locus-tag	class	description
H1I72_00010	COG0592	DNA-directed DNA polymerase activity
H1I72_00020	COG0187	DNA topoisomerase II activity
H1I72_00030	COG0586	Pfam SNARE associated Golgi protein
H1I72_00035	COG0488	(ABC) transporter
H1I72_00060	COG0596	Alpha beta hydrolase
H1I72_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H1I72_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H1I72_00110	COG0733	neurotransmitter:sodium symporter activity
H1I72_00150	COG2233	PERMEase
H1I72_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I72_00200	COG2814	Major facilitator Superfamily
H1I72_00205	COG0656	L-ascorbic acid biosynthetic process
H1I72_00210	COG0583	DNA-binding transcription factor activity
H1I72_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I72_00230	COG1064	alcohol dehydrogenase
H1I72_00235	COG2818	Glycosylase
H1I72_00250	COG1194	a g-specific adenine glycosylase
H1I72_00270	COG2983	Belongs to the UPF0260 family
H1I72_00275	COG2133	pyrroloquinoline quinone binding
H1I72_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H1I72_00285	COG2116	formate transmembrane transporter activity
H1I72_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I72_00310	COG1335	isochorismatase
H1I72_00315	COG0385	Bile acid
H1I72_00320	COG0534	Mate efflux family protein
H1I72_00325	COG1683	Conserved Protein
H1I72_00345	COG0625	glutathione transferase activity
H1I72_00355	COG1113	amino acid transport
H1I72_00365	COG0523	cobalamin synthesis protein
H1I72_00375	COG2188	Transcriptional regulator
H1I72_00405	COG0010	Belongs to the arginase family
H1I72_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I72_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1I72_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H1I72_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H1I72_00540	COG0534	Mate efflux family protein
H1I72_00545	COG0436	Aminotransferase
H1I72_00550	COG2733	membrane
H1I72_00565	COG2918	glutathione biosynthetic process
H1I72_00580	COG1388	LysM domain
H1I72_00580	COG0791	NLP P60 protein
H1I72_00595	COG3150	esterase
H1I72_00605	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H1I72_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I72_00630	COG2233	PERMEase
H1I72_00635	COG2351	hydroxyisourate hydrolase activity
H1I72_00670	COG3706	GGDEF domain
H1I72_00690	COG0708	Exodeoxyribonuclease III
H1I72_00710	COG0189	ligase activity
H1I72_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H1I72_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1I72_00755	COG4942	peptidase
H1I72_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I72_00775	COG2119	membrane
H1I72_00780	COG4774	siderophore transport
H1I72_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I72_00785	COG0426	domain, Protein
H1I72_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H1I72_00830	COG1902	pentaerythritol trinitrate reductase activity
H1I72_00835	COG1519	Transferase
H1I72_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I72_00845	COG0668	transmembrane transport
H1I72_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I72_00860	COG1335	isochorismatase
H1I72_00865	COG1522	sequence-specific DNA binding
H1I72_00870	COG3328	transposase activity
H1I72_00900	COG0784	Response regulator, receiver
H1I72_00900	COG2198	Histidine kinase
H1I72_00900	COG2205	protein histidine kinase activity
H1I72_00905	COG3162	membrane
H1I72_00910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I72_00920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I72_00940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H1I72_00945	COG1309	transcriptional regulator
H1I72_00965	COG0351	phosphomethylpyrimidine kinase
H1I72_00965	COG0352	thiamine-phosphate diphosphorylase activity
H1I72_00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I72_00975	COG2814	Major facilitator Superfamily
H1I72_00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I72_01000	COG1113	amino acid transport
H1I72_01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I72_01015	COG1012	belongs to the aldehyde dehydrogenase family
H1I72_01025	COG1335	isochorismatase
H1I72_01055	COG2814	Major facilitator Superfamily
H1I72_01060	COG0583	DNA-binding transcription factor activity
H1I72_01080	COG0667	Aldo Keto reductase
H1I72_01110	COG1733	regulation of RNA biosynthetic process
H1I72_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I72_01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H1I72_01195	COG2329	Antibiotic biosynthesis monooxygenase
H1I72_01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H1I72_01255	COG0427	acetyl-CoA hydrolase
H1I72_01280	COG0659	secondary active sulfate transmembrane transporter activity
H1I72_01285	COG4221	oxidoreductase activity
H1I72_01290	COG2873	o-acetylhomoserine
H1I72_01295	COG0488	(ABC) transporter
H1I72_01380	COG0833	amino acid
H1I72_01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H1I72_01445	COG2226	methyltransferase
H1I72_01495	COG0069	glutamate synthase activity
H1I72_01495	COG0067	glutamate synthase
H1I72_01495	COG0070	glutamate synthase
H1I72_01500	COG0493	'glutamate synthase
H1I72_01510	COG1704	LemA family
H1I72_01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H1I72_01535	COG3307	-O-antigen
H1I72_01560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I72_01575	COG0194	GDP metabolic process
H1I72_01625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H1I72_01645	COG5380	lipid catabolic process
H1I72_01650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H1I72_01675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1I72_01680	COG0277	FAD linked oxidase domain protein
H1I72_01690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H1I72_01695	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I72_01710	COG1289	transmembrane transporter activity
H1I72_01720	COG0628	permease
H1I72_01725	COG1192	Involved in chromosome partitioning
H1I72_01755	COG0833	amino acid
H1I72_01760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I72_01765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I72_01775	COG1012	belongs to the aldehyde dehydrogenase family
H1I72_01815	COG0583	DNA-binding transcription factor activity
H1I72_01860	COG0517	IMP dehydrogenase activity
H1I72_01865	COG1983	PspC domain protein
H1I72_01875	COG1960	acyl-CoA dehydrogenase activity
H1I72_01890	COG0408	coproporphyrinogen oxidase activity
H1I72_01910	COG0513	Belongs to the DEAD box helicase family
H1I72_01920	COG1127	ABC transporter
H1I72_01925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H1I72_01935	COG2854	intermembrane phospholipid transfer
H1I72_01945	COG0598	Magnesium transport protein CorA
H1I72_01955	COG0494	nUDIX hydrolase
H1I72_01960	COG1040	competence protein
H1I72_01965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H1I72_01985	COG1946	Acyl-CoA thioesterase
H1I72_01990	COG1301	dicarboxylic acid transport
H1I72_02005	COG1959	2 iron, 2 sulfur cluster binding
H1I72_02010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I72_02010	COG1017	nitric oxide dioxygenase activity
H1I72_02015	COG0433	COG0433 Predicted ATPase
H1I72_02020	COG0626	cystathionine gamma-synthase activity
H1I72_02175	COG1960	acyl-CoA dehydrogenase activity
H1I72_02180	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H1I72_02210	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H1I72_02220	COG0557	exoribonuclease II activity
H1I72_02265	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1I72_02270	COG2169	Transcriptional regulator
H1I72_02275	COG0697	spore germination
H1I72_02280	COG1295	ribonuclease BN
H1I72_02315	COG1702	phosphate starvation-inducible protein PhoH
H1I72_02325	COG0739	heme binding
H1I72_02325	COG0741	lytic transglycosylase activity
H1I72_02325	COG1196	nuclear chromosome segregation
H1I72_02355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H1I72_02360	COG1183	phosphatidylcholine synthase activity
H1I72_02405	COG1960	acyl-CoA dehydrogenase activity
H1I72_02410	COG1309	transcriptional regulator
H1I72_02425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I72_02430	COG1960	acyl-CoA dehydrogenase activity
H1I72_02450	COG2969	positive regulation of protein catabolic process
H1I72_02460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H1I72_02475	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1I72_02480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H1I72_02500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1I72_02510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I72_02515	COG1408	metallophosphoesterase
H1I72_02525	COG2199	diguanylate cyclase activity
H1I72_02585	COG1607	acyl-coa hydrolase
H1I72_02615	COG2350	Protein conserved in bacteria
H1I72_02625	COG0613	PHP domain protein
H1I72_02630	COG3781	membrane
H1I72_02640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H1I72_02645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H1I72_02655	COG1862	Preprotein translocase
H1I72_02685	COG2205	protein histidine kinase activity
H1I72_02690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H1I72_02710	COG0726	polysaccharide deacetylase
H1I72_02720	COG0438	transferase activity, transferring glycosyl groups
H1I72_02785	COG0625	glutathione transferase activity
H1I72_02790	COG0583	DNA-binding transcription factor activity
H1I72_02795	COG1960	acyl-CoA dehydrogenase activity
H1I72_02800	COG1960	acyl-CoA dehydrogenase activity
H1I72_02810	COG2205	protein histidine kinase activity
H1I72_02815	COG0745	RESPONSE REGULATOR receiver
H1I72_02820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H1I72_02840	COG2096	Adenosyltransferase
H1I72_02890	COG0285	dihydrofolate synthase activity
H1I72_02910	COG0450	alkyl hydroperoxide reductase
H1I72_02925	COG0477	Major facilitator Superfamily
H1I72_02930	COG1272	protein, Hemolysin III
H1I72_02960	COG0183	Belongs to the thiolase family
H1I72_02965	COG2207	Transcriptional regulator
H1I72_02985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I72_03015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H1I72_03015	COG2885	chlorophyll binding
H1I72_03025	COG1690	Belongs to the RtcB family
H1I72_03030	COG0833	amino acid
H1I72_03040	COG2233	PERMEase
H1I72_03045	COG1217	gtp-binding protein TYPA
H1I72_03070	COG2094	Belongs to the DNA glycosylase MPG family
H1I72_03075	COG4772	TonB-dependent receptor
H1I72_03090	COG1902	pentaerythritol trinitrate reductase activity
H1I72_03095	COG0679	Auxin Efflux Carrier
H1I72_03105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I72_03110	COG0354	folic acid binding
H1I72_03120	COG3189	MarR family transcriptional regulator
H1I72_03125	COG2824	Alkylphosphonate utilization operon protein PhnA
H1I72_03130	COG3422	double-strand break repair
H1I72_03170	COG0840	transmembrane signaling receptor activity
H1I72_03190	COG5510	response to toxic substance
H1I72_03200	COG2832	Protein of unknown function (DUF454)
H1I72_03205	COG1376	ErfK ybiS ycfS ynhG family protein
H1I72_03245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H1I72_03255	COG1289	transmembrane transporter activity
H1I72_03260	COG2814	Major facilitator Superfamily
H1I72_03285	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I72_03290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I72_03295	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H1I72_03325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I72_03335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I72_03340	COG1077	Cell shape determining protein MreB Mrl
H1I72_03345	COG1792	Involved in formation and maintenance of cell shape
H1I72_03360	COG1530	ribonuclease E activity
H1I72_03370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I72_03380	COG0560	Phosphoserine phosphatase
H1I72_03390	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I72_03415	COG2207	Transcriptional regulator
H1I72_03435	COG1113	amino acid transport
H1I72_03440	COG2828	Protein conserved in bacteria
H1I72_03445	COG0142	geranyltranstransferase activity
H1I72_03450	COG2315	Protein conserved in bacteria
H1I72_03465	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I72_03485	COG2194	sulfuric ester hydrolase activity
H1I72_03490	COG0745	RESPONSE REGULATOR receiver
H1I72_03495	COG0642	Histidine kinase
H1I72_03505	COG0004	ammonium transporteR
H1I72_03510	COG0583	DNA-binding transcription factor activity
H1I72_03530	COG0525	valine-tRNA ligase activity
H1I72_03540	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_03550	COG0393	Putative heavy-metal-binding
H1I72_03555	COG0393	Putative heavy-metal-binding
H1I72_03560	COG1538	Outer membrane efflux protein
H1I72_03570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I72_03575	COG0671	phosphoesterase, PA-phosphatase related
H1I72_03605	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H1I72_03620	COG1648	precorrin-2 dehydrogenase activity
H1I72_03620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H1I72_03625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H1I72_03630	COG1733	regulation of RNA biosynthetic process
H1I72_03640	COG0531	amino acid
H1I72_03655	COG0321	lipoyl(octanoyl) transferase activity
H1I72_03660	COG2921	Belongs to the UPF0250 family
H1I72_03700	COG2009	succinate dehydrogenase
H1I72_03705	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H1I72_03710	COG1053	succinate dehydrogenase
H1I72_03715	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H1I72_03740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I72_03760	COG2354	Protein conserved in bacteria
H1I72_03765	COG2321	neutral zinc metallopeptidase
H1I72_03800	COG2843	Capsule synthesis protein
H1I72_03815	COG0589	response to stress
H1I72_03835	COG0505	Belongs to the CarA family
H1I72_03860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I72_03865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H1I72_03915	COG0477	Major facilitator Superfamily
H1I72_03920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H1I72_03935	COG1597	lipid kinase activity
H1I72_03940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I72_03970	COG0584	glycerophosphoryl diester phosphodiesterase
H1I72_03990	COG0741	lytic transglycosylase activity
H1I72_04010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1I72_04025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I72_04050	COG0778	Nitroreductase
H1I72_04065	COG1929	Belongs to the glycerate kinase type-1 family
H1I72_04070	COG0243	molybdopterin cofactor binding
H1I72_04075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H1I72_04080	COG3339	Conserved Protein
H1I72_04090	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H1I72_04105	COG1113	amino acid transport
H1I72_04115	COG0019	diaminopimelate decarboxylase activity
H1I72_04125	COG1280	lysine exporter protein (LysE YggA)
H1I72_04130	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H1I72_04160	COG0463	Glycosyl transferase, family 2
H1I72_04180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I72_04215	COG4591	ABC-type transport system involved in lipoprotein release permease component
H1I72_04220	COG1136	(ABC) transporter
H1I72_04225	COG0658	competence protein
H1I72_04225	COG2333	competence protein COMEC
H1I72_04235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H1I72_04235	COG0616	signal peptide processing
H1I72_04240	COG0596	Alpha beta hydrolase
H1I72_04245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H1I72_04255	COG0628	permease
H1I72_04290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I72_04310	COG0823	Involved in the tonB-independent uptake of proteins
H1I72_04330	COG0824	Thioesterase
H1I72_04335	COG1473	amidohydrolase
H1I72_04355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1I72_04355	COG0047	phosphoribosylformylglycinamidine synthase activity
H1I72_04360	COG2814	Major facilitator Superfamily
H1I72_04370	COG1024	Enoyl-CoA hydratase
H1I72_04375	COG1056	cytidyltransferase-related domain
H1I72_04375	COG1051	belongs to the nudix hydrolase family
H1I72_04385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H1I72_04400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H1I72_04415	COG4625	pathogenesis
H1I72_04420	COG0583	DNA-binding transcription factor activity
H1I72_04425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1I72_04430	COG4208	sulfate ABC transporter
H1I72_04435	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H1I72_04445	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H1I72_04450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1I72_04455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H1I72_04475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I72_04490	COG0681	Belongs to the peptidase S26 family
H1I72_04505	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H1I72_04515	COG1381	Involved in DNA repair and RecF pathway recombination
H1I72_04520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H1I72_04560	COG0436	Aminotransferase
H1I72_04580	COG0556	nucleotide-excision repair
H1I72_04635	COG2070	2-Nitropropane dioxygenase
H1I72_04665	COG1215	transferase activity, transferring glycosyl groups
H1I72_04680	COG0415	Belongs to the DNA photolyase family
H1I72_04690	COG1252	NADH dehydrogenase
H1I72_04695	COG1686	Belongs to the peptidase S11 family
H1I72_04710	COG1187	pseudouridine synthase activity
H1I72_04735	COG0477	Major facilitator Superfamily
H1I72_04740	COG0583	DNA-binding transcription factor activity
H1I72_04745	COG1823	symporter activity
H1I72_04755	COG0612	Peptidase, M16
H1I72_04780	COG0352	thiamine-phosphate diphosphorylase activity
H1I72_04815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I72_04830	COG1309	transcriptional regulator
H1I72_04840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I72_04845	COG0076	glutamate decarboxylase activity
H1I72_04855	COG1522	sequence-specific DNA binding
H1I72_04860	COG3961	Belongs to the TPP enzyme family
H1I72_04865	COG1113	amino acid transport
H1I72_04870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I72_04875	COG0573	inorganic phosphate transmembrane transporter activity
H1I72_04885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1I72_04890	COG0616	signal peptide processing
H1I72_04925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H1I72_04930	COG1686	Belongs to the peptidase S11 family
H1I72_04955	COG0583	DNA-binding transcription factor activity
H1I72_04960	COG1067	ATP-dependent peptidase activity
H1I72_05005	COG1966	Carbon starvation protein
H1I72_05010	COG2879	small protein
H1I72_05040	COG2508	Transcriptional regulator
H1I72_05040	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H1I72_05060	COG1113	amino acid transport
H1I72_05065	COG0583	DNA-binding transcription factor activity
H1I72_05070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I72_05085	COG1012	belongs to the aldehyde dehydrogenase family
H1I72_05090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I72_05130	COG2814	Major facilitator Superfamily
H1I72_05135	COG4948	Mandelate Racemase Muconate Lactonizing
H1I72_05145	COG1309	transcriptional regulator
H1I72_05165	COG1741	Belongs to the pirin family
H1I72_05175	COG2964	Protein conserved in bacteria
H1I72_05190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I72_05195	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I72_05200	COG4605	iron ion homeostasis
H1I72_05205	COG4604	ABC transporter, ATP-binding protein
H1I72_05210	COG4607	ABC-type enterochelin transport system periplasmic component
H1I72_05225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I72_05230	COG1021	2,3-dihydroxybenzoate-AMP ligase
H1I72_05235	COG3433	isochorismatase activity
H1I72_05235	COG1535	isochorismatase
H1I72_05250	COG1132	(ABC) transporter
H1I72_05255	COG1132	(ABC) transporter
H1I72_05260	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H1I72_05270	COG1169	isochorismate synthase
H1I72_05285	COG3739	integral membrane protein
H1I72_05310	COG0302	gtp cyclohydrolase
H1I72_05320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1I72_05350	COG0308	aminopeptidase N
H1I72_05355	COG0512	Glutamine amidotransferase of anthranilate synthase
H1I72_05370	COG0174	glutamine synthetase
H1I72_05380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H1I72_05415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H1I72_05420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H1I72_05425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I72_05445	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I72_05450	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H1I72_05455	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H1I72_05470	COG1960	acyl-CoA dehydrogenase activity
H1I72_05475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I72_05480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I72_05490	COG2223	nitrite transmembrane transporter activity
H1I72_05500	COG0024	Methionine aminopeptidase
H1I72_05505	COG0052	Belongs to the universal ribosomal protein uS2 family
H1I72_05520	COG2207	Transcriptional regulator
H1I72_05545	COG2951	lytic endotransglycosylase activity
H1I72_05550	COG0772	Belongs to the SEDS family
H1I72_05565	COG0842	Transport permease protein
H1I72_05570	COG1131	(ABC) transporter
H1I72_05615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I72_05630	COG4215	(ABC) transporter
H1I72_05635	COG4160	amino acid transport
H1I72_05640	COG4598	ABC transporter
H1I72_05650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I72_05655	COG0826	peptidase U32
H1I72_05660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I72_05675	COG1720	tRNA m6t6A37 methyltransferase activity
H1I72_05685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H1I72_05700	COG0642	Histidine kinase
H1I72_05710	COG0494	nUDIX hydrolase
H1I72_05720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1I72_05725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H1I72_05730	COG3139	Protein of unknown function (DUF1315)
H1I72_05735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1I72_05740	COG1301	dicarboxylic acid transport
H1I72_05745	COG1960	acyl-CoA dehydrogenase activity
H1I72_05770	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1I72_05775	COG1234	tRNA 3'-trailer cleavage
H1I72_05805	COG2363	Small membrane protein
H1I72_05835	COG0778	Nitroreductase
H1I72_06175	COG1286	toxin biosynthetic process
H1I72_06200	COG4783	chaperone-mediated protein folding
H1I72_06205	COG1610	YqeY-like protein
H1I72_06305	COG3111	PFAM Bacterial OB fold (BOF) protein
H1I72_06330	COG3243	poly(R)-hydroxyalkanoic acid synthase
H1I72_06335	COG0786	glutamate:sodium symporter activity
H1I72_06345	COG2186	Transcriptional regulator
H1I72_06395	COG0477	Major facilitator Superfamily
H1I72_06420	COG2985	domain, Protein
H1I72_06430	COG2995	paraquat-inducible protein a
H1I72_06445	COG1794	racemase activity, acting on amino acids and derivatives
H1I72_06530	COG0482	sulfurtransferase activity
H1I72_06545	COG0488	(ABC) transporter
H1I72_06550	COG3173	Aminoglycoside phosphotransferase
H1I72_06560	COG2433	Pfam Transposase IS66
H1I72_06580	COG1309	transcriptional regulator
H1I72_06585	COG1741	Belongs to the pirin family
H1I72_06600	COG2072	flavoprotein involved in K transport
H1I72_06610	COG2252	PERMEase
H1I72_06615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H1I72_06620	COG3038	cytochrome b561
H1I72_06640	COG0527	aspartate kinase activity
H1I72_06650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H1I72_06660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H1I72_06675	COG0667	Aldo Keto reductase
H1I72_06690	COG1765	OsmC-like protein
H1I72_06705	COG0542	response to heat
H1I72_06740	COG2885	chlorophyll binding
H1I72_06750	COG0625	glutathione transferase activity
H1I72_06755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H1I72_06785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1I72_06795	COG0450	alkyl hydroperoxide reductase
H1I72_06800	COG1643	Atp-dependent helicase
H1I72_06815	COG2814	Major facilitator Superfamily
H1I72_06820	COG3135	benzoate transporter
H1I72_06825	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_06830	COG0633	Ferredoxin
H1I72_06830	COG0543	2 iron, 2 sulfur cluster binding
H1I72_06835	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I72_06840	COG4638	Rieske (2fe-2S)
H1I72_06845	COG0583	DNA-binding transcription factor activity
H1I72_06895	COG1570	exodeoxyribonuclease VII activity
H1I72_06925	COG1280	lysine exporter protein (LysE YggA)
H1I72_06930	COG1278	Cold shock
H1I72_06965	COG2814	Major facilitator Superfamily
H1I72_07000	COG0517	IMP dehydrogenase activity
H1I72_07000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H1I72_07005	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H1I72_07015	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H1I72_07020	COG1137	ATPase activity
H1I72_07025	COG1538	Outer membrane efflux protein
H1I72_07055	COG4122	O-methyltransferase activity
H1I72_07065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1I72_07080	COG1522	sequence-specific DNA binding
H1I72_07085	COG5006	permease, DMT superfamily
H1I72_07095	COG1560	Kdo2-lipid A biosynthetic process
H1I72_07105	COG2814	Major facilitator Superfamily
H1I72_07125	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I72_07175	COG0583	DNA-binding transcription factor activity
H1I72_07180	COG1914	H( )-stimulated, divalent metal cation uptake system
H1I72_07205	COG0038	chloride channel
H1I72_07225	COG1309	transcriptional regulator
H1I72_07235	COG1063	alcohol dehydrogenase
H1I72_07250	COG0439	Biotin carboxylase
H1I72_07255	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I72_07275	COG0864	Transcriptional regulator
H1I72_07285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I72_07290	COG1116	anion transmembrane transporter activity
H1I72_07405	COG0590	tRNA wobble adenosine to inosine editing
H1I72_07410	COG2807	transmembrane transport
H1I72_07425	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H1I72_07440	COG0789	Transcriptional regulator
H1I72_07450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I72_07470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I72_07480	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I72_07495	COG1012	belongs to the aldehyde dehydrogenase family
H1I72_07500	COG0531	amino acid
H1I72_07505	COG1760	l-serine dehydratase
H1I72_07510	COG1012	belongs to the aldehyde dehydrogenase family
H1I72_07510	COG2030	dehydratase
H1I72_07515	COG3396	Phenylacetate-CoA oxygenase
H1I72_07520	COG3460	Phenylacetate-CoA oxygenase
H1I72_07525	COG3396	Phenylacetate-CoA oxygenase
H1I72_07530	COG2151	metal-sulfur cluster biosynthetic enzyme
H1I72_07535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I72_07540	COG1024	Enoyl-CoA hydratase
H1I72_07545	COG1024	Enoyl-CoA hydratase
H1I72_07550	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I72_07555	COG0183	Belongs to the thiolase family
H1I72_07560	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H1I72_07565	COG3327	negative regulation of DNA-templated transcription, initiation
H1I72_07575	COG2050	protein possibly involved in aromatic compounds catabolism
H1I72_07610	COG0753	catalase activity
H1I72_07615	COG3038	cytochrome b561
H1I72_07635	COG2267	carboxylic ester hydrolase activity
H1I72_07640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I72_07645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I72_07650	COG1012	belongs to the aldehyde dehydrogenase family
H1I72_07660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I72_07670	COG1012	belongs to the aldehyde dehydrogenase family
H1I72_07675	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I72_07680	COG0583	DNA-binding transcription factor activity
H1I72_07690	COG1414	Transcriptional regulator
H1I72_07695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I72_07705	COG1840	ABC-type Fe3 transport system, periplasmic component
H1I72_07710	COG3842	ATPase activity
H1I72_07725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H1I72_07730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I72_07735	COG2814	Major facilitator Superfamily
H1I72_07740	COG1960	acyl-CoA dehydrogenase activity
H1I72_07755	COG1024	Enoyl-CoA hydratase
H1I72_07765	COG2814	Major facilitator Superfamily
H1I72_07775	COG0183	Belongs to the thiolase family
H1I72_07780	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I72_07785	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_07790	COG1024	Enoyl-CoA hydratase
H1I72_07795	COG1960	acyl-CoA dehydrogenase activity
H1I72_07800	COG2814	Major facilitator Superfamily
H1I72_07805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I72_07810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I72_07820	COG2814	Major facilitator Superfamily
H1I72_07830	COG1960	acyl-CoA dehydrogenase activity
H1I72_07845	COG0583	DNA-binding transcription factor activity
H1I72_07855	COG4770	biotin carboxylase activity
H1I72_07860	COG1024	Enoyl-CoA hydratase
H1I72_07865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I72_07870	COG1960	acyl-CoA dehydrogenase activity
H1I72_07875	COG1309	transcriptional regulator
H1I72_07905	COG0583	DNA-binding transcription factor activity
H1I72_07955	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_07975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1I72_07995	COG0784	Response regulator, receiver
H1I72_07995	COG2205	protein histidine kinase activity
H1I72_08015	COG0765	amino acid transport
H1I72_08020	COG0765	amino acid transport
H1I72_08025	COG1126	abc transporter atp-binding protein
H1I72_08030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I72_08035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I72_08050	COG1280	lysine exporter protein (LysE YggA)
H1I72_08060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H1I72_08065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I72_08070	COG1045	serine acetyltransferase
H1I72_08085	COG0583	DNA-binding transcription factor activity
H1I72_08090	COG0625	glutathione transferase activity
H1I72_08095	COG0625	glutathione transferase activity
H1I72_08100	COG0583	DNA-binding transcription factor activity
H1I72_08110	COG1346	cytolysis
H1I72_08130	COG2814	Major facilitator Superfamily
H1I72_08145	COG3052	prosthetic group binding
H1I72_08165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1I72_08185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I72_08195	COG1294	oxidase, subunit
H1I72_08200	COG1271	oxidase subunit
H1I72_08220	COG0477	Major facilitator Superfamily
H1I72_08230	COG4521	taurine ABC transporter
H1I72_08235	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H1I72_08240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I72_08245	COG2175	clavaminate synthase activity
H1I72_08255	COG1953	Uracil, thiamine, allantoin
H1I72_08265	COG0583	DNA-binding transcription factor activity
H1I72_08275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H1I72_08290	COG0640	Transcriptional regulator
H1I72_08295	COG0798	PFAM Bile acid sodium symporter
H1I72_08300	COG0583	DNA-binding transcription factor activity
H1I72_08360	COG0436	Aminotransferase
H1I72_08370	COG0386	Belongs to the glutathione peroxidase family
H1I72_08410	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I72_08435	COG0012	GTP binding
H1I72_08440	COG2011	ABC-type metal ion transport system permease component
H1I72_08445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I72_08455	COG1464	Belongs to the NlpA lipoprotein family
H1I72_08485	COG0765	amino acid transport
H1I72_08490	COG0765	amino acid transport
H1I72_08495	COG1126	abc transporter atp-binding protein
H1I72_08510	COG1522	sequence-specific DNA binding
H1I72_08525	COG1309	transcriptional regulator
H1I72_08545	COG0583	DNA-binding transcription factor activity
H1I72_08555	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I72_08565	COG0697	spore germination
H1I72_08590	COG3121	Chaperone
H1I72_08595	COG3539	Fimbrial protein
H1I72_08620	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H1I72_08620	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H1I72_08665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H1I72_08675	COG2353	YceI-like domain
H1I72_08685	COG3698	Phosphodiester glycosidase
H1I72_08700	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H1I72_08705	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I72_08705	COG0506	proline dehydrogenase activity
H1I72_08705	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I72_08715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I72_08720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H1I72_08740	COG1132	(ABC) transporter
H1I72_08745	COG3122	Protein conserved in bacteria
H1I72_08750	COG3619	membrane
H1I72_08760	COG0640	Transcriptional regulator
H1I72_08770	COG2850	peptidyl-arginine hydroxylation
H1I72_08775	COG0424	maF-like protein
H1I72_08795	COG0191	fructose-bisphosphate aldolase activity
H1I72_08800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I72_08815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1I72_08825	COG1192	Involved in chromosome partitioning
H1I72_08830	COG1475	DNA binding
H1I72_08835	COG0811	peptide transport
H1I72_08845	COG1132	(ABC) transporter
H1I72_08850	COG1663	tetraacyldisaccharide 4'-kinase activity
H1I72_08870	COG0084	hydrolase, TatD family'
H1I72_08935	COG0776	regulation of translation
H1I72_08970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H1I72_09030	COG0339	signal peptide processing
H1I72_09040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1I72_09075	COG0702	epimerase
H1I72_09080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I72_09105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H1I72_09135	COG0316	Belongs to the HesB IscA family
H1I72_09140	COG0822	iron-sulfur transferase activity
H1I72_09165	COG0776	regulation of translation
H1I72_09170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I72_09175	COG2207	Transcriptional regulator
H1I72_09180	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I72_09185	COG1960	acyl-CoA dehydrogenase activity
H1I72_09190	COG1960	acyl-CoA dehydrogenase activity
H1I72_09205	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1I72_09225	COG4264	IucA IucC family
H1I72_09230	COG4264	IucA IucC family
H1I72_09270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I72_09285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H1I72_09305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H1I72_09330	COG4773	Receptor
H1I72_09335	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I72_09350	COG1131	(ABC) transporter
H1I72_09355	COG0842	Transport permease protein
H1I72_09360	COG0842	Transport permease protein
H1I72_09415	COG2226	methyltransferase
H1I72_09440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H1I72_09475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I72_09485	COG0133	tryptophan synthase activity
H1I72_09500	COG3706	GGDEF domain
H1I72_09515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I72_09520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H1I72_09525	COG0022	dehydrogenase e1 component
H1I72_09530	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I72_09535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I72_09545	COG1063	alcohol dehydrogenase
H1I72_09550	COG3781	membrane
H1I72_09560	COG3453	Protein conserved in bacteria
H1I72_09560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I72_09570	COG0730	response to heat
H1I72_09585	COG3708	Transcriptional regulator
H1I72_09585	COG2207	Transcriptional regulator
H1I72_09590	COG1733	regulation of RNA biosynthetic process
H1I72_09595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H1I72_09605	COG2188	Transcriptional regulator
H1I72_09620	COG4521	taurine ABC transporter
H1I72_09625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I72_09645	COG0477	Major facilitator Superfamily
H1I72_09655	COG1027	Aspartate ammonia-lyase
H1I72_09670	COG0583	DNA-binding transcription factor activity
H1I72_09675	COG0583	DNA-binding transcription factor activity
H1I72_09680	COG0183	Belongs to the thiolase family
H1I72_09685	COG2031	fatty acid transporter
H1I72_09690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I72_09700	COG0583	DNA-binding transcription factor activity
H1I72_09710	COG2610	gluconate transmembrane transporter activity
H1I72_09715	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_09725	COG2207	Transcriptional regulator
H1I72_09740	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_09765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I72_09765	COG0543	2 iron, 2 sulfur cluster binding
H1I72_09770	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I72_09775	COG4638	Rieske (2fe-2S)
H1I72_09785	COG0725	ABC transporter, periplasmic molybdate-binding protein
H1I72_09790	COG4149	molybdate abc transporter
H1I72_09795	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H1I72_09800	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_09805	COG3433	isochorismatase activity
H1I72_09805	COG1535	isochorismatase
H1I72_09870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I72_09885	COG0753	catalase activity
H1I72_09895	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H1I72_09925	COG3539	Fimbrial protein
H1I72_09945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I72_09965	COG2072	flavoprotein involved in K transport
H1I72_09975	COG1538	Outer membrane efflux protein
H1I72_09980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I72_09985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I72_09990	COG0745	RESPONSE REGULATOR receiver
H1I72_09995	COG2205	protein histidine kinase activity
H1I72_10010	COG2207	Transcriptional regulator
H1I72_10025	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_10075	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H1I72_10190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I72_10210	COG1120	ATPase activity
H1I72_10225	COG1064	alcohol dehydrogenase
H1I72_10240	COG2207	Transcriptional regulator
H1I72_10245	COG2084	Dehydrogenase
H1I72_10255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1I72_10260	COG0583	DNA-binding transcription factor activity
H1I72_10270	COG0129	dihydroxy-acid dehydratase activity
H1I72_10275	COG1012	belongs to the aldehyde dehydrogenase family
H1I72_10290	COG1566	PFAM secretion protein HlyD family protein
H1I72_10310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I72_10340	COG0583	DNA-binding transcription factor activity
H1I72_10355	COG2188	Transcriptional regulator
H1I72_10385	COG3210	domain, Protein
H1I72_10390	COG2831	hemolysin activation secretion protein
H1I72_10405	COG1473	amidohydrolase
H1I72_10415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I72_10415	COG0475	glutathione-regulated potassium exporter activity
H1I72_10425	COG0583	DNA-binding transcription factor activity
H1I72_10430	COG1335	isochorismatase
H1I72_10440	COG1309	transcriptional regulator
H1I72_10470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H1I72_10485	COG1846	Transcriptional regulator
H1I72_10505	COG0753	catalase activity
H1I72_10520	COG1012	belongs to the aldehyde dehydrogenase family
H1I72_10535	COG3162	membrane
H1I72_10545	COG3829	transcription factor binding
H1I72_10550	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_10555	COG1960	acyl-CoA dehydrogenase activity
H1I72_10575	COG1012	belongs to the aldehyde dehydrogenase family
H1I72_10595	COG2186	Transcriptional regulator
H1I72_10605	COG0583	DNA-binding transcription factor activity
H1I72_10610	COG4948	Mandelate Racemase Muconate Lactonizing
H1I72_10615	COG4829	muconolactone delta-isomerase
H1I72_10630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I72_10635	COG0183	Belongs to the thiolase family
H1I72_10640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I72_10650	COG1012	belongs to the aldehyde dehydrogenase family
H1I72_10660	COG3733	amine oxidase
H1I72_10670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I72_10680	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_10690	COG4638	Rieske (2fe-2S)
H1I72_10710	COG0154	amidase activity
H1I72_10720	COG2814	Major facilitator Superfamily
H1I72_10745	COG1960	acyl-CoA dehydrogenase activity
H1I72_10750	COG0583	DNA-binding transcription factor activity
H1I72_10755	COG1414	Transcriptional regulator
H1I72_10770	COG2391	methyltransferase activity
H1I72_10780	COG4993	Dehydrogenase
H1I72_10785	COG3659	wide pore channel activity
H1I72_10790	COG3420	alginic acid biosynthetic process
H1I72_10795	COG0710	3-dehydroquinate dehydratase activity
H1I72_10800	COG3485	protocatechuate 3,4-dioxygenase
H1I72_10805	COG3485	protocatechuate 3,4-dioxygenase
H1I72_10810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I72_10815	COG2271	Major facilitator Superfamily
H1I72_10820	COG0596	Alpha beta hydrolase
H1I72_10825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H1I72_10830	COG0183	Belongs to the thiolase family
H1I72_10835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I72_10840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I72_10850	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H1I72_10855	COG2323	membrane
H1I72_10900	COG1902	pentaerythritol trinitrate reductase activity
H1I72_10900	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I72_10925	COG0542	response to heat
H1I72_10930	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1I72_10960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I72_10965	COG0569	domain protein
H1I72_10970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H1I72_10985	COG4774	siderophore transport
H1I72_10990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1I72_11000	COG1585	Membrane protein implicated in regulation of membrane protease activity
H1I72_11015	COG1294	oxidase, subunit
H1I72_11020	COG4890	Cyd operon protein YbgT
H1I72_11045	COG0552	protein localization to endoplasmic reticulum
H1I72_11075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I72_11080	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H1I72_11090	COG0583	DNA-binding transcription factor activity
H1I72_11095	COG0024	Methionine aminopeptidase
H1I72_11125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I72_11125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1I72_11130	COG1105	Belongs to the carbohydrate kinase PfkB family
H1I72_11135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I72_11135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I72_11135	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H1I72_11155	COG3300	MHYT domain
H1I72_11155	COG5001	Diguanylate cyclase
H1I72_11170	COG2135	peptidase activity
H1I72_11175	COG0659	secondary active sulfate transmembrane transporter activity
H1I72_11190	COG1113	amino acid transport
H1I72_11200	COG1522	sequence-specific DNA binding
H1I72_11225	COG1011	Hydrolase
H1I72_11230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H1I72_11240	COG2137	regulation of response to DNA damage stimulus
H1I72_11255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I72_11290	COG0575	Belongs to the CDS family
H1I72_11295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H1I72_11315	COG3852	Histidine kinase
H1I72_11320	COG2204	response regulator
H1I72_11385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I72_11390	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H1I72_11410	COG0697	spore germination
H1I72_11415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I72_11425	COG0303	'Molybdopterin
H1I72_11430	COG0315	cyclic pyranopterin monophosphate synthase activity
H1I72_11430	COG0521	Mo-molybdopterin cofactor biosynthetic process
H1I72_11445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H1I72_11450	COG0243	molybdopterin cofactor binding
H1I72_11460	COG0243	molybdopterin cofactor binding
H1I72_11465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I72_11470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I72_11470	COG2146	nitrite reductase [NAD(P)H] activity
H1I72_11480	COG0745	RESPONSE REGULATOR receiver
H1I72_11485	COG1116	anion transmembrane transporter activity
H1I72_11485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I72_11505	COG0511	ligase activity, forming carbon-carbon bonds
H1I72_11520	COG2814	Major facilitator Superfamily
H1I72_11735	COG5410	chromosome segregation
H1I72_11910	COG0069	glutamate synthase activity
H1I72_11930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H1I72_11940	COG1454	alcohol dehydrogenase
H1I72_11945	COG0824	Thioesterase
H1I72_11955	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H1I72_11970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I72_11975	COG2030	dehydratase
H1I72_11985	COG0183	Belongs to the thiolase family
H1I72_11995	COG0583	DNA-binding transcription factor activity
H1I72_12000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H1I72_12010	COG1522	sequence-specific DNA binding
H1I72_12015	COG3135	benzoate transporter
H1I72_12025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H1I72_12050	COG0589	response to stress
H1I72_12055	COG0488	(ABC) transporter
H1I72_12075	COG4773	Receptor
H1I72_12110	COG0668	transmembrane transport
H1I72_12120	COG1309	transcriptional regulator
H1I72_12135	COG1605	Chorismate mutase
H1I72_12145	COG4221	oxidoreductase activity
H1I72_12155	COG0308	aminopeptidase N
H1I72_12175	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H1I72_12185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I72_12190	COG1454	alcohol dehydrogenase
H1I72_12210	COG0531	amino acid
H1I72_12215	COG4303	Ethanolamine ammonia lyase large subunit
H1I72_12220	COG4302	ethanolamine ammonia-lyase activity
H1I72_12225	COG0519	Catalyzes the synthesis of GMP from XMP
H1I72_12225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I72_12230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I72_12240	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I72_12255	COG0697	spore germination
H1I72_12260	COG1923	regulation of RNA biosynthetic process
H1I72_12270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H1I72_12275	COG0802	atpase or kinase
H1I72_12295	COG1187	pseudouridine synthase activity
H1I72_12310	COG0583	DNA-binding transcription factor activity
H1I72_12325	COG2814	Major facilitator Superfamily
H1I72_12330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I72_12375	COG0174	glutamine synthetase
H1I72_12380	COG0745	RESPONSE REGULATOR receiver
H1I72_12385	COG2205	protein histidine kinase activity
H1I72_12395	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H1I72_12400	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H1I72_12425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I72_12430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I72_12435	COG1960	acyl-CoA dehydrogenase activity
H1I72_12450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I72_12455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I72_12490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I72_12500	COG3658	cytochrome
H1I72_12510	COG0726	polysaccharide deacetylase
H1I72_12510	COG1649	PFAM Uncharacterised BCR, COG1649
H1I72_12535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H1I72_12540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1I72_12550	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H1I72_12575	COG0305	Participates in initiation and elongation during chromosome replication
H1I72_12580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1I72_12590	COG1305	Transglutaminase-like
H1I72_12600	COG2308	Evidence 4 Homologs of previously reported genes of
H1I72_12630	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H1I72_12635	COG0138	bifunctional purine biosynthesis protein purh
H1I72_12640	COG0151	Belongs to the GarS family
H1I72_12645	COG1464	Belongs to the NlpA lipoprotein family
H1I72_12650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I72_12655	COG2011	ABC-type metal ion transport system permease component
H1I72_12660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I72_12670	COG1301	dicarboxylic acid transport
H1I72_12695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H1I72_12825	COG4269	membrane
H1I72_12840	COG1902	pentaerythritol trinitrate reductase activity
H1I72_12840	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I72_12850	COG2203	Gaf domain
H1I72_12850	COG3706	GGDEF domain
H1I72_12850	COG4251	negative regulation of phosphorylation
H1I72_12850	COG5001	Diguanylate cyclase
H1I72_12860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I72_12880	COG4172	Belongs to the ABC transporter superfamily
H1I72_12885	COG4239	(ABC) transporter, permease
H1I72_12890	COG4174	ABC transporter (Permease)
H1I72_12900	COG1388	LysM domain
H1I72_12900	COG0741	lytic transglycosylase activity
H1I72_12900	COG0741	lytic transglycosylase activity
H1I72_12900	COG1388	LysM domain
H1I72_12905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I72_12945	COG0583	DNA-binding transcription factor activity
H1I72_12950	COG1279	arginine transmembrane transporter activity
H1I72_12970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I72_12975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I72_12980	COG0006	proline dipeptidase activity
H1I72_13065	COG1196	nuclear chromosome segregation
H1I72_13065	COG0739	heme binding
H1I72_13065	COG0741	lytic transglycosylase activity
H1I72_13125	COG4695	Portal protein
H1I72_13220	COG0305	Participates in initiation and elongation during chromosome replication
H1I72_13235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1I72_13285	COG2194	sulfuric ester hydrolase activity
H1I72_13330	COG0739	heme binding
H1I72_13655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H1I72_13680	COG3384	dioxygenase
H1I72_13690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I72_13695	COG2878	Part of a membrane complex involved in electron transport
H1I72_13700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H1I72_13725	COG0768	penicillin binding
H1I72_13730	COG0742	ribosomal rna small subunit methyltransferase
H1I72_13745	COG0830	nickel cation binding
H1I72_13755	COG0804	urea catabolic process
H1I72_13795	COG1253	flavin adenine dinucleotide binding
H1I72_13800	COG2851	Citrate transporter
H1I72_13850	COG1773	rubredoxin
H1I72_13855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I72_13865	COG0583	DNA-binding transcription factor activity
H1I72_13890	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H1I72_13895	COG4181	ATPase activity
H1I72_13940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H1I72_13960	COG0306	phosphate transporter
H1I72_13970	COG3958	Transketolase
H1I72_13975	COG3959	Transketolase, thiamine diphosphate binding domain
H1I72_13980	COG2271	Major facilitator Superfamily
H1I72_13985	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_13990	COG0583	DNA-binding transcription factor activity
H1I72_14005	COG2223	nitrite transmembrane transporter activity
H1I72_14010	COG2207	Transcriptional regulator
H1I72_14015	COG2066	Belongs to the glutaminase family
H1I72_14020	COG0242	peptide deformylase activity
H1I72_14025	COG0477	Major facilitator Superfamily
H1I72_14035	COG0028	Belongs to the TPP enzyme family
H1I72_14050	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_14065	COG2271	Major facilitator Superfamily
H1I72_14070	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I72_14080	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_14100	COG1414	Transcriptional regulator
H1I72_14115	COG1024	Enoyl-CoA hydratase
H1I72_14125	COG1215	transferase activity, transferring glycosyl groups
H1I72_14130	COG0726	polysaccharide deacetylase
H1I72_14130	COG1649	PFAM Uncharacterised BCR, COG1649
H1I72_14140	COG4681	YaeQ
H1I72_14160	COG1607	acyl-coa hydrolase
H1I72_14205	COG2040	homocysteine
H1I72_14210	COG0531	amino acid
H1I72_14265	COG1595	DNA-templated transcription, initiation
H1I72_14275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I72_14280	COG0477	Major facilitator Superfamily
H1I72_14300	COG0084	hydrolase, TatD family'
H1I72_14335	COG0629	single-stranded DNA binding
H1I72_14385	COG0582	viral genome integration into host DNA
H1I72_14410	COG1061	Type III restriction enzyme res subunit
H1I72_14420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I72_14425	COG1192	Involved in chromosome partitioning
H1I72_14435	COG1061	Type III restriction enzyme res subunit
H1I72_14520	COG0592	DNA-directed DNA polymerase activity
H1I72_14560	COG2026	Addiction module toxin, RelE StbE family
H1I72_14710	COG3755	Protein conserved in bacteria
H1I72_14755	COG1484	DNA-dependent DNA replication
H1I72_14845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I72_14915	COG0405	Gamma-glutamyltransferase
H1I72_14920	COG2814	Major facilitator Superfamily
H1I72_14930	COG2050	protein possibly involved in aromatic compounds catabolism
H1I72_14945	COG1090	epimerase
H1I72_14965	COG0420	3'-5' exonuclease activity
H1I72_14990	COG0735	belongs to the Fur family
H1I72_14995	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1I72_15015	COG0121	glutamine amidotransferase
H1I72_15030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I72_15040	COG0210	DNA helicase
H1I72_15045	COG2885	chlorophyll binding
H1I72_15050	COG0204	Acyl-transferase
H1I72_15065	COG2894	cell division
H1I72_15085	COG1280	lysine exporter protein (LysE YggA)
H1I72_15090	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H1I72_15090	COG1674	ftsk spoiiie
H1I72_15095	COG0492	ferredoxin-NADP+ reductase activity
H1I72_15100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H1I72_15110	COG0456	acetyltransferase
H1I72_15155	COG1981	membrane
H1I72_15170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I72_15170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H1I72_15190	COG1012	belongs to the aldehyde dehydrogenase family
H1I72_15200	COG0657	acetylesterase activity
H1I72_15210	COG0473	3-isopropylmalate dehydrogenase activity
H1I72_15215	COG0583	DNA-binding transcription factor activity
H1I72_15235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I72_15260	COG0564	pseudouridine synthase activity
H1I72_15270	COG0358	DNA primase activity
H1I72_15285	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H1I72_15315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I72_15345	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1I72_15355	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I72_15355	COG0351	phosphomethylpyrimidine kinase
H1I72_15355	COG0352	thiamine-phosphate diphosphorylase activity
H1I72_15360	COG1652	LysM domain
H1I72_15385	COG1399	metal-binding, possibly nucleic acid-binding protein
H1I72_15390	COG3101	peptidyl-lysine hydroxylation
H1I72_15395	COG0009	L-threonylcarbamoyladenylate synthase
H1I72_15400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H1I72_15405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H1I72_15420	COG4106	trans-aconitate 2-methyltransferase activity
H1I72_15435	COG2226	methyltransferase
H1I72_15435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I72_15435	COG0596	Alpha beta hydrolase
H1I72_15445	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H1I72_15450	COG2223	nitrite transmembrane transporter activity
H1I72_15470	COG1196	nuclear chromosome segregation
H1I72_15480	COG0730	response to heat
H1I72_15495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H1I72_15505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I72_15565	COG0489	protein tyrosine kinase activity
H1I72_15575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I72_15575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I72_15605	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H1I72_15610	COG2081	HI0933 family
H1I72_15640	COG0583	DNA-binding transcription factor activity
H1I72_15660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1I72_15665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I72_15695	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H1I72_15735	COG0745	RESPONSE REGULATOR receiver
H1I72_15755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H1I72_15765	COG2205	protein histidine kinase activity
H1I72_15835	COG4993	Dehydrogenase
H1I72_15860	COG0384	phenazine biosynthesis protein PhzF
H1I72_15880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I72_15895	COG0583	DNA-binding transcription factor activity
H1I72_15925	COG0583	DNA-binding transcription factor activity
H1I72_15940	COG0583	DNA-binding transcription factor activity
H1I72_15945	COG1053	succinate dehydrogenase
H1I72_15955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H1I72_15960	COG2814	Major facilitator Superfamily
H1I72_15965	COG1960	acyl-CoA dehydrogenase activity
H1I72_15975	COG1063	alcohol dehydrogenase
H1I72_16005	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H1I72_16010	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H1I72_16015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I72_16030	COG3667	copper resistance
H1I72_16035	COG2132	Multicopper oxidase
H1I72_16045	COG0561	phosphatase activity
H1I72_16050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H1I72_16075	COG1214	PFAM Peptidase M22, glycoprotease
H1I72_16125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1I72_16135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H1I72_16140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H1I72_16145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H1I72_16205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I72_16215	COG1846	Transcriptional regulator
H1I72_16220	COG1764	response to oxidative stress
H1I72_16260	COG0037	tRNA processing
H1I72_16270	COG0248	Ppx GppA phosphatase
H1I72_16300	COG0072	phenylalanine-tRNA ligase activity
H1I72_16340	COG1238	metal cluster binding
H1I72_16345	COG0625	glutathione transferase activity
H1I72_16360	COG0318	PFAM AMP-dependent synthetase and ligase
H1I72_16365	COG3028	Belongs to the UPF0307 family
H1I72_16370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I72_16390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H1I72_16395	COG0617	tRNA 3'-terminal CCA addition
H1I72_16400	COG1555	photosystem II stabilization
H1I72_16405	COG3956	TIGRFAM MazG family protein
H1I72_16415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I72_16440	COG1024	Enoyl-CoA hydratase
H1I72_16445	COG2084	Dehydrogenase
H1I72_16450	COG3622	Belongs to the hyi family
H1I72_16490	COG2814	Major facilitator Superfamily
H1I72_16495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I72_16505	COG0583	DNA-binding transcription factor activity
H1I72_16515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H1I72_16530	COG0084	hydrolase, TatD family'
H1I72_16545	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H1I72_16575	COG0440	acetolactate synthase activity
H1I72_16580	COG0028	Belongs to the TPP enzyme family
H1I72_16605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I72_16610	COG0577	efflux transmembrane transporter activity
H1I72_16610	COG1136	(ABC) transporter
H1I72_16615	COG1538	Outer membrane efflux protein
H1I72_16630	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H1I72_16635	COG1162	GTPase activity
H1I72_16645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1I72_16665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1I72_16670	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_16710	COG2986	histidine ammonia-lyase
H1I72_16725	COG0318	PFAM AMP-dependent synthetase and ligase
H1I72_16735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1I72_16780	COG1426	Protein conserved in bacteria
H1I72_16815	COG0793	Belongs to the peptidase S41A family
H1I72_16830	COG2267	carboxylic ester hydrolase activity
H1I72_16845	COG3265	gluconokinase activity
H1I72_16855	COG0800	Aldolase
H1I72_16865	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H1I72_16875	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I72_16875	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I72_16895	COG0740	serine-type endopeptidase activity
H1I72_16905	COG4774	siderophore transport
H1I72_16915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1I72_16925	COG2813	Specifically methylates the guanine in position
H1I72_16925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I72_17025	COG0788	formyltetrahydrofolate deformylase activity
H1I72_17050	COG4651	solute:proton antiporter activity
H1I72_17050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I72_17070	COG0724	RNA recognition motif
H1I72_17075	COG0210	DNA helicase
H1I72_17100	COG1733	regulation of RNA biosynthetic process
H1I72_17110	COG2900	Belongs to the SlyX family
H1I72_17115	COG0488	(ABC) transporter
H1I72_17120	COG1280	lysine exporter protein (LysE YggA)
H1I72_17125	COG1560	Kdo2-lipid A biosynthetic process
H1I72_17135	COG1301	dicarboxylic acid transport
H1I72_17190	COG0473	3-isopropylmalate dehydrogenase activity
H1I72_17255	COG0583	DNA-binding transcription factor activity
H1I72_17265	COG0625	glutathione transferase activity
H1I72_17270	COG2378	regulation of single-species biofilm formation
H1I72_17275	COG0546	phosphoglycolate phosphatase activity
H1I72_17285	COG1530	ribonuclease E activity
H1I72_17290	COG0318	PFAM AMP-dependent synthetase and ligase
H1I72_17305	COG0583	DNA-binding transcription factor activity
H1I72_17310	COG4221	oxidoreductase activity
H1I72_17315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1I72_17325	COG0534	Mate efflux family protein
H1I72_17340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H1I72_17380	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H1I72_17385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I72_17400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I72_17410	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H1I72_17410	COG0644	oxidoreductase
H1I72_17415	COG0425	Belongs to the sulfur carrier protein TusA family
H1I72_17420	COG4535	Mg2 and Co2 transporter CorC
H1I72_17430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I72_17450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H1I72_17455	COG0475	glutathione-regulated potassium exporter activity
H1I72_17455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I72_17460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H1I72_17475	COG0789	Transcriptional regulator
H1I72_17480	COG0598	Magnesium transport protein CorA
H1I72_17500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I72_17510	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H1I72_17530	COG2226	methyltransferase
H1I72_17545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I72_17550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H1I72_17565	COG2111	Na H antiporter
H1I72_17565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I72_17570	COG1006	Multisubunit Na H antiporter MnhC subunit
H1I72_17575	COG0651	ATP synthesis coupled electron transport
H1I72_17580	COG1863	multisubunit Na H antiporter MnhE subunit
H1I72_17585	COG2212	antiporter activity
H1I72_17590	COG1320	monovalent cation:proton antiporter activity
H1I72_17605	COG0195	Participates in both transcription termination and antitermination
H1I72_17655	COG0237	dephospho-CoA kinase activity
H1I72_17665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I72_17690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H1I72_17720	COG2169	Transcriptional regulator
H1I72_17720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I72_17725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H1I72_17790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H1I72_17805	COG0326	Molecular chaperone. Has ATPase activity
H1I72_17820	COG2056	Na+-H+ antiporter family
H1I72_17825	COG0596	Alpha beta hydrolase
H1I72_17920	COG0546	phosphoglycolate phosphatase activity
H1I72_17925	COG1716	ATPase activity
H1I72_17970	COG0181	hydroxymethylbilane synthase activity
H1I72_17980	COG3275	phosphorelay sensor kinase activity
H1I72_18000	COG1538	Outer membrane efflux protein
H1I72_18030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I72_18035	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H1I72_18040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I72_18045	COG0772	Belongs to the SEDS family
H1I72_18070	COG4974	Belongs to the 'phage' integrase family
H1I72_18075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I72_18085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H1I72_18095	COG2197	response regulator
H1I72_18115	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H1I72_18120	COG0795	lipopolysaccharide-transporting ATPase activity
H1I72_18160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I72_18160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I72_18170	COG0004	ammonium transporteR
H1I72_18175	COG0347	Belongs to the P(II) protein family
H1I72_18185	COG0606	chelatase, subunit chli
H1I72_18245	COG0589	response to stress
H1I72_18275	COG0606	chelatase, subunit chli
H1I72_18280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I72_18290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I72_18305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H1I72_18335	COG2860	membrane
H1I72_18345	COG1253	flavin adenine dinucleotide binding
H1I72_18365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1I72_18400	COG0655	NAD(P)H dehydrogenase (quinone) activity
H1I72_18410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H1I72_18445	COG1309	transcriptional regulator
H1I72_18480	COG0758	DNA mediated transformation
H1I72_18490	COG0697	spore germination
H1I72_18495	COG1309	transcriptional regulator
H1I72_18510	COG0386	Belongs to the glutathione peroxidase family
H1I72_18575	COG1121	(ABC) transporter
H1I72_18580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1I72_18585	COG1280	lysine exporter protein (LysE YggA)
H1I72_18590	COG2837	iron assimilation
H1I72_18600	COG0281	malic enzyme
H1I72_18645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I72_18645	COG0519	Catalyzes the synthesis of GMP from XMP
H1I72_18655	COG2259	Doxx family
H1I72_18660	COG0586	Pfam SNARE associated Golgi protein
H1I72_18675	COG1192	Involved in chromosome partitioning
H1I72_18685	COG0271	Belongs to the BolA IbaG family
H1I72_18705	COG2267	carboxylic ester hydrolase activity
H1I72_18725	COG0318	PFAM AMP-dependent synthetase and ligase
H1I72_18725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I72_18725	COG0300	oxidoreductase activity
H1I72_18725	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_18725	COG3321	synthase
H1I72_18730	COG1960	acyl-CoA dehydrogenase activity
H1I72_18740	COG2197	response regulator
H1I72_18750	COG3916	Acyl-homoserine-lactone synthase
H1I72_18755	COG0477	Major facilitator Superfamily
H1I72_18760	COG1024	Enoyl-CoA hydratase
H1I72_18765	COG1024	Enoyl-CoA hydratase
H1I72_18770	COG1960	acyl-CoA dehydrogenase activity
H1I72_18800	COG1113	amino acid transport
H1I72_18805	COG0251	oxidation-reduction process
H1I72_18845	COG0564	pseudouridine synthase activity
H1I72_18905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H1I72_18920	COG1802	Transcriptional regulator
H1I72_18930	COG1448	Aminotransferase
H1I72_18935	COG0277	FAD linked oxidase domain protein
H1I72_18945	COG2186	Transcriptional regulator
H1I72_18955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I72_18960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I72_18975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H1I72_18980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1I72_18985	COG1216	Glycosyl transferase, family 2
H1I72_19015	COG2089	acid synthase
H1I72_19030	COG1083	cytidylyl-transferase
H1I72_19040	COG1086	Polysaccharide biosynthesis protein
H1I72_19045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H1I72_19050	COG1596	polysaccharide export
H1I72_19075	COG0728	peptidoglycan biosynthetic process
H1I72_19080	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1I72_19135	COG0546	phosphoglycolate phosphatase activity
H1I72_19140	COG1028	Short-chain dehydrogenase reductase Sdr
H1I72_19160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I72_19165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I72_19170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I72_19175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I72_19180	COG1116	anion transmembrane transporter activity
H1I72_19185	COG1309	transcriptional regulator
H1I72_19190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1I72_19200	COG0196	riboflavin kinase activity
H1I72_19205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H1I72_19215	COG1047	Peptidyl-prolyl cis-trans
H1I72_19255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H1I72_19260	COG0657	acetylesterase activity
H1I72_19310	COG2951	lytic endotransglycosylase activity
H1I72_19315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H1I72_19330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H1I72_19340	COG0671	phosphoesterase, PA-phosphatase related
H1I72_19345	COG0861	Integral membrane protein TerC family
H1I72_19355	COG0754	glutathionylspermidine amidase activity
H1I72_19365	COG0402	S-adenosylhomocysteine deaminase activity
H1I72_19380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I72_19385	COG1230	cation diffusion facilitator family transporter
H1I72_19400	COG0706	membrane insertase activity