locus-tag class description EI070_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EI070_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EI070_00030 ENOG4105DQR SNARE associated Golgi EI070_00035 ENOG4105C5H ABC transporter EI070_00040 ENOG4108821 RND type efflux pump EI070_00045 ENOG4108821 RND type efflux pump EI070_00050 ENOG4108821 RND type efflux pump EI070_00060 ENOG4105D74 hydrolase EI070_00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) EI070_00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EI070_00115 ENOG4105C8J )-transporter EI070_00125 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EI070_00155 ENOG4105C2W permease EI070_00165 ENOG4108IG5 Transcriptional regulator EI070_00170 ENOG4105DJY efflux transporter, rnd family, mfp subunit EI070_00205 ENOG4105F27 Major Facilitator EI070_00210 ENOG4105CV8 reductase EI070_00215 ENOG4105HEI LysR family (Transcriptional regulator EI070_00235 ENOG4105DQ4 alcohol dehydrogenase EI070_00240 ENOG4108R3E Dna-3-methyladenine glycosylase i EI070_00255 ENOG4105CEN a g-specific adenine glycosylase EI070_00275 ENOG4108ZZ3 UPF0260 protein EI070_00285 ENOG4105D1H recombination factor protein RarA EI070_00290 ENOG4105S64 Formate nitrite transporter EI070_00310 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EI070_00315 ENOG4108RWI nicotinamidase EI070_00320 ENOG4105C09 Bile acid EI070_00325 ENOG4107QI1 Mate efflux family protein EI070_00330 ENOG4105EWC Purine nucleoside phosphorylase EI070_00350 ENOG4108RXX maleylacetoacetate isomerase EI070_00360 ENOG4105C85 amino acid EI070_00370 ENOG4105CKI cobalamin synthesis protein EI070_00380 ENOG4105CZE histidine utilization repressor EI070_00385 ENOG41090B9 response to stress EI070_00400 ENOG4105C85 amino acid EI070_00410 ENOG41088SP formiminoglutamate hydrolase EI070_00425 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EI070_00430 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EI070_00440 ENOG4108ZAI phosphatidylglycerophosphatase a EI070_00445 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EI070_00460 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EI070_00500 ENOG4105KHC sulfurtransferase EI070_00530 ENOG4105BZU Histidine kinase EI070_00535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EI070_00550 ENOG4107QJQ Mate efflux family protein EI070_00555 ENOG4105CHM Aminotransferase EI070_00560 ENOG4106BRA Membrane EI070_00575 ENOG4105D9M gamma-glutamylcysteine synthetase EI070_00585 ENOG4105CS6 Rhs element vgr protein EI070_00590 ENOG4105K4H Nlp p60 protein EI070_00610 ENOG4105IPS esterase EI070_00615 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EI070_00620 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EI070_00625 ENOG4108Z2U ureidoglycolate hydrolase EI070_00635 ENOG41061H0 Monooxygenase EI070_00650 ENOG41084YZ Hydrolase EI070_00680 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) EI070_00685 ENOG4105BZU Histidine kinase EI070_00700 ENOG4105KUZ arsenate reductase EI070_00705 ENOG4105CGK Exodeoxyribonuclease III EI070_00725 ENOG4105D7Z glutathione synthase EI070_00745 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) EI070_00750 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EI070_00755 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EI070_00770 ENOG41063SB peptidase EI070_00775 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EI070_00780 ENOG4107QSN dihydrolipoamide acetyltransferase EI070_00820 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EI070_00835 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EI070_00855 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EI070_00860 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase EI070_00870 ENOG4105D64 Mechanosensitive ion channel EI070_00880 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EI070_00885 ENOG4108W2Y isochorismatase EI070_00895 ENOG4105D5G Transposase EI070_00900 ENOG4105FBW Monooxygenase EI070_00905 ENOG4108UZX fmn reductase EI070_00920 ENOG4105BZU Histidine kinase EI070_00925 ENOG41062QD Membrane EI070_00930 ENOG4107QN1 sodium solute EI070_00940 ENOG4105C94 Transporter EI070_00950 ENOG4105BZU Histidine kinase EI070_00960 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EI070_00965 ENOG4108WUH Transcriptional regulator, TetR family EI070_00970 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EI070_00980 ENOG4105RA2 Membrane EI070_00985 ENOG4105DWF phosphomethylpyrimidine kinase EI070_00995 ENOG4107RDB Major Facilitator EI070_01000 ENOG4108UUM single-stranded DNA-binding protein EI070_01010 ENOG4108UMN azlc family EI070_01020 ENOG4105C85 amino acid EI070_01030 ENOG4108JPW Aminotransferase EI070_01035 ENOG4105C26 Dehydrogenase EI070_01045 ENOG4105CHJ isochorismatase hydrolase EI070_01050 ENOG4105EUB pirin domain protein EI070_01075 ENOG4105D94 Major Facilitator Superfamily EI070_01080 ENOG4106NZI LysR family Transcriptional regulator EI070_01100 ENOG4105CPC Aldo Keto reductase EI070_01105 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) EI070_01135 ENOG4105KVH Transcriptional regulator EI070_01145 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EI070_01210 ENOG4105CUV Homoserine Kinase EI070_01225 ENOG41061CK Antibiotic biosynthesis monooxygenase EI070_01255 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EI070_01285 ENOG4105CYC Transferase EI070_01295 ENOG4105E0F Histidine kinase EI070_01300 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EI070_01305 ENOG4105BZM domain protein EI070_01310 ENOG4105CHH sulfate transporter EI070_01315 ENOG4105PDP Short chain dehydrogenase EI070_01325 ENOG4105C5H ABC transporter EI070_01410 ENOG4108IQI permease EI070_01435 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EI070_01450 ENOG4105CJN penicillin-binding protein EI070_01455 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EI070_01460 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) EI070_01475 ENOG4105DHI Methyltransferase EI070_01480 ENOG4108JQC penicillin-binding protein 1A EI070_01505 ENOG4105E4G Type IV pilus EI070_01525 ENOG4105CBC glutamate synthase EI070_01530 ENOG4105BZ8 glutamate synthase EI070_01540 ENOG4108V0P LemA family EI070_01545 ENOG4105HA9 of methanol dehydrogenase type EI070_01565 ENOG4108YSG O-Antigen polymerase EI070_01570 ENOG4108UQY Iron-storage protein EI070_01580 ENOG4105KME endoribonuclease L-psp EI070_01585 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EI070_01600 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EI070_01650 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EI070_01665 ENOG4107IFA Lipase (EC 3.1.1.3) EI070_01670 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) EI070_01675 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EI070_01700 ENOG4108JQ1 Dehydrogenase EI070_01705 ENOG4105CQB FAD linked oxidase domain protein EI070_01715 ENOG4105VRH Antibiotic biosynthesis monooxygenase EI070_01720 ENOG4105NF4 modulator of drug activity EI070_01730 ENOG4107QF7 multi-drug EI070_01735 ENOG4105EM2 membrane EI070_01740 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EI070_01745 ENOG4105IPI Membrane EI070_01750 ENOG4107SKI cobyrinic Acid a,c-diamide synthase EI070_01780 ENOG4108IQI permease EI070_01785 ENOG4105D82 Glutamate dehydrogenase EI070_01790 ENOG4105C8Y Acetylornithine aminotransferase EI070_01800 ENOG4105C26 Dehydrogenase EI070_01825 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EI070_01885 ENOG4105W87 Cbs domain EI070_01890 ENOG41067S9 phage shock protein C, PspC EI070_01900 ENOG4105CSU acyl-Coa dehydrogenase EI070_01915 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) EI070_01930 ENOG4105ECY inositol monophosphatase EI070_01935 ENOG4105C1J atp-dependent rna helicase EI070_01945 ENOG4105DHJ ABC, transporter EI070_01950 ENOG4105CY3 ABC transporter, permease EI070_01960 ENOG4105E3I toluene tolerance EI070_01970 ENOG4105D7N magnesium and cobalt transport protein CorA EI070_01975 ENOG4108URH decarboxylase EI070_01985 ENOG4105MJ2 Competence protein EI070_01990 ENOG4105CB5 ATP-dependent DNA helicase recG EI070_02010 ENOG4105C29 acyl-CoA thioesterase EI070_02015 ENOG4105CK2 sodium dicarboxylate symporter EI070_02030 ENOG4105KPV Transcriptional regulator EI070_02040 ENOG4105D7A ATP-binding protein EI070_02045 ENOG4105C28 cystathionine EI070_02050 ENOG41089BK Glutamine amido-transferase EI070_02160 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EI070_02165 ENOG41067V7 50S ribosomal protein L36 EI070_02175 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EI070_02200 ENOG4105C1G acyl-Coa dehydrogenase EI070_02235 ENOG4105VKU nucleicacid-binding protein EI070_02240 ENOG4105DGW oligopeptidase A EI070_02245 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EI070_02290 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase EI070_02295 ENOG4108K2B transcriptional regulator EI070_02305 ENOG4107S2Z UPF0761 membrane protein EI070_02310 ENOG4105CS1 NAD(P)H quinone oxidoreductase EI070_02340 ENOG4105C9A Phoh family EI070_02350 ENOG4105E4C Lytic transglycosylase catalytic EI070_02380 ENOG4105D6S protein involved in catabolism of external DNA EI070_02385 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EI070_02430 ENOG4105C1G acyl-Coa dehydrogenase EI070_02435 ENOG4108RZE Tetr family transcriptional regulator EI070_02450 ENOG4107QX3 carboxylase EI070_02455 ENOG4105C1G acyl-Coa dehydrogenase EI070_02475 ENOG4105KB2 stringent starvation protein b EI070_02480 ENOG4107MKT Stringent starvation protein a EI070_02485 ENOG4108UJD 30S ribosomal protein S9 EI070_02495 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EI070_02500 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EI070_02505 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EI070_02525 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EI070_02535 ENOG4107RZC phospholipase d EI070_02545 ENOG4105UYK outer membrane protein a EI070_02550 ENOG4108KHX Diguanylate cyclase EI070_02585 ENOG4107QN2 dihydrolipoyl dehydrogenase EI070_02595 ENOG4107QPB Beta-lactamase domain protein EI070_02600 ENOG4107U2T alpha beta EI070_02610 ENOG4105NAU thioesterase Superfamily protein EI070_02640 ENOG4105K9H YciI-like protein EI070_02650 ENOG4105DB7 PHP domain protein EI070_02655 ENOG4105FFC UPF0187 protein EI070_02665 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EI070_02670 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EI070_02675 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EI070_02680 ENOG4105VIE preprotein translocase, subunit YajC EI070_02730 ENOG4105BZU Histidine kinase EI070_02735 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) EI070_02740 ENOG4105CM2 brancheD-chain amino acid aminotransferase EI070_02755 ENOG4107BJW polysaccharide deacetylase EI070_02765 ENOG4108PQP glycosyl transferase group 1 EI070_02805 ENOG4105UGU tonB-dependent Receptor EI070_02825 ENOG4108VY7 phosphate-starvation-inducible protein PsiE EI070_02830 ENOG4108K3A Glutathione S-transferase EI070_02835 ENOG4108R4R Iron-regulated virulence regulatory protein EI070_02840 ENOG4105CSU acyl-Coa dehydrogenase EI070_02845 ENOG4105CSU acyl-Coa dehydrogenase EI070_02855 ENOG4105EB3 Histidine kinase EI070_02860 ENOG4105E3W Two component transcriptional regulator (Winged helix family EI070_02865 ENOG4105CNG UPF0061 protein EI070_02885 ENOG4108WBT adenosyltransferase EI070_02900 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EI070_02945 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EI070_02965 ENOG4105D3R alkyl hydroperoxide reductase EI070_02980 ENOG4105CSH Transporter EI070_02985 ENOG4108UT2 hemolysin iii EI070_03015 ENOG4105CHU acetyl-coa acetyltransferase EI070_03020 ENOG4108R6W Transcriptional regulator, ARAC family EI070_03030 ENOG4105TW1 Carbohydrate-selective porin OprB EI070_03035 ENOG4105DZG Dehydrogenase EI070_03040 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) EI070_03060 ENOG4105CHU acetyl-coa acetyltransferase EI070_03070 ENOG4108WHA ompa motb domain protein EI070_03080 ENOG4105E0Y RtcB Protein EI070_03085 ENOG4108IQI permease EI070_03095 ENOG4105C2W permease EI070_03115 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EI070_03125 ENOG4108VX5 3-methyladenine DNA glycosylase EI070_03130 ENOG4105CHB tonB-dependent Receptor EI070_03145 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EI070_03150 ENOG4108N2Y auxin Efflux EI070_03160 ENOG4105T95 Thiol disulfide interChange protein EI070_03165 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) EI070_03175 ENOG4105K78 MarR family Transcriptional regulator EI070_03180 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EI070_03185 ENOG4105KWI UPF0339 protein EI070_03210 ENOG4108UNF response regulator EI070_03215 ENOG4105M3Z response regulator EI070_03220 ENOG4108ZGA chew protein EI070_03225 ENOG4105C8Q Methyl-accepting chemotaxis EI070_03230 ENOG4105CBS Chea signal transduction histidine kinase EI070_03245 ENOG4106HKS Entericidin EcnA/B family EI070_03255 ENOG4105WD1 Membrane EI070_03260 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EI070_03300 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EI070_03310 ENOG4105EM2 membrane EI070_03315 ENOG4105C2C drug resistance transporter, Bcr CflA EI070_03335 ENOG4105BZG amino acid carrier protein EI070_03340 ENOG4105D78 K07001 NTE family protein EI070_03345 ENOG4105C7B Threonine dehydratase EI070_03380 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EI070_03390 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EI070_03395 ENOG4105DFF Rod shape-determining protein mreb EI070_03400 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EI070_03405 ENOG4105VQ7 Rod shape-determining protein MreD EI070_03410 ENOG4108Z03 MAF-like protein EI070_03415 ENOG4105C03 ribonuclease EI070_03425 ENOG4105D8T Acyltransferase EI070_03435 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein EI070_03445 ENOG4108X0B nad(p)h dehydrogenase (quinone) EI070_03470 ENOG4105CF7 AraC family transcriptional regulator EI070_03490 ENOG4105C85 amino acid EI070_03495 ENOG4105C7F AcnD-accessory protein PrpF EI070_03500 ENOG4105CTB Polyprenyl synthetase EI070_03505 ENOG4105MSB protein, conserved in bacteria EI070_03520 ENOG4105D78 K07001 NTE family protein EI070_03540 ENOG4105DIJ Phosphoethanolamine transferase EI070_03545 ENOG4105XJC Two component transcriptional regulator (Winged helix family EI070_03550 ENOG4105DHQ Histidine kinase EI070_03570 ENOG4108M0I Transcriptional regulator EI070_03590 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EI070_03610 ENOG4105K8R UPF0145 protein EI070_03615 ENOG4105K8R UPF0145 protein EI070_03620 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EI070_03625 ENOG4105BZS acriflavin resistance protein EI070_03630 ENOG4105C1P efflux transporter, rnd family, mfp subunit EI070_03635 ENOG410841Q phosphoesterase PA-phosphatase related protein EI070_03665 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) EI070_03680 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EI070_03685 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EI070_03690 ENOG4105KVH Transcriptional regulator EI070_03700 ENOG4105CUB amino acid EI070_03715 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EI070_03720 ENOG41084BA UPF0250 protein EI070_03725 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EI070_03760 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit EI070_03765 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein EI070_03775 ENOG4105E33 succinate dehydrogenase EI070_03790 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EI070_03795 ENOG4105C7S Dehydrogenase EI070_03800 ENOG4107QN2 dihydrolipoyl dehydrogenase EI070_03810 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EI070_03820 ENOG4105CKW Inner membrane protein yedI EI070_03825 ENOG4105CGZ zinc metallopeptidase EI070_03830 ENOG4105EEQ Na H antiporter EI070_03860 ENOG4105PNM synthesis protein EI070_03875 ENOG41080TK Universal stress protein EI070_03890 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EI070_03895 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EI070_03910 ENOG4105HBR Rna-binding protein EI070_03920 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EI070_03925 ENOG4105EEI dihydropteroate synthase EI070_03975 ENOG4105CSH Transporter EI070_03980 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EI070_03985 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EI070_04000 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EI070_04020 ENOG41080IJ Diacylglycerol kinase EI070_04030 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase EI070_04035 ENOG4105BZS acriflavin resistance protein EI070_04050 ENOG4105E4C Lytic transglycosylase catalytic EI070_04075 ENOG4108RRZ Transcription elongation factor GreB EI070_04090 ENOG4105CEY Amp-dependent synthetase and ligase EI070_04135 ENOG4105BZW Glycerate kinase EI070_04140 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit EI070_04145 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EI070_04155 ENOG4108HWY Beta-lactamase EI070_04175 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) EI070_04185 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EI070_04190 ENOG4105C85 amino acid EI070_04200 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EI070_04210 ENOG4105N14 lysine exporter protein LysE YggA EI070_04215 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EI070_04220 ENOG4105BZJ Electron transfer flavoprotein EI070_04225 ENOG4105C10 Electron transfer flavoprotein EI070_04230 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EI070_04265 ENOG4107KET secretion protein, HlyD family EI070_04295 ENOG4105D60 lipoprotein releasing system transmembrane protein EI070_04300 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EI070_04305 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EI070_04315 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EI070_04320 ENOG4107R6F Alpha Beta Hydrolase Fold protein EI070_04325 ENOG4108V3E phosphoribosylglycinamide formyltransferase EI070_04335 ENOG4105C02 permease EI070_04385 ENOG4105KCK Peptidoglycan-associated lipoprotein EI070_04390 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) EI070_04400 ENOG4105M8F Biopolymer transport protein exbD tolR EI070_04405 ENOG4105E02 MotA TolQ exbB proton channel EI070_04410 ENOG4107YD3 Thioesterase EI070_04415 ENOG4105CH2 amidohydrolase EI070_04435 ENOG4108ETH Formylglycinamide ribotide synthetase EI070_04440 ENOG4105C2C drug resistance transporter, Bcr CflA EI070_04445 ENOG4105EGD dinuclear metal center protein, YbgI family EI070_04450 ENOG4108UKI Enoyl-CoA hydratase EI070_04465 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EI070_04480 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EI070_04485 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EI070_04500 ENOG4107R11 Transcriptional regulator EI070_04505 ENOG4108IJ6 ABC transporter EI070_04515 ENOG4108I5D sulfate abc transporter EI070_04525 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EI070_04530 ENOG4105YAZ 4-amino-4-deoxychorismate lyase EI070_04535 ENOG4105HHA aminodeoxychorismate lyase EI070_04560 ENOG4108HWY Beta-lactamase EI070_04570 ENOG4108IYU L-aspartate oxidase EI070_04575 ENOG4105C0H protease EI070_04590 ENOG4105C3F Signal peptidase i EI070_04605 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EI070_04615 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) EI070_04620 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) EI070_04625 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase EI070_04630 ENOG4105EMU Dehydrogenase EI070_04670 ENOG4105BZU Histidine kinase EI070_04680 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EI070_04690 ENOG4105DTR rard protein EI070_04725 ENOG4107QS8 (LipO)protein EI070_04730 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EI070_04735 ENOG4105EA8 2-Nitropropane dioxygenase EI070_04765 ENOG4107R8N Glycosyl transferase, family 2 EI070_04780 ENOG4105CVP deoxyribo-dipyrimidine photolyase EI070_04785 ENOG4108YZY peptidylprolyl cis-trans isomerase EI070_04790 ENOG4105CEP NADH dehydrogenase EI070_04795 ENOG4105DZ1 carboxypeptidase EI070_04805 ENOG4105E9K Isocitrate dehydrogenase EI070_04810 ENOG4108R99 pseudouridine synthase EI070_04835 ENOG4105CBP Major Facilitator EI070_04840 ENOG4105EGI Transcriptional regulator EI070_04845 ENOG4108ETY sodium dicarboxylate symporter EI070_04850 ENOG4105JAB phenazine biosynthesis protein, phzf family EI070_04880 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EI070_04895 ENOG4105D3G Pseudouridine synthase EI070_04900 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) EI070_04915 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EI070_04940 ENOG4108JPW Aminotransferase EI070_04945 ENOG4105DY8 decarboxylase EI070_04955 ENOG4105F7P transcriptional regulator AsnC family EI070_04960 ENOG4107RA9 decarboxylase EI070_04965 ENOG4105C85 amino acid EI070_04970 ENOG4105CVA phosphate EI070_04975 ENOG4105C8U phosphate abc transporter EI070_04985 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EI070_04990 ENOG4105ERU peptidase EI070_05005 ENOG4107QTF adenylosuccinate lyase EI070_05025 ENOG4108Z0R Transferase EI070_05030 ENOG4105DZ1 carboxypeptidase EI070_05050 ENOG4108K5P (LipO)protein EI070_05055 ENOG4105EJC lysr family transcriptional regulator EI070_05060 ENOG4105DAN ATP-dependent protease EI070_05075 ENOG4105DHU Bile acid EI070_05095 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EI070_05105 ENOG4105D22 carbon starvation protein EI070_05110 ENOG4105VCD cytoplasmic protein EI070_05145 ENOG4108K8K Transcriptional regulator EI070_05160 ENOG4105C26 Dehydrogenase EI070_05165 ENOG4105C85 amino acid EI070_05170 ENOG4105ETT transcriptional Regulator, LysR family EI070_05175 ENOG4105C94 Transporter EI070_05180 ENOG4105C94 Transporter EI070_05190 ENOG4105C26 Dehydrogenase EI070_05195 ENOG4107QZF nitrite reductase NADPH large subunit EI070_05200 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) EI070_05230 ENOG41060M8 Pfam:PhdYeFM EI070_05235 ENOG4107QNK )-transporter EI070_05240 ENOG4107WEA mandelate racemase muconate lactonizing EI070_05250 ENOG4105J7D transcriptional regulator EI070_05270 ENOG4105C2I pirin domain protein EI070_05280 ENOG4105WWK YheO domain protein EI070_05295 ENOG4105CEY Amp-dependent synthetase and ligase EI070_05310 ENOG4108IPW abc transporter atp-binding protein EI070_05330 ENOG4105C0W non-ribosomal peptide synthetase EI070_05335 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EI070_05340 ENOG4105WQI isochorismatase EI070_05355 ENOG4105BZ1 (ABC) transporter EI070_05375 ENOG4105E4F Isochorismate synthase EI070_05390 ENOG4105NX3 Membrane EI070_05415 ENOG4105EUJ GTP cyclohydrolase i EI070_05425 ENOG4105C7W Xanthine dehydrogenase EI070_05455 ENOG4105CD8 aminopeptidase N EI070_05460 ENOG4105DDQ anthranilate synthase EI070_05550 ENOG4105CDU Replicative dna helicase EI070_05780 ENOG4105DFP Integrase EI070_05790 ENOG4105DUX Transporter EI070_05795 ENOG4105C5F glutamine synthetase EI070_05805 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) EI070_05840 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EI070_05845 ENOG4107QNR UPF0135 protein EI070_05850 ENOG4105C0H protease EI070_05860 ENOG4105C6K Malic enzyme EI070_05865 ENOG4105BZU Histidine kinase EI070_05870 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EI070_05875 ENOG4105SYT Methylenetetrahydrofolate reductase EI070_05880 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) EI070_05895 ENOG4107QPN acyl-Coa dehydrogenase EI070_05900 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EI070_05905 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) EI070_05915 ENOG4107RNU major facilitator superfamily MFS_1 EI070_05925 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EI070_05930 ENOG4105CE9 30S ribosomal protein S2 EI070_05970 ENOG4105CVE Lytic murein transglycosylase EI070_05975 ENOG4105CNI cell division protein FtsW EI070_05990 ENOG4105E3A (ABC) transporter EI070_05995 ENOG4105DA5 (ABC) transporter EI070_06030 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EI070_06040 ENOG4105ENT Efflux transporter rnd family, mfp subunit EI070_06050 ENOG4105E89 ABC transporter EI070_06055 ENOG4105DSP amino acid AbC transporter EI070_06060 ENOG4106YG3 ABC transporter EI070_06065 ENOG4108JEH abc transporter atp-binding protein EI070_06075 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding EI070_06080 ENOG4105CFP Peptidase U32 EI070_06085 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EI070_06090 ENOG4105JAB phenazine biosynthesis protein, phzf family EI070_06095 ENOG4105DP0 ferredoxin-NADP reductase EI070_06100 ENOG4108R96 Methyltransferase, YaeB family EI070_06110 ENOG4107QHF type ii secretion system protein e EI070_06120 ENOG4105XJC Two component transcriptional regulator (Winged helix family EI070_06125 ENOG4105DHQ Histidine kinase EI070_06135 ENOG4105M6F mutator MutT protein EI070_06145 ENOG4105BZ4 penicillin-binding protein EI070_06150 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EI070_06155 ENOG4105VUT cytoplasmic protein EI070_06160 ENOG4107QYG anthranilate phosphoribosyltransferase EI070_06170 ENOG4105CK2 sodium dicarboxylate symporter EI070_06175 ENOG4105C1G acyl-Coa dehydrogenase EI070_06180 ENOG4105NIV Esterase EI070_06185 ENOG4105CQC Prephenate dehydratase EI070_06190 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EI070_06200 ENOG4105CIN aminoacyl-histidine dipeptidase EI070_06205 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EI070_06235 ENOG4105M08 Membrane EI070_06240 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EI070_06250 ENOG4105VEQ Cold shock protein EI070_06255 ENOG4105C1J atp-dependent rna helicase EI070_06265 ENOG41069NU Nitroreductase EI070_06300 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase EI070_06315 ENOG4105C5I Dehydrogenase EI070_06320 ENOG4105ERG peptidase m48, ste24p EI070_06325 ENOG4105KTH gatB Yqey EI070_06330 ENOG4105VCC 30S ribosomal protein S21 EI070_06355 ENOG4105D9P serine threonine protein kinase EI070_06380 ENOG4105EVZ LysR family transcriptional regulator EI070_06385 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EI070_06390 ENOG4105C26 Dehydrogenase EI070_06425 ENOG4105H4F exported protein EI070_06455 ENOG4105D6U Sodium Glutamate Symporter EI070_06465 ENOG4105JXH GntR family transcriptional regulator EI070_06515 ENOG4105CSH Transporter EI070_06540 ENOG4105CEB Aspartate aminotransferase EI070_06555 ENOG4105F1S paraquat-inducible protein a EI070_06560 ENOG4105DY2 Paraquat-inducible protein b EI070_06660 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EI070_06735 ENOG4105CK2 sodium dicarboxylate symporter EI070_06745 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EI070_06750 ENOG4108UMI ABC transporter, permease EI070_06755 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EI070_06765 ENOG4105C12 Phosphoribosylglycinamide synthetase EI070_06770 ENOG4105DC1 bifunctional purine biosynthesis protein purh EI070_06775 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) EI070_06825 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EI070_06830 ENOG4105CDU Replicative dna helicase EI070_06855 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) EI070_06860 ENOG4105CCU oxidase (Subunit III) EI070_06865 ENOG4105BZ9 Cytochrome C oxidase, subunit I EI070_06870 ENOG4105E2S oxidase) subunit II EI070_06895 ENOG4107BJW polysaccharide deacetylase EI070_06900 ENOG4105CND Glycosyl transferase, family 2 EI070_06905 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD EI070_06915 ENOG4105DEN Luciferase family EI070_06935 ENOG4105CC0 LysR family Transcriptional regulator EI070_06950 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EI070_06955 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EI070_06960 ENOG4105GVF (ABC) transporter EI070_06975 ENOG4105C1G acyl-Coa dehydrogenase EI070_06985 ENOG4108MEJ flavin reductase domain protein EI070_06990 ENOG4105D06 uba thif-type nad fad binding protein EI070_07010 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EI070_07015 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EI070_07025 ENOG4105C08 Histidine kinase EI070_07030 ENOG4105EEX Two component transcriptional regulator (Winged helix family EI070_07035 ENOG4105CFQ glutamine synthetase EI070_07050 ENOG4107S74 Lysophospholipid transporter LplT EI070_07055 ENOG4105CFU surface antigen EI070_07075 ENOG4107QIJ Aconitate hydratase 2 EI070_07085 ENOG4105EYW Ion transport protein EI070_07090 ENOG4105F27 Major Facilitator EI070_07105 ENOG4105DZ2 Transcriptional regulator EI070_07140 ENOG4105K8N protein family UPF0079, ATPase EI070_07145 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EI070_07155 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EI070_07160 ENOG4108TZV Membrane EI070_07165 ENOG4108RCM Nitroreductase EI070_07175 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) EI070_07190 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EI070_07195 ENOG4107FQ9 ethanolamine ammonia-lyase EI070_07200 ENOG4105CPD ethanolamine ammonia-lyase EI070_07205 ENOG4107R55 ethanolamine transporter EI070_07215 ENOG4107RR1 TRANSCRIPTIONal EI070_07225 ENOG4105C0A alcohol dehydrogenase EI070_07230 ENOG4107QUV Domain protein EI070_07240 ENOG4105F4I Transcriptional regulator EI070_07260 ENOG4105CD8 aminopeptidase N EI070_07270 ENOG4105EMU Dehydrogenase EI070_07280 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) EI070_07285 ENOG4105EW9 transcriptional regulator AsnC family EI070_07300 ENOG4105R8C Transcriptional regulator EI070_07310 ENOG4105CUY Mechanosensitive ion channel EI070_07345 ENOG4105CNM Receptor EI070_07365 ENOG4105C5H ABC transporter EI070_07370 ENOG41081QV Universal stress protein EI070_07385 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EI070_07395 ENOG4105DKK Benzoate EI070_07400 ENOG4105EW9 transcriptional regulator AsnC family EI070_07405 ENOG4108NIW Leucine export protein LeuE EI070_07410 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EI070_07415 ENOG4105C5Q Transcriptional regulator EI070_07425 ENOG4105CHU acetyl-coa acetyltransferase EI070_07430 ENOG4105CHR reductase EI070_07455 ENOG4107QMP dna polymerase iii subunits gamma and tau EI070_07460 ENOG4105HSS phospholipase C EI070_07470 ENOG4105C0A alcohol dehydrogenase EI070_07500 ENOG4105CBC glutamate synthase EI070_07780 ENOG4105UPP uncharacterized protein ydcA EI070_07810 ENOG4105DR5 peptidase EI070_07905 ENOG4105D8G Major Facilitator superfamily EI070_07915 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EI070_07920 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein EI070_07945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EI070_07955 ENOG4107QZF nitrite reductase NADPH large subunit EI070_07960 ENOG4108IFG nitrite reductase, (NAD(P)H) EI070_07980 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EI070_07995 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EI070_08000 ENOG4105CVM Molybdenum cofactor synthesis domain protein EI070_08010 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EI070_08015 ENOG4105T38 integral membrane protein EI070_08035 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) EI070_08040 ENOG4105CMR udp-glucose 4-epimerase EI070_08115 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EI070_08120 ENOG4105CUX Signal transduction histidine kinase EI070_08145 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EI070_08150 ENOG4105KNE Phosphatidate cytidylyltransferase EI070_08160 ENOG4105DZP Membrane-associated zinc metalloprotease EI070_08185 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EI070_08200 ENOG4105Y3E Modulates RecA activity (By similarity) EI070_08210 ENOG4105VEJ Heat shock protein EI070_08215 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 EI070_08240 ENOG4105F7P transcriptional regulator AsnC family EI070_08250 ENOG4105C85 amino acid EI070_08265 ENOG4105CHH sulfate transporter EI070_08270 ENOG4108RAV Conserved protein EI070_08275 ENOG4105D8V Glucose sorbosone dehydrogenase EI070_08285 ENOG4105BZU Histidine kinase EI070_08305 ENOG4105DM4 PTS System EI070_08310 ENOG4105DE4 1-phosphofructokinase EI070_08315 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EI070_08340 ENOG4105CWM branched-chain amino acid transport system II carrier protein EI070_08345 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EI070_08350 ENOG4105CC0 LysR family Transcriptional regulator EI070_08360 ENOG4105M2J Glutaredoxin EI070_08365 ENOG4105C8Y Acetylornithine aminotransferase EI070_08370 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EI070_08395 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EI070_08405 ENOG41068P6 UPF0319 protein EI070_08425 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EI070_08430 ENOG4105C4M (Ubiquinol oxidase) subunit I EI070_08440 ENOG4105PV3 Inner membrane protein yqiJ EI070_08455 ENOG4105E0K tonB-dependent siderophore receptor EI070_08465 ENOG4105HDD phospholipase EI070_08470 ENOG4105CZN Potassium uptake protein EI070_08480 ENOG4105C7B Threonine dehydratase EI070_08510 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EI070_08515 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EI070_08525 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EI070_08540 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EI070_08585 ENOG4107VMU Membrane EI070_08590 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) EI070_08600 ENOG4107QP7 CoA-transferase subunit A EI070_08605 ENOG4107QNJ CoA-transferase subunit B EI070_08610 ENOG4105CHU acetyl-coa acetyltransferase EI070_08615 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase EI070_08620 ENOG4105F2Z 3-oxoadipate enol-lactonase EI070_08625 ENOG4105D2S major facilitator superfamily EI070_08630 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EI070_08635 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta EI070_08640 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha EI070_08645 ENOG4105FF2 Type I DHQase EI070_08650 ENOG4106JPM 3-dehydroshikimate dehydratase EI070_08655 ENOG4105TW1 Carbohydrate-selective porin OprB EI070_08660 ENOG4105DZG Dehydrogenase EI070_08670 ENOG4105MD1 YeeE YedE family protein EI070_08685 ENOG4107HP6 Transcriptional regulator EI070_08690 ENOG4108PTX LysR family Transcriptional regulator EI070_08695 ENOG4105C1G acyl-Coa dehydrogenase EI070_08720 ENOG4105DNH Major Facilitator EI070_08730 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EI070_08750 ENOG4105FUY alpha subunit EI070_08760 ENOG4105CHR reductase EI070_08780 ENOG4105F11 amine oxidase EI070_08790 ENOG4105C26 Dehydrogenase EI070_08800 ENOG4105F2Z 3-oxoadipate enol-lactonase EI070_08805 ENOG4105CHU acetyl-coa acetyltransferase EI070_08810 ENOG4107QNJ CoA-transferase subunit B EI070_08815 ENOG4107QP7 CoA-transferase subunit A EI070_08825 ENOG4105NN7 muconolactone delta-isomerase EI070_08830 ENOG4105DTQ mandelate racemase muconate lactonizing EI070_08835 ENOG4108KB2 LysR family Transcriptional regulator EI070_08845 ENOG4107EJG GntR family transcriptional regulator EI070_08865 ENOG4105CZJ Aldehyde dehydrogenase EI070_08885 ENOG4105C1G acyl-Coa dehydrogenase EI070_08895 ENOG4108JU7 Transcriptional regulator EI070_08905 ENOG41062QD Membrane EI070_08920 ENOG4107RGH Aldehyde dehydrogenase EI070_08935 ENOG4105CH6 catalase EI070_08960 ENOG4105K56 Transcriptional regulator EI070_08965 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EI070_08975 ENOG4105NAE bifunctional deaminase-reductase domain protein EI070_09005 ENOG4107Z3H Transcriptional regulator, TetR family EI070_09015 ENOG4105CHJ isochorismatase hydrolase EI070_09020 ENOG4105EJC lysr family transcriptional regulator EI070_09025 ENOG4105D8V Glucose sorbosone dehydrogenase EI070_09030 ENOG4105CKD glutathione-regulated potassium-efflux system protein EI070_09040 ENOG4105CH2 amidohydrolase EI070_09055 ENOG4105D5K Hemolysin activator protein EI070_09060 ENOG4105CKT filamentous hemagglutinin EI070_09090 ENOG4105FDP GntR family transcriptional regulator EI070_09115 ENOG4106KR7 LysR family Transcriptional regulator EI070_09140 ENOG4108JQ1 Dehydrogenase EI070_09145 ENOG4105JSC dimethylmenaquinone methyltransferase EI070_09165 ENOG4105CW7 secretion protein, HlyD family EI070_09180 ENOG4105CZJ Aldehyde dehydrogenase EI070_09185 ENOG4105C01 Dihydroxy-acid dehydratase EI070_09195 ENOG4105DDW LysR family Transcriptional regulator EI070_09200 ENOG4105EXW epimerase dehydratase EI070_09210 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EI070_09215 ENOG4105CF7 AraC family transcriptional regulator EI070_09230 ENOG4105DQ4 alcohol dehydrogenase EI070_09240 ENOG4105EHG Permease protein EI070_09245 ENOG4105E0A ABC, transporter EI070_09265 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EI070_09345 ENOG4108UAJ Transcriptional regulator EI070_09385 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) EI070_09440 ENOG4108BAS reductase EI070_09455 ENOG4108R6W Transcriptional regulator, ARAC family EI070_09460 ENOG4108821 RND type efflux pump EI070_09465 ENOG4105E0F Histidine kinase EI070_09470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EI070_09475 ENOG4105C1P efflux transporter, rnd family, mfp subunit EI070_09480 ENOG4105BZS acriflavin resistance protein EI070_09485 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EI070_09495 ENOG4105CT3 Monooxygenase EI070_09515 ENOG4105CJP fad dependent oxidoreductase EI070_09535 ENOG4105X0I Fimbrial EI070_09590 ENOG4107RZC phospholipase d EI070_09610 ENOG4108IGT Dipeptidase EI070_09645 ENOG4107T31 5'-nucleotidase EI070_09655 ENOG4105WQI isochorismatase EI070_09660 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EI070_09665 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) EI070_09670 ENOG4105E0C molybdate abc transporter EI070_09675 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EI070_09680 ENOG4105F4R Transcriptional regulator mode EI070_09685 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit EI070_09690 ENOG4108YS2 small subunit EI070_09695 ENOG4105F57 Anthranilate dioxygenase reductase EI070_09720 ENOG4105CHR reductase EI070_09730 ENOG4105D2S major facilitator superfamily EI070_09735 ENOG4105CF7 AraC family transcriptional regulator EI070_09745 ENOG4105DTD Dehydrogenase EI070_09750 ENOG4105CY2 Citrate transporter EI070_09760 ENOG4108M0I Transcriptional regulator EI070_09770 ENOG4107QNJ CoA-transferase subunit B EI070_09775 ENOG4105CRW Short chain fatty acid transporter EI070_09780 ENOG4105CHU acetyl-coa acetyltransferase EI070_09790 ENOG4107YNJ LysR family Transcriptional regulator EI070_09805 ENOG4108IJ0 Aspartate ammonia-lyase EI070_09815 ENOG4105CSH Transporter EI070_09835 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EI070_09840 ENOG4106FTQ Taurine ABC transporter, periplasmic EI070_09855 ENOG4105FDP GntR family transcriptional regulator EI070_09865 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EI070_09870 ENOG4105KVH Transcriptional regulator EI070_09875 ENOG4105UEI Transcriptional Regulator AraC Family EI070_09890 ENOG4108VCT Sulfite exporter TauE/SafE EI070_09900 ENOG4107QPB Beta-lactamase domain protein EI070_09910 ENOG4105FFC UPF0187 protein EI070_09920 ENOG4105CHR reductase EI070_09935 ENOG4105CPP Dehydrogenase, E1 component EI070_09940 ENOG4107R0V Pyruvate dehydrogenase EI070_09945 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EI070_09960 ENOG4105BZU Histidine kinase EI070_09970 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) EI070_09975 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EI070_10020 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EI070_10035 ENOG4105C28 cystathionine EI070_10045 ENOG4105F2W methyltransferase EI070_10075 ENOG4105K59 histidine triad (HIT) protein EI070_10100 ENOG4107QWP ABC-2 type transporter EI070_10105 ENOG4107QWP ABC-2 type transporter EI070_10110 ENOG4105CJ1 ABC, transporter EI070_10125 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EI070_10130 ENOG4105CNM Receptor EI070_10150 ENOG4107TSN permease EI070_10155 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EI070_10175 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EI070_10180 ENOG4108YZT Adenosylcobinamide kinase EI070_10235 ENOG4105DJU Siderophore biosynthesis protein EI070_10240 ENOG4105DUU IucA IucC family protein EI070_10260 ENOG4108Z66 YbaK ebsC protein EI070_10275 ENOG4105C1G acyl-Coa dehydrogenase EI070_10280 ENOG4105C1G acyl-Coa dehydrogenase EI070_10285 ENOG4105EEF Alkane 1-monooxygenase EI070_10290 ENOG4105E7U AraC family transcriptional regulator EI070_10295 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) EI070_10300 ENOG4105K70 DNA-binding protein EI070_10315 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family EI070_10325 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins EI070_10330 ENOG4108Z4V iron-sulfur cluster assembly EI070_10345 ENOG4108ZIT Ferredoxin, 2FE-2S EI070_10350 ENOG4105F8J Adenylate Guanylate cyclase EI070_10360 ENOG4108JA2 transcriptioN-repair coupling factor EI070_10380 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) EI070_10385 ENOG4105K4T epimerase EI070_10400 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase EI070_10420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EI070_10430 ENOG4105DGW oligopeptidase A EI070_10470 ENOG4105SG9 biopolymer transport protein, ExbD EI070_10480 ENOG4107QP3 malate synthase g EI070_10485 ENOG4105D6Z AFG1 family ATPase EI070_10495 ENOG4107RN6 Monooxygenase EI070_10515 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) EI070_10520 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EI070_10535 ENOG4108Z6B deaminase EI070_10555 ENOG4108RTD type II secretion system protein K EI070_10580 ENOG4105F8V Hydrolase, tatD family EI070_10590 ENOG4107QRG dna polymerase iii EI070_10600 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) EI070_10605 ENOG4105BZ1 (ABC) transporter EI070_10620 ENOG4105FA0 parb-like partition protein EI070_10625 ENOG4107QJE Chromosome Partitioning Protein EI070_10635 ENOG4108S0S Nucleotidyl transferase EI070_10640 ENOG4105EHM Aminoglycoside phosphotransferase EI070_10645 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) EI070_10650 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) EI070_10655 ENOG4105D2N Aldolase EI070_10675 ENOG4108UHJ MAF-like protein EI070_10680 ENOG4105EZE Cupin 4 family protein EI070_10690 ENOG41080HT Transcriptional regulator, arsr family EI070_10700 ENOG4105XPP Protein of unknown function (DUF1275) EI070_10705 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme EI070_10710 ENOG4105BZ1 (ABC) transporter EI070_10720 ENOG4108ZX5 transcriptional regulator EI070_10730 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EI070_10735 ENOG4105CK7 Sodium proline symporter EI070_10740 ENOG4105EW9 transcriptional regulator AsnC family EI070_10745 ENOG4105C26 Dehydrogenase EI070_10750 ENOG4105YGK Pfam:UPF0157 EI070_10765 ENOG4108T58 Mg2 transport protein CorA EI070_10775 ENOG4107RYR Transcriptional regulator, Crp Fnr family EI070_10780 ENOG4108UKZ OsmC family EI070_10795 ENOG4108YYC ycei family EI070_10805 ENOG4105CV1 Transketolase (EC 2.2.1.1) EI070_10830 ENOG4108HWY Beta-lactamase EI070_10850 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EI070_10855 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EI070_10875 ENOG4105X0I Fimbrial EI070_10880 ENOG4105GQR Chaperone EI070_10910 ENOG4108IPJ Membrane EI070_10920 ENOG4105ETS cytosine purines uracil thiamine allantoin EI070_10930 ENOG4105CC0 LysR family Transcriptional regulator EI070_10950 ENOG41067SE Tetr family transcriptional regulator EI070_10965 ENOG4105EW9 transcriptional regulator AsnC family EI070_10975 ENOG4105CDA abc transporter atp-binding protein EI070_10980 ENOG4105DRP amino acid AbC transporter EI070_10985 ENOG4105EAD ABC transporter EI070_11000 ENOG4107T8P acyl-Coa dehydrogenase EI070_11015 ENOG4105D01 (LipO)protein EI070_11020 ENOG4105D01 (LipO)protein EI070_11025 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EI070_11030 ENOG4108UMI ABC transporter, permease EI070_11035 ENOG4105C3G gtp-binding protein EI070_11060 ENOG4108UMN azlc family EI070_11065 ENOG4105ZED uncharacterized protein ygaH EI070_11095 ENOG4105E7U AraC family transcriptional regulator EI070_11100 ENOG4108V06 Glutathione peroxidase EI070_11110 ENOG4105CHM Aminotransferase EI070_11125 ENOG4105C0B DNA polymerase III (alpha subunit) EI070_11150 ENOG4108JU3 Alkyl hydroperoxide reductase EI070_11165 ENOG4108KB2 LysR family Transcriptional regulator EI070_11170 ENOG4105D6J arsenicaL-resistance protein EI070_11175 ENOG41082YX Transcriptional regulator, arsr family EI070_11190 ENOG4105CPN adenine deaminase EI070_11200 ENOG4105CBN LysR family transcriptional regulator EI070_11215 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EI070_11225 ENOG4105E2B Taurine dioxygenase EI070_11230 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EI070_11235 ENOG4108IY8 ABC, transporter EI070_11240 ENOG4106FTQ Taurine ABC transporter, periplasmic EI070_11250 ENOG4105C54 Major Facilitator superfamily EI070_11275 ENOG4105C4M (Ubiquinol oxidase) subunit I EI070_11280 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EI070_11290 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EI070_11295 ENOG4108K70 Transcriptional regulator EI070_11310 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EI070_11315 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase EI070_11330 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) EI070_11335 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase EI070_11345 ENOG4105DXI Major Facilitator superfamily EI070_11365 ENOG41067MG lrgb family EI070_11370 ENOG4105VAW lrga family EI070_11375 ENOG4105CMU LysR family (Transcriptional regulator EI070_11380 ENOG4108SHQ Glutathione S-transferase EI070_11385 ENOG4105CYM Glutathione S-transferase EI070_11390 ENOG4105CBN LysR family transcriptional regulator EI070_11395 ENOG4105CHR reductase EI070_11405 ENOG4105D7W serine acetyltransferase EI070_11410 ENOG4105ESN nucleotide-binding protein EI070_11415 ENOG4105C9B Cysteine desulfurase EI070_11430 ENOG4105EXG Transcriptional regulator EI070_11440 ENOG4105CT1 (ABC) transporter EI070_11445 ENOG4107RP9 extracellular solute-binding protein, family 3 EI070_11450 ENOG4105CDA abc transporter atp-binding protein EI070_11455 ENOG4108HW4 amino acid AbC transporter EI070_11460 ENOG4105EAD ABC transporter EI070_11475 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EI070_11480 ENOG4105BZU Histidine kinase EI070_11490 ENOG4105EW9 transcriptional regulator AsnC family EI070_11500 ENOG4105KT5 UmuD protein EI070_11520 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EI070_11565 ENOG4105HEI LysR family (Transcriptional regulator EI070_11585 ENOG4105CEY Amp-dependent synthetase and ligase EI070_11590 ENOG4105R8C Transcriptional regulator EI070_11595 ENOG4105C1G acyl-Coa dehydrogenase EI070_11600 ENOG4107QX3 carboxylase EI070_11605 ENOG4105E39 Enoyl-CoA hydratase EI070_11620 ENOG4105CC0 LysR family Transcriptional regulator EI070_11635 ENOG4105CSU acyl-Coa dehydrogenase EI070_11645 ENOG4105EQ0 Major Facilitator superfamily EI070_11655 ENOG4107QNJ CoA-transferase subunit B EI070_11660 ENOG4107QP7 CoA-transferase subunit A EI070_11665 ENOG4107RGD Major Facilitator superfamily EI070_11670 ENOG4105C1G acyl-Coa dehydrogenase EI070_11675 ENOG4105E39 Enoyl-CoA hydratase EI070_11680 ENOG4105CHR reductase EI070_11685 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EI070_11690 ENOG4105CHU acetyl-coa acetyltransferase EI070_11700 ENOG4105EQ0 Major Facilitator superfamily EI070_11705 ENOG4105EA8 2-Nitropropane dioxygenase EI070_11710 ENOG4108UKI Enoyl-CoA hydratase EI070_11725 ENOG4105C1G acyl-Coa dehydrogenase EI070_11730 ENOG4107RGD Major Facilitator superfamily EI070_11735 ENOG4108KAZ Involved in phosphonate degradation (By similarity) EI070_11740 ENOG4107STF Involved in phosphonate degradation (By similarity) EI070_11750 ENOG4107RCV ABC transporter, permease EI070_11755 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EI070_11760 ENOG4105C4Y ABC transporter EI070_11795 ENOG4107R4J Chloride channel EI070_11800 ENOG4108JIK carboxylase EI070_11820 ENOG4105C5A transporter EI070_11825 ENOG4108WAV Transcriptional regulator EI070_11840 ENOG4105CNA YD repeat protein EI070_11880 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) EI070_11900 ENOG4105D2S major facilitator superfamily EI070_11915 ENOG4105D1S lipid A biosynthesis EI070_11920 ENOG4105BZU Histidine kinase EI070_11925 ENOG4107AQZ Membrane EI070_11945 ENOG4108Z4U Ferredoxin EI070_11985 ENOG4105DFG type I secretion outer membrane protein EI070_11990 ENOG4108IUZ ABC transporter EI070_11995 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA EI070_12005 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase EI070_12010 ENOG4105C2X Arabinose 5-phosphate isomerase EI070_12045 ENOG4107YPT transcriptional regulator EI070_12080 ENOG4105II7 pyrroline-5-carboxylate reductase EI070_12090 ENOG4105VEQ Cold shock protein EI070_12095 ENOG410829K Lysine exporter protein (Lyse ygga) EI070_12130 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EI070_12185 ENOG4108KB2 LysR family Transcriptional regulator EI070_12190 ENOG4105FUY alpha subunit EI070_12195 ENOG4108UKV benzoate 1,2-dioxygenase EI070_12200 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein EI070_12205 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase EI070_12210 ENOG4105DKK Benzoate EI070_12215 ENOG4105D2S major facilitator superfamily EI070_12230 ENOG4105CQ7 ATP-dependent helicase EI070_12235 ENOG4105D3R alkyl hydroperoxide reductase EI070_12245 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EI070_12255 ENOG4108JU3 Alkyl hydroperoxide reductase EI070_12265 ENOG4108K3A Glutathione S-transferase EI070_12275 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EI070_12280 ENOG4108TGY Glutathione S-transferase EI070_12290 ENOG4108ZG0 Ompa motb domain protein EI070_12295 ENOG4105CD3 dihydroorotase EI070_12325 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EI070_12345 ENOG4108UKZ OsmC family EI070_12350 ENOG4107RYR Transcriptional regulator, Crp Fnr family EI070_12360 ENOG4105CPC Aldo Keto reductase EI070_12375 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EI070_12385 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EI070_12395 ENOG4105CFH Aspartokinase EI070_12405 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EI070_12415 ENOG4105CPW cytochrome b561 EI070_12420 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EI070_12425 ENOG4105C7N Xanthine uracil vitamin C permease EI070_12435 ENOG4105F95 Monooxygenase EI070_12460 ENOG4108C33 Resolvase EI070_12500 ENOG4105C85 amino acid EI070_12520 ENOG4105C26 Dehydrogenase EI070_12540 ENOG4105CUB amino acid EI070_12550 ENOG4105C85 amino acid EI070_12595 ENOG4105CNA YD repeat protein EI070_12615 ENOG4105D01 (LipO)protein EI070_12620 ENOG4108M3P Membrane EI070_12635 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EI070_12655 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) EI070_12675 ENOG4108JQ5 ABC transporter EI070_12680 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component EI070_12685 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component EI070_12695 ENOG4105E9H Lytic Murein transglycosylase EI070_12695 ENOG4105E9H Lytic Murein transglycosylase EI070_12700 ENOG4107RZZ dna polymerase iii epsilon subunit EI070_12710 ENOG4105E09 nadh pyrophosphatase EI070_12720 ENOG4105W4M Transport-associated protein EI070_12730 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EI070_12740 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) EI070_12745 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EI070_12765 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family EI070_12770 ENOG4105D0A hydroxylase EI070_12775 ENOG4107RAQ aminopeptidase EI070_12810 ENOG4105DIJ Phosphoethanolamine transferase EI070_12855 ENOG4105DR5 peptidase EI070_13180 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EI070_13205 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EI070_13215 ENOG4105D82 Glutamate dehydrogenase EI070_13220 ENOG4108R3D Electron transport complex EI070_13225 ENOG4105CSM endonuclease III EI070_13250 ENOG4105CJN penicillin-binding protein EI070_13255 ENOG4106H78 methyltransferase EI070_13270 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) EI070_13280 ENOG4105CQM Urea amidohydrolase subunit alpha EI070_13310 ENOG4107RET Isocitrate lyase EI070_13320 ENOG4105C37 (CBS) domain EI070_13330 ENOG4105D4T Citrate transporter EI070_13345 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) EI070_13360 ENOG4108MRJ EI070_13380 ENOG4105VCQ rubredoxin EI070_13385 ENOG4107QZF nitrite reductase NADPH large subunit EI070_13395 ENOG4105C5Q Transcriptional regulator EI070_13415 ENOG4107U91 Rhomboid family EI070_13420 ENOG4105CV6 ABC transporter, permease EI070_13425 ENOG4108I0Y (ABC) transporter EI070_13430 ENOG4108UJV acyl-CoA thioesterase i EI070_13450 ENOG4107RNH Outer membrane receptor FepA EI070_13465 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) EI070_13470 ENOG4105E6M Sulphatase-modifying factor protein EI070_13490 ENOG4105CJ3 phosphate transporter EI070_13495 ENOG4105C3R Methionine synthase EI070_13510 ENOG4105CSP Major Facilitator Superfamily EI070_13520 ENOG4108PZW LysR family Transcriptional regulator EI070_13535 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EI070_13540 ENOG4105EU0 Major facilitator Superfamily EI070_13545 ENOG4108R6W Transcriptional regulator, ARAC family EI070_13550 ENOG4105CSV Glutaminase EI070_13555 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EI070_13560 ENOG4105CSH Transporter EI070_13570 ENOG4105C7K acetolactate synthase EI070_13585 ENOG4105CHR reductase EI070_13590 ENOG4108MXF Alpha Beta Hydrolase EI070_13600 ENOG4105DJB Major Facilitator Superfamily EI070_13605 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase EI070_13615 ENOG4105CHR reductase EI070_13635 ENOG41069M3 Transcriptional regulator EI070_13650 ENOG4106YT9 Enoyl-CoA hydratase EI070_13660 ENOG4105CND Glycosyl transferase, family 2 EI070_13665 ENOG4107BJW polysaccharide deacetylase EI070_13675 ENOG4108VWS Yaeq family EI070_13685 ENOG4105CKI cobalamin synthesis protein EI070_13705 ENOG4105C94 Transporter EI070_13710 ENOG4105C94 Transporter EI070_13715 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EI070_13740 ENOG4107QK5 Homocysteine s-methyltransferase EI070_13745 ENOG4105D5Q Arginine ornithine antiporter EI070_13770 ENOG4108YNN Heme oxygenase EI070_13800 ENOG4108SF5 RNA Polymerase EI070_13810 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EI070_13815 ENOG4105C54 Major Facilitator superfamily EI070_13885 ENOG4108UUM single-stranded DNA-binding protein EI070_13930 ENOG4105DFP Integrase EI070_13950 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EI070_14035 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EI070_14075 ENOG4105K4U addiction module toxin, RelE StbE family EI070_14225 ENOG4105VTN Protein of unknown function (DUF1311) EI070_14360 ENOG41083X2 DNA polymerase III, epsilon subunit EI070_14425 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EI070_14430 ENOG4105C0R drug resistance transporter emrb qaca subfamily EI070_14435 ENOG4105CW7 secretion protein, HlyD family EI070_14440 ENOG4108VUY thioesterase Superfamily protein EI070_14445 ENOG4105D52 delta-aminolevulinic acid dehydratase EI070_14450 ENOG4105MWK D-amino acid dehydrogenase, small subunit EI070_14455 ENOG4105ECP epimerase EI070_14475 ENOG4107RH8 nuclease SbcCD subunit D EI070_14480 ENOG4105EYH Exonuclease EI070_14485 ENOG4105DFA alanine racemase domain protein EI070_14490 ENOG4105CZX twitching motility protein EI070_14495 ENOG4105CZX twitching motility protein EI070_14500 ENOG41090R7 Ferric uptake EI070_14530 ENOG4105E7A Glutamine amidotransferase EI070_14545 ENOG4107QKV phosphomannomutase EI070_14555 ENOG4105C4R Atp-dependent dna helicase EI070_14560 ENOG4108ZG0 Ompa motb domain protein EI070_14565 ENOG4106HNH Acyl-transferase EI070_14580 ENOG4107QMS site-determining protein EI070_14610 ENOG4105CNU cell division protein FtsK EI070_14615 ENOG4105C3M thioredoxin reductase EI070_14620 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) EI070_14630 ENOG4105KEG ribosomal-protein-alanine acetyltransferase EI070_14675 ENOG4108YXA Membrane EI070_14680 ENOG4105EUB pirin domain protein EI070_14690 ENOG4105C4K Nad synthetase EI070_14705 ENOG4105E3J oxidoreductase EI070_14710 ENOG4105C26 Dehydrogenase EI070_14715 ENOG4105DVW rieske (2Fe-2S) EI070_14725 ENOG4105C94 Transporter EI070_14730 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EI070_14735 ENOG4105EJC lysr family transcriptional regulator EI070_14755 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding EI070_14775 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EI070_14780 ENOG4105C34 Pseudouridine synthase EI070_14785 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EI070_14790 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EI070_14805 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) EI070_14835 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EI070_14865 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EI070_14875 ENOG4105DWF phosphomethylpyrimidine kinase EI070_14880 ENOG4109066 lysm domain bon superfamily protein EI070_14890 ENOG4105CHR reductase EI070_14895 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EI070_14905 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein EI070_14910 ENOG4108BPE -transporting atpase EI070_14915 ENOG4107RTD sua5 ycio yrdc ywlc family protein EI070_14920 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EI070_14925 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EI070_14930 ENOG4105FE9 pseudouridine synthase EI070_14940 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EI070_14945 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EI070_14955 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EI070_14960 ENOG4108K4C ec 3.1.3.12 EI070_14965 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase EI070_14970 ENOG4106UW1 Major Facilitator superfamily EI070_14990 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EI070_15000 ENOG4105HF0 Membrane EI070_15015 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY EI070_15025 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) EI070_15085 ENOG4105D1F ATP-binding protein EI070_15095 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EI070_15125 ENOG4105K6H D-cysteine desulfhydrase EI070_15130 ENOG4105CBX hi0933 family EI070_15155 ENOG4105DP0 ferredoxin-NADP reductase EI070_15160 ENOG4105DUM transcriptional regulator, lysR family EI070_15180 ENOG4105C8S subunit m EI070_15185 ENOG4105D65 subunit l EI070_15195 ENOG4107UFS subunit j EI070_15210 ENOG4108IEH NADH dehydrogenase subunit g EI070_15215 ENOG4107QIZ NADH dehydrogenase EI070_15220 ENOG4105GKE subunit e EI070_15240 ENOG4105BZU Histidine kinase EI070_15250 ENOG4105E0F Histidine kinase EI070_15255 ENOG4107EXC regulatoR EI070_15265 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EI070_15275 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EI070_15285 ENOG4105EB3 Histidine kinase EI070_15355 ENOG4105DZG Dehydrogenase EI070_15375 ENOG4105JAB phenazine biosynthesis protein, phzf family EI070_15405 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) EI070_15410 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EI070_15420 ENOG4105ETT transcriptional Regulator, LysR family EI070_15440 ENOG4105CH2 amidohydrolase EI070_15450 ENOG4106P55 Transcriptional regulator EI070_15470 ENOG4106P55 Transcriptional regulator EI070_15475 ENOG4107EFR Flavocytochrome c EI070_15485 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EI070_15490 ENOG4107RGD Major Facilitator superfamily EI070_15495 ENOG4105C1G acyl-Coa dehydrogenase EI070_15500 ENOG4105ETT transcriptional Regulator, LysR family EI070_15535 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EI070_15540 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EI070_15545 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EI070_15560 ENOG4105VR0 copper resistance EI070_15565 ENOG4105E3B Multicopper oxidase EI070_15575 ENOG4108HCJ Hydrolase EI070_15580 ENOG4105DJV ribulose-phosphate 3-epimerase EI070_15605 ENOG41072GX Peptidase M22 Glycoprotease EI070_15610 ENOG4108Z0R Transferase EI070_15665 ENOG4105CRQ synthase (Component I) EI070_15675 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EI070_15680 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EI070_15685 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EI070_15755 ENOG4105K56 Transcriptional regulator EI070_15760 ENOG4108ZHJ Organic hydroperoxide resistance protein EI070_15765 ENOG4107QHF type ii secretion system protein e EI070_15785 ENOG4105C2M dna polymerase I EI070_15790 ENOG4108VIA integral membrane protein EI070_15795 ENOG4105II7 pyrroline-5-carboxylate reductase EI070_15800 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EI070_15810 ENOG4105C9X ppx gppa phosphatase EI070_15820 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EI070_15840 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EI070_15865 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EI070_15880 ENOG4105W39 Membrane EI070_15885 ENOG4105CYM Glutathione S-transferase EI070_15905 ENOG4105CEY Amp-dependent synthetase and ligase EI070_15910 ENOG4105N42 UPF0307 protein EI070_15915 ENOG41080Z8 PHOSPHOCARRIER protein EI070_15935 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EI070_15940 ENOG4105DJ0 Poly(A) Polymerase EI070_15945 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein EI070_15950 ENOG4105DXN mazG family EI070_15960 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EI070_15975 ENOG4105C6T cysteine synthase EI070_15980 ENOG4105BZU Histidine kinase EI070_15985 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase EI070_15990 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EI070_15995 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EI070_16010 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EI070_16015 ENOG4105W8H transhydrogenase (subunit alpha EI070_16020 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EI070_16025 ENOG4106UX7 integral membrane protein EI070_16040 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EI070_16050 ENOG4107RSM transcriptional regulator EI070_16060 ENOG4105CUZ uba thif-type nad fad binding protein EI070_16070 ENOG4107QM5 aconitate hydratase EI070_16075 ENOG4105F8V Hydrolase, tatD family EI070_16090 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) EI070_16115 ENOG4105BZU Histidine kinase EI070_16125 ENOG4108ZP8 Acetolactate synthase small subunit EI070_16130 ENOG4105C7K acetolactate synthase EI070_16155 ENOG4105DJY efflux transporter, rnd family, mfp subunit EI070_16160 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EI070_16165 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EI070_16170 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EI070_16180 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) EI070_16185 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EI070_16195 ENOG4105VW4 glutaredoxin 3 EI070_16215 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EI070_16220 ENOG4105C2D reductase EI070_16230 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EI070_16260 ENOG4105C84 Histidine ammonia-lyase EI070_16275 ENOG4105CEY Amp-dependent synthetase and ligase EI070_16290 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EI070_16310 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EI070_16330 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) EI070_16350 ENOG4105WVQ Fe-S assembly protein IscX EI070_16365 ENOG4105CN1 protease EI070_16380 ENOG4106HB6 Alpha beta hydrolase EI070_16390 ENOG4105C26 Dehydrogenase EI070_16395 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EI070_16400 ENOG4105C6Z Gluconate EI070_16405 ENOG4108UHU Aldolase EI070_16410 ENOG4105C01 Dihydroxy-acid dehydratase EI070_16415 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EI070_16420 ENOG4108DNC Involved in acetate metabolism (By similarity) EI070_16425 ENOG4107GFK fumarate EI070_16445 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EI070_16455 ENOG4108ESX Receptor EI070_16465 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EI070_16475 ENOG4105DWV Homoserine O-trans-acetylase EI070_16575 ENOG4105CIY formyltetrahydrofolate deformylase EI070_16585 ENOG4107RGH Aldehyde dehydrogenase EI070_16590 ENOG4105KDC 50s ribosomal protein l28 EI070_16595 ENOG4105W0E 50S ribosomal protein L33 EI070_16600 ENOG4105CKD glutathione-regulated potassium-efflux system protein EI070_16620 ENOG4105VFU Rna-binding protein EI070_16625 ENOG4105C4R Atp-dependent dna helicase EI070_16640 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EI070_16650 ENOG4105KVH Transcriptional regulator EI070_16660 ENOG41069P5 Protein slyX homolog EI070_16665 ENOG4105C5H ABC transporter EI070_16670 ENOG4105N14 lysine exporter protein LysE YggA EI070_16675 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase EI070_16685 ENOG4105CK2 sodium dicarboxylate symporter EI070_16740 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EI070_16765 ENOG4105DUM transcriptional regulator, lysR family EI070_16790 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase EI070_16805 ENOG4108W5M transcriptional regulator EI070_16820 ENOG4105D29 Helix-turn-helix type 11 domain protein EI070_16825 ENOG4107XGZ Hydrolase EI070_16830 ENOG4105EI2 Pseudouridine synthase EI070_16840 ENOG4105C03 ribonuclease EI070_16860 ENOG4105CBN LysR family transcriptional regulator EI070_16865 ENOG4105EMU Dehydrogenase EI070_16870 ENOG4105CSA Coproporphyrinogen iii oxidase EI070_16880 ENOG4107QI1 Mate efflux family protein EI070_16890 ENOG4107T8P acyl-Coa dehydrogenase EI070_16935 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) EI070_16940 ENOG4105C5X domain protein EI070_16955 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EI070_16965 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase EI070_16970 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) EI070_16975 ENOG4108JU5 Magnesium and cobalt efflux protein EI070_16980 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EI070_16985 ENOG4108Z7R Chaperone CsaA EI070_16995 ENOG4108VAU general secretion pathway protein G EI070_17000 ENOG4105D7Q type ii secretion system EI070_17005 ENOG4105C25 Primosomal protein n' EI070_17010 ENOG4105CKD glutathione-regulated potassium-efflux system protein EI070_17015 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EI070_17025 ENOG4105DVC DnaJ domain protein EI070_17030 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) EI070_17035 ENOG4107QUT magnesium and cobalt transport protein CorA EI070_17055 ENOG4107QYX exodeoxyribonuclease v alpha EI070_17060 ENOG4107QKA exodeoxyribonuclease V beta EI070_17065 ENOG4105DSY exodeoxyribonuclease V, gamma EI070_17075 ENOG4105CSR polyphosphate kinase 2 EI070_17085 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EI070_17100 ENOG41061H0 Monooxygenase EI070_17105 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EI070_17120 ENOG4105D65 subunit l EI070_17125 ENOG4108ZE9 Monovalent cation H antiporter subunit C EI070_17130 ENOG4107R4Z monovalent cation h antiporter subunit d EI070_17135 ENOG4105SC1 monovalent cation H antiporter subunit E EI070_17140 ENOG4105W4C monovalent cation H antiporter subunit F EI070_17145 ENOG4105KJM monovalent cation h antiporter subunit g EI070_17160 ENOG4105CHV Transcription elongation factor NusA EI070_17185 ENOG4107EJC Preprotein translocase subunit SecG EI070_17195 ENOG4107QHF type ii secretion system protein e EI070_17210 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EI070_17220 ENOG4105C2N RNA methyltransferase TrmH family group 3 EI070_17235 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EI070_17245 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EI070_17275 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EI070_17280 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EI070_17350 ENOG4107ZXU DSBA oxidoreductase EI070_17365 ENOG4108HWY Beta-lactamase EI070_17380 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EI070_17395 ENOG4105D3Y Na H antiporter EI070_17400 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EI070_17450 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EI070_17455 ENOG4105PM1 preprotein translocase subunit SecE EI070_17495 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EI070_17500 ENOG4105TV9 FHA Domain-Containing protein EI070_17505 ENOG4105GVR general secretion pathway protein D EI070_17520 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS EI070_17545 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EI070_17550 ENOG4108NEV two component transcriptional regulator, LytTR family EI070_17555 ENOG4108HRK Histidine kinase EI070_17570 ENOG4108UTW Plays a role in the regulation of phosphate uptake EI070_17575 ENOG4105DFG type I secretion outer membrane protein EI070_17580 ENOG4108RNG Permease of the drug metabolite transporter EI070_17605 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EI070_17610 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters EI070_17615 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) EI070_17620 ENOG4105CNI cell division protein FtsW EI070_17635 ENOG4105CE1 Ferrous iron transport protein b EI070_17645 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EI070_17650 ENOG4105T95 Thiol disulfide interChange protein EI070_17655 ENOG4105D6E homoserine dehydrogenase EI070_17665 ENOG41061WM D-Alanyl-D-Alanine EI070_17675 ENOG4107TUY Histidine kinase EI070_17680 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EI070_17685 ENOG4105CN1 protease EI070_17690 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EI070_17695 ENOG4108K5H permease YjgP YjgQ family protein EI070_17735 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EI070_17745 ENOG4105BZU Histidine kinase EI070_17760 ENOG4105C0P Mg chelatase subunit ChlI EI070_17770 ENOG4108R0M Aminoglycoside EI070_17815 ENOG4105CHH sulfate transporter EI070_17865 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EI070_17925 ENOG4108HWY Beta-lactamase EI070_17965 ENOG4105CHH sulfate transporter EI070_18010 ENOG4105C0P Mg chelatase subunit ChlI EI070_18015 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EI070_18025 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EI070_18035 ENOG4105EPF Outer membrane porin EI070_18040 ENOG4105F0N pyrophosphate phospho-hydrolase EI070_18055 ENOG4105CEY Amp-dependent synthetase and ligase EI070_18060 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EI070_18065 ENOG41079KZ Major Facilitator Superfamily EI070_18070 ENOG4105EN6 Membrane EI070_18080 ENOG4105EE5 Membrane protein terC EI070_18085 ENOG4108URH decarboxylase EI070_18100 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EI070_18115 ENOG4105CCT upf0313 protein EI070_18135 ENOG4105CS1 NAD(P)H quinone oxidoreductase EI070_18145 ENOG4105C6T cysteine synthase EI070_18180 ENOG4105Y7M Transcriptional regulator, TetR family EI070_18215 ENOG4105C79 DNA protecting protein DprA EI070_18230 ENOG4108IND Tetr family transcriptional regulator EI070_18235 ENOG4107RTG Major Facilitator superfamily EI070_18245 ENOG4108V06 Glutathione peroxidase EI070_18285 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EI070_18310 ENOG4105FDK ABC transporter EI070_18315 ENOG4105FAV ABC, transporter EI070_18325 ENOG4105EZR dyp-type peroxidase family protein EI070_18335 ENOG4107R1I NAD-dependent malic enzyme EI070_18360 ENOG4105EUB pirin domain protein EI070_18380 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EI070_18385 ENOG4106MP8 UPF0754 membrane protein EI070_18390 ENOG4108VBZ doxx family EI070_18395 ENOG4105DQR SNARE associated Golgi EI070_18410 ENOG4107QJE Chromosome Partitioning Protein EI070_18420 ENOG4107PSF BolA-like protein EI070_18440 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EI070_18465 ENOG4105C1G acyl-Coa dehydrogenase EI070_18490 ENOG4105CSH Transporter EI070_18495 ENOG4105E39 Enoyl-CoA hydratase EI070_18500 ENOG4105E39 Enoyl-CoA hydratase EI070_18505 ENOG4105C1G acyl-Coa dehydrogenase EI070_18515 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EI070_18520 ENOG4105C26 Dehydrogenase EI070_18530 ENOG4105C85 amino acid EI070_18535 ENOG4105C85 amino acid EI070_18540 ENOG4105M4H endoribonuclease L-psp EI070_18555 ENOG4105EW9 transcriptional regulator AsnC family EI070_18580 ENOG4105D3G Pseudouridine synthase EI070_18595 ENOG4108IG5 Transcriptional regulator EI070_18645 ENOG4108I0Z Aconitate hydratase EI070_18650 ENOG4105BZN citrate synthase EI070_18655 ENOG4105CR4 methylisocitrate lyase EI070_18660 ENOG4105DRR Transcriptional regulator, GntR family EI070_18670 ENOG4105CGF Aromatic amino acid aminotransferase EI070_18675 ENOG4105CXG d-lactate dehydrogenase EI070_18685 ENOG41073TP transcriptional regulator EI070_18690 ENOG4105DAA L-lactate EI070_18695 ENOG4107QKV phosphomannomutase EI070_18700 ENOG4105CMR udp-glucose 4-epimerase EI070_18710 ENOG4105C6Y Udp-glucose 6-dehydrogenase EI070_18715 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EI070_18720 ENOG4105D3Q Sugar transferase EI070_18725 ENOG4108RYC glycosyltransferase EI070_18770 ENOG4105F0R Cytidylyltransferase EI070_18775 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EI070_18780 ENOG4105C5E polysaccharide biosynthesis protein EI070_18785 ENOG4107QQG Dehydrogenase EI070_18795 ENOG4105DAY polysaccharide export protein EI070_18805 ENOG4105D75 Capsular exopolysaccharide family EI070_18810 ENOG4108V1T peptidylprolyl cis-trans isomerase EI070_18815 ENOG4108V1T peptidylprolyl cis-trans isomerase EI070_18820 ENOG4105CJR Integral membrane protein (MviN EI070_18825 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EI070_18830 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EI070_18865 ENOG41062JF Transcriptional regulator EI070_18880 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EI070_18885 ENOG4105UBK short-chain dehydrogenase reductase EI070_18900 ENOG4107QZM n-acetylglutamate synthase EI070_18905 ENOG4105GVF (ABC) transporter EI070_18910 ENOG4105GVF (ABC) transporter EI070_18915 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EI070_18920 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EI070_18925 ENOG4108VM9 ABC, transporter EI070_18930 ENOG4108R86 Transcriptional regulator EI070_18935 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EI070_18945 ENOG4105DTN riboflavin biosynthesis protein ribF EI070_18950 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EI070_18960 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase EI070_19000 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) EI070_19055 ENOG4105CVE Lytic murein transglycosylase EI070_19060 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EI070_19065 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EI070_19080 ENOG4105DFU Cell wall formation (By similarity) EI070_19090 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EI070_19095 ENOG4105DU1 integral membrane protein, terc EI070_19105 ENOG4106032 Glutathionylspermidine synthase EI070_19115 ENOG4107QUY Guanine deaminase EI070_19120 ENOG4108UGV hypoxanthine phosphoribosyltransferase EI070_19130 ENOG4105T95 Thiol disulfide interChange protein EI070_19135 ENOG4105PGM cation diffusion facilitator family transporter EI070_19150 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EI070_19165 ENOG4105VG0 50S ribosomal protein l34