locus-tag	class	description
OIO74_00010	COG0592	DNA-directed DNA polymerase activity
OIO74_00020	COG0187	DNA topoisomerase II activity
OIO74_00030	COG0586	Pfam SNARE associated Golgi protein
OIO74_00035	COG0488	(ABC) transporter
OIO74_00060	COG0596	Alpha beta hydrolase
OIO74_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OIO74_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OIO74_00110	COG0733	neurotransmitter:sodium symporter activity
OIO74_00145	COG0583	DNA-binding transcription factor activity
OIO74_00150	COG2233	PERMEase
OIO74_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO74_00200	COG2814	Major facilitator Superfamily
OIO74_00205	COG0656	L-ascorbic acid biosynthetic process
OIO74_00210	COG0583	DNA-binding transcription factor activity
OIO74_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO74_00230	COG1064	alcohol dehydrogenase
OIO74_00235	COG2818	Glycosylase
OIO74_00250	COG1194	a g-specific adenine glycosylase
OIO74_00270	COG2983	Belongs to the UPF0260 family
OIO74_00275	COG2133	pyrroloquinoline quinone binding
OIO74_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OIO74_00285	COG2116	formate transmembrane transporter activity
OIO74_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO74_00310	COG1335	isochorismatase
OIO74_00315	COG0385	Bile acid
OIO74_00320	COG0534	Mate efflux family protein
OIO74_00325	COG1683	Conserved Protein
OIO74_00345	COG0625	glutathione transferase activity
OIO74_00355	COG1113	amino acid transport
OIO74_00365	COG0523	cobalamin synthesis protein
OIO74_00375	COG2188	Transcriptional regulator
OIO74_00405	COG0010	Belongs to the arginase family
OIO74_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OIO74_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OIO74_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OIO74_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OIO74_00525	COG0534	Mate efflux family protein
OIO74_00530	COG0436	Aminotransferase
OIO74_00535	COG2733	membrane
OIO74_00550	COG2918	glutathione biosynthetic process
OIO74_00565	COG2826	transposase and inactivated derivatives, IS30 family
OIO74_00575	COG1705	Flagellar rod assembly protein muramidase FlgJ
OIO74_00575	COG3951	Flagellar rod assembly protein muramidase FlgJ
OIO74_00615	COG3150	esterase
OIO74_00625	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
OIO74_00635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO74_00645	COG2233	PERMEase
OIO74_00650	COG2351	hydroxyisourate hydrolase activity
OIO74_00685	COG3706	GGDEF domain
OIO74_00700	COG1393	Belongs to the ArsC family
OIO74_00705	COG0708	Exodeoxyribonuclease III
OIO74_00735	COG0189	ligase activity
OIO74_00755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OIO74_00765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OIO74_00780	COG4942	peptidase
OIO74_00790	COG0508	dehydrogenase complex catalyzes the overall conversion of
OIO74_00800	COG2119	membrane
OIO74_00805	COG4774	siderophore transport
OIO74_00810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO74_00810	COG0426	domain, Protein
OIO74_00835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OIO74_00855	COG1902	pentaerythritol trinitrate reductase activity
OIO74_00860	COG1519	Transferase
OIO74_00865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OIO74_00870	COG0668	transmembrane transport
OIO74_00880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO74_00885	COG1335	isochorismatase
OIO74_00890	COG1522	sequence-specific DNA binding
OIO74_00915	COG0784	Response regulator, receiver
OIO74_00915	COG2198	Histidine kinase
OIO74_00915	COG2205	protein histidine kinase activity
OIO74_00920	COG3162	membrane
OIO74_00925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OIO74_00955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OIO74_00980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OIO74_00980	COG0352	thiamine-phosphate diphosphorylase activity
OIO74_00980	COG0351	phosphomethylpyrimidine kinase
OIO74_00990	COG2826	transposase and inactivated derivatives, IS30 family
OIO74_01000	COG2015	COG2015, Alkyl sulfatase and related hydrolases
OIO74_01010	COG2826	transposase and inactivated derivatives, IS30 family
OIO74_01020	COG2814	Major facilitator Superfamily
OIO74_01035	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OIO74_01045	COG1113	amino acid transport
OIO74_01055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OIO74_01060	COG1012	belongs to the aldehyde dehydrogenase family
OIO74_01070	COG1335	isochorismatase
OIO74_01100	COG2814	Major facilitator Superfamily
OIO74_01105	COG0583	DNA-binding transcription factor activity
OIO74_01125	COG0667	Aldo Keto reductase
OIO74_01160	COG2826	transposase and inactivated derivatives, IS30 family
OIO74_01180	COG1733	regulation of RNA biosynthetic process
OIO74_01185	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO74_01250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OIO74_01290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OIO74_01320	COG0427	acetyl-CoA hydrolase
OIO74_01345	COG0659	secondary active sulfate transmembrane transporter activity
OIO74_01350	COG4221	oxidoreductase activity
OIO74_01355	COG2873	o-acetylhomoserine
OIO74_01360	COG0488	(ABC) transporter
OIO74_01455	COG0833	amino acid
OIO74_01500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OIO74_01505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OIO74_01520	COG2226	methyltransferase
OIO74_01570	COG0067	glutamate synthase
OIO74_01570	COG0069	glutamate synthase activity
OIO74_01570	COG0070	glutamate synthase
OIO74_01575	COG0493	'glutamate synthase
OIO74_01585	COG1704	LemA family
OIO74_01590	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
OIO74_01600	COG4969	Belongs to the N-Me-Phe pilin family
OIO74_01625	COG1061	Type III restriction enzyme res subunit
OIO74_01630	COG1002	Type II restriction enzyme, methylase subunits
OIO74_01655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OIO74_01670	COG0194	GDP metabolic process
OIO74_01720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OIO74_01740	COG5380	lipid catabolic process
OIO74_01745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OIO74_01770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OIO74_01775	COG0277	FAD linked oxidase domain protein
OIO74_01785	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OIO74_01790	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO74_01805	COG1289	transmembrane transporter activity
OIO74_01815	COG0628	permease
OIO74_01820	COG1192	Involved in chromosome partitioning
OIO74_01850	COG0833	amino acid
OIO74_01855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OIO74_01860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OIO74_01870	COG1012	belongs to the aldehyde dehydrogenase family
OIO74_01910	COG0583	DNA-binding transcription factor activity
OIO74_01930	COG0752	glycyl-tRNA synthetase alpha subunit
OIO74_01955	COG0517	IMP dehydrogenase activity
OIO74_01960	COG1983	PspC domain protein
OIO74_01970	COG1960	acyl-CoA dehydrogenase activity
OIO74_01985	COG0408	coproporphyrinogen oxidase activity
OIO74_02005	COG0513	Belongs to the DEAD box helicase family
OIO74_02015	COG1127	ABC transporter
OIO74_02020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OIO74_02030	COG2854	intermembrane phospholipid transfer
OIO74_02040	COG0598	Magnesium transport protein CorA
OIO74_02050	COG0494	nUDIX hydrolase
OIO74_02055	COG1040	competence protein
OIO74_02060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OIO74_02080	COG1946	Acyl-CoA thioesterase
OIO74_02085	COG1301	dicarboxylic acid transport
OIO74_02100	COG1959	2 iron, 2 sulfur cluster binding
OIO74_02105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO74_02105	COG1017	nitric oxide dioxygenase activity
OIO74_02115	COG0433	COG0433 Predicted ATPase
OIO74_02120	COG0626	cystathionine gamma-synthase activity
OIO74_02275	COG1960	acyl-CoA dehydrogenase activity
OIO74_02280	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
OIO74_02310	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
OIO74_02315	COG0339	signal peptide processing
OIO74_02320	COG0557	exoribonuclease II activity
OIO74_02360	COG0179	Fumarylacetoacetate (FAA) hydrolase
OIO74_02365	COG2169	Transcriptional regulator
OIO74_02370	COG0697	spore germination
OIO74_02375	COG1295	ribonuclease BN
OIO74_02410	COG1702	phosphate starvation-inducible protein PhoH
OIO74_02420	COG0741	lytic transglycosylase activity
OIO74_02420	COG0739	heme binding
OIO74_02420	COG1196	nuclear chromosome segregation
OIO74_02450	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OIO74_02455	COG1183	phosphatidylcholine synthase activity
OIO74_02500	COG1960	acyl-CoA dehydrogenase activity
OIO74_02505	COG1309	transcriptional regulator
OIO74_02520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OIO74_02525	COG1960	acyl-CoA dehydrogenase activity
OIO74_02545	COG2969	positive regulation of protein catabolic process
OIO74_02555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OIO74_02565	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
OIO74_02570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OIO74_02575	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OIO74_02595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OIO74_02605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OIO74_02610	COG1408	metallophosphoesterase
OIO74_02620	COG2199	diguanylate cyclase activity
OIO74_02680	COG1607	acyl-coa hydrolase
OIO74_02715	COG3013	Belongs to the UPF0304 family
OIO74_02795	COG2205	protein histidine kinase activity
OIO74_02810	COG2132	Multicopper oxidase
OIO74_02835	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO74_02885	COG0582	viral genome integration into host DNA
OIO74_02910	COG2350	Protein conserved in bacteria
OIO74_02920	COG0613	PHP domain protein
OIO74_02925	COG3781	membrane
OIO74_02935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OIO74_02940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OIO74_02950	COG1862	Preprotein translocase
OIO74_02990	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OIO74_03005	COG0726	polysaccharide deacetylase
OIO74_03010	COG0438	transferase activity, transferring glycosyl groups
OIO74_03030	COG0438	transferase activity, transferring glycosyl groups
OIO74_03035	COG1216	Glycosyl transferase, family 2
OIO74_03040	COG0438	transferase activity, transferring glycosyl groups
OIO74_03085	COG1960	acyl-CoA dehydrogenase activity
OIO74_03090	COG1960	acyl-CoA dehydrogenase activity
OIO74_03100	COG2205	protein histidine kinase activity
OIO74_03105	COG0745	RESPONSE REGULATOR receiver
OIO74_03110	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OIO74_03130	COG2096	Adenosyltransferase
OIO74_03180	COG0285	dihydrofolate synthase activity
OIO74_03200	COG0450	alkyl hydroperoxide reductase
OIO74_03215	COG0477	Major facilitator Superfamily
OIO74_03220	COG1272	protein, Hemolysin III
OIO74_03260	COG0183	Belongs to the thiolase family
OIO74_03265	COG2207	Transcriptional regulator
OIO74_03285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO74_03305	COG0183	Belongs to the thiolase family
OIO74_03315	COG2885	chlorophyll binding
OIO74_03315	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
OIO74_03325	COG1690	Belongs to the RtcB family
OIO74_03330	COG0833	amino acid
OIO74_03340	COG2233	PERMEase
OIO74_03345	COG1217	gtp-binding protein TYPA
OIO74_03370	COG2094	Belongs to the DNA glycosylase MPG family
OIO74_03380	COG1902	pentaerythritol trinitrate reductase activity
OIO74_03395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO74_03400	COG0354	folic acid binding
OIO74_03410	COG3189	MarR family transcriptional regulator
OIO74_03415	COG2824	Alkylphosphonate utilization operon protein PhnA
OIO74_03420	COG3422	double-strand break repair
OIO74_03460	COG0840	transmembrane signaling receptor activity
OIO74_03480	COG5510	response to toxic substance
OIO74_03490	COG2832	Protein of unknown function (DUF454)
OIO74_03495	COG1376	ErfK ybiS ycfS ynhG family protein
OIO74_03535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OIO74_03545	COG1289	transmembrane transporter activity
OIO74_03550	COG2814	Major facilitator Superfamily
OIO74_03570	COG1115	amino acid carrier protein
OIO74_03575	COG1752	Esterase of the alpha-beta hydrolase superfamily
OIO74_03580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OIO74_03585	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
OIO74_03615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OIO74_03625	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OIO74_03630	COG1077	Cell shape determining protein MreB Mrl
OIO74_03635	COG1792	Involved in formation and maintenance of cell shape
OIO74_03640	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OIO74_03645	COG0424	maF-like protein
OIO74_03650	COG1530	ribonuclease E activity
OIO74_03660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO74_03670	COG0560	Phosphoserine phosphatase
OIO74_03680	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO74_03705	COG2207	Transcriptional regulator
OIO74_03725	COG1113	amino acid transport
OIO74_03730	COG2828	Protein conserved in bacteria
OIO74_03735	COG0142	geranyltranstransferase activity
OIO74_03740	COG2315	Protein conserved in bacteria
OIO74_03755	COG1752	Esterase of the alpha-beta hydrolase superfamily
OIO74_03770	COG2826	transposase and inactivated derivatives, IS30 family
OIO74_03780	COG2194	sulfuric ester hydrolase activity
OIO74_03785	COG0745	RESPONSE REGULATOR receiver
OIO74_03790	COG0642	Histidine kinase
OIO74_03800	COG0004	ammonium transporteR
OIO74_03805	COG0583	DNA-binding transcription factor activity
OIO74_03825	COG0525	valine-tRNA ligase activity
OIO74_03835	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_03845	COG0393	Putative heavy-metal-binding
OIO74_03850	COG0393	Putative heavy-metal-binding
OIO74_03855	COG1538	Outer membrane efflux protein
OIO74_03865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO74_03870	COG0671	phosphoesterase, PA-phosphatase related
OIO74_03900	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OIO74_03915	COG1648	precorrin-2 dehydrogenase activity
OIO74_03915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OIO74_03920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OIO74_03925	COG1733	regulation of RNA biosynthetic process
OIO74_03935	COG0531	amino acid
OIO74_03950	COG0321	lipoyl(octanoyl) transferase activity
OIO74_03955	COG2921	Belongs to the UPF0250 family
OIO74_03990	COG2009	succinate dehydrogenase
OIO74_03995	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OIO74_04000	COG1053	succinate dehydrogenase
OIO74_04005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OIO74_04030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO74_04050	COG2354	Protein conserved in bacteria
OIO74_04055	COG2321	neutral zinc metallopeptidase
OIO74_04075	COG2843	Capsule synthesis protein
OIO74_04090	COG0589	response to stress
OIO74_04110	COG0505	Belongs to the CarA family
OIO74_04135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO74_04140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OIO74_04190	COG0477	Major facilitator Superfamily
OIO74_04195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OIO74_04210	COG1597	lipid kinase activity
OIO74_04215	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OIO74_04295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO74_04300	COG0584	glycerophosphoryl diester phosphodiesterase
OIO74_04320	COG0741	lytic transglycosylase activity
OIO74_04340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OIO74_04355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO74_04365	COG3811	Belongs to the UPF0386 family
OIO74_04385	COG2801	Transposase and inactivated derivatives
OIO74_04410	COG0778	Nitroreductase
OIO74_04425	COG1929	Belongs to the glycerate kinase type-1 family
OIO74_04430	COG0243	molybdopterin cofactor binding
OIO74_04435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OIO74_04440	COG3339	Conserved Protein
OIO74_04450	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OIO74_04465	COG1113	amino acid transport
OIO74_04475	COG0019	diaminopimelate decarboxylase activity
OIO74_04485	COG1280	lysine exporter protein (LysE YggA)
OIO74_04490	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OIO74_04520	COG0463	Glycosyl transferase, family 2
OIO74_04540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO74_04575	COG4591	ABC-type transport system involved in lipoprotein release permease component
OIO74_04580	COG1136	(ABC) transporter
OIO74_04585	COG0658	competence protein
OIO74_04585	COG2333	competence protein COMEC
OIO74_04595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OIO74_04595	COG0616	signal peptide processing
OIO74_04600	COG0596	Alpha beta hydrolase
OIO74_04605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OIO74_04615	COG0628	permease
OIO74_04635	COG2826	transposase and inactivated derivatives, IS30 family
OIO74_04660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OIO74_04680	COG0823	Involved in the tonB-independent uptake of proteins
OIO74_04700	COG0824	Thioesterase
OIO74_04705	COG1473	amidohydrolase
OIO74_04725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OIO74_04725	COG0047	phosphoribosylformylglycinamidine synthase activity
OIO74_04730	COG2814	Major facilitator Superfamily
OIO74_04745	COG1024	Enoyl-CoA hydratase
OIO74_04750	COG1056	cytidyltransferase-related domain
OIO74_04750	COG1051	belongs to the nudix hydrolase family
OIO74_04760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OIO74_04775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OIO74_04790	COG4625	pathogenesis
OIO74_04795	COG0583	DNA-binding transcription factor activity
OIO74_04800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OIO74_04805	COG4208	sulfate ABC transporter
OIO74_04810	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OIO74_04820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
OIO74_04825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OIO74_04830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OIO74_04850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OIO74_04860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OIO74_04870	COG0681	Belongs to the peptidase S26 family
OIO74_04885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OIO74_04895	COG1381	Involved in DNA repair and RecF pathway recombination
OIO74_04900	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OIO74_04910	COG4221	oxidoreductase activity
OIO74_04940	COG0436	Aminotransferase
OIO74_04960	COG0556	nucleotide-excision repair
OIO74_05015	COG2070	2-Nitropropane dioxygenase
OIO74_05045	COG1215	transferase activity, transferring glycosyl groups
OIO74_05060	COG0415	Belongs to the DNA photolyase family
OIO74_05070	COG1252	NADH dehydrogenase
OIO74_05075	COG1686	Belongs to the peptidase S11 family
OIO74_05090	COG1187	pseudouridine synthase activity
OIO74_05115	COG0477	Major facilitator Superfamily
OIO74_05120	COG0583	DNA-binding transcription factor activity
OIO74_05125	COG1823	symporter activity
OIO74_05135	COG0612	Peptidase, M16
OIO74_05160	COG0352	thiamine-phosphate diphosphorylase activity
OIO74_05195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO74_05220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OIO74_05225	COG0076	glutamate decarboxylase activity
OIO74_05235	COG1522	sequence-specific DNA binding
OIO74_05240	COG3961	Belongs to the TPP enzyme family
OIO74_05245	COG1113	amino acid transport
OIO74_05250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OIO74_05255	COG0573	inorganic phosphate transmembrane transporter activity
OIO74_05265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OIO74_05270	COG0616	signal peptide processing
OIO74_05305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OIO74_05310	COG1686	Belongs to the peptidase S11 family
OIO74_05335	COG0583	DNA-binding transcription factor activity
OIO74_05340	COG1067	ATP-dependent peptidase activity
OIO74_05365	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OIO74_05385	COG1966	Carbon starvation protein
OIO74_05390	COG2879	small protein
OIO74_05410	COG2801	Transposase and inactivated derivatives
OIO74_05430	COG1741	Belongs to the pirin family
OIO74_05440	COG2964	Protein conserved in bacteria
OIO74_05455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO74_05465	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OIO74_05470	COG4605	iron ion homeostasis
OIO74_05475	COG4604	ABC transporter, ATP-binding protein
OIO74_05480	COG4607	ABC-type enterochelin transport system periplasmic component
OIO74_05485	COG4774	siderophore transport
OIO74_05495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO74_05500	COG1021	2,3-dihydroxybenzoate-AMP ligase
OIO74_05505	COG1535	isochorismatase
OIO74_05505	COG3433	isochorismatase activity
OIO74_05515	COG1132	(ABC) transporter
OIO74_05520	COG1132	(ABC) transporter
OIO74_05525	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
OIO74_05530	COG2977	Belongs to the P-Pant transferase superfamily
OIO74_05535	COG1169	isochorismate synthase
OIO74_05550	COG3739	integral membrane protein
OIO74_05570	COG0302	gtp cyclohydrolase
OIO74_05580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OIO74_05610	COG0308	aminopeptidase N
OIO74_05615	COG0512	Glutamine amidotransferase of anthranilate synthase
OIO74_05630	COG0174	glutamine synthetase
OIO74_05640	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OIO74_05675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OIO74_05680	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OIO74_05685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OIO74_05705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OIO74_05710	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OIO74_05715	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OIO74_05730	COG1960	acyl-CoA dehydrogenase activity
OIO74_05735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OIO74_05740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO74_05750	COG2223	nitrite transmembrane transporter activity
OIO74_05760	COG0024	Methionine aminopeptidase
OIO74_05765	COG0052	Belongs to the universal ribosomal protein uS2 family
OIO74_05780	COG2207	Transcriptional regulator
OIO74_05805	COG2951	lytic endotransglycosylase activity
OIO74_05810	COG0772	Belongs to the SEDS family
OIO74_05825	COG0842	Transport permease protein
OIO74_05830	COG1131	(ABC) transporter
OIO74_05875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO74_05890	COG4215	(ABC) transporter
OIO74_05895	COG4160	amino acid transport
OIO74_05900	COG4598	ABC transporter
OIO74_05910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO74_05915	COG0826	peptidase U32
OIO74_05920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO74_05935	COG1720	tRNA m6t6A37 methyltransferase activity
OIO74_05945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OIO74_05960	COG0642	Histidine kinase
OIO74_05970	COG0494	nUDIX hydrolase
OIO74_05980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OIO74_05985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OIO74_05990	COG3139	Protein of unknown function (DUF1315)
OIO74_06000	COG1301	dicarboxylic acid transport
OIO74_06005	COG1960	acyl-CoA dehydrogenase activity
OIO74_06010	COG2819	hydrolase of the alpha beta superfamily
OIO74_06020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OIO74_06030	COG2195	Cleaves the N-terminal amino acid of tripeptides
OIO74_06035	COG1234	tRNA 3'-trailer cleavage
OIO74_06065	COG2363	Small membrane protein
OIO74_06090	COG0513	Belongs to the DEAD box helicase family
OIO74_06100	COG0778	Nitroreductase
OIO74_06130	COG1286	toxin biosynthetic process
OIO74_06155	COG4783	chaperone-mediated protein folding
OIO74_06160	COG1610	YqeY-like protein
OIO74_06215	COG2831	hemolysin activation secretion protein
OIO74_06220	COG3210	domain, Protein
OIO74_06220	COG3210	domain, Protein
OIO74_06220	COG3210	domain, Protein
OIO74_06290	COG3111	PFAM Bacterial OB fold (BOF) protein
OIO74_06315	COG3243	poly(R)-hydroxyalkanoic acid synthase
OIO74_06320	COG0786	glutamate:sodium symporter activity
OIO74_06330	COG2186	Transcriptional regulator
OIO74_06380	COG0477	Major facilitator Superfamily
OIO74_06410	COG2995	paraquat-inducible protein a
OIO74_06415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OIO74_06415	COG3008	intermembrane lipid transfer
OIO74_06425	COG2351	hydroxyisourate hydrolase activity
OIO74_06465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OIO74_06475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OIO74_06480	COG0642	Histidine kinase
OIO74_06485	COG0745	RESPONSE REGULATOR receiver
OIO74_06505	COG1794	racemase activity, acting on amino acids and derivatives
OIO74_06535	COG1301	dicarboxylic acid transport
OIO74_06545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO74_06550	COG2011	ABC-type metal ion transport system permease component
OIO74_06555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO74_06560	COG1464	Belongs to the NlpA lipoprotein family
OIO74_06565	COG0151	Belongs to the GarS family
OIO74_06570	COG0138	bifunctional purine biosynthesis protein purh
OIO74_06575	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OIO74_06605	COG2308	Evidence 4 Homologs of previously reported genes of
OIO74_06615	COG1305	Transglutaminase-like
OIO74_06625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OIO74_06630	COG0305	Participates in initiation and elongation during chromosome replication
OIO74_06655	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OIO74_06665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OIO74_06670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OIO74_06695	COG0726	polysaccharide deacetylase
OIO74_06695	COG1649	PFAM Uncharacterised BCR, COG1649
OIO74_06700	COG1215	transferase activity, transferring glycosyl groups
OIO74_06705	COG3658	cytochrome
OIO74_06715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO74_06730	COG0583	DNA-binding transcription factor activity
OIO74_06750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO74_06755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO74_06770	COG1960	acyl-CoA dehydrogenase activity
OIO74_06775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO74_06780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO74_06805	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OIO74_06810	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OIO74_06820	COG2205	protein histidine kinase activity
OIO74_06825	COG0745	RESPONSE REGULATOR receiver
OIO74_06830	COG0174	glutamine synthetase
OIO74_06850	COG0729	surface antigen
OIO74_06875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OIO74_06880	COG2814	Major facilitator Superfamily
OIO74_06895	COG0583	DNA-binding transcription factor activity
OIO74_06910	COG1187	pseudouridine synthase activity
OIO74_06930	COG0802	atpase or kinase
OIO74_06935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OIO74_06945	COG1923	regulation of RNA biosynthetic process
OIO74_06950	COG0697	spore germination
OIO74_06965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO74_06975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OIO74_06980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OIO74_06980	COG0519	Catalyzes the synthesis of GMP from XMP
OIO74_06985	COG4302	ethanolamine ammonia-lyase activity
OIO74_06990	COG4303	Ethanolamine ammonia lyase large subunit
OIO74_06995	COG0531	amino acid
OIO74_07015	COG1454	alcohol dehydrogenase
OIO74_07020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OIO74_07030	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
OIO74_07050	COG0308	aminopeptidase N
OIO74_07090	COG1605	Chorismate mutase
OIO74_07105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OIO74_07120	COG2801	Transposase and inactivated derivatives
OIO74_07130	COG1309	transcriptional regulator
OIO74_07140	COG0668	transmembrane transport
OIO74_07170	COG4773	Receptor
OIO74_07190	COG0488	(ABC) transporter
OIO74_07195	COG0589	response to stress
OIO74_07220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OIO74_07230	COG3135	benzoate transporter
OIO74_07235	COG1522	sequence-specific DNA binding
OIO74_07245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OIO74_07250	COG0583	DNA-binding transcription factor activity
OIO74_07260	COG0183	Belongs to the thiolase family
OIO74_07270	COG2030	dehydratase
OIO74_07300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OIO74_07315	COG0824	Thioesterase
OIO74_07320	COG1454	alcohol dehydrogenase
OIO74_07330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OIO74_07350	COG0069	glutamate synthase activity
OIO74_07480	COG1484	DNA-dependent DNA replication
OIO74_07670	COG2026	Addiction module toxin, RelE StbE family
OIO74_07715	COG0592	DNA-directed DNA polymerase activity
OIO74_07785	COG2814	Major facilitator Superfamily
OIO74_07800	COG0511	ligase activity, forming carbon-carbon bonds
OIO74_07820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO74_07820	COG1116	anion transmembrane transporter activity
OIO74_07825	COG0745	RESPONSE REGULATOR receiver
OIO74_07835	COG2146	nitrite reductase [NAD(P)H] activity
OIO74_07835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO74_07840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO74_07845	COG0243	molybdopterin cofactor binding
OIO74_07855	COG0243	molybdopterin cofactor binding
OIO74_07860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OIO74_07875	COG0315	cyclic pyranopterin monophosphate synthase activity
OIO74_07875	COG0521	Mo-molybdopterin cofactor biosynthetic process
OIO74_07880	COG0303	'Molybdopterin
OIO74_07890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO74_07895	COG0697	spore germination
OIO74_07915	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OIO74_07920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OIO74_07975	COG2204	response regulator
OIO74_07980	COG3852	Histidine kinase
OIO74_08005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OIO74_08010	COG0575	Belongs to the CDS family
OIO74_08025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OIO74_08045	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO74_08060	COG2137	regulation of response to DNA damage stimulus
OIO74_08070	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OIO74_08075	COG1011	Hydrolase
OIO74_08090	COG2826	transposase and inactivated derivatives, IS30 family
OIO74_08105	COG1522	sequence-specific DNA binding
OIO74_08115	COG1113	amino acid transport
OIO74_08135	COG0659	secondary active sulfate transmembrane transporter activity
OIO74_08140	COG2135	peptidase activity
OIO74_08155	COG3300	MHYT domain
OIO74_08155	COG5001	Diguanylate cyclase
OIO74_08170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OIO74_08170	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
OIO74_08170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OIO74_08175	COG1105	Belongs to the carbohydrate kinase PfkB family
OIO74_08180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OIO74_08180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OIO74_08210	COG0024	Methionine aminopeptidase
OIO74_08215	COG0583	DNA-binding transcription factor activity
OIO74_08225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OIO74_08230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OIO74_08235	COG0516	GMP reductase activity
OIO74_08235	COG0517	IMP dehydrogenase activity
OIO74_08260	COG0552	protein localization to endoplasmic reticulum
OIO74_08270	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
OIO74_08285	COG4890	Cyd operon protein YbgT
OIO74_08290	COG1294	oxidase, subunit
OIO74_08305	COG1585	Membrane protein implicated in regulation of membrane protease activity
OIO74_08315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OIO74_08320	COG4774	siderophore transport
OIO74_08335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OIO74_08340	COG0569	domain protein
OIO74_08345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OIO74_08375	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OIO74_08380	COG0542	response to heat
OIO74_08390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OIO74_08405	COG1902	pentaerythritol trinitrate reductase activity
OIO74_08405	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO74_08450	COG2323	membrane
OIO74_08455	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OIO74_08465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO74_08470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO74_08475	COG0183	Belongs to the thiolase family
OIO74_08480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OIO74_08485	COG0596	Alpha beta hydrolase
OIO74_08490	COG2271	Major facilitator Superfamily
OIO74_08495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OIO74_08500	COG3485	protocatechuate 3,4-dioxygenase
OIO74_08505	COG3485	protocatechuate 3,4-dioxygenase
OIO74_08510	COG0710	3-dehydroquinate dehydratase activity
OIO74_08515	COG3420	alginic acid biosynthetic process
OIO74_08520	COG3659	wide pore channel activity
OIO74_08525	COG4993	Dehydrogenase
OIO74_08535	COG2391	methyltransferase activity
OIO74_08550	COG1414	Transcriptional regulator
OIO74_08555	COG0583	DNA-binding transcription factor activity
OIO74_08560	COG1960	acyl-CoA dehydrogenase activity
OIO74_08585	COG2814	Major facilitator Superfamily
OIO74_08595	COG0154	amidase activity
OIO74_08615	COG4638	Rieske (2fe-2S)
OIO74_08625	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_08635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO74_08645	COG3733	amine oxidase
OIO74_08655	COG1012	belongs to the aldehyde dehydrogenase family
OIO74_08665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO74_08670	COG0183	Belongs to the thiolase family
OIO74_08675	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO74_08680	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO74_08690	COG4829	muconolactone delta-isomerase
OIO74_08695	COG4948	Mandelate Racemase Muconate Lactonizing
OIO74_08700	COG0583	DNA-binding transcription factor activity
OIO74_08710	COG2186	Transcriptional regulator
OIO74_08730	COG1012	belongs to the aldehyde dehydrogenase family
OIO74_08745	COG1902	pentaerythritol trinitrate reductase activity
OIO74_08745	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO74_08785	COG1309	transcriptional regulator
OIO74_08795	COG1335	isochorismatase
OIO74_08800	COG0583	DNA-binding transcription factor activity
OIO74_08810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO74_08810	COG0475	glutathione-regulated potassium exporter activity
OIO74_08820	COG1473	amidohydrolase
OIO74_08835	COG4191	Histidine kinase
OIO74_08870	COG2188	Transcriptional regulator
OIO74_08885	COG0583	DNA-binding transcription factor activity
OIO74_08900	COG1566	PFAM secretion protein HlyD family protein
OIO74_08915	COG1012	belongs to the aldehyde dehydrogenase family
OIO74_08920	COG0129	dihydroxy-acid dehydratase activity
OIO74_08930	COG0583	DNA-binding transcription factor activity
OIO74_08935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OIO74_08945	COG2084	Dehydrogenase
OIO74_08950	COG2207	Transcriptional regulator
OIO74_08965	COG1064	alcohol dehydrogenase
OIO74_08975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OIO74_08980	COG1120	ATPase activity
OIO74_09000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OIO74_09050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OIO74_09090	COG2826	transposase and inactivated derivatives, IS30 family
OIO74_09120	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_09135	COG2207	Transcriptional regulator
OIO74_09145	COG2205	protein histidine kinase activity
OIO74_09165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO74_09170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO74_09185	COG3539	Fimbrial protein
OIO74_09210	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OIO74_09220	COG0753	catalase activity
OIO74_09240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OIO74_09305	COG1535	isochorismatase
OIO74_09305	COG3433	isochorismatase activity
OIO74_09310	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_09315	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OIO74_09320	COG4149	molybdate abc transporter
OIO74_09325	COG0725	ABC transporter, periplasmic molybdate-binding protein
OIO74_09335	COG4638	Rieske (2fe-2S)
OIO74_09340	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
OIO74_09345	COG0543	2 iron, 2 sulfur cluster binding
OIO74_09345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO74_09360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO74_09370	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_09385	COG2207	Transcriptional regulator
OIO74_09390	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_09395	COG2610	gluconate transmembrane transporter activity
OIO74_09405	COG1309	transcriptional regulator
OIO74_09425	COG0583	DNA-binding transcription factor activity
OIO74_09440	COG2031	fatty acid transporter
OIO74_09445	COG0183	Belongs to the thiolase family
OIO74_09450	COG0583	DNA-binding transcription factor activity
OIO74_09455	COG0583	DNA-binding transcription factor activity
OIO74_09470	COG1027	Aspartate ammonia-lyase
OIO74_09480	COG0477	Major facilitator Superfamily
OIO74_09500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO74_09505	COG4521	taurine ABC transporter
OIO74_09520	COG2188	Transcriptional regulator
OIO74_09530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OIO74_09535	COG1733	regulation of RNA biosynthetic process
OIO74_09540	COG2207	Transcriptional regulator
OIO74_09540	COG3708	Transcriptional regulator
OIO74_09555	COG0730	response to heat
OIO74_09580	COG3781	membrane
OIO74_09585	COG1063	alcohol dehydrogenase
OIO74_09595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO74_09600	COG0508	dehydrogenase complex catalyzes the overall conversion of
OIO74_09605	COG0022	dehydrogenase e1 component
OIO74_09610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OIO74_09615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OIO74_09630	COG3706	GGDEF domain
OIO74_09645	COG0133	tryptophan synthase activity
OIO74_09655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO74_09690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OIO74_09715	COG2226	methyltransferase
OIO74_09770	COG0842	Transport permease protein
OIO74_09775	COG0842	Transport permease protein
OIO74_09780	COG1131	(ABC) transporter
OIO74_09795	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO74_09800	COG4773	Receptor
OIO74_09820	COG0730	response to heat
OIO74_09825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OIO74_09840	COG0406	alpha-ribazole phosphatase activity
OIO74_09845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OIO74_09860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OIO74_09890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OIO74_09900	COG4264	IucA IucC family
OIO74_09905	COG4264	IucA IucC family
OIO74_09925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OIO74_09940	COG1960	acyl-CoA dehydrogenase activity
OIO74_09945	COG1960	acyl-CoA dehydrogenase activity
OIO74_09950	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO74_09955	COG2207	Transcriptional regulator
OIO74_09960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OIO74_09965	COG0776	regulation of translation
OIO74_09990	COG0822	iron-sulfur transferase activity
OIO74_09995	COG0316	Belongs to the HesB IscA family
OIO74_10025	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OIO74_10045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OIO74_10050	COG0702	epimerase
OIO74_10085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OIO74_10095	COG0339	signal peptide processing
OIO74_10155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OIO74_10160	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OIO74_10190	COG0776	regulation of translation
OIO74_10255	COG0084	hydrolase, TatD family'
OIO74_10275	COG1663	tetraacyldisaccharide 4'-kinase activity
OIO74_10280	COG1132	(ABC) transporter
OIO74_10290	COG0811	peptide transport
OIO74_10295	COG1475	DNA binding
OIO74_10300	COG1192	Involved in chromosome partitioning
OIO74_10310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OIO74_10325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OIO74_10330	COG0191	fructose-bisphosphate aldolase activity
OIO74_10350	COG0424	maF-like protein
OIO74_10355	COG2850	peptidyl-arginine hydroxylation
OIO74_10365	COG0640	Transcriptional regulator
OIO74_10375	COG3619	membrane
OIO74_10380	COG3122	Protein conserved in bacteria
OIO74_10385	COG1132	(ABC) transporter
OIO74_10405	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OIO74_10410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OIO74_10420	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OIO74_10420	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OIO74_10420	COG0506	proline dehydrogenase activity
OIO74_10425	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
OIO74_10440	COG3698	Phosphodiester glycosidase
OIO74_10450	COG2353	YceI-like domain
OIO74_10460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OIO74_10505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OIO74_10505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OIO74_10530	COG3539	Fimbrial protein
OIO74_10535	COG3121	Chaperone
OIO74_10560	COG0697	spore germination
OIO74_10570	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OIO74_10580	COG0583	DNA-binding transcription factor activity
OIO74_10640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OIO74_10640	COG0784	Response regulator, receiver
OIO74_10645	COG0582	viral genome integration into host DNA
OIO74_10655	COG1309	transcriptional regulator
OIO74_10670	COG1522	sequence-specific DNA binding
OIO74_10680	COG1126	abc transporter atp-binding protein
OIO74_10685	COG0765	amino acid transport
OIO74_10690	COG0765	amino acid transport
OIO74_10720	COG1464	Belongs to the NlpA lipoprotein family
OIO74_10730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO74_10735	COG2011	ABC-type metal ion transport system permease component
OIO74_10740	COG0012	GTP binding
OIO74_10765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OIO74_10805	COG0386	Belongs to the glutathione peroxidase family
OIO74_10815	COG0436	Aminotransferase
OIO74_10820	COG1301	dicarboxylic acid transport
OIO74_10855	COG3634	alkyl hydroperoxide reductase activity
OIO74_10870	COG0583	DNA-binding transcription factor activity
OIO74_10875	COG0798	PFAM Bile acid sodium symporter
OIO74_10880	COG0640	Transcriptional regulator
OIO74_10895	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
OIO74_10905	COG0583	DNA-binding transcription factor activity
OIO74_10915	COG1953	Uracil, thiamine, allantoin
OIO74_10925	COG2175	clavaminate synthase activity
OIO74_10930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO74_10935	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
OIO74_10940	COG4521	taurine ABC transporter
OIO74_10950	COG0477	Major facilitator Superfamily
OIO74_10970	COG1271	oxidase subunit
OIO74_10975	COG1294	oxidase, subunit
OIO74_10985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO74_11005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OIO74_11025	COG3052	prosthetic group binding
OIO74_11030	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
OIO74_11040	COG0583	DNA-binding transcription factor activity
OIO74_11050	COG2814	Major facilitator Superfamily
OIO74_11070	COG1346	cytolysis
OIO74_11080	COG0583	DNA-binding transcription factor activity
OIO74_11085	COG0625	glutathione transferase activity
OIO74_11090	COG0625	glutathione transferase activity
OIO74_11095	COG0583	DNA-binding transcription factor activity
OIO74_11110	COG1045	serine acetyltransferase
OIO74_11115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OIO74_11120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OIO74_11125	COG1280	lysine exporter protein (LysE YggA)
OIO74_11140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO74_11145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO74_11150	COG1126	abc transporter atp-binding protein
OIO74_11155	COG0765	amino acid transport
OIO74_11160	COG0765	amino acid transport
OIO74_11180	COG2205	protein histidine kinase activity
OIO74_11180	COG0784	Response regulator, receiver
OIO74_11200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OIO74_11220	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_11240	COG2826	transposase and inactivated derivatives, IS30 family
OIO74_11275	COG0583	DNA-binding transcription factor activity
OIO74_11295	COG0318	PFAM AMP-dependent synthetase and ligase
OIO74_11300	COG1309	transcriptional regulator
OIO74_11305	COG1960	acyl-CoA dehydrogenase activity
OIO74_11310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OIO74_11315	COG1024	Enoyl-CoA hydratase
OIO74_11320	COG4770	biotin carboxylase activity
OIO74_11330	COG0583	DNA-binding transcription factor activity
OIO74_11345	COG1960	acyl-CoA dehydrogenase activity
OIO74_11355	COG2814	Major facilitator Superfamily
OIO74_11365	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO74_11370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO74_11375	COG2814	Major facilitator Superfamily
OIO74_11380	COG1960	acyl-CoA dehydrogenase activity
OIO74_11385	COG1024	Enoyl-CoA hydratase
OIO74_11390	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_11395	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO74_11400	COG0183	Belongs to the thiolase family
OIO74_11410	COG2814	Major facilitator Superfamily
OIO74_11420	COG1024	Enoyl-CoA hydratase
OIO74_11435	COG1960	acyl-CoA dehydrogenase activity
OIO74_11440	COG2814	Major facilitator Superfamily
OIO74_11445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OIO74_11450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OIO74_11465	COG3842	ATPase activity
OIO74_11470	COG1840	ABC-type Fe3 transport system, periplasmic component
OIO74_11480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO74_11485	COG1414	Transcriptional regulator
OIO74_11495	COG0583	DNA-binding transcription factor activity
OIO74_11500	COG3038	cytochrome b561
OIO74_11505	COG0753	catalase activity
OIO74_11510	COG2271	Major facilitator Superfamily
OIO74_11515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OIO74_11520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OIO74_11535	COG2207	Transcriptional regulator
OIO74_11575	COG2050	protein possibly involved in aromatic compounds catabolism
OIO74_11585	COG3327	negative regulation of DNA-templated transcription, initiation
OIO74_11590	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
OIO74_11595	COG0183	Belongs to the thiolase family
OIO74_11600	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO74_11605	COG1024	Enoyl-CoA hydratase
OIO74_11610	COG1024	Enoyl-CoA hydratase
OIO74_11615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO74_11620	COG2151	metal-sulfur cluster biosynthetic enzyme
OIO74_11625	COG3396	Phenylacetate-CoA oxygenase
OIO74_11630	COG3460	Phenylacetate-CoA oxygenase
OIO74_11635	COG3396	Phenylacetate-CoA oxygenase
OIO74_11640	COG1012	belongs to the aldehyde dehydrogenase family
OIO74_11640	COG2030	dehydratase
OIO74_11645	COG1760	l-serine dehydratase
OIO74_11650	COG0531	amino acid
OIO74_11655	COG1012	belongs to the aldehyde dehydrogenase family
OIO74_11700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO74_11730	COG1309	transcriptional regulator
OIO74_11755	COG0038	chloride channel
OIO74_11760	COG4770	biotin carboxylase activity
OIO74_11780	COG1914	H( )-stimulated, divalent metal cation uptake system
OIO74_11815	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO74_11850	COG2801	Transposase and inactivated derivatives
OIO74_11855	COG1560	Kdo2-lipid A biosynthetic process
OIO74_11865	COG5006	permease, DMT superfamily
OIO74_11870	COG1522	sequence-specific DNA binding
OIO74_11885	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OIO74_11895	COG4122	O-methyltransferase activity
OIO74_11930	COG1137	ATPase activity
OIO74_11935	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OIO74_11945	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OIO74_11950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OIO74_11950	COG0517	IMP dehydrogenase activity
OIO74_11985	COG2814	Major facilitator Superfamily
OIO74_12020	COG1278	Cold shock
OIO74_12025	COG1280	lysine exporter protein (LysE YggA)
OIO74_12055	COG1570	exodeoxyribonuclease VII activity
OIO74_12105	COG0583	DNA-binding transcription factor activity
OIO74_12115	COG4638	Rieske (2fe-2S)
OIO74_12120	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
OIO74_12125	COG0633	Ferredoxin
OIO74_12125	COG0543	2 iron, 2 sulfur cluster binding
OIO74_12130	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_12135	COG3135	benzoate transporter
OIO74_12140	COG2814	Major facilitator Superfamily
OIO74_12155	COG1643	Atp-dependent helicase
OIO74_12160	COG0450	alkyl hydroperoxide reductase
OIO74_12170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OIO74_12180	COG3634	alkyl hydroperoxide reductase activity
OIO74_12200	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OIO74_12205	COG0625	glutathione transferase activity
OIO74_12215	COG2885	chlorophyll binding
OIO74_12250	COG0542	response to heat
OIO74_12265	COG1765	OsmC-like protein
OIO74_12280	COG0667	Aldo Keto reductase
OIO74_12295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OIO74_12305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OIO74_12425	COG1598	PFAM Uncharacterised protein family UPF0150
OIO74_12660	COG0527	aspartate kinase activity
OIO74_12670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OIO74_12680	COG3038	cytochrome b561
OIO74_12685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OIO74_12690	COG2252	PERMEase
OIO74_12700	COG2072	flavoprotein involved in K transport
OIO74_12715	COG1741	Belongs to the pirin family
OIO74_12720	COG1309	transcriptional regulator
OIO74_12730	COG0300	oxidoreductase activity
OIO74_12735	COG2072	flavoprotein involved in K transport
OIO74_12740	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
OIO74_12785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO74_12800	COG2814	Major facilitator Superfamily
OIO74_12805	COG1024	Enoyl-CoA hydratase
OIO74_12810	COG1012	belongs to the aldehyde dehydrogenase family
OIO74_12820	COG1960	acyl-CoA dehydrogenase activity
OIO74_12845	COG2186	Transcriptional regulator
OIO74_12850	COG1012	belongs to the aldehyde dehydrogenase family
OIO74_12860	COG4948	Mandelate Racemase Muconate Lactonizing
OIO74_12865	COG2271	Major facilitator Superfamily
OIO74_12870	COG2721	sulfolactate sulfo-lyase activity
OIO74_12875	COG0697	spore germination
OIO74_12890	COG1113	amino acid transport
OIO74_12910	COG1012	belongs to the aldehyde dehydrogenase family
OIO74_12930	COG0531	amino acid
OIO74_12940	COG1113	amino acid transport
OIO74_12975	COG3209	COG3209 Rhs family protein
OIO74_12995	COG2801	Transposase and inactivated derivatives
OIO74_13035	COG1902	pentaerythritol trinitrate reductase activity
OIO74_13035	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO74_13045	COG2203	Gaf domain
OIO74_13045	COG4251	negative regulation of phosphorylation
OIO74_13045	COG3706	GGDEF domain
OIO74_13045	COG5001	Diguanylate cyclase
OIO74_13055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO74_13075	COG4172	Belongs to the ABC transporter superfamily
OIO74_13080	COG4239	(ABC) transporter, permease
OIO74_13085	COG4174	ABC transporter (Permease)
OIO74_13095	COG0741	lytic transglycosylase activity
OIO74_13095	COG1388	LysM domain
OIO74_13095	COG1388	LysM domain
OIO74_13095	COG0741	lytic transglycosylase activity
OIO74_13100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO74_13140	COG0583	DNA-binding transcription factor activity
OIO74_13145	COG1279	arginine transmembrane transporter activity
OIO74_13165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO74_13170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO74_13175	COG0006	proline dipeptidase activity
OIO74_13215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OIO74_13250	COG3384	dioxygenase
OIO74_13260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OIO74_13265	COG2878	Part of a membrane complex involved in electron transport
OIO74_13270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OIO74_13295	COG0768	penicillin binding
OIO74_13300	COG0742	ribosomal rna small subunit methyltransferase
OIO74_13315	COG0830	nickel cation binding
OIO74_13325	COG0804	urea catabolic process
OIO74_13365	COG1253	flavin adenine dinucleotide binding
OIO74_13370	COG2851	Citrate transporter
OIO74_13420	COG1773	rubredoxin
OIO74_13425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO74_13435	COG0583	DNA-binding transcription factor activity
OIO74_13465	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
OIO74_13470	COG4181	ATPase activity
OIO74_13515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OIO74_13535	COG0306	phosphate transporter
OIO74_13545	COG3958	Transketolase
OIO74_13550	COG3959	Transketolase, thiamine diphosphate binding domain
OIO74_13555	COG2271	Major facilitator Superfamily
OIO74_13560	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_13565	COG0583	DNA-binding transcription factor activity
OIO74_13580	COG2223	nitrite transmembrane transporter activity
OIO74_13585	COG2207	Transcriptional regulator
OIO74_13590	COG2066	Belongs to the glutaminase family
OIO74_13595	COG0242	peptide deformylase activity
OIO74_13600	COG0477	Major facilitator Superfamily
OIO74_13610	COG0028	Belongs to the TPP enzyme family
OIO74_13625	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_13630	COG2267	carboxylic ester hydrolase activity
OIO74_13640	COG2271	Major facilitator Superfamily
OIO74_13655	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_13675	COG1414	Transcriptional regulator
OIO74_13690	COG1024	Enoyl-CoA hydratase
OIO74_13700	COG1215	transferase activity, transferring glycosyl groups
OIO74_13705	COG0726	polysaccharide deacetylase
OIO74_13705	COG1649	PFAM Uncharacterised BCR, COG1649
OIO74_13715	COG4681	YaeQ
OIO74_13725	COG0523	cobalamin synthesis protein
OIO74_13735	COG1607	acyl-coa hydrolase
OIO74_13745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO74_13750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO74_13755	COG1309	transcriptional regulator
OIO74_13780	COG2040	homocysteine
OIO74_13785	COG0531	amino acid
OIO74_13810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO74_13815	COG0477	Major facilitator Superfamily
OIO74_13865	COG2826	transposase and inactivated derivatives, IS30 family
OIO74_13880	COG0405	Gamma-glutamyltransferase
OIO74_13885	COG2814	Major facilitator Superfamily
OIO74_13895	COG2050	protein possibly involved in aromatic compounds catabolism
OIO74_13910	COG1090	epimerase
OIO74_13930	COG0420	3'-5' exonuclease activity
OIO74_13955	COG0735	belongs to the Fur family
OIO74_13960	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OIO74_13980	COG0121	glutamine amidotransferase
OIO74_13995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO74_14005	COG0210	DNA helicase
OIO74_14010	COG2885	chlorophyll binding
OIO74_14015	COG0204	Acyl-transferase
OIO74_14030	COG2894	cell division
OIO74_14050	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OIO74_14050	COG1674	ftsk spoiiie
OIO74_14055	COG0492	ferredoxin-NADP+ reductase activity
OIO74_14060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OIO74_14070	COG0456	acetyltransferase
OIO74_14115	COG1981	membrane
OIO74_14130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OIO74_14130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OIO74_14150	COG1012	belongs to the aldehyde dehydrogenase family
OIO74_14160	COG0657	acetylesterase activity
OIO74_14170	COG0473	3-isopropylmalate dehydrogenase activity
OIO74_14175	COG0583	DNA-binding transcription factor activity
OIO74_14195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO74_14220	COG0564	pseudouridine synthase activity
OIO74_14230	COG0358	DNA primase activity
OIO74_14245	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OIO74_14265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OIO74_14295	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OIO74_14305	COG0351	phosphomethylpyrimidine kinase
OIO74_14305	COG0352	thiamine-phosphate diphosphorylase activity
OIO74_14305	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OIO74_14310	COG1652	LysM domain
OIO74_14335	COG1399	metal-binding, possibly nucleic acid-binding protein
OIO74_14340	COG3101	peptidyl-lysine hydroxylation
OIO74_14345	COG0009	L-threonylcarbamoyladenylate synthase
OIO74_14350	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OIO74_14355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OIO74_14370	COG4106	trans-aconitate 2-methyltransferase activity
OIO74_14385	COG0596	Alpha beta hydrolase
OIO74_14385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO74_14385	COG2226	methyltransferase
OIO74_14390	COG1877	trehalose-phosphatase activity
OIO74_14395	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
OIO74_14400	COG2223	nitrite transmembrane transporter activity
OIO74_14420	COG1196	nuclear chromosome segregation
OIO74_14430	COG0730	response to heat
OIO74_14445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OIO74_14505	COG0489	protein tyrosine kinase activity
OIO74_14515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO74_14515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO74_14545	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OIO74_14550	COG2081	HI0933 family
OIO74_14560	COG0668	transmembrane transport
OIO74_14580	COG0583	DNA-binding transcription factor activity
OIO74_14605	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OIO74_14610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OIO74_14640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OIO74_14680	COG0745	RESPONSE REGULATOR receiver
OIO74_14700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OIO74_14720	COG5290	Psort location Cytoplasmic, score
OIO74_14730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO74_14745	COG0583	DNA-binding transcription factor activity
OIO74_14755	COG0583	DNA-binding transcription factor activity
OIO74_14770	COG0583	DNA-binding transcription factor activity
OIO74_14775	COG1053	succinate dehydrogenase
OIO74_14790	COG1309	transcriptional regulator
OIO74_14795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OIO74_14800	COG2814	Major facilitator Superfamily
OIO74_14805	COG1960	acyl-CoA dehydrogenase activity
OIO74_14810	COG0583	DNA-binding transcription factor activity
OIO74_14815	COG1063	alcohol dehydrogenase
OIO74_14845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OIO74_14850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OIO74_14855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OIO74_14875	COG2132	Multicopper oxidase
OIO74_14885	COG0561	phosphatase activity
OIO74_14890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OIO74_14915	COG1214	PFAM Peptidase M22, glycoprotease
OIO74_14950	COG2826	transposase and inactivated derivatives, IS30 family
OIO74_14985	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OIO74_14990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OIO74_14995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OIO74_15055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OIO74_15065	COG1846	Transcriptional regulator
OIO74_15070	COG1764	response to oxidative stress
OIO74_15110	COG0037	tRNA processing
OIO74_15120	COG0248	Ppx GppA phosphatase
OIO74_15150	COG0072	phenylalanine-tRNA ligase activity
OIO74_15195	COG1238	metal cluster binding
OIO74_15200	COG0625	glutathione transferase activity
OIO74_15215	COG0318	PFAM AMP-dependent synthetase and ligase
OIO74_15220	COG3028	Belongs to the UPF0307 family
OIO74_15225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OIO74_15245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OIO74_15250	COG0617	tRNA 3'-terminal CCA addition
OIO74_15255	COG1555	photosystem II stabilization
OIO74_15260	COG3956	TIGRFAM MazG family protein
OIO74_15270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OIO74_15290	COG0784	Response regulator, receiver
OIO74_15290	COG2205	protein histidine kinase activity
OIO74_15290	COG5002	protein histidine kinase activity
OIO74_15295	COG1024	Enoyl-CoA hydratase
OIO74_15300	COG2084	Dehydrogenase
OIO74_15305	COG3622	Belongs to the hyi family
OIO74_15335	COG0697	spore germination
OIO74_15345	COG2814	Major facilitator Superfamily
OIO74_15350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OIO74_15360	COG0583	DNA-binding transcription factor activity
OIO74_15370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OIO74_15380	COG0084	hydrolase, TatD family'
OIO74_15395	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OIO74_15420	COG2130	NADP-dependent
OIO74_15425	COG1309	transcriptional regulator
OIO74_15435	COG1902	pentaerythritol trinitrate reductase activity
OIO74_15445	COG1979	alcohol dehydrogenase
OIO74_15460	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
OIO74_15475	COG3321	synthase
OIO74_15475	COG0604	alcohol dehydrogenase
OIO74_15480	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OIO74_15485	COG0583	DNA-binding transcription factor activity
OIO74_15490	COG4221	oxidoreductase activity
OIO74_15605	COG0440	acetolactate synthase activity
OIO74_15610	COG0028	Belongs to the TPP enzyme family
OIO74_15635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO74_15640	COG0577	efflux transmembrane transporter activity
OIO74_15640	COG1136	(ABC) transporter
OIO74_15645	COG1538	Outer membrane efflux protein
OIO74_15660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OIO74_15665	COG1162	GTPase activity
OIO74_15675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OIO74_15685	COG2091	lysine biosynthetic process via aminoadipic acid
OIO74_15715	COG1426	Protein conserved in bacteria
OIO74_15750	COG0793	Belongs to the peptidase S41A family
OIO74_15765	COG2267	carboxylic ester hydrolase activity
OIO74_15775	COG1012	belongs to the aldehyde dehydrogenase family
OIO74_15780	COG3265	gluconokinase activity
OIO74_15790	COG0800	Aldolase
OIO74_15800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OIO74_15805	COG0857	belongs to the CobB CobQ family
OIO74_15805	COG0280	phosphate acetyltransferase
OIO74_15810	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
OIO74_15810	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
OIO74_15830	COG0740	serine-type endopeptidase activity
OIO74_15840	COG4774	siderophore transport
OIO74_15850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OIO74_15860	COG2813	Specifically methylates the guanine in position
OIO74_15860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO74_15960	COG0788	formyltetrahydrofolate deformylase activity
OIO74_15985	COG4651	solute:proton antiporter activity
OIO74_15985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO74_16005	COG0724	RNA recognition motif
OIO74_16010	COG0210	DNA helicase
OIO74_16035	COG1733	regulation of RNA biosynthetic process
OIO74_16045	COG2900	Belongs to the SlyX family
OIO74_16050	COG0488	(ABC) transporter
OIO74_16070	COG1280	lysine exporter protein (LysE YggA)
OIO74_16075	COG1560	Kdo2-lipid A biosynthetic process
OIO74_16085	COG1301	dicarboxylic acid transport
OIO74_16140	COG0473	3-isopropylmalate dehydrogenase activity
OIO74_16195	COG0583	DNA-binding transcription factor activity
OIO74_16205	COG0625	glutathione transferase activity
OIO74_16210	COG2378	regulation of single-species biofilm formation
OIO74_16215	COG0546	phosphoglycolate phosphatase activity
OIO74_16225	COG1530	ribonuclease E activity
OIO74_16230	COG0318	PFAM AMP-dependent synthetase and ligase
OIO74_16245	COG0583	DNA-binding transcription factor activity
OIO74_16250	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_16255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OIO74_16265	COG0534	Mate efflux family protein
OIO74_16280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OIO74_16305	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO74_16305	COG0493	'glutamate synthase
OIO74_16315	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
OIO74_16320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO74_16335	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OIO74_16345	COG0644	oxidoreductase
OIO74_16345	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
OIO74_16355	COG0425	Belongs to the sulfur carrier protein TusA family
OIO74_16360	COG4535	Mg2 and Co2 transporter CorC
OIO74_16370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO74_16390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OIO74_16395	COG0475	glutathione-regulated potassium exporter activity
OIO74_16395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO74_16410	COG0484	heat shock protein binding
OIO74_16415	COG0789	Transcriptional regulator
OIO74_16420	COG0598	Magnesium transport protein CorA
OIO74_16435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OIO74_16440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OIO74_16445	COG1074	ATP-dependent DNA helicase activity
OIO74_16450	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OIO74_16470	COG2226	methyltransferase
OIO74_16485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO74_16500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OIO74_16515	COG2111	Na H antiporter
OIO74_16515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OIO74_16520	COG1006	Multisubunit Na H antiporter MnhC subunit
OIO74_16525	COG0651	ATP synthesis coupled electron transport
OIO74_16530	COG1863	multisubunit Na H antiporter MnhE subunit
OIO74_16535	COG2212	antiporter activity
OIO74_16540	COG1320	monovalent cation:proton antiporter activity
OIO74_16555	COG0195	Participates in both transcription termination and antitermination
OIO74_16605	COG0237	dephospho-CoA kinase activity
OIO74_16615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OIO74_16630	COG0497	DNA recombination
OIO74_16640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OIO74_16670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OIO74_16670	COG2169	Transcriptional regulator
OIO74_16675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OIO74_16740	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OIO74_16755	COG0326	Molecular chaperone. Has ATPase activity
OIO74_16770	COG2056	Na+-H+ antiporter family
OIO74_16775	COG0596	Alpha beta hydrolase
OIO74_16870	COG0546	phosphoglycolate phosphatase activity
OIO74_16875	COG1716	ATPase activity
OIO74_16910	COG2826	transposase and inactivated derivatives, IS30 family
OIO74_16935	COG0181	hydroxymethylbilane synthase activity
OIO74_16945	COG3275	phosphorelay sensor kinase activity
OIO74_16965	COG1538	Outer membrane efflux protein
OIO74_16970	COG0697	spore germination
OIO74_16995	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OIO74_17000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OIO74_17005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OIO74_17010	COG0772	Belongs to the SEDS family
OIO74_17035	COG4974	Belongs to the 'phage' integrase family
OIO74_17040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO74_17050	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OIO74_17060	COG2197	response regulator
OIO74_17075	COG0793	Belongs to the peptidase S41A family
OIO74_17080	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OIO74_17085	COG0795	lipopolysaccharide-transporting ATPase activity
OIO74_17125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OIO74_17125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OIO74_17135	COG0004	ammonium transporteR
OIO74_17140	COG0347	Belongs to the P(II) protein family
OIO74_17190	COG0589	response to stress
OIO74_17195	COG0659	secondary active sulfate transmembrane transporter activity
OIO74_17205	COG1002	Type II restriction enzyme, methylase subunits
OIO74_17210	COG1061	Type III restriction enzyme res subunit
OIO74_17245	COG0235	Class ii aldolase
OIO74_17250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO74_17275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OIO74_17290	COG0318	PFAM AMP-dependent synthetase and ligase
OIO74_17300	COG0477	Major facilitator Superfamily
OIO74_17305	COG2860	membrane
OIO74_17310	COG3012	SEC-C Motif Domain Protein
OIO74_17315	COG1253	flavin adenine dinucleotide binding
OIO74_17325	COG2814	Major facilitator Superfamily
OIO74_17335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OIO74_17375	COG0655	NAD(P)H dehydrogenase (quinone) activity
OIO74_17390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OIO74_17460	COG0758	DNA mediated transformation
OIO74_17470	COG0697	spore germination
OIO74_17475	COG1309	transcriptional regulator
OIO74_17490	COG0386	Belongs to the glutathione peroxidase family
OIO74_17555	COG1121	(ABC) transporter
OIO74_17560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OIO74_17565	COG1280	lysine exporter protein (LysE YggA)
OIO74_17570	COG2837	iron assimilation
OIO74_17580	COG0281	malic enzyme
OIO74_17625	COG0519	Catalyzes the synthesis of GMP from XMP
OIO74_17625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OIO74_17630	COG4399	Belongs to the UPF0754 family
OIO74_17635	COG2259	Doxx family
OIO74_17640	COG0586	Pfam SNARE associated Golgi protein
OIO74_17655	COG1192	Involved in chromosome partitioning
OIO74_17665	COG0271	Belongs to the BolA IbaG family
OIO74_17685	COG2267	carboxylic ester hydrolase activity
OIO74_17705	COG3321	synthase
OIO74_17705	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
OIO74_17705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OIO74_17705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OIO74_17710	COG1960	acyl-CoA dehydrogenase activity
OIO74_17720	COG2197	response regulator
OIO74_17730	COG3916	Acyl-homoserine-lactone synthase
OIO74_17735	COG0477	Major facilitator Superfamily
OIO74_17740	COG1024	Enoyl-CoA hydratase
OIO74_17745	COG1024	Enoyl-CoA hydratase
OIO74_17750	COG1960	acyl-CoA dehydrogenase activity
OIO74_17755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO74_17775	COG1113	amino acid transport
OIO74_17780	COG1113	amino acid transport
OIO74_17785	COG0251	oxidation-reduction process
OIO74_17825	COG0564	pseudouridine synthase activity
OIO74_17870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OIO74_17885	COG1802	Transcriptional regulator
OIO74_17895	COG1448	Aminotransferase
OIO74_17900	COG0277	FAD linked oxidase domain protein
OIO74_17910	COG2186	Transcriptional regulator
OIO74_17920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO74_17930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OIO74_17945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OIO74_17950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OIO74_17960	COG0438	transferase activity, transferring glycosyl groups
OIO74_17965	COG0438	transferase activity, transferring glycosyl groups
OIO74_17970	COG0463	Glycosyl transferase, family 2
OIO74_17970	COG1216	Glycosyl transferase, family 2
OIO74_17990	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
OIO74_18000	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OIO74_18030	COG0728	peptidoglycan biosynthetic process
OIO74_18035	COG3023	N-Acetylmuramoyl-L-alanine amidase
OIO74_18095	COG0546	phosphoglycolate phosphatase activity
OIO74_18100	COG1028	Short-chain dehydrogenase reductase Sdr
OIO74_18120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO74_18125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO74_18130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO74_18135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO74_18140	COG1116	anion transmembrane transporter activity
OIO74_18145	COG1309	transcriptional regulator
OIO74_18150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OIO74_18160	COG0196	riboflavin kinase activity
OIO74_18165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OIO74_18175	COG1047	Peptidyl-prolyl cis-trans
OIO74_18215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OIO74_18220	COG0657	acetylesterase activity
OIO74_18240	COG0583	DNA-binding transcription factor activity
OIO74_18270	COG2951	lytic endotransglycosylase activity
OIO74_18275	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OIO74_18290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OIO74_18300	COG0671	phosphoesterase, PA-phosphatase related
OIO74_18305	COG0861	Integral membrane protein TerC family
OIO74_18315	COG0754	glutathionylspermidine amidase activity
OIO74_18325	COG0402	S-adenosylhomocysteine deaminase activity
OIO74_18340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO74_18345	COG1230	cation diffusion facilitator family transporter
OIO74_18360	COG0706	membrane insertase activity
OIO74_18390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO74_18440	COG3586	endonuclease activity
OIO74_18530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OIO74_18550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO74_18730	COG0358	DNA primase activity
OIO74_18790	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OIO74_18830	COG0587	DNA-directed DNA polymerase activity
OIO74_18850	COG0587	DNA-directed DNA polymerase activity
OIO74_18865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OIO74_18865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OIO74_18915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OIO74_18915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OIO74_18920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides