locus-tag	class	description
H1I73_00010	COG0592	DNA-directed DNA polymerase activity
H1I73_00020	COG0187	DNA topoisomerase II activity
H1I73_00030	COG0586	Pfam SNARE associated Golgi protein
H1I73_00035	COG0488	(ABC) transporter
H1I73_00060	COG0596	Alpha beta hydrolase
H1I73_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H1I73_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H1I73_00110	COG0733	neurotransmitter:sodium symporter activity
H1I73_00150	COG2233	PERMEase
H1I73_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I73_00200	COG2814	Major facilitator Superfamily
H1I73_00205	COG0656	L-ascorbic acid biosynthetic process
H1I73_00210	COG0583	DNA-binding transcription factor activity
H1I73_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I73_00230	COG1064	alcohol dehydrogenase
H1I73_00235	COG2818	Glycosylase
H1I73_00250	COG1194	a g-specific adenine glycosylase
H1I73_00270	COG2983	Belongs to the UPF0260 family
H1I73_00275	COG2133	pyrroloquinoline quinone binding
H1I73_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H1I73_00285	COG2116	formate transmembrane transporter activity
H1I73_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I73_00310	COG1335	isochorismatase
H1I73_00315	COG0385	Bile acid
H1I73_00320	COG0534	Mate efflux family protein
H1I73_00325	COG1683	Conserved Protein
H1I73_00345	COG0625	glutathione transferase activity
H1I73_00355	COG1113	amino acid transport
H1I73_00365	COG0523	cobalamin synthesis protein
H1I73_00375	COG2188	Transcriptional regulator
H1I73_00405	COG0010	Belongs to the arginase family
H1I73_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I73_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1I73_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H1I73_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H1I73_00540	COG0534	Mate efflux family protein
H1I73_00545	COG0436	Aminotransferase
H1I73_00550	COG2733	membrane
H1I73_00565	COG2918	glutathione biosynthetic process
H1I73_00580	COG0791	NLP P60 protein
H1I73_00580	COG1388	LysM domain
H1I73_00595	COG3150	esterase
H1I73_00605	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H1I73_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I73_00630	COG2233	PERMEase
H1I73_00635	COG2351	hydroxyisourate hydrolase activity
H1I73_00670	COG3706	GGDEF domain
H1I73_00685	COG1393	Belongs to the ArsC family
H1I73_00690	COG0708	Exodeoxyribonuclease III
H1I73_00710	COG0189	ligase activity
H1I73_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H1I73_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1I73_00755	COG4942	peptidase
H1I73_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I73_00775	COG2119	membrane
H1I73_00780	COG4774	siderophore transport
H1I73_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I73_00785	COG0426	domain, Protein
H1I73_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H1I73_00830	COG1902	pentaerythritol trinitrate reductase activity
H1I73_00835	COG1519	Transferase
H1I73_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I73_00845	COG0668	transmembrane transport
H1I73_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I73_00860	COG1335	isochorismatase
H1I73_00865	COG1522	sequence-specific DNA binding
H1I73_00870	COG3328	transposase activity
H1I73_00895	COG2205	protein histidine kinase activity
H1I73_00895	COG2198	Histidine kinase
H1I73_00895	COG0784	Response regulator, receiver
H1I73_00900	COG3162	membrane
H1I73_00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I73_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I73_00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H1I73_00940	COG1309	transcriptional regulator
H1I73_00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I73_00960	COG0352	thiamine-phosphate diphosphorylase activity
H1I73_00960	COG0351	phosphomethylpyrimidine kinase
H1I73_00970	COG2814	Major facilitator Superfamily
H1I73_00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I73_00995	COG1113	amino acid transport
H1I73_01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I73_01010	COG1012	belongs to the aldehyde dehydrogenase family
H1I73_01020	COG1335	isochorismatase
H1I73_01050	COG2814	Major facilitator Superfamily
H1I73_01055	COG0583	DNA-binding transcription factor activity
H1I73_01075	COG0667	Aldo Keto reductase
H1I73_01105	COG1733	regulation of RNA biosynthetic process
H1I73_01110	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I73_01175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H1I73_01190	COG2329	Antibiotic biosynthesis monooxygenase
H1I73_01220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H1I73_01250	COG0427	acetyl-CoA hydrolase
H1I73_01275	COG0659	secondary active sulfate transmembrane transporter activity
H1I73_01280	COG4221	oxidoreductase activity
H1I73_01285	COG2873	o-acetylhomoserine
H1I73_01375	COG0833	amino acid
H1I73_01420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H1I73_01425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H1I73_01440	COG2226	methyltransferase
H1I73_01490	COG0069	glutamate synthase activity
H1I73_01490	COG0070	glutamate synthase
H1I73_01490	COG0067	glutamate synthase
H1I73_01495	COG0493	'glutamate synthase
H1I73_01505	COG1704	LemA family
H1I73_01510	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H1I73_01530	COG3307	-O-antigen
H1I73_01550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I73_01565	COG0194	GDP metabolic process
H1I73_01615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H1I73_01635	COG5380	lipid catabolic process
H1I73_01640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H1I73_01665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1I73_01670	COG0277	FAD linked oxidase domain protein
H1I73_01680	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H1I73_01685	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I73_01700	COG1289	transmembrane transporter activity
H1I73_01710	COG0628	permease
H1I73_01715	COG1192	Involved in chromosome partitioning
H1I73_01745	COG0833	amino acid
H1I73_01750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I73_01755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I73_01765	COG1012	belongs to the aldehyde dehydrogenase family
H1I73_01805	COG0583	DNA-binding transcription factor activity
H1I73_01850	COG0517	IMP dehydrogenase activity
H1I73_01855	COG1983	PspC domain protein
H1I73_01865	COG1960	acyl-CoA dehydrogenase activity
H1I73_01880	COG0408	coproporphyrinogen oxidase activity
H1I73_01900	COG0513	Belongs to the DEAD box helicase family
H1I73_01910	COG1127	ABC transporter
H1I73_01915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H1I73_01925	COG2854	intermembrane phospholipid transfer
H1I73_01935	COG0598	Magnesium transport protein CorA
H1I73_01945	COG0494	nUDIX hydrolase
H1I73_01950	COG1040	competence protein
H1I73_01955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H1I73_01975	COG1946	Acyl-CoA thioesterase
H1I73_01980	COG1301	dicarboxylic acid transport
H1I73_01995	COG1959	2 iron, 2 sulfur cluster binding
H1I73_02000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I73_02000	COG1017	nitric oxide dioxygenase activity
H1I73_02005	COG0433	COG0433 Predicted ATPase
H1I73_02010	COG0626	cystathionine gamma-synthase activity
H1I73_02165	COG1960	acyl-CoA dehydrogenase activity
H1I73_02170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H1I73_02200	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H1I73_02205	COG0339	signal peptide processing
H1I73_02210	COG0557	exoribonuclease II activity
H1I73_02255	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1I73_02260	COG2169	Transcriptional regulator
H1I73_02265	COG0697	spore germination
H1I73_02270	COG1295	ribonuclease BN
H1I73_02305	COG1702	phosphate starvation-inducible protein PhoH
H1I73_02315	COG0739	heme binding
H1I73_02315	COG0741	lytic transglycosylase activity
H1I73_02315	COG1196	nuclear chromosome segregation
H1I73_02345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H1I73_02350	COG1183	phosphatidylcholine synthase activity
H1I73_02395	COG1960	acyl-CoA dehydrogenase activity
H1I73_02400	COG1309	transcriptional regulator
H1I73_02415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I73_02420	COG1960	acyl-CoA dehydrogenase activity
H1I73_02440	COG2969	positive regulation of protein catabolic process
H1I73_02450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H1I73_02465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1I73_02470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H1I73_02490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1I73_02500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I73_02505	COG1408	metallophosphoesterase
H1I73_02515	COG2199	diguanylate cyclase activity
H1I73_02575	COG1607	acyl-coa hydrolase
H1I73_02605	COG2350	Protein conserved in bacteria
H1I73_02615	COG0613	PHP domain protein
H1I73_02620	COG3781	membrane
H1I73_02630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H1I73_02635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H1I73_02645	COG1862	Preprotein translocase
H1I73_02675	COG2205	protein histidine kinase activity
H1I73_02680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H1I73_02700	COG0726	polysaccharide deacetylase
H1I73_02705	COG0463	Glycosyl transferase, family 2
H1I73_02710	COG0438	transferase activity, transferring glycosyl groups
H1I73_02775	COG0625	glutathione transferase activity
H1I73_02780	COG0583	DNA-binding transcription factor activity
H1I73_02785	COG1960	acyl-CoA dehydrogenase activity
H1I73_02790	COG1960	acyl-CoA dehydrogenase activity
H1I73_02800	COG2205	protein histidine kinase activity
H1I73_02805	COG0745	RESPONSE REGULATOR receiver
H1I73_02810	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H1I73_02830	COG2096	Adenosyltransferase
H1I73_02880	COG0285	dihydrofolate synthase activity
H1I73_02900	COG0450	alkyl hydroperoxide reductase
H1I73_02915	COG0477	Major facilitator Superfamily
H1I73_02920	COG1272	protein, Hemolysin III
H1I73_02950	COG0183	Belongs to the thiolase family
H1I73_02955	COG2207	Transcriptional regulator
H1I73_02975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I73_02995	COG0183	Belongs to the thiolase family
H1I73_03005	COG2885	chlorophyll binding
H1I73_03005	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H1I73_03015	COG1690	Belongs to the RtcB family
H1I73_03020	COG0833	amino acid
H1I73_03030	COG2233	PERMEase
H1I73_03035	COG1217	gtp-binding protein TYPA
H1I73_03060	COG2094	Belongs to the DNA glycosylase MPG family
H1I73_03065	COG4772	TonB-dependent receptor
H1I73_03080	COG1902	pentaerythritol trinitrate reductase activity
H1I73_03095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I73_03100	COG0354	folic acid binding
H1I73_03110	COG3189	MarR family transcriptional regulator
H1I73_03115	COG2824	Alkylphosphonate utilization operon protein PhnA
H1I73_03120	COG3422	double-strand break repair
H1I73_03160	COG0840	transmembrane signaling receptor activity
H1I73_03180	COG5510	response to toxic substance
H1I73_03190	COG2832	Protein of unknown function (DUF454)
H1I73_03195	COG1376	ErfK ybiS ycfS ynhG family protein
H1I73_03235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H1I73_03245	COG1289	transmembrane transporter activity
H1I73_03250	COG2814	Major facilitator Superfamily
H1I73_03270	COG1115	amino acid carrier protein
H1I73_03275	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I73_03280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I73_03285	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H1I73_03325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I73_03335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I73_03340	COG1077	Cell shape determining protein MreB Mrl
H1I73_03345	COG1792	Involved in formation and maintenance of cell shape
H1I73_03350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H1I73_03355	COG0424	maF-like protein
H1I73_03360	COG1530	ribonuclease E activity
H1I73_03370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I73_03380	COG0560	Phosphoserine phosphatase
H1I73_03390	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I73_03415	COG2207	Transcriptional regulator
H1I73_03435	COG1113	amino acid transport
H1I73_03440	COG2828	Protein conserved in bacteria
H1I73_03445	COG0142	geranyltranstransferase activity
H1I73_03450	COG2315	Protein conserved in bacteria
H1I73_03465	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I73_03500	COG0745	RESPONSE REGULATOR receiver
H1I73_03505	COG0642	Histidine kinase
H1I73_03515	COG0004	ammonium transporteR
H1I73_03520	COG0583	DNA-binding transcription factor activity
H1I73_03540	COG0525	valine-tRNA ligase activity
H1I73_03550	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_03560	COG0393	Putative heavy-metal-binding
H1I73_03565	COG0393	Putative heavy-metal-binding
H1I73_03570	COG1538	Outer membrane efflux protein
H1I73_03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I73_03585	COG0671	phosphoesterase, PA-phosphatase related
H1I73_03615	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H1I73_03630	COG1648	precorrin-2 dehydrogenase activity
H1I73_03630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H1I73_03635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H1I73_03640	COG1733	regulation of RNA biosynthetic process
H1I73_03650	COG0531	amino acid
H1I73_03665	COG0321	lipoyl(octanoyl) transferase activity
H1I73_03670	COG2921	Belongs to the UPF0250 family
H1I73_03710	COG2009	succinate dehydrogenase
H1I73_03715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H1I73_03720	COG1053	succinate dehydrogenase
H1I73_03725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H1I73_03750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I73_03770	COG2354	Protein conserved in bacteria
H1I73_03775	COG2321	neutral zinc metallopeptidase
H1I73_03830	COG2843	Capsule synthesis protein
H1I73_03845	COG0589	response to stress
H1I73_03890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I73_03895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H1I73_03945	COG0477	Major facilitator Superfamily
H1I73_03950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H1I73_03965	COG1597	lipid kinase activity
H1I73_03970	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I73_04000	COG0584	glycerophosphoryl diester phosphodiesterase
H1I73_04020	COG0741	lytic transglycosylase activity
H1I73_04040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1I73_04055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I73_04080	COG0778	Nitroreductase
H1I73_04095	COG1929	Belongs to the glycerate kinase type-1 family
H1I73_04100	COG0243	molybdopterin cofactor binding
H1I73_04105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H1I73_04110	COG3339	Conserved Protein
H1I73_04120	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H1I73_04135	COG1113	amino acid transport
H1I73_04145	COG0019	diaminopimelate decarboxylase activity
H1I73_04155	COG1280	lysine exporter protein (LysE YggA)
H1I73_04160	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H1I73_04190	COG0463	Glycosyl transferase, family 2
H1I73_04210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I73_04245	COG4591	ABC-type transport system involved in lipoprotein release permease component
H1I73_04250	COG1136	(ABC) transporter
H1I73_04255	COG2333	competence protein COMEC
H1I73_04255	COG0658	competence protein
H1I73_04265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H1I73_04265	COG0616	signal peptide processing
H1I73_04270	COG0596	Alpha beta hydrolase
H1I73_04275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H1I73_04285	COG0628	permease
H1I73_04320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I73_04340	COG0823	Involved in the tonB-independent uptake of proteins
H1I73_04360	COG0824	Thioesterase
H1I73_04365	COG1473	amidohydrolase
H1I73_04385	COG0047	phosphoribosylformylglycinamidine synthase activity
H1I73_04385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1I73_04390	COG2814	Major facilitator Superfamily
H1I73_04400	COG1024	Enoyl-CoA hydratase
H1I73_04405	COG1051	belongs to the nudix hydrolase family
H1I73_04405	COG1056	cytidyltransferase-related domain
H1I73_04415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H1I73_04430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H1I73_04445	COG4625	pathogenesis
H1I73_04450	COG0583	DNA-binding transcription factor activity
H1I73_04455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1I73_04460	COG4208	sulfate ABC transporter
H1I73_04465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H1I73_04475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H1I73_04480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1I73_04485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H1I73_04520	COG0681	Belongs to the peptidase S26 family
H1I73_04535	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H1I73_04545	COG1381	Involved in DNA repair and RecF pathway recombination
H1I73_04550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H1I73_04560	COG4221	oxidoreductase activity
H1I73_04590	COG0436	Aminotransferase
H1I73_04610	COG0556	nucleotide-excision repair
H1I73_04665	COG2070	2-Nitropropane dioxygenase
H1I73_04695	COG1215	transferase activity, transferring glycosyl groups
H1I73_04710	COG0415	Belongs to the DNA photolyase family
H1I73_04720	COG1252	NADH dehydrogenase
H1I73_04725	COG1686	Belongs to the peptidase S11 family
H1I73_04740	COG1187	pseudouridine synthase activity
H1I73_04765	COG0477	Major facilitator Superfamily
H1I73_04770	COG0583	DNA-binding transcription factor activity
H1I73_04775	COG1823	symporter activity
H1I73_04785	COG0612	Peptidase, M16
H1I73_04810	COG0352	thiamine-phosphate diphosphorylase activity
H1I73_04845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I73_04860	COG1309	transcriptional regulator
H1I73_04870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I73_04875	COG0076	glutamate decarboxylase activity
H1I73_04885	COG1522	sequence-specific DNA binding
H1I73_04890	COG3961	Belongs to the TPP enzyme family
H1I73_04895	COG1113	amino acid transport
H1I73_04900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I73_04905	COG0573	inorganic phosphate transmembrane transporter activity
H1I73_04915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1I73_04920	COG0616	signal peptide processing
H1I73_04930	COG3328	transposase activity
H1I73_04960	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H1I73_04965	COG1686	Belongs to the peptidase S11 family
H1I73_04990	COG0583	DNA-binding transcription factor activity
H1I73_04995	COG1067	ATP-dependent peptidase activity
H1I73_05040	COG1966	Carbon starvation protein
H1I73_05045	COG2879	small protein
H1I73_05075	COG2508	Transcriptional regulator
H1I73_05075	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H1I73_05095	COG1113	amino acid transport
H1I73_05100	COG0583	DNA-binding transcription factor activity
H1I73_05105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I73_05110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I73_05120	COG1012	belongs to the aldehyde dehydrogenase family
H1I73_05125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I73_05130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I73_05130	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H1I73_05165	COG2814	Major facilitator Superfamily
H1I73_05170	COG4948	Mandelate Racemase Muconate Lactonizing
H1I73_05180	COG1309	transcriptional regulator
H1I73_05200	COG1741	Belongs to the pirin family
H1I73_05210	COG2964	Protein conserved in bacteria
H1I73_05225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I73_05230	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I73_05235	COG4605	iron ion homeostasis
H1I73_05240	COG4604	ABC transporter, ATP-binding protein
H1I73_05245	COG4607	ABC-type enterochelin transport system periplasmic component
H1I73_05250	COG4774	siderophore transport
H1I73_05260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I73_05265	COG1021	2,3-dihydroxybenzoate-AMP ligase
H1I73_05270	COG3433	isochorismatase activity
H1I73_05270	COG1535	isochorismatase
H1I73_05285	COG1132	(ABC) transporter
H1I73_05290	COG1132	(ABC) transporter
H1I73_05295	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H1I73_05305	COG1169	isochorismate synthase
H1I73_05320	COG3739	integral membrane protein
H1I73_05345	COG0302	gtp cyclohydrolase
H1I73_05355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1I73_05385	COG0308	aminopeptidase N
H1I73_05390	COG0512	Glutamine amidotransferase of anthranilate synthase
H1I73_05405	COG0174	glutamine synthetase
H1I73_05450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H1I73_05455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H1I73_05460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I73_05480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I73_05485	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H1I73_05490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H1I73_05505	COG1960	acyl-CoA dehydrogenase activity
H1I73_05510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I73_05515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I73_05525	COG2223	nitrite transmembrane transporter activity
H1I73_05535	COG0024	Methionine aminopeptidase
H1I73_05540	COG0052	Belongs to the universal ribosomal protein uS2 family
H1I73_05555	COG2207	Transcriptional regulator
H1I73_05585	COG0772	Belongs to the SEDS family
H1I73_05600	COG0842	Transport permease protein
H1I73_05605	COG1131	(ABC) transporter
H1I73_05650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I73_05665	COG4215	(ABC) transporter
H1I73_05670	COG4160	amino acid transport
H1I73_05675	COG4598	ABC transporter
H1I73_05685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I73_05690	COG0826	peptidase U32
H1I73_05695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I73_05710	COG1720	tRNA m6t6A37 methyltransferase activity
H1I73_05720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H1I73_05735	COG0642	Histidine kinase
H1I73_05745	COG0494	nUDIX hydrolase
H1I73_05755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1I73_05760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H1I73_05765	COG3139	Protein of unknown function (DUF1315)
H1I73_05770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1I73_05775	COG1301	dicarboxylic acid transport
H1I73_05780	COG1960	acyl-CoA dehydrogenase activity
H1I73_05785	COG2819	hydrolase of the alpha beta superfamily
H1I73_05795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H1I73_05805	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1I73_05810	COG1234	tRNA 3'-trailer cleavage
H1I73_05840	COG2363	Small membrane protein
H1I73_05860	COG0513	Belongs to the DEAD box helicase family
H1I73_05870	COG0778	Nitroreductase
H1I73_05900	COG1286	toxin biosynthetic process
H1I73_05925	COG4783	chaperone-mediated protein folding
H1I73_05930	COG1610	YqeY-like protein
H1I73_06030	COG3111	PFAM Bacterial OB fold (BOF) protein
H1I73_06055	COG3243	poly(R)-hydroxyalkanoic acid synthase
H1I73_06060	COG0786	glutamate:sodium symporter activity
H1I73_06070	COG2186	Transcriptional regulator
H1I73_06120	COG0477	Major facilitator Superfamily
H1I73_06155	COG2995	paraquat-inducible protein a
H1I73_06160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H1I73_06160	COG3008	intermembrane lipid transfer
H1I73_06180	COG0482	sulfurtransferase activity
H1I73_06195	COG0488	(ABC) transporter
H1I73_06200	COG3173	Aminoglycoside phosphotransferase
H1I73_06210	COG2433	Pfam Transposase IS66
H1I73_06250	COG1301	dicarboxylic acid transport
H1I73_06260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I73_06265	COG2011	ABC-type metal ion transport system permease component
H1I73_06270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I73_06275	COG1464	Belongs to the NlpA lipoprotein family
H1I73_06280	COG0151	Belongs to the GarS family
H1I73_06285	COG0138	bifunctional purine biosynthesis protein purh
H1I73_06290	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H1I73_06320	COG2308	Evidence 4 Homologs of previously reported genes of
H1I73_06330	COG1305	Transglutaminase-like
H1I73_06340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1I73_06345	COG0305	Participates in initiation and elongation during chromosome replication
H1I73_06370	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H1I73_06380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1I73_06385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H1I73_06410	COG1649	PFAM Uncharacterised BCR, COG1649
H1I73_06410	COG0726	polysaccharide deacetylase
H1I73_06415	COG1215	transferase activity, transferring glycosyl groups
H1I73_06420	COG3658	cytochrome
H1I73_06430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I73_06445	COG0583	DNA-binding transcription factor activity
H1I73_06465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I73_06470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I73_06485	COG1960	acyl-CoA dehydrogenase activity
H1I73_06490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I73_06495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I73_06520	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H1I73_06525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H1I73_06535	COG2205	protein histidine kinase activity
H1I73_06540	COG0745	RESPONSE REGULATOR receiver
H1I73_06565	COG0729	surface antigen
H1I73_06590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I73_06595	COG2814	Major facilitator Superfamily
H1I73_06610	COG0583	DNA-binding transcription factor activity
H1I73_06625	COG1187	pseudouridine synthase activity
H1I73_06645	COG0802	atpase or kinase
H1I73_06650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H1I73_06660	COG1923	regulation of RNA biosynthetic process
H1I73_06665	COG0697	spore germination
H1I73_06680	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I73_06690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I73_06695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I73_06695	COG0519	Catalyzes the synthesis of GMP from XMP
H1I73_06700	COG4302	ethanolamine ammonia-lyase activity
H1I73_06705	COG4303	Ethanolamine ammonia lyase large subunit
H1I73_06710	COG0531	amino acid
H1I73_06730	COG1454	alcohol dehydrogenase
H1I73_06735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I73_06745	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H1I73_06765	COG0308	aminopeptidase N
H1I73_06795	COG1605	Chorismate mutase
H1I73_06810	COG1309	transcriptional regulator
H1I73_06820	COG0668	transmembrane transport
H1I73_06855	COG4773	Receptor
H1I73_06875	COG0488	(ABC) transporter
H1I73_06880	COG0589	response to stress
H1I73_06925	COG3135	benzoate transporter
H1I73_06930	COG1522	sequence-specific DNA binding
H1I73_06940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H1I73_06945	COG0583	DNA-binding transcription factor activity
H1I73_06955	COG0183	Belongs to the thiolase family
H1I73_06965	COG2030	dehydratase
H1I73_06970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I73_06985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H1I73_06995	COG0824	Thioesterase
H1I73_07000	COG1454	alcohol dehydrogenase
H1I73_07010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H1I73_07030	COG0069	glutamate synthase activity
H1I73_07195	COG5410	chromosome segregation
H1I73_07380	COG2814	Major facilitator Superfamily
H1I73_07395	COG0511	ligase activity, forming carbon-carbon bonds
H1I73_07415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I73_07415	COG1116	anion transmembrane transporter activity
H1I73_07420	COG0745	RESPONSE REGULATOR receiver
H1I73_07430	COG2146	nitrite reductase [NAD(P)H] activity
H1I73_07430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I73_07435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I73_07440	COG0243	molybdopterin cofactor binding
H1I73_07450	COG0243	molybdopterin cofactor binding
H1I73_07455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H1I73_07470	COG0521	Mo-molybdopterin cofactor biosynthetic process
H1I73_07470	COG0315	cyclic pyranopterin monophosphate synthase activity
H1I73_07475	COG0303	'Molybdopterin
H1I73_07485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I73_07490	COG0697	spore germination
H1I73_07510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H1I73_07515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I73_07570	COG2204	response regulator
H1I73_07575	COG3852	Histidine kinase
H1I73_07595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H1I73_07600	COG0575	Belongs to the CDS family
H1I73_07655	COG2137	regulation of response to DNA damage stimulus
H1I73_07665	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H1I73_07670	COG1011	Hydrolase
H1I73_07695	COG1522	sequence-specific DNA binding
H1I73_07705	COG1113	amino acid transport
H1I73_07720	COG0659	secondary active sulfate transmembrane transporter activity
H1I73_07725	COG2135	peptidase activity
H1I73_07740	COG3300	MHYT domain
H1I73_07740	COG5001	Diguanylate cyclase
H1I73_07760	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H1I73_07760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I73_07760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I73_07765	COG1105	Belongs to the carbohydrate kinase PfkB family
H1I73_07770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I73_07770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1I73_07800	COG0024	Methionine aminopeptidase
H1I73_07805	COG0583	DNA-binding transcription factor activity
H1I73_07815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H1I73_07820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I73_07825	COG0517	IMP dehydrogenase activity
H1I73_07825	COG0516	GMP reductase activity
H1I73_07860	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H1I73_07875	COG4890	Cyd operon protein YbgT
H1I73_07880	COG1294	oxidase, subunit
H1I73_07895	COG1585	Membrane protein implicated in regulation of membrane protease activity
H1I73_07905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1I73_07910	COG4774	siderophore transport
H1I73_07925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H1I73_07930	COG0569	domain protein
H1I73_07935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I73_07965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1I73_07970	COG0542	response to heat
H1I73_07995	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I73_07995	COG1902	pentaerythritol trinitrate reductase activity
H1I73_08040	COG2323	membrane
H1I73_08045	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H1I73_08055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I73_08060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I73_08065	COG0183	Belongs to the thiolase family
H1I73_08070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H1I73_08075	COG0596	Alpha beta hydrolase
H1I73_08080	COG2271	Major facilitator Superfamily
H1I73_08085	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I73_08090	COG3485	protocatechuate 3,4-dioxygenase
H1I73_08100	COG0710	3-dehydroquinate dehydratase activity
H1I73_08105	COG3420	alginic acid biosynthetic process
H1I73_08110	COG3659	wide pore channel activity
H1I73_08115	COG4993	Dehydrogenase
H1I73_08125	COG2391	methyltransferase activity
H1I73_08140	COG1414	Transcriptional regulator
H1I73_08145	COG0583	DNA-binding transcription factor activity
H1I73_08150	COG1960	acyl-CoA dehydrogenase activity
H1I73_08175	COG2814	Major facilitator Superfamily
H1I73_08185	COG0154	amidase activity
H1I73_08205	COG4638	Rieske (2fe-2S)
H1I73_08215	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_08225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I73_08235	COG3733	amine oxidase
H1I73_08245	COG1012	belongs to the aldehyde dehydrogenase family
H1I73_08255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I73_08260	COG0183	Belongs to the thiolase family
H1I73_08265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I73_08270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I73_08280	COG4829	muconolactone delta-isomerase
H1I73_08285	COG4948	Mandelate Racemase Muconate Lactonizing
H1I73_08290	COG0583	DNA-binding transcription factor activity
H1I73_08300	COG2186	Transcriptional regulator
H1I73_08340	COG1960	acyl-CoA dehydrogenase activity
H1I73_08360	COG3162	membrane
H1I73_08375	COG1012	belongs to the aldehyde dehydrogenase family
H1I73_08390	COG0753	catalase activity
H1I73_08410	COG1846	Transcriptional regulator
H1I73_08415	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I73_08415	COG1902	pentaerythritol trinitrate reductase activity
H1I73_08425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H1I73_08455	COG1309	transcriptional regulator
H1I73_08465	COG1335	isochorismatase
H1I73_08470	COG0583	DNA-binding transcription factor activity
H1I73_08480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I73_08480	COG0475	glutathione-regulated potassium exporter activity
H1I73_08490	COG1473	amidohydrolase
H1I73_08500	COG2831	hemolysin activation secretion protein
H1I73_08505	COG3210	domain, Protein
H1I73_08535	COG2188	Transcriptional regulator
H1I73_08550	COG0583	DNA-binding transcription factor activity
H1I73_08580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I73_08600	COG1566	PFAM secretion protein HlyD family protein
H1I73_08615	COG1012	belongs to the aldehyde dehydrogenase family
H1I73_08620	COG0129	dihydroxy-acid dehydratase activity
H1I73_08630	COG0583	DNA-binding transcription factor activity
H1I73_08635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1I73_08645	COG2084	Dehydrogenase
H1I73_08650	COG2207	Transcriptional regulator
H1I73_08665	COG1064	alcohol dehydrogenase
H1I73_08675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I73_08680	COG1120	ATPase activity
H1I73_08700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I73_08815	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H1I73_08865	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_08880	COG2207	Transcriptional regulator
H1I73_08890	COG2205	protein histidine kinase activity
H1I73_08895	COG0745	RESPONSE REGULATOR receiver
H1I73_08900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I73_08905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I73_08910	COG1538	Outer membrane efflux protein
H1I73_08920	COG2072	flavoprotein involved in K transport
H1I73_08940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I73_08960	COG3539	Fimbrial protein
H1I73_08990	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H1I73_09000	COG0753	catalase activity
H1I73_09015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I73_09080	COG3433	isochorismatase activity
H1I73_09080	COG1535	isochorismatase
H1I73_09085	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_09090	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H1I73_09095	COG4149	molybdate abc transporter
H1I73_09100	COG0725	ABC transporter, periplasmic molybdate-binding protein
H1I73_09110	COG4638	Rieske (2fe-2S)
H1I73_09115	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I73_09120	COG0543	2 iron, 2 sulfur cluster binding
H1I73_09120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I73_09145	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_09160	COG2207	Transcriptional regulator
H1I73_09170	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_09175	COG2610	gluconate transmembrane transporter activity
H1I73_09185	COG0583	DNA-binding transcription factor activity
H1I73_09195	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I73_09200	COG2031	fatty acid transporter
H1I73_09205	COG0183	Belongs to the thiolase family
H1I73_09210	COG0583	DNA-binding transcription factor activity
H1I73_09215	COG0583	DNA-binding transcription factor activity
H1I73_09230	COG1027	Aspartate ammonia-lyase
H1I73_09240	COG0477	Major facilitator Superfamily
H1I73_09260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I73_09265	COG4521	taurine ABC transporter
H1I73_09280	COG2188	Transcriptional regulator
H1I73_09290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H1I73_09295	COG1733	regulation of RNA biosynthetic process
H1I73_09300	COG2207	Transcriptional regulator
H1I73_09300	COG3708	Transcriptional regulator
H1I73_09315	COG0730	response to heat
H1I73_09325	COG3453	Protein conserved in bacteria
H1I73_09325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I73_09335	COG3781	membrane
H1I73_09340	COG1063	alcohol dehydrogenase
H1I73_09350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I73_09355	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I73_09360	COG0022	dehydrogenase e1 component
H1I73_09365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H1I73_09370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I73_09385	COG3706	GGDEF domain
H1I73_09400	COG0133	tryptophan synthase activity
H1I73_09410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I73_09445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H1I73_09470	COG2226	methyltransferase
H1I73_09525	COG0842	Transport permease protein
H1I73_09530	COG0842	Transport permease protein
H1I73_09535	COG1131	(ABC) transporter
H1I73_09550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I73_09555	COG4773	Receptor
H1I73_09575	COG0730	response to heat
H1I73_09580	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H1I73_09600	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H1I73_09615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I73_09655	COG4264	IucA IucC family
H1I73_09660	COG4264	IucA IucC family
H1I73_09680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1I73_09695	COG1960	acyl-CoA dehydrogenase activity
H1I73_09700	COG1960	acyl-CoA dehydrogenase activity
H1I73_09705	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I73_09710	COG2207	Transcriptional regulator
H1I73_09715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I73_09720	COG0776	regulation of translation
H1I73_09745	COG0822	iron-sulfur transferase activity
H1I73_09750	COG0316	Belongs to the HesB IscA family
H1I73_09780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H1I73_09800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I73_09805	COG0702	epimerase
H1I73_09840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1I73_09850	COG0339	signal peptide processing
H1I73_09900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H1I73_09905	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H1I73_09935	COG0776	regulation of translation
H1I73_10000	COG0084	hydrolase, TatD family'
H1I73_10020	COG1663	tetraacyldisaccharide 4'-kinase activity
H1I73_10025	COG1132	(ABC) transporter
H1I73_10035	COG0811	peptide transport
H1I73_10040	COG1475	DNA binding
H1I73_10045	COG1192	Involved in chromosome partitioning
H1I73_10055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1I73_10070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I73_10075	COG0191	fructose-bisphosphate aldolase activity
H1I73_10095	COG0424	maF-like protein
H1I73_10100	COG2850	peptidyl-arginine hydroxylation
H1I73_10110	COG0640	Transcriptional regulator
H1I73_10125	COG3619	membrane
H1I73_10135	COG1132	(ABC) transporter
H1I73_10155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H1I73_10160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I73_10170	COG0506	proline dehydrogenase activity
H1I73_10170	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I73_10170	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I73_10175	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H1I73_10190	COG3698	Phosphodiester glycosidase
H1I73_10200	COG2353	YceI-like domain
H1I73_10210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H1I73_10255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H1I73_10255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H1I73_10280	COG3539	Fimbrial protein
H1I73_10285	COG3121	Chaperone
H1I73_10310	COG0697	spore germination
H1I73_10320	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I73_10330	COG0583	DNA-binding transcription factor activity
H1I73_10350	COG1309	transcriptional regulator
H1I73_10365	COG1522	sequence-specific DNA binding
H1I73_10375	COG1126	abc transporter atp-binding protein
H1I73_10380	COG0765	amino acid transport
H1I73_10385	COG0765	amino acid transport
H1I73_10415	COG1464	Belongs to the NlpA lipoprotein family
H1I73_10425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I73_10430	COG2011	ABC-type metal ion transport system permease component
H1I73_10435	COG0012	GTP binding
H1I73_10460	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I73_10500	COG0386	Belongs to the glutathione peroxidase family
H1I73_10510	COG0436	Aminotransferase
H1I73_10565	COG0583	DNA-binding transcription factor activity
H1I73_10570	COG0798	PFAM Bile acid sodium symporter
H1I73_10575	COG0640	Transcriptional regulator
H1I73_10590	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H1I73_10600	COG0583	DNA-binding transcription factor activity
H1I73_10610	COG1953	Uracil, thiamine, allantoin
H1I73_10620	COG2175	clavaminate synthase activity
H1I73_10625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I73_10630	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H1I73_10635	COG4521	taurine ABC transporter
H1I73_10645	COG0477	Major facilitator Superfamily
H1I73_10665	COG1271	oxidase subunit
H1I73_10670	COG1294	oxidase, subunit
H1I73_10680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I73_10700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1I73_10720	COG3052	prosthetic group binding
H1I73_10725	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H1I73_10735	COG2814	Major facilitator Superfamily
H1I73_10755	COG1346	cytolysis
H1I73_10765	COG0583	DNA-binding transcription factor activity
H1I73_10770	COG0625	glutathione transferase activity
H1I73_10775	COG0625	glutathione transferase activity
H1I73_10780	COG0583	DNA-binding transcription factor activity
H1I73_10795	COG1045	serine acetyltransferase
H1I73_10800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I73_10805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H1I73_10815	COG1280	lysine exporter protein (LysE YggA)
H1I73_10830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I73_10835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I73_10840	COG1126	abc transporter atp-binding protein
H1I73_10845	COG0765	amino acid transport
H1I73_10850	COG0765	amino acid transport
H1I73_10890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1I73_10910	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_10960	COG0583	DNA-binding transcription factor activity
H1I73_10985	COG1309	transcriptional regulator
H1I73_10990	COG1960	acyl-CoA dehydrogenase activity
H1I73_10995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I73_11000	COG1024	Enoyl-CoA hydratase
H1I73_11005	COG4770	biotin carboxylase activity
H1I73_11015	COG0583	DNA-binding transcription factor activity
H1I73_11030	COG1960	acyl-CoA dehydrogenase activity
H1I73_11040	COG2814	Major facilitator Superfamily
H1I73_11050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I73_11055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I73_11060	COG2814	Major facilitator Superfamily
H1I73_11065	COG1960	acyl-CoA dehydrogenase activity
H1I73_11070	COG1024	Enoyl-CoA hydratase
H1I73_11075	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_11080	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I73_11085	COG0183	Belongs to the thiolase family
H1I73_11095	COG2814	Major facilitator Superfamily
H1I73_11105	COG1024	Enoyl-CoA hydratase
H1I73_11120	COG1960	acyl-CoA dehydrogenase activity
H1I73_11125	COG2814	Major facilitator Superfamily
H1I73_11130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I73_11135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H1I73_11150	COG3842	ATPase activity
H1I73_11155	COG1840	ABC-type Fe3 transport system, periplasmic component
H1I73_11165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I73_11170	COG1414	Transcriptional regulator
H1I73_11180	COG0583	DNA-binding transcription factor activity
H1I73_11185	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I73_11190	COG1012	belongs to the aldehyde dehydrogenase family
H1I73_11200	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I73_11210	COG1012	belongs to the aldehyde dehydrogenase family
H1I73_11215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I73_11220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I73_11225	COG2267	carboxylic ester hydrolase activity
H1I73_11245	COG3038	cytochrome b561
H1I73_11250	COG0753	catalase activity
H1I73_11280	COG2050	protein possibly involved in aromatic compounds catabolism
H1I73_11290	COG3327	negative regulation of DNA-templated transcription, initiation
H1I73_11295	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H1I73_11300	COG0183	Belongs to the thiolase family
H1I73_11305	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I73_11310	COG1024	Enoyl-CoA hydratase
H1I73_11315	COG1024	Enoyl-CoA hydratase
H1I73_11325	COG2151	metal-sulfur cluster biosynthetic enzyme
H1I73_11330	COG3396	Phenylacetate-CoA oxygenase
H1I73_11335	COG3460	Phenylacetate-CoA oxygenase
H1I73_11340	COG3396	Phenylacetate-CoA oxygenase
H1I73_11345	COG1012	belongs to the aldehyde dehydrogenase family
H1I73_11345	COG2030	dehydratase
H1I73_11350	COG1760	l-serine dehydratase
H1I73_11355	COG0531	amino acid
H1I73_11360	COG1012	belongs to the aldehyde dehydrogenase family
H1I73_11375	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I73_11385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I73_11405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I73_11415	COG0789	Transcriptional regulator
H1I73_11430	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H1I73_11445	COG2807	transmembrane transport
H1I73_11450	COG0590	tRNA wobble adenosine to inosine editing
H1I73_11565	COG1116	anion transmembrane transporter activity
H1I73_11570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I73_11580	COG0864	Transcriptional regulator
H1I73_11600	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I73_11605	COG0439	Biotin carboxylase
H1I73_11620	COG1063	alcohol dehydrogenase
H1I73_11630	COG1309	transcriptional regulator
H1I73_11650	COG0038	chloride channel
H1I73_11675	COG1914	H( )-stimulated, divalent metal cation uptake system
H1I73_11680	COG0583	DNA-binding transcription factor activity
H1I73_11730	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I73_11750	COG2814	Major facilitator Superfamily
H1I73_11760	COG1560	Kdo2-lipid A biosynthetic process
H1I73_11770	COG5006	permease, DMT superfamily
H1I73_11775	COG1522	sequence-specific DNA binding
H1I73_11790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1I73_11800	COG4122	O-methyltransferase activity
H1I73_11830	COG1538	Outer membrane efflux protein
H1I73_11835	COG1137	ATPase activity
H1I73_11840	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H1I73_11850	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H1I73_11855	COG0517	IMP dehydrogenase activity
H1I73_11855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H1I73_11890	COG2814	Major facilitator Superfamily
H1I73_11925	COG1278	Cold shock
H1I73_11930	COG1280	lysine exporter protein (LysE YggA)
H1I73_11960	COG1570	exodeoxyribonuclease VII activity
H1I73_12010	COG0583	DNA-binding transcription factor activity
H1I73_12015	COG4638	Rieske (2fe-2S)
H1I73_12020	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I73_12025	COG0543	2 iron, 2 sulfur cluster binding
H1I73_12025	COG0633	Ferredoxin
H1I73_12030	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_12035	COG3135	benzoate transporter
H1I73_12040	COG2814	Major facilitator Superfamily
H1I73_12055	COG1643	Atp-dependent helicase
H1I73_12060	COG0450	alkyl hydroperoxide reductase
H1I73_12070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1I73_12100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H1I73_12105	COG0625	glutathione transferase activity
H1I73_12115	COG2885	chlorophyll binding
H1I73_12150	COG0542	response to heat
H1I73_12165	COG1765	OsmC-like protein
H1I73_12180	COG0667	Aldo Keto reductase
H1I73_12195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H1I73_12205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H1I73_12215	COG0527	aspartate kinase activity
H1I73_12225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H1I73_12235	COG3038	cytochrome b561
H1I73_12240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H1I73_12245	COG2252	PERMEase
H1I73_12255	COG2072	flavoprotein involved in K transport
H1I73_12270	COG1741	Belongs to the pirin family
H1I73_12275	COG1309	transcriptional regulator
H1I73_12295	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I73_12295	COG1902	pentaerythritol trinitrate reductase activity
H1I73_12305	COG4251	negative regulation of phosphorylation
H1I73_12305	COG2203	Gaf domain
H1I73_12305	COG3706	GGDEF domain
H1I73_12305	COG5001	Diguanylate cyclase
H1I73_12315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I73_12335	COG4172	Belongs to the ABC transporter superfamily
H1I73_12340	COG4239	(ABC) transporter, permease
H1I73_12345	COG4174	ABC transporter (Permease)
H1I73_12355	COG1388	LysM domain
H1I73_12355	COG0741	lytic transglycosylase activity
H1I73_12355	COG0741	lytic transglycosylase activity
H1I73_12355	COG1388	LysM domain
H1I73_12360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I73_12400	COG0583	DNA-binding transcription factor activity
H1I73_12405	COG1279	arginine transmembrane transporter activity
H1I73_12425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I73_12430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I73_12435	COG0006	proline dipeptidase activity
H1I73_12470	COG2194	sulfuric ester hydrolase activity
H1I73_12850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H1I73_12875	COG3384	dioxygenase
H1I73_12885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I73_12890	COG2878	Part of a membrane complex involved in electron transport
H1I73_12895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H1I73_12920	COG0768	penicillin binding
H1I73_12925	COG0742	ribosomal rna small subunit methyltransferase
H1I73_12940	COG0830	nickel cation binding
H1I73_12950	COG0804	urea catabolic process
H1I73_12990	COG1253	flavin adenine dinucleotide binding
H1I73_12995	COG2851	Citrate transporter
H1I73_13050	COG1773	rubredoxin
H1I73_13055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I73_13065	COG0583	DNA-binding transcription factor activity
H1I73_13090	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H1I73_13095	COG4181	ATPase activity
H1I73_13140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H1I73_13160	COG0306	phosphate transporter
H1I73_13170	COG3958	Transketolase
H1I73_13175	COG3959	Transketolase, thiamine diphosphate binding domain
H1I73_13180	COG2271	Major facilitator Superfamily
H1I73_13185	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_13190	COG0583	DNA-binding transcription factor activity
H1I73_13205	COG2223	nitrite transmembrane transporter activity
H1I73_13210	COG2207	Transcriptional regulator
H1I73_13215	COG2066	Belongs to the glutaminase family
H1I73_13220	COG0242	peptide deformylase activity
H1I73_13225	COG0477	Major facilitator Superfamily
H1I73_13235	COG0028	Belongs to the TPP enzyme family
H1I73_13250	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_13255	COG2267	carboxylic ester hydrolase activity
H1I73_13265	COG2271	Major facilitator Superfamily
H1I73_13270	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I73_13280	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_13300	COG1414	Transcriptional regulator
H1I73_13315	COG1024	Enoyl-CoA hydratase
H1I73_13325	COG1215	transferase activity, transferring glycosyl groups
H1I73_13330	COG1649	PFAM Uncharacterised BCR, COG1649
H1I73_13330	COG0726	polysaccharide deacetylase
H1I73_13340	COG4681	YaeQ
H1I73_13350	COG0523	cobalamin synthesis protein
H1I73_13360	COG1607	acyl-coa hydrolase
H1I73_13370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I73_13375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I73_13380	COG1309	transcriptional regulator
H1I73_13405	COG2040	homocysteine
H1I73_13410	COG0531	amino acid
H1I73_13465	COG1595	DNA-templated transcription, initiation
H1I73_13475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I73_13480	COG0477	Major facilitator Superfamily
H1I73_13500	COG0084	hydrolase, TatD family'
H1I73_13535	COG0629	single-stranded DNA binding
H1I73_13590	COG0582	viral genome integration into host DNA
H1I73_13685	COG0592	DNA-directed DNA polymerase activity
H1I73_13725	COG2026	Addiction module toxin, RelE StbE family
H1I73_13875	COG3755	Protein conserved in bacteria
H1I73_13920	COG1484	DNA-dependent DNA replication
H1I73_14010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I73_14080	COG0405	Gamma-glutamyltransferase
H1I73_14085	COG2814	Major facilitator Superfamily
H1I73_14095	COG2050	protein possibly involved in aromatic compounds catabolism
H1I73_14110	COG1090	epimerase
H1I73_14130	COG0420	3'-5' exonuclease activity
H1I73_14155	COG0735	belongs to the Fur family
H1I73_14160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1I73_14180	COG0121	glutamine amidotransferase
H1I73_14195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I73_14205	COG0210	DNA helicase
H1I73_14210	COG2885	chlorophyll binding
H1I73_14215	COG0204	Acyl-transferase
H1I73_14230	COG2894	cell division
H1I73_14250	COG1280	lysine exporter protein (LysE YggA)
H1I73_14255	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H1I73_14255	COG1674	ftsk spoiiie
H1I73_14260	COG0492	ferredoxin-NADP+ reductase activity
H1I73_14265	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H1I73_14275	COG0456	acetyltransferase
H1I73_14320	COG1981	membrane
H1I73_14335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I73_14335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H1I73_14355	COG1012	belongs to the aldehyde dehydrogenase family
H1I73_14365	COG0657	acetylesterase activity
H1I73_14375	COG0473	3-isopropylmalate dehydrogenase activity
H1I73_14400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I73_14425	COG0564	pseudouridine synthase activity
H1I73_14435	COG0358	DNA primase activity
H1I73_14450	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H1I73_14480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I73_14510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1I73_14520	COG0351	phosphomethylpyrimidine kinase
H1I73_14520	COG0352	thiamine-phosphate diphosphorylase activity
H1I73_14525	COG1652	LysM domain
H1I73_14550	COG1399	metal-binding, possibly nucleic acid-binding protein
H1I73_14555	COG3101	peptidyl-lysine hydroxylation
H1I73_14560	COG0009	L-threonylcarbamoyladenylate synthase
H1I73_14565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H1I73_14570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H1I73_14585	COG4106	trans-aconitate 2-methyltransferase activity
H1I73_14600	COG2226	methyltransferase
H1I73_14600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I73_14600	COG0596	Alpha beta hydrolase
H1I73_14605	COG1877	trehalose-phosphatase activity
H1I73_14610	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H1I73_14615	COG2223	nitrite transmembrane transporter activity
H1I73_14635	COG1196	nuclear chromosome segregation
H1I73_14645	COG0730	response to heat
H1I73_14660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H1I73_14670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I73_14720	COG0489	protein tyrosine kinase activity
H1I73_14730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I73_14730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I73_14760	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H1I73_14765	COG2081	HI0933 family
H1I73_14775	COG0668	transmembrane transport
H1I73_14795	COG0583	DNA-binding transcription factor activity
H1I73_14815	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1I73_14820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I73_14850	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H1I73_14890	COG0745	RESPONSE REGULATOR receiver
H1I73_14910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H1I73_14920	COG2205	protein histidine kinase activity
H1I73_14990	COG4993	Dehydrogenase
H1I73_15015	COG0384	phenazine biosynthesis protein PhzF
H1I73_15035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I73_15050	COG0583	DNA-binding transcription factor activity
H1I73_15080	COG0583	DNA-binding transcription factor activity
H1I73_15095	COG0583	DNA-binding transcription factor activity
H1I73_15100	COG1053	succinate dehydrogenase
H1I73_15110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H1I73_15115	COG2814	Major facilitator Superfamily
H1I73_15120	COG1960	acyl-CoA dehydrogenase activity
H1I73_15125	COG0583	DNA-binding transcription factor activity
H1I73_15130	COG1063	alcohol dehydrogenase
H1I73_15160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H1I73_15165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H1I73_15170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I73_15185	COG3667	copper resistance
H1I73_15190	COG2132	Multicopper oxidase
H1I73_15200	COG0561	phosphatase activity
H1I73_15205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H1I73_15230	COG1214	PFAM Peptidase M22, glycoprotease
H1I73_15285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1I73_15295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H1I73_15300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H1I73_15305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H1I73_15365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I73_15375	COG1846	Transcriptional regulator
H1I73_15380	COG1764	response to oxidative stress
H1I73_15430	COG0037	tRNA processing
H1I73_15440	COG0248	Ppx GppA phosphatase
H1I73_15470	COG0072	phenylalanine-tRNA ligase activity
H1I73_15510	COG1238	metal cluster binding
H1I73_15515	COG0625	glutathione transferase activity
H1I73_15530	COG0318	PFAM AMP-dependent synthetase and ligase
H1I73_15535	COG3028	Belongs to the UPF0307 family
H1I73_15540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I73_15560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H1I73_15565	COG0617	tRNA 3'-terminal CCA addition
H1I73_15570	COG1555	photosystem II stabilization
H1I73_15575	COG3956	TIGRFAM MazG family protein
H1I73_15585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I73_15605	COG0784	Response regulator, receiver
H1I73_15605	COG2205	protein histidine kinase activity
H1I73_15605	COG5002	protein histidine kinase activity
H1I73_15610	COG1024	Enoyl-CoA hydratase
H1I73_15615	COG2084	Dehydrogenase
H1I73_15620	COG3622	Belongs to the hyi family
H1I73_15650	COG0697	spore germination
H1I73_15660	COG2814	Major facilitator Superfamily
H1I73_15665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I73_15675	COG0583	DNA-binding transcription factor activity
H1I73_15685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H1I73_15700	COG0084	hydrolase, TatD family'
H1I73_15715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H1I73_15745	COG0440	acetolactate synthase activity
H1I73_15750	COG0028	Belongs to the TPP enzyme family
H1I73_15775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I73_15780	COG1136	(ABC) transporter
H1I73_15780	COG0577	efflux transmembrane transporter activity
H1I73_15785	COG1538	Outer membrane efflux protein
H1I73_15800	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H1I73_15805	COG1162	GTPase activity
H1I73_15815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1I73_15835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1I73_15840	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_15880	COG2986	histidine ammonia-lyase
H1I73_15895	COG0318	PFAM AMP-dependent synthetase and ligase
H1I73_15905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1I73_15950	COG1426	Protein conserved in bacteria
H1I73_15985	COG0793	Belongs to the peptidase S41A family
H1I73_16000	COG2267	carboxylic ester hydrolase activity
H1I73_16010	COG1012	belongs to the aldehyde dehydrogenase family
H1I73_16015	COG3265	gluconokinase activity
H1I73_16025	COG0800	Aldolase
H1I73_16040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H1I73_16045	COG0857	belongs to the CobB CobQ family
H1I73_16045	COG0280	phosphate acetyltransferase
H1I73_16050	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I73_16050	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I73_16070	COG0740	serine-type endopeptidase activity
H1I73_16080	COG4774	siderophore transport
H1I73_16090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1I73_16100	COG2813	Specifically methylates the guanine in position
H1I73_16100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I73_16200	COG0788	formyltetrahydrofolate deformylase activity
H1I73_16225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I73_16225	COG4651	solute:proton antiporter activity
H1I73_16245	COG0724	RNA recognition motif
H1I73_16250	COG0210	DNA helicase
H1I73_16275	COG1733	regulation of RNA biosynthetic process
H1I73_16285	COG2900	Belongs to the SlyX family
H1I73_16290	COG0488	(ABC) transporter
H1I73_16295	COG1280	lysine exporter protein (LysE YggA)
H1I73_16300	COG1560	Kdo2-lipid A biosynthetic process
H1I73_16310	COG1301	dicarboxylic acid transport
H1I73_16365	COG0473	3-isopropylmalate dehydrogenase activity
H1I73_16430	COG0583	DNA-binding transcription factor activity
H1I73_16440	COG0625	glutathione transferase activity
H1I73_16445	COG2378	regulation of single-species biofilm formation
H1I73_16450	COG0546	phosphoglycolate phosphatase activity
H1I73_16460	COG1530	ribonuclease E activity
H1I73_16465	COG0318	PFAM AMP-dependent synthetase and ligase
H1I73_16480	COG0583	DNA-binding transcription factor activity
H1I73_16485	COG4221	oxidoreductase activity
H1I73_16490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1I73_16500	COG0534	Mate efflux family protein
H1I73_16515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H1I73_16555	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H1I73_16560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I73_16575	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I73_16585	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H1I73_16585	COG0644	oxidoreductase
H1I73_16590	COG0425	Belongs to the sulfur carrier protein TusA family
H1I73_16595	COG4535	Mg2 and Co2 transporter CorC
H1I73_16605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I73_16625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H1I73_16630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I73_16630	COG0475	glutathione-regulated potassium exporter activity
H1I73_16635	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H1I73_16645	COG0484	heat shock protein binding
H1I73_16650	COG0789	Transcriptional regulator
H1I73_16655	COG0598	Magnesium transport protein CorA
H1I73_16670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I73_16675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I73_16680	COG1074	ATP-dependent DNA helicase activity
H1I73_16685	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H1I73_16705	COG2226	methyltransferase
H1I73_16720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I73_16725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H1I73_16740	COG2111	Na H antiporter
H1I73_16740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I73_16745	COG1006	Multisubunit Na H antiporter MnhC subunit
H1I73_16750	COG0651	ATP synthesis coupled electron transport
H1I73_16755	COG1863	multisubunit Na H antiporter MnhE subunit
H1I73_16760	COG2212	antiporter activity
H1I73_16765	COG1320	monovalent cation:proton antiporter activity
H1I73_16780	COG0195	Participates in both transcription termination and antitermination
H1I73_16830	COG0237	dephospho-CoA kinase activity
H1I73_16840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I73_16855	COG0497	DNA recombination
H1I73_16865	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H1I73_16895	COG2169	Transcriptional regulator
H1I73_16895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I73_16900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H1I73_16965	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H1I73_16980	COG0326	Molecular chaperone. Has ATPase activity
H1I73_16995	COG2056	Na+-H+ antiporter family
H1I73_17000	COG0596	Alpha beta hydrolase
H1I73_17095	COG0546	phosphoglycolate phosphatase activity
H1I73_17100	COG1716	ATPase activity
H1I73_17145	COG0181	hydroxymethylbilane synthase activity
H1I73_17155	COG3275	phosphorelay sensor kinase activity
H1I73_17175	COG1538	Outer membrane efflux protein
H1I73_17180	COG0697	spore germination
H1I73_17205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I73_17210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H1I73_17215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I73_17220	COG0772	Belongs to the SEDS family
H1I73_17245	COG4974	Belongs to the 'phage' integrase family
H1I73_17250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I73_17260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H1I73_17270	COG2197	response regulator
H1I73_17285	COG0793	Belongs to the peptidase S41A family
H1I73_17290	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H1I73_17295	COG0795	lipopolysaccharide-transporting ATPase activity
H1I73_17335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I73_17335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I73_17345	COG0004	ammonium transporteR
H1I73_17350	COG0347	Belongs to the P(II) protein family
H1I73_17360	COG0606	chelatase, subunit chli
H1I73_17430	COG1061	Type III restriction enzyme res subunit
H1I73_17445	COG0659	secondary active sulfate transmembrane transporter activity
H1I73_17450	COG0589	response to stress
H1I73_17480	COG0606	chelatase, subunit chli
H1I73_17495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I73_17510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H1I73_17525	COG0318	PFAM AMP-dependent synthetase and ligase
H1I73_17535	COG0477	Major facilitator Superfamily
H1I73_17540	COG2860	membrane
H1I73_17550	COG1253	flavin adenine dinucleotide binding
H1I73_17570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1I73_17605	COG0655	NAD(P)H dehydrogenase (quinone) activity
H1I73_17615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H1I73_17650	COG1309	transcriptional regulator
H1I73_17685	COG0758	DNA mediated transformation
H1I73_17695	COG0697	spore germination
H1I73_17700	COG1309	transcriptional regulator
H1I73_17715	COG0386	Belongs to the glutathione peroxidase family
H1I73_17780	COG1121	(ABC) transporter
H1I73_17785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1I73_17790	COG1280	lysine exporter protein (LysE YggA)
H1I73_17795	COG2837	iron assimilation
H1I73_17805	COG0281	malic enzyme
H1I73_17850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I73_17850	COG0519	Catalyzes the synthesis of GMP from XMP
H1I73_17855	COG4399	Belongs to the UPF0754 family
H1I73_17860	COG2259	Doxx family
H1I73_17880	COG1192	Involved in chromosome partitioning
H1I73_17890	COG0271	Belongs to the BolA IbaG family
H1I73_17910	COG2267	carboxylic ester hydrolase activity
H1I73_17930	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H1I73_17930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1I73_17930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H1I73_17930	COG3321	synthase
H1I73_17935	COG1960	acyl-CoA dehydrogenase activity
H1I73_17945	COG2197	response regulator
H1I73_17955	COG3916	Acyl-homoserine-lactone synthase
H1I73_17960	COG0477	Major facilitator Superfamily
H1I73_17965	COG1024	Enoyl-CoA hydratase
H1I73_17970	COG1024	Enoyl-CoA hydratase
H1I73_17975	COG1960	acyl-CoA dehydrogenase activity
H1I73_17980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I73_18000	COG1113	amino acid transport
H1I73_18005	COG1113	amino acid transport
H1I73_18010	COG0251	oxidation-reduction process
H1I73_18050	COG0564	pseudouridine synthase activity
H1I73_18110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H1I73_18125	COG1802	Transcriptional regulator
H1I73_18135	COG1448	Aminotransferase
H1I73_18140	COG0277	FAD linked oxidase domain protein
H1I73_18150	COG2186	Transcriptional regulator
H1I73_18160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I73_18165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I73_18180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H1I73_18185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1I73_18210	COG0438	transferase activity, transferring glycosyl groups
H1I73_18240	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H1I73_18270	COG0728	peptidoglycan biosynthetic process
H1I73_18275	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1I73_18330	COG0546	phosphoglycolate phosphatase activity
H1I73_18335	COG1028	Short-chain dehydrogenase reductase Sdr
H1I73_18355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I73_18360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I73_18365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I73_18370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I73_18375	COG1116	anion transmembrane transporter activity
H1I73_18380	COG1309	transcriptional regulator
H1I73_18385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1I73_18395	COG0196	riboflavin kinase activity
H1I73_18400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H1I73_18410	COG1047	Peptidyl-prolyl cis-trans
H1I73_18450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H1I73_18455	COG0657	acetylesterase activity
H1I73_18505	COG2951	lytic endotransglycosylase activity
H1I73_18510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H1I73_18525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H1I73_18535	COG0671	phosphoesterase, PA-phosphatase related
H1I73_18540	COG0861	Integral membrane protein TerC family
H1I73_18550	COG0754	glutathionylspermidine amidase activity
H1I73_18560	COG0402	S-adenosylhomocysteine deaminase activity
H1I73_18575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I73_18580	COG1230	cation diffusion facilitator family transporter
H1I73_18595	COG0706	membrane insertase activity