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EAG14_02100 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) EAG14_02105 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EAG14_02110 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EAG14_02115 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EAG14_02120 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EAG14_02125 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EAG14_02130 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EAG14_02135 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EAG14_02140 ENOG4105VPB 50S ribosomal protein L30 EAG14_02145 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EAG14_02150 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EAG14_02155 ENOG41067V7 50S ribosomal protein L36 EAG14_02160 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EAG14_02165 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EAG14_02170 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EAG14_02175 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EAG14_02180 ENOG4108ZT0 50S ribosomal protein l17 EAG14_02190 ENOG41063Z6 transcriptional regulator, lysR family EAG14_02195 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family EAG14_02225 ENOG41080T7 secreted protein EAG14_02280 ENOG4105CEY Amp-dependent synthetase and ligase EAG14_02295 ENOG4105K6H D-cysteine desulfhydrase EAG14_02300 ENOG4105EW9 transcriptional regulator AsnC family EAG14_02305 ENOG4108594 Permease of the drug metabolite transporter EAG14_02360 ENOG4105JSC dimethylmenaquinone methyltransferase EAG14_02385 ENOG4105ECP epimerase EAG14_02395 ENOG4105BZU Histidine kinase EAG14_02400 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) EAG14_02415 ENOG4105HDD phospholipase EAG14_02425 ENOG4105C4R Atp-dependent dna helicase EAG14_02460 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EAG14_02470 ENOG4105DYC esterase EAG14_02485 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EAG14_02490 ENOG4107SFI Major Facilitator superfamily EAG14_02495 ENOG41063Z6 transcriptional regulator, lysR family EAG14_02500 ENOG4105DU1 integral membrane protein, terc EAG14_02510 ENOG4105K4P CoA-binding domain protein EAG14_02535 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EAG14_02570 ENOG4107RCH Diaminopropionate ammonia-lyase EAG14_02585 ENOG4105JAB phenazine biosynthesis protein, phzf family EAG14_02590 ENOG4105JAB phenazine biosynthesis protein, phzf family EAG14_02595 ENOG4108TGY Glutathione S-transferase EAG14_02600 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EAG14_02650 ENOG4105BZU Histidine kinase EAG14_02655 ENOG4108ZXC Two component transcriptional regulator, luxr family EAG14_02660 ENOG4108ZXC Two component transcriptional regulator, luxr family EAG14_02665 ENOG4108RYK Nad-dependent epimerase dehydratase EAG14_02670 ENOG4105CR8 Transcriptional regulator EAG14_02690 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EAG14_02695 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) EAG14_02705 ENOG4105CGA flagellar basal-body rod protein FlgG EAG14_02710 ENOG4108KPB Flagellar basal-body rod protein FlgF EAG14_02720 ENOG4105W00 Flagellar hook capping protein EAG14_02725 ENOG4108ZC9 flagellar basal-body rod protein flgc EAG14_02730 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EAG14_02735 ENOG4105CKS Flagella basal body P-ring formation protein flgA EAG14_02750 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EAG14_02760 ENOG4105FZW flagellar biosynthesis regulator FlhF EAG14_02765 ENOG4105D7B Flagellar biosynthesis protein flha EAG14_02770 ENOG4105D00 flagellar biosynthetic protein flhB EAG14_02775 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) EAG14_02780 ENOG4108VYJ response regulator receiver protein EAG14_02785 ENOG4105ER2 Ompa motb domain protein EAG14_02790 ENOG4107RD7 Flagellar Motor Protein, MotA EAG14_02815 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EAG14_02830 ENOG4105I03 Flagellin EAG14_02840 ENOG4105DTS flagellar hook-associated EAG14_02855 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EAG14_02865 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EAG14_02875 ENOG4108JIR Flagellum-specific ATP synthase EAG14_02890 ENOG4107ZI8 flagellar basal body-associated protein flil EAG14_02895 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EAG14_02910 ENOG4105CN7 Flagellar biosynthetic protein FliP EAG14_02915 ENOG4105VS8 Flagellar biosynthetic protein fliq EAG14_02920 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EAG14_02925 ENOG4105WH1 Two component transcriptional regulator luxr family EAG14_02940 ENOG4107YTP response regulator receiver protein EAG14_02950 ENOG4108V3W Chemotaxis protein, CheW EAG14_02955 ENOG4105BZU Histidine kinase EAG14_02960 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) EAG14_02965 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EAG14_02970 ENOG4105C5H ABC transporter EAG14_03010 ENOG4105C1G acyl-Coa dehydrogenase EAG14_03020 ENOG41077A9 carbonic anhydrase EAG14_03025 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) EAG14_03030 ENOG4105CHU acetyl-coa acetyltransferase EAG14_03045 ENOG4108W6C Dehydrogenase EAG14_03050 ENOG4105C1G acyl-Coa dehydrogenase EAG14_03065 ENOG4105K5B UPF0225 protein EAG14_03080 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 EAG14_03105 ENOG4105CEY Amp-dependent synthetase and ligase EAG14_03110 ENOG4107QX3 carboxylase EAG14_03120 ENOG4105C5Z peptidase EAG14_03130 ENOG41060WC Enoyl-CoA hydratase EAG14_03145 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase EAG14_03160 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EAG14_03165 ENOG4108M0I Transcriptional regulator EAG14_03200 ENOG4108Z9W Outer membrane porin EAG14_03205 ENOG4107QN1 sodium solute EAG14_03220 ENOG4105CP9 extracellular ligand-binding receptor EAG14_03225 ENOG4105CP9 extracellular ligand-binding receptor EAG14_03230 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EAG14_03255 ENOG4107QWB Ornithine cyclodeaminase EAG14_03270 ENOG4105JN3 extra-cytoplasmic solute receptor family protein EAG14_03285 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator EAG14_03290 ENOG4105CNN ABC, transporter EAG14_03295 ENOG4105C2J ABC transporter EAG14_03300 ENOG4105NWF RbsD or FucU transport EAG14_03340 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) EAG14_03345 ENOG4105DX0 Hemolysin A EAG14_03350 ENOG4105SYT Methylenetetrahydrofolate reductase EAG14_03360 ENOG4105D6S protein involved in catabolism of external DNA EAG14_03365 ENOG4106PBJ Serine threonine-protein kinase Pkn6 EAG14_03370 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EAG14_03375 ENOG4108UJD 30S ribosomal protein S9 EAG14_03390 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EAG14_03395 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) EAG14_03400 ENOG4105DR5 peptidase EAG14_03405 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EAG14_03410 ENOG4105BZU Histidine kinase EAG14_03415 ENOG4105ETT transcriptional Regulator, LysR family EAG14_03425 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EAG14_03430 ENOG4105BZU Histidine kinase EAG14_03435 ENOG4105F7P transcriptional regulator AsnC family EAG14_03440 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EAG14_03445 ENOG4108Z9W Outer membrane porin EAG14_03455 ENOG41073TP transcriptional regulator EAG14_03460 ENOG4105CXK mandelate racemase muconate lactonizing EAG14_03470 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EAG14_03475 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EAG14_03485 ENOG4108JQ7 (ABC) transporter EAG14_03495 ENOG4105VG1 fes assembly suf system protein EAG14_03515 ENOG4105GAK amidohydrolase 2 EAG14_03525 ENOG4105JSC dimethylmenaquinone methyltransferase EAG14_03530 ENOG4108JQ1 Dehydrogenase EAG14_03565 ENOG4108UMI ABC transporter, permease EAG14_03575 ENOG4105D01 (LipO)protein EAG14_03580 ENOG4105D01 (LipO)protein EAG14_03590 ENOG4105FDT acyl-CoA dehydrogenase EAG14_03610 ENOG4105XQ6 frataxin-like protein EAG14_03615 ENOG4108JQC penicillin-binding protein 1A EAG14_03640 ENOG4105E4G Type IV pilus EAG14_03645 ENOG4105D49 3-dehydroquinate synthase EAG14_03680 ENOG4106TNF Periplasmic binding protein EAG14_03685 ENOG4105E5Q amino acid AbC transporter EAG14_03695 ENOG4105DHJ ABC, transporter EAG14_03700 ENOG4105CY3 ABC transporter, permease EAG14_03705 ENOG4107PE3 Mammalian cell entry related domain protein EAG14_03725 ENOG4105DA5 (ABC) transporter EAG14_03730 ENOG4105E3A (ABC) transporter EAG14_03735 ENOG4105VFK BolA family EAG14_03740 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EAG14_03745 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EAG14_03760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EAG14_03770 ENOG4105CXK mandelate racemase muconate lactonizing EAG14_03775 ENOG4108RTU Aldolase EAG14_03780 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 EAG14_03795 ENOG41062B0 ABC transporter, permease EAG14_03800 ENOG4107R9N ABC transporter EAG14_03805 ENOG4105C2J ABC transporter EAG14_03810 ENOG4107RNG ABC transporter EAG14_03820 ENOG4105DFW ABC transporter EAG14_03825 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator EAG14_03830 ENOG4105C26 Dehydrogenase EAG14_03840 ENOG4105FGE Short-chain dehydrogenase reductase Sdr EAG14_03845 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein EAG14_03850 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EAG14_03855 ENOG4105E3W Two component transcriptional regulator (Winged helix family EAG14_03860 ENOG4105EB3 Histidine kinase EAG14_03865 ENOG4105C1P efflux transporter, rnd family, mfp subunit EAG14_03870 ENOG4105BZS acriflavin resistance protein EAG14_03875 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EAG14_03880 ENOG4105CTX dehydratase EAG14_03885 ENOG4105ETE Transcriptional regulator (LacI family EAG14_03895 ENOG4105EQX glucarate dehydratase EAG14_03905 ENOG4107YNJ LysR family Transcriptional regulator EAG14_03910 ENOG4105CMJ mandelate racemase muconate lactonizing EAG14_03920 ENOG410814C multidrug resistance protein EAG14_03970 ENOG4105CPU Monooxygenase EAG14_03980 ENOG4105E2B Taurine dioxygenase EAG14_03990 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EAG14_03995 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EAG14_04010 ENOG41061MV Arylsulfatase EAG14_04015 ENOG4107R11 Transcriptional regulator EAG14_04030 ENOG4108T2C cysteine dioxygenase type I EAG14_04065 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EAG14_04070 ENOG4105GVF (ABC) transporter EAG14_04105 ENOG4105EQ0 Major Facilitator superfamily EAG14_04125 ENOG4105FDT acyl-CoA dehydrogenase EAG14_04130 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase EAG14_04135 ENOG4105GVF (ABC) transporter EAG14_04145 ENOG4105DMF Dehydrogenase EAG14_04155 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EAG14_04165 ENOG4106FTQ Taurine ABC transporter, periplasmic EAG14_04170 ENOG4105E2B Taurine dioxygenase EAG14_04180 ENOG4105D7W serine acetyltransferase EAG14_04190 ENOG4105ESN nucleotide-binding protein EAG14_04195 ENOG4105C9B Cysteine desulfurase EAG14_04200 ENOG4105D6J arsenicaL-resistance protein EAG14_04225 ENOG4105BZU Histidine kinase EAG14_04240 ENOG4108Z33 Thiol disulfide Interchange Protein EAG14_04245 ENOG4108RH0 Crea protein EAG14_04250 ENOG4105D9M gamma-glutamylcysteine synthetase EAG14_04255 ENOG4107RRY Cyanophycin synthetase EAG14_04260 ENOG4105BZ1 (ABC) transporter EAG14_04285 ENOG4105D7Q type ii secretion system EAG14_04295 ENOG4105DEN Luciferase family EAG14_04310 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) EAG14_04315 ENOG4108HPI phosphatidate Cytidylyltransferase EAG14_04355 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase EAG14_04360 ENOG4105E2X shikimate dehydrogenase EAG14_04380 ENOG4105IPS esterase EAG14_04390 ENOG4105CNI cell division protein FtsW EAG14_04410 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EAG14_04420 ENOG4105DFU Cell wall formation (By similarity) EAG14_04425 ENOG4105C26 Dehydrogenase EAG14_04430 ENOG4105C5I Dehydrogenase EAG14_04440 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase EAG14_04445 ENOG4105FDP GntR family transcriptional regulator EAG14_04450 ENOG4105E9Z Nad-dependent epimerase dehydratase EAG14_04460 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EAG14_04470 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EAG14_04485 ENOG4105C0H protease EAG14_04490 ENOG4105XJC Two component transcriptional regulator (Winged helix family EAG14_04495 ENOG4105DHQ Histidine kinase EAG14_04500 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EAG14_04505 ENOG4108UK5 Transposase EAG14_04530 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EAG14_04580 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EAG14_04590 ENOG4105C2D reductase EAG14_04595 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EAG14_04620 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EAG14_04670 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EAG14_04675 ENOG4106RE7 Cytochrome EAG14_04690 ENOG4107HP6 Transcriptional regulator EAG14_04700 ENOG4107QNJ CoA-transferase subunit B EAG14_04705 ENOG4105CHU acetyl-coa acetyltransferase EAG14_04710 ENOG4105CHR reductase EAG14_04730 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein EAG14_04735 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EAG14_04740 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EAG14_04765 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EAG14_04770 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EAG14_04775 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EAG14_04780 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EAG14_04785 ENOG4107TUY Histidine kinase EAG14_04795 ENOG4105CRE cytochrome C EAG14_04800 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY EAG14_04825 ENOG4108ZAF Molybdopterin EAG14_04830 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EAG14_04840 ENOG4107RGH Aldehyde dehydrogenase EAG14_04845 ENOG4105BZU Histidine kinase EAG14_04850 ENOG4105WH1 Two component transcriptional regulator luxr family EAG14_04865 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EAG14_04880 ENOG4107RZC phospholipase d EAG14_04890 ENOG4108R6K riboflavin synthase, subunit alpha EAG14_04895 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EAG14_04930 ENOG4105KHS type IV fimbrial pilin protein EAG14_04940 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EAG14_04945 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EAG14_04955 ENOG4105CP7 Triose-phosphate isomerase EAG14_04960 ENOG4107EJC Preprotein translocase subunit SecG EAG14_04970 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EAG14_04975 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EAG14_04980 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EAG14_04985 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EAG14_04990 ENOG4105GKE subunit e EAG14_04995 ENOG4107QIZ NADH dehydrogenase EAG14_05000 ENOG4108IEH NADH dehydrogenase subunit g EAG14_05005 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) EAG14_05010 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EAG14_05015 ENOG4105DF2 NADH dehydrogenase subunit j EAG14_05020 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EAG14_05030 ENOG4105C8S subunit m EAG14_05035 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EAG14_05050 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_05080 ENOG4105VN1 Heat shock protein EAG14_05085 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EAG14_05090 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EAG14_05095 ENOG4105C2C drug resistance transporter, Bcr CflA EAG14_05105 ENOG4105CZX twitching motility protein EAG14_05110 ENOG4105D82 Glutamate dehydrogenase EAG14_05115 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase EAG14_05120 ENOG4105DND Transcriptional regulator EAG14_05125 ENOG4105CH2 amidohydrolase EAG14_05135 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EAG14_05140 ENOG4105DQR SNARE associated Golgi EAG14_05150 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EAG14_05155 ENOG4105K8N protein family UPF0079, ATPase EAG14_05160 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EAG14_05175 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EAG14_05190 ENOG4105D58 Diguanylate phosphodiesterase EAG14_05195 ENOG4105ED9 Protein of unknown function (DUF455) EAG14_05200 ENOG4108Z0R Transferase EAG14_05205 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EAG14_05220 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) EAG14_05225 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EAG14_05235 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EAG14_05240 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EAG14_05245 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EAG14_05250 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EAG14_05260 ENOG4108YZY peptidylprolyl cis-trans isomerase EAG14_05265 ENOG4105EZE Cupin 4 family protein EAG14_05280 ENOG4105Q2H domain protein EAG14_05285 ENOG4105GJM (LipO)protein EAG14_05290 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EAG14_05305 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EAG14_05310 ENOG4105E4C Lytic transglycosylase catalytic EAG14_05315 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EAG14_05325 ENOG4108EC8 DNA internalization-related competence protein ComEC EAG14_05340 ENOG4105VYA Uncharacterized conserved protein (DUF2132) EAG14_05365 ENOG4105ETP RND efflux system, outer membrane lipoprotein EAG14_05405 ENOG4105E0K tonB-dependent siderophore receptor EAG14_05410 ENOG4105E0K tonB-dependent siderophore receptor EAG14_05415 ENOG4105E0K tonB-dependent siderophore receptor EAG14_05440 ENOG4105D0M Protease HtpX homolog EAG14_05445 ENOG4105CNM Receptor EAG14_05450 ENOG4105E0K tonB-dependent siderophore receptor EAG14_05470 ENOG4108UQY Iron-storage protein EAG14_05480 ENOG4108JU3 Alkyl hydroperoxide reductase EAG14_05485 ENOG4105D05 Receptor EAG14_05495 ENOG4106QJH hemin transport protein EAG14_05500 ENOG4107R4I Periplasmic binding protein EAG14_05505 ENOG4105EHG Permease protein EAG14_05510 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) EAG14_05520 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EAG14_05525 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EAG14_05535 ENOG4107QN1 sodium solute EAG14_05545 ENOG4108V1T peptidylprolyl cis-trans isomerase EAG14_05555 ENOG4108W5M transcriptional regulator EAG14_05560 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EAG14_05565 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EAG14_05575 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_05605 ENOG4105CJ2 (LipO)protein EAG14_05610 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EAG14_05620 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EAG14_05625 ENOG4105CEY Amp-dependent synthetase and ligase EAG14_05635 ENOG4105DGI Alkaline phosphatase EAG14_05640 ENOG4105BZU Histidine kinase EAG14_05650 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) EAG14_05660 ENOG4108K5P (LipO)protein EAG14_05665 ENOG4105C34 Pseudouridine synthase EAG14_05670 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EAG14_05680 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EAG14_05685 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EAG14_05700 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EAG14_05705 ENOG4105CUT histidyl-tRNA synthetase EAG14_05715 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EAG14_05720 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EAG14_05725 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EAG14_05730 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EAG14_05735 ENOG4107QJR hflk protein EAG14_05740 ENOG4105EPW hflc protein EAG14_05745 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) EAG14_05750 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EAG14_05755 ENOG4108UGV hypoxanthine phosphoribosyltransferase EAG14_05785 ENOG4105I08 Pseudouridine synthase EAG14_05815 ENOG4105C5F glutamine synthetase EAG14_05825 ENOG4105CUX Signal transduction histidine kinase EAG14_05830 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EAG14_05835 ENOG4105CGK Exodeoxyribonuclease III EAG14_05840 ENOG4105BZU Histidine kinase EAG14_05845 ENOG4105DNP FAD linked oxidase domain protein EAG14_05860 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) EAG14_05875 ENOG4108SF5 RNA Polymerase EAG14_05880 ENOG4108S3W Anti-feci sigma factor, fecr EAG14_05895 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EAG14_05900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EAG14_05905 ENOG4105DEI Mannitol dehydrogenase EAG14_05910 ENOG41075H3 AraC family transcriptional regulator EAG14_05915 ENOG4105CMG Carbohydrate kinase EAG14_05920 ENOG4105D7K pfkb domain protein EAG14_05960 ENOG4105CQB FAD linked oxidase domain protein EAG14_05970 ENOG4107S2Z UPF0761 membrane protein EAG14_05985 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EAG14_06000 ENOG4105BZU Histidine kinase EAG14_06005 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EAG14_06010 ENOG4105D8G Major Facilitator superfamily EAG14_06020 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EAG14_06025 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EAG14_06030 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division EAG14_06040 ENOG4108R6G acetyltransferase EAG14_06055 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EAG14_06060 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EAG14_06065 ENOG4105MWK D-amino acid dehydrogenase, small subunit EAG14_06075 ENOG4105CE9 30S ribosomal protein S2 EAG14_06080 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EAG14_06090 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EAG14_06100 ENOG4105KNE Phosphatidate cytidylyltransferase EAG14_06105 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EAG14_06110 ENOG4105DZP Membrane-associated zinc metalloprotease EAG14_06115 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EAG14_06125 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EAG14_06130 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) EAG14_06135 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EAG14_06140 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EAG14_06145 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EAG14_06150 ENOG4108RWN rrna methyltransferase EAG14_06165 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EAG14_06170 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EAG14_06185 ENOG4105HBR Rna-binding protein EAG14_06190 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) EAG14_06195 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EAG14_06205 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EAG14_06220 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EAG14_06240 ENOG4105C9X ppx gppa phosphatase EAG14_06250 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) EAG14_06255 ENOG4105C8U phosphate abc transporter EAG14_06260 ENOG4105E2Z phosphate ABC transporter (Permease EAG14_06265 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EAG14_06270 ENOG4108UTW Plays a role in the regulation of phosphate uptake EAG14_06275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EAG14_06285 ENOG4107QI1 Mate efflux family protein EAG14_06295 ENOG4105NRA 50s ribosomal protein l31 type b EAG14_06300 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EAG14_06305 ENOG4105K63 Thioredoxin EAG14_06335 ENOG4107QMP dna polymerase iii subunits gamma and tau EAG14_06340 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EAG14_06345 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EAG14_06365 ENOG4105E9H Lytic Murein transglycosylase EAG14_06370 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EAG14_06380 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EAG14_06390 ENOG4105BZS acriflavin resistance protein EAG14_06395 ENOG4105DTD Dehydrogenase EAG14_06435 ENOG4108NVM synthesis repressor PhaR EAG14_06440 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) EAG14_06455 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EAG14_06470 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EAG14_06475 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EAG14_06490 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EAG14_06500 ENOG4105K70 DNA-binding protein EAG14_06510 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EAG14_06530 ENOG4105C1J atp-dependent rna helicase EAG14_06535 ENOG4105C5H ABC transporter EAG14_06550 ENOG4105KXX peptidase s58 dmpa EAG14_06570 ENOG4107R16 Multicopper oxidase EAG14_06595 ENOG4105VUF Transcriptional regulator EAG14_06685 ENOG4105C6T cysteine synthase EAG14_06690 ENOG4105E09 nadh pyrophosphatase EAG14_06695 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) EAG14_06700 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EAG14_06705 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EAG14_06725 ENOG4105CXN decarboxylase EAG14_06735 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EAG14_06740 ENOG4105E43 Extracellular solute-binding protein, family 5 EAG14_06745 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component EAG14_06760 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component EAG14_06790 ENOG4105EJC lysr family transcriptional regulator EAG14_06800 ENOG4105EBM Alpha Beta Hydrolase Fold protein EAG14_06805 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EAG14_06810 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EAG14_06830 ENOG4105DUM transcriptional regulator, lysR family EAG14_06860 ENOG4105ETE Transcriptional regulator (LacI family EAG14_06870 ENOG4105DIA mandelate racemase muconate lactonizing EAG14_06875 ENOG4105CC0 LysR family Transcriptional regulator EAG14_06895 ENOG4105CPQ Dehydrogenase EAG14_06900 ENOG4108JU3 Alkyl hydroperoxide reductase EAG14_06905 ENOG4108Z40 Transcriptional regulator EAG14_06925 ENOG4105CSH Transporter EAG14_06930 ENOG4107V59 shikimate EAG14_06935 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase EAG14_06955 ENOG4105C0D helicase EAG14_06960 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EAG14_06965 ENOG4105CHV Transcription elongation factor NusA EAG14_06970 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EAG14_06975 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EAG14_06980 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EAG14_06995 ENOG4105E39 Enoyl-CoA hydratase EAG14_07000 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EAG14_07005 ENOG4108Z1B Cyclase dehydrase EAG14_07010 ENOG4105VDB UPF0125 protein EAG14_07020 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EAG14_07035 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EAG14_07080 ENOG4105C26 Dehydrogenase EAG14_07085 ENOG4105EW9 transcriptional regulator AsnC family EAG14_07095 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EAG14_07105 ENOG4108ZJF Glcg protein EAG14_07120 ENOG4105M8F Biopolymer transport protein exbD tolR EAG14_07145 ENOG4107E2E PKHD-type hydroxylase EAG14_07150 ENOG4108IU3 tonb-dependent siderophore receptor EAG14_07170 ENOG4108I9X Isocitrate lyase EAG14_07175 ENOG4105C22 threonyL-tRNA synthetase EAG14_07180 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EAG14_07185 ENOG4105VJV 50s ribosomal protein L35 EAG14_07190 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EAG14_07195 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EAG14_07200 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EAG14_07205 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) EAG14_07210 ENOG4108XDN Transcriptional regulator EAG14_07240 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 EAG14_07245 ENOG4105CD8 aminopeptidase N EAG14_07250 ENOG4107VXZ Hydrolase EAG14_07260 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EAG14_07265 ENOG4108K3Z AraC family transcriptional regulator EAG14_07290 ENOG4105C32 Amino acid ABC transporter (Permease) EAG14_07295 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EAG14_07300 ENOG4105C0Z ABC transporter EAG14_07305 ENOG4108IV0 ABC, transporter EAG14_07315 ENOG4105CPC Aldo Keto reductase EAG14_07330 ENOG4105DND Transcriptional regulator EAG14_07335 ENOG4108Z66 YbaK ebsC protein EAG14_07340 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EAG14_07355 ENOG4108VPT UPF0234 protein EAG14_07360 ENOG4105D4A Cell wall formation (By similarity) EAG14_07365 ENOG4105BZU Histidine kinase EAG14_07375 ENOG4105CDH Citrulline--aspartate ligase EAG14_07380 ENOG4105NBK UPF0345 protein EAG14_07390 ENOG4105KUZ arsenate reductase EAG14_07395 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EAG14_07410 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase EAG14_07415 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EAG14_07450 ENOG4105BZU Histidine kinase EAG14_07460 ENOG4107QKW extracellular solute-binding protein family 1 EAG14_07465 ENOG4105VEJ Heat shock protein EAG14_07470 ENOG4105DHQ Histidine kinase EAG14_07500 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EAG14_07510 ENOG4105C0Z ABC transporter EAG14_07515 ENOG4108IV0 ABC, transporter EAG14_07525 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EAG14_07530 ENOG4106BE1 Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers (By similarity) EAG14_07555 ENOG4105EFZ amidohydrolase EAG14_07565 ENOG4105CHJ isochorismatase hydrolase EAG14_07575 ENOG4105EQ1 Transcriptional regulator EAG14_07600 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein EAG14_07615 ENOG410816E Phosphotransferase enzyme family EAG14_07620 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EAG14_07645 ENOG4105DAN ATP-dependent protease EAG14_07650 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EAG14_07655 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant EAG14_07680 ENOG4105DHQ Histidine kinase EAG14_07695 ENOG4105BZU Histidine kinase EAG14_07710 ENOG4105FE1 phytoene synthase EAG14_07720 ENOG4105EJQ L-serine dehydratase EAG14_07745 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EAG14_07750 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EAG14_07755 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EAG14_07760 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EAG14_07790 ENOG4108VKG metal-dependent hydrolase EAG14_07795 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EAG14_07810 ENOG4108TEB UPF0114 protein EAG14_07815 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EAG14_07825 ENOG4105W2Z cytochrome C, class I EAG14_07835 ENOG4105C01 Dihydroxy-acid dehydratase EAG14_07840 ENOG4108UWD Iron-storage protein EAG14_07850 ENOG4108S3W Anti-feci sigma factor, fecr EAG14_07860 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) EAG14_07875 ENOG4105DRR Transcriptional regulator, GntR family EAG14_07895 ENOG4105CEY Amp-dependent synthetase and ligase EAG14_07905 ENOG4108PZW LysR family Transcriptional regulator EAG14_07910 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EAG14_07920 ENOG4105C32 Amino acid ABC transporter (Permease) EAG14_07925 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EAG14_07930 ENOG4108IUZ ABC transporter EAG14_07935 ENOG4108IV0 ABC, transporter EAG14_07955 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i EAG14_07990 ENOG4105DS0 Transcriptional regulator, Crp Fnr family EAG14_08005 ENOG4105DHT Metal Dependent Phosphohydrolase EAG14_08015 ENOG4105HF0 Membrane EAG14_08030 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) EAG14_08035 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EAG14_08040 ENOG4108YZT Adenosylcobinamide kinase EAG14_08045 ENOG4108HUF Transporter EAG14_08050 ENOG4105EHG Permease protein EAG14_08055 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) EAG14_08060 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase EAG14_08065 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase EAG14_08075 ENOG4107Z6W Protein CrcB homolog EAG14_08080 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EAG14_08110 ENOG4105KJM monovalent cation h antiporter subunit g EAG14_08115 ENOG4105W4C monovalent cation H antiporter subunit F EAG14_08120 ENOG4105SC1 monovalent cation H antiporter subunit E EAG14_08125 ENOG4107R4Z monovalent cation h antiporter subunit d EAG14_08130 ENOG4108ZE9 Monovalent cation H antiporter subunit C EAG14_08135 ENOG4105D65 subunit l EAG14_08145 ENOG4105CFV Tetratricopeptide repeat protein EAG14_08155 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) EAG14_08160 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EAG14_08165 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EAG14_08180 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EAG14_08185 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EAG14_08190 ENOG4105UYK outer membrane protein a EAG14_08195 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EAG14_08200 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EAG14_08265 ENOG4105WH1 Two component transcriptional regulator luxr family EAG14_08270 ENOG4105ENE Histidine kinase EAG14_08275 ENOG4108WFY phasin family EAG14_08280 ENOG4105DGU Histone deacetylase EAG14_08290 ENOG4107RH7 Nicotinate phosphoribosyltransferase EAG14_08310 ENOG4107QSV RmuC domain protein EAG14_08325 ENOG4105CIH Imidazole acetol-phosphate transaminase EAG14_08340 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EAG14_08345 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EAG14_08355 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EAG14_08365 ENOG4105F38 ABC transporter, permease EAG14_08375 ENOG4107XBN GntR Family Transcriptional Regulator EAG14_08390 ENOG41086VY Fic/DOC family EAG14_08395 ENOG4105CSM endonuclease III EAG14_08400 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EAG14_08405 ENOG41069P5 Protein slyX homolog EAG14_08420 ENOG4105C1J atp-dependent rna helicase EAG14_08445 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) EAG14_08460 ENOG4105EAC phosphoserine phosphatase EAG14_08470 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EAG14_08490 ENOG4108JA2 transcriptioN-repair coupling factor EAG14_08495 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) EAG14_08500 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EAG14_08510 ENOG4105E0F Histidine kinase EAG14_08515 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EAG14_08540 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EAG14_08545 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EAG14_08570 ENOG4105C26 Dehydrogenase EAG14_08575 ENOG4105F2I Transposase EAG14_08600 ENOG4105F0N pyrophosphate phospho-hydrolase EAG14_08605 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_08615 ENOG4105C4K Nad synthetase EAG14_08620 ENOG4108YZA Nitrogen regulatory protein pii EAG14_08625 ENOG4108URH decarboxylase EAG14_08630 ENOG41080IJ Diacylglycerol kinase EAG14_08650 ENOG4105JVQ RNA Polymerase EAG14_08655 ENOG4105C7K acetolactate synthase EAG14_08660 ENOG4108ZP8 Acetolactate synthase small subunit EAG14_08665 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EAG14_08670 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EAG14_08675 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EAG14_08680 ENOG41061WM D-Alanyl-D-Alanine EAG14_08685 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region EAG14_08690 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate EAG14_08695 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) EAG14_08710 ENOG4105WD1 Membrane EAG14_08715 ENOG4108IQK o-acetylhomoserine EAG14_08720 ENOG4105CFP Peptidase U32 EAG14_08755 ENOG4108Z6B deaminase EAG14_08760 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EAG14_08770 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EAG14_08775 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) EAG14_08785 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EAG14_08790 ENOG4108ETH Formylglycinamide ribotide synthetase EAG14_08810 ENOG4105BZU Histidine kinase EAG14_08830 ENOG4105BZU Histidine kinase EAG14_08835 ENOG4105BZU Histidine kinase EAG14_08850 ENOG4105PGM cation diffusion facilitator family transporter EAG14_08880 ENOG4107QKV phosphomannomutase EAG14_08890 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase EAG14_08900 ENOG4105DFG type I secretion outer membrane protein EAG14_08910 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EAG14_08925 ENOG4108R86 Transcriptional regulator EAG14_08930 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EAG14_08940 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EAG14_08965 ENOG4105UGU tonB-dependent Receptor EAG14_08990 ENOG4108UKI Enoyl-CoA hydratase EAG14_08995 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EAG14_09005 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EAG14_09010 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EAG14_09035 ENOG4105D3G Pseudouridine synthase EAG14_09040 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_09050 ENOG4105BZM domain protein EAG14_09070 ENOG4105BZU Histidine kinase EAG14_09075 ENOG4105C0A alcohol dehydrogenase EAG14_09095 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) EAG14_09100 ENOG4105HHA aminodeoxychorismate lyase EAG14_09105 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EAG14_09110 ENOG4107QRG dna polymerase iii EAG14_09120 ENOG4105F8V Hydrolase, tatD family EAG14_09130 ENOG4105BZ1 (ABC) transporter EAG14_09135 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) EAG14_09140 ENOG4105KCK Peptidoglycan-associated lipoprotein EAG14_09150 ENOG4105CUZ uba thif-type nad fad binding protein EAG14_09160 ENOG4105CDY transcriptional regulatory protein EAG14_09165 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EAG14_09185 ENOG4105BZU Histidine kinase EAG14_09190 ENOG4105BZU Histidine kinase EAG14_09200 ENOG4105D0S secretion protein (HlyD EAG14_09205 ENOG4105CJ1 ABC, transporter EAG14_09210 ENOG4105CMI transporter EAG14_09215 ENOG4105DZC cytosine deaminase EAG14_09230 ENOG41083U2 ABC transporter, permease EAG14_09235 ENOG4108JQ9 ABC transporter EAG14_09240 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EAG14_09245 ENOG4107TFB basic membrane EAG14_09250 ENOG4105F64 nitrite reductase EAG14_09255 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EAG14_09265 ENOG4106PMH Extracellular solute-binding protein family 3 EAG14_09270 ENOG4105DRP amino acid AbC transporter EAG14_09285 ENOG4105D7A ATP-binding protein EAG14_09290 ENOG4105CDY transcriptional regulatory protein EAG14_09295 ENOG4105C12 Phosphoribosylglycinamide synthetase EAG14_09300 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) EAG14_09305 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) EAG14_09310 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EAG14_09315 ENOG4108Z03 MAF-like protein EAG14_09320 ENOG4105C03 ribonuclease EAG14_09335 ENOG4105EEX Two component transcriptional regulator (Winged helix family EAG14_09340 ENOG4105C08 Histidine kinase EAG14_09345 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EAG14_09350 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EAG14_09355 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EAG14_09365 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EAG14_09385 ENOG4105CHM Aminotransferase EAG14_09390 ENOG4107R11 Transcriptional regulator EAG14_09410 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EAG14_09430 ENOG4108JQ1 Dehydrogenase EAG14_09435 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EAG14_09440 ENOG4105HDK L-asparaginase EAG14_09445 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EAG14_09450 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) EAG14_09455 ENOG4105W49 UPF0434 protein EAG14_09460 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) EAG14_09465 ENOG4108ZZF transport protein (ExbD) EAG14_09475 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EAG14_09495 ENOG4107T0D ABC, transporter EAG14_09500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EAG14_09510 ENOG4105DEF Extracellular solute-binding protein, family 5 EAG14_09555 ENOG4105C1G acyl-Coa dehydrogenase EAG14_09565 ENOG4105C26 Dehydrogenase EAG14_09570 ENOG4105EVZ LysR family transcriptional regulator EAG14_09585 ENOG4105KWG Pfam:DUF1696 EAG14_09600 ENOG4105C0R drug resistance transporter emrb qaca subfamily EAG14_09605 ENOG4105CW7 secretion protein, HlyD family EAG14_09610 ENOG4105ETP RND efflux system, outer membrane lipoprotein EAG14_09620 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EAG14_09625 ENOG4105DZ2 Transcriptional regulator EAG14_09650 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EAG14_09680 ENOG4105CAY ferredoxin--nadp reductase EAG14_09685 ENOG4108Z4U Ferredoxin EAG14_09690 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) EAG14_09695 ENOG4105C11 sulfate adenylyltransferase), subunit 2 EAG14_09700 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EAG14_09715 ENOG4107TSN permease EAG14_09725 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) EAG14_09730 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EAG14_09735 ENOG4108UZX fmn reductase EAG14_09740 ENOG4105GVF (ABC) transporter EAG14_09745 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EAG14_09755 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EAG14_09760 ENOG4105GVF (ABC) transporter EAG14_09765 ENOG4105E2Y ABC, transporter EAG14_09775 ENOG4105J7D transcriptional regulator EAG14_09780 ENOG4105CB2 alcohol dehydrogenase EAG14_09800 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) EAG14_09805 ENOG4107Z3H Transcriptional regulator, TetR family EAG14_09820 ENOG4105BZU Histidine kinase EAG14_09855 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EAG14_09860 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EAG14_09870 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EAG14_09880 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA EAG14_09885 ENOG4105C0B DNA polymerase III (alpha subunit) EAG14_09895 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EAG14_09905 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EAG14_09910 ENOG4105BZ4 penicillin-binding protein EAG14_09940 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EAG14_09955 ENOG4105CHU acetyl-coa acetyltransferase EAG14_09960 ENOG4105CHR reductase EAG14_09965 ENOG4105C5H ABC transporter EAG14_09970 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) EAG14_09975 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EAG14_09980 ENOG4105CZX twitching motility protein EAG14_09985 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) EAG14_09990 ENOG4105CHM Aminotransferase EAG14_09995 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_10000 ENOG4108R3D Electron transport complex EAG14_10020 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EAG14_10030 ENOG4108RYR transcriptional regulator AsnC family EAG14_10040 ENOG4108IQE Amp-dependent synthetase and ligase EAG14_10045 ENOG4105DRR Transcriptional regulator, GntR family EAG14_10060 ENOG4105DJT lAO AO transport system ATPase EAG14_10065 ENOG4107QX3 carboxylase EAG14_10075 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EAG14_10100 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EAG14_10105 ENOG4105BZU Histidine kinase EAG14_10130 ENOG41080HT Transcriptional regulator, arsr family EAG14_10145 ENOG4107S76 domain protein EAG14_10205 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EAG14_10220 ENOG4105DD5 Flagellar motor switch protein EAG14_10230 ENOG4105BZE flagellar hook protein, FlgE EAG14_10235 ENOG410822I Flagellar hook capping protein EAG14_10270 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EAG14_10275 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EAG14_10280 ENOG4108ZC9 flagellar basal-body rod protein flgc EAG14_10290 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) EAG14_10295 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) EAG14_10305 ENOG4105CGA flagellar basal-body rod protein FlgG EAG14_10310 ENOG4108JQA flagellar EAG14_10315 ENOG4105D7B Flagellar biosynthesis protein flha EAG14_10320 ENOG4105D00 flagellar biosynthetic protein flhB EAG14_10325 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EAG14_10330 ENOG4105VS8 Flagellar biosynthetic protein fliq EAG14_10430 ENOG4105CHR reductase EAG14_10435 ENOG4105UQX Mate efflux family protein EAG14_10460 ENOG4108UYE Lactoylglutathione lyase EAG14_10470 ENOG4105K4H Nlp p60 protein EAG14_10490 ENOG4105JN3 extra-cytoplasmic solute receptor family protein EAG14_10515 ENOG4105XJC Two component transcriptional regulator (Winged helix family EAG14_10530 ENOG4105C0D helicase EAG14_10540 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EAG14_10565 ENOG4105DR4 Methyltransferase EAG14_10570 ENOG4107VIJ nudix hydrolase EAG14_10580 ENOG4105E98 transcriptional regulator DeoR family EAG14_10590 ENOG4106UX7 integral membrane protein EAG14_10600 ENOG4105ES5 Histidine kinase EAG14_10630 ENOG4105CZK Aspartate kinase EAG14_10650 ENOG4107QN2 dihydrolipoyl dehydrogenase EAG14_10655 ENOG4107QSN dihydrolipoamide acetyltransferase EAG14_10660 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EAG14_10665 ENOG4105BZU Histidine kinase EAG14_10670 ENOG4108ZXC Two component transcriptional regulator, luxr family EAG14_10675 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EAG14_10680 ENOG4105DGW oligopeptidase A EAG14_10690 ENOG4105E66 phosphoriboisomerase A EAG14_10695 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) EAG14_10715 ENOG4105D5U fad dependent oxidoreductase EAG14_10720 ENOG41067B5 Histone deacetylase superfamily protein EAG14_10735 ENOG4107RZZ dna polymerase iii epsilon subunit EAG14_10740 ENOG4108ZIT Ferredoxin, 2FE-2S EAG14_10745 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB EAG14_10765 ENOG4105C3J Cysteine desulfurase EAG14_10770 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family EAG14_10775 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EAG14_10780 ENOG4105CGF Aromatic amino acid aminotransferase EAG14_10790 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EAG14_10795 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F EAG14_10815 ENOG4105CCT upf0313 protein EAG14_10850 ENOG4108JQ7 (ABC) transporter EAG14_10855 ENOG4105C3U ABC transporter EAG14_10860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EAG14_10865 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EAG14_10870 ENOG4105E1J oxidoreductase EAG14_10880 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EAG14_10890 ENOG4105FC8 fad dependent oxidoreductase EAG14_10895 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EAG14_10905 ENOG4105BZC d-serine deaminase EAG14_10945 ENOG4105C2N RNA methyltransferase TrmH family group 3 EAG14_10950 ENOG4108I0Y (ABC) transporter EAG14_10955 ENOG4108UJV acyl-CoA thioesterase i EAG14_10970 ENOG4105C28 cystathionine EAG14_10985 ENOG4105BZU Histidine kinase EAG14_10995 ENOG4105C72 UPF0176 protein EAG14_11000 ENOG4105EUB pirin domain protein EAG14_11015 ENOG4105EQ1 Transcriptional regulator EAG14_11025 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) EAG14_11030 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EAG14_11035 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria EAG14_11045 ENOG4105ETT transcriptional Regulator, LysR family EAG14_11055 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EAG14_11060 ENOG4105BZS acriflavin resistance protein EAG14_11065 ENOG4105C1P efflux transporter, rnd family, mfp subunit EAG14_11080 ENOG4105C72 UPF0176 protein EAG14_11090 ENOG4105BZU Histidine kinase EAG14_11095 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) EAG14_11100 ENOG4108IJ6 ABC transporter EAG14_11110 ENOG4108I5D sulfate abc transporter EAG14_11115 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EAG14_11125 ENOG4105D3R alkyl hydroperoxide reductase EAG14_11130 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_11145 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EAG14_11165 ENOG4105CJB Exodeoxyribonuclease I EAG14_11170 ENOG4105CVE Lytic murein transglycosylase EAG14_11175 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EAG14_11185 ENOG4105CK2 sodium dicarboxylate symporter EAG14_11190 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EAG14_11195 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EAG14_11200 ENOG4105C0B DNA polymerase III (alpha subunit) EAG14_11205 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EAG14_11210 ENOG4105DVT helicase EAG14_11225 ENOG4105D6Z AFG1 family ATPase EAG14_11230 ENOG4107QN2 dihydrolipoyl dehydrogenase EAG14_11235 ENOG4105C7S Dehydrogenase EAG14_11240 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EAG14_11260 ENOG4105CEY Amp-dependent synthetase and ligase EAG14_11265 ENOG4105CQ7 ATP-dependent helicase EAG14_11280 ENOG4108EKC n-acetylglutamate synthase EAG14_11290 ENOG4105HEI LysR family (Transcriptional regulator EAG14_11295 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EAG14_11305 ENOG4105BZU Histidine kinase EAG14_11310 ENOG4105BZU Histidine kinase EAG14_11315 ENOG4105D01 (LipO)protein EAG14_11325 ENOG4105CKD glutathione-regulated potassium-efflux system protein EAG14_11335 ENOG4108UMI ABC transporter, permease EAG14_11340 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EAG14_11345 ENOG4105E5M Multidrug resistance protein D EAG14_11350 ENOG4107QNJ CoA-transferase subunit B EAG14_11365 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EAG14_11385 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase EAG14_11390 ENOG4105EW9 transcriptional regulator AsnC family EAG14_11395 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EAG14_11405 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EAG14_11410 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EAG14_11415 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EAG14_11420 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EAG14_11430 ENOG4108V1T peptidylprolyl cis-trans isomerase EAG14_11435 ENOG4107TXC Transcriptional regulator EAG14_11455 ENOG4105D3G Pseudouridine synthase EAG14_11475 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) EAG14_11490 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_11495 ENOG4108KTG Membrane protein, drug metabolite transporter EAG14_11500 ENOG4108ZT1 Transcriptional regulator EAG14_11505 ENOG410904N short-chain dehydrogenase reductase EAG14_11510 ENOG4105CHU acetyl-coa acetyltransferase EAG14_11520 ENOG41081QV Universal stress protein EAG14_11530 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EAG14_11540 ENOG4105DHQ Histidine kinase EAG14_11545 ENOG4105XJC Two component transcriptional regulator (Winged helix family EAG14_11550 ENOG4105D4T Citrate transporter EAG14_11555 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EAG14_11565 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EAG14_11575 ENOG4105F38 ABC transporter, permease EAG14_11580 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component EAG14_11585 ENOG4105C26 Dehydrogenase EAG14_11665 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EAG14_11685 ENOG4105CSU acyl-Coa dehydrogenase EAG14_11690 ENOG4105CHU acetyl-coa acetyltransferase EAG14_11695 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EAG14_11705 ENOG4108IV0 ABC, transporter EAG14_11710 ENOG4105C0Z ABC transporter EAG14_11730 ENOG4105CEY Amp-dependent synthetase and ligase EAG14_11735 ENOG4105CNG UPF0061 protein EAG14_11740 ENOG4105E0X reductase EAG14_11745 ENOG4107835 probably involved in intracellular septation (By similarity) EAG14_11755 ENOG4107TF3 peptidylprolyl cis-trans isomerase EAG14_11770 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EAG14_11800 ENOG4105CI2 imidazolone-5-propionate hydrolase EAG14_11805 ENOG41090B9 response to stress EAG14_11810 ENOG4105CGP Urocanate hydratase EAG14_11815 ENOG4105C84 Histidine ammonia-lyase EAG14_11820 ENOG4105CZE histidine utilization repressor EAG14_11830 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EAG14_11840 ENOG4105E0F Histidine kinase EAG14_11845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EAG14_11870 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EAG14_11875 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) EAG14_11885 ENOG4105C8N cysteinyl-tRNA synthetase EAG14_11910 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) EAG14_11915 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) EAG14_11920 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EAG14_11925 ENOG4108YXU transcriptional regulator AsnC family EAG14_11950 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EAG14_11955 ENOG4108YZN class I peptide chain release factor EAG14_11965 ENOG4105CX6 glutaminyL-tRNA synthetase EAG14_12010 ENOG4105BZU Histidine kinase EAG14_12025 ENOG4105D2X ABC transporter substrate-binding protein EAG14_12030 ENOG4108Z6B deaminase EAG14_12045 ENOG4105F87 Dehydratase EAG14_12050 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) EAG14_12080 ENOG4108R99 pseudouridine synthase EAG14_12150 ENOG4105DR9 pseudouridine synthase EAG14_12165 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EAG14_12180 ENOG4105D9M gamma-glutamylcysteine synthetase EAG14_12185 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr EAG14_12200 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EAG14_12205 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EAG14_12210 ENOG4107YIM Involved in the transcription termination process (By similarity) EAG14_12215 ENOG4105CHM Aminotransferase EAG14_12220 ENOG4107YD3 Thioesterase EAG14_12225 ENOG4105E02 MotA TolQ exbB proton channel EAG14_12230 ENOG4105M8F Biopolymer transport protein exbD tolR EAG14_12255 ENOG4107QIJ Aconitate hydratase 2 EAG14_12270 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EAG14_12275 ENOG4105FDP GntR family transcriptional regulator EAG14_12295 ENOG4105E33 succinate dehydrogenase EAG14_12300 ENOG41060IS Flavinator of succinate dehydrogenase EAG14_12305 ENOG4105BZN citrate synthase EAG14_12330 ENOG4105DIJ Phosphoethanolamine transferase EAG14_12340 ENOG4105C26 Dehydrogenase EAG14_12345 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EAG14_12350 ENOG4108JQ6 ABC transporter EAG14_12355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EAG14_12370 ENOG4105CJP fad dependent oxidoreductase EAG14_12380 ENOG4105C26 Dehydrogenase EAG14_12390 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase EAG14_12395 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EAG14_12400 ENOG4108RYR transcriptional regulator AsnC family EAG14_12430 ENOG4105JN3 extra-cytoplasmic solute receptor family protein EAG14_12440 ENOG4108Z9W Outer membrane porin EAG14_12445 ENOG4105DUM transcriptional regulator, lysR family EAG14_12460 ENOG4105CPC Aldo Keto reductase EAG14_12465 ENOG4105ENX hydrolase EAG14_12480 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_12490 ENOG4105CH2 amidohydrolase EAG14_12510 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EAG14_12515 ENOG4105NXH GreA GreB family elongation factor EAG14_12530 ENOG4105C4M (Ubiquinol oxidase) subunit I EAG14_12535 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EAG14_12545 ENOG4105CSU acyl-Coa dehydrogenase EAG14_12550 ENOG4105C10 Electron transfer flavoprotein EAG14_12555 ENOG4105BZJ Electron transfer flavoprotein EAG14_12570 ENOG4105DGU Histone deacetylase EAG14_12575 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EAG14_12585 ENOG4105F8C transglutaminase domain-containing protein EAG14_12590 ENOG4105CVE Lytic murein transglycosylase EAG14_12605 ENOG4105EAB amino acid AbC transporter EAG14_12610 ENOG4105CDA abc transporter atp-binding protein EAG14_12620 ENOG4105CH2 amidohydrolase EAG14_12630 ENOG4105DEN Luciferase family EAG14_12635 ENOG4105ES9 amino acid EAG14_12645 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EAG14_12650 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EAG14_12655 ENOG410624X efflux transporter, rnd family, mfp subunit EAG14_12660 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EAG14_12675 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EAG14_12690 ENOG4105I5W Transporter EAG14_12700 ENOG4105D7T ABC transporter EAG14_12705 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_12710 ENOG41080XP Cbs domain EAG14_12715 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EAG14_12720 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EAG14_12725 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter EAG14_12730 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EAG14_12735 ENOG4105ETE Transcriptional regulator (LacI family EAG14_12755 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor EAG14_12765 ENOG4105D9P serine threonine protein kinase EAG14_12770 ENOG4108IFG nitrite reductase, (NAD(P)H) EAG14_12785 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EAG14_12790 ENOG4108I0Q anthranilate phosphoribosyltransferase EAG14_12795 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EAG14_12800 ENOG4106R7G Glycoside hydrolase family 5 EAG14_12830 ENOG4105VCC 30S ribosomal protein S21 EAG14_12845 ENOG4105EJC lysr family transcriptional regulator EAG14_12865 ENOG4105D01 (LipO)protein EAG14_12880 ENOG4105JN3 extra-cytoplasmic solute receptor family protein EAG14_12885 ENOG4105CTX dehydratase EAG14_12910 ENOG4105CNV Aldolase EAG14_12915 ENOG4105CMS peptidase U62, modulator of DNA gyrase EAG14_12920 ENOG4105N42 UPF0307 protein EAG14_12925 ENOG4108RIR Molybdenum cofactor biosynthesis protein EAG14_12935 ENOG4105D7W serine acetyltransferase EAG14_12945 ENOG4105ECY inositol monophosphatase EAG14_12955 ENOG4105BZU Histidine kinase EAG14_12965 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EAG14_13000 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EAG14_13015 ENOG4105C2F Histidine kinase EAG14_13020 ENOG4108VAC response regulator EAG14_13030 ENOG4105BZU Histidine kinase EAG14_13035 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EAG14_13060 ENOG410829K Lysine exporter protein (Lyse ygga) EAG14_13065 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) EAG14_13085 ENOG4105BZU Histidine kinase EAG14_13095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EAG14_13100 ENOG4105BZU Histidine kinase EAG14_13105 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EAG14_13115 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family EAG14_13150 ENOG4107W6X Transcriptional regulator EAG14_13160 ENOG4105F4R Transcriptional regulator mode EAG14_13165 ENOG4108Z4X TRANSCRIPTIONal EAG14_13175 ENOG4105CS1 NAD(P)H quinone oxidoreductase EAG14_13185 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EAG14_13195 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) EAG14_13200 ENOG4105BZU Histidine kinase EAG14_13220 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein EAG14_13230 ENOG4105D5T phosphonate abc transporter EAG14_13240 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family EAG14_13250 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EAG14_13255 ENOG4105CH5 extracellular solute-binding protein, family 7 EAG14_13260 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EAG14_13270 ENOG41086K9 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EAG14_13285 ENOG4105KHC sulfurtransferase EAG14_13290 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) EAG14_13295 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region EAG14_13310 ENOG4105BZU Histidine kinase EAG14_13320 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) EAG14_13325 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EAG14_13375 ENOG4105ETT transcriptional Regulator, LysR family EAG14_13380 ENOG4105C1G acyl-Coa dehydrogenase EAG14_13395 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_13400 ENOG4105CSR polyphosphate kinase 2 EAG14_13405 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EAG14_13420 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EAG14_13425 ENOG4105C01 Dihydroxy-acid dehydratase EAG14_13435 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter EAG14_13440 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EAG14_13445 ENOG4105CQB FAD linked oxidase domain protein EAG14_13450 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr EAG14_13455 ENOG4105ERH Fumarylacetoacetate hydrolase EAG14_13460 ENOG4107R88 Chemotaxis protein (CheV) EAG14_13490 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EAG14_13495 ENOG4105DJ0 Poly(A) Polymerase EAG14_13505 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) EAG14_13510 ENOG4105CXB phosphoribosylaminoimidazole synthetase EAG14_13540 ENOG4105CSR polyphosphate kinase 2 EAG14_13555 ENOG41063JG Transcriptional regulator EAG14_13560 ENOG4105CJR Integral membrane protein (MviN EAG14_13565 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) EAG14_13575 ENOG4105C8Y Acetylornithine aminotransferase EAG14_13580 ENOG4105DBV ornithine carbamoyltransferase EAG14_13595 ENOG4105CE1 Ferrous iron transport protein b EAG14_13640 ENOG4105DHQ Histidine kinase EAG14_13645 ENOG4108V3W Chemotaxis protein, CheW EAG14_13650 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_13660 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) EAG14_13670 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) EAG14_13715 ENOG4105DBV ornithine carbamoyltransferase EAG14_13720 ENOG4105MSY salicylate hydroxylase EAG14_13730 ENOG4105BZU Histidine kinase EAG14_13735 ENOG4107QM5 aconitate hydratase EAG14_13740 ENOG4107M1U Histone family protein nucleoid-structuring protein H-NS EAG14_13745 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EAG14_13755 ENOG4105MPD Cytochrome EAG14_13775 ENOG4105DH4 Periplasmic copper-binding protein EAG14_13780 ENOG4105CIG ABC transporter EAG14_13785 ENOG4108T0W nitrous oxide maturation protein NosY EAG14_13800 ENOG4105C1J atp-dependent rna helicase EAG14_13805 ENOG4105CGZ zinc metallopeptidase EAG14_13810 ENOG4105BZU Histidine kinase EAG14_13815 ENOG4105DHP deoxycytidine triphosphate deaminase EAG14_13820 ENOG4107QUY Guanine deaminase EAG14_13830 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_13850 ENOG4105UIB (ABC) transporter EAG14_13855 ENOG4105C2J ABC transporter EAG14_13870 ENOG4105C7W Xanthine dehydrogenase EAG14_13875 ENOG4105BZU Histidine kinase EAG14_13885 ENOG4108Z9W Outer membrane porin EAG14_13895 ENOG4105BZU Histidine kinase EAG14_13915 ENOG4105VT2 5-hydroxyisourate hydrolase EAG14_13930 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EAG14_13975 ENOG4105EJC lysr family transcriptional regulator EAG14_14000 ENOG4105CK2 sodium dicarboxylate symporter EAG14_14005 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_14010 ENOG4105C6K Malic enzyme EAG14_14015 ENOG4108HU6 Metal dependent phosphohydrolase EAG14_14025 ENOG4105D7T ABC transporter EAG14_14030 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EAG14_14040 ENOG4105D78 K07001 NTE family protein EAG14_14045 ENOG4105D7K pfkb domain protein EAG14_14050 ENOG4105CTX dehydratase EAG14_14055 ENOG4107QZW Altronate oxidoreductase EAG14_14060 ENOG4105CPQ Dehydrogenase EAG14_14065 ENOG4105CT1 (ABC) transporter EAG14_14075 ENOG4105EAD ABC transporter EAG14_14090 ENOG4105JXH GntR family transcriptional regulator EAG14_14095 ENOG4105C6Z Gluconate EAG14_14100 ENOG4105ZXK Dehydrogenase EAG14_14110 ENOG4105FB2 class II Aldolase EAG14_14120 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EAG14_14125 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) EAG14_14130 ENOG4108Z9W Outer membrane porin EAG14_14140 ENOG4105CHM Aminotransferase EAG14_14145 ENOG4105F27 Major Facilitator EAG14_14155 ENOG4105F8J Adenylate Guanylate cyclase EAG14_14170 ENOG4105MH5 phosphoesterase PA-phosphatase related protein EAG14_14175 ENOG4108IV0 ABC, transporter EAG14_14185 ENOG4105C0Z ABC transporter EAG14_14190 ENOG4105CNN ABC, transporter EAG14_14195 ENOG4105C32 Amino acid ABC transporter (Permease) EAG14_14205 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein EAG14_14215 ENOG4105BZU Histidine kinase EAG14_14220 ENOG4108JIK carboxylase EAG14_14225 ENOG4105P4J Allophanate hydrolase, subunit 1 EAG14_14235 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) EAG14_14265 ENOG4105BZU Histidine kinase EAG14_14270 ENOG4105CHM Aminotransferase EAG14_14285 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EAG14_14295 ENOG4108YZ9 Urea amidohydrolase subunit gamma EAG14_14305 ENOG4105KI2 Urea amidohydrolase subunit beta EAG14_14310 ENOG4105CQM Urea amidohydrolase subunit alpha EAG14_14315 ENOG4105I4A GCN5-related N-acetyltransferase EAG14_14320 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) EAG14_14325 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) EAG14_14340 ENOG4105DFP Integrase EAG14_14440 ENOG4105ED4 portal protein EAG14_14475 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EAG14_14490 ENOG4108Z18 K06886 hemoglobin EAG14_14495 ENOG4107RP9 extracellular solute-binding protein, family 3 EAG14_14500 ENOG4105EAD ABC transporter EAG14_14505 ENOG4105DRP amino acid AbC transporter EAG14_14515 ENOG4105CV6 ABC transporter, permease EAG14_14525 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EAG14_14545 ENOG4105QAX Iron-sulfur EAG14_14550 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EAG14_14580 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EAG14_14590 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit EAG14_14595 ENOG4105FCD Major Facilitator EAG14_14600 ENOG4105C5Q Transcriptional regulator EAG14_14620 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EAG14_14645 ENOG4108IYU L-aspartate oxidase EAG14_14650 ENOG4107RJX Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EAG14_14655 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase EAG14_14670 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EAG14_14690 ENOG4105DND Transcriptional regulator EAG14_14710 ENOG4105EB3 Histidine kinase EAG14_14720 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EAG14_14725 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EAG14_14740 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EAG14_14745 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EAG14_14755 ENOG4105C4R Atp-dependent dna helicase EAG14_14765 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) EAG14_14775 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EAG14_14840 ENOG4105C2C drug resistance transporter, Bcr CflA EAG14_14845 ENOG4105BZU Histidine kinase EAG14_14850 ENOG4105C1J atp-dependent rna helicase EAG14_14855 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) EAG14_14865 ENOG41090A4 Pterin carbinolamine dehydratase EAG14_14870 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EAG14_14875 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) EAG14_14885 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EAG14_14890 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) EAG14_14895 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EAG14_14900 ENOG4105K5M 30s ribosomal protein S16 EAG14_14915 ENOG4107QXV Phosphate transporter EAG14_14920 ENOG4107GRR phosphate transport regulator EAG14_14930 ENOG4108IV0 ABC, transporter EAG14_14935 ENOG4105C0Z ABC transporter EAG14_14940 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EAG14_14945 ENOG4105C32 Amino acid ABC transporter (Permease) EAG14_14950 ENOG4105D1H recombination factor protein RarA EAG14_14955 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) EAG14_14960 ENOG4105CNU cell division protein FtsK EAG14_14965 ENOG4107RYR Transcriptional regulator, Crp Fnr family EAG14_14970 ENOG4105C3M thioredoxin reductase EAG14_14975 ENOG4105KDC 50s ribosomal protein l28 EAG14_14980 ENOG4105W0E 50S ribosomal protein L33 EAG14_14985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EAG14_15015 ENOG4105E0F Histidine kinase EAG14_15020 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EAG14_15030 ENOG4108V3E phosphoribosylglycinamide formyltransferase EAG14_15035 ENOG4108YXG UPF0502 protein EAG14_15050 ENOG4105D2B acyl-CoA dehydrogenase EAG14_15055 ENOG4105C1G acyl-Coa dehydrogenase EAG14_15075 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EAG14_15080 ENOG4105BZU Histidine kinase EAG14_15085 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EAG14_15090 ENOG4105FFC UPF0187 protein EAG14_15100 ENOG4105DTN riboflavin biosynthesis protein ribF EAG14_15105 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EAG14_15110 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EAG14_15115 ENOG4105EAM Na Pi-cotransporter EAG14_15120 ENOG4105E2X shikimate dehydrogenase EAG14_15125 ENOG4105DHU Bile acid EAG14_15130 ENOG4108M0I Transcriptional regulator EAG14_15145 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EAG14_15150 ENOG4108IPJ Membrane EAG14_15155 ENOG4105BZU Histidine kinase EAG14_15165 ENOG4105CHR reductase EAG14_15195 ENOG4107QHF type ii secretion system protein e EAG14_15210 ENOG4105EYA deoxyribonuclease EAG14_15215 ENOG4105BZU Histidine kinase EAG14_15220 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EAG14_15225 ENOG4105D60 lipoprotein releasing system transmembrane protein EAG14_15235 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EAG14_15240 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_15245 ENOG4105DB7 PHP domain protein EAG14_15250 ENOG4107RTD sua5 ycio yrdc ywlc family protein EAG14_15255 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_15260 ENOG4108Z4T Peptidase M50 EAG14_15265 ENOG4105C31 Tryptophanyl-tRNA synthetase EAG14_15280 ENOG4108KXV response regulator EAG14_15295 ENOG4105CFF transcriptional regulator EAG14_15305 ENOG4105BZN citrate synthase EAG14_15310 ENOG4108I0Z Aconitate hydratase EAG14_15315 ENOG4105C7F AcnD-accessory protein PrpF EAG14_15330 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EAG14_15335 ENOG4105ETE Transcriptional regulator (LacI family EAG14_15350 ENOG4105D38 putrescine abc transporter EAG14_15355 ENOG4108IJ6 ABC transporter EAG14_15395 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EAG14_15400 ENOG4105C7B Threonine dehydratase EAG14_15405 ENOG4105CJW magnesium transporter EAG14_15410 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EAG14_15415 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase EAG14_15420 ENOG4105W5Q DNA repair protein (RadC EAG14_15425 ENOG4105C98 muts2 protein EAG14_15430 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic EAG14_15440 ENOG4105CSA Coproporphyrinogen iii oxidase EAG14_15445 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EAG14_15450 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EAG14_15465 ENOG4105DSJ YicC domain protein EAG14_15470 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EAG14_15475 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) EAG14_15480 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EAG14_15485 ENOG4108RRZ Transcription elongation factor GreB EAG14_15500 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EAG14_15505 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EAG14_15510 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EAG14_15515 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EAG14_15520 ENOG4105CEN a g-specific adenine glycosylase EAG14_15530 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EAG14_15545 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EAG14_15555 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EAG14_15560 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EAG14_15565 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EAG14_15570 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding EAG14_15575 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EAG14_15580 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EAG14_15590 ENOG4108JQ7 (ABC) transporter EAG14_15595 ENOG4105DEF Extracellular solute-binding protein, family 5 EAG14_15600 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EAG14_15630 ENOG4108RPX mosc domain containing protein EAG14_15635 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EAG14_15640 ENOG410829K Lysine exporter protein (Lyse ygga) EAG14_15665 ENOG4105EUJ GTP cyclohydrolase i EAG14_15670 ENOG4105DZQ phospholipase D Transphosphatidylase EAG14_15680 ENOG4108VYJ response regulator receiver protein EAG14_15695 ENOG4105C9M aspartyl-trna synthetase EAG14_15715 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) EAG14_15730 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EAG14_15755 ENOG4105QVC MOSC domain-containing protein EAG14_15760 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family EAG14_15765 ENOG4105T95 Thiol disulfide interChange protein EAG14_15775 ENOG4105E39 Enoyl-CoA hydratase EAG14_15795 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EAG14_15810 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) EAG14_15845 ENOG4105CYM Glutathione S-transferase EAG14_15855 ENOG4105C2M dna polymerase I EAG14_15865 ENOG4105CUV Homoserine Kinase EAG14_15920 ENOG4106H29 UPF0391 membrane protein EAG14_15925 ENOG4105ENE Histidine kinase EAG14_15945 ENOG4105CN1 protease EAG14_15950 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EAG14_15955 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) EAG14_15970 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EAG14_15975 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EAG14_15980 ENOG4105RQF LysR family Transcriptional regulator EAG14_15985 ENOG4105VFU Rna-binding protein EAG14_15995 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EAG14_16025 ENOG4105BZU Histidine kinase EAG14_16030 ENOG4105BZU Histidine kinase EAG14_16055 ENOG4105CNM Receptor EAG14_16060 ENOG4105R1U AraC Family Transcriptional Regulator EAG14_16065 ENOG4105DJ2 Major Facilitator Superfamily EAG14_16075 ENOG4108WUH Transcriptional regulator, TetR family EAG14_16110 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EAG14_16125 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EAG14_16150 ENOG4107QS1 Cytochrome C Oxidase, Subunit III EAG14_16160 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) EAG14_16170 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) EAG14_16180 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EAG14_16185 ENOG4105MJ2 Competence protein EAG14_16195 ENOG4105C32 Amino acid ABC transporter (Permease) EAG14_16205 ENOG4108IV0 ABC, transporter EAG14_16210 ENOG4105C0Z ABC transporter EAG14_16215 ENOG4105BZ1 (ABC) transporter EAG14_16220 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EAG14_16225 ENOG4105CC0 LysR family Transcriptional regulator EAG14_16245 ENOG410829K Lysine exporter protein (Lyse ygga) EAG14_16315 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EAG14_16320 ENOG4107WP9 Histidine kinase EAG14_16330 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EAG14_16340 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) EAG14_16355 ENOG4105CVM Molybdenum cofactor synthesis domain protein EAG14_16360 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b EAG14_16370 ENOG4105D6E homoserine dehydrogenase EAG14_16385 ENOG4105CHM Aminotransferase EAG14_16395 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EAG14_16400 ENOG4108IAB Phoh family EAG14_16410 ENOG4105CDU Replicative dna helicase EAG14_16415 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EAG14_16420 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EAG14_16430 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EAG14_16435 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EAG14_16440 ENOG4105CFG Acts as a chaperone (By similarity) EAG14_16445 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EAG14_16450 ENOG4105CY0 Metallo-Beta-Lactamase EAG14_16460 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EAG14_16470 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EAG14_16475 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EAG14_16480 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EAG14_16490 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EAG14_16495 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EAG14_16505 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EAG14_16510 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) EAG14_16515 ENOG4108VIA integral membrane protein EAG14_16555 ENOG4105C6Y Udp-glucose 6-dehydrogenase EAG14_16560 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EAG14_16570 ENOG4105CRK lysyL-tRNA synthetase EAG14_16580 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) EAG14_16585 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) EAG14_16590 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) EAG14_16595 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) EAG14_16600 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EAG14_16605 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EAG14_16615 ENOG4105C3F Signal peptidase i EAG14_16620 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EAG14_16625 ENOG4105C0H protease EAG14_16640 ENOG4105EMN RNA polymerase sigma factor EAG14_16650 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EAG14_16655 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EAG14_16660 ENOG4105CHR reductase EAG14_16665 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EAG14_16670 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EAG14_16675 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EAG14_16680 ENOG4105VGS 50s ribosomal protein l32 EAG14_16685 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein EAG14_16690 ENOG4108UHJ MAF-like protein EAG14_16695 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EAG14_16700 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EAG14_16715 ENOG4105EI2 Pseudouridine synthase EAG14_16725 ENOG4105D1Q UPF0246 protein EAG14_16735 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EAG14_16740 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor EAG14_16745 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor EAG14_16750 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EAG14_16780 ENOG4105CHM Aminotransferase EAG14_16795 ENOG4105C26 Dehydrogenase EAG14_16800 ENOG4105ETT transcriptional Regulator, LysR family EAG14_16825 ENOG4107HP6 Transcriptional regulator EAG14_16830 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EAG14_16835 ENOG4105F38 ABC transporter, permease EAG14_16840 ENOG4105D38 putrescine abc transporter EAG14_16855 ENOG41080HI glycine oxidase EAG14_16880 ENOG4105BZU Histidine kinase EAG14_16890 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_16900 ENOG4105DU6 RNA polymerase EAG14_16910 ENOG4105DMF Dehydrogenase EAG14_16915 ENOG4105BZU Histidine kinase EAG14_16920 ENOG4105BZ4 penicillin-binding protein EAG14_16930 ENOG4105DN3 alpha-2-macroglobulin domain protein EAG14_16950 ENOG4105CH7 arginosuccinase EAG14_16955 ENOG4108HRK Histidine kinase EAG14_16960 ENOG4108NEV two component transcriptional regulator, LytTR family EAG14_16970 ENOG4105CNM Receptor EAG14_16985 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component EAG14_16990 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EAG14_17000 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_17015 ENOG4105CD3 dihydroorotase EAG14_17020 ENOG4105CXT aspartate transcarbamylase EAG14_17025 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) EAG14_17030 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EAG14_17035 ENOG4108UJU UPF0301 protein EAG14_17045 ENOG4105CBS Chea signal transduction histidine kinase EAG14_17055 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_17060 ENOG4108V3W Chemotaxis protein, CheW EAG14_17065 ENOG4105M3Z response regulator EAG14_17070 ENOG4108UNF response regulator EAG14_17075 ENOG4105VCQ rubredoxin EAG14_17085 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EAG14_17095 ENOG4107HP6 Transcriptional regulator EAG14_17100 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase EAG14_17105 ENOG4105W2Z cytochrome C, class I EAG14_17110 ENOG4105DC1 bifunctional purine biosynthesis protein purh EAG14_17115 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) EAG14_17120 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EAG14_17135 ENOG4105BZU Histidine kinase EAG14_17140 ENOG4105C3G gtp-binding protein EAG14_17145 ENOG4108JQ1 Dehydrogenase EAG14_17150 ENOG4105BZ7 extracellular solute-binding protein family 1 EAG14_17155 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component EAG14_17165 ENOG4108IJ9 (ABC) transporter EAG14_17175 ENOG4107T6V glycerophosphoryl diester phosphodiesterase EAG14_17190 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EAG14_17195 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EAG14_17200 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EAG14_17215 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EAG14_17220 ENOG4105C37 (CBS) domain EAG14_17225 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division EAG14_17230 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EAG14_17235 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EAG14_17240 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EAG14_17245 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EAG14_17250 ENOG4105K46 50S ribosomal protein l27 EAG14_17255 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EAG14_17260 ENOG4105EAH synthase EAG14_17265 ENOG4107QHF type ii secretion system protein e EAG14_17275 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) EAG14_17280 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EAG14_17285 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) EAG14_17290 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) EAG14_17295 ENOG4105M6F mutator MutT protein EAG14_17305 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EAG14_17310 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EAG14_17315 ENOG4105DR5 peptidase EAG14_17330 ENOG4105KB2 stringent starvation protein b EAG14_17335 ENOG4107MKT Stringent starvation protein a EAG14_17340 ENOG4105EIX cytochrome c1 EAG14_17345 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EAG14_17360 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EAG14_17365 ENOG4107QNR UPF0135 protein EAG14_17370 ENOG4105C0H protease EAG14_17375 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EAG14_17380 ENOG4107Z6S Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) EAG14_17385 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EAG14_17390 ENOG4107YU2 histidine triad (hIT) protein EAG14_17405 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase EAG14_17410 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EAG14_17415 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EAG14_17420 ENOG4105CMR udp-glucose 4-epimerase EAG14_17485 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EAG14_17490 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EAG14_17495 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EAG14_17500 ENOG4105CIH Imidazole acetol-phosphate transaminase EAG14_17515 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) EAG14_17520 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) EAG14_17525 ENOG4105CRE cytochrome C EAG14_17540 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) EAG14_17550 ENOG4105D1S lipid A biosynthesis EAG14_17560 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EAG14_17590 ENOG4107RH7 Nicotinate phosphoribosyltransferase EAG14_17605 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_17615 ENOG4105CE7 Amidase, hydantoinase carbamoylase family EAG14_17620 ENOG4105CD3 dihydroorotase EAG14_17625 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EAG14_17630 ENOG4107SJI Dehydrogenase EAG14_17635 ENOG4105BZ8 glutamate synthase EAG14_17640 ENOG4108R86 Transcriptional regulator EAG14_17655 ENOG4107TSN permease EAG14_17660 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase EAG14_17675 ENOG4105C11 sulfate adenylyltransferase), subunit 2 EAG14_17725 ENOG4108IUS Transketolase EAG14_17730 ENOG4108HHA Transketolase EAG14_17735 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EAG14_17740 ENOG4105FAW cDP-glucose 4,6-dehydratase EAG14_17745 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EAG14_17750 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein EAG14_17755 ENOG4105EY8 ABC transporter EAG14_17765 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase EAG14_17795 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EAG14_17800 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EAG14_17810 ENOG4105VBA Cytochrome EAG14_17825 ENOG4105XJC Two component transcriptional regulator (Winged helix family EAG14_17830 ENOG4105DHQ Histidine kinase EAG14_17835 ENOG4108UHU Aldolase EAG14_17860 ENOG4107QP8 phosphohexose isomerase EAG14_17870 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase EAG14_17875 ENOG4105CHC glucokinase (EC 2.7.1.2) EAG14_17880 ENOG4108IJ9 (ABC) transporter EAG14_17885 ENOG4105DRS transport system, permease EAG14_17905 ENOG4105XJC Two component transcriptional regulator (Winged helix family EAG14_17910 ENOG4105DHQ Histidine kinase EAG14_17915 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EAG14_17930 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EAG14_17950 ENOG4105CGH 5'-nucleotidase EAG14_17955 ENOG4108JQ7 (ABC) transporter EAG14_17960 ENOG4105C3U ABC transporter EAG14_17965 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EAG14_17970 ENOG4105DEF Extracellular solute-binding protein, family 5 EAG14_17975 ENOG4105CH2 amidohydrolase EAG14_17985 ENOG4105DEF Extracellular solute-binding protein, family 5 EAG14_17995 ENOG4108Z9W Outer membrane porin EAG14_18000 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) EAG14_18005 ENOG4108UKZ OsmC family EAG14_18010 ENOG4105C7B Threonine dehydratase EAG14_18015 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) EAG14_18030 ENOG4108VAU general secretion pathway protein G EAG14_18045 ENOG4108WWZ General secretion pathway protein J EAG14_18070 ENOG4105GVR general secretion pathway protein D EAG14_18075 ENOG4107QHF type ii secretion system protein e EAG14_18085 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_18090 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EAG14_18095 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EAG14_18100 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_18105 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EAG14_18110 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EAG14_18115 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) EAG14_18120 ENOG4105CPF Cell wall formation (By similarity) EAG14_18125 ENOG4105DFU Cell wall formation (By similarity) EAG14_18130 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EAG14_18135 ENOG4105CNI cell division protein FtsW EAG14_18140 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EAG14_18145 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EAG14_18150 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) EAG14_18155 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EAG14_18165 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) EAG14_18170 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EAG14_18175 ENOG4108V6E Cell division protein mraZ EAG14_18180 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) EAG14_18185 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) EAG14_18195 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters EAG14_18200 ENOG4105CKI cobalamin synthesis protein EAG14_18205 ENOG4105DR4 Methyltransferase EAG14_18210 ENOG4108V3W Chemotaxis protein, CheW EAG14_18225 ENOG4105C3F Signal peptidase i EAG14_18230 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EAG14_18240 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EAG14_18245 ENOG4105CYM Glutathione S-transferase EAG14_18250 ENOG4105HEI LysR family (Transcriptional regulator EAG14_18255 ENOG4105F27 Major Facilitator EAG14_18265 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EAG14_18275 ENOG4108M3P Membrane EAG14_18295 ENOG4105CYB regulatoR EAG14_18315 ENOG4105E0Y RtcB Protein EAG14_18320 ENOG410756H nucleotidyltransferase EAG14_18325 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP EAG14_18335 ENOG4105DZ0 fad dependent oxidoreductase EAG14_18340 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_18350 ENOG4105JN3 extra-cytoplasmic solute receptor family protein EAG14_18355 ENOG4105C10 Electron transfer flavoprotein EAG14_18360 ENOG4105BZJ Electron transfer flavoprotein EAG14_18365 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EAG14_18370 ENOG4105C1G acyl-Coa dehydrogenase EAG14_18375 ENOG4105CC9 acyl-Coa dehydrogenase EAG14_18380 ENOG4105CHU acetyl-coa acetyltransferase EAG14_18385 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EAG14_18390 ENOG4105EXG Transcriptional regulator EAG14_18395 ENOG4105D0M Protease HtpX homolog EAG14_18405 ENOG4105EKE dihydroorotase EAG14_18430 ENOG4105CDA abc transporter atp-binding protein EAG14_18435 ENOG4105DRP amino acid AbC transporter EAG14_18440 ENOG4105EAD ABC transporter EAG14_18445 ENOG4107RP9 extracellular solute-binding protein, family 3 EAG14_18450 ENOG4107RP9 extracellular solute-binding protein, family 3 EAG14_18455 ENOG4107YNJ LysR family Transcriptional regulator EAG14_18465 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EAG14_18470 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EAG14_18475 ENOG4105DAA L-lactate EAG14_18480 ENOG41073TP transcriptional regulator EAG14_18490 ENOG4105CXG d-lactate dehydrogenase EAG14_18500 ENOG4108JQ1 Dehydrogenase EAG14_18505 ENOG4108JJ7 ABC transporter EAG14_18510 ENOG4105NAU thioesterase Superfamily protein EAG14_18520 ENOG4108VUY thioesterase Superfamily protein EAG14_18525 ENOG4105E39 Enoyl-CoA hydratase EAG14_18540 ENOG4105CHU acetyl-coa acetyltransferase EAG14_18560 ENOG4105CSU acyl-Coa dehydrogenase EAG14_18570 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) EAG14_18575 ENOG4105DHQ Histidine kinase EAG14_18580 ENOG4105XJC Two component transcriptional regulator (Winged helix family EAG14_18585 ENOG4105CAS nag kinase EAG14_18600 ENOG4108VKQ nitriC oxide reductase EAG14_18605 ENOG4105DSQ Nitric oxide reductase EAG14_18650 ENOG4105EY8 ABC transporter EAG14_18660 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EAG14_18710 ENOG4108VAU general secretion pathway protein G EAG14_18715 ENOG4105D7Q type ii secretion system EAG14_18720 ENOG4107QHF type ii secretion system protein e EAG14_18730 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase EAG14_18740 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EAG14_18765 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) EAG14_18770 ENOG4109066 lysm domain bon superfamily protein EAG14_18790 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase EAG14_18795 ENOG4105C38 Glycyl-tRNA synthetase beta subunit EAG14_18800 ENOG41061CK Antibiotic biosynthesis monooxygenase EAG14_18805 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit EAG14_18815 ENOG41080UQ Transcriptional regulator EAG14_18830 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) EAG14_18835 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EAG14_18840 ENOG4108JU5 Magnesium and cobalt efflux protein EAG14_18860 ENOG4105DVE abc transporter atp-binding protein EAG14_18865 ENOG4105J0Q Transcriptional regulator EAG14_18880 ENOG4105MIR Phenylalanine 4-monooxygenase EAG14_18890 ENOG4105CEY Amp-dependent synthetase and ligase EAG14_18895 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EAG14_18900 ENOG4105C2J ABC transporter EAG14_18905 ENOG4105CNN ABC, transporter EAG14_18910 ENOG4105ETE Transcriptional regulator (LacI family EAG14_18915 ENOG4108RVA ribokinase EAG14_18920 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EAG14_18935 ENOG4105E4C Lytic transglycosylase catalytic EAG14_18940 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EAG14_18960 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EAG14_18970 ENOG4108ZJD Protein of unknown function (DUF1109) EAG14_18975 ENOG4105NCT RNA Polymerase EAG14_18985 ENOG4105E18 UPF0276 protein EAG14_19015 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EAG14_19065 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) EAG14_19095 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EAG14_19100 ENOG4105C9A Phoh family EAG14_19105 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EAG14_19110 ENOG4105CSH Transporter EAG14_19115 ENOG4105E2S oxidase) subunit II EAG14_19120 ENOG4105BZ9 Cytochrome C oxidase, subunit I EAG14_19125 ENOG4105CCU oxidase (Subunit III) EAG14_19130 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) EAG14_19140 ENOG4105TX3 Histidine kinase EAG14_19150 ENOG4105EJ9 Membrane EAG14_19155 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EAG14_19175 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_19185 ENOG4105C1J atp-dependent rna helicase EAG14_19195 ENOG4105FYV Amp nucleosidase EAG14_19200 ENOG4105BZU Histidine kinase EAG14_19205 ENOG4105CJ1 ABC, transporter EAG14_19210 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR EAG14_19230 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EAG14_19240 ENOG4105ETX regulatoR EAG14_19255 ENOG4105K56 Transcriptional regulator EAG14_19260 ENOG4108ZHJ Organic hydroperoxide resistance protein EAG14_19270 ENOG4105D9P serine threonine protein kinase EAG14_19280 ENOG4105E27 serine threonine protein kinase EAG14_19285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EAG14_19300 ENOG4105BZU Histidine kinase EAG14_19320 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EAG14_19330 ENOG4105FE9 pseudouridine synthase EAG14_19340 ENOG4105BZU Histidine kinase EAG14_19355 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_19360 ENOG4105IJJ transcriptional regulator, crp fnr family EAG14_19380 ENOG4105C0Z ABC transporter EAG14_19385 ENOG4105C32 Amino acid ABC transporter (Permease) EAG14_19390 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane EAG14_19400 ENOG4108IV0 ABC, transporter EAG14_19405 ENOG4105DZS Phenylacetate-CoA ligase EAG14_19425 ENOG4105FDR Membrane EAG14_19445 ENOG4105EXW epimerase dehydratase EAG14_19470 ENOG4105MSY salicylate hydroxylase EAG14_19480 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EAG14_19505 ENOG4108R3E Dna-3-methyladenine glycosylase i EAG14_19520 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EAG14_19525 ENOG4105F2V VRR-NUC domain-containing protein EAG14_19545 ENOG4105CH2 amidohydrolase EAG14_19570 ENOG4108WC5 Alpha Beta Hydrolase Fold protein EAG14_19615 ENOG4105NSG hemerythrin hhe cation binding domain protein EAG14_19635 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EAG14_19650 ENOG4105D0D Nitrate reductase 2, gamma subunit EAG14_19655 ENOG4105R3A Nitrate reductase EAG14_19660 ENOG4108IUE nitrate reductase beta subunit EAG14_19670 ENOG4105DQQ Major facilitator superfamily MFS_1 EAG14_19680 ENOG4105WH1 Two component transcriptional regulator luxr family EAG14_19685 ENOG4105BZU Histidine kinase EAG14_19700 ENOG4108PZW LysR family Transcriptional regulator EAG14_19715 ENOG4105CQB FAD linked oxidase domain protein EAG14_19720 ENOG4105VAW lrga family EAG14_19725 ENOG41067MG lrgb family EAG14_19730 ENOG4106BRA Membrane EAG14_19745 ENOG4105DFA alanine racemase domain protein EAG14_19750 ENOG4105CZX twitching motility protein EAG14_19755 ENOG4105IJJ transcriptional regulator, crp fnr family EAG14_19760 ENOG4105CZX twitching motility protein EAG14_19765 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EAG14_19770 ENOG4105W4M Transport-associated protein EAG14_19775 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) EAG14_19780 ENOG41082RQ UPF0102 protein EAG14_19785 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EAG14_19790 ENOG4105R8A Heat shock protein EAG14_19845 ENOG4105ZTC transcriptional activator, Ogr delta EAG14_19880 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EAG14_19890 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EAG14_19895 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EAG14_19900 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EAG14_19905 ENOG4108VZM 50s ribosomal protein L10 EAG14_19910 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) EAG14_19915 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EAG14_19920 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EAG14_19925 ENOG4105PM1 preprotein translocase subunit SecE EAG14_19935 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EAG14_19965 ENOG4105C1P efflux transporter, rnd family, mfp subunit EAG14_19970 ENOG4105BZS acriflavin resistance protein EAG14_19975 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EAG14_20000 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EAG14_20005 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EAG14_20010 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EAG14_20015 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EAG14_20020 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EAG14_20025 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EAG14_20030 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EAG14_20035 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) EAG14_20045 ENOG4108Z43 UPF0250 protein EAG14_20050 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EAG14_20055 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EAG14_20060 ENOG4105FTV AraC Family Transcriptional Regulator EAG14_20075 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EAG14_20080 ENOG41080Z8 PHOSPHOCARRIER protein EAG14_20100 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EAG14_20115 ENOG4105KY5 gCN5-related N-acetyltransferase EAG14_20125 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EAG14_20130 ENOG41084PQ 50s ribosomal protein l29 EAG14_20135 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EAG14_20140 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EAG14_20145 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EAG14_20150 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EAG14_20155 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EAG14_20160 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EAG14_20165 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EAG14_20170 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EAG14_20175 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) EAG14_20180 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EAG14_20185 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EAG14_20190 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EAG14_20195 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EAG14_20200 ENOG4105DZ1 carboxypeptidase EAG14_20205 ENOG4105DHZ alpha beta EAG14_20220 ENOG4108YXA Membrane EAG14_20225 ENOG4105D52 delta-aminolevulinic acid dehydratase EAG14_20230 ENOG4105D7N magnesium and cobalt transport protein CorA EAG14_20235 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EAG14_20240 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_20260 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EAG14_20265 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EAG14_20270 ENOG4105E3W Two component transcriptional regulator (Winged helix family EAG14_20275 ENOG4105EB3 Histidine kinase EAG14_20280 ENOG4105CT7 inner membrane cred family protein EAG14_20300 ENOG4105VDW Csbd family EAG14_20330 ENOG4108PZW LysR family Transcriptional regulator EAG14_20355 ENOG4105DHJ ABC, transporter EAG14_20385 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein EAG14_20390 ENOG4105E5Q amino acid AbC transporter EAG14_20415 ENOG4105CJN penicillin-binding protein EAG14_20430 ENOG4105DFF Rod shape-determining protein mreb EAG14_20435 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EAG14_20440 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EAG14_20445 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EAG14_20455 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EAG14_20460 ENOG4105CGK Exodeoxyribonuclease III EAG14_20465 ENOG4105C5X domain protein EAG14_20470 ENOG4108IU3 tonb-dependent siderophore receptor EAG14_20480 ENOG4107QPK )-transporter EAG14_20485 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EAG14_20510 ENOG4105BZU Histidine kinase EAG14_20520 ENOG4105EYM Major Facilitator superfamily EAG14_20525 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EAG14_20535 ENOG4105CBP Major Facilitator EAG14_20550 ENOG410650X lipopolysaccharide core region biosynthetic process EAG14_20570 ENOG4107T8Q Glycosyl transferase (Group 1 EAG14_20580 ENOG4105CM2 brancheD-chain amino acid aminotransferase EAG14_20590 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EAG14_20600 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EAG14_20605 ENOG4108RXX maleylacetoacetate isomerase EAG14_20610 ENOG4105DEF Extracellular solute-binding protein, family 5 EAG14_20660 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EAG14_20665 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) EAG14_20675 ENOG4108V06 Glutathione peroxidase EAG14_20695 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) EAG14_20700 ENOG4105DHT Metal Dependent Phosphohydrolase EAG14_20705 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EAG14_20715 ENOG4105EU8 FAD linked oxidase domain protein EAG14_20720 ENOG4105BZU Histidine kinase EAG14_20725 ENOG4108YZA Nitrogen regulatory protein pii EAG14_20745 ENOG4105DZR Type I site-specific deoxyribonuclease EAG14_20780 ENOG4105CHR reductase EAG14_20785 ENOG4105CBN LysR family transcriptional regulator EAG14_20805 ENOG4105E9F Enoyl-CoA hydratase EAG14_20845 ENOG4105C58 cytochrome c oxidase accessory protein ccog EAG14_20875 ENOG4108IV0 ABC, transporter EAG14_20880 ENOG4105C0Z ABC transporter EAG14_20885 ENOG4105C32 Amino acid ABC transporter (Permease) EAG14_20890 ENOG41083Z3 extracellular ligand-binding receptor EAG14_20910 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EAG14_20955 ENOG4108UQ8 endoribonuclease L-psp EAG14_20975 ENOG4105C3R Methionine synthase EAG14_20990 ENOG4108IV0 ABC, transporter EAG14_20995 ENOG4105C0Z ABC transporter EAG14_21005 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EAG14_21015 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein EAG14_21020 ENOG4105BZU Histidine kinase EAG14_21025 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EAG14_21045 ENOG4105CSR polyphosphate kinase 2 EAG14_21065 ENOG4105D82 Glutamate dehydrogenase EAG14_21100 ENOG4105CFP Peptidase U32 EAG14_21105 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) EAG14_21110 ENOG4105C3R Methionine synthase EAG14_21125 ENOG4105C9U ATP-dependent DNA helicase RecQ EAG14_21135 ENOG4105E9K Isocitrate dehydrogenase EAG14_21155 ENOG4108Q5F Tetr family transcriptional regulator EAG14_21165 ENOG4105C7B Threonine dehydratase EAG14_21170 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EAG14_21175 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) EAG14_21210 ENOG4105MWK D-amino acid dehydrogenase, small subunit EAG14_21245 ENOG4105EM2 membrane EAG14_21250 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) EAG14_21255 ENOG4107QMS site-determining protein EAG14_21260 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) EAG14_21275 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EAG14_21280 ENOG4105CEY Amp-dependent synthetase and ligase EAG14_21290 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EAG14_21305 ENOG4108K0D peptidase, M48 EAG14_21310 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase EAG14_21330 ENOG4105C2W permease EAG14_21350 ENOG4105KA0 thioesterase Superfamily protein EAG14_21380 ENOG4108WBT adenosyltransferase EAG14_21395 ENOG4105CDA abc transporter atp-binding protein EAG14_21400 ENOG4105E5Q amino acid AbC transporter EAG14_21425 ENOG4105CQB FAD linked oxidase domain protein EAG14_21460 ENOG4108ZHR arsR family transcriptional regulator EAG14_21470 ENOG4105DEF Extracellular solute-binding protein, family 5 EAG14_21525 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EAG14_21530 ENOG4105DJY efflux transporter, rnd family, mfp subunit EAG14_21565 ENOG4105EW6 flavin reductase domain protein, FMN-binding EAG14_21585 ENOG4105E89 ABC transporter EAG14_21600 ENOG4108J5H Homocysteine s-methyltransferase EAG14_21645 ENOG4108TN6 type iii secretion EAG14_21690 ENOG4107Y59 type iii secretion EAG14_21720 ENOG4105E4C Lytic transglycosylase catalytic EAG14_21745 ENOG4105NZG Ferredoxin EAG14_21750 ENOG4105E4R Precorrin-3B C17-methyltransferase EAG14_21765 ENOG4108P62 biosynthesis protein (CbiG) EAG14_21775 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase EAG14_21780 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) EAG14_21785 ENOG41081F0 Precorrin-8x methylmutase EAG14_21790 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EAG14_21795 ENOG4105CIA precorrin-4 C(11)-methyltransferase EAG14_21840 ENOG4105FA0 parb-like partition protein EAG14_21860 ENOG4107QJE Chromosome Partitioning Protein EAG14_21870 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) EAG14_21875 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EAG14_21885 ENOG4105KRS Proteinase inhibitor EAG14_21890 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_21895 ENOG4108KPJ rna polymerase sigma factor EAG14_21900 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EAG14_21905 ENOG4105MP9 class II Aldolase EAG14_21910 ENOG4108K3A Glutathione S-transferase EAG14_21915 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EAG14_21925 ENOG4105C8Q Methyl-accepting chemotaxis EAG14_21930 ENOG4105C59 p-type ATPase EAG14_21950 ENOG4105DH7 May be involved in recombination (By similarity) EAG14_21960 ENOG4105BZU Histidine kinase EAG14_21965 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EAG14_21970 ENOG4105K4H Nlp p60 protein EAG14_21975 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EAG14_21985 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EAG14_21995 ENOG4107VAM peptidase, m28 EAG14_22000 ENOG4108UVJ appr-1-p processing domain protein EAG14_22005 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EAG14_22010 ENOG4105DVT helicase EAG14_22025 ENOG410620I Diguanylate cyclase EAG14_22030 ENOG4108Z0R Transferase EAG14_22040 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) EAG14_22045 ENOG410630P Transcriptional regulator EAG14_22070 ENOG4105D6E homoserine dehydrogenase EAG14_22120 ENOG4105FA0 parb-like partition protein EAG14_22160 ENOG4107QTH restriction modification system DNA specificity domain EAG14_22180 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EAG14_22185 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EAG14_22190 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EAG14_22195 ENOG4105VG0 50S ribosomal protein l34 EAG14_22200 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EAG14_22205 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EAG14_22210 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EAG14_22215 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EAG14_22235 ENOG4105EVZ LysR family transcriptional regulator EAG14_22240 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EAG14_22250 ENOG4105C26 Dehydrogenase EAG14_22255 ENOG4105DEF Extracellular solute-binding protein, family 5 EAG14_22265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EAG14_22280 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EAG14_22290 ENOG4105C6K Malic enzyme EAG14_22305 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EAG14_22310 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) EAG14_22315 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) EAG14_22320 ENOG4105EHM Aminoglycoside phosphotransferase EAG14_22325 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EAG14_22330 ENOG4105BZU Histidine kinase EAG14_22375 ENOG4105EYW Ion transport protein EAG14_22380 ENOG4108T5G Adenylate EAG14_22425 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EAG14_22430 ENOG4108004 Modulates RecA activity (By similarity) EAG14_22435 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EAG14_22440 ENOG4105CMV Succinyl-CoA synthetase subunit beta EAG14_22445 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EAG14_22455 ENOG4108ZF3 Phosphatase EAG14_22465 ENOG4105F8J Adenylate Guanylate cyclase EAG14_22475 ENOG4105KHS type IV fimbrial pilin protein EAG14_22480 ENOG4105KHS type IV fimbrial pilin protein EAG14_22485 ENOG4105YWY EAG14_22495 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EAG14_22500 ENOG4105ERG peptidase m48, ste24p EAG14_22505 ENOG41086DT Membrane protein of unknown function EAG14_22520 ENOG4108ZCF integral membrane protein