locus-tag	class	description
BSY15_1	COG3706	GGDEF domain
BSY15_1	COG0745	RESPONSE REGULATOR receiver
BSY15_10	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BSY15_1001	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BSY15_1004	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSY15_1005	COG1253	flavin adenine dinucleotide binding
BSY15_1008	COG2847	Copper chaperone PCu(A)C
BSY15_1012	COG0625	glutathione transferase activity
BSY15_1017	COG0583	DNA-binding transcription factor activity
BSY15_1019	COG0203	ribosomal protein L17
BSY15_1020	COG0202	RNA polymerase activity
BSY15_1021	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BSY15_1022	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BSY15_1023	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BSY15_1024	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BSY15_1025	COG0201	protein transport
BSY15_1026	COG0200	Binds to the 23S rRNA
BSY15_1027	COG1841	ribosomal large subunit assembly
BSY15_1028	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BSY15_1029	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BSY15_1030	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BSY15_1031	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BSY15_1032	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BSY15_1033	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BSY15_1034	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BSY15_1035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BSY15_1036	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BSY15_1039	COG0395	ABC-type sugar transport system, permease component
BSY15_1041	COG3842	ATPase activity
BSY15_1042	COG3842	ATPase activity
BSY15_1044	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BSY15_1046	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BSY15_1047	COG2205	protein histidine kinase activity
BSY15_1047	COG3437	response regulator, receiver
BSY15_1047	COG3850	Histidine kinase
BSY15_1047	COG4999	Histidine kinase
BSY15_1048	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BSY15_105	COG0431	NADPH-dependent FMN reductase
BSY15_1051	COG0745	RESPONSE REGULATOR receiver
BSY15_1052	COG0783	Belongs to the Dps family
BSY15_1054	COG3039	Transposase
BSY15_1055	COG0583	DNA-binding transcription factor activity
BSY15_1056	COG0583	DNA-binding transcription factor activity
BSY15_1059	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BSY15_106	COG0798	PFAM Bile acid sodium symporter
BSY15_1062	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BSY15_1065	COG0583	DNA-binding transcription factor activity
BSY15_1067	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BSY15_1068	COG0134	indole-3-glycerol-phosphate synthase activity
BSY15_1070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BSY15_1071	COG1280	lysine exporter protein (LysE YggA)
BSY15_1072	COG0512	Glutamine amidotransferase of anthranilate synthase
BSY15_1076	COG0546	phosphoglycolate phosphatase activity
BSY15_1077	COG0840	transmembrane signaling receptor activity
BSY15_108	COG0640	Transcriptional regulator
BSY15_1083	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BSY15_1085	COG2967	ApaG domain
BSY15_1088	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BSY15_1098	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BSY15_1100	COG0596	Alpha beta hydrolase
BSY15_1103	COG0659	secondary active sulfate transmembrane transporter activity
BSY15_1104	COG3012	SEC-C Motif Domain Protein
BSY15_1104	COG3318	Belongs to the UPF0149 family
BSY15_1105	COG0069	glutamate synthase activity
BSY15_1112	COG0840	transmembrane signaling receptor activity
BSY15_1115	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BSY15_1116	COG1137	ATPase activity
BSY15_1118	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BSY15_1120	COG0018	arginyl-trna synthetase
BSY15_1124	COG0583	DNA-binding transcription factor activity
BSY15_1125	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BSY15_1127	COG1942	4-Oxalocrotonate Tautomerase
BSY15_1128	COG2814	Major facilitator Superfamily
BSY15_1130	COG2801	Transposase and inactivated derivatives
BSY15_1131	COG0121	glutamine amidotransferase
BSY15_1137	COG0189	ligase activity
BSY15_1138	COG3135	benzoate transporter
BSY15_1139	COG3158	transport of potassium into the cell
BSY15_1141	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BSY15_1142	COG0569	domain protein
BSY15_1143	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BSY15_1144	COG2194	sulfuric ester hydrolase activity
BSY15_1150	COG0495	leucyl-tRNA aminoacylation
BSY15_1154	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BSY15_1155	COG0735	belongs to the Fur family
BSY15_1156	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BSY15_1158	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BSY15_1159	COG2814	Major facilitator Superfamily
BSY15_1160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BSY15_1161	COG3126	Type III secretion system lipoprotein chaperone (YscW)
BSY15_1162	COG3118	belongs to the thioredoxin family
BSY15_1163	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BSY15_1164	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BSY15_1165	COG0009	L-threonylcarbamoyladenylate synthase
BSY15_1169	COG2027	D-alanyl-D-alanine carboxypeptidase
BSY15_1175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BSY15_1176	COG0318	PFAM AMP-dependent synthetase and ligase
BSY15_1177	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BSY15_1178	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BSY15_1182	COG0745	RESPONSE REGULATOR receiver
BSY15_1186	COG0006	proline dipeptidase activity
BSY15_1187	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BSY15_1188	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BSY15_1189	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BSY15_1190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BSY15_1191	COG0668	transmembrane transport
BSY15_1194	COG0667	Aldo Keto reductase
BSY15_1197	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BSY15_1198	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BSY15_1199	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BSY15_12	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BSY15_1200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BSY15_1201	COG1309	transcriptional regulator
BSY15_1206	COG3181	Tripartite tricarboxylate transporter family receptor
BSY15_1208	COG2159	amidohydrolase
BSY15_1210	COG0583	DNA-binding transcription factor activity
BSY15_1211	COG3135	benzoate transporter
BSY15_1214	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BSY15_1215	COG2814	Major facilitator Superfamily
BSY15_1220	COG3485	protocatechuate 3,4-dioxygenase
BSY15_1223	COG3181	Tripartite tricarboxylate transporter family receptor
BSY15_1224	COG0410	ABC transporter
BSY15_1233	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BSY15_1235	COG1335	isochorismatase
BSY15_1236	COG0583	DNA-binding transcription factor activity
BSY15_1241	COG0745	RESPONSE REGULATOR receiver
BSY15_1242	COG1047	Peptidyl-prolyl cis-trans
BSY15_1250	COG0300	oxidoreductase activity
BSY15_1257	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BSY15_1260	COG2094	Belongs to the DNA glycosylase MPG family
BSY15_1261	COG2365	Tyrosine phosphatase family
BSY15_1265	COG1881	PFAM PEBP family protein
BSY15_1268	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BSY15_1268	COG0551	DNA topoisomerase type I activity
BSY15_1273	COG0642	Histidine kinase
BSY15_1276	COG3181	Tripartite tricarboxylate transporter family receptor
BSY15_1279	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BSY15_1280	COG2137	regulation of response to DNA damage stimulus
BSY15_1281	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BSY15_1282	COG0045	succinate-CoA ligase (ADP-forming) activity
BSY15_1283	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BSY15_1284	COG2815	serine threonine protein kinase
BSY15_1284	COG0515	serine threonine protein kinase
BSY15_1286	COG1716	ATPase activity
BSY15_1289	COG2801	Transposase and inactivated derivatives
BSY15_1291	COG1950	PFAM Membrane protein of
BSY15_1292	COG4783	chaperone-mediated protein folding
BSY15_1294	COG0861	Integral membrane protein TerC family
BSY15_1297	COG4681	YaeQ
BSY15_1299	COG0625	glutathione transferase activity
BSY15_13	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BSY15_1301	COG0300	oxidoreductase activity
BSY15_1305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BSY15_1314	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BSY15_1316	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BSY15_1321	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSY15_1321	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSY15_1322	COG2814	Major facilitator Superfamily
BSY15_1323	COG1522	sequence-specific DNA binding
BSY15_1326	COG1862	Preprotein translocase
BSY15_1327	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BSY15_1328	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BSY15_1332	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BSY15_1335	COG0724	RNA recognition motif
BSY15_1336	COG0724	RNA recognition motif
BSY15_1337	COG2119	membrane
BSY15_1338	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BSY15_1339	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BSY15_1339	COG2813	Specifically methylates the guanine in position
BSY15_134	COG2721	sulfolactate sulfo-lyase activity
BSY15_1341	COG3622	Belongs to the hyi family
BSY15_1342	COG3706	GGDEF domain
BSY15_1342	COG0745	RESPONSE REGULATOR receiver
BSY15_1344	COG2267	carboxylic ester hydrolase activity
BSY15_1354	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BSY15_136	COG4948	Mandelate Racemase Muconate Lactonizing
BSY15_1368	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BSY15_1369	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BSY15_1370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BSY15_1372	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BSY15_1373	COG3706	GGDEF domain
BSY15_1374	COG0745	RESPONSE REGULATOR receiver
BSY15_1374	COG3706	GGDEF domain
BSY15_1378	COG3039	Transposase
BSY15_1380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BSY15_1381	COG0163	prenyltransferase activity
BSY15_1384	COG1272	protein, Hemolysin III
BSY15_1387	COG2814	Major facilitator Superfamily
BSY15_1388	COG0482	sulfurtransferase activity
BSY15_1389	COG0629	single-stranded DNA binding
BSY15_139	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BSY15_1390	COG2814	Major facilitator Superfamily
BSY15_1398	COG0745	RESPONSE REGULATOR receiver
BSY15_14	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSY15_140	COG1802	Transcriptional regulator
BSY15_1400	COG3284	Transcriptional regulator
BSY15_1401	COG1012	belongs to the aldehyde dehydrogenase family
BSY15_1408	COG0840	transmembrane signaling receptor activity
BSY15_1413	COG0583	DNA-binding transcription factor activity
BSY15_1414	COG0284	orotidine-5'-phosphate decarboxylase activity
BSY15_1417	COG0126	phosphoglycerate kinase activity
BSY15_1420	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BSY15_1422	COG0242	peptide deformylase activity
BSY15_1424	COG0758	DNA mediated transformation
BSY15_1426	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BSY15_1428	COG2066	Belongs to the glutaminase family
BSY15_1428	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BSY15_1429	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BSY15_1430	COG0706	membrane insertase activity
BSY15_1431	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BSY15_1432	COG0594	ribonuclease P activity
BSY15_1433	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BSY15_1434	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BSY15_1439	COG3039	Transposase
BSY15_1450	COG1764	response to oxidative stress
BSY15_1452	COG0318	PFAM AMP-dependent synthetase and ligase
BSY15_1457	COG0745	RESPONSE REGULATOR receiver
BSY15_1458	COG2205	protein histidine kinase activity
BSY15_1466	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BSY15_1467	COG1518	maintenance of DNA repeat elements
BSY15_1475	COG1199	ATP-dependent helicase activity
BSY15_1476	COG2824	Alkylphosphonate utilization operon protein PhnA
BSY15_148	COG0410	ABC transporter
BSY15_1480	COG1199	ATP-dependent helicase activity
BSY15_1480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BSY15_1487	COG0791	NLP P60 protein
BSY15_1488	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BSY15_149	COG0411	ABC transporter
BSY15_1490	COG0789	Transcriptional regulator
BSY15_1494	COG2974	May be involved in recombination
BSY15_1495	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BSY15_1495	COG2755	lipolytic protein G-D-S-L family
BSY15_15	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BSY15_150	COG4733	cellulase activity
BSY15_150	COG5297	Belongs to the glycosyl hydrolase family 6
BSY15_1507	COG0840	transmembrane signaling receptor activity
BSY15_1509	COG1902	pentaerythritol trinitrate reductase activity
BSY15_1511	COG0625	glutathione transferase activity
BSY15_1513	COG0583	DNA-binding transcription factor activity
BSY15_1514	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BSY15_152	COG2204	response regulator
BSY15_1522	COG0445	tRNA wobble uridine modification
BSY15_1523	COG0357	Ribosomal RNA small subunit methyltransferase G
BSY15_1525	COG1192	Involved in chromosome partitioning
BSY15_1529	COG1475	DNA binding
BSY15_1531	COG2963	transposase activity
BSY15_1532	COG3039	Transposase
BSY15_1539	COG0596	Alpha beta hydrolase
BSY15_1541	COG5002	protein histidine kinase activity
BSY15_1541	COG5001	Diguanylate cyclase
BSY15_1546	COG1522	sequence-specific DNA binding
BSY15_1551	COG1201	RNA secondary structure unwinding
BSY15_1552	COG1793	dna ligase
BSY15_1553	COG1793	dna ligase
BSY15_1553	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BSY15_1555	COG1742	UPF0060 membrane protein
BSY15_1556	COG3706	GGDEF domain
BSY15_1557	COG0277	FAD linked oxidase domain protein
BSY15_1559	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BSY15_1560	COG0765	amino acid transport
BSY15_1561	COG0765	amino acid transport
BSY15_1562	COG1126	abc transporter atp-binding protein
BSY15_1565	COG2096	Adenosyltransferase
BSY15_1566	COG2050	protein possibly involved in aromatic compounds catabolism
BSY15_1568	COG2233	PERMEase
BSY15_1574	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BSY15_1577	COG0366	Alpha amylase catalytic
BSY15_1578	COG0366	Alpha amylase catalytic
BSY15_1579	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BSY15_1581	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BSY15_1583	COG0318	PFAM AMP-dependent synthetase and ligase
BSY15_1584	COG1183	phosphatidylcholine synthase activity
BSY15_159	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BSY15_1590	COG0850	regulation of cytokinetic process
BSY15_1592	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BSY15_1594	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BSY15_1597	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BSY15_1598	COG1309	transcriptional regulator
BSY15_160	COG0582	viral genome integration into host DNA
BSY15_1600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSY15_1603	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BSY15_1604	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BSY15_1609	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BSY15_1610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BSY15_1612	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BSY15_1614	COG0724	RNA recognition motif
BSY15_1616	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BSY15_1617	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BSY15_1618	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BSY15_1619	COG0277	FAD linked oxidase domain protein
BSY15_1623	COG0583	DNA-binding transcription factor activity
BSY15_1625	COG0037	tRNA processing
BSY15_1628	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BSY15_1629	COG2326	polyphosphate kinase activity
BSY15_163	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BSY15_1632	COG1410	methionine synthase
BSY15_1632	COG0646	methionine synthase
BSY15_1635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BSY15_1637	COG0559	Belongs to the binding-protein-dependent transport system permease family
BSY15_1649	COG0683	leucine binding
BSY15_165	COG4983	Phage plasmid primase, P4 family domain protein
BSY15_1653	COG1673	EVE domain
BSY15_1658	COG1960	acyl-CoA dehydrogenase activity
BSY15_1662	COG1024	Enoyl-CoA hydratase
BSY15_1665	COG0606	chelatase, subunit chli
BSY15_1668	COG0004	ammonium transporteR
BSY15_1669	COG0277	FAD linked oxidase domain protein
BSY15_1671	COG0247	lactate metabolic process
BSY15_1679	COG0386	Belongs to the glutathione peroxidase family
BSY15_1681	COG3039	Transposase
BSY15_1683	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BSY15_1687	COG0747	negative chemotaxis
BSY15_1688	COG0625	glutathione transferase activity
BSY15_1689	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BSY15_169	COG0037	tRNA processing
BSY15_1694	COG0438	transferase activity, transferring glycosyl groups
BSY15_1701	COG0477	Major facilitator Superfamily
BSY15_1702	COG2205	protein histidine kinase activity
BSY15_1703	COG0745	RESPONSE REGULATOR receiver
BSY15_1704	COG2211	Major facilitator Superfamily
BSY15_1707	COG2909	trisaccharide binding
BSY15_1708	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSY15_171	COG0825	malonyl-CoA metabolic process
BSY15_1710	COG0708	Exodeoxyribonuclease III
BSY15_1711	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BSY15_1713	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BSY15_1714	COG0154	amidase activity
BSY15_1715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BSY15_1716	COG1077	Cell shape determining protein MreB Mrl
BSY15_1718	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BSY15_1719	COG0768	penicillin binding
BSY15_1723	COG0765	amino acid transport
BSY15_1724	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSY15_1727	COG0583	DNA-binding transcription factor activity
BSY15_1728	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BSY15_1729	COG1127	ABC transporter
BSY15_173	COG0215	cysteine-tRNA ligase activity
BSY15_1734	COG3237	CsbD-like
BSY15_1738	COG4452	Inner membrane protein CreD
BSY15_1740	COG2205	protein histidine kinase activity
BSY15_1741	COG0745	RESPONSE REGULATOR receiver
BSY15_1742	COG2095	MarC family integral membrane protein
BSY15_1743	COG0412	Dienelactone hydrolase
BSY15_1744	COG3039	Transposase
BSY15_1746	COG0840	transmembrane signaling receptor activity
BSY15_1747	COG0598	Magnesium transport protein CorA
BSY15_1752	COG2945	thiolester hydrolase activity
BSY15_1753	COG1686	Belongs to the peptidase S11 family
BSY15_1754	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BSY15_1755	COG0049	tRNA binding
BSY15_1756	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BSY15_1757	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BSY15_1758	COG0051	transcription antitermination factor activity, RNA binding
BSY15_1759	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BSY15_1760	COG0088	Forms part of the polypeptide exit tunnel
BSY15_1761	COG0089	rRNA binding
BSY15_1762	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BSY15_1763	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BSY15_1764	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BSY15_1765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BSY15_1766	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BSY15_1767	COG0255	Belongs to the universal ribosomal protein uL29 family
BSY15_1768	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BSY15_1769	COG0678	peroxiredoxin activity
BSY15_1772	COG3909	cytochrome
BSY15_1773	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSY15_1777	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSY15_1778	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BSY15_178	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BSY15_1781	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BSY15_1782	COG0321	lipoyl(octanoyl) transferase activity
BSY15_1783	COG2921	Belongs to the UPF0250 family
BSY15_1785	COG0356	it plays a direct role in the translocation of protons across the membrane
BSY15_1787	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BSY15_1788	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BSY15_1789	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BSY15_179	COG3228	Belongs to the MtfA family
BSY15_1790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BSY15_1791	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BSY15_1792	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BSY15_18	COG4206	TonB-dependent receptor
BSY15_1800	COG1538	Outer membrane efflux protein
BSY15_1802	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSY15_1803	COG1309	transcriptional regulator
BSY15_1808	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BSY15_1810	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BSY15_1812	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BSY15_1813	COG0081	regulation of translation
BSY15_1814	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BSY15_1815	COG0222	ribosome binding
BSY15_1816	COG0085	RNA polymerase activity
BSY15_1817	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BSY15_1819	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BSY15_1819	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BSY15_182	COG1522	sequence-specific DNA binding
BSY15_1821	COG5000	phosphorelay sensor kinase activity
BSY15_1822	COG2204	response regulator
BSY15_1824	COG0443	Heat shock 70 kDa protein
BSY15_1825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BSY15_1826	COG0792	nuclease activity
BSY15_1827	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BSY15_1828	COG2823	Periplasmic or secreted lipoprotein
BSY15_1829	COG2084	Dehydrogenase
BSY15_1831	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BSY15_1833	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BSY15_1835	COG4770	biotin carboxylase activity
BSY15_1837	COG2733	membrane
BSY15_1839	COG1346	cytolysis
BSY15_184	COG3384	dioxygenase
BSY15_1840	COG1380	Effector of murein hydrolase LrgA
BSY15_1841	COG0277	FAD linked oxidase domain protein
BSY15_1842	COG0583	DNA-binding transcription factor activity
BSY15_1847	COG2197	response regulator
BSY15_1849	COG2223	nitrite transmembrane transporter activity
BSY15_1850	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BSY15_1851	COG1140	nitrate reductase beta subunit
BSY15_1852	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BSY15_1853	COG2181	nitrate reductase activity
BSY15_1854	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BSY15_1855	COG0288	reversible hydration of carbon dioxide
BSY15_1856	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BSY15_186	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BSY15_1860	COG3945	hemerythrin HHE cation binding domain
BSY15_1866	COG1979	alcohol dehydrogenase
BSY15_1868	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BSY15_1870	COG3039	Transposase
BSY15_1871	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BSY15_1872	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BSY15_1873	COG4804	nuclease activity
BSY15_1875	COG0243	molybdopterin cofactor binding
BSY15_1878	COG1473	amidohydrolase
BSY15_188	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BSY15_1880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BSY15_1882	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BSY15_1884	COG2423	ornithine cyclodeaminase activity
BSY15_189	COG3039	Transposase
BSY15_1890	COG0431	NADPH-dependent FMN reductase
BSY15_1892	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
BSY15_1893	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
BSY15_1894	COG1609	Transcriptional regulator
BSY15_1895	COG3624	Phosphonate C-P lyase system protein PhnG
BSY15_1897	COG3626	phosphonate metabolism
BSY15_1898	COG3627	carbon phosphorus lyase activity
BSY15_1900	COG4107	phosphonate C-P lyase system protein PhnK
BSY15_1901	COG4778	phosphonate C-P lyase system protein PhnL
BSY15_1902	COG3454	Phosphonate metabolism
BSY15_1903	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BSY15_1904	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BSY15_1905	COG3639	organic phosphonate transmembrane transporter activity
BSY15_1908	COG0697	spore germination
BSY15_1910	COG0251	oxidation-reduction process
BSY15_1912	COG1960	acyl-CoA dehydrogenase activity
BSY15_1913	COG1024	Enoyl-CoA hydratase
BSY15_1924	COG0559	Belongs to the binding-protein-dependent transport system permease family
BSY15_1927	COG3267	Type II secretory pathway component ExeA
BSY15_1927	COG3409	Peptidoglycan-binding domain 1 protein
BSY15_1930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BSY15_1931	COG0840	transmembrane signaling receptor activity
BSY15_1935	COG1187	pseudouridine synthase activity
BSY15_1938	COG0326	Molecular chaperone. Has ATPase activity
BSY15_1941	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSY15_1943	COG2815	serine threonine protein kinase
BSY15_1943	COG0515	serine threonine protein kinase
BSY15_1945	COG1764	response to oxidative stress
BSY15_1946	COG1846	Transcriptional regulator
BSY15_1947	COG1024	Enoyl-CoA hydratase
BSY15_1948	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSY15_1950	COG0842	Transport permease protein
BSY15_1951	COG3851	Histidine kinase
BSY15_1953	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSY15_1954	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSY15_1955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSY15_1955	COG1116	anion transmembrane transporter activity
BSY15_1956	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BSY15_1958	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BSY15_1959	COG1131	(ABC) transporter
BSY15_1960	COG3706	GGDEF domain
BSY15_1960	COG0745	RESPONSE REGULATOR receiver
BSY15_1961	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BSY15_1963	COG0513	Belongs to the DEAD box helicase family
BSY15_1967	COG4191	Histidine kinase
BSY15_1968	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BSY15_1969	COG1490	D-aminoacyl-tRNA deacylase activity
BSY15_1971	COG0730	response to heat
BSY15_1972	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BSY15_1973	COG1702	phosphate starvation-inducible protein PhoH
BSY15_1974	COG0632	four-way junction helicase activity
BSY15_1977	COG2255	four-way junction helicase activity
BSY15_1979	COG4591	ABC-type transport system involved in lipoprotein release permease component
BSY15_1980	COG1136	(ABC) transporter
BSY15_1985	COG0037	tRNA processing
BSY15_1987	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_1991	COG1877	trehalose-phosphatase activity
BSY15_1992	COG3118	belongs to the thioredoxin family
BSY15_1994	COG0617	tRNA 3'-terminal CCA addition
BSY15_1997	COG0745	RESPONSE REGULATOR receiver
BSY15_1998	COG0745	RESPONSE REGULATOR receiver
BSY15_1999	COG3300	MHYT domain
BSY15_1999	COG5001	Diguanylate cyclase
BSY15_2000	COG0840	transmembrane signaling receptor activity
BSY15_2001	COG0745	RESPONSE REGULATOR receiver
BSY15_2002	COG0745	RESPONSE REGULATOR receiver
BSY15_2004	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BSY15_2005	COG0739	heme binding
BSY15_2005	COG0741	lytic transglycosylase activity
BSY15_2005	COG1196	nuclear chromosome segregation
BSY15_2007	COG0318	PFAM AMP-dependent synthetase and ligase
BSY15_2010	COG3186	Phenylalanine-4-hydroxylase
BSY15_2013	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BSY15_2014	COG1522	sequence-specific DNA binding
BSY15_2017	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BSY15_2018	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BSY15_202	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BSY15_2020	COG0583	DNA-binding transcription factor activity
BSY15_2022	COG0752	glycyl-tRNA synthetase alpha subunit
BSY15_2023	COG0751	glycine-tRNA ligase activity
BSY15_2024	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BSY15_2028	COG1652	LysM domain
BSY15_2029	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BSY15_2033	COG4221	oxidoreductase activity
BSY15_2035	COG1091	dTDP-4-dehydrorhamnose reductase activity
BSY15_2036	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BSY15_2039	COG1216	Glycosyl transferase, family 2
BSY15_2040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BSY15_2041	COG1459	type II secretion system
BSY15_2046	COG3156	type II secretion system protein K
BSY15_2050	COG1450	Type ii and iii secretion system protein
BSY15_2058	COG1088	dTDP-glucose 4,6-dehydratase activity
BSY15_2062	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BSY15_2064	COG0739	heme binding
BSY15_2064	COG0741	lytic transglycosylase activity
BSY15_2064	COG1196	nuclear chromosome segregation
BSY15_2066	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BSY15_2067	COG0745	RESPONSE REGULATOR receiver
BSY15_2068	COG0642	Histidine kinase
BSY15_2069	COG1309	transcriptional regulator
BSY15_207	COG1525	nuclease
BSY15_2071	COG1960	acyl-CoA dehydrogenase activity
BSY15_2073	COG1024	Enoyl-CoA hydratase
BSY15_2073	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSY15_2075	COG0183	Belongs to the thiolase family
BSY15_2078	COG1024	Enoyl-CoA hydratase
BSY15_2081	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_2082	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BSY15_2083	COG4335	DNA alkylation repair
BSY15_2084	COG1960	acyl-CoA dehydrogenase activity
BSY15_2085	COG1024	Enoyl-CoA hydratase
BSY15_2087	COG1960	acyl-CoA dehydrogenase activity
BSY15_2088	COG3246	L-lysine catabolic process to acetate
BSY15_2091	COG0183	Belongs to the thiolase family
BSY15_2093	COG1960	acyl-CoA dehydrogenase activity
BSY15_2097	COG0411	ABC transporter
BSY15_2098	COG1172	Belongs to the binding-protein-dependent transport system permease family
BSY15_2099	COG0559	Belongs to the binding-protein-dependent transport system permease family
BSY15_21	COG0730	response to heat
BSY15_2100	COG2050	protein possibly involved in aromatic compounds catabolism
BSY15_2102	COG1607	acyl-coa hydrolase
BSY15_2103	COG5265	(ABC) transporter
BSY15_2104	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BSY15_2106	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BSY15_2109	COG0583	DNA-binding transcription factor activity
BSY15_211	COG0564	pseudouridine synthase activity
BSY15_2112	COG0765	amino acid transport
BSY15_2113	COG0765	amino acid transport
BSY15_2114	COG1126	abc transporter atp-binding protein
BSY15_2115	COG0418	dihydroorotase activity
BSY15_2117	COG0501	Belongs to the peptidase M48B family
BSY15_2121	COG0583	DNA-binding transcription factor activity
BSY15_2122	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BSY15_2123	COG0392	lysyltransferase activity
BSY15_2125	COG3568	Endonuclease Exonuclease Phosphatase
BSY15_213	COG1285	pathogenesis
BSY15_2130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSY15_2131	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BSY15_2133	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BSY15_2135	COG0840	transmembrane signaling receptor activity
BSY15_2136	COG0840	transmembrane signaling receptor activity
BSY15_2137	COG0835	chemotaxis
BSY15_2140	COG0523	cobalamin synthesis protein
BSY15_2141	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BSY15_2143	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BSY15_2144	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BSY15_2145	COG2001	Belongs to the MraZ family
BSY15_2146	COG0275	rRNA processing
BSY15_2149	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BSY15_2150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BSY15_2151	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BSY15_2152	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BSY15_2153	COG0772	Belongs to the SEDS family
BSY15_2154	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BSY15_2155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BSY15_2156	COG1181	Belongs to the D-alanine--D-alanine ligase family
BSY15_2157	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BSY15_2159	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BSY15_2160	COG0840	transmembrane signaling receptor activity
BSY15_2161	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BSY15_2163	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BSY15_2164	COG0840	transmembrane signaling receptor activity
BSY15_2178	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BSY15_2179	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BSY15_2180	COG1765	OsmC-like protein
BSY15_2181	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BSY15_2185	COG1473	amidohydrolase
BSY15_2186	COG0747	negative chemotaxis
BSY15_2187	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BSY15_2188	COG0444	Belongs to the ABC transporter superfamily
BSY15_2189	COG4608	Belongs to the ABC transporter superfamily
BSY15_2190	COG0737	Belongs to the 5'-nucleotidase family
BSY15_2191	COG0583	DNA-binding transcription factor activity
BSY15_2192	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSY15_2192	COG1024	Enoyl-CoA hydratase
BSY15_2193	COG0183	Belongs to the thiolase family
BSY15_2194	COG1960	acyl-CoA dehydrogenase activity
BSY15_2195	COG1960	acyl-CoA dehydrogenase activity
BSY15_2196	COG1024	Enoyl-CoA hydratase
BSY15_2197	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BSY15_2200	COG0318	PFAM AMP-dependent synthetase and ligase
BSY15_2205	COG1840	ABC-type Fe3 transport system, periplasmic component
BSY15_2207	COG3842	ATPase activity
BSY15_2208	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BSY15_2213	COG0297	glycogen (starch) synthase activity
BSY15_2214	COG1640	4-alpha-glucanotransferase
BSY15_2217	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BSY15_2218	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BSY15_222	COG2072	flavoprotein involved in K transport
BSY15_2220	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_2227	COG3706	GGDEF domain
BSY15_2232	COG3045	CreA protein
BSY15_2235	COG1132	(ABC) transporter
BSY15_2242	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSY15_2243	COG0501	Belongs to the peptidase M48B family
BSY15_2244	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BSY15_2245	COG0575	Belongs to the CDS family
BSY15_2249	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSY15_225	COG2267	carboxylic ester hydrolase activity
BSY15_2250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BSY15_2252	COG0557	exoribonuclease II activity
BSY15_2254	COG3150	esterase
BSY15_2255	COG2815	serine threonine protein kinase
BSY15_2255	COG0515	serine threonine protein kinase
BSY15_2256	COG0772	Belongs to the SEDS family
BSY15_2257	COG0312	modulator of DNA gyrase
BSY15_2259	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BSY15_2261	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BSY15_2263	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSY15_2264	COG0511	ligase activity, forming carbon-carbon bonds
BSY15_2265	COG0439	Biotin carboxylase
BSY15_2266	COG2264	protein methyltransferase activity
BSY15_227	COG2918	glutathione biosynthetic process
BSY15_2270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BSY15_2276	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BSY15_2277	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BSY15_2278	COG3416	Protein conserved in bacteria
BSY15_2278	COG2943	transferase activity, transferring hexosyl groups
BSY15_2279	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BSY15_228	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_2280	COG2204	response regulator
BSY15_2282	COG2205	protein histidine kinase activity
BSY15_2283	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BSY15_2286	COG1024	Enoyl-CoA hydratase
BSY15_2288	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BSY15_2289	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BSY15_2291	COG0012	GTP binding
BSY15_2292	COG3706	GGDEF domain
BSY15_2293	COG1238	metal cluster binding
BSY15_2295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BSY15_2296	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BSY15_2297	COG0138	bifunctional purine biosynthesis protein purh
BSY15_2298	COG4654	Cytochrome c, class I
BSY15_2299	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BSY15_23	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BSY15_23	COG2199	diguanylate cyclase activity
BSY15_2300	COG1414	Transcriptional regulator
BSY15_2301	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BSY15_2305	COG0835	chemotaxis
BSY15_2306	COG0840	transmembrane signaling receptor activity
BSY15_2309	COG0415	Belongs to the DNA photolyase family
BSY15_231	COG0633	Ferredoxin
BSY15_2310	COG1678	Uncharacterized ACR, COG1678
BSY15_2311	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BSY15_2312	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BSY15_2313	COG0540	Belongs to the ATCase OTCase family
BSY15_2316	COG4772	TonB-dependent receptor
BSY15_2317	COG3842	ATPase activity
BSY15_2318	COG1178	ABC-type Fe3 transport system permease component
BSY15_2320	COG5002	protein histidine kinase activity
BSY15_2320	COG0784	Response regulator, receiver
BSY15_2320	COG2205	protein histidine kinase activity
BSY15_2322	COG5006	permease, DMT superfamily
BSY15_233	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BSY15_2330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BSY15_2332	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BSY15_2336	COG1414	Transcriptional regulator
BSY15_2338	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BSY15_2339	COG0183	Belongs to the thiolase family
BSY15_234	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BSY15_2346	COG2860	membrane
BSY15_2348	COG1280	lysine exporter protein (LysE YggA)
BSY15_235	COG0436	Aminotransferase
BSY15_2351	COG0583	DNA-binding transcription factor activity
BSY15_2352	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BSY15_2353	COG1040	competence protein
BSY15_2354	COG2226	methyltransferase
BSY15_2357	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BSY15_2359	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BSY15_236	COG0824	Thioesterase
BSY15_2365	COG1612	heme a metabolic process
BSY15_2366	COG0109	protoheme IX farnesyltransferase activity
BSY15_2367	COG1999	signal sequence binding
BSY15_2368	COG3181	Tripartite tricarboxylate transporter family receptor
BSY15_2369	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BSY15_2371	COG1324	tolerance protein
BSY15_2373	COG0612	Peptidase, M16
BSY15_2374	COG0612	Peptidase, M16
BSY15_2375	COG0742	ribosomal rna small subunit methyltransferase
BSY15_2376	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BSY15_2377	COG0583	DNA-binding transcription factor activity
BSY15_2378	COG0019	diaminopimelate decarboxylase activity
BSY15_2379	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BSY15_2380	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BSY15_2383	COG0588	phosphoglycerate mutase activity
BSY15_2384	COG0793	Belongs to the peptidase S41A family
BSY15_2385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BSY15_2387	COG2197	response regulator
BSY15_2393	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BSY15_2394	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BSY15_2396	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BSY15_240	COG0477	Major facilitator Superfamily
BSY15_2402	COG2197	response regulator
BSY15_2403	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BSY15_2404	COG0720	synthase
BSY15_2405	COG0602	queuosine metabolic process
BSY15_2406	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BSY15_241	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BSY15_2412	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSY15_2412	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSY15_2416	COG0489	protein tyrosine kinase activity
BSY15_2417	COG0583	DNA-binding transcription factor activity
BSY15_2419	COG3383	formate dehydrogenase (NAD+) activity
BSY15_242	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BSY15_2425	COG0243	molybdopterin cofactor binding
BSY15_2425	COG3383	formate dehydrogenase (NAD+) activity
BSY15_2426	COG0437	4 iron, 4 sulfur cluster binding
BSY15_243	COG1845	cytochrome c oxidase, subunit III
BSY15_2430	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BSY15_2432	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BSY15_2433	COG2346	COG2346, Truncated hemoglobins
BSY15_2435	COG1193	negative regulation of DNA recombination
BSY15_2437	COG2003	Belongs to the UPF0758 family
BSY15_2438	COG1047	Peptidyl-prolyl cis-trans
BSY15_2439	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BSY15_244	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BSY15_2440	COG3039	Transposase
BSY15_2442	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BSY15_2443	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BSY15_2444	COG0709	Synthesizes selenophosphate from selenide and ATP
BSY15_2445	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BSY15_245	COG3346	SURF1 family
BSY15_2458	COG0514	ATP-dependent DNA helicase (RecQ)
BSY15_246	COG2205	protein histidine kinase activity
BSY15_2460	COG1431	PFAM Stem cell self-renewal protein Piwi
BSY15_2461	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BSY15_2464	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BSY15_2465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSY15_247	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BSY15_2474	COG0582	viral genome integration into host DNA
BSY15_2475	COG3339	Conserved Protein
BSY15_2479	COG0583	DNA-binding transcription factor activity
BSY15_2480	COG2801	Transposase and inactivated derivatives
BSY15_2481	COG2801	Transposase and inactivated derivatives
BSY15_2488	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BSY15_2493	COG0583	DNA-binding transcription factor activity
BSY15_2496	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BSY15_2499	COG0745	RESPONSE REGULATOR receiver
BSY15_2500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BSY15_2502	COG0180	Tryptophanyl-tRNA synthetase
BSY15_2503	COG1994	Peptidase M50
BSY15_2505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BSY15_2505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BSY15_2507	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BSY15_2508	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BSY15_2509	COG0492	ferredoxin-NADP+ reductase activity
BSY15_2510	COG1674	ftsk spoiiie
BSY15_2511	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BSY15_2512	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BSY15_2513	COG0559	Belongs to the binding-protein-dependent transport system permease family
BSY15_2518	COG1392	Phosphate transport regulator
BSY15_2519	COG0306	phosphate transporter
BSY15_252	COG0039	L-malate dehydrogenase activity
BSY15_2522	COG0228	four-way junction DNA binding
BSY15_2523	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BSY15_2524	COG0336	Belongs to the RNA methyltransferase TrmD family
BSY15_2525	COG0335	large ribosomal subunit rRNA binding
BSY15_2526	COG0494	nUDIX hydrolase
BSY15_2527	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BSY15_2528	COG1162	GTPase activity
BSY15_2529	COG2154	pterin-4-alpha-carbinolamine dehydratase
BSY15_253	COG2188	Transcriptional regulator
BSY15_2530	COG0501	Belongs to the peptidase M48B family
BSY15_2531	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BSY15_2532	COG0513	Belongs to the DEAD box helicase family
BSY15_2533	COG3447	MASE1 domain protein
BSY15_2533	COG5002	protein histidine kinase activity
BSY15_2533	COG5001	Diguanylate cyclase
BSY15_2534	COG2814	Major facilitator Superfamily
BSY15_2536	COG2084	Dehydrogenase
BSY15_2538	COG0516	GMP reductase activity
BSY15_2540	COG0210	DNA helicase
BSY15_2543	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSY15_2548	COG0625	glutathione transferase activity
BSY15_255	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BSY15_2551	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSY15_2552	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSY15_2556	COG0412	Dienelactone hydrolase
BSY15_256	COG1053	succinate dehydrogenase
BSY15_2560	COG3275	phosphorelay sensor kinase activity
BSY15_2561	COG0165	Argininosuccinate lyase
BSY15_2563	COG0753	catalase activity
BSY15_2565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSY15_2566	COG3447	MASE1 domain protein
BSY15_2566	COG5002	protein histidine kinase activity
BSY15_2566	COG5001	Diguanylate cyclase
BSY15_2567	COG1304	FMN binding
BSY15_2569	COG1595	DNA-templated transcription, initiation
BSY15_257	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BSY15_258	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BSY15_2580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BSY15_2581	COG0840	transmembrane signaling receptor activity
BSY15_2582	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BSY15_2582	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BSY15_2584	COG3022	response to hydroperoxide
BSY15_2585	COG1530	ribonuclease E activity
BSY15_2589	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BSY15_2589	COG0616	signal peptide processing
BSY15_259	COG0372	Belongs to the citrate synthase family
BSY15_2590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BSY15_2591	COG0424	maF-like protein
BSY15_2592	COG1399	metal-binding, possibly nucleic acid-binding protein
BSY15_2593	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BSY15_2594	COG0416	fatty acid biosynthetic process
BSY15_2595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BSY15_2597	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_2598	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BSY15_2599	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BSY15_26	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BSY15_2603	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BSY15_2604	COG0481	GTPase activity
BSY15_2605	COG0681	Belongs to the peptidase S26 family
BSY15_2607	COG0571	ribonuclease III activity
BSY15_2608	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BSY15_2609	COG1381	Involved in DNA repair and RecF pathway recombination
BSY15_261	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BSY15_2610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BSY15_2611	COG0736	holo-[acyl-carrier-protein] synthase activity
BSY15_2612	COG1472	Belongs to the glycosyl hydrolase 3 family
BSY15_2614	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BSY15_2615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BSY15_2616	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BSY15_262	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BSY15_2625	COG0762	integral membrane protein
BSY15_2626	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BSY15_2627	COG0159	tryptophan synthase activity
BSY15_2628	COG0133	tryptophan synthase activity
BSY15_2629	COG0135	phosphoribosylanthranilate isomerase activity
BSY15_2630	COG0101	tRNA pseudouridine synthase activity
BSY15_2632	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BSY15_2635	COG0473	3-isopropylmalate dehydrogenase activity
BSY15_2636	COG0066	3-isopropylmalate dehydratase activity
BSY15_2638	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BSY15_2640	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BSY15_2641	COG0484	heat shock protein binding
BSY15_2642	COG0443	Heat shock 70 kDa protein
BSY15_2643	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BSY15_2644	COG0360	Binds together with S18 to 16S ribosomal RNA
BSY15_2646	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BSY15_2647	COG0359	binds to the 23S rRNA
BSY15_2648	COG0305	Participates in initiation and elongation during chromosome replication
BSY15_2650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BSY15_2651	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BSY15_2653	COG0436	Aminotransferase
BSY15_2658	COG1763	Mo-molybdopterin cofactor biosynthetic process
BSY15_266	COG4191	Histidine kinase
BSY15_2661	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BSY15_2665	COG0314	molybdopterin synthase activity
BSY15_2666	COG0542	response to heat
BSY15_267	COG3437	response regulator, receiver
BSY15_2670	COG2264	protein methyltransferase activity
BSY15_2672	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BSY15_2673	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BSY15_2676	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSY15_2676	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSY15_268	COG2194	sulfuric ester hydrolase activity
BSY15_2684	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BSY15_2685	COG1185	polyribonucleotide nucleotidyltransferase activity
BSY15_2686	COG0604	alcohol dehydrogenase
BSY15_2686	COG3321	synthase
BSY15_2686	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_2687	COG0149	triose-phosphate isomerase activity
BSY15_2690	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BSY15_2691	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BSY15_2692	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BSY15_2693	COG0649	NAD binding
BSY15_2694	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BSY15_2695	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BSY15_2696	COG1034	ATP synthesis coupled electron transport
BSY15_2697	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BSY15_2698	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BSY15_2700	COG0713	ATP synthesis coupled electron transport
BSY15_2703	COG1007	ATP synthesis coupled electron transport
BSY15_2706	COG1132	(ABC) transporter
BSY15_271	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BSY15_2710	COG0559	Belongs to the binding-protein-dependent transport system permease family
BSY15_2718	COG0071	Belongs to the small heat shock protein (HSP20) family
BSY15_2719	COG4181	ATPase activity
BSY15_2720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BSY15_2721	COG2814	Major facilitator Superfamily
BSY15_2722	COG2267	carboxylic ester hydrolase activity
BSY15_2724	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BSY15_2725	COG0584	glycerophosphoryl diester phosphodiesterase
BSY15_2726	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BSY15_2727	COG0586	Pfam SNARE associated Golgi protein
BSY15_2729	COG0840	transmembrane signaling receptor activity
BSY15_2730	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSY15_2731	COG0802	atpase or kinase
BSY15_2732	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BSY15_2736	COG4974	Belongs to the 'phage' integrase family
BSY15_2737	COG3181	Tripartite tricarboxylate transporter family receptor
BSY15_2738	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BSY15_2739	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BSY15_2740	COG2833	Protein of unknown function (DUF455)
BSY15_2742	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BSY15_2745	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BSY15_2746	COG0148	phosphopyruvate hydratase activity
BSY15_2748	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BSY15_2749	COG0504	CTP synthase activity
BSY15_275	COG1960	acyl-CoA dehydrogenase activity
BSY15_2750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BSY15_2752	COG0756	dUTP diphosphatase activity
BSY15_2754	COG1047	Peptidyl-prolyl cis-trans
BSY15_2755	COG2850	peptidyl-arginine hydroxylation
BSY15_2758	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BSY15_2759	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BSY15_2763	COG0187	DNA topoisomerase II activity
BSY15_2764	COG0741	lytic transglycosylase activity
BSY15_2766	COG0840	transmembrane signaling receptor activity
BSY15_2769	COG2308	Evidence 4 Homologs of previously reported genes of
BSY15_2771	COG4628	conserved protein (DUF2132)
BSY15_2774	COG0436	Aminotransferase
BSY15_2777	COG0861	Integral membrane protein TerC family
BSY15_278	COG3264	Mechanosensitive ion channel
BSY15_278	COG1196	nuclear chromosome segregation
BSY15_2781	COG3634	alkyl hydroperoxide reductase activity
BSY15_2782	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BSY15_2783	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BSY15_2786	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSY15_279	COG1024	Enoyl-CoA hydratase
BSY15_2790	COG0583	DNA-binding transcription factor activity
BSY15_2791	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BSY15_2792	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BSY15_2794	COG0840	transmembrane signaling receptor activity
BSY15_2796	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BSY15_2797	COG0358	DNA primase activity
BSY15_2798	COG0318	PFAM AMP-dependent synthetase and ligase
BSY15_280	COG0123	including yeast histone deacetylase and acetoin utilization protein
BSY15_2804	COG3540	Alkaline phosphatase
BSY15_2805	COG3706	GGDEF domain
BSY15_2805	COG0745	RESPONSE REGULATOR receiver
BSY15_2807	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BSY15_2808	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BSY15_281	COG0714	Associated with various cellular activities
BSY15_2810	COG0564	pseudouridine synthase activity
BSY15_2811	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BSY15_2812	COG1187	pseudouridine synthase activity
BSY15_2813	COG0105	UTP biosynthetic process
BSY15_2814	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BSY15_2817	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BSY15_2818	COG0124	histidyl-tRNA synthetase
BSY15_2820	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BSY15_2821	COG1160	GTP binding
BSY15_2822	COG1923	regulation of RNA biosynthetic process
BSY15_2823	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BSY15_2824	COG0330	HflC and HflK could
BSY15_2826	COG0330	HflC and HflK could
BSY15_2827	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BSY15_2828	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BSY15_2835	COG1187	pseudouridine synthase activity
BSY15_284	COG2951	lytic endotransglycosylase activity
BSY15_2843	COG3852	Histidine kinase
BSY15_2846	COG0708	Exodeoxyribonuclease III
BSY15_2849	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BSY15_285	COG0683	leucine binding
BSY15_2851	COG1175	transmembrane transport
BSY15_2852	COG0395	ABC-type sugar transport system, permease component
BSY15_2855	COG0246	Mannitol dehydrogenase
BSY15_2856	COG2207	Transcriptional regulator
BSY15_2857	COG1070	Carbohydrate kinase
BSY15_2860	COG0277	FAD linked oxidase domain protein
BSY15_2862	COG1295	ribonuclease BN
BSY15_2864	COG2267	carboxylic ester hydrolase activity
BSY15_2868	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BSY15_287	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BSY15_2870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BSY15_2871	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BSY15_2872	COG0741	lytic transglycosylase activity
BSY15_2876	COG0557	exoribonuclease II activity
BSY15_2877	COG2267	carboxylic ester hydrolase activity
BSY15_2879	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BSY15_2879	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BSY15_288	COG0683	leucine binding
BSY15_2880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSY15_2882	COG0052	Belongs to the universal ribosomal protein uS2 family
BSY15_2883	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BSY15_2884	COG0528	UMP kinase activity
BSY15_2885	COG0233	cytoplasmic translational termination
BSY15_2886	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BSY15_2889	COG0750	zinc metalloprotease
BSY15_2892	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BSY15_2893	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BSY15_2894	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BSY15_2895	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BSY15_2896	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BSY15_2897	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BSY15_2898	COG0505	Belongs to the CarA family
BSY15_290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSY15_2900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BSY15_2901	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BSY15_2904	COG1534	Rna-binding protein
BSY15_2905	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BSY15_2906	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BSY15_2908	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BSY15_291	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSY15_2915	COG0573	inorganic phosphate transmembrane transporter activity
BSY15_2916	COG0581	inorganic phosphate transmembrane transporter activity
BSY15_2917	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BSY15_2919	COG0745	RESPONSE REGULATOR receiver
BSY15_292	COG1116	anion transmembrane transporter activity
BSY15_2920	COG0534	Mate efflux family protein
BSY15_2923	COG0254	rRNA binding
BSY15_2924	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BSY15_2927	COG1074	ATP-dependent DNA helicase activity
BSY15_2928	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
BSY15_293	COG0517	IMP dehydrogenase activity
BSY15_2930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BSY15_2931	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BSY15_2935	COG1388	LysM domain
BSY15_2935	COG0741	lytic transglycosylase activity
BSY15_2936	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSY15_2937	COG2226	methyltransferase
BSY15_2938	COG0328	RNA-DNA hybrid ribonuclease activity
BSY15_2939	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSY15_2940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BSY15_2943	COG0303	'Molybdopterin
BSY15_2945	COG0746	molybdenum cofactor guanylyltransferase activity
BSY15_2946	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BSY15_2955	COG2205	protein histidine kinase activity
BSY15_2955	COG0784	Response regulator, receiver
BSY15_2955	COG5002	protein histidine kinase activity
BSY15_2957	COG3437	response regulator, receiver
BSY15_296	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BSY15_2960	COG1858	cytochrome C peroxidase
BSY15_2962	COG0745	RESPONSE REGULATOR receiver
BSY15_2963	COG2205	protein histidine kinase activity
BSY15_2965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BSY15_2968	COG0596	Alpha beta hydrolase
BSY15_2968	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BSY15_2968	COG2226	methyltransferase
BSY15_2969	COG0840	transmembrane signaling receptor activity
BSY15_297	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BSY15_2971	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BSY15_2971	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BSY15_2972	COG0347	Belongs to the P(II) protein family
BSY15_2973	COG0640	Transcriptional regulator
BSY15_2978	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BSY15_298	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BSY15_2983	COG0028	Belongs to the TPP enzyme family
BSY15_2984	COG0440	acetolactate synthase activity
BSY15_2985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BSY15_2986	COG1183	phosphatidylcholine synthase activity
BSY15_2987	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BSY15_2989	COG1414	Transcriptional regulator
BSY15_299	COG3265	gluconokinase activity
BSY15_2990	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BSY15_2991	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BSY15_2994	COG2832	Protein of unknown function (DUF454)
BSY15_2995	COG0242	peptide deformylase activity
BSY15_2997	COG0024	Methionine aminopeptidase
BSY15_2998	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BSY15_2998	COG0047	phosphoribosylformylglycinamidine synthase activity
BSY15_2999	COG2264	protein methyltransferase activity
BSY15_3	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BSY15_300	COG1609	Transcriptional regulator
BSY15_3000	COG2354	Protein conserved in bacteria
BSY15_3001	COG3047	cAMP biosynthetic process
BSY15_3003	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BSY15_3004	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BSY15_3006	COG2205	protein histidine kinase activity
BSY15_3007	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BSY15_3008	COG0826	peptidase U32
BSY15_301	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_3012	COG1619	proteins homologs of microcin C7 resistance protein MccF
BSY15_3013	COG3039	Transposase
BSY15_302	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BSY15_3022	COG1024	Enoyl-CoA hydratase
BSY15_3023	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSY15_3026	COG2022	thiamine diphosphate biosynthetic process
BSY15_3029	COG0351	phosphomethylpyrimidine kinase
BSY15_3032	COG0492	ferredoxin-NADP+ reductase activity
BSY15_3033	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BSY15_3034	COG2895	sulfate adenylyltransferase (ATP) activity
BSY15_3034	COG0529	Catalyzes the synthesis of activated sulfate
BSY15_3035	COG0175	sulfate reduction
BSY15_3039	COG0730	response to heat
BSY15_304	COG0318	PFAM AMP-dependent synthetase and ligase
BSY15_3040	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BSY15_3040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSY15_3041	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BSY15_3042	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BSY15_3043	COG0431	NADPH-dependent FMN reductase
BSY15_3044	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSY15_3046	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSY15_3048	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSY15_3049	COG1116	anion transmembrane transporter activity
BSY15_3052	COG2175	clavaminate synthase activity
BSY15_3054	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSY15_3055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSY15_3057	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSY15_3058	COG3119	arylsulfatase activity
BSY15_3059	COG0583	DNA-binding transcription factor activity
BSY15_3062	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BSY15_3068	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSY15_307	COG1846	Transcriptional regulator
BSY15_3071	COG1595	DNA-templated transcription, initiation
BSY15_3073	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BSY15_3079	COG2814	Major facilitator Superfamily
BSY15_308	COG0840	transmembrane signaling receptor activity
BSY15_3080	COG0798	PFAM Bile acid sodium symporter
BSY15_3083	COG0456	acetyltransferase
BSY15_3087	COG0583	DNA-binding transcription factor activity
BSY15_309	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BSY15_3092	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BSY15_3093	COG0583	DNA-binding transcription factor activity
BSY15_3096	COG0840	transmembrane signaling receptor activity
BSY15_3098	COG0840	transmembrane signaling receptor activity
BSY15_3100	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BSY15_3102	COG4208	sulfate ABC transporter
BSY15_3103	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BSY15_3104	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BSY15_3112	COG3842	ATPase activity
BSY15_3113	COG1840	ABC-type Fe3 transport system, periplasmic component
BSY15_3115	COG3842	ATPase activity
BSY15_3116	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BSY15_3117	COG0840	transmembrane signaling receptor activity
BSY15_312	COG0243	molybdopterin cofactor binding
BSY15_3120	COG0583	DNA-binding transcription factor activity
BSY15_3122	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BSY15_3122	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BSY15_3123	COG1643	Atp-dependent helicase
BSY15_3125	COG0318	PFAM AMP-dependent synthetase and ligase
BSY15_3129	COG0589	response to stress
BSY15_313	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BSY15_3130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BSY15_3132	COG0183	Belongs to the thiolase family
BSY15_3133	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_3134	COG0564	pseudouridine synthase activity
BSY15_3138	COG0789	Transcriptional regulator
BSY15_3139	COG0545	Peptidyl-prolyl cis-trans isomerase
BSY15_3143	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BSY15_3143	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BSY15_3144	COG0509	glycine decarboxylation via glycine cleavage system
BSY15_3145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BSY15_3148	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BSY15_3152	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BSY15_3153	COG0287	Prephenate dehydrogenase
BSY15_3154	COG1605	Chorismate mutase
BSY15_3154	COG0077	Prephenate dehydratase
BSY15_3155	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BSY15_3158	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BSY15_316	COG1607	acyl-coa hydrolase
BSY15_3164	COG0745	RESPONSE REGULATOR receiver
BSY15_3165	COG2205	protein histidine kinase activity
BSY15_3167	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSY15_3170	COG2986	histidine ammonia-lyase
BSY15_3171	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BSY15_3173	COG1228	amidohydrolase
BSY15_3177	COG0688	phosphatidylethanolamine metabolic process
BSY15_3179	COG0411	ABC transporter
BSY15_3181	COG0559	Belongs to the binding-protein-dependent transport system permease family
BSY15_3182	COG1280	lysine exporter protein (LysE YggA)
BSY15_3185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BSY15_3188	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BSY15_3190	COG2917	probably involved in intracellular septation
BSY15_3191	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSY15_3192	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BSY15_3193	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BSY15_3194	COG0318	PFAM AMP-dependent synthetase and ligase
BSY15_3196	COG0559	Belongs to the binding-protein-dependent transport system permease family
BSY15_3198	COG0411	ABC transporter
BSY15_320	COG2081	HI0933 family
BSY15_3200	COG1024	Enoyl-CoA hydratase
BSY15_3200	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSY15_3201	COG0183	Belongs to the thiolase family
BSY15_3205	COG1960	acyl-CoA dehydrogenase activity
BSY15_3207	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_3209	COG2130	NADP-dependent
BSY15_3210	COG2153	protein acetylation
BSY15_3211	COG1960	acyl-CoA dehydrogenase activity
BSY15_3214	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BSY15_3216	COG5001	Diguanylate cyclase
BSY15_3216	COG2203	Gaf domain
BSY15_3216	COG4251	negative regulation of phosphorylation
BSY15_3216	COG3706	GGDEF domain
BSY15_3219	COG2183	response to ionizing radiation
BSY15_322	COG5001	Diguanylate cyclase
BSY15_322	COG3300	MHYT domain
BSY15_3227	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BSY15_3228	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BSY15_3229	COG0470	DNA polymerase III
BSY15_323	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BSY15_3231	COG0084	hydrolase, TatD family'
BSY15_3233	COG1132	(ABC) transporter
BSY15_3234	COG0823	Involved in the tonB-independent uptake of proteins
BSY15_3237	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BSY15_3247	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BSY15_3248	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BSY15_325	COG0583	DNA-binding transcription factor activity
BSY15_3258	COG3328	transposase activity
BSY15_326	COG0473	3-isopropylmalate dehydrogenase activity
BSY15_3268	COG5377	YqaJ viral recombinase family
BSY15_3279	COG0789	Transcriptional regulator
BSY15_328	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BSY15_3280	COG4372	Transposase
BSY15_3285	COG1024	Enoyl-CoA hydratase
BSY15_3286	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BSY15_3290	COG1022	Amp-dependent synthetase and ligase
BSY15_3291	COG0559	Belongs to the binding-protein-dependent transport system permease family
BSY15_3295	COG1960	acyl-CoA dehydrogenase activity
BSY15_33	COG3278	Belongs to the heme-copper respiratory oxidase family
BSY15_330	COG0415	Belongs to the DNA photolyase family
BSY15_331	COG3046	protein related to deoxyribodipyrimidine photolyase
BSY15_3310	COG2801	Transposase and inactivated derivatives
BSY15_332	COG0312	modulator of DNA gyrase
BSY15_3320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BSY15_3321	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BSY15_3324	COG0567	Dehydrogenase, E1 component
BSY15_3325	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSY15_3326	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSY15_3327	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BSY15_3329	COG0631	protein serine/threonine phosphatase activity
BSY15_333	COG3028	Belongs to the UPF0307 family
BSY15_3331	COG1199	ATP-dependent helicase activity
BSY15_3333	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BSY15_3334	COG0542	response to heat
BSY15_3335	COG2951	lytic endotransglycosylase activity
BSY15_3336	COG2925	Exonuclease
BSY15_3337	COG0626	cystathionine gamma-synthase activity
BSY15_3338	COG0700	Nucleoside recognition
BSY15_3339	COG0217	transcriptional regulatory protein
BSY15_334	COG0521	Mo-molybdopterin cofactor biosynthetic process
BSY15_3340	COG0484	heat shock protein binding
BSY15_3345	COG3706	GGDEF domain
BSY15_3346	COG0842	Transport permease protein
BSY15_3347	COG0402	S-adenosylhomocysteine deaminase activity
BSY15_3348	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BSY15_3352	COG0433	COG0433 Predicted ATPase
BSY15_3353	COG0217	transcriptional regulatory protein
BSY15_3354	COG0151	Belongs to the GarS family
BSY15_3355	COG0408	coproporphyrinogen oxidase activity
BSY15_3356	COG0799	negative regulation of ribosome biogenesis
BSY15_3357	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BSY15_3358	COG0424	maF-like protein
BSY15_3359	COG1530	ribonuclease E activity
BSY15_336	COG1045	serine acetyltransferase
BSY15_3361	COG0436	Aminotransferase
BSY15_3362	COG0583	DNA-binding transcription factor activity
BSY15_3366	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BSY15_3370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BSY15_3372	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BSY15_3373	COG0252	asparaginase activity
BSY15_3376	COG0563	adenylate kinase activity
BSY15_3377	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BSY15_3378	COG2835	tetraacyldisaccharide 4'-kinase activity
BSY15_3379	COG1663	tetraacyldisaccharide 4'-kinase activity
BSY15_3379	COG2835	tetraacyldisaccharide 4'-kinase activity
BSY15_3380	COG0848	biopolymer transport protein
BSY15_3381	COG0811	peptide transport
BSY15_3382	COG1570	exodeoxyribonuclease VII activity
BSY15_3383	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BSY15_3392	COG1960	acyl-CoA dehydrogenase activity
BSY15_3395	COG0583	DNA-binding transcription factor activity
BSY15_340	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BSY15_3402	COG1132	(ABC) transporter
BSY15_3406	COG1196	nuclear chromosome segregation
BSY15_3408	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BSY15_3416	COG3243	poly(R)-hydroxyalkanoic acid synthase
BSY15_3417	COG0183	Belongs to the thiolase family
BSY15_3418	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_3420	COG2890	protein-(glutamine-N5) methyltransferase activity
BSY15_3421	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSY15_3423	COG2171	N-acyltransferase activity
BSY15_3425	COG0840	transmembrane signaling receptor activity
BSY15_3426	COG2878	Part of a membrane complex involved in electron transport
BSY15_3431	COG0204	Acyl-transferase
BSY15_3432	COG1022	Amp-dependent synthetase and ligase
BSY15_3433	COG1802	Transcriptional regulator
BSY15_3435	COG1703	isobutyryl-CoA mutase activity
BSY15_3436	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BSY15_3438	COG0439	Biotin carboxylase
BSY15_3440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BSY15_3445	COG0640	Transcriptional regulator
BSY15_3452	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_3455	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BSY15_3461	COG4372	Transposase
BSY15_3463	COG0840	transmembrane signaling receptor activity
BSY15_3464	COG3039	Transposase
BSY15_3465	COG3328	transposase activity
BSY15_3476	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BSY15_348	COG1968	undecaprenyl-diphosphatase activity
BSY15_3490	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BSY15_3492	COG1017	nitric oxide dioxygenase activity
BSY15_3492	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BSY15_3493	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BSY15_3494	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSY15_3497	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSY15_3500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSY15_3502	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BSY15_3509	COG1012	belongs to the aldehyde dehydrogenase family
BSY15_3511	COG0583	DNA-binding transcription factor activity
BSY15_3519	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BSY15_352	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSY15_3522	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BSY15_3537	COG0789	Transcriptional regulator
BSY15_3539	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BSY15_3546	COG0625	glutathione transferase activity
BSY15_3548	COG1309	transcriptional regulator
BSY15_3549	COG0625	glutathione transferase activity
BSY15_3551	COG2963	transposase activity
BSY15_3555	COG0346	lactoylglutathione lyase activity
BSY15_3558	COG2032	superoxide dismutase activity
BSY15_3559	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BSY15_3560	COG0789	Transcriptional regulator
BSY15_3562	COG4221	oxidoreductase activity
BSY15_3566	COG1309	transcriptional regulator
BSY15_3567	COG0259	pyridoxamine-phosphate oxidase activity
BSY15_357	COG3275	phosphorelay sensor kinase activity
BSY15_3572	COG5002	protein histidine kinase activity
BSY15_3578	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BSY15_358	COG3279	Response regulator of the LytR AlgR family
BSY15_3580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSY15_3581	COG1309	transcriptional regulator
BSY15_3584	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BSY15_3586	COG1538	Outer membrane efflux protein
BSY15_3589	COG3976	FMN-binding domain protein
BSY15_3589	COG1053	succinate dehydrogenase
BSY15_359	COG4133	protoheme IX ABC transporter activity
BSY15_3600	COG0583	DNA-binding transcription factor activity
BSY15_3602	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BSY15_3607	COG1040	competence protein
BSY15_3608	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BSY15_3610	COG2133	pyrroloquinoline quinone binding
BSY15_3611	COG0791	NLP P60 protein
BSY15_3619	COG0745	RESPONSE REGULATOR receiver
BSY15_3622	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BSY15_3623	COG3145	DNA-N1-methyladenine dioxygenase activity
BSY15_3626	COG4566	intracellular signal transduction
BSY15_3631	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BSY15_3632	COG2366	antibiotic biosynthetic process
BSY15_3633	COG0527	aspartate kinase activity
BSY15_3635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSY15_3636	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSY15_3637	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BSY15_3639	COG4566	intracellular signal transduction
BSY15_3640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BSY15_3643	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BSY15_3644	COG0167	dihydroorotate dehydrogenase activity
BSY15_3648	COG0579	oxidoreductase
BSY15_365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSY15_365	COG2205	protein histidine kinase activity
BSY15_3655	COG0443	Heat shock 70 kDa protein
BSY15_3657	COG0316	Belongs to the HesB IscA family
BSY15_3658	COG0822	iron-sulfur transferase activity
BSY15_3659	COG1104	cysteine desulfurase activity
BSY15_3660	COG1959	2 iron, 2 sulfur cluster binding
BSY15_3664	COG3384	dioxygenase
BSY15_3665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BSY15_3668	COG3181	Tripartite tricarboxylate transporter family receptor
BSY15_3670	COG0583	DNA-binding transcription factor activity
BSY15_3677	COG1739	Uncharacterized protein family UPF0029
BSY15_3678	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSY15_3686	COG0583	DNA-binding transcription factor activity
BSY15_369	COG0745	RESPONSE REGULATOR receiver
BSY15_3690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BSY15_3691	COG4181	ATPase activity
BSY15_3697	COG0745	RESPONSE REGULATOR receiver
BSY15_3697	COG3706	GGDEF domain
BSY15_3698	COG0455	bacterial-type flagellum organization
BSY15_37	COG0318	PFAM AMP-dependent synthetase and ligase
BSY15_3700	COG1741	Belongs to the pirin family
BSY15_3702	COG1741	Belongs to the pirin family
BSY15_3703	COG0583	DNA-binding transcription factor activity
BSY15_3704	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BSY15_3704	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSY15_3705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BSY15_3706	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BSY15_3707	COG3706	GGDEF domain
BSY15_3708	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BSY15_3709	COG1012	belongs to the aldehyde dehydrogenase family
BSY15_373	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BSY15_374	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BSY15_374	COG3608	succinylglutamate desuccinylase aspartoacylase
BSY15_3749	COG3728	DNA packaging
BSY15_3749	COG5484	DNA packaging
BSY15_3755	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BSY15_3781	COG2974	May be involved in recombination
BSY15_3784	COG0756	dUTP diphosphatase activity
BSY15_3827	COG3728	DNA packaging
BSY15_3827	COG5484	DNA packaging
BSY15_3833	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BSY15_385	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BSY15_3858	COG2974	May be involved in recombination
BSY15_3861	COG0756	dUTP diphosphatase activity
BSY15_3865	COG0840	transmembrane signaling receptor activity
BSY15_3867	COG2982	Protein involved in outer membrane biogenesis
BSY15_3868	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BSY15_3871	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BSY15_3872	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BSY15_3875	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_3877	COG0840	transmembrane signaling receptor activity
BSY15_3882	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BSY15_3883	COG4336	lyase activity
BSY15_3884	COG0583	DNA-binding transcription factor activity
BSY15_3886	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BSY15_3888	COG2111	Na H antiporter
BSY15_3888	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BSY15_3889	COG1006	Multisubunit Na H antiporter MnhC subunit
BSY15_3890	COG0651	ATP synthesis coupled electron transport
BSY15_3891	COG1863	multisubunit Na H antiporter MnhE subunit
BSY15_3892	COG2212	antiporter activity
BSY15_3899	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BSY15_3902	COG1322	Protein conserved in bacteria
BSY15_3906	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BSY15_3908	COG0123	including yeast histone deacetylase and acetoin utilization protein
BSY15_3910	COG1840	ABC-type Fe3 transport system, periplasmic component
BSY15_3912	COG3039	Transposase
BSY15_3919	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BSY15_3921	COG1286	toxin biosynthetic process
BSY15_3923	COG0285	dihydrofolate synthase activity
BSY15_3924	COG1393	Belongs to the ArsC family
BSY15_3926	COG3123	guanosine phosphorylase activity
BSY15_3927	COG0137	argininosuccinate synthase activity
BSY15_3930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BSY15_3931	COG1666	GTP binding
BSY15_3932	COG3577	Aspartyl protease
BSY15_3934	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BSY15_3935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BSY15_3936	COG0583	DNA-binding transcription factor activity
BSY15_3937	COG3181	Tripartite tricarboxylate transporter family receptor
BSY15_3939	COG0667	Aldo Keto reductase
BSY15_394	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BSY15_3941	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BSY15_3942	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BSY15_3943	COG0308	aminopeptidase N
BSY15_3944	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BSY15_3950	COG0789	Transcriptional regulator
BSY15_3951	COG0776	regulation of translation
BSY15_3952	COG0072	phenylalanine-tRNA ligase activity
BSY15_3952	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSY15_3953	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BSY15_3954	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BSY15_3955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BSY15_3956	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BSY15_3957	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BSY15_396	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BSY15_3961	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BSY15_3963	COG4774	siderophore transport
BSY15_3964	COG3128	pkhd-type hydroxylase
BSY15_397	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BSY15_3972	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BSY15_3975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BSY15_3978	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BSY15_3978	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BSY15_3978	COG0506	proline dehydrogenase activity
BSY15_398	COG0142	geranyltranstransferase activity
BSY15_3981	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BSY15_3981	COG0519	Catalyzes the synthesis of GMP from XMP
BSY15_3985	COG2867	negative regulation of translational initiation
BSY15_3986	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BSY15_3987	COG1024	Enoyl-CoA hydratase
BSY15_399	COG1722	exodeoxyribonuclease VII activity
BSY15_3990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BSY15_3991	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BSY15_3992	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BSY15_3993	COG0195	Participates in both transcription termination and antitermination
BSY15_3994	COG0779	Required for maturation of 30S ribosomal subunits
BSY15_3995	COG3118	belongs to the thioredoxin family
BSY15_3997	COG2863	cytochrome
BSY15_4000	COG4172	Belongs to the ABC transporter superfamily
BSY15_4001	COG4239	(ABC) transporter, permease
BSY15_4002	COG4174	ABC transporter (Permease)
BSY15_4003	COG4166	transmembrane transport
BSY15_4005	COG1793	dna ligase
BSY15_4006	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BSY15_4007	COG1982	Orn Lys Arg decarboxylase major
BSY15_4013	COG5377	YqaJ viral recombinase family
BSY15_4030	COG0500	methyltransferase
BSY15_4030	COG3615	Tellurite resistance protein tehB
BSY15_4033	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BSY15_4034	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BSY15_4036	COG0583	DNA-binding transcription factor activity
BSY15_4047	COG4974	Belongs to the 'phage' integrase family
BSY15_4059	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BSY15_4062	COG3039	Transposase
BSY15_4070	COG2963	transposase activity
BSY15_4071	COG0024	Methionine aminopeptidase
BSY15_408	COG0628	permease
BSY15_4082	COG0789	Transcriptional regulator
BSY15_4084	COG2200	EAL domain
BSY15_409	COG5001	Diguanylate cyclase
BSY15_4093	COG2132	Multicopper oxidase
BSY15_4094	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BSY15_4098	COG3191	aminopeptidase activity
BSY15_41	COG1802	Transcriptional regulator
BSY15_410	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BSY15_4101	COG0488	(ABC) transporter
BSY15_4102	COG0513	Belongs to the DEAD box helicase family
BSY15_4103	COG0702	epimerase
BSY15_4105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BSY15_4105	COG4651	solute:proton antiporter activity
BSY15_4108	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BSY15_411	COG0181	hydroxymethylbilane synthase activity
BSY15_4110	COG0776	regulation of translation
BSY15_4111	COG0473	3-isopropylmalate dehydrogenase activity
BSY15_4113	COG0322	excinuclease ABC activity
BSY15_4116	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BSY15_4117	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BSY15_4120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BSY15_4121	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BSY15_4122	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BSY15_4125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BSY15_4127	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_4129	COG0745	RESPONSE REGULATOR receiver
BSY15_4130	COG2205	protein histidine kinase activity
BSY15_4131	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BSY15_4132	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BSY15_4132	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BSY15_4133	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BSY15_4137	COG0560	Phosphoserine phosphatase
BSY15_4140	COG2010	Cytochrome c
BSY15_4140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BSY15_4142	COG1959	2 iron, 2 sulfur cluster binding
BSY15_4146	COG0583	DNA-binding transcription factor activity
BSY15_4149	COG3530	Putative quorum-sensing-regulated virulence factor
BSY15_4150	COG0023	Translation Initiation Factor
BSY15_4152	COG0513	Belongs to the DEAD box helicase family
BSY15_4154	COG3447	MASE1 domain protein
BSY15_4154	COG5001	Diguanylate cyclase
BSY15_4154	COG5002	protein histidine kinase activity
BSY15_4155	COG0840	transmembrane signaling receptor activity
BSY15_4156	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BSY15_4158	COG0446	pyridine nucleotide-disulphide oxidoreductase
BSY15_4158	COG1902	pentaerythritol trinitrate reductase activity
BSY15_4160	COG2900	Belongs to the SlyX family
BSY15_4161	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSY15_4163	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BSY15_417	COG2353	YceI-like domain
BSY15_419	COG0525	valine-tRNA ligase activity
BSY15_42	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BSY15_420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BSY15_421	COG0425	Belongs to the sulfur carrier protein TusA family
BSY15_43	COG0583	DNA-binding transcription factor activity
BSY15_435	COG0582	viral genome integration into host DNA
BSY15_438	COG0583	DNA-binding transcription factor activity
BSY15_439	COG1960	acyl-CoA dehydrogenase activity
BSY15_44	COG0129	dihydroxy-acid dehydratase activity
BSY15_443	COG0784	Response regulator, receiver
BSY15_443	COG0835	chemotaxis
BSY15_449	COG4566	intracellular signal transduction
BSY15_452	COG0617	tRNA 3'-terminal CCA addition
BSY15_454	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BSY15_456	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BSY15_46	COG4654	Cytochrome c, class I
BSY15_461	COG1917	Cupin 2, conserved barrel domain protein
BSY15_461	COG4977	sequence-specific DNA binding
BSY15_462	COG0840	transmembrane signaling receptor activity
BSY15_466	COG2912	Transglutaminase-like superfamily
BSY15_467	COG0728	peptidoglycan biosynthetic process
BSY15_468	COG0268	Binds directly to 16S ribosomal RNA
BSY15_470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BSY15_471	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BSY15_476	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BSY15_478	COG3483	tryptophan 2,3-dioxygenase activity
BSY15_481	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BSY15_484	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BSY15_487	COG2916	Histone family protein nucleoid-structuring protein H-NS
BSY15_488	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BSY15_489	COG1477	protein flavinylation
BSY15_492	COG4263	nitrous-oxide reductase activity
BSY15_493	COG3901	Regulator of nitric oxide reductase transcription
BSY15_493	COG0348	domain, Protein
BSY15_496	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BSY15_499	COG0513	Belongs to the DEAD box helicase family
BSY15_5	COG0318	PFAM AMP-dependent synthetase and ligase
BSY15_50	COG0114	fumarate hydratase activity
BSY15_500	COG2321	neutral zinc metallopeptidase
BSY15_501	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BSY15_502	COG2423	ornithine cyclodeaminase activity
BSY15_503	COG0717	Belongs to the dCTP deaminase family
BSY15_504	COG0402	S-adenosylhomocysteine deaminase activity
BSY15_506	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BSY15_507	COG0537	adenosine 5'-monophosphoramidase activity
BSY15_510	COG1129	ABC transporter
BSY15_513	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BSY15_514	COG1136	(ABC) transporter
BSY15_515	COG4591	ABC-type transport system involved in lipoprotein release permease component
BSY15_517	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BSY15_518	COG0840	transmembrane signaling receptor activity
BSY15_519	COG0613	PHP domain protein
BSY15_520	COG0009	L-threonylcarbamoyladenylate synthase
BSY15_523	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BSY15_524	COG3132	Protein of unknown function, DUF480
BSY15_525	COG1960	acyl-CoA dehydrogenase activity
BSY15_526	COG1960	acyl-CoA dehydrogenase activity
BSY15_529	COG0196	riboflavin kinase activity
BSY15_53	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BSY15_530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BSY15_531	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BSY15_532	COG1283	sodium-dependent phosphate transmembrane transporter activity
BSY15_536	COG0697	spore germination
BSY15_539	COG1028	Short-chain dehydrogenase reductase Sdr
BSY15_54	COG1451	nucleotide metabolic process
BSY15_544	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BSY15_547	COG0084	hydrolase, TatD family'
BSY15_548	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BSY15_549	COG0714	Associated with various cellular activities
BSY15_552	COG5002	protein histidine kinase activity
BSY15_552	COG5001	Diguanylate cyclase
BSY15_552	COG3447	MASE1 domain protein
BSY15_563	COG2186	Transcriptional regulator
BSY15_567	COG2233	PERMEase
BSY15_568	COG0280	phosphate acetyltransferase
BSY15_568	COG0281	malic enzyme
BSY15_569	COG1639	'signal transduction protein
BSY15_572	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSY15_573	COG4585	Histidine kinase
BSY15_574	COG2197	response regulator
BSY15_577	COG1752	Esterase of the alpha-beta hydrolase superfamily
BSY15_578	COG0829	nickel cation binding
BSY15_580	COG0436	Aminotransferase
BSY15_583	COG1597	lipid kinase activity
BSY15_585	COG0410	ABC transporter
BSY15_589	COG0559	Belongs to the binding-protein-dependent transport system permease family
BSY15_596	COG0831	urea catabolic process
BSY15_598	COG0832	Belongs to the urease beta subunit family
BSY15_599	COG0804	urea catabolic process
BSY15_6	COG1492	cobalamin metabolic process
BSY15_60	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BSY15_601	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BSY15_602	COG0830	nickel cation binding
BSY15_603	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BSY15_606	COG5001	Diguanylate cyclase
BSY15_606	COG3300	MHYT domain
BSY15_608	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BSY15_609	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BSY15_61	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BSY15_613	COG1561	YicC-like family, N-terminal region
BSY15_614	COG0194	GDP metabolic process
BSY15_615	COG1758	RNA polymerase activity
BSY15_616	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BSY15_62	COG0740	serine-type endopeptidase activity
BSY15_620	COG1420	regulation of RNA biosynthetic process
BSY15_621	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BSY15_622	COG0497	DNA recombination
BSY15_623	COG1660	Displays ATPase and GTPase activities
BSY15_624	COG1194	a g-specific adenine glycosylase
BSY15_626	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BSY15_629	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BSY15_63	COG0544	peptidyl-prolyl cis-trans isomerase activity
BSY15_631	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BSY15_632	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BSY15_633	COG0193	aminoacyl-tRNA hydrolase activity
BSY15_634	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BSY15_636	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BSY15_637	COG0444	Belongs to the ABC transporter superfamily
BSY15_638	COG4608	Belongs to the ABC transporter superfamily
BSY15_639	COG0747	negative chemotaxis
BSY15_640	COG0154	amidase activity
BSY15_649	COG0302	gtp cyclohydrolase
BSY15_65	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BSY15_650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BSY15_655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BSY15_658	COG3344	reverse transcriptase
BSY15_659	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSY15_660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BSY15_663	COG2226	methyltransferase
BSY15_667	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BSY15_668	COG1653	transport
BSY15_669	COG1175	transmembrane transport
BSY15_67	COG1562	ergosterol biosynthetic process
BSY15_670	COG0395	ABC-type sugar transport system, permease component
BSY15_672	COG0584	glycerophosphoryl diester phosphodiesterase
BSY15_673	COG3264	Mechanosensitive ion channel
BSY15_673	COG1511	domain protein
BSY15_676	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BSY15_677	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BSY15_678	COG2890	protein-(glutamine-N5) methyltransferase activity
BSY15_679	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BSY15_68	COG1760	l-serine dehydratase
BSY15_680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BSY15_681	COG1253	flavin adenine dinucleotide binding
BSY15_682	COG0741	lytic transglycosylase activity
BSY15_683	COG0442	prolyl-tRNA aminoacylation
BSY15_684	COG0494	nUDIX hydrolase
BSY15_685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BSY15_686	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BSY15_687	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BSY15_688	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BSY15_689	COG0142	geranyltranstransferase activity
BSY15_69	COG1562	ergosterol biosynthetic process
BSY15_694	COG0237	dephospho-CoA kinase activity
BSY15_695	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BSY15_696	COG0494	nUDIX hydrolase
BSY15_698	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BSY15_699	COG0653	protein targeting
BSY15_70	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BSY15_700	COG0739	heme binding
BSY15_703	COG0625	glutathione transferase activity
BSY15_704	COG2857	Cytochrome c1
BSY15_705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BSY15_707	COG1970	mechanosensitive ion channel activity
BSY15_708	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BSY15_709	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BSY15_712	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BSY15_713	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BSY15_714	COG0805	protein transport
BSY15_715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BSY15_716	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BSY15_720	COG0140	phosphoribosyl-ATP diphosphatase activity
BSY15_721	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BSY15_722	COG0107	imidazoleglycerol-phosphate synthase activity
BSY15_723	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BSY15_732	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BSY15_733	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BSY15_734	COG0131	Imidazoleglycerol-phosphate dehydratase
BSY15_735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BSY15_738	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSY15_741	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BSY15_742	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BSY15_743	COG5007	Belongs to the BolA IbaG family
BSY15_744	COG0842	Transport permease protein
BSY15_745	COG1131	(ABC) transporter
BSY15_748	COG2853	Lipoprotein
BSY15_749	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BSY15_750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BSY15_751	COG1127	ABC transporter
BSY15_753	COG0069	glutamate synthase activity
BSY15_753	COG0070	glutamate synthase
BSY15_753	COG0067	glutamate synthase
BSY15_757	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BSY15_758	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BSY15_766	COG1965	Belongs to the frataxin family
BSY15_768	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BSY15_77	COG1011	Hydrolase
BSY15_770	COG1333	cytochrome c biogenesis protein
BSY15_772	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BSY15_774	COG1560	Kdo2-lipid A biosynthetic process
BSY15_776	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BSY15_779	COG0745	RESPONSE REGULATOR receiver
BSY15_779	COG3706	GGDEF domain
BSY15_78	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BSY15_781	COG1051	belongs to the nudix hydrolase family
BSY15_781	COG1056	cytidyltransferase-related domain
BSY15_782	COG3706	GGDEF domain
BSY15_783	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BSY15_784	COG0459	protein refolding
BSY15_785	COG0800	Aldolase
BSY15_79	COG1067	ATP-dependent peptidase activity
BSY15_790	COG0166	Belongs to the GPI family
BSY15_791	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BSY15_794	COG0346	lactoylglutathione lyase activity
BSY15_795	COG0837	glucose binding
BSY15_796	COG3842	ATPase activity
BSY15_797	COG0395	ABC-type sugar transport system, permease component
BSY15_801	COG0745	RESPONSE REGULATOR receiver
BSY15_805	COG0587	DNA-directed DNA polymerase activity
BSY15_807	COG3039	Transposase
BSY15_81	COG3328	transposase activity
BSY15_812	COG2801	Transposase and inactivated derivatives
BSY15_816	COG3039	Transposase
BSY15_817	COG2963	transposase activity
BSY15_818	COG3039	Transposase
BSY15_819	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BSY15_82	COG3706	GGDEF domain
BSY15_82	COG0745	RESPONSE REGULATOR receiver
BSY15_821	COG3706	GGDEF domain
BSY15_822	COG2205	protein histidine kinase activity
BSY15_823	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BSY15_827	COG0583	DNA-binding transcription factor activity
BSY15_829	COG0739	heme binding
BSY15_83	COG0596	Alpha beta hydrolase
BSY15_830	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BSY15_831	COG0316	Belongs to the HesB IscA family
BSY15_834	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BSY15_835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BSY15_837	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BSY15_838	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BSY15_84	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BSY15_841	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BSY15_843	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BSY15_849	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BSY15_850	COG0683	leucine binding
BSY15_851	COG0683	leucine binding
BSY15_853	COG0477	Major facilitator Superfamily
BSY15_858	COG0583	DNA-binding transcription factor activity
BSY15_859	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSY15_860	COG3246	L-lysine catabolic process to acetate
BSY15_861	COG3181	Tripartite tricarboxylate transporter family receptor
BSY15_863	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BSY15_866	COG1024	Enoyl-CoA hydratase
BSY15_867	COG2318	DinB family
BSY15_869	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BSY15_870	COG0318	PFAM AMP-dependent synthetase and ligase
BSY15_873	COG2963	transposase activity
BSY15_874	COG2801	Transposase and inactivated derivatives
BSY15_877	COG0625	glutathione transferase activity
BSY15_879	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BSY15_880	COG3012	SEC-C Motif Domain Protein
BSY15_886	COG1063	alcohol dehydrogenase
BSY15_890	COG2205	protein histidine kinase activity
BSY15_891	COG5002	protein histidine kinase activity
BSY15_892	COG0840	transmembrane signaling receptor activity
BSY15_894	COG1960	acyl-CoA dehydrogenase activity
BSY15_898	COG0183	Belongs to the thiolase family
BSY15_899	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BSY15_900	COG0288	reversible hydration of carbon dioxide
BSY15_901	COG1960	acyl-CoA dehydrogenase activity
BSY15_903	COG0789	Transcriptional regulator
BSY15_907	COG2801	Transposase and inactivated derivatives
BSY15_909	COG2963	transposase activity
BSY15_915	COG3039	Transposase
BSY15_916	COG1706	bacterial-type flagellum-dependent cell motility
BSY15_918	COG1256	bacterial-type flagellum assembly
BSY15_921	COG0583	DNA-binding transcription factor activity
BSY15_922	COG2910	NAD(P)H-binding
BSY15_923	COG0436	Aminotransferase
BSY15_928	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSY15_929	COG0625	glutathione transferase activity
BSY15_931	COG0384	phenazine biosynthesis protein PhzF
BSY15_938	COG1960	acyl-CoA dehydrogenase activity
BSY15_940	COG3181	Tripartite tricarboxylate transporter family receptor
BSY15_945	COG0724	RNA recognition motif
BSY15_950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BSY15_953	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BSY15_954	COG1832	CoA-binding protein
BSY15_958	COG0861	Integral membrane protein TerC family
BSY15_959	COG0583	DNA-binding transcription factor activity
BSY15_964	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BSY15_966	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BSY15_969	COG1473	amidohydrolase
BSY15_972	COG0679	Auxin Efflux Carrier
BSY15_974	COG0210	DNA helicase
BSY15_984	COG3181	Tripartite tricarboxylate transporter family receptor
BSY15_986	COG0343	queuine tRNA-ribosyltransferase activity
BSY15_995	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BSY15_996	COG0204	Acyl-transferase
BSY15_996	COG0318	PFAM AMP-dependent synthetase and ligase