locus-tag	class	description
OIO43_00010	COG0592	DNA-directed DNA polymerase activity
OIO43_00020	COG0187	DNA topoisomerase II activity
OIO43_00030	COG0586	Pfam SNARE associated Golgi protein
OIO43_00035	COG0488	(ABC) transporter
OIO43_00060	COG0596	Alpha beta hydrolase
OIO43_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OIO43_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OIO43_00110	COG0733	neurotransmitter:sodium symporter activity
OIO43_00145	COG0583	DNA-binding transcription factor activity
OIO43_00150	COG2233	PERMEase
OIO43_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO43_00200	COG2814	Major facilitator Superfamily
OIO43_00205	COG0656	L-ascorbic acid biosynthetic process
OIO43_00210	COG0583	DNA-binding transcription factor activity
OIO43_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO43_00230	COG1064	alcohol dehydrogenase
OIO43_00235	COG2818	Glycosylase
OIO43_00250	COG1194	a g-specific adenine glycosylase
OIO43_00270	COG2983	Belongs to the UPF0260 family
OIO43_00275	COG2133	pyrroloquinoline quinone binding
OIO43_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OIO43_00285	COG2116	formate transmembrane transporter activity
OIO43_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO43_00310	COG1335	isochorismatase
OIO43_00315	COG0385	Bile acid
OIO43_00320	COG0534	Mate efflux family protein
OIO43_00325	COG1683	Conserved Protein
OIO43_00345	COG0625	glutathione transferase activity
OIO43_00355	COG1113	amino acid transport
OIO43_00365	COG0523	cobalamin synthesis protein
OIO43_00375	COG2188	Transcriptional regulator
OIO43_00405	COG0010	Belongs to the arginase family
OIO43_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OIO43_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OIO43_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OIO43_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OIO43_00525	COG0534	Mate efflux family protein
OIO43_00530	COG0436	Aminotransferase
OIO43_00535	COG2733	membrane
OIO43_00550	COG2918	glutathione biosynthetic process
OIO43_00565	COG2826	transposase and inactivated derivatives, IS30 family
OIO43_00575	COG3951	Flagellar rod assembly protein muramidase FlgJ
OIO43_00575	COG1705	Flagellar rod assembly protein muramidase FlgJ
OIO43_00615	COG3150	esterase
OIO43_00625	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
OIO43_00635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO43_00645	COG2233	PERMEase
OIO43_00650	COG2351	hydroxyisourate hydrolase activity
OIO43_00685	COG3706	GGDEF domain
OIO43_00700	COG1393	Belongs to the ArsC family
OIO43_00705	COG0708	Exodeoxyribonuclease III
OIO43_00735	COG0189	ligase activity
OIO43_00755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OIO43_00765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OIO43_00780	COG4942	peptidase
OIO43_00790	COG0508	dehydrogenase complex catalyzes the overall conversion of
OIO43_00800	COG2119	membrane
OIO43_00805	COG4774	siderophore transport
OIO43_00810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO43_00810	COG0426	domain, Protein
OIO43_00835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OIO43_00855	COG1902	pentaerythritol trinitrate reductase activity
OIO43_00860	COG1519	Transferase
OIO43_00865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OIO43_00870	COG0668	transmembrane transport
OIO43_00880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO43_00885	COG1335	isochorismatase
OIO43_00890	COG1522	sequence-specific DNA binding
OIO43_00915	COG2205	protein histidine kinase activity
OIO43_00915	COG2198	Histidine kinase
OIO43_00915	COG0784	Response regulator, receiver
OIO43_00920	COG3162	membrane
OIO43_00925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OIO43_00955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OIO43_00960	COG1309	transcriptional regulator
OIO43_00980	COG0351	phosphomethylpyrimidine kinase
OIO43_00980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OIO43_00980	COG0352	thiamine-phosphate diphosphorylase activity
OIO43_00990	COG2826	transposase and inactivated derivatives, IS30 family
OIO43_01000	COG2015	COG2015, Alkyl sulfatase and related hydrolases
OIO43_01010	COG2826	transposase and inactivated derivatives, IS30 family
OIO43_01020	COG2814	Major facilitator Superfamily
OIO43_01035	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OIO43_01045	COG1113	amino acid transport
OIO43_01055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OIO43_01060	COG1012	belongs to the aldehyde dehydrogenase family
OIO43_01070	COG1335	isochorismatase
OIO43_01100	COG2814	Major facilitator Superfamily
OIO43_01105	COG0583	DNA-binding transcription factor activity
OIO43_01125	COG0667	Aldo Keto reductase
OIO43_01160	COG2826	transposase and inactivated derivatives, IS30 family
OIO43_01180	COG1733	regulation of RNA biosynthetic process
OIO43_01185	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO43_01250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OIO43_01290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OIO43_01320	COG0427	acetyl-CoA hydrolase
OIO43_01345	COG0659	secondary active sulfate transmembrane transporter activity
OIO43_01350	COG4221	oxidoreductase activity
OIO43_01355	COG2873	o-acetylhomoserine
OIO43_01360	COG0488	(ABC) transporter
OIO43_01455	COG0833	amino acid
OIO43_01500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OIO43_01505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OIO43_01520	COG2226	methyltransferase
OIO43_01570	COG0070	glutamate synthase
OIO43_01570	COG0067	glutamate synthase
OIO43_01570	COG0069	glutamate synthase activity
OIO43_01575	COG0493	'glutamate synthase
OIO43_01585	COG1704	LemA family
OIO43_01590	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
OIO43_01600	COG4969	Belongs to the N-Me-Phe pilin family
OIO43_01625	COG1061	Type III restriction enzyme res subunit
OIO43_01630	COG1002	Type II restriction enzyme, methylase subunits
OIO43_01655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OIO43_01670	COG0194	GDP metabolic process
OIO43_01720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OIO43_01740	COG5380	lipid catabolic process
OIO43_01745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OIO43_01770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OIO43_01775	COG0277	FAD linked oxidase domain protein
OIO43_01785	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OIO43_01790	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO43_01805	COG1289	transmembrane transporter activity
OIO43_01815	COG0628	permease
OIO43_01820	COG1192	Involved in chromosome partitioning
OIO43_01850	COG0833	amino acid
OIO43_01855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OIO43_01860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OIO43_01870	COG1012	belongs to the aldehyde dehydrogenase family
OIO43_01910	COG0583	DNA-binding transcription factor activity
OIO43_01930	COG0752	glycyl-tRNA synthetase alpha subunit
OIO43_01955	COG0517	IMP dehydrogenase activity
OIO43_01960	COG1983	PspC domain protein
OIO43_01970	COG1960	acyl-CoA dehydrogenase activity
OIO43_01985	COG0408	coproporphyrinogen oxidase activity
OIO43_02005	COG0513	Belongs to the DEAD box helicase family
OIO43_02015	COG1127	ABC transporter
OIO43_02020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OIO43_02030	COG2854	intermembrane phospholipid transfer
OIO43_02040	COG0598	Magnesium transport protein CorA
OIO43_02050	COG0494	nUDIX hydrolase
OIO43_02055	COG1040	competence protein
OIO43_02060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OIO43_02080	COG1946	Acyl-CoA thioesterase
OIO43_02085	COG1301	dicarboxylic acid transport
OIO43_02100	COG1959	2 iron, 2 sulfur cluster binding
OIO43_02105	COG1017	nitric oxide dioxygenase activity
OIO43_02105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO43_02115	COG0433	COG0433 Predicted ATPase
OIO43_02120	COG0626	cystathionine gamma-synthase activity
OIO43_02275	COG1960	acyl-CoA dehydrogenase activity
OIO43_02280	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
OIO43_02310	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
OIO43_02315	COG0339	signal peptide processing
OIO43_02320	COG0557	exoribonuclease II activity
OIO43_02365	COG0179	Fumarylacetoacetate (FAA) hydrolase
OIO43_02370	COG2169	Transcriptional regulator
OIO43_02375	COG0697	spore germination
OIO43_02380	COG1295	ribonuclease BN
OIO43_02415	COG1702	phosphate starvation-inducible protein PhoH
OIO43_02425	COG0739	heme binding
OIO43_02425	COG0741	lytic transglycosylase activity
OIO43_02425	COG1196	nuclear chromosome segregation
OIO43_02455	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OIO43_02460	COG1183	phosphatidylcholine synthase activity
OIO43_02505	COG1960	acyl-CoA dehydrogenase activity
OIO43_02510	COG1309	transcriptional regulator
OIO43_02525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OIO43_02530	COG1960	acyl-CoA dehydrogenase activity
OIO43_02550	COG2969	positive regulation of protein catabolic process
OIO43_02560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OIO43_02570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
OIO43_02575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OIO43_02580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OIO43_02600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OIO43_02610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OIO43_02615	COG1408	metallophosphoesterase
OIO43_02625	COG2199	diguanylate cyclase activity
OIO43_02685	COG1607	acyl-coa hydrolase
OIO43_02720	COG3013	Belongs to the UPF0304 family
OIO43_02800	COG2205	protein histidine kinase activity
OIO43_02815	COG2132	Multicopper oxidase
OIO43_02840	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO43_02890	COG0582	viral genome integration into host DNA
OIO43_02915	COG2350	Protein conserved in bacteria
OIO43_02925	COG0613	PHP domain protein
OIO43_02930	COG3781	membrane
OIO43_02940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OIO43_02945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OIO43_02955	COG1862	Preprotein translocase
OIO43_02995	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OIO43_03010	COG0726	polysaccharide deacetylase
OIO43_03015	COG0438	transferase activity, transferring glycosyl groups
OIO43_03035	COG0438	transferase activity, transferring glycosyl groups
OIO43_03040	COG1216	Glycosyl transferase, family 2
OIO43_03045	COG0438	transferase activity, transferring glycosyl groups
OIO43_03090	COG1960	acyl-CoA dehydrogenase activity
OIO43_03095	COG1960	acyl-CoA dehydrogenase activity
OIO43_03105	COG2205	protein histidine kinase activity
OIO43_03110	COG0745	RESPONSE REGULATOR receiver
OIO43_03115	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OIO43_03135	COG2096	Adenosyltransferase
OIO43_03185	COG0285	dihydrofolate synthase activity
OIO43_03205	COG0450	alkyl hydroperoxide reductase
OIO43_03220	COG0477	Major facilitator Superfamily
OIO43_03225	COG1272	protein, Hemolysin III
OIO43_03265	COG0183	Belongs to the thiolase family
OIO43_03270	COG2207	Transcriptional regulator
OIO43_03290	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO43_03310	COG0183	Belongs to the thiolase family
OIO43_03320	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
OIO43_03320	COG2885	chlorophyll binding
OIO43_03330	COG1690	Belongs to the RtcB family
OIO43_03335	COG0833	amino acid
OIO43_03345	COG2233	PERMEase
OIO43_03350	COG1217	gtp-binding protein TYPA
OIO43_03375	COG2094	Belongs to the DNA glycosylase MPG family
OIO43_03385	COG1902	pentaerythritol trinitrate reductase activity
OIO43_03400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO43_03405	COG0354	folic acid binding
OIO43_03415	COG3189	MarR family transcriptional regulator
OIO43_03420	COG2824	Alkylphosphonate utilization operon protein PhnA
OIO43_03425	COG3422	double-strand break repair
OIO43_03465	COG0840	transmembrane signaling receptor activity
OIO43_03485	COG5510	response to toxic substance
OIO43_03495	COG2832	Protein of unknown function (DUF454)
OIO43_03500	COG1376	ErfK ybiS ycfS ynhG family protein
OIO43_03540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OIO43_03550	COG1289	transmembrane transporter activity
OIO43_03555	COG2814	Major facilitator Superfamily
OIO43_03575	COG1115	amino acid carrier protein
OIO43_03580	COG1752	Esterase of the alpha-beta hydrolase superfamily
OIO43_03585	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OIO43_03590	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
OIO43_03620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OIO43_03630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OIO43_03635	COG1077	Cell shape determining protein MreB Mrl
OIO43_03640	COG1792	Involved in formation and maintenance of cell shape
OIO43_03645	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OIO43_03650	COG0424	maF-like protein
OIO43_03655	COG1530	ribonuclease E activity
OIO43_03665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO43_03675	COG0560	Phosphoserine phosphatase
OIO43_03685	COG2249	NAD(P)H dehydrogenase (quinone) activity
OIO43_03710	COG2207	Transcriptional regulator
OIO43_03730	COG1113	amino acid transport
OIO43_03735	COG2828	Protein conserved in bacteria
OIO43_03740	COG0142	geranyltranstransferase activity
OIO43_03745	COG2315	Protein conserved in bacteria
OIO43_03760	COG1752	Esterase of the alpha-beta hydrolase superfamily
OIO43_03775	COG2826	transposase and inactivated derivatives, IS30 family
OIO43_03785	COG2194	sulfuric ester hydrolase activity
OIO43_03790	COG0745	RESPONSE REGULATOR receiver
OIO43_03795	COG0642	Histidine kinase
OIO43_03805	COG0004	ammonium transporteR
OIO43_03810	COG0583	DNA-binding transcription factor activity
OIO43_03830	COG0525	valine-tRNA ligase activity
OIO43_03840	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_03850	COG0393	Putative heavy-metal-binding
OIO43_03855	COG0393	Putative heavy-metal-binding
OIO43_03860	COG1538	Outer membrane efflux protein
OIO43_03870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO43_03875	COG0671	phosphoesterase, PA-phosphatase related
OIO43_03905	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OIO43_03920	COG1648	precorrin-2 dehydrogenase activity
OIO43_03920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OIO43_03925	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OIO43_03930	COG1733	regulation of RNA biosynthetic process
OIO43_03940	COG0531	amino acid
OIO43_03955	COG0321	lipoyl(octanoyl) transferase activity
OIO43_03960	COG2921	Belongs to the UPF0250 family
OIO43_03995	COG2009	succinate dehydrogenase
OIO43_04000	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OIO43_04005	COG1053	succinate dehydrogenase
OIO43_04010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OIO43_04035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO43_04055	COG2354	Protein conserved in bacteria
OIO43_04060	COG2321	neutral zinc metallopeptidase
OIO43_04080	COG2843	Capsule synthesis protein
OIO43_04095	COG0589	response to stress
OIO43_04115	COG0505	Belongs to the CarA family
OIO43_04140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO43_04145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OIO43_04195	COG0477	Major facilitator Superfamily
OIO43_04200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OIO43_04215	COG1597	lipid kinase activity
OIO43_04220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OIO43_04295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO43_04300	COG0584	glycerophosphoryl diester phosphodiesterase
OIO43_04320	COG0741	lytic transglycosylase activity
OIO43_04340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OIO43_04355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO43_04365	COG3811	Belongs to the UPF0386 family
OIO43_04385	COG2801	Transposase and inactivated derivatives
OIO43_04410	COG0778	Nitroreductase
OIO43_04425	COG1929	Belongs to the glycerate kinase type-1 family
OIO43_04430	COG0243	molybdopterin cofactor binding
OIO43_04435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OIO43_04440	COG3339	Conserved Protein
OIO43_04450	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OIO43_04465	COG1113	amino acid transport
OIO43_04475	COG0019	diaminopimelate decarboxylase activity
OIO43_04485	COG1280	lysine exporter protein (LysE YggA)
OIO43_04490	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OIO43_04520	COG0463	Glycosyl transferase, family 2
OIO43_04540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO43_04575	COG4591	ABC-type transport system involved in lipoprotein release permease component
OIO43_04580	COG1136	(ABC) transporter
OIO43_04585	COG2333	competence protein COMEC
OIO43_04585	COG0658	competence protein
OIO43_04595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OIO43_04595	COG0616	signal peptide processing
OIO43_04600	COG0596	Alpha beta hydrolase
OIO43_04605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OIO43_04615	COG0628	permease
OIO43_04635	COG2826	transposase and inactivated derivatives, IS30 family
OIO43_04660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OIO43_04680	COG0823	Involved in the tonB-independent uptake of proteins
OIO43_04700	COG0824	Thioesterase
OIO43_04705	COG1473	amidohydrolase
OIO43_04725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OIO43_04725	COG0047	phosphoribosylformylglycinamidine synthase activity
OIO43_04730	COG2814	Major facilitator Superfamily
OIO43_04745	COG1024	Enoyl-CoA hydratase
OIO43_04750	COG1051	belongs to the nudix hydrolase family
OIO43_04750	COG1056	cytidyltransferase-related domain
OIO43_04760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OIO43_04775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OIO43_04790	COG4625	pathogenesis
OIO43_04795	COG0583	DNA-binding transcription factor activity
OIO43_04800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OIO43_04805	COG4208	sulfate ABC transporter
OIO43_04810	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OIO43_04820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
OIO43_04825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OIO43_04830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OIO43_04850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OIO43_04860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OIO43_04870	COG0681	Belongs to the peptidase S26 family
OIO43_04885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OIO43_04895	COG1381	Involved in DNA repair and RecF pathway recombination
OIO43_04900	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OIO43_04910	COG4221	oxidoreductase activity
OIO43_04940	COG0436	Aminotransferase
OIO43_04960	COG0556	nucleotide-excision repair
OIO43_05015	COG2070	2-Nitropropane dioxygenase
OIO43_05045	COG1215	transferase activity, transferring glycosyl groups
OIO43_05060	COG0415	Belongs to the DNA photolyase family
OIO43_05070	COG1252	NADH dehydrogenase
OIO43_05075	COG1686	Belongs to the peptidase S11 family
OIO43_05090	COG1187	pseudouridine synthase activity
OIO43_05115	COG0477	Major facilitator Superfamily
OIO43_05120	COG0583	DNA-binding transcription factor activity
OIO43_05125	COG1823	symporter activity
OIO43_05135	COG0612	Peptidase, M16
OIO43_05160	COG0352	thiamine-phosphate diphosphorylase activity
OIO43_05195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO43_05220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OIO43_05225	COG0076	glutamate decarboxylase activity
OIO43_05235	COG1522	sequence-specific DNA binding
OIO43_05240	COG3961	Belongs to the TPP enzyme family
OIO43_05245	COG1113	amino acid transport
OIO43_05250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OIO43_05255	COG0573	inorganic phosphate transmembrane transporter activity
OIO43_05265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OIO43_05270	COG0616	signal peptide processing
OIO43_05305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OIO43_05310	COG1686	Belongs to the peptidase S11 family
OIO43_05335	COG0583	DNA-binding transcription factor activity
OIO43_05340	COG1067	ATP-dependent peptidase activity
OIO43_05365	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OIO43_05385	COG1966	Carbon starvation protein
OIO43_05390	COG2879	small protein
OIO43_05410	COG2801	Transposase and inactivated derivatives
OIO43_05430	COG1741	Belongs to the pirin family
OIO43_05440	COG2964	Protein conserved in bacteria
OIO43_05455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO43_05460	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OIO43_05465	COG4605	iron ion homeostasis
OIO43_05470	COG4604	ABC transporter, ATP-binding protein
OIO43_05475	COG4607	ABC-type enterochelin transport system periplasmic component
OIO43_05480	COG4774	siderophore transport
OIO43_05490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OIO43_05495	COG1021	2,3-dihydroxybenzoate-AMP ligase
OIO43_05500	COG1535	isochorismatase
OIO43_05500	COG3433	isochorismatase activity
OIO43_05510	COG1132	(ABC) transporter
OIO43_05515	COG1132	(ABC) transporter
OIO43_05520	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
OIO43_05525	COG2977	Belongs to the P-Pant transferase superfamily
OIO43_05530	COG1169	isochorismate synthase
OIO43_05545	COG3739	integral membrane protein
OIO43_05565	COG0302	gtp cyclohydrolase
OIO43_05575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OIO43_05605	COG0308	aminopeptidase N
OIO43_05610	COG0512	Glutamine amidotransferase of anthranilate synthase
OIO43_05625	COG0174	glutamine synthetase
OIO43_05635	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OIO43_05670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OIO43_05675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OIO43_05680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OIO43_05700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OIO43_05705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OIO43_05710	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OIO43_05725	COG1960	acyl-CoA dehydrogenase activity
OIO43_05730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OIO43_05735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO43_05745	COG2223	nitrite transmembrane transporter activity
OIO43_05755	COG0024	Methionine aminopeptidase
OIO43_05760	COG0052	Belongs to the universal ribosomal protein uS2 family
OIO43_05775	COG2207	Transcriptional regulator
OIO43_05800	COG2951	lytic endotransglycosylase activity
OIO43_05805	COG0772	Belongs to the SEDS family
OIO43_05820	COG0842	Transport permease protein
OIO43_05825	COG1131	(ABC) transporter
OIO43_05870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO43_05885	COG4215	(ABC) transporter
OIO43_05890	COG4160	amino acid transport
OIO43_05895	COG4598	ABC transporter
OIO43_05905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO43_05910	COG0826	peptidase U32
OIO43_05915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO43_05930	COG1720	tRNA m6t6A37 methyltransferase activity
OIO43_05940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OIO43_05955	COG0642	Histidine kinase
OIO43_05965	COG0494	nUDIX hydrolase
OIO43_05975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OIO43_05980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OIO43_05985	COG3139	Protein of unknown function (DUF1315)
OIO43_05995	COG1301	dicarboxylic acid transport
OIO43_06000	COG1960	acyl-CoA dehydrogenase activity
OIO43_06005	COG2819	hydrolase of the alpha beta superfamily
OIO43_06015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OIO43_06025	COG2195	Cleaves the N-terminal amino acid of tripeptides
OIO43_06030	COG1234	tRNA 3'-trailer cleavage
OIO43_06060	COG2363	Small membrane protein
OIO43_06085	COG0513	Belongs to the DEAD box helicase family
OIO43_06095	COG0778	Nitroreductase
OIO43_06125	COG1286	toxin biosynthetic process
OIO43_06150	COG4783	chaperone-mediated protein folding
OIO43_06155	COG1610	YqeY-like protein
OIO43_06210	COG2831	hemolysin activation secretion protein
OIO43_06215	COG3210	domain, Protein
OIO43_06215	COG3210	domain, Protein
OIO43_06215	COG3210	domain, Protein
OIO43_06280	COG3111	PFAM Bacterial OB fold (BOF) protein
OIO43_06305	COG3243	poly(R)-hydroxyalkanoic acid synthase
OIO43_06310	COG0786	glutamate:sodium symporter activity
OIO43_06320	COG2186	Transcriptional regulator
OIO43_06370	COG0477	Major facilitator Superfamily
OIO43_06400	COG2995	paraquat-inducible protein a
OIO43_06405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OIO43_06405	COG3008	intermembrane lipid transfer
OIO43_06415	COG2351	hydroxyisourate hydrolase activity
OIO43_06455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OIO43_06465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OIO43_06470	COG0642	Histidine kinase
OIO43_06475	COG0745	RESPONSE REGULATOR receiver
OIO43_06495	COG1794	racemase activity, acting on amino acids and derivatives
OIO43_06525	COG1301	dicarboxylic acid transport
OIO43_06535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO43_06540	COG2011	ABC-type metal ion transport system permease component
OIO43_06545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO43_06550	COG1464	Belongs to the NlpA lipoprotein family
OIO43_06555	COG0151	Belongs to the GarS family
OIO43_06560	COG0138	bifunctional purine biosynthesis protein purh
OIO43_06565	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OIO43_06595	COG2308	Evidence 4 Homologs of previously reported genes of
OIO43_06605	COG1305	Transglutaminase-like
OIO43_06615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OIO43_06620	COG0305	Participates in initiation and elongation during chromosome replication
OIO43_06645	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OIO43_06655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OIO43_06660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OIO43_06685	COG1649	PFAM Uncharacterised BCR, COG1649
OIO43_06685	COG0726	polysaccharide deacetylase
OIO43_06690	COG1215	transferase activity, transferring glycosyl groups
OIO43_06695	COG3658	cytochrome
OIO43_06705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO43_06720	COG0583	DNA-binding transcription factor activity
OIO43_06740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO43_06745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO43_06760	COG1960	acyl-CoA dehydrogenase activity
OIO43_06765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO43_06770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO43_06795	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OIO43_06800	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OIO43_06810	COG2205	protein histidine kinase activity
OIO43_06815	COG0745	RESPONSE REGULATOR receiver
OIO43_06820	COG0174	glutamine synthetase
OIO43_06840	COG0729	surface antigen
OIO43_06865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OIO43_06870	COG2814	Major facilitator Superfamily
OIO43_06885	COG0583	DNA-binding transcription factor activity
OIO43_06900	COG1187	pseudouridine synthase activity
OIO43_06920	COG0802	atpase or kinase
OIO43_06925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OIO43_06935	COG1923	regulation of RNA biosynthetic process
OIO43_06940	COG0697	spore germination
OIO43_06955	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO43_06965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OIO43_06970	COG0519	Catalyzes the synthesis of GMP from XMP
OIO43_06970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OIO43_06975	COG4302	ethanolamine ammonia-lyase activity
OIO43_06980	COG4303	Ethanolamine ammonia lyase large subunit
OIO43_06985	COG0531	amino acid
OIO43_07005	COG1454	alcohol dehydrogenase
OIO43_07010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OIO43_07020	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
OIO43_07040	COG0308	aminopeptidase N
OIO43_07080	COG1605	Chorismate mutase
OIO43_07095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OIO43_07110	COG2801	Transposase and inactivated derivatives
OIO43_07120	COG1309	transcriptional regulator
OIO43_07130	COG0668	transmembrane transport
OIO43_07160	COG4773	Receptor
OIO43_07180	COG0488	(ABC) transporter
OIO43_07185	COG0589	response to stress
OIO43_07210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OIO43_07220	COG3135	benzoate transporter
OIO43_07225	COG1522	sequence-specific DNA binding
OIO43_07235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OIO43_07240	COG0583	DNA-binding transcription factor activity
OIO43_07250	COG0183	Belongs to the thiolase family
OIO43_07260	COG2030	dehydratase
OIO43_07290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OIO43_07300	COG0824	Thioesterase
OIO43_07305	COG1454	alcohol dehydrogenase
OIO43_07315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OIO43_07335	COG0069	glutamate synthase activity
OIO43_07465	COG1484	DNA-dependent DNA replication
OIO43_07655	COG2026	Addiction module toxin, RelE StbE family
OIO43_07695	COG0592	DNA-directed DNA polymerase activity
OIO43_07765	COG2814	Major facilitator Superfamily
OIO43_07780	COG0511	ligase activity, forming carbon-carbon bonds
OIO43_07800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO43_07800	COG1116	anion transmembrane transporter activity
OIO43_07805	COG0745	RESPONSE REGULATOR receiver
OIO43_07815	COG2146	nitrite reductase [NAD(P)H] activity
OIO43_07815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO43_07820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO43_07825	COG0243	molybdopterin cofactor binding
OIO43_07835	COG0243	molybdopterin cofactor binding
OIO43_07840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OIO43_07855	COG0315	cyclic pyranopterin monophosphate synthase activity
OIO43_07855	COG0521	Mo-molybdopterin cofactor biosynthetic process
OIO43_07860	COG0303	'Molybdopterin
OIO43_07870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO43_07875	COG0697	spore germination
OIO43_07895	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OIO43_07900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OIO43_07955	COG2204	response regulator
OIO43_07960	COG3852	Histidine kinase
OIO43_07985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OIO43_07990	COG0575	Belongs to the CDS family
OIO43_08005	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OIO43_08025	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO43_08040	COG2137	regulation of response to DNA damage stimulus
OIO43_08050	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OIO43_08055	COG1011	Hydrolase
OIO43_08070	COG2826	transposase and inactivated derivatives, IS30 family
OIO43_08085	COG1522	sequence-specific DNA binding
OIO43_08095	COG1113	amino acid transport
OIO43_08115	COG0659	secondary active sulfate transmembrane transporter activity
OIO43_08120	COG2135	peptidase activity
OIO43_08135	COG3300	MHYT domain
OIO43_08135	COG5001	Diguanylate cyclase
OIO43_08150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OIO43_08150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OIO43_08150	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
OIO43_08155	COG1105	Belongs to the carbohydrate kinase PfkB family
OIO43_08160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OIO43_08160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OIO43_08190	COG0024	Methionine aminopeptidase
OIO43_08195	COG0583	DNA-binding transcription factor activity
OIO43_08205	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OIO43_08210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OIO43_08215	COG0517	IMP dehydrogenase activity
OIO43_08215	COG0516	GMP reductase activity
OIO43_08240	COG0552	protein localization to endoplasmic reticulum
OIO43_08250	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
OIO43_08265	COG4890	Cyd operon protein YbgT
OIO43_08270	COG1294	oxidase, subunit
OIO43_08285	COG1585	Membrane protein implicated in regulation of membrane protease activity
OIO43_08295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OIO43_08300	COG4774	siderophore transport
OIO43_08315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OIO43_08320	COG0569	domain protein
OIO43_08325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OIO43_08355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OIO43_08360	COG0542	response to heat
OIO43_08370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OIO43_08385	COG1902	pentaerythritol trinitrate reductase activity
OIO43_08385	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO43_08430	COG2323	membrane
OIO43_08435	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OIO43_08445	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO43_08450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO43_08455	COG0183	Belongs to the thiolase family
OIO43_08460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OIO43_08465	COG0596	Alpha beta hydrolase
OIO43_08470	COG2271	Major facilitator Superfamily
OIO43_08475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OIO43_08480	COG3485	protocatechuate 3,4-dioxygenase
OIO43_08485	COG3485	protocatechuate 3,4-dioxygenase
OIO43_08490	COG0710	3-dehydroquinate dehydratase activity
OIO43_08495	COG3420	alginic acid biosynthetic process
OIO43_08500	COG3659	wide pore channel activity
OIO43_08505	COG4993	Dehydrogenase
OIO43_08515	COG2391	methyltransferase activity
OIO43_08530	COG1414	Transcriptional regulator
OIO43_08535	COG0583	DNA-binding transcription factor activity
OIO43_08540	COG1960	acyl-CoA dehydrogenase activity
OIO43_08565	COG2814	Major facilitator Superfamily
OIO43_08575	COG0154	amidase activity
OIO43_08595	COG4638	Rieske (2fe-2S)
OIO43_08605	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_08615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO43_08625	COG3733	amine oxidase
OIO43_08635	COG1012	belongs to the aldehyde dehydrogenase family
OIO43_08645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO43_08650	COG0183	Belongs to the thiolase family
OIO43_08655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO43_08660	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO43_08670	COG4829	muconolactone delta-isomerase
OIO43_08675	COG4948	Mandelate Racemase Muconate Lactonizing
OIO43_08680	COG0583	DNA-binding transcription factor activity
OIO43_08690	COG2186	Transcriptional regulator
OIO43_08710	COG1012	belongs to the aldehyde dehydrogenase family
OIO43_08725	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO43_08725	COG1902	pentaerythritol trinitrate reductase activity
OIO43_08765	COG1309	transcriptional regulator
OIO43_08775	COG1335	isochorismatase
OIO43_08780	COG0583	DNA-binding transcription factor activity
OIO43_08790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO43_08790	COG0475	glutathione-regulated potassium exporter activity
OIO43_08800	COG1473	amidohydrolase
OIO43_08815	COG4191	Histidine kinase
OIO43_08850	COG2188	Transcriptional regulator
OIO43_08865	COG0583	DNA-binding transcription factor activity
OIO43_08880	COG1566	PFAM secretion protein HlyD family protein
OIO43_08895	COG1012	belongs to the aldehyde dehydrogenase family
OIO43_08900	COG0129	dihydroxy-acid dehydratase activity
OIO43_08910	COG0583	DNA-binding transcription factor activity
OIO43_08915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OIO43_08925	COG2084	Dehydrogenase
OIO43_08930	COG2207	Transcriptional regulator
OIO43_08945	COG1064	alcohol dehydrogenase
OIO43_08955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OIO43_08960	COG1120	ATPase activity
OIO43_08980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OIO43_09030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OIO43_09070	COG2826	transposase and inactivated derivatives, IS30 family
OIO43_09100	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_09115	COG2207	Transcriptional regulator
OIO43_09125	COG2205	protein histidine kinase activity
OIO43_09145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO43_09150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO43_09165	COG3539	Fimbrial protein
OIO43_09190	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OIO43_09200	COG0753	catalase activity
OIO43_09220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OIO43_09280	COG1535	isochorismatase
OIO43_09280	COG3433	isochorismatase activity
OIO43_09285	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_09290	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OIO43_09295	COG4149	molybdate abc transporter
OIO43_09300	COG0725	ABC transporter, periplasmic molybdate-binding protein
OIO43_09310	COG4638	Rieske (2fe-2S)
OIO43_09315	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
OIO43_09320	COG0543	2 iron, 2 sulfur cluster binding
OIO43_09320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO43_09335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO43_09345	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_09360	COG2207	Transcriptional regulator
OIO43_09365	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_09370	COG2610	gluconate transmembrane transporter activity
OIO43_09380	COG1309	transcriptional regulator
OIO43_09400	COG0583	DNA-binding transcription factor activity
OIO43_09415	COG2031	fatty acid transporter
OIO43_09420	COG0183	Belongs to the thiolase family
OIO43_09425	COG0583	DNA-binding transcription factor activity
OIO43_09430	COG0583	DNA-binding transcription factor activity
OIO43_09445	COG1027	Aspartate ammonia-lyase
OIO43_09455	COG0477	Major facilitator Superfamily
OIO43_09475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO43_09480	COG4521	taurine ABC transporter
OIO43_09495	COG2188	Transcriptional regulator
OIO43_09505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OIO43_09510	COG1733	regulation of RNA biosynthetic process
OIO43_09515	COG3708	Transcriptional regulator
OIO43_09515	COG2207	Transcriptional regulator
OIO43_09530	COG0730	response to heat
OIO43_09555	COG3781	membrane
OIO43_09560	COG1063	alcohol dehydrogenase
OIO43_09570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OIO43_09575	COG0508	dehydrogenase complex catalyzes the overall conversion of
OIO43_09580	COG0022	dehydrogenase e1 component
OIO43_09585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OIO43_09590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OIO43_09605	COG3706	GGDEF domain
OIO43_09620	COG0133	tryptophan synthase activity
OIO43_09630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OIO43_09665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OIO43_09690	COG2226	methyltransferase
OIO43_09745	COG0842	Transport permease protein
OIO43_09750	COG0842	Transport permease protein
OIO43_09755	COG1131	(ABC) transporter
OIO43_09770	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OIO43_09775	COG4773	Receptor
OIO43_09795	COG0730	response to heat
OIO43_09800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OIO43_09815	COG0406	alpha-ribazole phosphatase activity
OIO43_09820	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OIO43_09835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OIO43_09865	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OIO43_09875	COG4264	IucA IucC family
OIO43_09880	COG4264	IucA IucC family
OIO43_09900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OIO43_09915	COG1960	acyl-CoA dehydrogenase activity
OIO43_09920	COG1960	acyl-CoA dehydrogenase activity
OIO43_09925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OIO43_09930	COG2207	Transcriptional regulator
OIO43_09935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OIO43_09940	COG0776	regulation of translation
OIO43_09965	COG0822	iron-sulfur transferase activity
OIO43_09970	COG0316	Belongs to the HesB IscA family
OIO43_10000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OIO43_10020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OIO43_10025	COG0702	epimerase
OIO43_10060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OIO43_10070	COG0339	signal peptide processing
OIO43_10130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OIO43_10135	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OIO43_10165	COG0776	regulation of translation
OIO43_10230	COG0084	hydrolase, TatD family'
OIO43_10250	COG1663	tetraacyldisaccharide 4'-kinase activity
OIO43_10255	COG1132	(ABC) transporter
OIO43_10265	COG0811	peptide transport
OIO43_10270	COG1475	DNA binding
OIO43_10275	COG1192	Involved in chromosome partitioning
OIO43_10285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OIO43_10300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OIO43_10305	COG0191	fructose-bisphosphate aldolase activity
OIO43_10325	COG0424	maF-like protein
OIO43_10330	COG2850	peptidyl-arginine hydroxylation
OIO43_10340	COG0640	Transcriptional regulator
OIO43_10350	COG3619	membrane
OIO43_10355	COG3122	Protein conserved in bacteria
OIO43_10360	COG1132	(ABC) transporter
OIO43_10380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OIO43_10385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OIO43_10395	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OIO43_10395	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OIO43_10395	COG0506	proline dehydrogenase activity
OIO43_10400	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
OIO43_10415	COG3698	Phosphodiester glycosidase
OIO43_10425	COG2353	YceI-like domain
OIO43_10435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OIO43_10480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OIO43_10480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OIO43_10505	COG3539	Fimbrial protein
OIO43_10510	COG3121	Chaperone
OIO43_10535	COG0697	spore germination
OIO43_10545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OIO43_10555	COG0583	DNA-binding transcription factor activity
OIO43_10615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OIO43_10615	COG0784	Response regulator, receiver
OIO43_10620	COG0582	viral genome integration into host DNA
OIO43_10630	COG1309	transcriptional regulator
OIO43_10645	COG1522	sequence-specific DNA binding
OIO43_10655	COG1126	abc transporter atp-binding protein
OIO43_10660	COG0765	amino acid transport
OIO43_10665	COG0765	amino acid transport
OIO43_10695	COG1464	Belongs to the NlpA lipoprotein family
OIO43_10705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO43_10710	COG2011	ABC-type metal ion transport system permease component
OIO43_10715	COG0012	GTP binding
OIO43_10740	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OIO43_10780	COG0386	Belongs to the glutathione peroxidase family
OIO43_10790	COG0436	Aminotransferase
OIO43_10795	COG1301	dicarboxylic acid transport
OIO43_10830	COG3634	alkyl hydroperoxide reductase activity
OIO43_10845	COG0583	DNA-binding transcription factor activity
OIO43_10850	COG0798	PFAM Bile acid sodium symporter
OIO43_10855	COG0640	Transcriptional regulator
OIO43_10870	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
OIO43_10880	COG0583	DNA-binding transcription factor activity
OIO43_10890	COG1953	Uracil, thiamine, allantoin
OIO43_10900	COG2175	clavaminate synthase activity
OIO43_10905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO43_10910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
OIO43_10915	COG4521	taurine ABC transporter
OIO43_10925	COG0477	Major facilitator Superfamily
OIO43_10945	COG1271	oxidase subunit
OIO43_10950	COG1294	oxidase, subunit
OIO43_10960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OIO43_10980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OIO43_11000	COG3052	prosthetic group binding
OIO43_11005	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
OIO43_11015	COG0583	DNA-binding transcription factor activity
OIO43_11025	COG2814	Major facilitator Superfamily
OIO43_11045	COG1346	cytolysis
OIO43_11055	COG0583	DNA-binding transcription factor activity
OIO43_11060	COG0625	glutathione transferase activity
OIO43_11065	COG0625	glutathione transferase activity
OIO43_11070	COG0583	DNA-binding transcription factor activity
OIO43_11085	COG1045	serine acetyltransferase
OIO43_11090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OIO43_11095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OIO43_11100	COG1280	lysine exporter protein (LysE YggA)
OIO43_11115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO43_11120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OIO43_11125	COG1126	abc transporter atp-binding protein
OIO43_11130	COG0765	amino acid transport
OIO43_11135	COG0765	amino acid transport
OIO43_11155	COG0784	Response regulator, receiver
OIO43_11155	COG2205	protein histidine kinase activity
OIO43_11175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OIO43_11195	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_11215	COG2826	transposase and inactivated derivatives, IS30 family
OIO43_11250	COG0583	DNA-binding transcription factor activity
OIO43_11270	COG0318	PFAM AMP-dependent synthetase and ligase
OIO43_11275	COG1309	transcriptional regulator
OIO43_11280	COG1960	acyl-CoA dehydrogenase activity
OIO43_11285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OIO43_11290	COG1024	Enoyl-CoA hydratase
OIO43_11295	COG4770	biotin carboxylase activity
OIO43_11305	COG0583	DNA-binding transcription factor activity
OIO43_11320	COG1960	acyl-CoA dehydrogenase activity
OIO43_11330	COG2814	Major facilitator Superfamily
OIO43_11340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OIO43_11345	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OIO43_11350	COG2814	Major facilitator Superfamily
OIO43_11355	COG1960	acyl-CoA dehydrogenase activity
OIO43_11360	COG1024	Enoyl-CoA hydratase
OIO43_11365	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_11370	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO43_11375	COG0183	Belongs to the thiolase family
OIO43_11385	COG2814	Major facilitator Superfamily
OIO43_11395	COG1024	Enoyl-CoA hydratase
OIO43_11410	COG1960	acyl-CoA dehydrogenase activity
OIO43_11415	COG2814	Major facilitator Superfamily
OIO43_11420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OIO43_11425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OIO43_11440	COG3842	ATPase activity
OIO43_11445	COG1840	ABC-type Fe3 transport system, periplasmic component
OIO43_11455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO43_11460	COG1414	Transcriptional regulator
OIO43_11470	COG0583	DNA-binding transcription factor activity
OIO43_11475	COG3038	cytochrome b561
OIO43_11480	COG0753	catalase activity
OIO43_11485	COG2271	Major facilitator Superfamily
OIO43_11490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OIO43_11495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OIO43_11510	COG2207	Transcriptional regulator
OIO43_11550	COG2050	protein possibly involved in aromatic compounds catabolism
OIO43_11560	COG3327	negative regulation of DNA-templated transcription, initiation
OIO43_11565	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
OIO43_11570	COG0183	Belongs to the thiolase family
OIO43_11575	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO43_11580	COG1024	Enoyl-CoA hydratase
OIO43_11585	COG1024	Enoyl-CoA hydratase
OIO43_11590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO43_11595	COG2151	metal-sulfur cluster biosynthetic enzyme
OIO43_11600	COG3396	Phenylacetate-CoA oxygenase
OIO43_11605	COG3460	Phenylacetate-CoA oxygenase
OIO43_11610	COG3396	Phenylacetate-CoA oxygenase
OIO43_11615	COG1012	belongs to the aldehyde dehydrogenase family
OIO43_11615	COG2030	dehydratase
OIO43_11620	COG1760	l-serine dehydratase
OIO43_11625	COG0531	amino acid
OIO43_11630	COG1012	belongs to the aldehyde dehydrogenase family
OIO43_11675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO43_11705	COG1309	transcriptional regulator
OIO43_11730	COG0038	chloride channel
OIO43_11735	COG4770	biotin carboxylase activity
OIO43_11755	COG1914	H( )-stimulated, divalent metal cation uptake system
OIO43_11790	COG1250	3-hydroxyacyl-CoA dehydrogenase
OIO43_11825	COG2801	Transposase and inactivated derivatives
OIO43_11830	COG1560	Kdo2-lipid A biosynthetic process
OIO43_11840	COG5006	permease, DMT superfamily
OIO43_11845	COG1522	sequence-specific DNA binding
OIO43_11860	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OIO43_11870	COG4122	O-methyltransferase activity
OIO43_11905	COG1137	ATPase activity
OIO43_11910	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OIO43_11920	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OIO43_11925	COG0517	IMP dehydrogenase activity
OIO43_11925	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OIO43_11960	COG2814	Major facilitator Superfamily
OIO43_11995	COG1278	Cold shock
OIO43_12000	COG1280	lysine exporter protein (LysE YggA)
OIO43_12030	COG1570	exodeoxyribonuclease VII activity
OIO43_12080	COG0583	DNA-binding transcription factor activity
OIO43_12090	COG4638	Rieske (2fe-2S)
OIO43_12095	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
OIO43_12100	COG0633	Ferredoxin
OIO43_12100	COG0543	2 iron, 2 sulfur cluster binding
OIO43_12105	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_12110	COG3135	benzoate transporter
OIO43_12115	COG2814	Major facilitator Superfamily
OIO43_12130	COG1643	Atp-dependent helicase
OIO43_12135	COG0450	alkyl hydroperoxide reductase
OIO43_12145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OIO43_12155	COG3634	alkyl hydroperoxide reductase activity
OIO43_12175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OIO43_12180	COG0625	glutathione transferase activity
OIO43_12190	COG2885	chlorophyll binding
OIO43_12225	COG0542	response to heat
OIO43_12240	COG1765	OsmC-like protein
OIO43_12255	COG0667	Aldo Keto reductase
OIO43_12270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OIO43_12280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OIO43_12400	COG1598	PFAM Uncharacterised protein family UPF0150
OIO43_12630	COG0527	aspartate kinase activity
OIO43_12640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OIO43_12650	COG3038	cytochrome b561
OIO43_12655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OIO43_12660	COG2252	PERMEase
OIO43_12670	COG2072	flavoprotein involved in K transport
OIO43_12685	COG1741	Belongs to the pirin family
OIO43_12690	COG1309	transcriptional regulator
OIO43_12700	COG0300	oxidoreductase activity
OIO43_12705	COG2072	flavoprotein involved in K transport
OIO43_12710	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
OIO43_12755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OIO43_12770	COG2814	Major facilitator Superfamily
OIO43_12775	COG1024	Enoyl-CoA hydratase
OIO43_12780	COG1012	belongs to the aldehyde dehydrogenase family
OIO43_12790	COG1960	acyl-CoA dehydrogenase activity
OIO43_12815	COG2186	Transcriptional regulator
OIO43_12820	COG1012	belongs to the aldehyde dehydrogenase family
OIO43_12830	COG4948	Mandelate Racemase Muconate Lactonizing
OIO43_12835	COG2271	Major facilitator Superfamily
OIO43_12840	COG2721	sulfolactate sulfo-lyase activity
OIO43_12845	COG0697	spore germination
OIO43_12860	COG1113	amino acid transport
OIO43_12880	COG1012	belongs to the aldehyde dehydrogenase family
OIO43_12900	COG0531	amino acid
OIO43_12910	COG1113	amino acid transport
OIO43_12945	COG3209	COG3209 Rhs family protein
OIO43_12965	COG2801	Transposase and inactivated derivatives
OIO43_13005	COG1902	pentaerythritol trinitrate reductase activity
OIO43_13005	COG0446	pyridine nucleotide-disulphide oxidoreductase
OIO43_13015	COG4251	negative regulation of phosphorylation
OIO43_13015	COG3706	GGDEF domain
OIO43_13015	COG2203	Gaf domain
OIO43_13015	COG5001	Diguanylate cyclase
OIO43_13025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO43_13045	COG4172	Belongs to the ABC transporter superfamily
OIO43_13050	COG4239	(ABC) transporter, permease
OIO43_13055	COG4174	ABC transporter (Permease)
OIO43_13065	COG1388	LysM domain
OIO43_13065	COG0741	lytic transglycosylase activity
OIO43_13065	COG1388	LysM domain
OIO43_13065	COG0741	lytic transglycosylase activity
OIO43_13070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO43_13110	COG0583	DNA-binding transcription factor activity
OIO43_13115	COG1279	arginine transmembrane transporter activity
OIO43_13135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO43_13140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO43_13145	COG0006	proline dipeptidase activity
OIO43_13185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OIO43_13220	COG3384	dioxygenase
OIO43_13230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OIO43_13235	COG2878	Part of a membrane complex involved in electron transport
OIO43_13240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OIO43_13265	COG0768	penicillin binding
OIO43_13270	COG0742	ribosomal rna small subunit methyltransferase
OIO43_13285	COG0830	nickel cation binding
OIO43_13295	COG0804	urea catabolic process
OIO43_13335	COG1253	flavin adenine dinucleotide binding
OIO43_13340	COG2851	Citrate transporter
OIO43_13390	COG1773	rubredoxin
OIO43_13395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OIO43_13405	COG0583	DNA-binding transcription factor activity
OIO43_13435	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
OIO43_13440	COG4181	ATPase activity
OIO43_13485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OIO43_13505	COG0306	phosphate transporter
OIO43_13515	COG3958	Transketolase
OIO43_13520	COG3959	Transketolase, thiamine diphosphate binding domain
OIO43_13525	COG2271	Major facilitator Superfamily
OIO43_13530	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_13535	COG0583	DNA-binding transcription factor activity
OIO43_13550	COG2223	nitrite transmembrane transporter activity
OIO43_13555	COG2207	Transcriptional regulator
OIO43_13560	COG2066	Belongs to the glutaminase family
OIO43_13565	COG0242	peptide deformylase activity
OIO43_13570	COG0477	Major facilitator Superfamily
OIO43_13580	COG0028	Belongs to the TPP enzyme family
OIO43_13595	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_13600	COG2267	carboxylic ester hydrolase activity
OIO43_13610	COG2271	Major facilitator Superfamily
OIO43_13625	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_13645	COG1414	Transcriptional regulator
OIO43_13660	COG1024	Enoyl-CoA hydratase
OIO43_13670	COG1215	transferase activity, transferring glycosyl groups
OIO43_13675	COG0726	polysaccharide deacetylase
OIO43_13675	COG1649	PFAM Uncharacterised BCR, COG1649
OIO43_13685	COG4681	YaeQ
OIO43_13695	COG0523	cobalamin synthesis protein
OIO43_13705	COG1607	acyl-coa hydrolase
OIO43_13715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO43_13720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OIO43_13725	COG1309	transcriptional regulator
OIO43_13750	COG2040	homocysteine
OIO43_13755	COG0531	amino acid
OIO43_13780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO43_13785	COG0477	Major facilitator Superfamily
OIO43_13830	COG2826	transposase and inactivated derivatives, IS30 family
OIO43_13845	COG0405	Gamma-glutamyltransferase
OIO43_13850	COG2814	Major facilitator Superfamily
OIO43_13860	COG2050	protein possibly involved in aromatic compounds catabolism
OIO43_13875	COG1090	epimerase
OIO43_13895	COG0420	3'-5' exonuclease activity
OIO43_13920	COG0735	belongs to the Fur family
OIO43_13925	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OIO43_13945	COG0121	glutamine amidotransferase
OIO43_13960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO43_13970	COG0210	DNA helicase
OIO43_13975	COG2885	chlorophyll binding
OIO43_13980	COG0204	Acyl-transferase
OIO43_13995	COG2894	cell division
OIO43_14015	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OIO43_14015	COG1674	ftsk spoiiie
OIO43_14020	COG0492	ferredoxin-NADP+ reductase activity
OIO43_14025	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OIO43_14035	COG0456	acetyltransferase
OIO43_14080	COG1981	membrane
OIO43_14095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OIO43_14095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OIO43_14115	COG1012	belongs to the aldehyde dehydrogenase family
OIO43_14125	COG0657	acetylesterase activity
OIO43_14135	COG0473	3-isopropylmalate dehydrogenase activity
OIO43_14140	COG0583	DNA-binding transcription factor activity
OIO43_14160	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO43_14185	COG0564	pseudouridine synthase activity
OIO43_14195	COG0358	DNA primase activity
OIO43_14210	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OIO43_14240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OIO43_14270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OIO43_14280	COG0351	phosphomethylpyrimidine kinase
OIO43_14280	COG0352	thiamine-phosphate diphosphorylase activity
OIO43_14280	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OIO43_14285	COG1652	LysM domain
OIO43_14310	COG1399	metal-binding, possibly nucleic acid-binding protein
OIO43_14315	COG3101	peptidyl-lysine hydroxylation
OIO43_14320	COG0009	L-threonylcarbamoyladenylate synthase
OIO43_14325	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OIO43_14330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OIO43_14345	COG4106	trans-aconitate 2-methyltransferase activity
OIO43_14360	COG0596	Alpha beta hydrolase
OIO43_14360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO43_14360	COG2226	methyltransferase
OIO43_14365	COG1877	trehalose-phosphatase activity
OIO43_14370	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
OIO43_14375	COG2223	nitrite transmembrane transporter activity
OIO43_14395	COG1196	nuclear chromosome segregation
OIO43_14405	COG0730	response to heat
OIO43_14420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OIO43_14480	COG0489	protein tyrosine kinase activity
OIO43_14490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO43_14490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO43_14520	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OIO43_14525	COG2081	HI0933 family
OIO43_14535	COG0668	transmembrane transport
OIO43_14555	COG0583	DNA-binding transcription factor activity
OIO43_14580	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OIO43_14585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OIO43_14615	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OIO43_14655	COG0745	RESPONSE REGULATOR receiver
OIO43_14675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OIO43_14695	COG5290	Psort location Cytoplasmic, score
OIO43_14705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OIO43_14720	COG0583	DNA-binding transcription factor activity
OIO43_14730	COG0583	DNA-binding transcription factor activity
OIO43_14745	COG0583	DNA-binding transcription factor activity
OIO43_14750	COG1053	succinate dehydrogenase
OIO43_14765	COG1309	transcriptional regulator
OIO43_14770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OIO43_14775	COG2814	Major facilitator Superfamily
OIO43_14780	COG1960	acyl-CoA dehydrogenase activity
OIO43_14785	COG0583	DNA-binding transcription factor activity
OIO43_14790	COG1063	alcohol dehydrogenase
OIO43_14820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OIO43_14825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OIO43_14830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OIO43_14850	COG2132	Multicopper oxidase
OIO43_14860	COG0561	phosphatase activity
OIO43_14865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OIO43_14890	COG1214	PFAM Peptidase M22, glycoprotease
OIO43_14925	COG2826	transposase and inactivated derivatives, IS30 family
OIO43_14960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OIO43_14965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OIO43_14970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OIO43_15030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OIO43_15040	COG1846	Transcriptional regulator
OIO43_15045	COG1764	response to oxidative stress
OIO43_15085	COG0037	tRNA processing
OIO43_15095	COG0248	Ppx GppA phosphatase
OIO43_15125	COG0072	phenylalanine-tRNA ligase activity
OIO43_15170	COG1238	metal cluster binding
OIO43_15175	COG0625	glutathione transferase activity
OIO43_15190	COG0318	PFAM AMP-dependent synthetase and ligase
OIO43_15195	COG3028	Belongs to the UPF0307 family
OIO43_15200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OIO43_15220	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OIO43_15225	COG0617	tRNA 3'-terminal CCA addition
OIO43_15230	COG1555	photosystem II stabilization
OIO43_15235	COG3956	TIGRFAM MazG family protein
OIO43_15245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OIO43_15265	COG0784	Response regulator, receiver
OIO43_15265	COG2205	protein histidine kinase activity
OIO43_15265	COG5002	protein histidine kinase activity
OIO43_15270	COG1024	Enoyl-CoA hydratase
OIO43_15275	COG2084	Dehydrogenase
OIO43_15280	COG3622	Belongs to the hyi family
OIO43_15310	COG0697	spore germination
OIO43_15320	COG2814	Major facilitator Superfamily
OIO43_15325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OIO43_15335	COG0583	DNA-binding transcription factor activity
OIO43_15345	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OIO43_15355	COG0084	hydrolase, TatD family'
OIO43_15370	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OIO43_15395	COG2130	NADP-dependent
OIO43_15400	COG1309	transcriptional regulator
OIO43_15410	COG1902	pentaerythritol trinitrate reductase activity
OIO43_15420	COG1979	alcohol dehydrogenase
OIO43_15435	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
OIO43_15450	COG0604	alcohol dehydrogenase
OIO43_15450	COG3321	synthase
OIO43_15455	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OIO43_15460	COG0583	DNA-binding transcription factor activity
OIO43_15465	COG4221	oxidoreductase activity
OIO43_15580	COG0440	acetolactate synthase activity
OIO43_15585	COG0028	Belongs to the TPP enzyme family
OIO43_15610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OIO43_15615	COG0577	efflux transmembrane transporter activity
OIO43_15615	COG1136	(ABC) transporter
OIO43_15620	COG1538	Outer membrane efflux protein
OIO43_15635	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OIO43_15640	COG1162	GTPase activity
OIO43_15650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OIO43_15660	COG2091	lysine biosynthetic process via aminoadipic acid
OIO43_15690	COG1426	Protein conserved in bacteria
OIO43_15725	COG0793	Belongs to the peptidase S41A family
OIO43_15740	COG2267	carboxylic ester hydrolase activity
OIO43_15750	COG1012	belongs to the aldehyde dehydrogenase family
OIO43_15755	COG3265	gluconokinase activity
OIO43_15765	COG0800	Aldolase
OIO43_15775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OIO43_15780	COG0280	phosphate acetyltransferase
OIO43_15780	COG0857	belongs to the CobB CobQ family
OIO43_15785	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
OIO43_15785	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
OIO43_15805	COG0740	serine-type endopeptidase activity
OIO43_15815	COG4774	siderophore transport
OIO43_15825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OIO43_15835	COG2813	Specifically methylates the guanine in position
OIO43_15835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OIO43_15935	COG0788	formyltetrahydrofolate deformylase activity
OIO43_15960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO43_15960	COG4651	solute:proton antiporter activity
OIO43_15980	COG0724	RNA recognition motif
OIO43_15985	COG0210	DNA helicase
OIO43_16010	COG1733	regulation of RNA biosynthetic process
OIO43_16020	COG2900	Belongs to the SlyX family
OIO43_16025	COG0488	(ABC) transporter
OIO43_16045	COG1280	lysine exporter protein (LysE YggA)
OIO43_16050	COG1560	Kdo2-lipid A biosynthetic process
OIO43_16060	COG1301	dicarboxylic acid transport
OIO43_16115	COG0473	3-isopropylmalate dehydrogenase activity
OIO43_16170	COG0583	DNA-binding transcription factor activity
OIO43_16180	COG0625	glutathione transferase activity
OIO43_16185	COG2378	regulation of single-species biofilm formation
OIO43_16190	COG0546	phosphoglycolate phosphatase activity
OIO43_16200	COG1530	ribonuclease E activity
OIO43_16205	COG0318	PFAM AMP-dependent synthetase and ligase
OIO43_16220	COG0583	DNA-binding transcription factor activity
OIO43_16225	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_16230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OIO43_16240	COG0534	Mate efflux family protein
OIO43_16255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OIO43_16280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OIO43_16280	COG0493	'glutamate synthase
OIO43_16290	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
OIO43_16295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OIO43_16310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OIO43_16320	COG0644	oxidoreductase
OIO43_16320	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
OIO43_16330	COG0425	Belongs to the sulfur carrier protein TusA family
OIO43_16335	COG4535	Mg2 and Co2 transporter CorC
OIO43_16345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OIO43_16365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OIO43_16370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OIO43_16370	COG0475	glutathione-regulated potassium exporter activity
OIO43_16385	COG0484	heat shock protein binding
OIO43_16390	COG0789	Transcriptional regulator
OIO43_16395	COG0598	Magnesium transport protein CorA
OIO43_16410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OIO43_16415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OIO43_16420	COG1074	ATP-dependent DNA helicase activity
OIO43_16425	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OIO43_16445	COG2226	methyltransferase
OIO43_16460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OIO43_16475	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OIO43_16490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OIO43_16490	COG2111	Na H antiporter
OIO43_16495	COG1006	Multisubunit Na H antiporter MnhC subunit
OIO43_16500	COG0651	ATP synthesis coupled electron transport
OIO43_16505	COG1863	multisubunit Na H antiporter MnhE subunit
OIO43_16510	COG2212	antiporter activity
OIO43_16515	COG1320	monovalent cation:proton antiporter activity
OIO43_16530	COG0195	Participates in both transcription termination and antitermination
OIO43_16580	COG0237	dephospho-CoA kinase activity
OIO43_16590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OIO43_16605	COG0497	DNA recombination
OIO43_16615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OIO43_16645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OIO43_16645	COG2169	Transcriptional regulator
OIO43_16650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OIO43_16715	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OIO43_16730	COG0326	Molecular chaperone. Has ATPase activity
OIO43_16745	COG2056	Na+-H+ antiporter family
OIO43_16750	COG0596	Alpha beta hydrolase
OIO43_16845	COG0546	phosphoglycolate phosphatase activity
OIO43_16850	COG1716	ATPase activity
OIO43_16880	COG2826	transposase and inactivated derivatives, IS30 family
OIO43_16905	COG0181	hydroxymethylbilane synthase activity
OIO43_16915	COG3275	phosphorelay sensor kinase activity
OIO43_16935	COG1538	Outer membrane efflux protein
OIO43_16940	COG0697	spore germination
OIO43_16965	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OIO43_16970	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OIO43_16975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OIO43_16980	COG0772	Belongs to the SEDS family
OIO43_17005	COG4974	Belongs to the 'phage' integrase family
OIO43_17010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO43_17020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OIO43_17030	COG2197	response regulator
OIO43_17045	COG0793	Belongs to the peptidase S41A family
OIO43_17050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OIO43_17055	COG0795	lipopolysaccharide-transporting ATPase activity
OIO43_17095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OIO43_17095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OIO43_17105	COG0004	ammonium transporteR
OIO43_17110	COG0347	Belongs to the P(II) protein family
OIO43_17160	COG0589	response to stress
OIO43_17165	COG0659	secondary active sulfate transmembrane transporter activity
OIO43_17175	COG1002	Type II restriction enzyme, methylase subunits
OIO43_17180	COG1061	Type III restriction enzyme res subunit
OIO43_17215	COG0235	Class ii aldolase
OIO43_17220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OIO43_17245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OIO43_17260	COG0318	PFAM AMP-dependent synthetase and ligase
OIO43_17270	COG0477	Major facilitator Superfamily
OIO43_17275	COG2860	membrane
OIO43_17280	COG3012	SEC-C Motif Domain Protein
OIO43_17285	COG1253	flavin adenine dinucleotide binding
OIO43_17295	COG2814	Major facilitator Superfamily
OIO43_17305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OIO43_17345	COG0655	NAD(P)H dehydrogenase (quinone) activity
OIO43_17360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OIO43_17430	COG0758	DNA mediated transformation
OIO43_17440	COG0697	spore germination
OIO43_17445	COG1309	transcriptional regulator
OIO43_17460	COG0386	Belongs to the glutathione peroxidase family
OIO43_17525	COG1121	(ABC) transporter
OIO43_17530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OIO43_17535	COG1280	lysine exporter protein (LysE YggA)
OIO43_17540	COG2837	iron assimilation
OIO43_17550	COG0281	malic enzyme
OIO43_17595	COG0519	Catalyzes the synthesis of GMP from XMP
OIO43_17595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OIO43_17600	COG4399	Belongs to the UPF0754 family
OIO43_17605	COG2259	Doxx family
OIO43_17610	COG0586	Pfam SNARE associated Golgi protein
OIO43_17625	COG1192	Involved in chromosome partitioning
OIO43_17635	COG0271	Belongs to the BolA IbaG family
OIO43_17655	COG2267	carboxylic ester hydrolase activity
OIO43_17675	COG3321	synthase
OIO43_17675	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
OIO43_17675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OIO43_17675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OIO43_17680	COG1960	acyl-CoA dehydrogenase activity
OIO43_17690	COG2197	response regulator
OIO43_17700	COG3916	Acyl-homoserine-lactone synthase
OIO43_17705	COG0477	Major facilitator Superfamily
OIO43_17710	COG1024	Enoyl-CoA hydratase
OIO43_17715	COG1024	Enoyl-CoA hydratase
OIO43_17720	COG1960	acyl-CoA dehydrogenase activity
OIO43_17725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OIO43_17745	COG1113	amino acid transport
OIO43_17750	COG1113	amino acid transport
OIO43_17755	COG0251	oxidation-reduction process
OIO43_17795	COG0564	pseudouridine synthase activity
OIO43_17840	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OIO43_17855	COG1802	Transcriptional regulator
OIO43_17865	COG1448	Aminotransferase
OIO43_17870	COG0277	FAD linked oxidase domain protein
OIO43_17880	COG2186	Transcriptional regulator
OIO43_17890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OIO43_17900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OIO43_17915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OIO43_17920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OIO43_17930	COG0438	transferase activity, transferring glycosyl groups
OIO43_17935	COG0438	transferase activity, transferring glycosyl groups
OIO43_17940	COG0463	Glycosyl transferase, family 2
OIO43_17940	COG1216	Glycosyl transferase, family 2
OIO43_17960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
OIO43_17970	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OIO43_18000	COG0728	peptidoglycan biosynthetic process
OIO43_18005	COG3023	N-Acetylmuramoyl-L-alanine amidase
OIO43_18065	COG0546	phosphoglycolate phosphatase activity
OIO43_18070	COG1028	Short-chain dehydrogenase reductase Sdr
OIO43_18090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO43_18095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OIO43_18100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OIO43_18105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OIO43_18110	COG1116	anion transmembrane transporter activity
OIO43_18115	COG1309	transcriptional regulator
OIO43_18120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OIO43_18130	COG0196	riboflavin kinase activity
OIO43_18135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OIO43_18145	COG1047	Peptidyl-prolyl cis-trans
OIO43_18185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OIO43_18190	COG0657	acetylesterase activity
OIO43_18210	COG0583	DNA-binding transcription factor activity
OIO43_18240	COG2951	lytic endotransglycosylase activity
OIO43_18245	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OIO43_18260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OIO43_18270	COG0671	phosphoesterase, PA-phosphatase related
OIO43_18275	COG0861	Integral membrane protein TerC family
OIO43_18285	COG0754	glutathionylspermidine amidase activity
OIO43_18295	COG0402	S-adenosylhomocysteine deaminase activity
OIO43_18310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OIO43_18315	COG1230	cation diffusion facilitator family transporter
OIO43_18330	COG0706	membrane insertase activity
OIO43_18360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OIO43_18410	COG3586	endonuclease activity
OIO43_18495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OIO43_18515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OIO43_18695	COG0358	DNA primase activity
OIO43_18755	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OIO43_18795	COG0587	DNA-directed DNA polymerase activity
OIO43_18815	COG0587	DNA-directed DNA polymerase activity
OIO43_18830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OIO43_18830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OIO43_18880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OIO43_18880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OIO43_18885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides