locus-tag	class	description
H2784_00010	COG0592	DNA-directed DNA polymerase activity
H2784_00020	COG0187	DNA topoisomerase II activity
H2784_00030	COG0586	Pfam SNARE associated Golgi protein
H2784_00035	COG0488	(ABC) transporter
H2784_00060	COG0596	Alpha beta hydrolase
H2784_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H2784_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H2784_00115	COG0733	neurotransmitter:sodium symporter activity
H2784_00125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H2784_00150	COG0583	DNA-binding transcription factor activity
H2784_00155	COG2233	PERMEase
H2784_00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2784_00205	COG2814	Major facilitator Superfamily
H2784_00210	COG0656	L-ascorbic acid biosynthetic process
H2784_00215	COG0583	DNA-binding transcription factor activity
H2784_00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2784_00235	COG1064	alcohol dehydrogenase
H2784_00240	COG2818	Glycosylase
H2784_00255	COG1194	a g-specific adenine glycosylase
H2784_00275	COG2983	Belongs to the UPF0260 family
H2784_00280	COG2133	pyrroloquinoline quinone binding
H2784_00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H2784_00290	COG2116	formate transmembrane transporter activity
H2784_00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2784_00315	COG1335	isochorismatase
H2784_00320	COG0385	Bile acid
H2784_00325	COG0534	Mate efflux family protein
H2784_00330	COG1683	Conserved Protein
H2784_00350	COG0625	glutathione transferase activity
H2784_00360	COG1113	amino acid transport
H2784_00370	COG0523	cobalamin synthesis protein
H2784_00380	COG2188	Transcriptional regulator
H2784_00410	COG0010	Belongs to the arginase family
H2784_00425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H2784_00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H2784_00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H2784_00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H2784_00530	COG0534	Mate efflux family protein
H2784_00535	COG0436	Aminotransferase
H2784_00540	COG2733	membrane
H2784_00555	COG2918	glutathione biosynthetic process
H2784_00570	COG3179	chitinase
H2784_00585	COG3150	esterase
H2784_00595	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H2784_00605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2784_00615	COG2233	PERMEase
H2784_00620	COG2351	hydroxyisourate hydrolase activity
H2784_00655	COG3706	GGDEF domain
H2784_00670	COG1393	Belongs to the ArsC family
H2784_00675	COG0708	Exodeoxyribonuclease III
H2784_00695	COG0189	ligase activity
H2784_00715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H2784_00725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H2784_00740	COG4942	peptidase
H2784_00750	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2784_00760	COG2119	membrane
H2784_00765	COG4774	siderophore transport
H2784_00770	COG0426	domain, Protein
H2784_00770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2784_00795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H2784_00820	COG1902	pentaerythritol trinitrate reductase activity
H2784_00825	COG1519	Transferase
H2784_00830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2784_00835	COG0668	transmembrane transport
H2784_00845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2784_00850	COG1335	isochorismatase
H2784_00855	COG1522	sequence-specific DNA binding
H2784_00880	COG0784	Response regulator, receiver
H2784_00880	COG2205	protein histidine kinase activity
H2784_00880	COG2198	Histidine kinase
H2784_00885	COG3162	membrane
H2784_00890	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2784_00900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2784_00915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H2784_00920	COG1309	transcriptional regulator
H2784_00940	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H2784_00940	COG0352	thiamine-phosphate diphosphorylase activity
H2784_00940	COG0351	phosphomethylpyrimidine kinase
H2784_00950	COG2814	Major facilitator Superfamily
H2784_00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H2784_01000	COG1113	amino acid transport
H2784_01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2784_01015	COG1012	belongs to the aldehyde dehydrogenase family
H2784_01025	COG1335	isochorismatase
H2784_01055	COG2814	Major facilitator Superfamily
H2784_01060	COG0583	DNA-binding transcription factor activity
H2784_01080	COG0667	Aldo Keto reductase
H2784_01095	COG3081	Nucleoid-associated protein
H2784_01110	COG1733	regulation of RNA biosynthetic process
H2784_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2784_01185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H2784_01210	COG1132	(ABC) transporter
H2784_01230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H2784_01260	COG0427	acetyl-CoA hydrolase
H2784_01285	COG0659	secondary active sulfate transmembrane transporter activity
H2784_01290	COG4221	oxidoreductase activity
H2784_01300	COG0488	(ABC) transporter
H2784_01365	COG0833	amino acid
H2784_01410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H2784_01415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H2784_01430	COG2226	methyltransferase
H2784_01480	COG0067	glutamate synthase
H2784_01480	COG0070	glutamate synthase
H2784_01480	COG0069	glutamate synthase activity
H2784_01485	COG0493	'glutamate synthase
H2784_01495	COG1704	LemA family
H2784_01500	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H2784_01520	COG3307	-O-antigen
H2784_01540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2784_01555	COG0194	GDP metabolic process
H2784_01605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H2784_01625	COG5380	lipid catabolic process
H2784_01630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H2784_01655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H2784_01660	COG0277	FAD linked oxidase domain protein
H2784_01670	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H2784_01675	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2784_01690	COG1289	transmembrane transporter activity
H2784_01700	COG0628	permease
H2784_01705	COG1192	Involved in chromosome partitioning
H2784_01735	COG0833	amino acid
H2784_01755	COG1012	belongs to the aldehyde dehydrogenase family
H2784_01795	COG0583	DNA-binding transcription factor activity
H2784_01845	COG0517	IMP dehydrogenase activity
H2784_01850	COG1983	PspC domain protein
H2784_01860	COG1960	acyl-CoA dehydrogenase activity
H2784_01875	COG0408	coproporphyrinogen oxidase activity
H2784_01895	COG0513	Belongs to the DEAD box helicase family
H2784_01905	COG1127	ABC transporter
H2784_01910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H2784_01920	COG2854	intermembrane phospholipid transfer
H2784_01930	COG0598	Magnesium transport protein CorA
H2784_01940	COG0494	nUDIX hydrolase
H2784_01945	COG1040	competence protein
H2784_01950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H2784_01965	COG2937	Belongs to the GPAT DAPAT family
H2784_01970	COG1946	Acyl-CoA thioesterase
H2784_01975	COG1301	dicarboxylic acid transport
H2784_01990	COG1959	2 iron, 2 sulfur cluster binding
H2784_01995	COG1017	nitric oxide dioxygenase activity
H2784_01995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2784_02005	COG0433	COG0433 Predicted ATPase
H2784_02010	COG0626	cystathionine gamma-synthase activity
H2784_02165	COG1960	acyl-CoA dehydrogenase activity
H2784_02170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H2784_02200	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H2784_02205	COG0339	signal peptide processing
H2784_02210	COG0557	exoribonuclease II activity
H2784_02255	COG0179	Fumarylacetoacetate (FAA) hydrolase
H2784_02260	COG2169	Transcriptional regulator
H2784_02265	COG0697	spore germination
H2784_02270	COG1295	ribonuclease BN
H2784_02305	COG1702	phosphate starvation-inducible protein PhoH
H2784_02315	COG0741	lytic transglycosylase activity
H2784_02315	COG1196	nuclear chromosome segregation
H2784_02315	COG0739	heme binding
H2784_02345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H2784_02350	COG1183	phosphatidylcholine synthase activity
H2784_02395	COG1960	acyl-CoA dehydrogenase activity
H2784_02400	COG1309	transcriptional regulator
H2784_02415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2784_02420	COG1960	acyl-CoA dehydrogenase activity
H2784_02440	COG2969	positive regulation of protein catabolic process
H2784_02450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H2784_02460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H2784_02465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H2784_02470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H2784_02490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H2784_02500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2784_02505	COG1408	metallophosphoesterase
H2784_02515	COG2199	diguanylate cyclase activity
H2784_02575	COG1607	acyl-coa hydrolase
H2784_02605	COG2350	Protein conserved in bacteria
H2784_02615	COG0613	PHP domain protein
H2784_02620	COG3781	membrane
H2784_02630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H2784_02635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H2784_02645	COG1862	Preprotein translocase
H2784_02675	COG2205	protein histidine kinase activity
H2784_02680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H2784_02700	COG0726	polysaccharide deacetylase
H2784_02705	COG0463	Glycosyl transferase, family 2
H2784_02710	COG0438	transferase activity, transferring glycosyl groups
H2784_02775	COG1960	acyl-CoA dehydrogenase activity
H2784_02780	COG1960	acyl-CoA dehydrogenase activity
H2784_02790	COG2205	protein histidine kinase activity
H2784_02795	COG0745	RESPONSE REGULATOR receiver
H2784_02800	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H2784_02820	COG2096	Adenosyltransferase
H2784_02870	COG0285	dihydrofolate synthase activity
H2784_02890	COG0450	alkyl hydroperoxide reductase
H2784_02905	COG0477	Major facilitator Superfamily
H2784_02910	COG1272	protein, Hemolysin III
H2784_02920	COG2153	protein acetylation
H2784_02940	COG0183	Belongs to the thiolase family
H2784_02945	COG2207	Transcriptional regulator
H2784_02965	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2784_02985	COG0183	Belongs to the thiolase family
H2784_02995	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H2784_02995	COG2885	chlorophyll binding
H2784_03005	COG1690	Belongs to the RtcB family
H2784_03010	COG0833	amino acid
H2784_03020	COG2233	PERMEase
H2784_03025	COG1217	gtp-binding protein TYPA
H2784_03050	COG2094	Belongs to the DNA glycosylase MPG family
H2784_03055	COG4772	TonB-dependent receptor
H2784_03060	COG1902	pentaerythritol trinitrate reductase activity
H2784_03075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2784_03080	COG0354	folic acid binding
H2784_03090	COG3189	MarR family transcriptional regulator
H2784_03095	COG2824	Alkylphosphonate utilization operon protein PhnA
H2784_03100	COG3422	double-strand break repair
H2784_03140	COG0840	transmembrane signaling receptor activity
H2784_03160	COG5510	response to toxic substance
H2784_03170	COG2832	Protein of unknown function (DUF454)
H2784_03175	COG1376	ErfK ybiS ycfS ynhG family protein
H2784_03215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H2784_03225	COG1289	transmembrane transporter activity
H2784_03230	COG2814	Major facilitator Superfamily
H2784_03250	COG1115	amino acid carrier protein
H2784_03255	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2784_03260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2784_03265	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H2784_03290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2784_03300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H2784_03305	COG1077	Cell shape determining protein MreB Mrl
H2784_03310	COG1792	Involved in formation and maintenance of cell shape
H2784_03315	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H2784_03320	COG0424	maF-like protein
H2784_03325	COG1530	ribonuclease E activity
H2784_03335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2784_03345	COG0560	Phosphoserine phosphatase
H2784_03355	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2784_03380	COG2207	Transcriptional regulator
H2784_03425	COG1113	amino acid transport
H2784_03430	COG2828	Protein conserved in bacteria
H2784_03435	COG0142	geranyltranstransferase activity
H2784_03440	COG2315	Protein conserved in bacteria
H2784_03455	COG1752	Esterase of the alpha-beta hydrolase superfamily
H2784_03475	COG2194	sulfuric ester hydrolase activity
H2784_03480	COG0745	RESPONSE REGULATOR receiver
H2784_03485	COG0642	Histidine kinase
H2784_03495	COG0004	ammonium transporteR
H2784_03500	COG0583	DNA-binding transcription factor activity
H2784_03520	COG0525	valine-tRNA ligase activity
H2784_03530	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_03540	COG0393	Putative heavy-metal-binding
H2784_03545	COG0393	Putative heavy-metal-binding
H2784_03550	COG1538	Outer membrane efflux protein
H2784_03560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2784_03565	COG0671	phosphoesterase, PA-phosphatase related
H2784_03595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H2784_03610	COG1648	precorrin-2 dehydrogenase activity
H2784_03610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H2784_03615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H2784_03630	COG0531	amino acid
H2784_03645	COG0321	lipoyl(octanoyl) transferase activity
H2784_03650	COG2921	Belongs to the UPF0250 family
H2784_03690	COG2009	succinate dehydrogenase
H2784_03695	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H2784_03700	COG1053	succinate dehydrogenase
H2784_03705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H2784_03730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2784_03750	COG2354	Protein conserved in bacteria
H2784_03755	COG2321	neutral zinc metallopeptidase
H2784_03775	COG2843	Capsule synthesis protein
H2784_03790	COG0589	response to stress
H2784_03810	COG0505	Belongs to the CarA family
H2784_03835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2784_03840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H2784_03890	COG0477	Major facilitator Superfamily
H2784_03895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H2784_03910	COG1597	lipid kinase activity
H2784_03915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H2784_03940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2784_03945	COG0584	glycerophosphoryl diester phosphodiesterase
H2784_03965	COG0741	lytic transglycosylase activity
H2784_03985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H2784_04000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2784_04010	COG3811	Belongs to the UPF0386 family
H2784_04050	COG0778	Nitroreductase
H2784_04065	COG1929	Belongs to the glycerate kinase type-1 family
H2784_04070	COG0243	molybdopterin cofactor binding
H2784_04075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H2784_04080	COG3339	Conserved Protein
H2784_04090	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H2784_04105	COG1113	amino acid transport
H2784_04115	COG0019	diaminopimelate decarboxylase activity
H2784_04125	COG1280	lysine exporter protein (LysE YggA)
H2784_04130	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H2784_04160	COG0463	Glycosyl transferase, family 2
H2784_04180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2784_04215	COG4591	ABC-type transport system involved in lipoprotein release permease component
H2784_04220	COG1136	(ABC) transporter
H2784_04225	COG0658	competence protein
H2784_04225	COG2333	competence protein COMEC
H2784_04235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H2784_04235	COG0616	signal peptide processing
H2784_04240	COG0596	Alpha beta hydrolase
H2784_04245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H2784_04255	COG0628	permease
H2784_04290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2784_04310	COG0823	Involved in the tonB-independent uptake of proteins
H2784_04330	COG0824	Thioesterase
H2784_04335	COG1473	amidohydrolase
H2784_04355	COG0047	phosphoribosylformylglycinamidine synthase activity
H2784_04355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H2784_04360	COG2814	Major facilitator Superfamily
H2784_04370	COG1024	Enoyl-CoA hydratase
H2784_04375	COG1051	belongs to the nudix hydrolase family
H2784_04375	COG1056	cytidyltransferase-related domain
H2784_04385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H2784_04400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H2784_04415	COG4625	pathogenesis
H2784_04420	COG0583	DNA-binding transcription factor activity
H2784_04425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H2784_04430	COG4208	sulfate ABC transporter
H2784_04435	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H2784_04445	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H2784_04450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2784_04455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H2784_04475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2784_04490	COG0681	Belongs to the peptidase S26 family
H2784_04505	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H2784_04515	COG1381	Involved in DNA repair and RecF pathway recombination
H2784_04520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H2784_04530	COG4221	oxidoreductase activity
H2784_04560	COG0443	Heat shock 70 kDa protein
H2784_04570	COG0436	Aminotransferase
H2784_04590	COG0556	nucleotide-excision repair
H2784_04645	COG2070	2-Nitropropane dioxygenase
H2784_04675	COG1215	transferase activity, transferring glycosyl groups
H2784_04690	COG0415	Belongs to the DNA photolyase family
H2784_04700	COG1252	NADH dehydrogenase
H2784_04705	COG1686	Belongs to the peptidase S11 family
H2784_04720	COG1187	pseudouridine synthase activity
H2784_04745	COG0477	Major facilitator Superfamily
H2784_04750	COG0583	DNA-binding transcription factor activity
H2784_04755	COG1823	symporter activity
H2784_04765	COG0612	Peptidase, M16
H2784_04790	COG0352	thiamine-phosphate diphosphorylase activity
H2784_04825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2784_04840	COG1309	transcriptional regulator
H2784_04850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H2784_04855	COG0076	glutamate decarboxylase activity
H2784_04865	COG1522	sequence-specific DNA binding
H2784_04870	COG3961	Belongs to the TPP enzyme family
H2784_04875	COG1113	amino acid transport
H2784_04880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H2784_04885	COG0573	inorganic phosphate transmembrane transporter activity
H2784_04895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H2784_04900	COG0616	signal peptide processing
H2784_04935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H2784_04940	COG1686	Belongs to the peptidase S11 family
H2784_04965	COG0583	DNA-binding transcription factor activity
H2784_04970	COG1067	ATP-dependent peptidase activity
H2784_04995	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H2784_05015	COG1966	Carbon starvation protein
H2784_05020	COG2879	small protein
H2784_05060	COG1335	isochorismatase
H2784_05065	COG0583	DNA-binding transcription factor activity
H2784_05080	COG0596	Alpha beta hydrolase
H2784_05090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2784_05105	COG3659	wide pore channel activity
H2784_05130	COG0583	DNA-binding transcription factor activity
H2784_05135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H2784_05140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2784_05145	COG2828	Protein conserved in bacteria
H2784_05170	COG1741	Belongs to the pirin family
H2784_05180	COG2964	Protein conserved in bacteria
H2784_05195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2784_05200	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2784_05205	COG4605	iron ion homeostasis
H2784_05210	COG4604	ABC transporter, ATP-binding protein
H2784_05215	COG4607	ABC-type enterochelin transport system periplasmic component
H2784_05220	COG4774	siderophore transport
H2784_05230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H2784_05235	COG1021	2,3-dihydroxybenzoate-AMP ligase
H2784_05240	COG3433	isochorismatase activity
H2784_05240	COG1535	isochorismatase
H2784_05250	COG1132	(ABC) transporter
H2784_05255	COG1132	(ABC) transporter
H2784_05260	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H2784_05285	COG3739	integral membrane protein
H2784_05305	COG0302	gtp cyclohydrolase
H2784_05315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H2784_05345	COG0308	aminopeptidase N
H2784_05350	COG0512	Glutamine amidotransferase of anthranilate synthase
H2784_05365	COG0174	glutamine synthetase
H2784_05375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H2784_05410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H2784_05415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H2784_05420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H2784_05440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H2784_05445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H2784_05450	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H2784_05465	COG1960	acyl-CoA dehydrogenase activity
H2784_05470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H2784_05475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2784_05485	COG2223	nitrite transmembrane transporter activity
H2784_05495	COG0024	Methionine aminopeptidase
H2784_05500	COG0052	Belongs to the universal ribosomal protein uS2 family
H2784_05515	COG2207	Transcriptional regulator
H2784_05540	COG2951	lytic endotransglycosylase activity
H2784_05545	COG0772	Belongs to the SEDS family
H2784_05560	COG0842	Transport permease protein
H2784_05565	COG1131	(ABC) transporter
H2784_05610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2784_05625	COG4215	(ABC) transporter
H2784_05630	COG4160	amino acid transport
H2784_05635	COG4598	ABC transporter
H2784_05645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2784_05650	COG0826	peptidase U32
H2784_05655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2784_05670	COG1720	tRNA m6t6A37 methyltransferase activity
H2784_05680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H2784_05695	COG0642	Histidine kinase
H2784_05705	COG0494	nUDIX hydrolase
H2784_05715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H2784_05720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H2784_05725	COG3139	Protein of unknown function (DUF1315)
H2784_05735	COG1301	dicarboxylic acid transport
H2784_05740	COG1960	acyl-CoA dehydrogenase activity
H2784_05745	COG2819	hydrolase of the alpha beta superfamily
H2784_05755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H2784_05765	COG2195	Cleaves the N-terminal amino acid of tripeptides
H2784_05770	COG1234	tRNA 3'-trailer cleavage
H2784_05800	COG2363	Small membrane protein
H2784_05820	COG0513	Belongs to the DEAD box helicase family
H2784_05830	COG0778	Nitroreductase
H2784_05860	COG1286	toxin biosynthetic process
H2784_05885	COG4783	chaperone-mediated protein folding
H2784_05890	COG1610	YqeY-like protein
H2784_05920	COG2815	serine threonine protein kinase
H2784_05920	COG0515	serine threonine protein kinase
H2784_05945	COG2831	hemolysin activation secretion protein
H2784_06030	COG3111	PFAM Bacterial OB fold (BOF) protein
H2784_06055	COG3243	poly(R)-hydroxyalkanoic acid synthase
H2784_06060	COG0786	glutamate:sodium symporter activity
H2784_06070	COG2186	Transcriptional regulator
H2784_06120	COG0477	Major facilitator Superfamily
H2784_06145	COG2995	paraquat-inducible protein a
H2784_06150	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H2784_06150	COG3008	intermembrane lipid transfer
H2784_06160	COG1794	racemase activity, acting on amino acids and derivatives
H2784_06190	COG1301	dicarboxylic acid transport
H2784_06200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2784_06205	COG2011	ABC-type metal ion transport system permease component
H2784_06210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2784_06215	COG1464	Belongs to the NlpA lipoprotein family
H2784_06220	COG0151	Belongs to the GarS family
H2784_06225	COG0138	bifunctional purine biosynthesis protein purh
H2784_06230	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H2784_06260	COG2308	Evidence 4 Homologs of previously reported genes of
H2784_06270	COG1305	Transglutaminase-like
H2784_06280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H2784_06285	COG0305	Participates in initiation and elongation during chromosome replication
H2784_06310	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H2784_06320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H2784_06325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H2784_06350	COG0726	polysaccharide deacetylase
H2784_06350	COG1649	PFAM Uncharacterised BCR, COG1649
H2784_06355	COG1215	transferase activity, transferring glycosyl groups
H2784_06360	COG3658	cytochrome
H2784_06370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2784_06385	COG0583	DNA-binding transcription factor activity
H2784_06415	COG1960	acyl-CoA dehydrogenase activity
H2784_06420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2784_06425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2784_06450	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H2784_06455	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H2784_06465	COG2205	protein histidine kinase activity
H2784_06470	COG0745	RESPONSE REGULATOR receiver
H2784_06475	COG0174	glutamine synthetase
H2784_06495	COG0729	surface antigen
H2784_06520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2784_06525	COG2814	Major facilitator Superfamily
H2784_06540	COG0583	DNA-binding transcription factor activity
H2784_06555	COG1187	pseudouridine synthase activity
H2784_06575	COG0802	atpase or kinase
H2784_06580	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H2784_06590	COG1923	regulation of RNA biosynthetic process
H2784_06595	COG0697	spore germination
H2784_06610	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2784_06620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2784_06625	COG0519	Catalyzes the synthesis of GMP from XMP
H2784_06625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2784_06630	COG4302	ethanolamine ammonia-lyase activity
H2784_06635	COG4303	Ethanolamine ammonia lyase large subunit
H2784_06640	COG0531	amino acid
H2784_06660	COG1454	alcohol dehydrogenase
H2784_06665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2784_06675	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H2784_06695	COG0308	aminopeptidase N
H2784_06735	COG1605	Chorismate mutase
H2784_06750	COG1309	transcriptional regulator
H2784_06760	COG0668	transmembrane transport
H2784_06790	COG4773	Receptor
H2784_06810	COG0488	(ABC) transporter
H2784_06815	COG0589	response to stress
H2784_06840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H2784_06850	COG3135	benzoate transporter
H2784_06855	COG1522	sequence-specific DNA binding
H2784_06865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H2784_06870	COG0583	DNA-binding transcription factor activity
H2784_06880	COG0183	Belongs to the thiolase family
H2784_06890	COG2030	dehydratase
H2784_06895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2784_06910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H2784_06925	COG0824	Thioesterase
H2784_06930	COG1454	alcohol dehydrogenase
H2784_06940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H2784_06960	COG0069	glutamate synthase activity
H2784_06980	COG2814	Major facilitator Superfamily
H2784_06995	COG0511	ligase activity, forming carbon-carbon bonds
H2784_07015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2784_07015	COG1116	anion transmembrane transporter activity
H2784_07020	COG0745	RESPONSE REGULATOR receiver
H2784_07030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2784_07030	COG2146	nitrite reductase [NAD(P)H] activity
H2784_07035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2784_07040	COG0243	molybdopterin cofactor binding
H2784_07050	COG0243	molybdopterin cofactor binding
H2784_07055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H2784_07070	COG0521	Mo-molybdopterin cofactor biosynthetic process
H2784_07070	COG0315	cyclic pyranopterin monophosphate synthase activity
H2784_07075	COG0303	'Molybdopterin
H2784_07085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2784_07090	COG0697	spore germination
H2784_07110	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H2784_07115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H2784_07170	COG2204	response regulator
H2784_07175	COG3852	Histidine kinase
H2784_07195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H2784_07200	COG0575	Belongs to the CDS family
H2784_07235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2784_07250	COG2137	regulation of response to DNA damage stimulus
H2784_07260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H2784_07265	COG1011	Hydrolase
H2784_07290	COG1522	sequence-specific DNA binding
H2784_07300	COG1113	amino acid transport
H2784_07315	COG0659	secondary active sulfate transmembrane transporter activity
H2784_07320	COG2135	peptidase activity
H2784_07335	COG5001	Diguanylate cyclase
H2784_07335	COG3300	MHYT domain
H2784_07350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2784_07350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H2784_07350	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H2784_07355	COG1105	Belongs to the carbohydrate kinase PfkB family
H2784_07360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H2784_07360	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2784_07390	COG0024	Methionine aminopeptidase
H2784_07395	COG0583	DNA-binding transcription factor activity
H2784_07405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H2784_07410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H2784_07415	COG0516	GMP reductase activity
H2784_07415	COG0517	IMP dehydrogenase activity
H2784_07440	COG0552	protein localization to endoplasmic reticulum
H2784_07450	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H2784_07460	COG4890	Cyd operon protein YbgT
H2784_07465	COG1294	oxidase, subunit
H2784_07480	COG1585	Membrane protein implicated in regulation of membrane protease activity
H2784_07490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H2784_07495	COG4774	siderophore transport
H2784_07510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H2784_07515	COG0569	domain protein
H2784_07520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H2784_07550	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H2784_07555	COG0542	response to heat
H2784_07580	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2784_07580	COG1902	pentaerythritol trinitrate reductase activity
H2784_07625	COG2323	membrane
H2784_07630	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H2784_07640	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2784_07645	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2784_07650	COG0183	Belongs to the thiolase family
H2784_07655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H2784_07660	COG0596	Alpha beta hydrolase
H2784_07665	COG2271	Major facilitator Superfamily
H2784_07670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H2784_07675	COG3485	protocatechuate 3,4-dioxygenase
H2784_07680	COG3485	protocatechuate 3,4-dioxygenase
H2784_07685	COG0710	3-dehydroquinate dehydratase activity
H2784_07690	COG3420	alginic acid biosynthetic process
H2784_07695	COG3659	wide pore channel activity
H2784_07700	COG4993	Dehydrogenase
H2784_07710	COG2391	methyltransferase activity
H2784_07725	COG1414	Transcriptional regulator
H2784_07730	COG0583	DNA-binding transcription factor activity
H2784_07735	COG1960	acyl-CoA dehydrogenase activity
H2784_07760	COG2814	Major facilitator Superfamily
H2784_07770	COG0154	amidase activity
H2784_07790	COG4638	Rieske (2fe-2S)
H2784_07800	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_07810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2784_07820	COG3733	amine oxidase
H2784_07830	COG1012	belongs to the aldehyde dehydrogenase family
H2784_07840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2784_07845	COG0183	Belongs to the thiolase family
H2784_07850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2784_07855	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2784_07865	COG4829	muconolactone delta-isomerase
H2784_07870	COG4948	Mandelate Racemase Muconate Lactonizing
H2784_07875	COG0583	DNA-binding transcription factor activity
H2784_07885	COG2186	Transcriptional regulator
H2784_07905	COG1012	belongs to the aldehyde dehydrogenase family
H2784_07920	COG1902	pentaerythritol trinitrate reductase activity
H2784_07920	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2784_07960	COG1309	transcriptional regulator
H2784_07970	COG1335	isochorismatase
H2784_07975	COG0583	DNA-binding transcription factor activity
H2784_07985	COG0475	glutathione-regulated potassium exporter activity
H2784_07985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2784_08035	COG2188	Transcriptional regulator
H2784_08050	COG0583	DNA-binding transcription factor activity
H2784_08075	COG1566	PFAM secretion protein HlyD family protein
H2784_08090	COG1012	belongs to the aldehyde dehydrogenase family
H2784_08095	COG0129	dihydroxy-acid dehydratase activity
H2784_08105	COG0583	DNA-binding transcription factor activity
H2784_08110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H2784_08120	COG2084	Dehydrogenase
H2784_08125	COG2207	Transcriptional regulator
H2784_08140	COG1064	alcohol dehydrogenase
H2784_08150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H2784_08155	COG1120	ATPase activity
H2784_08175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2784_08225	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H2784_08295	COG1073	alpha beta
H2784_08305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2784_08335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2784_08340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2784_08345	COG0745	RESPONSE REGULATOR receiver
H2784_08350	COG2205	protein histidine kinase activity
H2784_08380	COG2072	flavoprotein involved in K transport
H2784_08385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H2784_08415	COG1946	Acyl-CoA thioesterase
H2784_08420	COG0318	PFAM AMP-dependent synthetase and ligase
H2784_08425	COG0583	DNA-binding transcription factor activity
H2784_08445	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_08450	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_08460	COG1960	acyl-CoA dehydrogenase activity
H2784_08465	COG0183	Belongs to the thiolase family
H2784_08475	COG2271	Major facilitator Superfamily
H2784_08480	COG0251	oxidation-reduction process
H2784_08490	COG1960	acyl-CoA dehydrogenase activity
H2784_08495	COG3231	kanamycin kinase activity
H2784_08510	COG1960	acyl-CoA dehydrogenase activity
H2784_08515	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_08520	COG3829	transcription factor binding
H2784_08630	COG3539	Fimbrial protein
H2784_08655	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H2784_08665	COG0753	catalase activity
H2784_08680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H2784_08745	COG1535	isochorismatase
H2784_08745	COG3433	isochorismatase activity
H2784_08750	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_08755	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H2784_08760	COG4149	molybdate abc transporter
H2784_08765	COG0725	ABC transporter, periplasmic molybdate-binding protein
H2784_08775	COG4638	Rieske (2fe-2S)
H2784_08780	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H2784_08785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2784_08785	COG0543	2 iron, 2 sulfur cluster binding
H2784_08800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2784_08810	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_08825	COG2207	Transcriptional regulator
H2784_08830	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_08835	COG2610	gluconate transmembrane transporter activity
H2784_08845	COG1309	transcriptional regulator
H2784_08865	COG0583	DNA-binding transcription factor activity
H2784_08880	COG2031	fatty acid transporter
H2784_08885	COG0183	Belongs to the thiolase family
H2784_08890	COG0583	DNA-binding transcription factor activity
H2784_08895	COG0583	DNA-binding transcription factor activity
H2784_08910	COG1027	Aspartate ammonia-lyase
H2784_08920	COG0477	Major facilitator Superfamily
H2784_08945	COG4521	taurine ABC transporter
H2784_08960	COG2188	Transcriptional regulator
H2784_08970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H2784_08975	COG1733	regulation of RNA biosynthetic process
H2784_08980	COG2207	Transcriptional regulator
H2784_08980	COG3708	Transcriptional regulator
H2784_08995	COG0730	response to heat
H2784_09005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2784_09005	COG3453	Protein conserved in bacteria
H2784_09015	COG3781	membrane
H2784_09020	COG1063	alcohol dehydrogenase
H2784_09030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H2784_09035	COG0508	dehydrogenase complex catalyzes the overall conversion of
H2784_09040	COG0022	dehydrogenase e1 component
H2784_09045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H2784_09050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H2784_09065	COG3706	GGDEF domain
H2784_09080	COG0133	tryptophan synthase activity
H2784_09090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H2784_09125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H2784_09150	COG2226	methyltransferase
H2784_09205	COG0842	Transport permease protein
H2784_09210	COG0842	Transport permease protein
H2784_09215	COG1131	(ABC) transporter
H2784_09230	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H2784_09235	COG4773	Receptor
H2784_09255	COG0730	response to heat
H2784_09260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H2784_09280	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H2784_09295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2784_09325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2784_09335	COG4264	IucA IucC family
H2784_09340	COG4264	IucA IucC family
H2784_09345	COG2814	Major facilitator Superfamily
H2784_09360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H2784_09375	COG1960	acyl-CoA dehydrogenase activity
H2784_09380	COG1960	acyl-CoA dehydrogenase activity
H2784_09385	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H2784_09390	COG2207	Transcriptional regulator
H2784_09395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2784_09400	COG0776	regulation of translation
H2784_09425	COG0822	iron-sulfur transferase activity
H2784_09430	COG0316	Belongs to the HesB IscA family
H2784_09460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H2784_09480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H2784_09485	COG0702	epimerase
H2784_09520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H2784_09530	COG0339	signal peptide processing
H2784_09575	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H2784_09580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H2784_09610	COG0776	regulation of translation
H2784_09675	COG0084	hydrolase, TatD family'
H2784_09695	COG1663	tetraacyldisaccharide 4'-kinase activity
H2784_09700	COG1132	(ABC) transporter
H2784_09710	COG0811	peptide transport
H2784_09715	COG1475	DNA binding
H2784_09720	COG1192	Involved in chromosome partitioning
H2784_09730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H2784_09745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H2784_09750	COG0191	fructose-bisphosphate aldolase activity
H2784_09770	COG0424	maF-like protein
H2784_09775	COG2850	peptidyl-arginine hydroxylation
H2784_09785	COG0640	Transcriptional regulator
H2784_09795	COG3619	membrane
H2784_09800	COG3122	Protein conserved in bacteria
H2784_09805	COG1132	(ABC) transporter
H2784_09825	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H2784_09830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H2784_09840	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H2784_09840	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H2784_09840	COG0506	proline dehydrogenase activity
H2784_09845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H2784_09860	COG3698	Phosphodiester glycosidase
H2784_09870	COG2353	YceI-like domain
H2784_09880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H2784_09925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H2784_09925	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H2784_09950	COG3539	Fimbrial protein
H2784_09955	COG3121	Chaperone
H2784_09985	COG0697	spore germination
H2784_09995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H2784_10005	COG0583	DNA-binding transcription factor activity
H2784_10025	COG1309	transcriptional regulator
H2784_10040	COG1522	sequence-specific DNA binding
H2784_10050	COG1126	abc transporter atp-binding protein
H2784_10055	COG0765	amino acid transport
H2784_10060	COG0765	amino acid transport
H2784_10090	COG1464	Belongs to the NlpA lipoprotein family
H2784_10100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H2784_10105	COG2011	ABC-type metal ion transport system permease component
H2784_10110	COG0012	GTP binding
H2784_10135	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H2784_10175	COG0386	Belongs to the glutathione peroxidase family
H2784_10185	COG0436	Aminotransferase
H2784_10225	COG3634	alkyl hydroperoxide reductase activity
H2784_10240	COG0583	DNA-binding transcription factor activity
H2784_10245	COG0798	PFAM Bile acid sodium symporter
H2784_10250	COG0640	Transcriptional regulator
H2784_10265	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H2784_10275	COG0583	DNA-binding transcription factor activity
H2784_10285	COG1953	Uracil, thiamine, allantoin
H2784_10295	COG2175	clavaminate synthase activity
H2784_10300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2784_10305	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H2784_10310	COG4521	taurine ABC transporter
H2784_10320	COG0477	Major facilitator Superfamily
H2784_10340	COG1271	oxidase subunit
H2784_10345	COG1294	oxidase, subunit
H2784_10355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2784_10375	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H2784_10395	COG3052	prosthetic group binding
H2784_10400	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H2784_10410	COG0583	DNA-binding transcription factor activity
H2784_10420	COG2814	Major facilitator Superfamily
H2784_10440	COG1346	cytolysis
H2784_10450	COG0583	DNA-binding transcription factor activity
H2784_10455	COG0625	glutathione transferase activity
H2784_10460	COG0625	glutathione transferase activity
H2784_10465	COG0583	DNA-binding transcription factor activity
H2784_10480	COG1045	serine acetyltransferase
H2784_10485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H2784_10490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H2784_10495	COG1280	lysine exporter protein (LysE YggA)
H2784_10510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2784_10515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2784_10520	COG1126	abc transporter atp-binding protein
H2784_10525	COG0765	amino acid transport
H2784_10530	COG0765	amino acid transport
H2784_10550	COG2205	protein histidine kinase activity
H2784_10550	COG0784	Response regulator, receiver
H2784_10570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H2784_10590	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_10640	COG0583	DNA-binding transcription factor activity
H2784_10660	COG0318	PFAM AMP-dependent synthetase and ligase
H2784_10665	COG1309	transcriptional regulator
H2784_10670	COG1960	acyl-CoA dehydrogenase activity
H2784_10675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H2784_10680	COG1024	Enoyl-CoA hydratase
H2784_10685	COG4770	biotin carboxylase activity
H2784_10695	COG0583	DNA-binding transcription factor activity
H2784_10710	COG1960	acyl-CoA dehydrogenase activity
H2784_10720	COG2814	Major facilitator Superfamily
H2784_10730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H2784_10735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H2784_10740	COG2814	Major facilitator Superfamily
H2784_10745	COG1960	acyl-CoA dehydrogenase activity
H2784_10750	COG1024	Enoyl-CoA hydratase
H2784_10755	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_10760	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2784_10765	COG0183	Belongs to the thiolase family
H2784_10775	COG2814	Major facilitator Superfamily
H2784_10785	COG1024	Enoyl-CoA hydratase
H2784_10795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H2784_10800	COG1960	acyl-CoA dehydrogenase activity
H2784_10805	COG2814	Major facilitator Superfamily
H2784_10810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2784_10815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H2784_10815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H2784_10830	COG3842	ATPase activity
H2784_10835	COG1840	ABC-type Fe3 transport system, periplasmic component
H2784_10845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2784_10850	COG1414	Transcriptional regulator
H2784_10860	COG0583	DNA-binding transcription factor activity
H2784_10865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H2784_10870	COG1012	belongs to the aldehyde dehydrogenase family
H2784_10880	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H2784_10890	COG1012	belongs to the aldehyde dehydrogenase family
H2784_10895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2784_10900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2784_10905	COG2267	carboxylic ester hydrolase activity
H2784_10925	COG3038	cytochrome b561
H2784_10930	COG0753	catalase activity
H2784_10935	COG2271	Major facilitator Superfamily
H2784_10940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2784_10945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H2784_10960	COG2207	Transcriptional regulator
H2784_10985	COG2050	protein possibly involved in aromatic compounds catabolism
H2784_10995	COG3327	negative regulation of DNA-templated transcription, initiation
H2784_11000	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H2784_11005	COG0183	Belongs to the thiolase family
H2784_11010	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2784_11015	COG1024	Enoyl-CoA hydratase
H2784_11020	COG1024	Enoyl-CoA hydratase
H2784_11025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2784_11030	COG2151	metal-sulfur cluster biosynthetic enzyme
H2784_11035	COG3396	Phenylacetate-CoA oxygenase
H2784_11040	COG3460	Phenylacetate-CoA oxygenase
H2784_11045	COG3396	Phenylacetate-CoA oxygenase
H2784_11050	COG1012	belongs to the aldehyde dehydrogenase family
H2784_11050	COG2030	dehydratase
H2784_11055	COG1760	l-serine dehydratase
H2784_11060	COG0531	amino acid
H2784_11065	COG1012	belongs to the aldehyde dehydrogenase family
H2784_11090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H2784_11110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2784_11120	COG0789	Transcriptional regulator
H2784_11130	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H2784_11145	COG2807	transmembrane transport
H2784_11150	COG0590	tRNA wobble adenosine to inosine editing
H2784_11265	COG1116	anion transmembrane transporter activity
H2784_11270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H2784_11280	COG0864	Transcriptional regulator
H2784_11290	COG1733	regulation of RNA biosynthetic process
H2784_11295	COG2249	NAD(P)H dehydrogenase (quinone) activity
H2784_11300	COG0439	Biotin carboxylase
H2784_11315	COG1063	alcohol dehydrogenase
H2784_11340	COG3210	domain, Protein
H2784_11345	COG2831	hemolysin activation secretion protein
H2784_11350	COG0038	chloride channel
H2784_11355	COG4770	biotin carboxylase activity
H2784_11375	COG1914	H( )-stimulated, divalent metal cation uptake system
H2784_11380	COG0583	DNA-binding transcription factor activity
H2784_11415	COG1250	3-hydroxyacyl-CoA dehydrogenase
H2784_11435	COG2814	Major facilitator Superfamily
H2784_11445	COG1560	Kdo2-lipid A biosynthetic process
H2784_11460	COG1522	sequence-specific DNA binding
H2784_11475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H2784_11485	COG4122	O-methyltransferase activity
H2784_11515	COG1538	Outer membrane efflux protein
H2784_11520	COG1137	ATPase activity
H2784_11525	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H2784_11535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H2784_11540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H2784_11540	COG0517	IMP dehydrogenase activity
H2784_11585	COG2814	Major facilitator Superfamily
H2784_11620	COG1278	Cold shock
H2784_11625	COG1280	lysine exporter protein (LysE YggA)
H2784_11655	COG1570	exodeoxyribonuclease VII activity
H2784_11705	COG0583	DNA-binding transcription factor activity
H2784_11710	COG4638	Rieske (2fe-2S)
H2784_11715	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H2784_11720	COG0543	2 iron, 2 sulfur cluster binding
H2784_11720	COG0633	Ferredoxin
H2784_11725	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_11730	COG3135	benzoate transporter
H2784_11735	COG2814	Major facilitator Superfamily
H2784_11750	COG1643	Atp-dependent helicase
H2784_11755	COG0450	alkyl hydroperoxide reductase
H2784_11765	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H2784_11775	COG3634	alkyl hydroperoxide reductase activity
H2784_11795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H2784_11800	COG0625	glutathione transferase activity
H2784_11810	COG2885	chlorophyll binding
H2784_11840	COG1546	Belongs to the CinA family
H2784_11840	COG1058	Belongs to the CinA family
H2784_11845	COG0542	response to heat
H2784_11860	COG1765	OsmC-like protein
H2784_11870	COG0667	Aldo Keto reductase
H2784_11885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H2784_11900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H2784_11910	COG0527	aspartate kinase activity
H2784_11920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H2784_11930	COG3038	cytochrome b561
H2784_11935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H2784_11940	COG2252	PERMEase
H2784_11950	COG2072	flavoprotein involved in K transport
H2784_11965	COG1741	Belongs to the pirin family
H2784_11970	COG1309	transcriptional regulator
H2784_11980	COG0300	oxidoreductase activity
H2784_11985	COG2072	flavoprotein involved in K transport
H2784_11990	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H2784_12035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H2784_12050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H2784_12065	COG2814	Major facilitator Superfamily
H2784_12070	COG1024	Enoyl-CoA hydratase
H2784_12075	COG1012	belongs to the aldehyde dehydrogenase family
H2784_12085	COG1960	acyl-CoA dehydrogenase activity
H2784_12110	COG2186	Transcriptional regulator
H2784_12115	COG1012	belongs to the aldehyde dehydrogenase family
H2784_12125	COG4948	Mandelate Racemase Muconate Lactonizing
H2784_12130	COG2271	Major facilitator Superfamily
H2784_12135	COG2721	sulfolactate sulfo-lyase activity
H2784_12140	COG0697	spore germination
H2784_12175	COG1113	amino acid transport
H2784_12195	COG1012	belongs to the aldehyde dehydrogenase family
H2784_12215	COG0531	amino acid
H2784_12225	COG1113	amino acid transport
H2784_12295	COG4269	membrane
H2784_12310	COG1902	pentaerythritol trinitrate reductase activity
H2784_12310	COG0446	pyridine nucleotide-disulphide oxidoreductase
H2784_12320	COG2203	Gaf domain
H2784_12320	COG3706	GGDEF domain
H2784_12320	COG4251	negative regulation of phosphorylation
H2784_12320	COG5001	Diguanylate cyclase
H2784_12330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2784_12350	COG4172	Belongs to the ABC transporter superfamily
H2784_12355	COG4239	(ABC) transporter, permease
H2784_12360	COG4174	ABC transporter (Permease)
H2784_12370	COG1388	LysM domain
H2784_12370	COG0741	lytic transglycosylase activity
H2784_12370	COG1388	LysM domain
H2784_12370	COG0741	lytic transglycosylase activity
H2784_12375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H2784_12415	COG0583	DNA-binding transcription factor activity
H2784_12420	COG1279	arginine transmembrane transporter activity
H2784_12440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2784_12445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2784_12450	COG0006	proline dipeptidase activity
H2784_12535	COG0739	heme binding
H2784_12780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H2784_12805	COG3384	dioxygenase
H2784_12815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H2784_12820	COG2878	Part of a membrane complex involved in electron transport
H2784_12825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H2784_12850	COG0768	penicillin binding
H2784_12855	COG0742	ribosomal rna small subunit methyltransferase
H2784_12870	COG0830	nickel cation binding
H2784_12880	COG0804	urea catabolic process
H2784_12920	COG1253	flavin adenine dinucleotide binding
H2784_12925	COG2851	Citrate transporter
H2784_12985	COG1773	rubredoxin
H2784_12990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H2784_13000	COG0583	DNA-binding transcription factor activity
H2784_13030	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H2784_13035	COG4181	ATPase activity
H2784_13080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H2784_13100	COG0306	phosphate transporter
H2784_13110	COG3958	Transketolase
H2784_13115	COG3959	Transketolase, thiamine diphosphate binding domain
H2784_13120	COG2271	Major facilitator Superfamily
H2784_13125	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_13130	COG0583	DNA-binding transcription factor activity
H2784_13145	COG2223	nitrite transmembrane transporter activity
H2784_13150	COG2207	Transcriptional regulator
H2784_13155	COG2066	Belongs to the glutaminase family
H2784_13160	COG0242	peptide deformylase activity
H2784_13165	COG0477	Major facilitator Superfamily
H2784_13175	COG0028	Belongs to the TPP enzyme family
H2784_13190	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_13195	COG2267	carboxylic ester hydrolase activity
H2784_13205	COG2271	Major facilitator Superfamily
H2784_13220	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_13240	COG1414	Transcriptional regulator
H2784_13255	COG1024	Enoyl-CoA hydratase
H2784_13265	COG1215	transferase activity, transferring glycosyl groups
H2784_13270	COG1649	PFAM Uncharacterised BCR, COG1649
H2784_13270	COG0726	polysaccharide deacetylase
H2784_13280	COG4681	YaeQ
H2784_13290	COG0523	cobalamin synthesis protein
H2784_13300	COG1607	acyl-coa hydrolase
H2784_13310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2784_13315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H2784_13320	COG1309	transcriptional regulator
H2784_13345	COG2040	homocysteine
H2784_13350	COG0531	amino acid
H2784_13395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2784_13400	COG0477	Major facilitator Superfamily
H2784_13510	COG1476	TRANSCRIPTIONal
H2784_13540	COG0582	viral genome integration into host DNA
H2784_13550	COG0405	Gamma-glutamyltransferase
H2784_13555	COG2814	Major facilitator Superfamily
H2784_13565	COG2050	protein possibly involved in aromatic compounds catabolism
H2784_13580	COG1090	epimerase
H2784_13600	COG0420	3'-5' exonuclease activity
H2784_13625	COG0735	belongs to the Fur family
H2784_13630	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H2784_13650	COG0121	glutamine amidotransferase
H2784_13665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2784_13675	COG0210	DNA helicase
H2784_13680	COG2885	chlorophyll binding
H2784_13685	COG0204	Acyl-transferase
H2784_13700	COG2894	cell division
H2784_13720	COG1280	lysine exporter protein (LysE YggA)
H2784_13725	COG1674	ftsk spoiiie
H2784_13730	COG0492	ferredoxin-NADP+ reductase activity
H2784_13735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H2784_13745	COG0456	acetyltransferase
H2784_13790	COG1981	membrane
H2784_13805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2784_13805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H2784_13825	COG1012	belongs to the aldehyde dehydrogenase family
H2784_13835	COG0657	acetylesterase activity
H2784_13845	COG0473	3-isopropylmalate dehydrogenase activity
H2784_13850	COG0583	DNA-binding transcription factor activity
H2784_13870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2784_13895	COG0564	pseudouridine synthase activity
H2784_13905	COG0358	DNA primase activity
H2784_13920	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H2784_13950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H2784_13980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H2784_13990	COG0351	phosphomethylpyrimidine kinase
H2784_13990	COG0352	thiamine-phosphate diphosphorylase activity
H2784_13990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H2784_13995	COG1652	LysM domain
H2784_14020	COG1399	metal-binding, possibly nucleic acid-binding protein
H2784_14025	COG3101	peptidyl-lysine hydroxylation
H2784_14030	COG0009	L-threonylcarbamoyladenylate synthase
H2784_14035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H2784_14040	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H2784_14055	COG4106	trans-aconitate 2-methyltransferase activity
H2784_14070	COG2226	methyltransferase
H2784_14070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2784_14070	COG0596	Alpha beta hydrolase
H2784_14075	COG1877	trehalose-phosphatase activity
H2784_14080	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H2784_14085	COG2223	nitrite transmembrane transporter activity
H2784_14105	COG1196	nuclear chromosome segregation
H2784_14115	COG0730	response to heat
H2784_14130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H2784_14140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2784_14190	COG0489	protein tyrosine kinase activity
H2784_14200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2784_14200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2784_14230	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H2784_14235	COG2081	HI0933 family
H2784_14245	COG0668	transmembrane transport
H2784_14265	COG0583	DNA-binding transcription factor activity
H2784_14285	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H2784_14290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2784_14320	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H2784_14360	COG0745	RESPONSE REGULATOR receiver
H2784_14380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H2784_14430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H2784_14445	COG0583	DNA-binding transcription factor activity
H2784_14455	COG0583	DNA-binding transcription factor activity
H2784_14470	COG0583	DNA-binding transcription factor activity
H2784_14475	COG1053	succinate dehydrogenase
H2784_14485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H2784_14490	COG2814	Major facilitator Superfamily
H2784_14495	COG1960	acyl-CoA dehydrogenase activity
H2784_14500	COG0583	DNA-binding transcription factor activity
H2784_14505	COG1063	alcohol dehydrogenase
H2784_14535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H2784_14540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H2784_14545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2784_14565	COG2132	Multicopper oxidase
H2784_14575	COG0561	phosphatase activity
H2784_14580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H2784_14605	COG1214	PFAM Peptidase M22, glycoprotease
H2784_14655	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H2784_14665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H2784_14670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H2784_14675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H2784_14735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H2784_14745	COG1846	Transcriptional regulator
H2784_14750	COG1764	response to oxidative stress
H2784_14790	COG0037	tRNA processing
H2784_14800	COG0248	Ppx GppA phosphatase
H2784_14830	COG0072	phenylalanine-tRNA ligase activity
H2784_14870	COG1238	metal cluster binding
H2784_14875	COG0625	glutathione transferase activity
H2784_14890	COG0318	PFAM AMP-dependent synthetase and ligase
H2784_14895	COG3028	Belongs to the UPF0307 family
H2784_14900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H2784_14920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H2784_14925	COG0617	tRNA 3'-terminal CCA addition
H2784_14930	COG1555	photosystem II stabilization
H2784_14935	COG3956	TIGRFAM MazG family protein
H2784_14945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H2784_14965	COG2205	protein histidine kinase activity
H2784_14965	COG5002	protein histidine kinase activity
H2784_14965	COG0784	Response regulator, receiver
H2784_14970	COG1024	Enoyl-CoA hydratase
H2784_14975	COG2084	Dehydrogenase
H2784_14980	COG3622	Belongs to the hyi family
H2784_15010	COG0697	spore germination
H2784_15020	COG2814	Major facilitator Superfamily
H2784_15025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H2784_15035	COG0583	DNA-binding transcription factor activity
H2784_15045	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H2784_15055	COG0084	hydrolase, TatD family'
H2784_15070	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H2784_15100	COG0440	acetolactate synthase activity
H2784_15105	COG0028	Belongs to the TPP enzyme family
H2784_15130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H2784_15135	COG0577	efflux transmembrane transporter activity
H2784_15135	COG1136	(ABC) transporter
H2784_15140	COG1538	Outer membrane efflux protein
H2784_15155	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H2784_15160	COG1162	GTPase activity
H2784_15170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H2784_15210	COG1426	Protein conserved in bacteria
H2784_15245	COG0793	Belongs to the peptidase S41A family
H2784_15260	COG2267	carboxylic ester hydrolase activity
H2784_15275	COG3265	gluconokinase activity
H2784_15285	COG0800	Aldolase
H2784_15295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H2784_15300	COG0280	phosphate acetyltransferase
H2784_15300	COG0857	belongs to the CobB CobQ family
H2784_15305	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H2784_15305	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H2784_15325	COG0740	serine-type endopeptidase activity
H2784_15335	COG4774	siderophore transport
H2784_15345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H2784_15355	COG2813	Specifically methylates the guanine in position
H2784_15355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H2784_15455	COG0788	formyltetrahydrofolate deformylase activity
H2784_15480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2784_15480	COG4651	solute:proton antiporter activity
H2784_15500	COG0724	RNA recognition motif
H2784_15505	COG0210	DNA helicase
H2784_15530	COG1733	regulation of RNA biosynthetic process
H2784_15540	COG2900	Belongs to the SlyX family
H2784_15545	COG0488	(ABC) transporter
H2784_15550	COG1280	lysine exporter protein (LysE YggA)
H2784_15555	COG1560	Kdo2-lipid A biosynthetic process
H2784_15565	COG1301	dicarboxylic acid transport
H2784_15620	COG0473	3-isopropylmalate dehydrogenase activity
H2784_15685	COG0583	DNA-binding transcription factor activity
H2784_15695	COG0625	glutathione transferase activity
H2784_15700	COG2378	regulation of single-species biofilm formation
H2784_15705	COG0546	phosphoglycolate phosphatase activity
H2784_15715	COG1530	ribonuclease E activity
H2784_15720	COG0318	PFAM AMP-dependent synthetase and ligase
H2784_15735	COG0583	DNA-binding transcription factor activity
H2784_15740	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_15745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H2784_15755	COG0534	Mate efflux family protein
H2784_15770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H2784_15800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H2784_15800	COG0493	'glutamate synthase
H2784_15810	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H2784_15815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H2784_15830	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H2784_15840	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H2784_15840	COG0644	oxidoreductase
H2784_15845	COG0425	Belongs to the sulfur carrier protein TusA family
H2784_15850	COG4535	Mg2 and Co2 transporter CorC
H2784_15860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H2784_15880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H2784_15885	COG0475	glutathione-regulated potassium exporter activity
H2784_15885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H2784_15900	COG0484	heat shock protein binding
H2784_15905	COG0789	Transcriptional regulator
H2784_15910	COG0598	Magnesium transport protein CorA
H2784_15925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H2784_15930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H2784_15935	COG1074	ATP-dependent DNA helicase activity
H2784_15940	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H2784_15960	COG2226	methyltransferase
H2784_15975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H2784_15980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H2784_15995	COG2111	Na H antiporter
H2784_15995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H2784_16000	COG1006	Multisubunit Na H antiporter MnhC subunit
H2784_16005	COG0651	ATP synthesis coupled electron transport
H2784_16010	COG1863	multisubunit Na H antiporter MnhE subunit
H2784_16015	COG2212	antiporter activity
H2784_16020	COG1320	monovalent cation:proton antiporter activity
H2784_16035	COG0195	Participates in both transcription termination and antitermination
H2784_16085	COG0237	dephospho-CoA kinase activity
H2784_16095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H2784_16110	COG0497	DNA recombination
H2784_16120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H2784_16150	COG2169	Transcriptional regulator
H2784_16150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H2784_16155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H2784_16205	COG0789	Transcriptional regulator
H2784_16215	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H2784_16230	COG0326	Molecular chaperone. Has ATPase activity
H2784_16245	COG2056	Na+-H+ antiporter family
H2784_16345	COG0546	phosphoglycolate phosphatase activity
H2784_16350	COG1716	ATPase activity
H2784_16395	COG0181	hydroxymethylbilane synthase activity
H2784_16405	COG3275	phosphorelay sensor kinase activity
H2784_16430	COG0697	spore germination
H2784_16455	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H2784_16460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H2784_16465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H2784_16470	COG0772	Belongs to the SEDS family
H2784_16495	COG4974	Belongs to the 'phage' integrase family
H2784_16500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2784_16510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H2784_16520	COG2197	response regulator
H2784_16535	COG0793	Belongs to the peptidase S41A family
H2784_16540	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H2784_16545	COG0795	lipopolysaccharide-transporting ATPase activity
H2784_16585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2784_16585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H2784_16595	COG0004	ammonium transporteR
H2784_16600	COG0347	Belongs to the P(II) protein family
H2784_16610	COG0606	chelatase, subunit chli
H2784_16615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H2784_16620	COG0235	Class ii aldolase
H2784_16625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H2784_16640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H2784_16655	COG0318	PFAM AMP-dependent synthetase and ligase
H2784_16665	COG0477	Major facilitator Superfamily
H2784_16670	COG2860	membrane
H2784_16675	COG3012	SEC-C Motif Domain Protein
H2784_16680	COG1253	flavin adenine dinucleotide binding
H2784_16690	COG0477	Major facilitator Superfamily
H2784_16700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H2784_16735	COG0655	NAD(P)H dehydrogenase (quinone) activity
H2784_16745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H2784_16780	COG1309	transcriptional regulator
H2784_16815	COG0758	DNA mediated transformation
H2784_16825	COG0697	spore germination
H2784_16830	COG1309	transcriptional regulator
H2784_16845	COG0386	Belongs to the glutathione peroxidase family
H2784_16910	COG1121	(ABC) transporter
H2784_16915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H2784_16920	COG1280	lysine exporter protein (LysE YggA)
H2784_16925	COG2837	iron assimilation
H2784_16930	COG0281	malic enzyme
H2784_16975	COG0519	Catalyzes the synthesis of GMP from XMP
H2784_16975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H2784_16980	COG4399	Belongs to the UPF0754 family
H2784_16985	COG2259	Doxx family
H2784_16990	COG0586	Pfam SNARE associated Golgi protein
H2784_17005	COG1192	Involved in chromosome partitioning
H2784_17015	COG0271	Belongs to the BolA IbaG family
H2784_17055	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H2784_17055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H2784_17055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H2784_17055	COG3321	synthase
H2784_17060	COG1960	acyl-CoA dehydrogenase activity
H2784_17070	COG2197	response regulator
H2784_17080	COG3916	Acyl-homoserine-lactone synthase
H2784_17085	COG0477	Major facilitator Superfamily
H2784_17090	COG1024	Enoyl-CoA hydratase
H2784_17095	COG1024	Enoyl-CoA hydratase
H2784_17100	COG1960	acyl-CoA dehydrogenase activity
H2784_17105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H2784_17125	COG1113	amino acid transport
H2784_17130	COG1113	amino acid transport
H2784_17135	COG0251	oxidation-reduction process
H2784_17175	COG0564	pseudouridine synthase activity
H2784_17245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H2784_17260	COG1802	Transcriptional regulator
H2784_17270	COG1448	Aminotransferase
H2784_17275	COG0277	FAD linked oxidase domain protein
H2784_17285	COG2186	Transcriptional regulator
H2784_17295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H2784_17300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H2784_17315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H2784_17320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H2784_17325	COG1216	Glycosyl transferase, family 2
H2784_17345	COG2244	polysaccharide biosynthetic process
H2784_17350	COG1216	Glycosyl transferase, family 2
H2784_17355	COG2089	acid synthase
H2784_17370	COG1083	cytidylyl-transferase
H2784_17375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H2784_17380	COG1086	Polysaccharide biosynthesis protein
H2784_17385	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H2784_17415	COG0728	peptidoglycan biosynthetic process
H2784_17420	COG3023	N-Acetylmuramoyl-L-alanine amidase
H2784_17480	COG0546	phosphoglycolate phosphatase activity
H2784_17485	COG1028	Short-chain dehydrogenase reductase Sdr
H2784_17505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2784_17510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H2784_17515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H2784_17520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H2784_17525	COG1116	anion transmembrane transporter activity
H2784_17530	COG1309	transcriptional regulator
H2784_17535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H2784_17545	COG0196	riboflavin kinase activity
H2784_17550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H2784_17560	COG1047	Peptidyl-prolyl cis-trans
H2784_17600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H2784_17605	COG0657	acetylesterase activity
H2784_17655	COG2951	lytic endotransglycosylase activity
H2784_17660	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H2784_17675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H2784_17685	COG0671	phosphoesterase, PA-phosphatase related
H2784_17690	COG0861	Integral membrane protein TerC family
H2784_17700	COG0754	glutathionylspermidine amidase activity
H2784_17710	COG0402	S-adenosylhomocysteine deaminase activity
H2784_17725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H2784_17730	COG1230	cation diffusion facilitator family transporter
H2784_17745	COG0706	membrane insertase activity