locus-tag class description FZN67_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FZN67_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FZN67_00030 ENOG4105DQR SNARE associated Golgi FZN67_00035 ENOG4105C5H ABC transporter FZN67_00040 ENOG4108821 RND type efflux pump FZN67_00045 ENOG4108821 RND type efflux pump FZN67_00050 ENOG4108821 RND type efflux pump FZN67_00060 ENOG4105D74 hydrolase FZN67_00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FZN67_00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FZN67_00125 ENOG4107RYR Transcriptional regulator, Crp Fnr family FZN67_00130 ENOG4108UKZ OsmC family FZN67_00150 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FZN67_00180 ENOG4105C2W permease FZN67_00190 ENOG4108IG5 Transcriptional regulator FZN67_00195 ENOG4105DJY efflux transporter, rnd family, mfp subunit FZN67_00230 ENOG4105F27 Major Facilitator FZN67_00235 ENOG4105CV8 reductase FZN67_00240 ENOG4105HEI LysR family (Transcriptional regulator FZN67_00260 ENOG4105DQ4 alcohol dehydrogenase FZN67_00265 ENOG4108R3E Dna-3-methyladenine glycosylase i FZN67_00280 ENOG4105CEN a g-specific adenine glycosylase FZN67_00300 ENOG4108ZZ3 UPF0260 protein FZN67_00310 ENOG4105D1H recombination factor protein RarA FZN67_00315 ENOG4105S64 Formate nitrite transporter FZN67_00335 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FZN67_00340 ENOG4108RWI nicotinamidase FZN67_00345 ENOG4105C09 Bile acid FZN67_00350 ENOG4107QI1 Mate efflux family protein FZN67_00355 ENOG4105EWC Purine nucleoside phosphorylase FZN67_00375 ENOG4108RXX maleylacetoacetate isomerase FZN67_00385 ENOG4105C85 amino acid FZN67_00395 ENOG4105CKI cobalamin synthesis protein FZN67_00405 ENOG4105CZE histidine utilization repressor FZN67_00410 ENOG41090B9 response to stress FZN67_00425 ENOG4105C85 amino acid FZN67_00435 ENOG41088SP formiminoglutamate hydrolase FZN67_00450 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FZN67_00455 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FZN67_00465 ENOG4108ZAI phosphatidylglycerophosphatase a FZN67_00470 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FZN67_00485 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FZN67_00525 ENOG4105KHC sulfurtransferase FZN67_00555 ENOG4105BZU Histidine kinase FZN67_00560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FZN67_00575 ENOG4107QJQ Mate efflux family protein FZN67_00580 ENOG4105CHM Aminotransferase FZN67_00585 ENOG4106BRA Membrane FZN67_00600 ENOG4105D9M gamma-glutamylcysteine synthetase FZN67_00610 ENOG4105CS6 Rhs element vgr protein FZN67_00615 ENOG4105K4H Nlp p60 protein FZN67_00635 ENOG4105IPS esterase FZN67_00640 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FZN67_00645 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FZN67_00650 ENOG4108Z2U ureidoglycolate hydrolase FZN67_00660 ENOG41061H0 Monooxygenase FZN67_00675 ENOG41084YZ Hydrolase FZN67_00705 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FZN67_00710 ENOG4105BZU Histidine kinase FZN67_00725 ENOG4105KUZ arsenate reductase FZN67_00730 ENOG4105CGK Exodeoxyribonuclease III FZN67_00750 ENOG4105D7Z glutathione synthase FZN67_00770 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FZN67_00775 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FZN67_00780 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FZN67_00795 ENOG41063SB peptidase FZN67_00800 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FZN67_00805 ENOG4107QSN dihydrolipoamide acetyltransferase FZN67_00845 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FZN67_00860 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FZN67_00880 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FZN67_00885 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FZN67_00895 ENOG4105D64 Mechanosensitive ion channel FZN67_00905 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FZN67_00910 ENOG4108W2Y isochorismatase FZN67_00920 ENOG4105D5G Transposase FZN67_00925 ENOG4105FBW Monooxygenase FZN67_00930 ENOG4108UZX fmn reductase FZN67_00945 ENOG4105BZU Histidine kinase FZN67_00950 ENOG41062QD Membrane FZN67_00955 ENOG4107QN1 sodium solute FZN67_00965 ENOG4105D5G Transposase FZN67_00970 ENOG4105C94 Transporter FZN67_00980 ENOG4105BZU Histidine kinase FZN67_00990 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FZN67_00995 ENOG4108WUH Transcriptional regulator, TetR family FZN67_01000 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FZN67_01010 ENOG4105RA2 Membrane FZN67_01015 ENOG4105DWF phosphomethylpyrimidine kinase FZN67_01025 ENOG4107RDB Major Facilitator FZN67_01030 ENOG4108UUM single-stranded DNA-binding protein FZN67_01040 ENOG4108UMN azlc family FZN67_01050 ENOG4105C85 amino acid FZN67_01060 ENOG4108JPW Aminotransferase FZN67_01065 ENOG4105C26 Dehydrogenase FZN67_01075 ENOG4105CHJ isochorismatase hydrolase FZN67_01080 ENOG4105EUB pirin domain protein FZN67_01105 ENOG4105D94 Major Facilitator Superfamily FZN67_01110 ENOG4106NZI LysR family Transcriptional regulator FZN67_01130 ENOG4105CPC Aldo Keto reductase FZN67_01135 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) FZN67_01205 ENOG4105CUV Homoserine Kinase FZN67_01220 ENOG41061CK Antibiotic biosynthesis monooxygenase FZN67_01250 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FZN67_01280 ENOG4105CYC Transferase FZN67_01290 ENOG4105E0F Histidine kinase FZN67_01295 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FZN67_01305 ENOG4105CHH sulfate transporter FZN67_01310 ENOG4105PDP Short chain dehydrogenase FZN67_01320 ENOG4105C5H ABC transporter FZN67_01405 ENOG4108IQI permease FZN67_01430 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FZN67_01445 ENOG4105CJN penicillin-binding protein FZN67_01450 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FZN67_01455 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FZN67_01470 ENOG4105DHI Methyltransferase FZN67_01475 ENOG4108JQC penicillin-binding protein 1A FZN67_01500 ENOG4105E4G Type IV pilus FZN67_01520 ENOG4105CBC glutamate synthase FZN67_01525 ENOG4105BZ8 glutamate synthase FZN67_01535 ENOG4108V0P LemA family FZN67_01540 ENOG4105HA9 of methanol dehydrogenase type FZN67_01560 ENOG4108YSG O-Antigen polymerase FZN67_01565 ENOG4108UQY Iron-storage protein FZN67_01575 ENOG4105KME endoribonuclease L-psp FZN67_01580 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FZN67_01595 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FZN67_01645 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FZN67_01660 ENOG4107IFA Lipase (EC 3.1.1.3) FZN67_01665 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) FZN67_01670 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FZN67_01695 ENOG4108JQ1 Dehydrogenase FZN67_01700 ENOG4105CQB FAD linked oxidase domain protein FZN67_01710 ENOG4105VRH Antibiotic biosynthesis monooxygenase FZN67_01715 ENOG4105NF4 modulator of drug activity FZN67_01725 ENOG4107QF7 multi-drug FZN67_01730 ENOG4105EM2 membrane FZN67_01735 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FZN67_01740 ENOG4105IPI Membrane FZN67_01745 ENOG4107SKI cobyrinic Acid a,c-diamide synthase FZN67_01775 ENOG4108IQI permease FZN67_01780 ENOG4105D82 Glutamate dehydrogenase FZN67_01785 ENOG4105C8Y Acetylornithine aminotransferase FZN67_01795 ENOG4105C26 Dehydrogenase FZN67_01820 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FZN67_01880 ENOG4105W87 Cbs domain FZN67_01885 ENOG41067S9 phage shock protein C, PspC FZN67_01895 ENOG4105CSU acyl-Coa dehydrogenase FZN67_01905 ENOG4108HWY Beta-lactamase FZN67_01925 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FZN67_01940 ENOG4105ECY inositol monophosphatase FZN67_01945 ENOG4105C1J atp-dependent rna helicase FZN67_01955 ENOG4105DHJ ABC, transporter FZN67_01960 ENOG4105CY3 ABC transporter, permease FZN67_01970 ENOG4105E3I toluene tolerance FZN67_01980 ENOG4105D7N magnesium and cobalt transport protein CorA FZN67_01985 ENOG4108URH decarboxylase FZN67_01995 ENOG4105MJ2 Competence protein FZN67_02000 ENOG4105CB5 ATP-dependent DNA helicase recG FZN67_02020 ENOG4105C29 acyl-CoA thioesterase FZN67_02025 ENOG4105CK2 sodium dicarboxylate symporter FZN67_02040 ENOG4105KPV Transcriptional regulator FZN67_02050 ENOG4105D7A ATP-binding protein FZN67_02055 ENOG4105C28 cystathionine FZN67_02060 ENOG41089BK Glutamine amido-transferase FZN67_02170 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FZN67_02175 ENOG41067V7 50S ribosomal protein L36 FZN67_02185 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FZN67_02210 ENOG4105C1G acyl-Coa dehydrogenase FZN67_02245 ENOG4105VKU nucleicacid-binding protein FZN67_02250 ENOG4105DGW oligopeptidase A FZN67_02255 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FZN67_02300 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FZN67_02305 ENOG4108K2B transcriptional regulator FZN67_02315 ENOG4107S2Z UPF0761 membrane protein FZN67_02320 ENOG4105CS1 NAD(P)H quinone oxidoreductase FZN67_02350 ENOG4105C9A Phoh family FZN67_02360 ENOG4105E4C Lytic transglycosylase catalytic FZN67_02390 ENOG4105D6S protein involved in catabolism of external DNA FZN67_02395 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FZN67_02440 ENOG4105C1G acyl-Coa dehydrogenase FZN67_02445 ENOG4108RZE Tetr family transcriptional regulator FZN67_02460 ENOG4107QX3 carboxylase FZN67_02465 ENOG4105C1G acyl-Coa dehydrogenase FZN67_02485 ENOG4105KB2 stringent starvation protein b FZN67_02490 ENOG4107MKT Stringent starvation protein a FZN67_02495 ENOG4108UJD 30S ribosomal protein S9 FZN67_02505 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FZN67_02510 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FZN67_02515 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FZN67_02535 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FZN67_02545 ENOG4107RZC phospholipase d FZN67_02555 ENOG4105UYK outer membrane protein a FZN67_02560 ENOG4108KHX Diguanylate cyclase FZN67_02595 ENOG4107QN2 dihydrolipoyl dehydrogenase FZN67_02605 ENOG4107QPB Beta-lactamase domain protein FZN67_02610 ENOG4107U2T alpha beta FZN67_02620 ENOG4105NAU thioesterase Superfamily protein FZN67_02650 ENOG4105K9H YciI-like protein FZN67_02660 ENOG4105DB7 PHP domain protein FZN67_02665 ENOG4105FFC UPF0187 protein FZN67_02675 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FZN67_02680 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FZN67_02685 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FZN67_02690 ENOG4105VIE preprotein translocase, subunit YajC FZN67_02740 ENOG4105BZU Histidine kinase FZN67_02745 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FZN67_02750 ENOG4105CM2 brancheD-chain amino acid aminotransferase FZN67_02765 ENOG4107BJW polysaccharide deacetylase FZN67_02775 ENOG4108PQP glycosyl transferase group 1 FZN67_02800 ENOG4107RYR Transcriptional regulator, Crp Fnr family FZN67_02805 ENOG4108UKZ OsmC family FZN67_02840 ENOG4105UGU tonB-dependent Receptor FZN67_02860 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FZN67_02865 ENOG4108K3A Glutathione S-transferase FZN67_02870 ENOG4108R4R Iron-regulated virulence regulatory protein FZN67_02875 ENOG4105CSU acyl-Coa dehydrogenase FZN67_02880 ENOG4105CSU acyl-Coa dehydrogenase FZN67_02890 ENOG4105EB3 Histidine kinase FZN67_02895 ENOG4105E3W Two component transcriptional regulator (Winged helix family FZN67_02900 ENOG4105CNG UPF0061 protein FZN67_02920 ENOG4108WBT adenosyltransferase FZN67_02935 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FZN67_02970 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FZN67_02990 ENOG4105D3R alkyl hydroperoxide reductase FZN67_03005 ENOG4105CSH Transporter FZN67_03010 ENOG4108UT2 hemolysin iii FZN67_03040 ENOG4105CHU acetyl-coa acetyltransferase FZN67_03045 ENOG4108R6W Transcriptional regulator, ARAC family FZN67_03055 ENOG4105TW1 Carbohydrate-selective porin OprB FZN67_03060 ENOG4105DZG Dehydrogenase FZN67_03065 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FZN67_03085 ENOG4105CHU acetyl-coa acetyltransferase FZN67_03095 ENOG4108WHA ompa motb domain protein FZN67_03105 ENOG4105E0Y RtcB Protein FZN67_03110 ENOG4108IQI permease FZN67_03120 ENOG4105C2W permease FZN67_03140 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FZN67_03150 ENOG4108VX5 3-methyladenine DNA glycosylase FZN67_03155 ENOG4105CHB tonB-dependent Receptor FZN67_03170 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FZN67_03175 ENOG4108N2Y auxin Efflux FZN67_03185 ENOG4105T95 Thiol disulfide interChange protein FZN67_03190 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FZN67_03200 ENOG4105K78 MarR family Transcriptional regulator FZN67_03205 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FZN67_03210 ENOG4105KWI UPF0339 protein FZN67_03235 ENOG4108UNF response regulator FZN67_03240 ENOG4105M3Z response regulator FZN67_03245 ENOG4108ZGA chew protein FZN67_03250 ENOG4105C8Q Methyl-accepting chemotaxis FZN67_03255 ENOG4105CBS Chea signal transduction histidine kinase FZN67_03270 ENOG4106HKS Entericidin EcnA/B family FZN67_03280 ENOG4105WD1 Membrane FZN67_03285 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FZN67_03325 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FZN67_03335 ENOG4105EM2 membrane FZN67_03340 ENOG4105C2C drug resistance transporter, Bcr CflA FZN67_03360 ENOG4105BZG amino acid carrier protein FZN67_03365 ENOG4105D78 K07001 NTE family protein FZN67_03370 ENOG4105C7B Threonine dehydratase FZN67_03405 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FZN67_03415 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FZN67_03420 ENOG4105DFF Rod shape-determining protein mreb FZN67_03425 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FZN67_03430 ENOG4105VQ7 Rod shape-determining protein MreD FZN67_03435 ENOG4108Z03 MAF-like protein FZN67_03440 ENOG4105C03 ribonuclease FZN67_03450 ENOG4105D8T Acyltransferase FZN67_03460 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein FZN67_03470 ENOG4108X0B nad(p)h dehydrogenase (quinone) FZN67_03495 ENOG4105CF7 AraC family transcriptional regulator FZN67_03515 ENOG4105C85 amino acid FZN67_03520 ENOG4105C7F AcnD-accessory protein PrpF FZN67_03525 ENOG4105CTB Polyprenyl synthetase FZN67_03530 ENOG4105MSB protein, conserved in bacteria FZN67_03545 ENOG4105D78 K07001 NTE family protein FZN67_03565 ENOG4105DIJ Phosphoethanolamine transferase FZN67_03570 ENOG4105XJC Two component transcriptional regulator (Winged helix family FZN67_03595 ENOG4108M0I Transcriptional regulator FZN67_03615 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FZN67_03635 ENOG4105K8R UPF0145 protein FZN67_03640 ENOG4105K8R UPF0145 protein FZN67_03645 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FZN67_03650 ENOG4105BZS acriflavin resistance protein FZN67_03655 ENOG4105C1P efflux transporter, rnd family, mfp subunit FZN67_03660 ENOG410841Q phosphoesterase PA-phosphatase related protein FZN67_03690 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FZN67_03705 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FZN67_03710 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FZN67_03715 ENOG4105KVH Transcriptional regulator FZN67_03725 ENOG4105CUB amino acid FZN67_03740 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FZN67_03745 ENOG41084BA UPF0250 protein FZN67_03750 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FZN67_03785 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FZN67_03790 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FZN67_03800 ENOG4105E33 succinate dehydrogenase FZN67_03815 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FZN67_03820 ENOG4105C7S Dehydrogenase FZN67_03825 ENOG4107QN2 dihydrolipoyl dehydrogenase FZN67_03835 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FZN67_03845 ENOG4105CKW Inner membrane protein yedI FZN67_03850 ENOG4105CGZ zinc metallopeptidase FZN67_03855 ENOG4105EEQ Na H antiporter FZN67_03890 ENOG4105PNM synthesis protein FZN67_03905 ENOG41080TK Universal stress protein FZN67_03920 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FZN67_03925 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FZN67_03940 ENOG4105HBR Rna-binding protein FZN67_03950 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FZN67_03955 ENOG4105EEI dihydropteroate synthase FZN67_04005 ENOG4105CSH Transporter FZN67_04010 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FZN67_04015 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FZN67_04030 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FZN67_04050 ENOG41080IJ Diacylglycerol kinase FZN67_04060 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FZN67_04065 ENOG4105BZS acriflavin resistance protein FZN67_04080 ENOG4105E4C Lytic transglycosylase catalytic FZN67_04105 ENOG4108RRZ Transcription elongation factor GreB FZN67_04120 ENOG4105CEY Amp-dependent synthetase and ligase FZN67_04165 ENOG4105BZW Glycerate kinase FZN67_04170 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FZN67_04175 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FZN67_04190 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FZN67_04200 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FZN67_04205 ENOG4105C85 amino acid FZN67_04215 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FZN67_04225 ENOG4105N14 lysine exporter protein LysE YggA FZN67_04230 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FZN67_04235 ENOG4105BZJ Electron transfer flavoprotein FZN67_04240 ENOG4105C10 Electron transfer flavoprotein FZN67_04245 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FZN67_04280 ENOG4107KET secretion protein, HlyD family FZN67_04310 ENOG4105D60 lipoprotein releasing system transmembrane protein FZN67_04315 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FZN67_04320 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FZN67_04330 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FZN67_04335 ENOG4107R6F Alpha Beta Hydrolase Fold protein FZN67_04340 ENOG4108V3E phosphoribosylglycinamide formyltransferase FZN67_04350 ENOG4105C02 permease FZN67_04400 ENOG4105KCK Peptidoglycan-associated lipoprotein FZN67_04405 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FZN67_04415 ENOG4105M8F Biopolymer transport protein exbD tolR FZN67_04420 ENOG4105E02 MotA TolQ exbB proton channel FZN67_04425 ENOG4107YD3 Thioesterase FZN67_04430 ENOG4105CH2 amidohydrolase FZN67_04450 ENOG4108ETH Formylglycinamide ribotide synthetase FZN67_04455 ENOG4105C2C drug resistance transporter, Bcr CflA FZN67_04460 ENOG4105EGD dinuclear metal center protein, YbgI family FZN67_04465 ENOG4108UKI Enoyl-CoA hydratase FZN67_04480 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FZN67_04495 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FZN67_04500 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FZN67_04515 ENOG4107R11 Transcriptional regulator FZN67_04520 ENOG4108IJ6 ABC transporter FZN67_04530 ENOG4108I5D sulfate abc transporter FZN67_04540 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FZN67_04545 ENOG4105YAZ 4-amino-4-deoxychorismate lyase FZN67_04550 ENOG4105HHA aminodeoxychorismate lyase FZN67_04565 ENOG4108IYU L-aspartate oxidase FZN67_04570 ENOG4105C0H protease FZN67_04585 ENOG4105C3F Signal peptidase i FZN67_04600 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FZN67_04610 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FZN67_04615 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FZN67_04620 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FZN67_04625 ENOG4105EMU Dehydrogenase FZN67_04665 ENOG4105BZU Histidine kinase FZN67_04675 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FZN67_04685 ENOG4105DTR rard protein FZN67_04720 ENOG4107QS8 (LipO)protein FZN67_04725 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FZN67_04730 ENOG4105EA8 2-Nitropropane dioxygenase FZN67_04760 ENOG4107R8N Glycosyl transferase, family 2 FZN67_04775 ENOG4105CVP deoxyribo-dipyrimidine photolyase FZN67_04780 ENOG4108YZY peptidylprolyl cis-trans isomerase FZN67_04785 ENOG4105CEP NADH dehydrogenase FZN67_04790 ENOG4105DZ1 carboxypeptidase FZN67_04800 ENOG4105E9K Isocitrate dehydrogenase FZN67_04805 ENOG4108R99 pseudouridine synthase FZN67_04830 ENOG4105CBP Major Facilitator FZN67_04835 ENOG4105EGI Transcriptional regulator FZN67_04840 ENOG4108ETY sodium dicarboxylate symporter FZN67_04845 ENOG4105JAB phenazine biosynthesis protein, phzf family FZN67_04880 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FZN67_04895 ENOG4105D3G Pseudouridine synthase FZN67_04900 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FZN67_04915 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FZN67_04940 ENOG4108JPW Aminotransferase FZN67_04945 ENOG4105DY8 decarboxylase FZN67_04955 ENOG4105F7P transcriptional regulator AsnC family FZN67_04960 ENOG4107RA9 decarboxylase FZN67_04965 ENOG4105C85 amino acid FZN67_04970 ENOG4105CVA phosphate FZN67_04975 ENOG4105C8U phosphate abc transporter FZN67_04985 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FZN67_04990 ENOG4105ERU peptidase FZN67_05005 ENOG4107QTF adenylosuccinate lyase FZN67_05025 ENOG4108Z0R Transferase FZN67_05030 ENOG4105DZ1 carboxypeptidase FZN67_05050 ENOG4108K5P (LipO)protein FZN67_05055 ENOG4105EJC lysr family transcriptional regulator FZN67_05060 ENOG4105DAN ATP-dependent protease FZN67_05075 ENOG4105DHU Bile acid FZN67_05105 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FZN67_05115 ENOG4105D22 carbon starvation protein FZN67_05120 ENOG4105VCD cytoplasmic protein FZN67_05155 ENOG4108K8K Transcriptional regulator FZN67_05170 ENOG4105C26 Dehydrogenase FZN67_05175 ENOG4105C85 amino acid FZN67_05180 ENOG4105ETT transcriptional Regulator, LysR family FZN67_05185 ENOG4105C94 Transporter FZN67_05190 ENOG4105C94 Transporter FZN67_05200 ENOG4105C26 Dehydrogenase FZN67_05205 ENOG4107QZF nitrite reductase NADPH large subunit FZN67_05210 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FZN67_05240 ENOG41060M8 Pfam:PhdYeFM FZN67_05245 ENOG4107QNK )-transporter FZN67_05250 ENOG4107WEA mandelate racemase muconate lactonizing FZN67_05260 ENOG4105J7D transcriptional regulator FZN67_05280 ENOG4105C2I pirin domain protein FZN67_05295 ENOG4108UKZ OsmC family FZN67_05300 ENOG4107RYR Transcriptional regulator, Crp Fnr family FZN67_05310 ENOG4105WWK YheO domain protein FZN67_05325 ENOG4105CEY Amp-dependent synthetase and ligase FZN67_05340 ENOG4108IPW abc transporter atp-binding protein FZN67_05360 ENOG4105C0W non-ribosomal peptide synthetase FZN67_05365 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FZN67_05370 ENOG4105WQI isochorismatase FZN67_05385 ENOG4105BZ1 (ABC) transporter FZN67_05405 ENOG4105E4F Isochorismate synthase FZN67_05420 ENOG4105NX3 Membrane FZN67_05445 ENOG4105EUJ GTP cyclohydrolase i FZN67_05455 ENOG4105C7W Xanthine dehydrogenase FZN67_05485 ENOG4105CD8 aminopeptidase N FZN67_05490 ENOG4105DDQ anthranilate synthase FZN67_05500 ENOG4105DUX Transporter FZN67_05505 ENOG4105C5F glutamine synthetase FZN67_05515 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FZN67_05550 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FZN67_05555 ENOG4107QNR UPF0135 protein FZN67_05560 ENOG4105C0H protease FZN67_05570 ENOG4105C6K Malic enzyme FZN67_05575 ENOG4105BZU Histidine kinase FZN67_05580 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FZN67_05585 ENOG4105SYT Methylenetetrahydrofolate reductase FZN67_05590 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FZN67_05605 ENOG4107QPN acyl-Coa dehydrogenase FZN67_05610 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FZN67_05615 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FZN67_05625 ENOG4107RNU major facilitator superfamily MFS_1 FZN67_05635 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FZN67_05640 ENOG4105CE9 30S ribosomal protein S2 FZN67_05680 ENOG4105CVE Lytic murein transglycosylase FZN67_05685 ENOG4105CNI cell division protein FtsW FZN67_05700 ENOG4105E3A (ABC) transporter FZN67_05705 ENOG4105DA5 (ABC) transporter FZN67_05740 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FZN67_05750 ENOG4105ENT Efflux transporter rnd family, mfp subunit FZN67_05760 ENOG4105E89 ABC transporter FZN67_05765 ENOG4105DSP amino acid AbC transporter FZN67_05770 ENOG4106YG3 ABC transporter FZN67_05775 ENOG4108JEH abc transporter atp-binding protein FZN67_05785 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FZN67_05790 ENOG4105CFP Peptidase U32 FZN67_05795 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FZN67_05800 ENOG4105JAB phenazine biosynthesis protein, phzf family FZN67_05805 ENOG4105DP0 ferredoxin-NADP reductase FZN67_05810 ENOG4108R96 Methyltransferase, YaeB family FZN67_05820 ENOG4107QHF type ii secretion system protein e FZN67_05830 ENOG4105XJC Two component transcriptional regulator (Winged helix family FZN67_05835 ENOG4105DHQ Histidine kinase FZN67_05845 ENOG4105M6F mutator MutT protein FZN67_05855 ENOG4105BZ4 penicillin-binding protein FZN67_05860 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FZN67_05865 ENOG4105VUT cytoplasmic protein FZN67_05870 ENOG4107QYG anthranilate phosphoribosyltransferase FZN67_05880 ENOG4105CK2 sodium dicarboxylate symporter FZN67_05885 ENOG4105C1G acyl-Coa dehydrogenase FZN67_05890 ENOG4105NIV Esterase FZN67_05895 ENOG4105CQC Prephenate dehydratase FZN67_05900 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FZN67_05910 ENOG4105CIN aminoacyl-histidine dipeptidase FZN67_05915 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FZN67_05945 ENOG4105M08 Membrane FZN67_05950 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FZN67_05960 ENOG4105VEQ Cold shock protein FZN67_05965 ENOG4105C1J atp-dependent rna helicase FZN67_05975 ENOG41069NU Nitroreductase FZN67_06010 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FZN67_06025 ENOG4105C5I Dehydrogenase FZN67_06030 ENOG4105ERG peptidase m48, ste24p FZN67_06035 ENOG4105KTH gatB Yqey FZN67_06040 ENOG4105VCC 30S ribosomal protein S21 FZN67_06065 ENOG4105D9P serine threonine protein kinase FZN67_06090 ENOG4105EVZ LysR family transcriptional regulator FZN67_06095 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FZN67_06100 ENOG4105C26 Dehydrogenase FZN67_06135 ENOG4105H4F exported protein FZN67_06165 ENOG4105D6U Sodium Glutamate Symporter FZN67_06240 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FZN67_06295 ENOG4105CK2 sodium dicarboxylate symporter FZN67_06305 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FZN67_06310 ENOG4108UMI ABC transporter, permease FZN67_06315 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FZN67_06325 ENOG4105C12 Phosphoribosylglycinamide synthetase FZN67_06330 ENOG4105DC1 bifunctional purine biosynthesis protein purh FZN67_06335 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FZN67_06385 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FZN67_06390 ENOG4105CDU Replicative dna helicase FZN67_06415 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FZN67_06420 ENOG4105CCU oxidase (Subunit III) FZN67_06425 ENOG4105BZ9 Cytochrome C oxidase, subunit I FZN67_06430 ENOG4105E2S oxidase) subunit II FZN67_06455 ENOG4107BJW polysaccharide deacetylase FZN67_06460 ENOG4105CND Glycosyl transferase, family 2 FZN67_06465 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD FZN67_06475 ENOG4105DEN Luciferase family FZN67_06495 ENOG4105CC0 LysR family Transcriptional regulator FZN67_06510 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FZN67_06515 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FZN67_06520 ENOG4105GVF (ABC) transporter FZN67_06535 ENOG4105C1G acyl-Coa dehydrogenase FZN67_06545 ENOG4108MEJ flavin reductase domain protein FZN67_06550 ENOG4105D06 uba thif-type nad fad binding protein FZN67_06570 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FZN67_06575 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FZN67_06585 ENOG4105C08 Histidine kinase FZN67_06590 ENOG4105EEX Two component transcriptional regulator (Winged helix family FZN67_06595 ENOG4105CFQ glutamine synthetase FZN67_06610 ENOG4107S74 Lysophospholipid transporter LplT FZN67_06615 ENOG4105CFU surface antigen FZN67_06635 ENOG4107QIJ Aconitate hydratase 2 FZN67_06645 ENOG4105EYW Ion transport protein FZN67_06650 ENOG4105F27 Major Facilitator FZN67_06665 ENOG4105DZ2 Transcriptional regulator FZN67_06700 ENOG4105K8N protein family UPF0079, ATPase FZN67_06705 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FZN67_06715 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FZN67_06720 ENOG4108TZV Membrane FZN67_06725 ENOG4108RCM Nitroreductase FZN67_06735 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FZN67_06750 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FZN67_06755 ENOG4107FQ9 ethanolamine ammonia-lyase FZN67_06760 ENOG4105CPD ethanolamine ammonia-lyase FZN67_06765 ENOG4107R55 ethanolamine transporter FZN67_06775 ENOG4107RR1 TRANSCRIPTIONal FZN67_06800 ENOG4107QUV Domain protein FZN67_06810 ENOG4105F4I Transcriptional regulator FZN67_06830 ENOG4105CD8 aminopeptidase N FZN67_06850 ENOG4107RYR Transcriptional regulator, Crp Fnr family FZN67_06855 ENOG4108UKZ OsmC family FZN67_06875 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) FZN67_06880 ENOG4105EW9 transcriptional regulator AsnC family FZN67_06895 ENOG4105R8C Transcriptional regulator FZN67_06905 ENOG4105CUY Mechanosensitive ion channel FZN67_06940 ENOG4105CNM Receptor FZN67_06960 ENOG4105C5H ABC transporter FZN67_06965 ENOG41081QV Universal stress protein FZN67_06980 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FZN67_06990 ENOG4105DKK Benzoate FZN67_06995 ENOG4105EW9 transcriptional regulator AsnC family FZN67_07000 ENOG4108NIW Leucine export protein LeuE FZN67_07005 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FZN67_07010 ENOG4105C5Q Transcriptional regulator FZN67_07020 ENOG4105CHU acetyl-coa acetyltransferase FZN67_07025 ENOG4105CHR reductase FZN67_07050 ENOG4107QMP dna polymerase iii subunits gamma and tau FZN67_07055 ENOG4105HSS phospholipase C FZN67_07065 ENOG4105C0A alcohol dehydrogenase FZN67_07095 ENOG4105CBC glutamate synthase FZN67_07395 ENOG4105UPP uncharacterized protein ydcA FZN67_07425 ENOG4105DR5 peptidase FZN67_07520 ENOG4105D8G Major Facilitator superfamily FZN67_07530 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FZN67_07535 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FZN67_07560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FZN67_07570 ENOG4107QZF nitrite reductase NADPH large subunit FZN67_07575 ENOG4108IFG nitrite reductase, (NAD(P)H) FZN67_07595 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FZN67_07610 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FZN67_07615 ENOG4105CVM Molybdenum cofactor synthesis domain protein FZN67_07625 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FZN67_07630 ENOG4105T38 integral membrane protein FZN67_07650 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FZN67_07655 ENOG4105CMR udp-glucose 4-epimerase FZN67_07730 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FZN67_07735 ENOG4105CUX Signal transduction histidine kinase FZN67_07760 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FZN67_07765 ENOG4105KNE Phosphatidate cytidylyltransferase FZN67_07775 ENOG4105DZP Membrane-associated zinc metalloprotease FZN67_07800 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FZN67_07815 ENOG4105Y3E Modulates RecA activity (By similarity) FZN67_07825 ENOG4105VEJ Heat shock protein FZN67_07830 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FZN67_07855 ENOG4105F7P transcriptional regulator AsnC family FZN67_07865 ENOG4105C85 amino acid FZN67_07880 ENOG4105CHH sulfate transporter FZN67_07885 ENOG4108RAV Conserved protein FZN67_07890 ENOG4105D8V Glucose sorbosone dehydrogenase FZN67_07900 ENOG4105BZU Histidine kinase FZN67_07920 ENOG4105DM4 PTS System FZN67_07925 ENOG4105DE4 1-phosphofructokinase FZN67_07930 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FZN67_07955 ENOG4105CWM branched-chain amino acid transport system II carrier protein FZN67_07960 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FZN67_07965 ENOG4105CC0 LysR family Transcriptional regulator FZN67_07975 ENOG4105M2J Glutaredoxin FZN67_07980 ENOG4105C8Y Acetylornithine aminotransferase FZN67_07985 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FZN67_08010 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FZN67_08020 ENOG41068P6 UPF0319 protein FZN67_08040 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FZN67_08045 ENOG4105C4M (Ubiquinol oxidase) subunit I FZN67_08055 ENOG4105PV3 Inner membrane protein yqiJ FZN67_08070 ENOG4105E0K tonB-dependent siderophore receptor FZN67_08080 ENOG4105HDD phospholipase FZN67_08085 ENOG4105CZN Potassium uptake protein FZN67_08095 ENOG4105C7B Threonine dehydratase FZN67_08125 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FZN67_08130 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FZN67_08140 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FZN67_08155 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FZN67_08200 ENOG4107VMU Membrane FZN67_08205 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FZN67_08215 ENOG4107QP7 CoA-transferase subunit A FZN67_08220 ENOG4107QNJ CoA-transferase subunit B FZN67_08225 ENOG4105CHU acetyl-coa acetyltransferase FZN67_08230 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FZN67_08235 ENOG4105F2Z 3-oxoadipate enol-lactonase FZN67_08240 ENOG4105D2S major facilitator superfamily FZN67_08245 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FZN67_08250 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta FZN67_08255 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha FZN67_08260 ENOG4105FF2 Type I DHQase FZN67_08265 ENOG4106JPM 3-dehydroshikimate dehydratase FZN67_08270 ENOG4105TW1 Carbohydrate-selective porin OprB FZN67_08275 ENOG4105DZG Dehydrogenase FZN67_08285 ENOG4105MD1 YeeE YedE family protein FZN67_08300 ENOG4107HP6 Transcriptional regulator FZN67_08305 ENOG4108PTX LysR family Transcriptional regulator FZN67_08310 ENOG4105C1G acyl-Coa dehydrogenase FZN67_08335 ENOG4105DNH Major Facilitator FZN67_08345 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FZN67_08365 ENOG4105FUY alpha subunit FZN67_08375 ENOG4105CHR reductase FZN67_08395 ENOG4105F11 amine oxidase FZN67_08405 ENOG4105C26 Dehydrogenase FZN67_08415 ENOG4105F2Z 3-oxoadipate enol-lactonase FZN67_08420 ENOG4105CHU acetyl-coa acetyltransferase FZN67_08425 ENOG4107QNJ CoA-transferase subunit B FZN67_08430 ENOG4107QP7 CoA-transferase subunit A FZN67_08440 ENOG4105NN7 muconolactone delta-isomerase FZN67_08445 ENOG4105DTQ mandelate racemase muconate lactonizing FZN67_08450 ENOG4108KB2 LysR family Transcriptional regulator FZN67_08460 ENOG4107EJG GntR family transcriptional regulator FZN67_08480 ENOG4105CZJ Aldehyde dehydrogenase FZN67_08500 ENOG4105C1G acyl-Coa dehydrogenase FZN67_08510 ENOG4108JU7 Transcriptional regulator FZN67_08520 ENOG41062QD Membrane FZN67_08535 ENOG4107RGH Aldehyde dehydrogenase FZN67_08550 ENOG4105CH6 catalase FZN67_08575 ENOG4105K56 Transcriptional regulator FZN67_08580 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FZN67_08590 ENOG4105NAE bifunctional deaminase-reductase domain protein FZN67_08620 ENOG4107Z3H Transcriptional regulator, TetR family FZN67_08630 ENOG4105CHJ isochorismatase hydrolase FZN67_08635 ENOG4105EJC lysr family transcriptional regulator FZN67_08640 ENOG4105D8V Glucose sorbosone dehydrogenase FZN67_08645 ENOG4105CKD glutathione-regulated potassium-efflux system protein FZN67_08655 ENOG4105CH2 amidohydrolase FZN67_08670 ENOG4105D5K Hemolysin activator protein FZN67_08675 ENOG4105CKT filamentous hemagglutinin FZN67_08705 ENOG4105FDP GntR family transcriptional regulator FZN67_08730 ENOG4106KR7 LysR family Transcriptional regulator FZN67_08755 ENOG4108JQ1 Dehydrogenase FZN67_08760 ENOG4105JSC dimethylmenaquinone methyltransferase FZN67_08780 ENOG4105CW7 secretion protein, HlyD family FZN67_08795 ENOG4105CZJ Aldehyde dehydrogenase FZN67_08800 ENOG4105C01 Dihydroxy-acid dehydratase FZN67_08810 ENOG4105DDW LysR family Transcriptional regulator FZN67_08815 ENOG4105EXW epimerase dehydratase FZN67_08825 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FZN67_08830 ENOG4105CF7 AraC family transcriptional regulator FZN67_08845 ENOG4105DQ4 alcohol dehydrogenase FZN67_08855 ENOG4105EHG Permease protein FZN67_08860 ENOG4105E0A ABC, transporter FZN67_08880 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FZN67_08960 ENOG4108UAJ Transcriptional regulator FZN67_09000 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FZN67_09055 ENOG4108BAS reductase FZN67_09070 ENOG4108R6W Transcriptional regulator, ARAC family FZN67_09075 ENOG4108821 RND type efflux pump FZN67_09080 ENOG4105E0F Histidine kinase FZN67_09085 ENOG4105E3W Two component transcriptional regulator (Winged helix family FZN67_09090 ENOG4105C1P efflux transporter, rnd family, mfp subunit FZN67_09095 ENOG4105BZS acriflavin resistance protein FZN67_09100 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FZN67_09110 ENOG4105CT3 Monooxygenase FZN67_09130 ENOG4105CJP fad dependent oxidoreductase FZN67_09150 ENOG4105X0I Fimbrial FZN67_09205 ENOG4107RZC phospholipase d FZN67_09225 ENOG4108IGT Dipeptidase FZN67_09260 ENOG4107T31 5'-nucleotidase FZN67_09270 ENOG4105WQI isochorismatase FZN67_09275 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FZN67_09280 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FZN67_09285 ENOG4105E0C molybdate abc transporter FZN67_09290 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FZN67_09295 ENOG4105F4R Transcriptional regulator mode FZN67_09300 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit FZN67_09305 ENOG4108YS2 small subunit FZN67_09310 ENOG4105F57 Anthranilate dioxygenase reductase FZN67_09335 ENOG4105CHR reductase FZN67_09345 ENOG4105D2S major facilitator superfamily FZN67_09350 ENOG4105CF7 AraC family transcriptional regulator FZN67_09360 ENOG4105DTD Dehydrogenase FZN67_09365 ENOG4105CY2 Citrate transporter FZN67_09375 ENOG4108M0I Transcriptional regulator FZN67_09385 ENOG4107QNJ CoA-transferase subunit B FZN67_09390 ENOG4105CRW Short chain fatty acid transporter FZN67_09395 ENOG4105CHU acetyl-coa acetyltransferase FZN67_09405 ENOG4107YNJ LysR family Transcriptional regulator FZN67_09420 ENOG4108IJ0 Aspartate ammonia-lyase FZN67_09430 ENOG4105CSH Transporter FZN67_09450 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FZN67_09455 ENOG4106FTQ Taurine ABC transporter, periplasmic FZN67_09470 ENOG4105FDP GntR family transcriptional regulator FZN67_09480 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FZN67_09485 ENOG4105KVH Transcriptional regulator FZN67_09490 ENOG4105UEI Transcriptional Regulator AraC Family FZN67_09505 ENOG4108VCT Sulfite exporter TauE/SafE FZN67_09515 ENOG4107QPB Beta-lactamase domain protein FZN67_09525 ENOG4105FFC UPF0187 protein FZN67_09535 ENOG4105CHR reductase FZN67_09550 ENOG4105CPP Dehydrogenase, E1 component FZN67_09555 ENOG4107R0V Pyruvate dehydrogenase FZN67_09560 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FZN67_09575 ENOG4105BZU Histidine kinase FZN67_09585 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FZN67_09590 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FZN67_09635 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FZN67_09650 ENOG4105C28 cystathionine FZN67_09660 ENOG4105F2W methyltransferase FZN67_09690 ENOG4105K59 histidine triad (HIT) protein FZN67_09715 ENOG4107QWP ABC-2 type transporter FZN67_09720 ENOG4107QWP ABC-2 type transporter FZN67_09725 ENOG4105CJ1 ABC, transporter FZN67_09740 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FZN67_09745 ENOG4105CNM Receptor FZN67_09765 ENOG4107TSN permease FZN67_09770 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FZN67_09790 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FZN67_09795 ENOG4108YZT Adenosylcobinamide kinase FZN67_09850 ENOG4105DJU Siderophore biosynthesis protein FZN67_09855 ENOG4105DUU IucA IucC family protein FZN67_09875 ENOG4108Z66 YbaK ebsC protein FZN67_09890 ENOG4105C1G acyl-Coa dehydrogenase FZN67_09895 ENOG4105C1G acyl-Coa dehydrogenase FZN67_09900 ENOG4105EEF Alkane 1-monooxygenase FZN67_09905 ENOG4105E7U AraC family transcriptional regulator FZN67_09910 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FZN67_09915 ENOG4105K70 DNA-binding protein FZN67_09930 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FZN67_09940 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FZN67_09945 ENOG4108Z4V iron-sulfur cluster assembly FZN67_09960 ENOG4108ZIT Ferredoxin, 2FE-2S FZN67_09965 ENOG4105F8J Adenylate Guanylate cyclase FZN67_09975 ENOG4108JA2 transcriptioN-repair coupling factor FZN67_09995 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FZN67_10000 ENOG4105K4T epimerase FZN67_10015 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FZN67_10035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FZN67_10045 ENOG4105DGW oligopeptidase A FZN67_10085 ENOG4105SG9 biopolymer transport protein, ExbD FZN67_10095 ENOG4107QP3 malate synthase g FZN67_10100 ENOG4105D6Z AFG1 family ATPase FZN67_10110 ENOG4107RN6 Monooxygenase FZN67_10130 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FZN67_10135 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FZN67_10150 ENOG4108Z6B deaminase FZN67_10170 ENOG4108RTD type II secretion system protein K FZN67_10195 ENOG4105F8V Hydrolase, tatD family FZN67_10205 ENOG4107QRG dna polymerase iii FZN67_10215 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FZN67_10220 ENOG4105BZ1 (ABC) transporter FZN67_10235 ENOG4105FA0 parb-like partition protein FZN67_10240 ENOG4107QJE Chromosome Partitioning Protein FZN67_10250 ENOG4108S0S Nucleotidyl transferase FZN67_10255 ENOG4105EHM Aminoglycoside phosphotransferase FZN67_10260 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FZN67_10265 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FZN67_10270 ENOG4105D2N Aldolase FZN67_10290 ENOG4108UHJ MAF-like protein FZN67_10295 ENOG4105EZE Cupin 4 family protein FZN67_10305 ENOG41080HT Transcriptional regulator, arsr family FZN67_10315 ENOG4105XPP Protein of unknown function (DUF1275) FZN67_10320 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FZN67_10325 ENOG4105BZ1 (ABC) transporter FZN67_10335 ENOG4108ZX5 transcriptional regulator FZN67_10345 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FZN67_10350 ENOG4105CK7 Sodium proline symporter FZN67_10355 ENOG4105EW9 transcriptional regulator AsnC family FZN67_10360 ENOG4105C26 Dehydrogenase FZN67_10365 ENOG4105YGK Pfam:UPF0157 FZN67_10380 ENOG4108T58 Mg2 transport protein CorA FZN67_10390 ENOG4107RYR Transcriptional regulator, Crp Fnr family FZN67_10395 ENOG4108UKZ OsmC family FZN67_10410 ENOG4108YYC ycei family FZN67_10420 ENOG4105CV1 Transketolase (EC 2.2.1.1) FZN67_10445 ENOG4108HWY Beta-lactamase FZN67_10465 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FZN67_10470 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FZN67_10490 ENOG4105X0I Fimbrial FZN67_10495 ENOG4105GQR Chaperone FZN67_10525 ENOG4108IPJ Membrane FZN67_10535 ENOG4105ETS cytosine purines uracil thiamine allantoin FZN67_10545 ENOG4105CC0 LysR family Transcriptional regulator FZN67_10565 ENOG41067SE Tetr family transcriptional regulator FZN67_10580 ENOG4105EW9 transcriptional regulator AsnC family FZN67_10590 ENOG4105CDA abc transporter atp-binding protein FZN67_10595 ENOG4105DRP amino acid AbC transporter FZN67_10600 ENOG4105EAD ABC transporter FZN67_10615 ENOG4107T8P acyl-Coa dehydrogenase FZN67_10630 ENOG4105D01 (LipO)protein FZN67_10635 ENOG4105D01 (LipO)protein FZN67_10640 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FZN67_10645 ENOG4108UMI ABC transporter, permease FZN67_10650 ENOG4105C3G gtp-binding protein FZN67_10675 ENOG4108UMN azlc family FZN67_10680 ENOG4105ZED uncharacterized protein ygaH FZN67_10710 ENOG4105E7U AraC family transcriptional regulator FZN67_10715 ENOG4108V06 Glutathione peroxidase FZN67_10725 ENOG4105CHM Aminotransferase FZN67_10740 ENOG4105C0B DNA polymerase III (alpha subunit) FZN67_10765 ENOG4108JU3 Alkyl hydroperoxide reductase FZN67_10780 ENOG4108KB2 LysR family Transcriptional regulator FZN67_10785 ENOG4105D6J arsenicaL-resistance protein FZN67_10790 ENOG41082YX Transcriptional regulator, arsr family FZN67_10805 ENOG4105CPN adenine deaminase FZN67_10815 ENOG4105CBN LysR family transcriptional regulator FZN67_10825 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FZN67_10835 ENOG4105E2B Taurine dioxygenase FZN67_10840 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FZN67_10845 ENOG4108IY8 ABC, transporter FZN67_10850 ENOG4106FTQ Taurine ABC transporter, periplasmic FZN67_10860 ENOG4105C54 Major Facilitator superfamily FZN67_10885 ENOG4105C4M (Ubiquinol oxidase) subunit I FZN67_10890 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FZN67_10900 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FZN67_10905 ENOG4108K70 Transcriptional regulator FZN67_10920 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FZN67_10925 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase FZN67_10940 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) FZN67_10945 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FZN67_10955 ENOG4105DXI Major Facilitator superfamily FZN67_10975 ENOG41067MG lrgb family FZN67_10980 ENOG4105VAW lrga family FZN67_10985 ENOG4105CMU LysR family (Transcriptional regulator FZN67_10990 ENOG4108SHQ Glutathione S-transferase FZN67_10995 ENOG4105CYM Glutathione S-transferase FZN67_11000 ENOG4105CBN LysR family transcriptional regulator FZN67_11005 ENOG4105CHR reductase FZN67_11015 ENOG4105D7W serine acetyltransferase FZN67_11020 ENOG4105ESN nucleotide-binding protein FZN67_11025 ENOG4105C9B Cysteine desulfurase FZN67_11040 ENOG4105EXG Transcriptional regulator FZN67_11050 ENOG4105CT1 (ABC) transporter FZN67_11055 ENOG4107RP9 extracellular solute-binding protein, family 3 FZN67_11060 ENOG4105CDA abc transporter atp-binding protein FZN67_11065 ENOG4108HW4 amino acid AbC transporter FZN67_11070 ENOG4105EAD ABC transporter FZN67_11085 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FZN67_11090 ENOG4105BZU Histidine kinase FZN67_11100 ENOG4105EW9 transcriptional regulator AsnC family FZN67_11110 ENOG4105KT5 UmuD protein FZN67_11130 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FZN67_11175 ENOG4105HEI LysR family (Transcriptional regulator FZN67_11195 ENOG4105CEY Amp-dependent synthetase and ligase FZN67_11200 ENOG4105R8C Transcriptional regulator FZN67_11205 ENOG4105C1G acyl-Coa dehydrogenase FZN67_11210 ENOG4107QX3 carboxylase FZN67_11215 ENOG4105E39 Enoyl-CoA hydratase FZN67_11230 ENOG4105CC0 LysR family Transcriptional regulator FZN67_11245 ENOG4105CSU acyl-Coa dehydrogenase FZN67_11255 ENOG4105EQ0 Major Facilitator superfamily FZN67_11265 ENOG4107QNJ CoA-transferase subunit B FZN67_11270 ENOG4107QP7 CoA-transferase subunit A FZN67_11275 ENOG4107RGD Major Facilitator superfamily FZN67_11280 ENOG4105C1G acyl-Coa dehydrogenase FZN67_11285 ENOG4105E39 Enoyl-CoA hydratase FZN67_11290 ENOG4105CHR reductase FZN67_11295 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FZN67_11300 ENOG4105CHU acetyl-coa acetyltransferase FZN67_11310 ENOG4105EQ0 Major Facilitator superfamily FZN67_11315 ENOG4105EA8 2-Nitropropane dioxygenase FZN67_11320 ENOG4108UKI Enoyl-CoA hydratase FZN67_11335 ENOG4105C1G acyl-Coa dehydrogenase FZN67_11340 ENOG4107RGD Major Facilitator superfamily FZN67_11345 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FZN67_11350 ENOG4107STF Involved in phosphonate degradation (By similarity) FZN67_11360 ENOG4107RCV ABC transporter, permease FZN67_11365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FZN67_11370 ENOG4105C4Y ABC transporter FZN67_11380 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase FZN67_11385 ENOG4107HP6 Transcriptional regulator FZN67_11395 ENOG4105HEI LysR family (Transcriptional regulator FZN67_11400 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FZN67_11405 ENOG4105C26 Dehydrogenase FZN67_11415 ENOG4105ETS cytosine purines uracil thiamine allantoin FZN67_11425 ENOG4105C26 Dehydrogenase FZN67_11430 ENOG4108M8W Monooxygenase FZN67_11435 ENOG4105MXW flavin reductase domain protein, FMN-binding FZN67_11440 ENOG4108MXF Alpha Beta Hydrolase FZN67_11460 ENOG4105CPW cytochrome b561 FZN67_11465 ENOG4107VGR Catalase FZN67_11505 ENOG4107YAU phenylacetic acid degradation protein FZN67_11515 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FZN67_11520 ENOG4105DZS Phenylacetate-CoA ligase FZN67_11525 ENOG4105CHU acetyl-coa acetyltransferase FZN67_11530 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FZN67_11535 ENOG4108UKI Enoyl-CoA hydratase FZN67_11540 ENOG4105E39 Enoyl-CoA hydratase FZN67_11545 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FZN67_11550 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FZN67_11555 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FZN67_11560 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FZN67_11565 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FZN67_11570 ENOG4105DXM phenylacetic acid degradation protein FZN67_11575 ENOG4105EJQ L-serine dehydratase FZN67_11580 ENOG4107QTZ amino acid FZN67_11585 ENOG4105CZJ Aldehyde dehydrogenase FZN67_11610 ENOG4105MWK D-amino acid dehydrogenase, small subunit FZN67_11630 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FZN67_11645 ENOG4108Z4X TRANSCRIPTIONal FZN67_11660 ENOG4105WPN DNA integration recombination invertion protein FZN67_11675 ENOG4105DJ2 Major Facilitator Superfamily FZN67_11680 ENOG4107Y2X deaminase FZN67_11690 ENOG4105EMY transcriptional regulator FZN67_11725 ENOG4107RYR Transcriptional regulator, Crp Fnr family FZN67_11730 ENOG4108UKZ OsmC family FZN67_11750 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FZN67_11760 ENOG4105UYK outer membrane protein a FZN67_11835 ENOG4108HW3 (ABC) transporter FZN67_11845 ENOG4105MRR Transcriptional regulator (By similarity) FZN67_11865 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF FZN67_11870 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FZN67_11885 ENOG4105E2A Dehydrogenase FZN67_11895 ENOG4105R8C Transcriptional regulator FZN67_11920 ENOG4107R4J Chloride channel FZN67_11925 ENOG4108JIK carboxylase FZN67_11945 ENOG4105C5A transporter FZN67_11950 ENOG4108WAV Transcriptional regulator FZN67_11965 ENOG4105CNA YD repeat protein FZN67_12005 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FZN67_12025 ENOG4105D2S major facilitator superfamily FZN67_12040 ENOG4105D1S lipid A biosynthesis FZN67_12045 ENOG4105BZU Histidine kinase FZN67_12050 ENOG4107AQZ Membrane FZN67_12070 ENOG4108Z4U Ferredoxin FZN67_12110 ENOG4105DFG type I secretion outer membrane protein FZN67_12115 ENOG4108IUZ ABC transporter FZN67_12120 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FZN67_12130 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FZN67_12135 ENOG4105C2X Arabinose 5-phosphate isomerase FZN67_12170 ENOG4107YPT transcriptional regulator FZN67_12205 ENOG4105II7 pyrroline-5-carboxylate reductase FZN67_12215 ENOG4105VEQ Cold shock protein FZN67_12220 ENOG410829K Lysine exporter protein (Lyse ygga) FZN67_12255 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FZN67_12310 ENOG4108KB2 LysR family Transcriptional regulator FZN67_12315 ENOG4105FUY alpha subunit FZN67_12320 ENOG4108UKV benzoate 1,2-dioxygenase FZN67_12325 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein FZN67_12330 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase FZN67_12335 ENOG4105DKK Benzoate FZN67_12340 ENOG4105D2S major facilitator superfamily FZN67_12355 ENOG4105CQ7 ATP-dependent helicase FZN67_12360 ENOG4105D3R alkyl hydroperoxide reductase FZN67_12370 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FZN67_12380 ENOG4108JU3 Alkyl hydroperoxide reductase FZN67_12390 ENOG4108K3A Glutathione S-transferase FZN67_12400 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FZN67_12405 ENOG4108TGY Glutathione S-transferase FZN67_12415 ENOG4108ZG0 Ompa motb domain protein FZN67_12420 ENOG4105CD3 dihydroorotase FZN67_12450 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FZN67_12470 ENOG4108UKZ OsmC family FZN67_12475 ENOG4107RYR Transcriptional regulator, Crp Fnr family FZN67_12485 ENOG4105CPC Aldo Keto reductase FZN67_12500 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FZN67_12510 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FZN67_12520 ENOG4105CFH Aspartokinase FZN67_12530 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FZN67_12540 ENOG4105CPW cytochrome b561 FZN67_12545 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FZN67_12550 ENOG4105C7N Xanthine uracil vitamin C permease FZN67_12560 ENOG4105F95 Monooxygenase FZN67_12640 ENOG4108C33 Resolvase FZN67_12680 ENOG4105C85 amino acid FZN67_12700 ENOG4105C26 Dehydrogenase FZN67_12720 ENOG4105CUB amino acid FZN67_12730 ENOG4105C85 amino acid FZN67_12775 ENOG4105CNA YD repeat protein FZN67_12795 ENOG4105D01 (LipO)protein FZN67_12800 ENOG4108M3P Membrane FZN67_12815 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FZN67_12835 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FZN67_12855 ENOG4108JQ5 ABC transporter FZN67_12860 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FZN67_12865 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FZN67_12875 ENOG4105E9H Lytic Murein transglycosylase FZN67_12875 ENOG4105E9H Lytic Murein transglycosylase FZN67_12880 ENOG4107RZZ dna polymerase iii epsilon subunit FZN67_12890 ENOG4105E09 nadh pyrophosphatase FZN67_12900 ENOG4105W4M Transport-associated protein FZN67_12910 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FZN67_12920 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FZN67_12925 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FZN67_12945 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FZN67_12950 ENOG4105D0A hydroxylase FZN67_12955 ENOG4107RAQ aminopeptidase FZN67_12990 ENOG4105DIJ Phosphoethanolamine transferase FZN67_13035 ENOG4105DR5 peptidase FZN67_13360 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FZN67_13385 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FZN67_13395 ENOG4105D82 Glutamate dehydrogenase FZN67_13400 ENOG4108R3D Electron transport complex FZN67_13405 ENOG4105CSM endonuclease III FZN67_13430 ENOG4105CJN penicillin-binding protein FZN67_13435 ENOG4106H78 methyltransferase FZN67_13450 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FZN67_13460 ENOG4105CQM Urea amidohydrolase subunit alpha FZN67_13490 ENOG4107RET Isocitrate lyase FZN67_13500 ENOG4105C37 (CBS) domain FZN67_13510 ENOG4105D4T Citrate transporter FZN67_13525 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FZN67_13540 ENOG4108MRJ FZN67_13560 ENOG4105VCQ rubredoxin FZN67_13565 ENOG4107QZF nitrite reductase NADPH large subunit FZN67_13575 ENOG4105C5Q Transcriptional regulator FZN67_13595 ENOG4107U91 Rhomboid family FZN67_13600 ENOG4105CV6 ABC transporter, permease FZN67_13605 ENOG4108I0Y (ABC) transporter FZN67_13610 ENOG4108UJV acyl-CoA thioesterase i FZN67_13630 ENOG4107RNH Outer membrane receptor FepA FZN67_13645 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FZN67_13650 ENOG4105E6M Sulphatase-modifying factor protein FZN67_13670 ENOG4105CJ3 phosphate transporter FZN67_13675 ENOG4105C3R Methionine synthase FZN67_13690 ENOG4105CSP Major Facilitator Superfamily FZN67_13700 ENOG4108PZW LysR family Transcriptional regulator FZN67_13715 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FZN67_13720 ENOG4105EU0 Major facilitator Superfamily FZN67_13725 ENOG4108R6W Transcriptional regulator, ARAC family FZN67_13730 ENOG4105CSV Glutaminase FZN67_13735 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FZN67_13740 ENOG4105CSH Transporter FZN67_13750 ENOG4105C7K acetolactate synthase FZN67_13765 ENOG4105CHR reductase FZN67_13770 ENOG4108MXF Alpha Beta Hydrolase FZN67_13780 ENOG4105DJB Major Facilitator Superfamily FZN67_13785 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase FZN67_13795 ENOG4105CHR reductase FZN67_13815 ENOG41069M3 Transcriptional regulator FZN67_13830 ENOG4106YT9 Enoyl-CoA hydratase FZN67_13840 ENOG4105CND Glycosyl transferase, family 2 FZN67_13845 ENOG4107BJW polysaccharide deacetylase FZN67_13855 ENOG4108VWS Yaeq family FZN67_13865 ENOG4105CKI cobalamin synthesis protein FZN67_13885 ENOG4105C94 Transporter FZN67_13890 ENOG4105C94 Transporter FZN67_13895 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FZN67_13920 ENOG4107QK5 Homocysteine s-methyltransferase FZN67_13925 ENOG4105D5Q Arginine ornithine antiporter FZN67_13950 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FZN67_13955 ENOG4105C54 Major Facilitator superfamily FZN67_14075 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FZN67_14115 ENOG4105K4U addiction module toxin, RelE StbE family FZN67_14265 ENOG4105VTN Protein of unknown function (DUF1311) FZN67_14400 ENOG41083X2 DNA polymerase III, epsilon subunit FZN67_14465 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FZN67_14470 ENOG4105C0R drug resistance transporter emrb qaca subfamily FZN67_14475 ENOG4105CW7 secretion protein, HlyD family FZN67_14480 ENOG4108VUY thioesterase Superfamily protein FZN67_14485 ENOG4105D52 delta-aminolevulinic acid dehydratase FZN67_14490 ENOG4105MWK D-amino acid dehydrogenase, small subunit FZN67_14495 ENOG4105ECP epimerase FZN67_14515 ENOG4107RH8 nuclease SbcCD subunit D FZN67_14520 ENOG4105EYH Exonuclease FZN67_14525 ENOG4105DFA alanine racemase domain protein FZN67_14530 ENOG4105CZX twitching motility protein FZN67_14535 ENOG4105CZX twitching motility protein FZN67_14540 ENOG41090R7 Ferric uptake FZN67_14570 ENOG4105E7A Glutamine amidotransferase FZN67_14585 ENOG4107QKV phosphomannomutase FZN67_14595 ENOG4105C4R Atp-dependent dna helicase FZN67_14600 ENOG4108ZG0 Ompa motb domain protein FZN67_14605 ENOG4106HNH Acyl-transferase FZN67_14620 ENOG4107QMS site-determining protein FZN67_14650 ENOG4105CNU cell division protein FtsK FZN67_14655 ENOG4105C3M thioredoxin reductase FZN67_14660 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FZN67_14670 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FZN67_14715 ENOG4108YXA Membrane FZN67_14720 ENOG4105EUB pirin domain protein FZN67_14730 ENOG4105C4K Nad synthetase FZN67_14745 ENOG4105E3J oxidoreductase FZN67_14750 ENOG4105C26 Dehydrogenase FZN67_14755 ENOG4105DVW rieske (2Fe-2S) FZN67_14765 ENOG4105C94 Transporter FZN67_14770 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FZN67_14775 ENOG4105EJC lysr family transcriptional regulator FZN67_14795 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FZN67_14815 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FZN67_14820 ENOG4105C34 Pseudouridine synthase FZN67_14825 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FZN67_14830 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FZN67_14845 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) FZN67_14875 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FZN67_14905 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FZN67_14915 ENOG4105DWF phosphomethylpyrimidine kinase FZN67_14920 ENOG4109066 lysm domain bon superfamily protein FZN67_14930 ENOG4105CHR reductase FZN67_14935 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FZN67_14945 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FZN67_14950 ENOG4108BPE -transporting atpase FZN67_14955 ENOG4107RTD sua5 ycio yrdc ywlc family protein FZN67_14960 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FZN67_14965 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FZN67_14970 ENOG4105FE9 pseudouridine synthase FZN67_14980 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FZN67_14985 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FZN67_14995 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FZN67_15000 ENOG4108K4C ec 3.1.3.12 FZN67_15005 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FZN67_15010 ENOG4106UW1 Major Facilitator superfamily FZN67_15030 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FZN67_15040 ENOG4105HF0 Membrane FZN67_15055 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FZN67_15065 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FZN67_15125 ENOG4105D1F ATP-binding protein FZN67_15135 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FZN67_15165 ENOG4105K6H D-cysteine desulfhydrase FZN67_15170 ENOG4105CBX hi0933 family FZN67_15195 ENOG4105DP0 ferredoxin-NADP reductase FZN67_15200 ENOG4105DUM transcriptional regulator, lysR family FZN67_15220 ENOG4105C8S subunit m FZN67_15225 ENOG4105D65 subunit l FZN67_15235 ENOG4107UFS subunit j FZN67_15250 ENOG4108IEH NADH dehydrogenase subunit g FZN67_15255 ENOG4107QIZ NADH dehydrogenase FZN67_15260 ENOG4105GKE subunit e FZN67_15280 ENOG4105BZU Histidine kinase FZN67_15290 ENOG4105E0F Histidine kinase FZN67_15295 ENOG4107EXC regulatoR FZN67_15305 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FZN67_15315 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FZN67_15325 ENOG4105EB3 Histidine kinase FZN67_15395 ENOG4105DZG Dehydrogenase FZN67_15415 ENOG4105JAB phenazine biosynthesis protein, phzf family FZN67_15445 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FZN67_15450 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FZN67_15460 ENOG4105ETT transcriptional Regulator, LysR family FZN67_15480 ENOG4105CH2 amidohydrolase FZN67_15490 ENOG4106P55 Transcriptional regulator FZN67_15510 ENOG4106P55 Transcriptional regulator FZN67_15515 ENOG4107EFR Flavocytochrome c FZN67_15525 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FZN67_15530 ENOG4107RGD Major Facilitator superfamily FZN67_15535 ENOG4105C1G acyl-Coa dehydrogenase FZN67_15540 ENOG4105ETT transcriptional Regulator, LysR family FZN67_15575 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FZN67_15580 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FZN67_15585 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FZN67_15600 ENOG4105VR0 copper resistance FZN67_15605 ENOG4105E3B Multicopper oxidase FZN67_15615 ENOG4108HCJ Hydrolase FZN67_15620 ENOG4105DJV ribulose-phosphate 3-epimerase FZN67_15645 ENOG41072GX Peptidase M22 Glycoprotease FZN67_15650 ENOG4108Z0R Transferase FZN67_15705 ENOG4105CRQ synthase (Component I) FZN67_15715 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FZN67_15720 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FZN67_15725 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FZN67_15795 ENOG4105K56 Transcriptional regulator FZN67_15800 ENOG4108ZHJ Organic hydroperoxide resistance protein FZN67_15805 ENOG4107QHF type ii secretion system protein e FZN67_15825 ENOG4105C2M dna polymerase I FZN67_15830 ENOG4108VIA integral membrane protein FZN67_15835 ENOG4105II7 pyrroline-5-carboxylate reductase FZN67_15840 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FZN67_15850 ENOG4105C9X ppx gppa phosphatase FZN67_15860 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FZN67_15880 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FZN67_15905 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FZN67_15920 ENOG4105W39 Membrane FZN67_15925 ENOG4105CYM Glutathione S-transferase FZN67_15945 ENOG4105CEY Amp-dependent synthetase and ligase FZN67_15950 ENOG4105N42 UPF0307 protein FZN67_15955 ENOG41080Z8 PHOSPHOCARRIER protein FZN67_15975 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FZN67_15980 ENOG4105DJ0 Poly(A) Polymerase FZN67_15985 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FZN67_15990 ENOG4105DXN mazG family FZN67_16000 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FZN67_16015 ENOG4105C6T cysteine synthase FZN67_16020 ENOG4105BZU Histidine kinase FZN67_16025 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase FZN67_16030 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FZN67_16035 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FZN67_16050 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FZN67_16055 ENOG4105W8H transhydrogenase (subunit alpha FZN67_16060 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FZN67_16065 ENOG4106UX7 integral membrane protein FZN67_16080 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FZN67_16090 ENOG4107RSM transcriptional regulator FZN67_16100 ENOG4105CUZ uba thif-type nad fad binding protein FZN67_16110 ENOG4107QM5 aconitate hydratase FZN67_16115 ENOG4105F8V Hydrolase, tatD family FZN67_16130 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FZN67_16155 ENOG4105BZU Histidine kinase FZN67_16165 ENOG4108ZP8 Acetolactate synthase small subunit FZN67_16170 ENOG4105C7K acetolactate synthase FZN67_16195 ENOG4105DJY efflux transporter, rnd family, mfp subunit FZN67_16200 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FZN67_16205 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FZN67_16210 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FZN67_16220 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FZN67_16225 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FZN67_16235 ENOG4105VW4 glutaredoxin 3 FZN67_16255 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FZN67_16260 ENOG4105C2D reductase FZN67_16270 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FZN67_16300 ENOG4105C84 Histidine ammonia-lyase FZN67_16315 ENOG4105CEY Amp-dependent synthetase and ligase FZN67_16330 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FZN67_16350 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FZN67_16370 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) FZN67_16390 ENOG4105WVQ Fe-S assembly protein IscX FZN67_16405 ENOG4105CN1 protease FZN67_16420 ENOG4106HB6 Alpha beta hydrolase FZN67_16430 ENOG4105C26 Dehydrogenase FZN67_16435 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FZN67_16440 ENOG4105C6Z Gluconate FZN67_16445 ENOG4108UHU Aldolase FZN67_16450 ENOG4105C01 Dihydroxy-acid dehydratase FZN67_16455 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FZN67_16460 ENOG4108DNC Involved in acetate metabolism (By similarity) FZN67_16465 ENOG4107GFK fumarate FZN67_16485 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FZN67_16495 ENOG4108ESX Receptor FZN67_16505 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FZN67_16515 ENOG4105DWV Homoserine O-trans-acetylase FZN67_16615 ENOG4105CIY formyltetrahydrofolate deformylase FZN67_16625 ENOG4107RGH Aldehyde dehydrogenase FZN67_16630 ENOG4105KDC 50s ribosomal protein l28 FZN67_16635 ENOG4105W0E 50S ribosomal protein L33 FZN67_16640 ENOG4105CKD glutathione-regulated potassium-efflux system protein FZN67_16660 ENOG4105VFU Rna-binding protein FZN67_16665 ENOG4105C4R Atp-dependent dna helicase FZN67_16680 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FZN67_16690 ENOG4105KVH Transcriptional regulator FZN67_16700 ENOG41069P5 Protein slyX homolog FZN67_16705 ENOG4105C5H ABC transporter FZN67_16710 ENOG4105N14 lysine exporter protein LysE YggA FZN67_16715 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FZN67_16725 ENOG4105CK2 sodium dicarboxylate symporter FZN67_16780 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FZN67_16805 ENOG4105DUM transcriptional regulator, lysR family FZN67_16830 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FZN67_16845 ENOG4108W5M transcriptional regulator FZN67_16860 ENOG4105D29 Helix-turn-helix type 11 domain protein FZN67_16865 ENOG4107XGZ Hydrolase FZN67_16870 ENOG4105EI2 Pseudouridine synthase FZN67_16880 ENOG4105C03 ribonuclease FZN67_16900 ENOG4105CBN LysR family transcriptional regulator FZN67_16905 ENOG4105EMU Dehydrogenase FZN67_16910 ENOG4105CSA Coproporphyrinogen iii oxidase FZN67_16920 ENOG4107QI1 Mate efflux family protein FZN67_16930 ENOG4107T8P acyl-Coa dehydrogenase FZN67_16975 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FZN67_16980 ENOG4105C5X domain protein FZN67_16995 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FZN67_17005 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FZN67_17010 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FZN67_17015 ENOG4108JU5 Magnesium and cobalt efflux protein FZN67_17020 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FZN67_17025 ENOG4108Z7R Chaperone CsaA FZN67_17035 ENOG4108VAU general secretion pathway protein G FZN67_17040 ENOG4105D7Q type ii secretion system FZN67_17045 ENOG4105C25 Primosomal protein n' FZN67_17050 ENOG4105CKD glutathione-regulated potassium-efflux system protein FZN67_17055 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FZN67_17065 ENOG4105DVC DnaJ domain protein FZN67_17070 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) FZN67_17075 ENOG4107QUT magnesium and cobalt transport protein CorA FZN67_17095 ENOG4107QYX exodeoxyribonuclease v alpha FZN67_17100 ENOG4107QKA exodeoxyribonuclease V beta FZN67_17105 ENOG4105DSY exodeoxyribonuclease V, gamma FZN67_17115 ENOG4105CSR polyphosphate kinase 2 FZN67_17125 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FZN67_17140 ENOG41061H0 Monooxygenase FZN67_17145 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FZN67_17160 ENOG4105D65 subunit l FZN67_17165 ENOG4108ZE9 Monovalent cation H antiporter subunit C FZN67_17170 ENOG4107R4Z monovalent cation h antiporter subunit d FZN67_17175 ENOG4105SC1 monovalent cation H antiporter subunit E FZN67_17180 ENOG4105W4C monovalent cation H antiporter subunit F FZN67_17185 ENOG4105KJM monovalent cation h antiporter subunit g FZN67_17200 ENOG4105CHV Transcription elongation factor NusA FZN67_17225 ENOG4107EJC Preprotein translocase subunit SecG FZN67_17235 ENOG4107QHF type ii secretion system protein e FZN67_17250 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FZN67_17260 ENOG4105C2N RNA methyltransferase TrmH family group 3 FZN67_17275 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FZN67_17285 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FZN67_17315 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FZN67_17320 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FZN67_17390 ENOG4107ZXU DSBA oxidoreductase FZN67_17405 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FZN67_17420 ENOG4105D3Y Na H antiporter FZN67_17425 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FZN67_17475 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FZN67_17480 ENOG4105PM1 preprotein translocase subunit SecE FZN67_17520 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FZN67_17525 ENOG4105TV9 FHA Domain-Containing protein FZN67_17530 ENOG4105GVR general secretion pathway protein D FZN67_17545 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS FZN67_17570 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FZN67_17575 ENOG4108NEV two component transcriptional regulator, LytTR family FZN67_17580 ENOG4108HRK Histidine kinase FZN67_17595 ENOG4108UTW Plays a role in the regulation of phosphate uptake FZN67_17600 ENOG4105DFG type I secretion outer membrane protein FZN67_17605 ENOG4108RNG Permease of the drug metabolite transporter FZN67_17630 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FZN67_17635 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FZN67_17640 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FZN67_17645 ENOG4105CNI cell division protein FtsW FZN67_17660 ENOG4105CE1 Ferrous iron transport protein b FZN67_17670 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FZN67_17675 ENOG4105T95 Thiol disulfide interChange protein FZN67_17680 ENOG4105D6E homoserine dehydrogenase FZN67_17690 ENOG41061WM D-Alanyl-D-Alanine FZN67_17700 ENOG4107TUY Histidine kinase FZN67_17705 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FZN67_17710 ENOG4105CN1 protease FZN67_17715 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FZN67_17720 ENOG4108K5H permease YjgP YjgQ family protein FZN67_17760 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FZN67_17770 ENOG4105BZU Histidine kinase FZN67_17785 ENOG4105C0P Mg chelatase subunit ChlI FZN67_17795 ENOG4108R0M Aminoglycoside FZN67_17840 ENOG4105CHH sulfate transporter FZN67_17875 ENOG4105C0P Mg chelatase subunit ChlI FZN67_17880 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FZN67_17890 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FZN67_17900 ENOG4105EPF Outer membrane porin FZN67_17905 ENOG4105F0N pyrophosphate phospho-hydrolase FZN67_17920 ENOG4105CEY Amp-dependent synthetase and ligase FZN67_17925 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FZN67_17930 ENOG41079KZ Major Facilitator Superfamily FZN67_17935 ENOG4105EN6 Membrane FZN67_17945 ENOG4105EE5 Membrane protein terC FZN67_17950 ENOG4108URH decarboxylase FZN67_17965 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FZN67_17980 ENOG4105CCT upf0313 protein FZN67_18000 ENOG4105CS1 NAD(P)H quinone oxidoreductase FZN67_18010 ENOG4105C6T cysteine synthase FZN67_18045 ENOG4105Y7M Transcriptional regulator, TetR family FZN67_18080 ENOG4105C79 DNA protecting protein DprA FZN67_18095 ENOG4108IND Tetr family transcriptional regulator FZN67_18100 ENOG4107RTG Major Facilitator superfamily FZN67_18110 ENOG4108V06 Glutathione peroxidase FZN67_18150 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FZN67_18175 ENOG4105FDK ABC transporter FZN67_18180 ENOG4105FAV ABC, transporter FZN67_18190 ENOG4105EZR dyp-type peroxidase family protein FZN67_18200 ENOG4107R1I NAD-dependent malic enzyme FZN67_18225 ENOG4105EUB pirin domain protein FZN67_18245 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FZN67_18250 ENOG4106MP8 UPF0754 membrane protein FZN67_18255 ENOG4108VBZ doxx family FZN67_18260 ENOG4105DQR SNARE associated Golgi FZN67_18275 ENOG4107QJE Chromosome Partitioning Protein FZN67_18285 ENOG4107PSF BolA-like protein FZN67_18305 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FZN67_18330 ENOG4105C1G acyl-Coa dehydrogenase FZN67_18355 ENOG4105CSH Transporter FZN67_18360 ENOG4105E39 Enoyl-CoA hydratase FZN67_18365 ENOG4105E39 Enoyl-CoA hydratase FZN67_18370 ENOG4105C1G acyl-Coa dehydrogenase FZN67_18380 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FZN67_18385 ENOG4105C26 Dehydrogenase FZN67_18395 ENOG4105C85 amino acid FZN67_18400 ENOG4105C85 amino acid FZN67_18405 ENOG4105M4H endoribonuclease L-psp FZN67_18420 ENOG4105EW9 transcriptional regulator AsnC family FZN67_18445 ENOG4105D3G Pseudouridine synthase FZN67_18460 ENOG4108IG5 Transcriptional regulator FZN67_18510 ENOG4108I0Z Aconitate hydratase FZN67_18515 ENOG4105BZN citrate synthase FZN67_18520 ENOG4105CR4 methylisocitrate lyase FZN67_18525 ENOG4105DRR Transcriptional regulator, GntR family FZN67_18535 ENOG4105CGF Aromatic amino acid aminotransferase FZN67_18540 ENOG4105CXG d-lactate dehydrogenase FZN67_18550 ENOG41073TP transcriptional regulator FZN67_18555 ENOG4105DAA L-lactate FZN67_18560 ENOG4107QKV phosphomannomutase FZN67_18565 ENOG4105CMR udp-glucose 4-epimerase FZN67_18575 ENOG4105C6Y Udp-glucose 6-dehydrogenase FZN67_18580 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FZN67_18585 ENOG4105D3Q Sugar transferase FZN67_18590 ENOG4107UKG Glycosyl transferase, family 4 FZN67_18605 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FZN67_18645 ENOG4107QQG Dehydrogenase FZN67_18650 ENOG4105DAY polysaccharide export protein FZN67_18660 ENOG4105D75 Capsular exopolysaccharide family FZN67_18665 ENOG4108V1T peptidylprolyl cis-trans isomerase FZN67_18670 ENOG4108V1T peptidylprolyl cis-trans isomerase FZN67_18675 ENOG4105CJR Integral membrane protein (MviN FZN67_18680 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FZN67_18685 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FZN67_18715 ENOG41062JF Transcriptional regulator FZN67_18730 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FZN67_18735 ENOG4105UBK short-chain dehydrogenase reductase FZN67_18750 ENOG4107QZM n-acetylglutamate synthase FZN67_18755 ENOG4105GVF (ABC) transporter FZN67_18760 ENOG4105GVF (ABC) transporter FZN67_18765 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FZN67_18770 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FZN67_18775 ENOG4108VM9 ABC, transporter FZN67_18780 ENOG4108R86 Transcriptional regulator FZN67_18785 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FZN67_18795 ENOG4105DTN riboflavin biosynthesis protein ribF FZN67_18800 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FZN67_18810 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FZN67_18850 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FZN67_18905 ENOG4105CVE Lytic murein transglycosylase FZN67_18910 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FZN67_18915 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FZN67_18930 ENOG4105DFU Cell wall formation (By similarity) FZN67_18940 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FZN67_18945 ENOG4105DU1 integral membrane protein, terc FZN67_18955 ENOG4106032 Glutathionylspermidine synthase FZN67_18965 ENOG4107QUY Guanine deaminase FZN67_18970 ENOG4108UGV hypoxanthine phosphoribosyltransferase FZN67_18980 ENOG4105T95 Thiol disulfide interChange protein FZN67_18985 ENOG4105PGM cation diffusion facilitator family transporter FZN67_19000 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FZN67_19015 ENOG4105VG0 50S ribosomal protein l34