locus-tag	class	description
C380_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C380_00030	COG0318	PFAM AMP-dependent synthetase and ligase
C380_00055	COG0745	RESPONSE REGULATOR receiver
C380_00060	COG2205	protein histidine kinase activity
C380_00075	COG1254	Belongs to the acylphosphatase family
C380_00115	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C380_00120	COG2199	diguanylate cyclase activity
C380_00120	COG2203	Gaf domain
C380_00150	COG1199	ATP-dependent helicase activity
C380_00155	COG2824	Alkylphosphonate utilization operon protein PhnA
C380_00180	COG2176	DNA-directed DNA polymerase activity
C380_00205	COG4941	Belongs to the sigma-70 factor family
C380_00225	COG3795	YCII-related domain
C380_00230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C380_00235	COG0791	NLP P60 protein
C380_00245	COG3384	dioxygenase
C380_00255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_00270	COG0583	DNA-binding transcription factor activity
C380_00275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C380_00300	COG2974	May be involved in recombination
C380_00305	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C380_00310	COG1741	Belongs to the pirin family
C380_00320	COG1024	Enoyl-CoA hydratase
C380_00325	COG1022	Amp-dependent synthetase and ligase
C380_00365	COG3550	peptidyl-serine autophosphorylation
C380_00395	COG0789	Transcriptional regulator
C380_00405	COG2217	Heavy metal translocating P-type atpase
C380_00410	COG0840	transmembrane signaling receptor activity
C380_00420	COG1902	pentaerythritol trinitrate reductase activity
C380_00430	COG0625	glutathione transferase activity
C380_00440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C380_00445	COG1595	DNA-templated transcription, initiation
C380_00470	COG0357	Ribosomal RNA small subunit methyltransferase G
C380_00480	COG1192	Involved in chromosome partitioning
C380_00500	COG1475	DNA binding
C380_00585	COG1201	RNA secondary structure unwinding
C380_00590	COG1793	dna ligase
C380_00595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C380_00595	COG1793	dna ligase
C380_00605	COG4166	transmembrane transport
C380_00610	COG1742	UPF0060 membrane protein
C380_00615	COG0640	Transcriptional regulator
C380_00640	COG0277	FAD linked oxidase domain protein
C380_00680	COG0765	amino acid transport
C380_00685	COG0765	amino acid transport
C380_00690	COG1126	abc transporter atp-binding protein
C380_00705	COG2096	Adenosyltransferase
C380_00710	COG2050	protein possibly involved in aromatic compounds catabolism
C380_00715	COG0683	leucine binding
C380_00730	COG2233	PERMEase
C380_00745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C380_00765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C380_00770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C380_00780	COG0318	PFAM AMP-dependent synthetase and ligase
C380_00785	COG1183	phosphatidylcholine synthase activity
C380_00790	COG0384	phenazine biosynthesis protein PhzF
C380_00795	COG0583	DNA-binding transcription factor activity
C380_00800	COG0745	RESPONSE REGULATOR receiver
C380_00800	COG3706	GGDEF domain
C380_00810	COG0850	regulation of cytokinetic process
C380_00820	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C380_00825	COG1289	transmembrane transporter activity
C380_00835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C380_00845	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C380_00855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C380_00870	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C380_00875	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C380_00900	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C380_00905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C380_00915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C380_00920	COG3604	Transcriptional regulator
C380_00925	COG3256	nitric oxide reductase
C380_00955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_00960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C380_00965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_00970	COG0277	FAD linked oxidase domain protein
C380_00985	COG0583	DNA-binding transcription factor activity
C380_00995	COG0037	tRNA processing
C380_01020	COG2211	Major facilitator Superfamily
C380_01030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C380_01045	COG2326	polyphosphate kinase activity
C380_01075	COG1410	methionine synthase
C380_01075	COG0646	methionine synthase
C380_01080	COG0251	oxidation-reduction process
C380_01090	COG3706	GGDEF domain
C380_01090	COG0745	RESPONSE REGULATOR receiver
C380_01095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C380_01115	COG1295	ribonuclease BN
C380_01130	COG1309	transcriptional regulator
C380_01175	COG0411	ABC transporter
C380_01190	COG2080	2 iron, 2 sulfur cluster binding
C380_01195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C380_01195	COG2010	Cytochrome c
C380_01220	COG1522	sequence-specific DNA binding
C380_01255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C380_01265	COG1960	acyl-CoA dehydrogenase activity
C380_01285	COG1024	Enoyl-CoA hydratase
C380_01320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_01350	COG1538	Outer membrane efflux protein
C380_01355	COG0606	chelatase, subunit chli
C380_01370	COG0004	ammonium transporteR
C380_01375	COG0277	FAD linked oxidase domain protein
C380_01385	COG0247	lactate metabolic process
C380_01390	COG1278	Cold shock
C380_01395	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C380_01415	COG3279	Response regulator of the LytR AlgR family
C380_01430	COG0386	Belongs to the glutathione peroxidase family
C380_01440	COG0477	Major facilitator Superfamily
C380_01445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C380_01475	COG0747	negative chemotaxis
C380_01480	COG0625	glutathione transferase activity
C380_01485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C380_01515	COG0463	Glycosyl transferase, family 2
C380_01520	COG3307	-O-antigen
C380_01540	COG0477	Major facilitator Superfamily
C380_01545	COG2205	protein histidine kinase activity
C380_01550	COG0745	RESPONSE REGULATOR receiver
C380_01555	COG2211	Major facilitator Superfamily
C380_01560	COG4783	chaperone-mediated protein folding
C380_01565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C380_01595	COG0708	Exodeoxyribonuclease III
C380_01600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C380_01610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C380_01615	COG0154	amidase activity
C380_01620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C380_01625	COG1077	Cell shape determining protein MreB Mrl
C380_01630	COG1792	Involved in formation and maintenance of cell shape
C380_01635	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C380_01640	COG0768	penicillin binding
C380_01655	COG0765	amino acid transport
C380_01660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C380_01670	COG0004	ammonium transporteR
C380_01690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C380_01695	COG1127	ABC transporter
C380_01725	COG3237	CsbD-like
C380_01740	COG3706	GGDEF domain
C380_01750	COG4452	Inner membrane protein CreD
C380_01760	COG2205	protein histidine kinase activity
C380_01765	COG0745	RESPONSE REGULATOR receiver
C380_01770	COG2095	MarC family integral membrane protein
C380_01775	COG1028	Short-chain dehydrogenase reductase Sdr
C380_01780	COG0412	Dienelactone hydrolase
C380_01790	COG0598	Magnesium transport protein CorA
C380_01815	COG2945	thiolester hydrolase activity
C380_01820	COG1686	Belongs to the peptidase S11 family
C380_01825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C380_01830	COG0049	tRNA binding
C380_01835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C380_01840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C380_01845	COG0051	transcription antitermination factor activity, RNA binding
C380_01850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C380_01855	COG0088	Forms part of the polypeptide exit tunnel
C380_01860	COG0089	rRNA binding
C380_01865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C380_01870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C380_01875	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C380_01880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C380_01885	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C380_01890	COG0255	Belongs to the universal ribosomal protein uL29 family
C380_01895	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C380_01900	COG0678	peroxiredoxin activity
C380_01920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C380_01940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C380_01945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C380_01960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C380_01965	COG0321	lipoyl(octanoyl) transferase activity
C380_01970	COG2921	Belongs to the UPF0250 family
C380_01980	COG0356	it plays a direct role in the translocation of protons across the membrane
C380_01990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C380_01995	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C380_02000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C380_02005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C380_02010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C380_02015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C380_02060	COG3245	cytochrome
C380_02065	COG1538	Outer membrane efflux protein
C380_02070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C380_02075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_02085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C380_02090	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C380_02100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C380_02105	COG0081	regulation of translation
C380_02110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C380_02115	COG0222	ribosome binding
C380_02120	COG0085	RNA polymerase activity
C380_02125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C380_02135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C380_02135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C380_02145	COG5000	phosphorelay sensor kinase activity
C380_02150	COG2204	response regulator
C380_02175	COG0582	viral genome integration into host DNA
C380_02190	COG0443	Heat shock 70 kDa protein
C380_02200	COG0792	nuclease activity
C380_02205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C380_02210	COG2823	Periplasmic or secreted lipoprotein
C380_02215	COG2084	Dehydrogenase
C380_02225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C380_02235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C380_02255	COG0318	PFAM AMP-dependent synthetase and ligase
C380_02260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C380_02265	COG1280	lysine exporter protein (LysE YggA)
C380_02280	COG2733	membrane
C380_02285	COG1346	cytolysis
C380_02290	COG1380	Effector of murein hydrolase LrgA
C380_02295	COG0277	FAD linked oxidase domain protein
C380_02300	COG0583	DNA-binding transcription factor activity
C380_02320	COG3850	Histidine kinase
C380_02325	COG2197	response regulator
C380_02335	COG2223	nitrite transmembrane transporter activity
C380_02340	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C380_02345	COG1140	nitrate reductase beta subunit
C380_02350	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C380_02355	COG2181	nitrate reductase activity
C380_02360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C380_02365	COG0288	reversible hydration of carbon dioxide
C380_02385	COG3945	hemerythrin HHE cation binding domain
C380_02430	COG0583	DNA-binding transcription factor activity
C380_02435	COG1979	alcohol dehydrogenase
C380_02450	COG0243	molybdopterin cofactor binding
C380_02465	COG1473	amidohydrolase
C380_02490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C380_02500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C380_02505	COG2423	ornithine cyclodeaminase activity
C380_02525	COG2818	Glycosylase
C380_02540	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C380_02545	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C380_02550	COG1609	Transcriptional regulator
C380_02555	COG3624	Phosphonate C-P lyase system protein PhnG
C380_02560	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C380_02565	COG3626	phosphonate metabolism
C380_02570	COG3627	carbon phosphorus lyase activity
C380_02580	COG4107	phosphonate C-P lyase system protein PhnK
C380_02585	COG4778	phosphonate C-P lyase system protein PhnL
C380_02590	COG3454	Phosphonate metabolism
C380_02595	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C380_02600	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C380_02605	COG3639	organic phosphonate transmembrane transporter activity
C380_02630	COG0697	spore germination
C380_02635	COG0251	oxidation-reduction process
C380_02645	COG1960	acyl-CoA dehydrogenase activity
C380_02650	COG1024	Enoyl-CoA hydratase
C380_02665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C380_02700	COG0559	Belongs to the binding-protein-dependent transport system permease family
C380_02715	COG3409	Peptidoglycan-binding domain 1 protein
C380_02715	COG3267	Type II secretory pathway component ExeA
C380_02730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C380_02735	COG0840	transmembrane signaling receptor activity
C380_02755	COG1187	pseudouridine synthase activity
C380_02770	COG0326	Molecular chaperone. Has ATPase activity
C380_02785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C380_02795	COG0515	serine threonine protein kinase
C380_02795	COG2815	serine threonine protein kinase
C380_02810	COG1764	response to oxidative stress
C380_02815	COG1846	Transcriptional regulator
C380_02820	COG1024	Enoyl-CoA hydratase
C380_02825	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_02850	COG0842	Transport permease protein
C380_02860	COG2197	response regulator
C380_02865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C380_02870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_02875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C380_02875	COG1116	anion transmembrane transporter activity
C380_02880	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C380_02900	COG0446	pyridine nucleotide-disulphide oxidoreductase
C380_02940	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C380_02950	COG1131	(ABC) transporter
C380_02955	COG3186	Phenylalanine-4-hydroxylase
C380_02970	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C380_02975	COG1522	sequence-specific DNA binding
C380_02990	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C380_02995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C380_03015	COG0752	glycyl-tRNA synthetase alpha subunit
C380_03020	COG0751	glycine-tRNA ligase activity
C380_03025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C380_03045	COG1652	LysM domain
C380_03050	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C380_03070	COG4221	oxidoreductase activity
C380_03115	COG0438	transferase activity, transferring glycosyl groups
C380_03125	COG0463	Glycosyl transferase, family 2
C380_03135	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C380_03150	COG0438	transferase activity, transferring glycosyl groups
C380_03160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C380_03185	COG1181	Belongs to the D-alanine--D-alanine ligase family
C380_03195	COG0438	transferase activity, transferring glycosyl groups
C380_03240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C380_03245	COG0745	RESPONSE REGULATOR receiver
C380_03255	COG1309	transcriptional regulator
C380_03265	COG1960	acyl-CoA dehydrogenase activity
C380_03275	COG1024	Enoyl-CoA hydratase
C380_03275	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_03285	COG0183	Belongs to the thiolase family
C380_03300	COG1024	Enoyl-CoA hydratase
C380_03310	COG1028	Short-chain dehydrogenase reductase Sdr
C380_03315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C380_03320	COG4335	DNA alkylation repair
C380_03325	COG1960	acyl-CoA dehydrogenase activity
C380_03330	COG1024	Enoyl-CoA hydratase
C380_03340	COG1960	acyl-CoA dehydrogenase activity
C380_03345	COG3246	L-lysine catabolic process to acetate
C380_03360	COG1024	Enoyl-CoA hydratase
C380_03360	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_03365	COG0183	Belongs to the thiolase family
C380_03375	COG1960	acyl-CoA dehydrogenase activity
C380_03385	COG1022	Amp-dependent synthetase and ligase
C380_03395	COG0411	ABC transporter
C380_03405	COG0559	Belongs to the binding-protein-dependent transport system permease family
C380_03410	COG1024	Enoyl-CoA hydratase
C380_03415	COG2050	protein possibly involved in aromatic compounds catabolism
C380_03425	COG1607	acyl-coa hydrolase
C380_03430	COG5265	(ABC) transporter
C380_03435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C380_03445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_03460	COG0583	DNA-binding transcription factor activity
C380_03470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C380_03475	COG0765	amino acid transport
C380_03480	COG0765	amino acid transport
C380_03485	COG1126	abc transporter atp-binding protein
C380_03500	COG3181	Tripartite tricarboxylate transporter family receptor
C380_03505	COG0418	dihydroorotase activity
C380_03515	COG0501	Belongs to the peptidase M48B family
C380_03520	COG0840	transmembrane signaling receptor activity
C380_03525	COG0471	metal ion transport
C380_03535	COG1473	amidohydrolase
C380_03545	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C380_03550	COG0392	lysyltransferase activity
C380_03555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C380_03560	COG3568	Endonuclease Exonuclease Phosphatase
C380_03575	COG3541	Predicted nucleotidyltransferase
C380_03580	COG1690	Belongs to the RtcB family
C380_03600	COG4650	regulator
C380_03620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C380_03625	COG2814	Major facilitator Superfamily
C380_03630	COG0583	DNA-binding transcription factor activity
C380_03640	COG0625	glutathione transferase activity
C380_03645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C380_03655	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C380_03660	COG0681	Belongs to the peptidase S26 family
C380_03665	COG0840	transmembrane signaling receptor activity
C380_03670	COG0835	chemotaxis
C380_03680	COG0523	cobalamin synthesis protein
C380_03685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C380_03695	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C380_03700	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C380_03705	COG2001	Belongs to the MraZ family
C380_03710	COG0275	rRNA processing
C380_03725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C380_03730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C380_03735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C380_03740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C380_03745	COG0772	Belongs to the SEDS family
C380_03750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C380_03755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C380_03760	COG1181	Belongs to the D-alanine--D-alanine ligase family
C380_03765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C380_03775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C380_03780	COG0840	transmembrane signaling receptor activity
C380_03785	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C380_03795	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C380_03800	COG0840	transmembrane signaling receptor activity
C380_03865	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C380_03870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C380_03875	COG1765	OsmC-like protein
C380_03880	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C380_03890	COG0747	negative chemotaxis
C380_03895	COG0601	transmembrane transport
C380_03900	COG1473	amidohydrolase
C380_03915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C380_03920	COG0444	Belongs to the ABC transporter superfamily
C380_03925	COG4608	Belongs to the ABC transporter superfamily
C380_03930	COG0583	DNA-binding transcription factor activity
C380_03935	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_03935	COG1024	Enoyl-CoA hydratase
C380_03940	COG0183	Belongs to the thiolase family
C380_03945	COG1960	acyl-CoA dehydrogenase activity
C380_03950	COG1960	acyl-CoA dehydrogenase activity
C380_03955	COG1024	Enoyl-CoA hydratase
C380_03960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C380_03975	COG0318	PFAM AMP-dependent synthetase and ligase
C380_04000	COG1840	ABC-type Fe3 transport system, periplasmic component
C380_04010	COG3842	ATPase activity
C380_04015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C380_04020	COG0642	Histidine kinase
C380_04025	COG0745	RESPONSE REGULATOR receiver
C380_04045	COG0395	ABC-type sugar transport system, permease component
C380_04050	COG3842	ATPase activity
C380_04055	COG0837	glucose binding
C380_04060	COG0346	lactoylglutathione lyase activity
C380_04065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C380_04070	COG0166	Belongs to the GPI family
C380_04095	COG0800	Aldolase
C380_04105	COG0459	protein refolding
C380_04110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C380_04115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C380_04120	COG0583	DNA-binding transcription factor activity
C380_04125	COG0723	plastoquinol--plastocyanin reductase activity
C380_04130	COG3604	Transcriptional regulator
C380_04135	COG1309	transcriptional regulator
C380_04140	COG0493	'glutamate synthase
C380_04150	COG1953	Uracil, thiamine, allantoin
C380_04165	COG1056	cytidyltransferase-related domain
C380_04165	COG1051	belongs to the nudix hydrolase family
C380_04170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C380_04170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C380_04175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C380_04190	COG3706	GGDEF domain
C380_04190	COG0745	RESPONSE REGULATOR receiver
C380_04205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C380_04215	COG1560	Kdo2-lipid A biosynthetic process
C380_04225	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C380_04235	COG1333	cytochrome c biogenesis protein
C380_04240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C380_04245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C380_04250	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C380_04265	COG1965	Belongs to the frataxin family
C380_04305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C380_04310	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C380_04330	COG0067	glutamate synthase
C380_04330	COG0070	glutamate synthase
C380_04330	COG0069	glutamate synthase activity
C380_04340	COG1127	ABC transporter
C380_04345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C380_04350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C380_04355	COG2853	Lipoprotein
C380_04370	COG1131	(ABC) transporter
C380_04375	COG0842	Transport permease protein
C380_04380	COG5007	Belongs to the BolA IbaG family
C380_04385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C380_04390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C380_04415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C380_04420	COG0131	Imidazoleglycerol-phosphate dehydratase
C380_04425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C380_04430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C380_04435	COG0107	imidazoleglycerol-phosphate synthase activity
C380_04440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C380_04445	COG0140	phosphoribosyl-ATP diphosphatase activity
C380_04465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C380_04470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C380_04475	COG0805	protein transport
C380_04480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C380_04485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C380_04490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C380_04495	COG1970	mechanosensitive ion channel activity
C380_04500	COG0723	plastoquinol--plastocyanin reductase activity
C380_04505	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C380_04510	COG2857	Cytochrome c1
C380_04515	COG0625	glutathione transferase activity
C380_04520	COG2969	positive regulation of protein catabolic process
C380_04530	COG0739	heme binding
C380_04535	COG0653	protein targeting
C380_04540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C380_04550	COG0494	nUDIX hydrolase
C380_04555	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C380_04560	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C380_04565	COG0237	dephospho-CoA kinase activity
C380_04585	COG0142	geranyltranstransferase activity
C380_04590	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C380_04595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C380_04600	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C380_04605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C380_04610	COG0494	nUDIX hydrolase
C380_04615	COG0442	prolyl-tRNA aminoacylation
C380_04620	COG0741	lytic transglycosylase activity
C380_04625	COG1253	flavin adenine dinucleotide binding
C380_04630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C380_04635	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C380_04640	COG2890	protein-(glutamine-N5) methyltransferase activity
C380_04645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C380_04650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C380_04665	COG0584	glycerophosphoryl diester phosphodiesterase
C380_04675	COG3842	ATPase activity
C380_04680	COG0395	ABC-type sugar transport system, permease component
C380_04685	COG1175	transmembrane transport
C380_04690	COG1653	transport
C380_04695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C380_04715	COG2226	methyltransferase
C380_04730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C380_04755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C380_04780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C380_04785	COG0302	gtp cyclohydrolase
C380_04810	COG0588	phosphoglycerate mutase activity
C380_04830	COG0154	amidase activity
C380_04835	COG0747	negative chemotaxis
C380_04840	COG4608	Belongs to the ABC transporter superfamily
C380_04850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C380_04860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C380_04865	COG0193	aminoacyl-tRNA hydrolase activity
C380_04870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C380_04875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C380_04880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C380_04885	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C380_04895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C380_04910	COG1660	Displays ATPase and GTPase activities
C380_04915	COG0497	DNA recombination
C380_04920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C380_04925	COG1420	regulation of RNA biosynthetic process
C380_04935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C380_04940	COG1758	RNA polymerase activity
C380_04945	COG0194	GDP metabolic process
C380_04950	COG1561	YicC-like family, N-terminal region
C380_04970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C380_04975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C380_04985	COG5001	Diguanylate cyclase
C380_04985	COG3300	MHYT domain
C380_05020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C380_05025	COG0830	nickel cation binding
C380_05030	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C380_05035	COG0454	-acetyltransferase
C380_05040	COG0804	urea catabolic process
C380_05045	COG0832	Belongs to the urease beta subunit family
C380_05055	COG0831	urea catabolic process
C380_05095	COG3706	GGDEF domain
C380_05095	COG0745	RESPONSE REGULATOR receiver
C380_05110	COG2814	Major facilitator Superfamily
C380_05120	COG0559	Belongs to the binding-protein-dependent transport system permease family
C380_05135	COG0410	ABC transporter
C380_05145	COG1597	lipid kinase activity
C380_05165	COG0436	Aminotransferase
C380_05190	COG0829	nickel cation binding
C380_05200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_05225	COG0402	S-adenosylhomocysteine deaminase activity
C380_05245	COG0590	tRNA wobble adenosine to inosine editing
C380_05275	COG3622	Belongs to the hyi family
C380_05285	COG0235	Class ii aldolase
C380_05290	COG3395	kinase activity
C380_05295	COG2084	Dehydrogenase
C380_05300	COG2610	gluconate transmembrane transporter activity
C380_05305	COG2186	Transcriptional regulator
C380_05310	COG1752	Esterase of the alpha-beta hydrolase superfamily
C380_05325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_05340	COG0281	malic enzyme
C380_05340	COG0280	phosphate acetyltransferase
C380_05345	COG2233	PERMEase
C380_05350	COG2186	Transcriptional regulator
C380_05355	COG1301	dicarboxylic acid transport
C380_05360	COG0405	Gamma-glutamyltransferase
C380_05380	COG2186	Transcriptional regulator
C380_05405	COG5001	Diguanylate cyclase
C380_05405	COG3300	MHYT domain
C380_05425	COG3706	GGDEF domain
C380_05430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C380_05445	COG1129	ABC transporter
C380_05470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C380_05475	COG0537	adenosine 5'-monophosphoramidase activity
C380_05485	COG0402	S-adenosylhomocysteine deaminase activity
C380_05495	COG0717	Belongs to the dCTP deaminase family
C380_05505	COG0745	RESPONSE REGULATOR receiver
C380_05505	COG3706	GGDEF domain
C380_05520	COG2321	neutral zinc metallopeptidase
C380_05525	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C380_05525	COG2066	Belongs to the glutaminase family
C380_05530	COG2346	COG2346, Truncated hemoglobins
C380_05535	COG1704	LemA family
C380_05540	COG0501	Belongs to the peptidase M48B family
C380_05560	COG0737	Belongs to the 5'-nucleotidase family
C380_05570	COG2003	Belongs to the UPF0758 family
C380_05575	COG1047	Peptidyl-prolyl cis-trans
C380_05580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C380_05590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C380_05595	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C380_05640	COG5002	protein histidine kinase activity
C380_05665	COG0789	Transcriptional regulator
C380_05720	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C380_05750	COG0789	Transcriptional regulator
C380_05760	COG0671	phosphoesterase, PA-phosphatase related
C380_05765	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C380_05770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C380_05795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C380_05800	COG3339	Conserved Protein
C380_05850	COG2814	Major facilitator Superfamily
C380_05855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C380_05855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C380_05875	COG0582	viral genome integration into host DNA
C380_05880	COG0582	viral genome integration into host DNA
C380_05885	COG4974	Belongs to the 'phage' integrase family
C380_05890	COG2010	Cytochrome c
C380_05945	COG0583	DNA-binding transcription factor activity
C380_05950	COG4974	Belongs to the 'phage' integrase family
C380_05955	COG0582	viral genome integration into host DNA
C380_05960	COG0582	viral genome integration into host DNA
C380_05965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C380_05970	COG0582	viral genome integration into host DNA
C380_05975	COG0582	viral genome integration into host DNA
C380_05980	COG4974	Belongs to the 'phage' integrase family
C380_05990	COG0300	oxidoreductase activity
C380_06010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C380_06035	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C380_06040	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C380_06050	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C380_06065	COG2217	Heavy metal translocating P-type atpase
C380_06070	COG2326	polyphosphate kinase activity
C380_06100	COG3039	Transposase
C380_06170	COG2132	Multicopper oxidase
C380_06180	COG3039	Transposase
C380_06185	COG2801	Transposase and inactivated derivatives
C380_06325	COG0582	viral genome integration into host DNA
C380_06330	COG0582	viral genome integration into host DNA
C380_06380	COG0740	serine-type endopeptidase activity
C380_06385	COG0709	Synthesizes selenophosphate from selenide and ATP
C380_06390	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C380_06405	COG0745	RESPONSE REGULATOR receiver
C380_06420	COG0180	Tryptophanyl-tRNA synthetase
C380_06425	COG1994	Peptidase M50
C380_06435	COG0009	L-threonylcarbamoyladenylate synthase
C380_06440	COG0613	PHP domain protein
C380_06445	COG0840	transmembrane signaling receptor activity
C380_06470	COG4591	ABC-type transport system involved in lipoprotein release permease component
C380_06475	COG1136	(ABC) transporter
C380_06490	COG0714	Associated with various cellular activities
C380_06495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C380_06500	COG0084	hydrolase, TatD family'
C380_06515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C380_06540	COG4783	chaperone-mediated protein folding
C380_06550	COG1028	Short-chain dehydrogenase reductase Sdr
C380_06565	COG0697	spore germination
C380_06580	COG1091	dTDP-4-dehydrorhamnose reductase activity
C380_06585	COG0583	DNA-binding transcription factor activity
C380_06590	COG0583	DNA-binding transcription factor activity
C380_06600	COG1283	sodium-dependent phosphate transmembrane transporter activity
C380_06605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C380_06610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C380_06615	COG0196	riboflavin kinase activity
C380_06630	COG1960	acyl-CoA dehydrogenase activity
C380_06635	COG1960	acyl-CoA dehydrogenase activity
C380_06640	COG3132	Protein of unknown function, DUF480
C380_06645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C380_06660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C380_06660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C380_06670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C380_06675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C380_06680	COG0492	ferredoxin-NADP+ reductase activity
C380_06690	COG1674	ftsk spoiiie
C380_06695	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C380_06700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C380_06710	COG4585	Histidine kinase
C380_06730	COG0411	ABC transporter
C380_06745	COG1392	Phosphate transport regulator
C380_06750	COG0306	phosphate transporter
C380_06765	COG0228	four-way junction DNA binding
C380_06770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C380_06775	COG0336	Belongs to the RNA methyltransferase TrmD family
C380_06780	COG0335	large ribosomal subunit rRNA binding
C380_06790	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C380_06795	COG1162	GTPase activity
C380_06800	COG2154	pterin-4-alpha-carbinolamine dehydratase
C380_06805	COG0501	Belongs to the peptidase M48B family
C380_06810	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C380_06815	COG0513	Belongs to the DEAD box helicase family
C380_06825	COG2814	Major facilitator Superfamily
C380_06830	COG2084	Dehydrogenase
C380_06840	COG0516	GMP reductase activity
C380_06870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C380_06890	COG0625	glutathione transferase activity
C380_06910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C380_06930	COG5001	Diguanylate cyclase
C380_06930	COG4251	negative regulation of phosphorylation
C380_06930	COG3706	GGDEF domain
C380_06930	COG2203	Gaf domain
C380_06935	COG0412	Dienelactone hydrolase
C380_06955	COG3275	phosphorelay sensor kinase activity
C380_06960	COG0165	Argininosuccinate lyase
C380_06985	COG0753	catalase activity
C380_07005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C380_07010	COG3447	MASE1 domain protein
C380_07010	COG5001	Diguanylate cyclase
C380_07010	COG5002	protein histidine kinase activity
C380_07015	COG1304	FMN binding
C380_07025	COG1595	DNA-templated transcription, initiation
C380_07070	COG0583	DNA-binding transcription factor activity
C380_07075	COG1012	belongs to the aldehyde dehydrogenase family
C380_07095	COG0028	Belongs to the TPP enzyme family
C380_07100	COG0583	DNA-binding transcription factor activity
C380_07105	COG0697	spore germination
C380_07110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C380_07115	COG0840	transmembrane signaling receptor activity
C380_07125	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C380_07125	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C380_07135	COG3022	response to hydroperoxide
C380_07140	COG1530	ribonuclease E activity
C380_07160	COG0616	signal peptide processing
C380_07160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C380_07165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C380_07170	COG0424	maF-like protein
C380_07175	COG1399	metal-binding, possibly nucleic acid-binding protein
C380_07180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C380_07185	COG0416	fatty acid biosynthetic process
C380_07190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C380_07195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C380_07200	COG1028	Short-chain dehydrogenase reductase Sdr
C380_07205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C380_07210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C380_07235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C380_07240	COG0481	GTPase activity
C380_07245	COG0681	Belongs to the peptidase S26 family
C380_07255	COG0571	ribonuclease III activity
C380_07260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C380_07265	COG1381	Involved in DNA repair and RecF pathway recombination
C380_07270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C380_07275	COG0736	holo-[acyl-carrier-protein] synthase activity
C380_07280	COG1472	Belongs to the glycosyl hydrolase 3 family
C380_07290	COG3706	GGDEF domain
C380_07295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C380_07300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C380_07305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C380_07335	COG0367	asparagine synthase
C380_07340	COG0438	transferase activity, transferring glycosyl groups
C380_07370	COG2963	transposase activity
C380_07390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C380_07410	COG0762	integral membrane protein
C380_07415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C380_07420	COG0159	tryptophan synthase activity
C380_07425	COG0133	tryptophan synthase activity
C380_07430	COG0135	phosphoribosylanthranilate isomerase activity
C380_07435	COG0101	tRNA pseudouridine synthase activity
C380_07445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C380_07450	COG0473	3-isopropylmalate dehydrogenase activity
C380_07455	COG0066	3-isopropylmalate dehydratase activity
C380_07465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C380_07475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C380_07480	COG0484	heat shock protein binding
C380_07485	COG0443	Heat shock 70 kDa protein
C380_07490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C380_07495	COG0360	Binds together with S18 to 16S ribosomal RNA
C380_07505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C380_07510	COG0359	binds to the 23S rRNA
C380_07515	COG0305	Participates in initiation and elongation during chromosome replication
C380_07525	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C380_07530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C380_07540	COG0436	Aminotransferase
C380_07565	COG1763	Mo-molybdopterin cofactor biosynthetic process
C380_07580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C380_07600	COG0314	molybdopterin synthase activity
C380_07610	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C380_07615	COG1185	polyribonucleotide nucleotidyltransferase activity
C380_07620	COG1028	Short-chain dehydrogenase reductase Sdr
C380_07620	COG3321	synthase
C380_07620	COG0604	alcohol dehydrogenase
C380_07625	COG0149	triose-phosphate isomerase activity
C380_07635	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C380_07640	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C380_07645	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C380_07650	COG0649	NAD binding
C380_07655	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C380_07660	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C380_07665	COG1034	ATP synthesis coupled electron transport
C380_07670	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C380_07675	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C380_07685	COG0713	ATP synthesis coupled electron transport
C380_07700	COG1007	ATP synthesis coupled electron transport
C380_07715	COG1132	(ABC) transporter
C380_07735	COG0559	Belongs to the binding-protein-dependent transport system permease family
C380_07750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C380_07755	COG0583	DNA-binding transcription factor activity
C380_07770	COG0071	Belongs to the small heat shock protein (HSP20) family
C380_07775	COG4181	ATPase activity
C380_07780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C380_07785	COG2814	Major facilitator Superfamily
C380_07810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C380_07815	COG0584	glycerophosphoryl diester phosphodiesterase
C380_07825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C380_07830	COG0586	Pfam SNARE associated Golgi protein
C380_07840	COG0840	transmembrane signaling receptor activity
C380_07850	COG0860	N-Acetylmuramoyl-L-alanine amidase
C380_07855	COG0802	atpase or kinase
C380_07860	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C380_07880	COG4974	Belongs to the 'phage' integrase family
C380_07890	COG3181	Tripartite tricarboxylate transporter family receptor
C380_07895	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C380_07900	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C380_07905	COG2833	Protein of unknown function (DUF455)
C380_07915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C380_07930	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C380_07935	COG0148	phosphopyruvate hydratase activity
C380_07945	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C380_07950	COG0504	CTP synthase activity
C380_07955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C380_07965	COG0756	dUTP diphosphatase activity
C380_07975	COG1047	Peptidyl-prolyl cis-trans
C380_07980	COG2850	peptidyl-arginine hydroxylation
C380_07995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C380_08000	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C380_08005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C380_08020	COG0187	DNA topoisomerase II activity
C380_08025	COG0741	lytic transglycosylase activity
C380_08035	COG0840	transmembrane signaling receptor activity
C380_08060	COG2308	Evidence 4 Homologs of previously reported genes of
C380_08075	COG4628	conserved protein (DUF2132)
C380_08105	COG0436	Aminotransferase
C380_08125	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C380_08190	COG3634	alkyl hydroperoxide reductase activity
C380_08195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C380_08210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C380_08230	COG0583	DNA-binding transcription factor activity
C380_08235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C380_08240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C380_08245	COG3181	Tripartite tricarboxylate transporter family receptor
C380_08250	COG0840	transmembrane signaling receptor activity
C380_08260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C380_08270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C380_08280	COG0318	PFAM AMP-dependent synthetase and ligase
C380_08305	COG1309	transcriptional regulator
C380_08310	COG0604	alcohol dehydrogenase
C380_08320	COG0405	Gamma-glutamyltransferase
C380_08325	COG3540	Alkaline phosphatase
C380_08330	COG3706	GGDEF domain
C380_08340	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C380_08345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C380_08355	COG0564	pseudouridine synthase activity
C380_08360	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C380_08365	COG1187	pseudouridine synthase activity
C380_08370	COG0105	UTP biosynthetic process
C380_08375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C380_08390	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C380_08395	COG0124	histidyl-tRNA synthetase
C380_08405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C380_08410	COG1160	GTP binding
C380_08415	COG1923	regulation of RNA biosynthetic process
C380_08420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C380_08430	COG0330	HflC and HflK could
C380_08435	COG0330	HflC and HflK could
C380_08445	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C380_08450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C380_08465	COG1187	pseudouridine synthase activity
C380_08505	COG3852	Histidine kinase
C380_08510	COG2204	response regulator
C380_08520	COG0708	Exodeoxyribonuclease III
C380_08540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C380_08570	COG0484	heat shock protein binding
C380_08765	COG3728	DNA packaging
C380_08765	COG5484	DNA packaging
C380_08895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C380_08905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C380_08925	COG1175	transmembrane transport
C380_08930	COG0395	ABC-type sugar transport system, permease component
C380_08945	COG0246	Mannitol dehydrogenase
C380_08950	COG2207	Transcriptional regulator
C380_08955	COG1070	Carbohydrate kinase
C380_08970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C380_08970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C380_08985	COG0277	FAD linked oxidase domain protein
C380_08995	COG1295	ribonuclease BN
C380_09005	COG2267	carboxylic ester hydrolase activity
C380_09025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C380_09040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C380_09045	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C380_09050	COG0741	lytic transglycosylase activity
C380_09070	COG0557	exoribonuclease II activity
C380_09085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C380_09085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C380_09090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C380_09100	COG0052	Belongs to the universal ribosomal protein uS2 family
C380_09105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C380_09110	COG0528	UMP kinase activity
C380_09115	COG0233	cytoplasmic translational termination
C380_09130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C380_09135	COG0750	zinc metalloprotease
C380_09150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C380_09155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C380_09160	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C380_09165	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C380_09170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C380_09175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C380_09180	COG0505	Belongs to the CarA family
C380_09185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C380_09190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C380_09205	COG1534	Rna-binding protein
C380_09210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C380_09215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C380_09220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C380_09225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C380_09250	COG0438	transferase activity, transferring glycosyl groups
C380_09270	COG0248	Ppx GppA phosphatase
C380_09280	COG0573	inorganic phosphate transmembrane transporter activity
C380_09285	COG0581	inorganic phosphate transmembrane transporter activity
C380_09290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C380_09300	COG0745	RESPONSE REGULATOR receiver
C380_09310	COG0534	Mate efflux family protein
C380_09320	COG0254	rRNA binding
C380_09325	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C380_09340	COG1074	ATP-dependent DNA helicase activity
C380_09345	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
C380_09350	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C380_09355	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C380_09360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C380_09380	COG1388	LysM domain
C380_09380	COG0741	lytic transglycosylase activity
C380_09385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C380_09395	COG0328	RNA-DNA hybrid ribonuclease activity
C380_09400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_09405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C380_09415	COG0303	'Molybdopterin
C380_09425	COG0746	molybdenum cofactor guanylyltransferase activity
C380_09430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C380_09525	COG1773	rubredoxin
C380_09550	COG0745	RESPONSE REGULATOR receiver
C380_09555	COG2205	protein histidine kinase activity
C380_09585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C380_09600	COG0835	chemotaxis
C380_09605	COG0840	transmembrane signaling receptor activity
C380_09615	COG0840	transmembrane signaling receptor activity
C380_09625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C380_09625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C380_09630	COG0347	Belongs to the P(II) protein family
C380_09640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C380_09665	COG0028	Belongs to the TPP enzyme family
C380_09670	COG0440	acetolactate synthase activity
C380_09675	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C380_09680	COG1183	phosphatidylcholine synthase activity
C380_09685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C380_09695	COG1414	Transcriptional regulator
C380_09700	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C380_09705	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C380_09955	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C380_09970	COG0242	peptide deformylase activity
C380_09975	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C380_09980	COG0024	Methionine aminopeptidase
C380_09985	COG0047	phosphoribosylformylglycinamidine synthase activity
C380_09985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C380_10015	COG2354	Protein conserved in bacteria
C380_10020	COG3047	cAMP biosynthetic process
C380_10025	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C380_10030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C380_10040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C380_10045	COG0826	peptidase U32
C380_10065	COG1619	proteins homologs of microcin C7 resistance protein MccF
C380_10115	COG1024	Enoyl-CoA hydratase
C380_10120	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_10135	COG2022	thiamine diphosphate biosynthetic process
C380_10150	COG0351	phosphomethylpyrimidine kinase
C380_10160	COG0492	ferredoxin-NADP+ reductase activity
C380_10165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C380_10170	COG0529	Catalyzes the synthesis of activated sulfate
C380_10170	COG2895	sulfate adenylyltransferase (ATP) activity
C380_10175	COG0175	sulfate reduction
C380_10195	COG0730	response to heat
C380_10200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C380_10200	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C380_10205	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C380_10210	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C380_10215	COG0431	NADPH-dependent FMN reductase
C380_10220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C380_10225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C380_10235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_10240	COG1116	anion transmembrane transporter activity
C380_10250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C380_10270	COG2175	clavaminate synthase activity
C380_10280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_10285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_10295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C380_10300	COG3119	arylsulfatase activity
C380_10305	COG0583	DNA-binding transcription factor activity
C380_10315	COG0583	DNA-binding transcription factor activity
C380_10325	COG0165	Argininosuccinate lyase
C380_10370	COG0642	Histidine kinase
C380_10375	COG0745	RESPONSE REGULATOR receiver
C380_10400	COG4974	Belongs to the 'phage' integrase family
C380_10405	COG0582	viral genome integration into host DNA
C380_10410	COG0582	viral genome integration into host DNA
C380_10435	COG4948	Mandelate Racemase Muconate Lactonizing
C380_10440	COG0800	Aldolase
C380_10445	COG3734	2-keto-3-deoxy-galactonokinase
C380_10460	COG1172	Belongs to the binding-protein-dependent transport system permease family
C380_10465	COG1172	Belongs to the binding-protein-dependent transport system permease family
C380_10475	COG4214	carbohydrate transport
C380_10485	COG4213	ABC transporter substrate-binding protein
C380_10490	COG1879	ABC-type sugar transport system periplasmic component
C380_10495	COG1012	belongs to the aldehyde dehydrogenase family
C380_10510	COG3386	PFAM SMP-30 Gluconolaconase
C380_10540	COG0583	DNA-binding transcription factor activity
C380_10545	COG3550	peptidyl-serine autophosphorylation
C380_10560	COG2814	Major facilitator Superfamily
C380_10570	COG2814	Major facilitator Superfamily
C380_10575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C380_10580	COG2011	ABC-type metal ion transport system permease component
C380_10585	COG0454	-acetyltransferase
C380_10585	COG0456	acetyltransferase
C380_10605	COG0583	DNA-binding transcription factor activity
C380_10615	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C380_10620	COG0789	Transcriptional regulator
C380_10635	COG2183	response to ionizing radiation
C380_10680	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C380_10685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C380_10690	COG0470	DNA polymerase III
C380_10700	COG0084	hydrolase, TatD family'
C380_10710	COG1132	(ABC) transporter
C380_10715	COG0823	Involved in the tonB-independent uptake of proteins
C380_10720	COG2885	chlorophyll binding
C380_10730	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C380_10790	COG2974	May be involved in recombination
C380_10875	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C380_10880	COG3657	addiction module killer protein
C380_10905	COG0567	Dehydrogenase, E1 component
C380_10910	COG0508	dehydrogenase complex catalyzes the overall conversion of
C380_10915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C380_10920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C380_10930	COG0631	protein serine/threonine phosphatase activity
C380_10940	COG1199	ATP-dependent helicase activity
C380_10955	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C380_10960	COG0542	response to heat
C380_10965	COG2982	Protein involved in outer membrane biogenesis
C380_10970	COG0564	pseudouridine synthase activity
C380_10980	COG1177	transmembrane transport
C380_10985	COG1176	ABC-type spermidine putrescine transport system, permease component I
C380_10995	COG3842	ATPase activity
C380_11000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C380_11005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C380_11010	COG1802	Transcriptional regulator
C380_11015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_11020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_11040	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C380_11040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C380_11050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C380_11055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C380_11060	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C380_11065	COG3706	GGDEF domain
C380_11070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C380_11075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C380_11080	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C380_11080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C380_11085	COG0583	DNA-binding transcription factor activity
C380_11090	COG1741	Belongs to the pirin family
C380_11095	COG2259	Doxx family
C380_11110	COG1741	Belongs to the pirin family
C380_11120	COG0455	bacterial-type flagellum organization
C380_11125	COG3706	GGDEF domain
C380_11125	COG0745	RESPONSE REGULATOR receiver
C380_11155	COG4181	ATPase activity
C380_11160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C380_11165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C380_11190	COG0179	Fumarylacetoacetate (FAA) hydrolase
C380_11205	COG3550	peptidyl-serine autophosphorylation
C380_11220	COG3048	D-serine ammonia-lyase activity
C380_11230	COG0154	amidase activity
C380_11245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C380_11250	COG1739	Uncharacterized protein family UPF0029
C380_11265	COG0456	acetyltransferase
C380_11265	COG1846	Transcriptional regulator
C380_11285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C380_11290	COG3384	dioxygenase
C380_11310	COG1959	2 iron, 2 sulfur cluster binding
C380_11315	COG1104	cysteine desulfurase activity
C380_11320	COG0822	iron-sulfur transferase activity
C380_11335	COG0443	Heat shock 70 kDa protein
C380_11345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C380_11355	COG0579	oxidoreductase
C380_11375	COG0167	dihydroorotate dehydrogenase activity
C380_11380	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C380_11395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C380_11400	COG4566	intracellular signal transduction
C380_11410	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C380_11415	COG0508	dehydrogenase complex catalyzes the overall conversion of
C380_11420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C380_11430	COG0527	aspartate kinase activity
C380_11440	COG1850	ribulose-bisphosphate carboxylase activity
C380_11455	COG1126	abc transporter atp-binding protein
C380_11460	COG0765	amino acid transport
C380_11465	COG0765	amino acid transport
C380_11475	COG0697	spore germination
C380_11480	COG0583	DNA-binding transcription factor activity
C380_11485	COG1349	DNA-binding transcription factor activity
C380_11490	COG0494	nUDIX hydrolase
C380_11495	COG2366	antibiotic biosynthetic process
C380_11500	COG4977	sequence-specific DNA binding
C380_11505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C380_11540	COG2169	Transcriptional regulator
C380_11540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C380_11590	COG0791	NLP P60 protein
C380_11595	COG2133	pyrroloquinoline quinone binding
C380_11600	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C380_11605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C380_11615	COG0477	Major facilitator Superfamily
C380_11620	COG1473	amidohydrolase
C380_11625	COG2066	Belongs to the glutaminase family
C380_11690	COG1538	Outer membrane efflux protein
C380_11700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C380_11710	COG3293	Transposase
C380_11730	COG1309	transcriptional regulator
C380_11735	COG2188	Transcriptional regulator
C380_11760	COG0410	ABC transporter
C380_11770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C380_11775	COG0066	3-isopropylmalate dehydratase activity
C380_11805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C380_11815	COG1136	(ABC) transporter
C380_11850	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C380_11880	COG0642	Histidine kinase
C380_11885	COG3842	ATPase activity
C380_11905	COG0259	pyridoxamine-phosphate oxidase activity
C380_11910	COG1309	transcriptional regulator
C380_11935	COG1304	FMN binding
C380_11945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C380_11950	COG2032	superoxide dismutase activity
C380_11965	COG0346	lactoylglutathione lyase activity
C380_11995	COG1028	Short-chain dehydrogenase reductase Sdr
C380_12005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C380_12005	COG3453	Protein conserved in bacteria
C380_12020	COG0640	Transcriptional regulator
C380_12050	COG5002	protein histidine kinase activity
C380_12050	COG2205	protein histidine kinase activity
C380_12050	COG0784	Response regulator, receiver
C380_12055	COG3437	response regulator, receiver
C380_12060	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C380_12080	COG0439	Biotin carboxylase
C380_12085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C380_12090	COG1703	isobutyryl-CoA mutase activity
C380_12100	COG1802	Transcriptional regulator
C380_12105	COG1022	Amp-dependent synthetase and ligase
C380_12140	COG4626	Terminase
C380_12140	COG1802	Transcriptional regulator
C380_12195	COG0582	viral genome integration into host DNA
C380_12200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C380_12225	COG2878	Part of a membrane complex involved in electron transport
C380_12230	COG0840	transmembrane signaling receptor activity
C380_12235	COG0436	Aminotransferase
C380_12240	COG2171	N-acyltransferase activity
C380_12250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C380_12255	COG2890	protein-(glutamine-N5) methyltransferase activity
C380_12265	COG1028	Short-chain dehydrogenase reductase Sdr
C380_12270	COG5001	Diguanylate cyclase
C380_12285	COG0183	Belongs to the thiolase family
C380_12290	COG3243	poly(R)-hydroxyalkanoic acid synthase
C380_12335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C380_12345	COG1196	nuclear chromosome segregation
C380_12350	COG3706	GGDEF domain
C380_12360	COG1396	sequence-specific DNA binding
C380_12360	COG3800	Transcriptional regulator
C380_12405	COG1132	(ABC) transporter
C380_12430	COG2706	6-phosphogluconolactonase activity
C380_12435	COG3181	Tripartite tricarboxylate transporter family receptor
C380_12440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C380_12450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C380_12470	COG0583	DNA-binding transcription factor activity
C380_12475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C380_12480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C380_12490	COG1538	Outer membrane efflux protein
C380_12495	COG1566	PFAM secretion protein HlyD family protein
C380_12500	COG2814	Major facilitator Superfamily
C380_12525	COG1051	belongs to the nudix hydrolase family
C380_12540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C380_12575	COG1960	acyl-CoA dehydrogenase activity
C380_12605	COG3437	response regulator, receiver
C380_12605	COG3850	Histidine kinase
C380_12605	COG2205	protein histidine kinase activity
C380_12605	COG4999	Histidine kinase
C380_12625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C380_12630	COG1570	exodeoxyribonuclease VII activity
C380_12635	COG0811	peptide transport
C380_12640	COG0848	biopolymer transport protein
C380_12645	COG2835	tetraacyldisaccharide 4'-kinase activity
C380_12645	COG1663	tetraacyldisaccharide 4'-kinase activity
C380_12650	COG2835	tetraacyldisaccharide 4'-kinase activity
C380_12655	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C380_12660	COG0563	adenylate kinase activity
C380_12675	COG0252	asparaginase activity
C380_12680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C380_12685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C380_12715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C380_12735	COG0583	DNA-binding transcription factor activity
C380_12740	COG0436	Aminotransferase
C380_12750	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C380_12755	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C380_12760	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C380_12765	COG2205	protein histidine kinase activity
C380_12770	COG0745	RESPONSE REGULATOR receiver
C380_12780	COG0625	glutathione transferase activity
C380_12785	COG1530	ribonuclease E activity
C380_12790	COG0424	maF-like protein
C380_12795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C380_12800	COG0799	negative regulation of ribosome biogenesis
C380_12805	COG0408	coproporphyrinogen oxidase activity
C380_12810	COG0151	Belongs to the GarS family
C380_12815	COG0217	transcriptional regulatory protein
C380_12820	COG0433	COG0433 Predicted ATPase
C380_12830	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_12830	COG1024	Enoyl-CoA hydratase
C380_12835	COG1473	amidohydrolase
C380_12840	COG3181	Tripartite tricarboxylate transporter family receptor
C380_12855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C380_12860	COG1744	ABC transporter substrate-binding protein PnrA-like
C380_12880	COG4603	Belongs to the binding-protein-dependent transport system permease family
C380_12895	COG0402	S-adenosylhomocysteine deaminase activity
C380_12905	COG0842	Transport permease protein
C380_12910	COG1129	ABC transporter
C380_12910	COG0842	Transport permease protein
C380_12915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_12925	COG3706	GGDEF domain
C380_12945	COG0484	heat shock protein binding
C380_12950	COG0217	transcriptional regulatory protein
C380_12955	COG0700	Nucleoside recognition
C380_12960	COG0515	serine threonine protein kinase
C380_12960	COG2815	serine threonine protein kinase
C380_12970	COG2925	Exonuclease
C380_12975	COG2951	lytic endotransglycosylase activity
C380_12985	COG0587	DNA-directed DNA polymerase activity
C380_13000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C380_13010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C380_13025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C380_13030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C380_13035	COG3386	PFAM SMP-30 Gluconolaconase
C380_13060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C380_13065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C380_13080	COG3181	Tripartite tricarboxylate transporter family receptor
C380_13120	COG1028	Short-chain dehydrogenase reductase Sdr
C380_13160	COG1643	Atp-dependent helicase
C380_13165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C380_13175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C380_13180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C380_13180	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C380_13195	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C380_13215	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C380_13220	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C380_13225	COG4208	sulfate ABC transporter
C380_13235	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C380_13250	COG1595	DNA-templated transcription, initiation
C380_13265	COG0583	DNA-binding transcription factor activity
C380_13270	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C380_13310	COG5001	Diguanylate cyclase
C380_13310	COG4251	negative regulation of phosphorylation
C380_13310	COG2203	Gaf domain
C380_13310	COG3706	GGDEF domain
C380_13330	COG1960	acyl-CoA dehydrogenase activity
C380_13335	COG2153	protein acetylation
C380_13340	COG2130	NADP-dependent
C380_13350	COG1028	Short-chain dehydrogenase reductase Sdr
C380_13360	COG1960	acyl-CoA dehydrogenase activity
C380_13370	COG0183	Belongs to the thiolase family
C380_13375	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_13375	COG1024	Enoyl-CoA hydratase
C380_13385	COG0411	ABC transporter
C380_13395	COG0559	Belongs to the binding-protein-dependent transport system permease family
C380_13405	COG0318	PFAM AMP-dependent synthetase and ligase
C380_13410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C380_13415	COG2272	Belongs to the type-B carboxylesterase lipase family
C380_13420	COG2207	Transcriptional regulator
C380_13425	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C380_13430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C380_13435	COG2917	probably involved in intracellular septation
C380_13445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C380_13455	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C380_13460	COG0517	IMP dehydrogenase activity
C380_13470	COG0559	Belongs to the binding-protein-dependent transport system permease family
C380_13480	COG0411	ABC transporter
C380_13490	COG0688	phosphatidylethanolamine metabolic process
C380_13510	COG1228	amidohydrolase
C380_13525	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C380_13530	COG2986	histidine ammonia-lyase
C380_13545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_13555	COG5002	protein histidine kinase activity
C380_13555	COG3850	Histidine kinase
C380_13560	COG0745	RESPONSE REGULATOR receiver
C380_13580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C380_13595	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C380_13600	COG1605	Chorismate mutase
C380_13600	COG0077	Prephenate dehydratase
C380_13605	COG0287	Prephenate dehydrogenase
C380_13610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C380_13620	COG0776	regulation of translation
C380_13630	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C380_13640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C380_13640	COG2111	Na H antiporter
C380_13645	COG1006	Multisubunit Na H antiporter MnhC subunit
C380_13650	COG0651	ATP synthesis coupled electron transport
C380_13655	COG1863	multisubunit Na H antiporter MnhE subunit
C380_13660	COG2212	antiporter activity
C380_13665	COG1320	monovalent cation:proton antiporter activity
C380_13695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C380_13710	COG1322	Protein conserved in bacteria
C380_13725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C380_13735	COG0123	including yeast histone deacetylase and acetoin utilization protein
C380_13745	COG1840	ABC-type Fe3 transport system, periplasmic component
C380_13760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C380_13780	COG0285	dihydrofolate synthase activity
C380_13785	COG1393	Belongs to the ArsC family
C380_13795	COG3123	guanosine phosphorylase activity
C380_13800	COG0137	argininosuccinate synthase activity
C380_13805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C380_13810	COG1666	GTP binding
C380_13815	COG3577	Aspartyl protease
C380_13825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C380_13830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C380_13835	COG0583	DNA-binding transcription factor activity
C380_13840	COG3181	Tripartite tricarboxylate transporter family receptor
C380_13850	COG0667	Aldo Keto reductase
C380_13855	COG2267	carboxylic ester hydrolase activity
C380_13870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C380_13875	COG0308	aminopeptidase N
C380_13880	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C380_13900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C380_13915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C380_13925	COG1111	helicase
C380_13925	COG1205	dead DEAH box helicase
C380_14005	COG0582	viral genome integration into host DNA
C380_14010	COG0582	viral genome integration into host DNA
C380_14020	COG3039	Transposase
C380_14045	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C380_14160	COG0582	viral genome integration into host DNA
C380_14180	COG0789	Transcriptional regulator
C380_14185	COG0776	regulation of translation
C380_14190	COG0072	phenylalanine-tRNA ligase activity
C380_14190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C380_14195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C380_14200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C380_14205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C380_14210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C380_14215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C380_14235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C380_14245	COG4774	siderophore transport
C380_14250	COG3128	pkhd-type hydroxylase
C380_14285	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C380_14290	COG0670	Belongs to the BI1 family
C380_14300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C380_14315	COG0506	proline dehydrogenase activity
C380_14315	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C380_14315	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C380_14370	COG3504	Conjugal transfer protein
C380_14390	COG3451	type IV secretory pathway VirB4
C380_14400	COG3838	Conjugal transfer protein Trbc
C380_14405	COG4962	Type ii secretion system protein e
C380_14425	COG0583	DNA-binding transcription factor activity
C380_14440	COG1960	acyl-CoA dehydrogenase activity
C380_14445	COG2814	Major facilitator Superfamily
C380_14475	COG0318	PFAM AMP-dependent synthetase and ligase
C380_14480	COG0183	Belongs to the thiolase family
C380_14485	COG1024	Enoyl-CoA hydratase
C380_14505	COG4959	Type IV secretory pathway protease TraF
C380_14520	COG1192	Involved in chromosome partitioning
C380_14550	COG5489	Protein of unknown function (DUF736)
C380_14565	COG1475	DNA binding
C380_14610	COG0537	adenosine 5'-monophosphoramidase activity
C380_14620	COG0514	ATP-dependent DNA helicase (RecQ)
C380_14645	COG0582	viral genome integration into host DNA
C380_14650	COG0519	Catalyzes the synthesis of GMP from XMP
C380_14650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C380_14675	COG2914	Belongs to the UPF0125 (RnfH) family
C380_14680	COG2867	negative regulation of translational initiation
C380_14685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C380_14705	COG1024	Enoyl-CoA hydratase
C380_14720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C380_14725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C380_14730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C380_14735	COG0195	Participates in both transcription termination and antitermination
C380_14740	COG0779	Required for maturation of 30S ribosomal subunits
C380_14745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C380_14765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C380_14830	COG0066	3-isopropylmalate dehydratase activity
C380_14845	COG3181	Tripartite tricarboxylate transporter family receptor
C380_14850	COG0583	DNA-binding transcription factor activity
C380_14860	COG3040	lipid binding
C380_14865	COG4172	Belongs to the ABC transporter superfamily
C380_14870	COG4239	(ABC) transporter, permease
C380_14875	COG4174	ABC transporter (Permease)
C380_14880	COG4166	transmembrane transport
C380_14890	COG1793	dna ligase
C380_14895	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C380_14900	COG1982	Orn Lys Arg decarboxylase major
C380_14920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C380_14995	COG2132	Multicopper oxidase
C380_15000	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C380_15015	COG3191	aminopeptidase activity
C380_15050	COG0488	(ABC) transporter
C380_15055	COG0513	Belongs to the DEAD box helicase family
C380_15060	COG0702	epimerase
C380_15075	COG4651	solute:proton antiporter activity
C380_15075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C380_15085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C380_15090	COG0776	regulation of translation
C380_15095	COG0473	3-isopropylmalate dehydrogenase activity
C380_15100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C380_15105	COG0322	excinuclease ABC activity
C380_15120	COG3293	Transposase
C380_15135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C380_15140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C380_15145	COG0583	DNA-binding transcription factor activity
C380_15155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C380_15160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C380_15165	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
C380_15170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C380_15180	COG1028	Short-chain dehydrogenase reductase Sdr
C380_15190	COG0745	RESPONSE REGULATOR receiver
C380_15195	COG2205	protein histidine kinase activity
C380_15205	COG3181	Tripartite tricarboxylate transporter family receptor
C380_15210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C380_15215	COG1609	Transcriptional regulator
C380_15220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C380_15225	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C380_15225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C380_15230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C380_15245	COG0024	Methionine aminopeptidase
C380_15255	COG0560	Phosphoserine phosphatase
C380_15260	COG1959	2 iron, 2 sulfur cluster binding
C380_15285	COG0023	Translation Initiation Factor
C380_15295	COG0513	Belongs to the DEAD box helicase family
C380_15320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C380_15335	COG1902	pentaerythritol trinitrate reductase activity
C380_15335	COG0446	pyridine nucleotide-disulphide oxidoreductase
C380_15345	COG2900	Belongs to the SlyX family
C380_15350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C380_15375	COG0154	amidase activity
C380_15380	COG0583	DNA-binding transcription factor activity
C380_15385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C380_15390	COG3654	unkown
C380_15405	COG1802	Transcriptional regulator
C380_15410	COG3833	ABC-type maltose transport systems, permease component
C380_15415	COG1176	ABC-type spermidine putrescine transport system, permease component I
C380_15430	COG3706	GGDEF domain
C380_15430	COG0745	RESPONSE REGULATOR receiver
C380_15435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C380_15445	COG1492	cobalamin metabolic process
C380_15460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C380_15465	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C380_15470	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C380_15475	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C380_15480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C380_15485	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C380_15500	COG4206	TonB-dependent receptor
C380_15515	COG0730	response to heat
C380_15525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C380_15525	COG2199	diguanylate cyclase activity
C380_15540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C380_15575	COG3278	Belongs to the heme-copper respiratory oxidase family
C380_15585	COG2217	Heavy metal translocating P-type atpase
C380_15595	COG0318	PFAM AMP-dependent synthetase and ligase
C380_15615	COG1802	Transcriptional regulator
C380_15630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C380_15640	COG0129	dihydroxy-acid dehydratase activity
C380_15650	COG4654	Cytochrome c, class I
C380_15680	COG2205	protein histidine kinase activity
C380_15685	COG0745	RESPONSE REGULATOR receiver
C380_15695	COG0114	fumarate hydratase activity
C380_15710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C380_15715	COG1451	nucleotide metabolic process
C380_15775	COG2003	Belongs to the UPF0758 family
C380_15795	COG1475	DNA binding
C380_15810	COG1695	Transcriptional regulator
C380_15815	COG1393	Belongs to the ArsC family
C380_15820	COG0798	PFAM Bile acid sodium symporter
C380_15835	COG0640	Transcriptional regulator
C380_15840	COG5489	Protein of unknown function (DUF736)
C380_15870	COG1192	Involved in chromosome partitioning
C380_15900	COG3039	Transposase
C380_15905	COG3971	2-oxopent-4-enoate hydratase activity
C380_15910	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C380_15965	COG0583	DNA-binding transcription factor activity
C380_15985	COG4962	Type ii secretion system protein e
C380_15990	COG3838	Conjugal transfer protein Trbc
C380_16000	COG3451	type IV secretory pathway VirB4
C380_16030	COG2948	multi-organism process
C380_16060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C380_16065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C380_16070	COG0740	serine-type endopeptidase activity
C380_16075	COG0544	peptidyl-prolyl cis-trans isomerase activity
C380_16085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_16090	COG1562	ergosterol biosynthetic process
C380_16095	COG1760	l-serine dehydratase
C380_16110	COG1562	ergosterol biosynthetic process
C380_16115	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C380_16130	COG0642	Histidine kinase
C380_16155	COG1011	Hydrolase
C380_16160	COG1609	Transcriptional regulator
C380_16170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C380_16180	COG1126	abc transporter atp-binding protein
C380_16190	COG0765	amino acid transport
C380_16195	COG0765	amino acid transport
C380_16200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C380_16205	COG1067	ATP-dependent peptidase activity
C380_16210	COG0410	ABC transporter
C380_16225	COG0559	Belongs to the binding-protein-dependent transport system permease family
C380_16235	COG1024	Enoyl-CoA hydratase
C380_16280	COG1902	pentaerythritol trinitrate reductase activity
C380_16285	COG2267	carboxylic ester hydrolase activity
C380_16315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C380_16325	COG3046	protein related to deoxyribodipyrimidine photolyase
C380_16330	COG0415	Belongs to the DNA photolyase family
C380_16340	COG0415	Belongs to the DNA photolyase family
C380_16345	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C380_16355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C380_16390	COG0410	ABC transporter
C380_16395	COG0411	ABC transporter
C380_16410	COG2204	response regulator
C380_16440	COG0642	Histidine kinase
C380_16445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C380_16450	COG0037	tRNA processing
C380_16455	COG0840	transmembrane signaling receptor activity
C380_16460	COG0825	malonyl-CoA metabolic process
C380_16470	COG0215	cysteine-tRNA ligase activity
C380_16495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C380_16500	COG3228	Belongs to the MtfA family
C380_16515	COG1522	sequence-specific DNA binding
C380_16525	COG1522	sequence-specific DNA binding
C380_16535	COG3384	dioxygenase
C380_16545	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C380_16555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C380_16625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C380_16700	COG0564	pseudouridine synthase activity
C380_16710	COG3437	response regulator, receiver
C380_16745	COG2814	Major facilitator Superfamily
C380_16775	COG2918	glutathione biosynthetic process
C380_16780	COG1028	Short-chain dehydrogenase reductase Sdr
C380_16805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C380_16810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C380_16820	COG0824	Thioesterase
C380_16840	COG0477	Major facilitator Superfamily
C380_16850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C380_16855	COG1845	cytochrome c oxidase, subunit III
C380_16860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C380_16870	COG2205	protein histidine kinase activity
C380_16875	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C380_16880	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C380_16895	COG1049	propionate catabolic process, 2-methylcitrate cycle
C380_16910	COG0039	L-malate dehydrogenase activity
C380_16915	COG2188	Transcriptional regulator
C380_16925	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C380_16930	COG1053	succinate dehydrogenase
C380_16935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C380_16940	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C380_16945	COG0372	Belongs to the citrate synthase family
C380_16965	COG0300	oxidoreductase activity
C380_16975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C380_16985	COG2194	sulfuric ester hydrolase activity
C380_17000	COG2388	GCN5-related N-acetyl-transferase
C380_17025	COG1396	sequence-specific DNA binding
C380_17030	COG1802	Transcriptional regulator
C380_17060	COG0574	Belongs to the PEP-utilizing enzyme family
C380_17060	COG3848	Pyruvate phosphate dikinase
C380_17065	COG3848	Pyruvate phosphate dikinase
C380_17065	COG0574	Belongs to the PEP-utilizing enzyme family
C380_17085	COG0411	ABC transporter
C380_17095	COG3473	Maleate cis-trans isomerase
C380_17100	COG0596	Alpha beta hydrolase
C380_17105	COG2309	aminopeptidase activity
C380_17110	COG1335	isochorismatase
C380_17120	COG3181	Tripartite tricarboxylate transporter family receptor
C380_17125	COG0165	Argininosuccinate lyase
C380_17130	COG0583	DNA-binding transcription factor activity
C380_17135	COG3039	Transposase
C380_17150	COG0004	ammonium transporteR
C380_17155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C380_17160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C380_17170	COG2813	Specifically methylates the guanine in position
C380_17185	COG2197	response regulator
C380_17190	COG0784	Response regulator, receiver
C380_17190	COG2205	protein histidine kinase activity
C380_17190	COG2198	Histidine kinase
C380_17205	COG0542	response to heat
C380_17225	COG4968	Prepilin-type N-terminal cleavage methylation domain
C380_17275	COG1960	acyl-CoA dehydrogenase activity
C380_17290	COG3264	Mechanosensitive ion channel
C380_17290	COG1196	nuclear chromosome segregation
C380_17295	COG1024	Enoyl-CoA hydratase
C380_17305	COG0714	Associated with various cellular activities
C380_17320	COG2951	lytic endotransglycosylase activity
C380_17325	COG1131	(ABC) transporter
C380_17330	COG0842	Transport permease protein
C380_17335	COG0683	leucine binding
C380_17345	COG1136	(ABC) transporter
C380_17345	COG0577	efflux transmembrane transporter activity
C380_17350	COG1136	(ABC) transporter
C380_17350	COG0577	efflux transmembrane transporter activity
C380_17355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_17390	COG0410	ABC transporter
C380_17395	COG1012	belongs to the aldehyde dehydrogenase family
C380_17400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C380_17415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C380_17420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C380_17425	COG1116	anion transmembrane transporter activity
C380_17430	COG0517	IMP dehydrogenase activity
C380_17445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_17450	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_17455	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C380_17460	COG3265	gluconokinase activity
C380_17465	COG1609	Transcriptional regulator
C380_17470	COG0840	transmembrane signaling receptor activity
C380_17475	COG2223	nitrite transmembrane transporter activity
C380_17480	COG0515	serine threonine protein kinase
C380_17480	COG2815	serine threonine protein kinase
C380_17485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C380_17500	COG0243	molybdopterin cofactor binding
C380_17505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C380_17520	COG1607	acyl-coa hydrolase
C380_17535	COG0683	leucine binding
C380_17545	COG2081	HI0933 family
C380_17555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C380_17565	COG0583	DNA-binding transcription factor activity
C380_17570	COG0473	3-isopropylmalate dehydrogenase activity
C380_17595	COG0702	epimerase
C380_17600	COG0312	modulator of DNA gyrase
C380_17605	COG3028	Belongs to the UPF0307 family
C380_17610	COG0521	Mo-molybdopterin cofactor biosynthetic process
C380_17620	COG1045	serine acetyltransferase
C380_17650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C380_17705	COG1968	undecaprenyl-diphosphatase activity
C380_17735	COG3275	phosphorelay sensor kinase activity
C380_17745	COG1538	Outer membrane efflux protein
C380_17750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C380_17765	COG1280	lysine exporter protein (LysE YggA)
C380_17770	COG4133	protoheme IX ABC transporter activity
C380_17780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C380_17785	COG0385	Bile acid
C380_17790	COG2072	flavoprotein involved in K transport
C380_17795	COG0300	oxidoreductase activity
C380_17800	COG1414	Transcriptional regulator
C380_17825	COG2205	protein histidine kinase activity
C380_17825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C380_17840	COG0745	RESPONSE REGULATOR receiver
C380_17865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C380_17870	COG3608	succinylglutamate desuccinylase aspartoacylase
C380_17870	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C380_17910	COG0789	Transcriptional regulator
C380_17920	COG0655	NAD(P)H dehydrogenase (quinone) activity
C380_17930	COG0798	PFAM Bile acid sodium symporter
C380_17945	COG0640	Transcriptional regulator
C380_17950	COG2202	Pas domain
C380_17950	COG2199	diguanylate cyclase activity
C380_17950	COG2200	EAL domain
C380_17990	COG1126	abc transporter atp-binding protein
C380_18010	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_18015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C380_18020	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C380_18025	COG0142	geranyltranstransferase activity
C380_18030	COG1722	exodeoxyribonuclease VII activity
C380_18080	COG2369	cell adhesion
C380_18085	COG4383	Mu-like prophage protein gp29
C380_18090	COG4373	Mu-like prophage FluMu protein gp28
C380_18120	COG3772	lysozyme
C380_18145	COG3620	sequence-specific DNA binding
C380_18180	COG3409	Peptidoglycan-binding domain 1 protein
C380_18180	COG3267	Type II secretory pathway component ExeA
C380_18220	COG2974	May be involved in recombination
C380_18245	COG4388	Caudovirus prohead serine protease
C380_18255	COG4397	Mu-like prophage major head subunit gpT
C380_18325	COG0628	permease
C380_18335	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C380_18340	COG0181	hydroxymethylbilane synthase activity
C380_18360	COG3038	cytochrome b561
C380_18365	COG2353	YceI-like domain
C380_18380	COG0501	Belongs to the peptidase M48B family
C380_18390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C380_18395	COG0425	Belongs to the sulfur carrier protein TusA family
C380_18420	COG0583	DNA-binding transcription factor activity
C380_18425	COG1960	acyl-CoA dehydrogenase activity
C380_18430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C380_18455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_18470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C380_18475	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_18480	COG2910	NAD(P)H-binding
C380_18485	COG0583	DNA-binding transcription factor activity
C380_18495	COG0835	chemotaxis
C380_18495	COG0784	Response regulator, receiver
C380_18525	COG4566	intracellular signal transduction
C380_18540	COG0617	tRNA 3'-terminal CCA addition
C380_18550	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C380_18560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C380_18585	COG1917	Cupin 2, conserved barrel domain protein
C380_18585	COG4977	sequence-specific DNA binding
C380_18615	COG2912	Transglutaminase-like superfamily
C380_18620	COG0728	peptidoglycan biosynthetic process
C380_18625	COG0268	Binds directly to 16S ribosomal RNA
C380_18640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C380_18645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C380_18715	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C380_18725	COG3483	tryptophan 2,3-dioxygenase activity
C380_18750	COG2719	SpoVR family
C380_18755	COG2718	Belongs to the UPF0229 family
C380_18760	COG2766	serine protein kinase
C380_18765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C380_18780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C380_18795	COG2916	Histone family protein nucleoid-structuring protein H-NS
C380_18800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C380_18805	COG0513	Belongs to the DEAD box helicase family
C380_18810	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C380_18825	COG0724	RNA recognition motif
C380_18830	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C380_18850	COG0437	4 iron, 4 sulfur cluster binding
C380_18855	COG0243	molybdopterin cofactor binding
C380_18855	COG3383	formate dehydrogenase (NAD+) activity
C380_18885	COG3383	formate dehydrogenase (NAD+) activity
C380_18900	COG0489	protein tyrosine kinase activity
C380_18920	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C380_18920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C380_18950	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C380_18955	COG0602	queuosine metabolic process
C380_18960	COG0720	synthase
C380_18965	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C380_18975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C380_18980	COG0156	8-amino-7-oxononanoate synthase activity
C380_18990	COG1028	Short-chain dehydrogenase reductase Sdr
C380_19010	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C380_19020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C380_19025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C380_19040	COG2308	Evidence 4 Homologs of previously reported genes of
C380_19040	COG2307	Protein conserved in bacteria
C380_19045	COG1305	Transglutaminase-like
C380_19065	COG2308	Evidence 4 Homologs of previously reported genes of
C380_19085	COG5487	UPF0391 membrane protein
C380_19095	COG2197	response regulator
C380_19105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C380_19110	COG0793	Belongs to the peptidase S41A family
C380_19115	COG0588	phosphoglycerate mutase activity
C380_19120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C380_19130	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C380_19135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C380_19140	COG0019	diaminopimelate decarboxylase activity
C380_19145	COG0583	DNA-binding transcription factor activity
C380_19150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C380_19155	COG0742	ribosomal rna small subunit methyltransferase
C380_19160	COG0612	Peptidase, M16
C380_19165	COG0612	Peptidase, M16
C380_19185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C380_19190	COG3181	Tripartite tricarboxylate transporter family receptor
C380_19195	COG1999	signal sequence binding
C380_19200	COG0109	protoheme IX farnesyltransferase activity
C380_19225	COG1845	cytochrome c oxidase, subunit III
C380_19235	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C380_19245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C380_19260	COG2226	methyltransferase
C380_19265	COG1040	competence protein
C380_19270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C380_19275	COG0583	DNA-binding transcription factor activity
C380_19290	COG1280	lysine exporter protein (LysE YggA)
C380_19295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C380_19295	COG0475	glutathione-regulated potassium exporter activity
C380_19300	COG2860	membrane
C380_19315	COG0583	DNA-binding transcription factor activity
C380_19330	COG1028	Short-chain dehydrogenase reductase Sdr
C380_19335	COG0183	Belongs to the thiolase family
C380_19340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C380_19350	COG1414	Transcriptional regulator
C380_19380	COG0411	ABC transporter
C380_19390	COG0559	Belongs to the binding-protein-dependent transport system permease family
C380_19395	COG0066	3-isopropylmalate dehydratase activity
C380_19400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C380_19460	COG5006	permease, DMT superfamily
C380_19465	COG1522	sequence-specific DNA binding
C380_19470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C380_19475	COG0642	Histidine kinase
C380_19480	COG0745	RESPONSE REGULATOR receiver
C380_19485	COG1840	ABC-type Fe3 transport system, periplasmic component
C380_19490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C380_19510	COG2721	sulfolactate sulfo-lyase activity
C380_19525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_19535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C380_19540	COG2188	Transcriptional regulator
C380_19545	COG1012	belongs to the aldehyde dehydrogenase family
C380_19555	COG4773	Receptor
C380_19565	COG0784	Response regulator, receiver
C380_19565	COG2205	protein histidine kinase activity
C380_19565	COG5002	protein histidine kinase activity
C380_19570	COG1178	ABC-type Fe3 transport system permease component
C380_19575	COG3842	ATPase activity
C380_19615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C380_19620	COG0540	Belongs to the ATCase OTCase family
C380_19625	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C380_19630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C380_19635	COG1678	Uncharacterized ACR, COG1678
C380_19640	COG0415	Belongs to the DNA photolyase family
C380_19655	COG0840	transmembrane signaling receptor activity
C380_19660	COG0835	chemotaxis
C380_19675	COG1773	rubredoxin
C380_19685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C380_19690	COG1414	Transcriptional regulator
C380_19695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C380_19700	COG4654	Cytochrome c, class I
C380_19705	COG0138	bifunctional purine biosynthesis protein purh
C380_19710	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C380_19715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C380_19725	COG1238	metal cluster binding
C380_19730	COG3706	GGDEF domain
C380_19740	COG0012	GTP binding
C380_19745	COG3217	Mosc domain protein beta barrel domain protein
C380_19745	COG0633	Ferredoxin
C380_19750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C380_19755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C380_19765	COG1024	Enoyl-CoA hydratase
C380_19775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C380_19780	COG2205	protein histidine kinase activity
C380_19790	COG2204	response regulator
C380_19795	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C380_19805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C380_19810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C380_19840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C380_19860	COG2264	protein methyltransferase activity
C380_19865	COG0439	Biotin carboxylase
C380_19870	COG0511	ligase activity, forming carbon-carbon bonds
C380_19875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C380_19885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C380_19895	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C380_19905	COG0312	modulator of DNA gyrase
C380_19915	COG0772	Belongs to the SEDS family
C380_19920	COG2815	serine threonine protein kinase
C380_19920	COG0515	serine threonine protein kinase
C380_19925	COG3150	esterase
C380_19935	COG0557	exoribonuclease II activity
C380_19945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C380_19950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C380_19970	COG0575	Belongs to the CDS family
C380_19975	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C380_19990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C380_20025	COG1132	(ABC) transporter
C380_20030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C380_20030	COG0189	ligase activity
C380_20035	COG0189	ligase activity
C380_20035	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C380_20040	COG3045	CreA protein
C380_20045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C380_20050	COG1028	Short-chain dehydrogenase reductase Sdr
C380_20065	COG3290	protein histidine kinase activity
C380_20065	COG3829	transcription factor binding
C380_20070	COG0318	PFAM AMP-dependent synthetase and ligase
C380_20075	COG0183	Belongs to the thiolase family
C380_20105	COG1272	protein, Hemolysin III
C380_20115	COG0318	PFAM AMP-dependent synthetase and ligase
C380_20120	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_20130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C380_20200	COG0583	DNA-binding transcription factor activity
C380_20205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C380_20210	COG3002	Belongs to the UPF0753 family
C380_20220	COG3706	GGDEF domain
C380_20225	COG0596	Alpha beta hydrolase
C380_20230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C380_20235	COG1522	sequence-specific DNA binding
C380_20240	COG3706	GGDEF domain
C380_20245	COG2205	protein histidine kinase activity
C380_20250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C380_20265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C380_20285	COG0583	DNA-binding transcription factor activity
C380_20295	COG0739	heme binding
C380_20300	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C380_20305	COG2814	Major facilitator Superfamily
C380_20310	COG0316	Belongs to the HesB IscA family
C380_20325	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C380_20330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C380_20340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C380_20345	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C380_20360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C380_20365	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C380_20390	COG4154	Belongs to the RbsD FucU family
C380_20425	COG1522	sequence-specific DNA binding
C380_20440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C380_20445	COG0683	leucine binding
C380_20450	COG0683	leucine binding
C380_20500	COG0583	DNA-binding transcription factor activity
C380_20505	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_20510	COG3246	L-lysine catabolic process to acetate
C380_20515	COG3181	Tripartite tricarboxylate transporter family receptor
C380_20520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C380_20535	COG1024	Enoyl-CoA hydratase
C380_20540	COG2318	DinB family
C380_20545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C380_20550	COG0318	PFAM AMP-dependent synthetase and ligase
C380_20575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C380_20595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C380_20600	COG3012	SEC-C Motif Domain Protein
C380_20635	COG0642	Histidine kinase
C380_20645	COG1960	acyl-CoA dehydrogenase activity
C380_20660	COG0183	Belongs to the thiolase family
C380_20665	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C380_20670	COG0288	reversible hydration of carbon dioxide
C380_20675	COG1960	acyl-CoA dehydrogenase activity
C380_20695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C380_20695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C380_20705	COG2201	protein-glutamate methylesterase activity
C380_20710	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C380_20715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C380_20720	COG0835	chemotaxis
C380_20725	COG2198	Histidine kinase
C380_20725	COG0643	Histidine kinase
C380_20730	COG0835	chemotaxis
C380_20730	COG0784	Response regulator, receiver
C380_20745	COG2197	response regulator
C380_20755	COG1987	bacterial-type flagellum assembly
C380_20770	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C380_20780	COG1580	Controls the rotational direction of flagella during chemotaxis
C380_20840	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C380_20860	COG1360	Flagellar Motor Protein
C380_20865	COG0745	RESPONSE REGULATOR receiver
C380_20870	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C380_20875	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C380_20880	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C380_20895	COG1191	sigma factor activity
C380_20920	COG1558	bacterial-type flagellum-dependent cell motility
C380_20925	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C380_20930	COG1749	Flagellar hook protein flgE
C380_20935	COG4787	bacterial-type flagellum-dependent cell motility
C380_20940	COG4786	Flagellar basal body rod
C380_20945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C380_20950	COG1706	bacterial-type flagellum-dependent cell motility
C380_20960	COG1256	bacterial-type flagellum assembly
C380_20965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C380_20975	COG0436	Aminotransferase
C380_20985	COG0697	spore germination
C380_20995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C380_21000	COG0625	glutathione transferase activity
C380_21010	COG0384	phenazine biosynthesis protein PhzF
C380_21020	COG1280	lysine exporter protein (LysE YggA)
C380_21045	COG0318	PFAM AMP-dependent synthetase and ligase
C380_21050	COG1879	ABC-type sugar transport system periplasmic component
C380_21055	COG1129	ABC transporter
C380_21060	COG1172	Belongs to the binding-protein-dependent transport system permease family
C380_21070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C380_21075	COG1869	D-ribose catabolic process
C380_21095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C380_21100	COG0625	glutathione transferase activity
C380_21115	COG0617	tRNA 3'-terminal CCA addition
C380_21125	COG4944	Protein of unknown function (DUF1109)
C380_21130	COG1595	DNA-templated transcription, initiation
C380_21140	COG3220	belongs to the UPF0276 family
C380_21160	COG1877	trehalose-phosphatase activity
C380_21165	COG3387	PFAM Glycoside hydrolase 15-related
C380_21195	COG1012	belongs to the aldehyde dehydrogenase family
C380_21200	COG1028	Short-chain dehydrogenase reductase Sdr
C380_21205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_21215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_21240	COG1024	Enoyl-CoA hydratase
C380_21240	COG1250	3-hydroxyacyl-CoA dehydrogenase
C380_21245	COG0163	prenyltransferase activity
C380_21280	COG0583	DNA-binding transcription factor activity
C380_21290	COG0037	tRNA processing
C380_21315	COG2255	four-way junction helicase activity
C380_21330	COG0632	four-way junction helicase activity
C380_21335	COG1702	phosphate starvation-inducible protein PhoH
C380_21340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C380_21345	COG0730	response to heat
C380_21355	COG0589	response to stress
C380_21360	COG1490	D-aminoacyl-tRNA deacylase activity
C380_21365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C380_21370	COG4191	Histidine kinase
C380_21385	COG0666	response to abiotic stimulus
C380_21405	COG3181	Tripartite tricarboxylate transporter family receptor
C380_21410	COG2267	carboxylic ester hydrolase activity
C380_21420	COG0183	Belongs to the thiolase family
C380_21430	COG0513	Belongs to the DEAD box helicase family
C380_21445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C380_21475	COG4232	protein-disulfide reductase activity
C380_21480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C380_21485	COG1832	CoA-binding protein
C380_21495	COG1414	Transcriptional regulator
C380_21505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C380_21525	COG0861	Integral membrane protein TerC family
C380_21530	COG0583	DNA-binding transcription factor activity
C380_21550	COG2814	Major facilitator Superfamily
C380_21555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C380_21565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C380_21570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C380_21575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C380_21580	COG0405	Gamma-glutamyltransferase
C380_21590	COG0679	Auxin Efflux Carrier
C380_21600	COG0210	DNA helicase
C380_21625	COG0343	queuine tRNA-ribosyltransferase activity
C380_21680	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C380_21685	COG3181	Tripartite tricarboxylate transporter family receptor
C380_21690	COG0204	Acyl-transferase
C380_21690	COG0318	PFAM AMP-dependent synthetase and ligase
C380_21705	COG1309	transcriptional regulator
C380_21715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C380_21740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C380_21760	COG1253	flavin adenine dinucleotide binding
C380_21775	COG2847	Copper chaperone PCu(A)C
C380_21795	COG0625	glutathione transferase activity
C380_21815	COG2095	MarC family integral membrane protein
C380_21825	COG0583	DNA-binding transcription factor activity
C380_21830	COG0203	ribosomal protein L17
C380_21835	COG0202	RNA polymerase activity
C380_21840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C380_21845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C380_21850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C380_21855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C380_21860	COG0201	protein transport
C380_21865	COG0200	Binds to the 23S rRNA
C380_21870	COG1841	ribosomal large subunit assembly
C380_21875	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C380_21880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C380_21885	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C380_21890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C380_21895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C380_21900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C380_21905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C380_21910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C380_21915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C380_21930	COG0395	ABC-type sugar transport system, permease component
C380_21945	COG3842	ATPase activity
C380_21955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C380_21965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C380_21975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C380_21985	COG5002	protein histidine kinase activity
C380_21990	COG0745	RESPONSE REGULATOR receiver
C380_21995	COG0783	Belongs to the Dps family
C380_22010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C380_22025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C380_22045	COG0583	DNA-binding transcription factor activity
C380_22055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C380_22060	COG0134	indole-3-glycerol-phosphate synthase activity
C380_22070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C380_22075	COG1280	lysine exporter protein (LysE YggA)
C380_22080	COG0512	Glutamine amidotransferase of anthranilate synthase
C380_22105	COG0546	phosphoglycolate phosphatase activity
C380_22135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C380_22140	COG2967	ApaG domain
C380_22155	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C380_22170	COG1595	DNA-templated transcription, initiation
C380_22175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C380_22200	COG0589	response to stress
C380_22205	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C380_22210	COG1546	Belongs to the CinA family
C380_22215	COG0596	Alpha beta hydrolase
C380_22230	COG0653	protein targeting
C380_22235	COG0069	glutamate synthase activity
C380_22270	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C380_22275	COG1137	ATPase activity
C380_22285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C380_22295	COG0018	arginyl-trna synthetase
C380_22315	COG1301	dicarboxylic acid transport
C380_22320	COG4191	Histidine kinase
C380_22345	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C380_22355	COG1942	4-Oxalocrotonate Tautomerase
C380_22360	COG2814	Major facilitator Superfamily
C380_22365	COG0121	glutamine amidotransferase
C380_22370	COG0189	ligase activity
C380_22375	COG3135	benzoate transporter
C380_22380	COG3158	transport of potassium into the cell
C380_22390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C380_22395	COG0569	domain protein
C380_22400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C380_22430	COG0495	leucyl-tRNA aminoacylation
C380_22445	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C380_22450	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C380_22455	COG0735	belongs to the Fur family
C380_22460	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C380_22470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C380_22480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C380_22485	COG3118	belongs to the thioredoxin family
C380_22490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C380_22495	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C380_22500	COG0009	L-threonylcarbamoyladenylate synthase
C380_22540	COG4095	Psort location CytoplasmicMembrane, score
C380_22555	COG1214	PFAM Peptidase M22, glycoprotease
C380_22570	COG0598	Magnesium transport protein CorA
C380_22575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C380_22580	COG0318	PFAM AMP-dependent synthetase and ligase
C380_22585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C380_22590	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C380_22605	COG0642	Histidine kinase
C380_22610	COG0745	RESPONSE REGULATOR receiver
C380_22620	COG0671	phosphoesterase, PA-phosphatase related
C380_22625	COG0469	pyruvate kinase activity
C380_22635	COG0006	proline dipeptidase activity
C380_22645	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C380_22650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C380_22655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C380_22660	COG0668	transmembrane transport
C380_22675	COG0667	Aldo Keto reductase
C380_22690	COG0740	serine-type endopeptidase activity
C380_22725	COG2159	amidohydrolase
C380_22735	COG0583	DNA-binding transcription factor activity
C380_22765	COG4177	L-phenylalanine transmembrane transporter activity
C380_22795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C380_22830	COG0625	glutathione transferase activity
C380_22870	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C380_22880	COG2378	regulation of single-species biofilm formation
C380_22895	COG0300	oxidoreductase activity
C380_22900	COG0583	DNA-binding transcription factor activity
C380_22905	COG1028	Short-chain dehydrogenase reductase Sdr
C380_22930	COG0745	RESPONSE REGULATOR receiver
C380_22935	COG2205	protein histidine kinase activity
C380_22940	COG3284	Transcriptional regulator
C380_22945	COG1012	belongs to the aldehyde dehydrogenase family
C380_22955	COG0840	transmembrane signaling receptor activity
C380_22980	COG0583	DNA-binding transcription factor activity
C380_22985	COG0284	orotidine-5'-phosphate decarboxylase activity
C380_22990	COG0126	phosphoglycerate kinase activity
C380_23005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C380_23015	COG0242	peptide deformylase activity
C380_23025	COG0758	DNA mediated transformation
C380_23035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C380_23040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C380_23045	COG1862	Preprotein translocase
C380_23055	COG1522	sequence-specific DNA binding
C380_23085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C380_23095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C380_23110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C380_23140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C380_23180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C380_23185	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C380_23190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C380_23195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C380_23200	COG1309	transcriptional regulator
C380_23205	COG0625	glutathione transferase activity
C380_23215	COG4681	YaeQ
C380_23230	COG0861	Integral membrane protein TerC family
C380_23240	COG1950	PFAM Membrane protein of
C380_23245	COG4783	chaperone-mediated protein folding
C380_23250	COG0315	cyclic pyranopterin monophosphate synthase activity
C380_23290	COG2815	serine threonine protein kinase
C380_23290	COG0515	serine threonine protein kinase
C380_23295	COG0861	Integral membrane protein TerC family
C380_23300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C380_23305	COG0045	succinate-CoA ligase (ADP-forming) activity
C380_23310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C380_23315	COG2137	regulation of response to DNA damage stimulus
C380_23320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C380_23350	COG0642	Histidine kinase
C380_23380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C380_23380	COG0551	DNA topoisomerase type I activity
C380_23405	COG2365	Tyrosine phosphatase family
C380_23410	COG2814	Major facilitator Superfamily
C380_23415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C380_23460	COG2814	Major facilitator Superfamily
C380_23465	COG0629	single-stranded DNA binding
C380_23480	COG0482	sulfurtransferase activity
C380_23485	COG0583	DNA-binding transcription factor activity
C380_23490	COG2828	Protein conserved in bacteria
C380_23500	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C380_23505	COG1620	l-lactate permease
C380_23535	COG0583	DNA-binding transcription factor activity
C380_23545	COG1012	belongs to the aldehyde dehydrogenase family
C380_23550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C380_23595	COG2198	Histidine kinase
C380_23595	COG2205	protein histidine kinase activity
C380_23595	COG0784	Response regulator, receiver
C380_23600	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C380_23625	COG4786	Flagellar basal body rod
C380_23670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C380_23675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C380_23680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C380_23690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C380_23695	COG3706	GGDEF domain
C380_23725	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C380_23745	COG1272	protein, Hemolysin III
C380_23780	COG2267	carboxylic ester hydrolase activity
C380_23790	COG3706	GGDEF domain
C380_23790	COG5001	Diguanylate cyclase
C380_23790	COG4251	negative regulation of phosphorylation
C380_23790	COG2203	Gaf domain
C380_23795	COG0840	transmembrane signaling receptor activity
C380_23800	COG3622	Belongs to the hyi family
C380_23810	COG2813	Specifically methylates the guanine in position
C380_23810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C380_23815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C380_23820	COG2119	membrane
C380_23825	COG0724	RNA recognition motif
C380_23830	COG0724	RNA recognition motif
C380_23835	COG4221	oxidoreductase activity
C380_23845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C380_23850	COG0517	IMP dehydrogenase activity
C380_23850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C380_23865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C380_23880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C380_23895	COG0706	membrane insertase activity
C380_23900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C380_23905	COG0594	ribonuclease P activity
C380_23910	COG0230	Belongs to the bacterial ribosomal protein bL34 family