locus-tag	class	description
H1I66_00010	COG0592	DNA-directed DNA polymerase activity
H1I66_00020	COG0187	DNA topoisomerase II activity
H1I66_00030	COG0586	Pfam SNARE associated Golgi protein
H1I66_00035	COG0488	(ABC) transporter
H1I66_00060	COG0596	Alpha beta hydrolase
H1I66_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H1I66_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H1I66_00110	COG0733	neurotransmitter:sodium symporter activity
H1I66_00150	COG2233	PERMEase
H1I66_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I66_00200	COG2814	Major facilitator Superfamily
H1I66_00205	COG0656	L-ascorbic acid biosynthetic process
H1I66_00210	COG0583	DNA-binding transcription factor activity
H1I66_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I66_00230	COG1064	alcohol dehydrogenase
H1I66_00235	COG2818	Glycosylase
H1I66_00250	COG1194	a g-specific adenine glycosylase
H1I66_00270	COG2983	Belongs to the UPF0260 family
H1I66_00275	COG2133	pyrroloquinoline quinone binding
H1I66_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H1I66_00285	COG2116	formate transmembrane transporter activity
H1I66_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I66_00310	COG1335	isochorismatase
H1I66_00315	COG0385	Bile acid
H1I66_00320	COG0534	Mate efflux family protein
H1I66_00345	COG0625	glutathione transferase activity
H1I66_00355	COG1113	amino acid transport
H1I66_00365	COG0523	cobalamin synthesis protein
H1I66_00375	COG2188	Transcriptional regulator
H1I66_00405	COG0010	Belongs to the arginase family
H1I66_00425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I66_00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1I66_00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H1I66_00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H1I66_00545	COG0534	Mate efflux family protein
H1I66_00550	COG0436	Aminotransferase
H1I66_00555	COG2733	membrane
H1I66_00570	COG2918	glutathione biosynthetic process
H1I66_00590	COG1388	LysM domain
H1I66_00590	COG0791	NLP P60 protein
H1I66_00610	COG3150	esterase
H1I66_00620	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_00625	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H1I66_00635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I66_00645	COG2233	PERMEase
H1I66_00650	COG2351	hydroxyisourate hydrolase activity
H1I66_00685	COG3706	GGDEF domain
H1I66_00700	COG1393	Belongs to the ArsC family
H1I66_00705	COG0708	Exodeoxyribonuclease III
H1I66_00725	COG0189	ligase activity
H1I66_00745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H1I66_00755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1I66_00770	COG4942	peptidase
H1I66_00780	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I66_00790	COG2119	membrane
H1I66_00795	COG4774	siderophore transport
H1I66_00800	COG0426	domain, Protein
H1I66_00800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I66_00825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H1I66_00845	COG1902	pentaerythritol trinitrate reductase activity
H1I66_00850	COG1519	Transferase
H1I66_00855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I66_00860	COG0668	transmembrane transport
H1I66_00870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I66_00875	COG1335	isochorismatase
H1I66_00880	COG1522	sequence-specific DNA binding
H1I66_00885	COG3328	transposase activity
H1I66_00910	COG0784	Response regulator, receiver
H1I66_00910	COG2198	Histidine kinase
H1I66_00910	COG2205	protein histidine kinase activity
H1I66_00915	COG3162	membrane
H1I66_00920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I66_00930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I66_00950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H1I66_00955	COG1309	transcriptional regulator
H1I66_00975	COG0351	phosphomethylpyrimidine kinase
H1I66_00975	COG0352	thiamine-phosphate diphosphorylase activity
H1I66_00975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I66_00985	COG2814	Major facilitator Superfamily
H1I66_01020	COG1002	Type II restriction enzyme, methylase subunits
H1I66_01030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I66_01040	COG1061	Type III restriction enzyme res subunit
H1I66_01055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I66_01065	COG1113	amino acid transport
H1I66_01075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I66_01080	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_01090	COG1335	isochorismatase
H1I66_01120	COG2814	Major facilitator Superfamily
H1I66_01125	COG0583	DNA-binding transcription factor activity
H1I66_01145	COG0667	Aldo Keto reductase
H1I66_01175	COG1733	regulation of RNA biosynthetic process
H1I66_01180	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I66_01245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H1I66_01260	COG2329	Antibiotic biosynthesis monooxygenase
H1I66_01290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H1I66_01320	COG0427	acetyl-CoA hydrolase
H1I66_01345	COG0659	secondary active sulfate transmembrane transporter activity
H1I66_01350	COG4221	oxidoreductase activity
H1I66_01355	COG2873	o-acetylhomoserine
H1I66_01360	COG0488	(ABC) transporter
H1I66_01445	COG0833	amino acid
H1I66_01490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H1I66_01495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H1I66_01510	COG2226	methyltransferase
H1I66_01560	COG0067	glutamate synthase
H1I66_01560	COG0070	glutamate synthase
H1I66_01560	COG0069	glutamate synthase activity
H1I66_01565	COG0493	'glutamate synthase
H1I66_01575	COG1704	LemA family
H1I66_01580	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H1I66_01595	COG4969	Belongs to the N-Me-Phe pilin family
H1I66_01600	COG3307	-O-antigen
H1I66_01620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I66_01635	COG0194	GDP metabolic process
H1I66_01685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H1I66_01705	COG5380	lipid catabolic process
H1I66_01710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H1I66_01735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1I66_01740	COG0277	FAD linked oxidase domain protein
H1I66_01750	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H1I66_01755	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I66_01770	COG1289	transmembrane transporter activity
H1I66_01780	COG0628	permease
H1I66_01785	COG1192	Involved in chromosome partitioning
H1I66_01815	COG0833	amino acid
H1I66_01820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I66_01825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I66_01835	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_01875	COG0583	DNA-binding transcription factor activity
H1I66_01920	COG0517	IMP dehydrogenase activity
H1I66_01925	COG1983	PspC domain protein
H1I66_01935	COG1960	acyl-CoA dehydrogenase activity
H1I66_01950	COG0408	coproporphyrinogen oxidase activity
H1I66_01970	COG0513	Belongs to the DEAD box helicase family
H1I66_01980	COG1127	ABC transporter
H1I66_01985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H1I66_01995	COG2854	intermembrane phospholipid transfer
H1I66_02005	COG0598	Magnesium transport protein CorA
H1I66_02015	COG0494	nUDIX hydrolase
H1I66_02020	COG1040	competence protein
H1I66_02025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H1I66_02050	COG1301	dicarboxylic acid transport
H1I66_02065	COG1959	2 iron, 2 sulfur cluster binding
H1I66_02070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I66_02070	COG1017	nitric oxide dioxygenase activity
H1I66_02075	COG0433	COG0433 Predicted ATPase
H1I66_02080	COG0626	cystathionine gamma-synthase activity
H1I66_02235	COG1960	acyl-CoA dehydrogenase activity
H1I66_02240	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H1I66_02270	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H1I66_02275	COG0339	signal peptide processing
H1I66_02280	COG0557	exoribonuclease II activity
H1I66_02325	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1I66_02330	COG2169	Transcriptional regulator
H1I66_02335	COG0697	spore germination
H1I66_02340	COG1295	ribonuclease BN
H1I66_02375	COG1702	phosphate starvation-inducible protein PhoH
H1I66_02385	COG0741	lytic transglycosylase activity
H1I66_02385	COG0739	heme binding
H1I66_02385	COG1196	nuclear chromosome segregation
H1I66_02415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H1I66_02420	COG1183	phosphatidylcholine synthase activity
H1I66_02465	COG1960	acyl-CoA dehydrogenase activity
H1I66_02470	COG1309	transcriptional regulator
H1I66_02485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I66_02490	COG1960	acyl-CoA dehydrogenase activity
H1I66_02510	COG2969	positive regulation of protein catabolic process
H1I66_02520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H1I66_02535	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1I66_02540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H1I66_02560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1I66_02570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I66_02575	COG1408	metallophosphoesterase
H1I66_02585	COG2199	diguanylate cyclase activity
H1I66_02645	COG1607	acyl-coa hydrolase
H1I66_02675	COG2350	Protein conserved in bacteria
H1I66_02685	COG0613	PHP domain protein
H1I66_02690	COG3781	membrane
H1I66_02700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H1I66_02705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H1I66_02715	COG1862	Preprotein translocase
H1I66_02760	COG2205	protein histidine kinase activity
H1I66_02765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H1I66_02785	COG0726	polysaccharide deacetylase
H1I66_02790	COG0463	Glycosyl transferase, family 2
H1I66_02795	COG0438	transferase activity, transferring glycosyl groups
H1I66_02860	COG0625	glutathione transferase activity
H1I66_02865	COG0583	DNA-binding transcription factor activity
H1I66_02870	COG1960	acyl-CoA dehydrogenase activity
H1I66_02875	COG1960	acyl-CoA dehydrogenase activity
H1I66_02885	COG2205	protein histidine kinase activity
H1I66_02890	COG0745	RESPONSE REGULATOR receiver
H1I66_02895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H1I66_02915	COG2096	Adenosyltransferase
H1I66_02965	COG0285	dihydrofolate synthase activity
H1I66_02985	COG0450	alkyl hydroperoxide reductase
H1I66_03000	COG0477	Major facilitator Superfamily
H1I66_03005	COG1272	protein, Hemolysin III
H1I66_03035	COG0183	Belongs to the thiolase family
H1I66_03040	COG2207	Transcriptional regulator
H1I66_03060	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I66_03080	COG0183	Belongs to the thiolase family
H1I66_03090	COG2885	chlorophyll binding
H1I66_03090	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H1I66_03100	COG1690	Belongs to the RtcB family
H1I66_03105	COG0833	amino acid
H1I66_03115	COG2233	PERMEase
H1I66_03120	COG1217	gtp-binding protein TYPA
H1I66_03145	COG2094	Belongs to the DNA glycosylase MPG family
H1I66_03150	COG4772	TonB-dependent receptor
H1I66_03165	COG1902	pentaerythritol trinitrate reductase activity
H1I66_03170	COG0679	Auxin Efflux Carrier
H1I66_03180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I66_03185	COG0354	folic acid binding
H1I66_03195	COG3189	MarR family transcriptional regulator
H1I66_03200	COG2824	Alkylphosphonate utilization operon protein PhnA
H1I66_03205	COG3422	double-strand break repair
H1I66_03245	COG0840	transmembrane signaling receptor activity
H1I66_03265	COG5510	response to toxic substance
H1I66_03275	COG2832	Protein of unknown function (DUF454)
H1I66_03280	COG1376	ErfK ybiS ycfS ynhG family protein
H1I66_03320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H1I66_03330	COG1289	transmembrane transporter activity
H1I66_03335	COG2814	Major facilitator Superfamily
H1I66_03355	COG1115	amino acid carrier protein
H1I66_03360	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I66_03365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I66_03370	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H1I66_03400	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I66_03410	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I66_03415	COG1077	Cell shape determining protein MreB Mrl
H1I66_03420	COG1792	Involved in formation and maintenance of cell shape
H1I66_03425	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H1I66_03430	COG0424	maF-like protein
H1I66_03435	COG1530	ribonuclease E activity
H1I66_03445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I66_03455	COG0560	Phosphoserine phosphatase
H1I66_03465	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I66_03490	COG2207	Transcriptional regulator
H1I66_03510	COG1113	amino acid transport
H1I66_03515	COG2828	Protein conserved in bacteria
H1I66_03520	COG0142	geranyltranstransferase activity
H1I66_03525	COG2315	Protein conserved in bacteria
H1I66_03540	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I66_03560	COG2194	sulfuric ester hydrolase activity
H1I66_03565	COG0745	RESPONSE REGULATOR receiver
H1I66_03570	COG0642	Histidine kinase
H1I66_03580	COG0004	ammonium transporteR
H1I66_03585	COG0583	DNA-binding transcription factor activity
H1I66_03605	COG0525	valine-tRNA ligase activity
H1I66_03615	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_03625	COG0393	Putative heavy-metal-binding
H1I66_03630	COG0393	Putative heavy-metal-binding
H1I66_03635	COG1538	Outer membrane efflux protein
H1I66_03645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I66_03650	COG0671	phosphoesterase, PA-phosphatase related
H1I66_03680	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H1I66_03695	COG1648	precorrin-2 dehydrogenase activity
H1I66_03695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H1I66_03700	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H1I66_03705	COG1733	regulation of RNA biosynthetic process
H1I66_03715	COG0531	amino acid
H1I66_03735	COG0321	lipoyl(octanoyl) transferase activity
H1I66_03740	COG2921	Belongs to the UPF0250 family
H1I66_03780	COG2009	succinate dehydrogenase
H1I66_03785	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H1I66_03790	COG1053	succinate dehydrogenase
H1I66_03795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H1I66_03820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I66_03840	COG2354	Protein conserved in bacteria
H1I66_03845	COG2321	neutral zinc metallopeptidase
H1I66_03880	COG2843	Capsule synthesis protein
H1I66_03895	COG0589	response to stress
H1I66_03915	COG0505	Belongs to the CarA family
H1I66_03940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I66_03945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H1I66_03995	COG0477	Major facilitator Superfamily
H1I66_04000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H1I66_04015	COG1597	lipid kinase activity
H1I66_04020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I66_04050	COG0584	glycerophosphoryl diester phosphodiesterase
H1I66_04070	COG0741	lytic transglycosylase activity
H1I66_04090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1I66_04105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I66_04130	COG0778	Nitroreductase
H1I66_04145	COG1929	Belongs to the glycerate kinase type-1 family
H1I66_04150	COG0243	molybdopterin cofactor binding
H1I66_04155	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H1I66_04160	COG3339	Conserved Protein
H1I66_04170	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H1I66_04185	COG1113	amino acid transport
H1I66_04195	COG0019	diaminopimelate decarboxylase activity
H1I66_04205	COG1280	lysine exporter protein (LysE YggA)
H1I66_04210	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H1I66_04240	COG0463	Glycosyl transferase, family 2
H1I66_04260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I66_04295	COG4591	ABC-type transport system involved in lipoprotein release permease component
H1I66_04300	COG1136	(ABC) transporter
H1I66_04305	COG0658	competence protein
H1I66_04305	COG2333	competence protein COMEC
H1I66_04315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H1I66_04315	COG0616	signal peptide processing
H1I66_04320	COG0596	Alpha beta hydrolase
H1I66_04325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H1I66_04335	COG0628	permease
H1I66_04370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I66_04390	COG0823	Involved in the tonB-independent uptake of proteins
H1I66_04410	COG0824	Thioesterase
H1I66_04415	COG1473	amidohydrolase
H1I66_04435	COG0047	phosphoribosylformylglycinamidine synthase activity
H1I66_04435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1I66_04440	COG2814	Major facilitator Superfamily
H1I66_04450	COG1024	Enoyl-CoA hydratase
H1I66_04455	COG1051	belongs to the nudix hydrolase family
H1I66_04455	COG1056	cytidyltransferase-related domain
H1I66_04465	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H1I66_04480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H1I66_04495	COG4625	pathogenesis
H1I66_04500	COG0583	DNA-binding transcription factor activity
H1I66_04505	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1I66_04510	COG4208	sulfate ABC transporter
H1I66_04515	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H1I66_04530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1I66_04535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H1I66_04555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I66_04570	COG0681	Belongs to the peptidase S26 family
H1I66_04585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H1I66_04595	COG1381	Involved in DNA repair and RecF pathway recombination
H1I66_04600	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H1I66_04610	COG4221	oxidoreductase activity
H1I66_04640	COG0436	Aminotransferase
H1I66_04660	COG0556	nucleotide-excision repair
H1I66_04715	COG2070	2-Nitropropane dioxygenase
H1I66_04745	COG1215	transferase activity, transferring glycosyl groups
H1I66_04760	COG0415	Belongs to the DNA photolyase family
H1I66_04770	COG1252	NADH dehydrogenase
H1I66_04775	COG1686	Belongs to the peptidase S11 family
H1I66_04790	COG1187	pseudouridine synthase activity
H1I66_04815	COG0477	Major facilitator Superfamily
H1I66_04820	COG0583	DNA-binding transcription factor activity
H1I66_04825	COG1823	symporter activity
H1I66_04835	COG0612	Peptidase, M16
H1I66_04860	COG0352	thiamine-phosphate diphosphorylase activity
H1I66_04895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I66_04910	COG1309	transcriptional regulator
H1I66_04920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I66_04925	COG0076	glutamate decarboxylase activity
H1I66_04935	COG1522	sequence-specific DNA binding
H1I66_04940	COG3961	Belongs to the TPP enzyme family
H1I66_04945	COG1113	amino acid transport
H1I66_04950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I66_04955	COG0573	inorganic phosphate transmembrane transporter activity
H1I66_04965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1I66_04970	COG0616	signal peptide processing
H1I66_04980	COG3328	transposase activity
H1I66_05010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H1I66_05015	COG1686	Belongs to the peptidase S11 family
H1I66_05040	COG0583	DNA-binding transcription factor activity
H1I66_05045	COG1067	ATP-dependent peptidase activity
H1I66_05090	COG1966	Carbon starvation protein
H1I66_05095	COG2879	small protein
H1I66_05125	COG2508	Transcriptional regulator
H1I66_05125	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H1I66_05145	COG1113	amino acid transport
H1I66_05150	COG0583	DNA-binding transcription factor activity
H1I66_05155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I66_05160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I66_05170	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_05175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I66_05180	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H1I66_05180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I66_05215	COG2814	Major facilitator Superfamily
H1I66_05220	COG4948	Mandelate Racemase Muconate Lactonizing
H1I66_05230	COG1309	transcriptional regulator
H1I66_05250	COG1741	Belongs to the pirin family
H1I66_05260	COG2964	Protein conserved in bacteria
H1I66_05275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I66_05280	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I66_05285	COG4605	iron ion homeostasis
H1I66_05290	COG4604	ABC transporter, ATP-binding protein
H1I66_05295	COG4607	ABC-type enterochelin transport system periplasmic component
H1I66_05300	COG4774	siderophore transport
H1I66_05310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I66_05315	COG1021	2,3-dihydroxybenzoate-AMP ligase
H1I66_05320	COG3433	isochorismatase activity
H1I66_05320	COG1535	isochorismatase
H1I66_05335	COG1132	(ABC) transporter
H1I66_05340	COG1132	(ABC) transporter
H1I66_05345	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H1I66_05355	COG1169	isochorismate synthase
H1I66_05370	COG3739	integral membrane protein
H1I66_05395	COG0302	gtp cyclohydrolase
H1I66_05405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1I66_05435	COG0308	aminopeptidase N
H1I66_05440	COG0512	Glutamine amidotransferase of anthranilate synthase
H1I66_05455	COG0174	glutamine synthetase
H1I66_05465	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H1I66_05500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H1I66_05505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H1I66_05510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I66_05530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I66_05535	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H1I66_05540	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H1I66_05555	COG1960	acyl-CoA dehydrogenase activity
H1I66_05560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I66_05565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I66_05575	COG2223	nitrite transmembrane transporter activity
H1I66_05585	COG0024	Methionine aminopeptidase
H1I66_05590	COG0052	Belongs to the universal ribosomal protein uS2 family
H1I66_05605	COG2207	Transcriptional regulator
H1I66_05630	COG2951	lytic endotransglycosylase activity
H1I66_05635	COG0772	Belongs to the SEDS family
H1I66_05650	COG0842	Transport permease protein
H1I66_05655	COG1131	(ABC) transporter
H1I66_05700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I66_05715	COG4215	(ABC) transporter
H1I66_05720	COG4160	amino acid transport
H1I66_05725	COG4598	ABC transporter
H1I66_05735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I66_05740	COG0826	peptidase U32
H1I66_05745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I66_05760	COG1720	tRNA m6t6A37 methyltransferase activity
H1I66_05770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H1I66_05785	COG0642	Histidine kinase
H1I66_05795	COG0494	nUDIX hydrolase
H1I66_05805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1I66_05810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H1I66_05815	COG3139	Protein of unknown function (DUF1315)
H1I66_05820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1I66_05825	COG1301	dicarboxylic acid transport
H1I66_05830	COG1960	acyl-CoA dehydrogenase activity
H1I66_05835	COG2819	hydrolase of the alpha beta superfamily
H1I66_05845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H1I66_05855	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1I66_05860	COG1234	tRNA 3'-trailer cleavage
H1I66_05890	COG2363	Small membrane protein
H1I66_05910	COG0513	Belongs to the DEAD box helicase family
H1I66_05920	COG0778	Nitroreductase
H1I66_05950	COG1286	toxin biosynthetic process
H1I66_05975	COG4783	chaperone-mediated protein folding
H1I66_05980	COG1610	YqeY-like protein
H1I66_06080	COG3111	PFAM Bacterial OB fold (BOF) protein
H1I66_06105	COG3243	poly(R)-hydroxyalkanoic acid synthase
H1I66_06110	COG0786	glutamate:sodium symporter activity
H1I66_06120	COG2186	Transcriptional regulator
H1I66_06170	COG0477	Major facilitator Superfamily
H1I66_06195	COG2985	domain, Protein
H1I66_06205	COG2995	paraquat-inducible protein a
H1I66_06210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H1I66_06210	COG3008	intermembrane lipid transfer
H1I66_06230	COG0482	sulfurtransferase activity
H1I66_06245	COG0488	(ABC) transporter
H1I66_06250	COG3173	Aminoglycoside phosphotransferase
H1I66_06260	COG2433	Pfam Transposase IS66
H1I66_06390	COG0590	tRNA wobble adenosine to inosine editing
H1I66_06395	COG2807	transmembrane transport
H1I66_06410	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H1I66_06425	COG0789	Transcriptional regulator
H1I66_06435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I66_06455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I66_06465	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I66_06480	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_06485	COG0531	amino acid
H1I66_06490	COG1760	l-serine dehydratase
H1I66_06495	COG2030	dehydratase
H1I66_06495	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_06500	COG3396	Phenylacetate-CoA oxygenase
H1I66_06505	COG3460	Phenylacetate-CoA oxygenase
H1I66_06510	COG3396	Phenylacetate-CoA oxygenase
H1I66_06515	COG2151	metal-sulfur cluster biosynthetic enzyme
H1I66_06520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I66_06525	COG1024	Enoyl-CoA hydratase
H1I66_06530	COG1024	Enoyl-CoA hydratase
H1I66_06535	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I66_06540	COG0183	Belongs to the thiolase family
H1I66_06545	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H1I66_06550	COG3327	negative regulation of DNA-templated transcription, initiation
H1I66_06560	COG2050	protein possibly involved in aromatic compounds catabolism
H1I66_06595	COG0753	catalase activity
H1I66_06600	COG3038	cytochrome b561
H1I66_06620	COG2267	carboxylic ester hydrolase activity
H1I66_06625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I66_06630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I66_06635	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_06645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I66_06655	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_06660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I66_06665	COG0583	DNA-binding transcription factor activity
H1I66_06675	COG1414	Transcriptional regulator
H1I66_06680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I66_06690	COG1840	ABC-type Fe3 transport system, periplasmic component
H1I66_06695	COG3842	ATPase activity
H1I66_06710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H1I66_06715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I66_06720	COG2814	Major facilitator Superfamily
H1I66_06725	COG1960	acyl-CoA dehydrogenase activity
H1I66_06740	COG1024	Enoyl-CoA hydratase
H1I66_06750	COG2814	Major facilitator Superfamily
H1I66_06760	COG0183	Belongs to the thiolase family
H1I66_06765	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I66_06770	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_06775	COG1024	Enoyl-CoA hydratase
H1I66_06780	COG1960	acyl-CoA dehydrogenase activity
H1I66_06785	COG2814	Major facilitator Superfamily
H1I66_06790	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I66_06795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I66_06805	COG2814	Major facilitator Superfamily
H1I66_06815	COG1960	acyl-CoA dehydrogenase activity
H1I66_06830	COG0583	DNA-binding transcription factor activity
H1I66_06840	COG4770	biotin carboxylase activity
H1I66_06845	COG1024	Enoyl-CoA hydratase
H1I66_06850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I66_06855	COG1960	acyl-CoA dehydrogenase activity
H1I66_06860	COG1309	transcriptional regulator
H1I66_06865	COG0318	PFAM AMP-dependent synthetase and ligase
H1I66_06885	COG0583	DNA-binding transcription factor activity
H1I66_06935	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_06955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1I66_06995	COG0765	amino acid transport
H1I66_07000	COG0765	amino acid transport
H1I66_07005	COG1126	abc transporter atp-binding protein
H1I66_07010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I66_07015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I66_07030	COG1280	lysine exporter protein (LysE YggA)
H1I66_07040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H1I66_07045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I66_07050	COG1045	serine acetyltransferase
H1I66_07065	COG0583	DNA-binding transcription factor activity
H1I66_07070	COG0625	glutathione transferase activity
H1I66_07075	COG0625	glutathione transferase activity
H1I66_07080	COG0583	DNA-binding transcription factor activity
H1I66_07090	COG1346	cytolysis
H1I66_07110	COG2814	Major facilitator Superfamily
H1I66_07120	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H1I66_07125	COG3052	prosthetic group binding
H1I66_07145	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1I66_07165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I66_07175	COG1294	oxidase, subunit
H1I66_07180	COG1271	oxidase subunit
H1I66_07205	COG0477	Major facilitator Superfamily
H1I66_07215	COG4521	taurine ABC transporter
H1I66_07220	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H1I66_07225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I66_07230	COG2175	clavaminate synthase activity
H1I66_07240	COG1953	Uracil, thiamine, allantoin
H1I66_07250	COG0583	DNA-binding transcription factor activity
H1I66_07260	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H1I66_07275	COG0640	Transcriptional regulator
H1I66_07280	COG0798	PFAM Bile acid sodium symporter
H1I66_07285	COG0583	DNA-binding transcription factor activity
H1I66_07300	COG3634	alkyl hydroperoxide reductase activity
H1I66_07340	COG0436	Aminotransferase
H1I66_07350	COG0386	Belongs to the glutathione peroxidase family
H1I66_07390	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I66_07415	COG0012	GTP binding
H1I66_07420	COG2011	ABC-type metal ion transport system permease component
H1I66_07425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I66_07435	COG1464	Belongs to the NlpA lipoprotein family
H1I66_07465	COG0765	amino acid transport
H1I66_07470	COG0765	amino acid transport
H1I66_07475	COG1126	abc transporter atp-binding protein
H1I66_07485	COG1522	sequence-specific DNA binding
H1I66_07500	COG1309	transcriptional regulator
H1I66_07520	COG0583	DNA-binding transcription factor activity
H1I66_07530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I66_07540	COG0697	spore germination
H1I66_07565	COG3121	Chaperone
H1I66_07570	COG3539	Fimbrial protein
H1I66_07595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H1I66_07595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H1I66_07640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H1I66_07650	COG2353	YceI-like domain
H1I66_07660	COG3698	Phosphodiester glycosidase
H1I66_07675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H1I66_07680	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I66_07680	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I66_07680	COG0506	proline dehydrogenase activity
H1I66_07690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I66_07695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H1I66_07715	COG1132	(ABC) transporter
H1I66_07720	COG3122	Protein conserved in bacteria
H1I66_07725	COG3619	membrane
H1I66_07740	COG0640	Transcriptional regulator
H1I66_07750	COG2850	peptidyl-arginine hydroxylation
H1I66_07755	COG0424	maF-like protein
H1I66_07775	COG0191	fructose-bisphosphate aldolase activity
H1I66_07780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I66_07795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1I66_07805	COG1192	Involved in chromosome partitioning
H1I66_07810	COG1475	DNA binding
H1I66_07815	COG0811	peptide transport
H1I66_07825	COG1132	(ABC) transporter
H1I66_07830	COG1663	tetraacyldisaccharide 4'-kinase activity
H1I66_07850	COG0084	hydrolase, TatD family'
H1I66_07915	COG0776	regulation of translation
H1I66_07945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H1I66_07950	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H1I66_08000	COG0339	signal peptide processing
H1I66_08010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1I66_08045	COG0702	epimerase
H1I66_08050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I66_08070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H1I66_08100	COG0316	Belongs to the HesB IscA family
H1I66_08105	COG0822	iron-sulfur transferase activity
H1I66_08130	COG0776	regulation of translation
H1I66_08135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I66_08140	COG2207	Transcriptional regulator
H1I66_08145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I66_08150	COG1960	acyl-CoA dehydrogenase activity
H1I66_08155	COG1960	acyl-CoA dehydrogenase activity
H1I66_08170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1I66_08190	COG4264	IucA IucC family
H1I66_08195	COG4264	IucA IucC family
H1I66_08235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I66_08250	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H1I66_08270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H1I66_08275	COG0730	response to heat
H1I66_08295	COG4773	Receptor
H1I66_08300	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I66_08315	COG1131	(ABC) transporter
H1I66_08320	COG0842	Transport permease protein
H1I66_08325	COG0842	Transport permease protein
H1I66_08380	COG2226	methyltransferase
H1I66_08405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H1I66_08440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I66_08450	COG0133	tryptophan synthase activity
H1I66_08465	COG3706	GGDEF domain
H1I66_08480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I66_08485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H1I66_08490	COG0022	dehydrogenase e1 component
H1I66_08495	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I66_08500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I66_08510	COG1063	alcohol dehydrogenase
H1I66_08515	COG3781	membrane
H1I66_08525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I66_08525	COG3453	Protein conserved in bacteria
H1I66_08535	COG0730	response to heat
H1I66_08555	COG2207	Transcriptional regulator
H1I66_08555	COG3708	Transcriptional regulator
H1I66_08560	COG1733	regulation of RNA biosynthetic process
H1I66_08565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H1I66_08575	COG2188	Transcriptional regulator
H1I66_08590	COG4521	taurine ABC transporter
H1I66_08595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I66_08615	COG0477	Major facilitator Superfamily
H1I66_08625	COG1027	Aspartate ammonia-lyase
H1I66_08640	COG0583	DNA-binding transcription factor activity
H1I66_08645	COG0583	DNA-binding transcription factor activity
H1I66_08650	COG0183	Belongs to the thiolase family
H1I66_08655	COG2031	fatty acid transporter
H1I66_08660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I66_08670	COG0583	DNA-binding transcription factor activity
H1I66_08680	COG2610	gluconate transmembrane transporter activity
H1I66_08685	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_08695	COG2207	Transcriptional regulator
H1I66_08710	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_08735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I66_08735	COG0543	2 iron, 2 sulfur cluster binding
H1I66_08740	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I66_08745	COG4638	Rieske (2fe-2S)
H1I66_08755	COG0725	ABC transporter, periplasmic molybdate-binding protein
H1I66_08760	COG4149	molybdate abc transporter
H1I66_08765	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H1I66_08770	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_08775	COG1535	isochorismatase
H1I66_08775	COG3433	isochorismatase activity
H1I66_08840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I66_08855	COG0753	catalase activity
H1I66_08865	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H1I66_08895	COG3539	Fimbrial protein
H1I66_08915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I66_08935	COG2072	flavoprotein involved in K transport
H1I66_08945	COG1538	Outer membrane efflux protein
H1I66_08950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I66_08955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I66_08960	COG0745	RESPONSE REGULATOR receiver
H1I66_08965	COG2205	protein histidine kinase activity
H1I66_08975	COG2207	Transcriptional regulator
H1I66_08990	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_09040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H1I66_09155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I66_09175	COG1120	ATPase activity
H1I66_09180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I66_09190	COG1064	alcohol dehydrogenase
H1I66_09205	COG2207	Transcriptional regulator
H1I66_09210	COG2084	Dehydrogenase
H1I66_09220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1I66_09225	COG0583	DNA-binding transcription factor activity
H1I66_09235	COG0129	dihydroxy-acid dehydratase activity
H1I66_09240	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_09255	COG1566	PFAM secretion protein HlyD family protein
H1I66_09275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I66_09305	COG0583	DNA-binding transcription factor activity
H1I66_09320	COG2188	Transcriptional regulator
H1I66_09350	COG3210	domain, Protein
H1I66_09355	COG2831	hemolysin activation secretion protein
H1I66_09370	COG1473	amidohydrolase
H1I66_09390	COG0583	DNA-binding transcription factor activity
H1I66_09395	COG1335	isochorismatase
H1I66_09405	COG1309	transcriptional regulator
H1I66_09435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H1I66_09445	COG1902	pentaerythritol trinitrate reductase activity
H1I66_09445	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I66_09450	COG1846	Transcriptional regulator
H1I66_09470	COG0753	catalase activity
H1I66_09485	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_09500	COG3162	membrane
H1I66_09510	COG3829	transcription factor binding
H1I66_09515	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_09520	COG1960	acyl-CoA dehydrogenase activity
H1I66_09540	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_09560	COG2186	Transcriptional regulator
H1I66_09570	COG0583	DNA-binding transcription factor activity
H1I66_09575	COG4948	Mandelate Racemase Muconate Lactonizing
H1I66_09580	COG4829	muconolactone delta-isomerase
H1I66_09590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I66_09595	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I66_09600	COG0183	Belongs to the thiolase family
H1I66_09605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I66_09615	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_09625	COG3733	amine oxidase
H1I66_09635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I66_09645	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_09655	COG4638	Rieske (2fe-2S)
H1I66_09675	COG0154	amidase activity
H1I66_09685	COG2814	Major facilitator Superfamily
H1I66_09710	COG1960	acyl-CoA dehydrogenase activity
H1I66_09715	COG0583	DNA-binding transcription factor activity
H1I66_09720	COG1414	Transcriptional regulator
H1I66_09735	COG2391	methyltransferase activity
H1I66_09745	COG4993	Dehydrogenase
H1I66_09750	COG3659	wide pore channel activity
H1I66_09755	COG3420	alginic acid biosynthetic process
H1I66_09760	COG0710	3-dehydroquinate dehydratase activity
H1I66_09765	COG3485	protocatechuate 3,4-dioxygenase
H1I66_09770	COG3485	protocatechuate 3,4-dioxygenase
H1I66_09775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I66_09780	COG2271	Major facilitator Superfamily
H1I66_09785	COG0596	Alpha beta hydrolase
H1I66_09790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H1I66_09795	COG0183	Belongs to the thiolase family
H1I66_09800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I66_09805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I66_09815	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H1I66_09820	COG2323	membrane
H1I66_09865	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I66_09865	COG1902	pentaerythritol trinitrate reductase activity
H1I66_09890	COG0542	response to heat
H1I66_09895	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1I66_09925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I66_09930	COG0569	domain protein
H1I66_09935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H1I66_09950	COG4774	siderophore transport
H1I66_09955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1I66_09965	COG1585	Membrane protein implicated in regulation of membrane protease activity
H1I66_09980	COG1294	oxidase, subunit
H1I66_09985	COG4890	Cyd operon protein YbgT
H1I66_10000	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H1I66_10010	COG0552	protein localization to endoplasmic reticulum
H1I66_10035	COG0516	GMP reductase activity
H1I66_10035	COG0517	IMP dehydrogenase activity
H1I66_10040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I66_10045	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H1I66_10055	COG0583	DNA-binding transcription factor activity
H1I66_10060	COG0024	Methionine aminopeptidase
H1I66_10090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I66_10090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1I66_10095	COG1105	Belongs to the carbohydrate kinase PfkB family
H1I66_10100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I66_10100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I66_10100	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H1I66_10120	COG3300	MHYT domain
H1I66_10120	COG5001	Diguanylate cyclase
H1I66_10135	COG2135	peptidase activity
H1I66_10140	COG0659	secondary active sulfate transmembrane transporter activity
H1I66_10155	COG1113	amino acid transport
H1I66_10165	COG1522	sequence-specific DNA binding
H1I66_10190	COG1011	Hydrolase
H1I66_10195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H1I66_10205	COG2137	regulation of response to DNA damage stimulus
H1I66_10220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I66_10255	COG0575	Belongs to the CDS family
H1I66_10260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H1I66_10280	COG3852	Histidine kinase
H1I66_10285	COG2204	response regulator
H1I66_10340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I66_10345	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H1I66_10365	COG0697	spore germination
H1I66_10370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I66_10380	COG0303	'Molybdopterin
H1I66_10385	COG0315	cyclic pyranopterin monophosphate synthase activity
H1I66_10385	COG0521	Mo-molybdopterin cofactor biosynthetic process
H1I66_10400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H1I66_10405	COG0243	molybdopterin cofactor binding
H1I66_10415	COG0243	molybdopterin cofactor binding
H1I66_10420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I66_10425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I66_10425	COG2146	nitrite reductase [NAD(P)H] activity
H1I66_10435	COG0745	RESPONSE REGULATOR receiver
H1I66_10440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I66_10440	COG1116	anion transmembrane transporter activity
H1I66_10460	COG0511	ligase activity, forming carbon-carbon bonds
H1I66_10475	COG2814	Major facilitator Superfamily
H1I66_10680	COG5410	chromosome segregation
H1I66_10870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H1I66_10880	COG1454	alcohol dehydrogenase
H1I66_10885	COG0824	Thioesterase
H1I66_10895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H1I66_10910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I66_10915	COG2030	dehydratase
H1I66_10925	COG0183	Belongs to the thiolase family
H1I66_10935	COG0583	DNA-binding transcription factor activity
H1I66_10940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H1I66_10950	COG1522	sequence-specific DNA binding
H1I66_10955	COG3135	benzoate transporter
H1I66_10965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H1I66_10990	COG0589	response to stress
H1I66_10995	COG0488	(ABC) transporter
H1I66_11015	COG4773	Receptor
H1I66_11050	COG0668	transmembrane transport
H1I66_11060	COG1309	transcriptional regulator
H1I66_11075	COG1605	Chorismate mutase
H1I66_11105	COG0308	aminopeptidase N
H1I66_11125	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H1I66_11135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I66_11140	COG1454	alcohol dehydrogenase
H1I66_11160	COG0531	amino acid
H1I66_11165	COG4303	Ethanolamine ammonia lyase large subunit
H1I66_11170	COG4302	ethanolamine ammonia-lyase activity
H1I66_11175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I66_11175	COG0519	Catalyzes the synthesis of GMP from XMP
H1I66_11180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I66_11190	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I66_11205	COG0697	spore germination
H1I66_11210	COG1923	regulation of RNA biosynthetic process
H1I66_11220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H1I66_11225	COG0802	atpase or kinase
H1I66_11245	COG1187	pseudouridine synthase activity
H1I66_11260	COG0583	DNA-binding transcription factor activity
H1I66_11275	COG2814	Major facilitator Superfamily
H1I66_11280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I66_11305	COG0729	surface antigen
H1I66_11325	COG0174	glutamine synthetase
H1I66_11330	COG0745	RESPONSE REGULATOR receiver
H1I66_11335	COG2205	protein histidine kinase activity
H1I66_11345	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H1I66_11350	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H1I66_11375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I66_11380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I66_11385	COG1960	acyl-CoA dehydrogenase activity
H1I66_11400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I66_11405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I66_11425	COG0583	DNA-binding transcription factor activity
H1I66_11440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I66_11450	COG3658	cytochrome
H1I66_11455	COG1215	transferase activity, transferring glycosyl groups
H1I66_11460	COG1649	PFAM Uncharacterised BCR, COG1649
H1I66_11460	COG0726	polysaccharide deacetylase
H1I66_11485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H1I66_11490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1I66_11500	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H1I66_11525	COG0305	Participates in initiation and elongation during chromosome replication
H1I66_11530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1I66_11540	COG1305	Transglutaminase-like
H1I66_11550	COG2308	Evidence 4 Homologs of previously reported genes of
H1I66_11580	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H1I66_11585	COG0138	bifunctional purine biosynthesis protein purh
H1I66_11590	COG0151	Belongs to the GarS family
H1I66_11595	COG1464	Belongs to the NlpA lipoprotein family
H1I66_11600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I66_11605	COG2011	ABC-type metal ion transport system permease component
H1I66_11610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I66_11620	COG1301	dicarboxylic acid transport
H1I66_11655	COG1116	anion transmembrane transporter activity
H1I66_11660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I66_11670	COG0864	Transcriptional regulator
H1I66_11690	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I66_11695	COG0439	Biotin carboxylase
H1I66_11710	COG1063	alcohol dehydrogenase
H1I66_11720	COG1309	transcriptional regulator
H1I66_11740	COG0038	chloride channel
H1I66_11745	COG4770	biotin carboxylase activity
H1I66_11765	COG1914	H( )-stimulated, divalent metal cation uptake system
H1I66_11770	COG0583	DNA-binding transcription factor activity
H1I66_11820	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I66_11840	COG2814	Major facilitator Superfamily
H1I66_11850	COG1560	Kdo2-lipid A biosynthetic process
H1I66_11860	COG5006	permease, DMT superfamily
H1I66_11865	COG1522	sequence-specific DNA binding
H1I66_11880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1I66_11890	COG4122	O-methyltransferase activity
H1I66_11920	COG1538	Outer membrane efflux protein
H1I66_11925	COG1137	ATPase activity
H1I66_11930	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H1I66_11940	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H1I66_11945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H1I66_11945	COG0517	IMP dehydrogenase activity
H1I66_11980	COG2814	Major facilitator Superfamily
H1I66_12015	COG1278	Cold shock
H1I66_12020	COG1280	lysine exporter protein (LysE YggA)
H1I66_12050	COG1570	exodeoxyribonuclease VII activity
H1I66_12100	COG0583	DNA-binding transcription factor activity
H1I66_12105	COG4638	Rieske (2fe-2S)
H1I66_12110	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I66_12115	COG0633	Ferredoxin
H1I66_12115	COG0543	2 iron, 2 sulfur cluster binding
H1I66_12120	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_12125	COG3135	benzoate transporter
H1I66_12130	COG2814	Major facilitator Superfamily
H1I66_12145	COG1643	Atp-dependent helicase
H1I66_12150	COG0450	alkyl hydroperoxide reductase
H1I66_12160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1I66_12170	COG3634	alkyl hydroperoxide reductase activity
H1I66_12190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H1I66_12195	COG0625	glutathione transferase activity
H1I66_12205	COG2885	chlorophyll binding
H1I66_12240	COG0542	response to heat
H1I66_12255	COG1765	OsmC-like protein
H1I66_12270	COG0667	Aldo Keto reductase
H1I66_12285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H1I66_12295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H1I66_12315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H1I66_12325	COG3038	cytochrome b561
H1I66_12330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H1I66_12335	COG2252	PERMEase
H1I66_12345	COG2072	flavoprotein involved in K transport
H1I66_12370	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I66_12370	COG1902	pentaerythritol trinitrate reductase activity
H1I66_12380	COG5001	Diguanylate cyclase
H1I66_12380	COG4251	negative regulation of phosphorylation
H1I66_12380	COG3706	GGDEF domain
H1I66_12380	COG2203	Gaf domain
H1I66_12390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I66_12410	COG4172	Belongs to the ABC transporter superfamily
H1I66_12415	COG4239	(ABC) transporter, permease
H1I66_12420	COG4174	ABC transporter (Permease)
H1I66_12430	COG0741	lytic transglycosylase activity
H1I66_12430	COG0741	lytic transglycosylase activity
H1I66_12430	COG1388	LysM domain
H1I66_12430	COG1388	LysM domain
H1I66_12435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I66_12475	COG0583	DNA-binding transcription factor activity
H1I66_12480	COG1279	arginine transmembrane transporter activity
H1I66_12500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I66_12505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I66_12510	COG0006	proline dipeptidase activity
H1I66_12545	COG2194	sulfuric ester hydrolase activity
H1I66_12590	COG0739	heme binding
H1I66_12920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H1I66_12945	COG3384	dioxygenase
H1I66_12955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I66_12960	COG2878	Part of a membrane complex involved in electron transport
H1I66_12965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H1I66_12990	COG0768	penicillin binding
H1I66_12995	COG0742	ribosomal rna small subunit methyltransferase
H1I66_13010	COG0830	nickel cation binding
H1I66_13060	COG1253	flavin adenine dinucleotide binding
H1I66_13065	COG2851	Citrate transporter
H1I66_13120	COG1773	rubredoxin
H1I66_13125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I66_13135	COG0583	DNA-binding transcription factor activity
H1I66_13160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H1I66_13165	COG4181	ATPase activity
H1I66_13210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H1I66_13230	COG0306	phosphate transporter
H1I66_13240	COG3958	Transketolase
H1I66_13245	COG3959	Transketolase, thiamine diphosphate binding domain
H1I66_13250	COG2271	Major facilitator Superfamily
H1I66_13255	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_13260	COG0583	DNA-binding transcription factor activity
H1I66_13275	COG2223	nitrite transmembrane transporter activity
H1I66_13280	COG2207	Transcriptional regulator
H1I66_13285	COG2066	Belongs to the glutaminase family
H1I66_13290	COG0242	peptide deformylase activity
H1I66_13295	COG0477	Major facilitator Superfamily
H1I66_13305	COG0028	Belongs to the TPP enzyme family
H1I66_13320	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_13325	COG2267	carboxylic ester hydrolase activity
H1I66_13335	COG2271	Major facilitator Superfamily
H1I66_13340	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I66_13350	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_13370	COG1414	Transcriptional regulator
H1I66_13385	COG1024	Enoyl-CoA hydratase
H1I66_13395	COG1215	transferase activity, transferring glycosyl groups
H1I66_13400	COG0726	polysaccharide deacetylase
H1I66_13400	COG1649	PFAM Uncharacterised BCR, COG1649
H1I66_13410	COG4681	YaeQ
H1I66_13420	COG0523	cobalamin synthesis protein
H1I66_13430	COG1607	acyl-coa hydrolase
H1I66_13440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I66_13445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I66_13450	COG1309	transcriptional regulator
H1I66_13475	COG2040	homocysteine
H1I66_13480	COG0531	amino acid
H1I66_13535	COG1595	DNA-templated transcription, initiation
H1I66_13545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I66_13550	COG0477	Major facilitator Superfamily
H1I66_13570	COG0084	hydrolase, TatD family'
H1I66_13605	COG0629	single-stranded DNA binding
H1I66_13660	COG0582	viral genome integration into host DNA
H1I66_13755	COG0592	DNA-directed DNA polymerase activity
H1I66_13795	COG2026	Addiction module toxin, RelE StbE family
H1I66_13990	COG1484	DNA-dependent DNA replication
H1I66_14080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I66_14150	COG0405	Gamma-glutamyltransferase
H1I66_14155	COG2814	Major facilitator Superfamily
H1I66_14165	COG2050	protein possibly involved in aromatic compounds catabolism
H1I66_14180	COG1090	epimerase
H1I66_14200	COG0420	3'-5' exonuclease activity
H1I66_14225	COG0735	belongs to the Fur family
H1I66_14230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1I66_14250	COG0121	glutamine amidotransferase
H1I66_14265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I66_14275	COG0210	DNA helicase
H1I66_14280	COG2885	chlorophyll binding
H1I66_14285	COG0204	Acyl-transferase
H1I66_14300	COG2894	cell division
H1I66_14320	COG1280	lysine exporter protein (LysE YggA)
H1I66_14325	COG1674	ftsk spoiiie
H1I66_14325	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H1I66_14330	COG0492	ferredoxin-NADP+ reductase activity
H1I66_14335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H1I66_14345	COG0456	acetyltransferase
H1I66_14390	COG1981	membrane
H1I66_14405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I66_14405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H1I66_14425	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_14435	COG0657	acetylesterase activity
H1I66_14445	COG0473	3-isopropylmalate dehydrogenase activity
H1I66_14450	COG0583	DNA-binding transcription factor activity
H1I66_14470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I66_14495	COG0564	pseudouridine synthase activity
H1I66_14505	COG0358	DNA primase activity
H1I66_14520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H1I66_14550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I66_14580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1I66_14590	COG0352	thiamine-phosphate diphosphorylase activity
H1I66_14590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I66_14590	COG0351	phosphomethylpyrimidine kinase
H1I66_14595	COG1652	LysM domain
H1I66_14620	COG1399	metal-binding, possibly nucleic acid-binding protein
H1I66_14625	COG3101	peptidyl-lysine hydroxylation
H1I66_14630	COG0009	L-threonylcarbamoyladenylate synthase
H1I66_14635	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H1I66_14640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H1I66_14655	COG4106	trans-aconitate 2-methyltransferase activity
H1I66_14670	COG0596	Alpha beta hydrolase
H1I66_14670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I66_14670	COG2226	methyltransferase
H1I66_14675	COG1877	trehalose-phosphatase activity
H1I66_14680	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H1I66_14685	COG2223	nitrite transmembrane transporter activity
H1I66_14705	COG1196	nuclear chromosome segregation
H1I66_14715	COG0730	response to heat
H1I66_14730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H1I66_14740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I66_14790	COG0489	protein tyrosine kinase activity
H1I66_14800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I66_14800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I66_14830	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H1I66_14835	COG2081	HI0933 family
H1I66_14845	COG0668	transmembrane transport
H1I66_14865	COG0583	DNA-binding transcription factor activity
H1I66_14885	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1I66_14890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I66_14920	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H1I66_14960	COG0745	RESPONSE REGULATOR receiver
H1I66_14980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H1I66_14990	COG2205	protein histidine kinase activity
H1I66_15060	COG4993	Dehydrogenase
H1I66_15085	COG0384	phenazine biosynthesis protein PhzF
H1I66_15105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I66_15120	COG0583	DNA-binding transcription factor activity
H1I66_15150	COG0583	DNA-binding transcription factor activity
H1I66_15165	COG0583	DNA-binding transcription factor activity
H1I66_15170	COG1053	succinate dehydrogenase
H1I66_15180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H1I66_15185	COG2814	Major facilitator Superfamily
H1I66_15190	COG1960	acyl-CoA dehydrogenase activity
H1I66_15195	COG0583	DNA-binding transcription factor activity
H1I66_15200	COG1063	alcohol dehydrogenase
H1I66_15230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H1I66_15235	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H1I66_15240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I66_15255	COG3667	copper resistance
H1I66_15260	COG2132	Multicopper oxidase
H1I66_15270	COG0561	phosphatase activity
H1I66_15275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H1I66_15300	COG1214	PFAM Peptidase M22, glycoprotease
H1I66_15355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1I66_15365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H1I66_15370	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H1I66_15375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H1I66_15435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I66_15445	COG1846	Transcriptional regulator
H1I66_15450	COG1764	response to oxidative stress
H1I66_15500	COG0037	tRNA processing
H1I66_15510	COG0248	Ppx GppA phosphatase
H1I66_15540	COG0072	phenylalanine-tRNA ligase activity
H1I66_15580	COG1238	metal cluster binding
H1I66_15585	COG0625	glutathione transferase activity
H1I66_15600	COG0318	PFAM AMP-dependent synthetase and ligase
H1I66_15605	COG3028	Belongs to the UPF0307 family
H1I66_15610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I66_15630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H1I66_15635	COG0617	tRNA 3'-terminal CCA addition
H1I66_15640	COG1555	photosystem II stabilization
H1I66_15645	COG3956	TIGRFAM MazG family protein
H1I66_15655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I66_15675	COG5002	protein histidine kinase activity
H1I66_15675	COG0784	Response regulator, receiver
H1I66_15675	COG2205	protein histidine kinase activity
H1I66_15680	COG1024	Enoyl-CoA hydratase
H1I66_15685	COG2084	Dehydrogenase
H1I66_15690	COG3622	Belongs to the hyi family
H1I66_15720	COG0697	spore germination
H1I66_15730	COG2814	Major facilitator Superfamily
H1I66_15735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I66_15745	COG0583	DNA-binding transcription factor activity
H1I66_15755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H1I66_15770	COG0084	hydrolase, TatD family'
H1I66_15785	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H1I66_15815	COG0440	acetolactate synthase activity
H1I66_15820	COG0028	Belongs to the TPP enzyme family
H1I66_15845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I66_15850	COG0577	efflux transmembrane transporter activity
H1I66_15850	COG1136	(ABC) transporter
H1I66_15855	COG1538	Outer membrane efflux protein
H1I66_15870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H1I66_15875	COG1162	GTPase activity
H1I66_15885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1I66_15905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1I66_15910	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_15950	COG2986	histidine ammonia-lyase
H1I66_15965	COG0318	PFAM AMP-dependent synthetase and ligase
H1I66_15975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1I66_16020	COG1426	Protein conserved in bacteria
H1I66_16055	COG0793	Belongs to the peptidase S41A family
H1I66_16070	COG2267	carboxylic ester hydrolase activity
H1I66_16080	COG1012	belongs to the aldehyde dehydrogenase family
H1I66_16085	COG3265	gluconokinase activity
H1I66_16095	COG0800	Aldolase
H1I66_16110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H1I66_16115	COG0857	belongs to the CobB CobQ family
H1I66_16115	COG0280	phosphate acetyltransferase
H1I66_16120	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I66_16120	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I66_16140	COG0740	serine-type endopeptidase activity
H1I66_16150	COG4774	siderophore transport
H1I66_16160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1I66_16170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I66_16170	COG2813	Specifically methylates the guanine in position
H1I66_16270	COG0788	formyltetrahydrofolate deformylase activity
H1I66_16295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I66_16295	COG4651	solute:proton antiporter activity
H1I66_16315	COG0724	RNA recognition motif
H1I66_16320	COG0210	DNA helicase
H1I66_16345	COG1733	regulation of RNA biosynthetic process
H1I66_16355	COG2900	Belongs to the SlyX family
H1I66_16360	COG0488	(ABC) transporter
H1I66_16365	COG1280	lysine exporter protein (LysE YggA)
H1I66_16370	COG1560	Kdo2-lipid A biosynthetic process
H1I66_16380	COG1301	dicarboxylic acid transport
H1I66_16435	COG0473	3-isopropylmalate dehydrogenase activity
H1I66_16500	COG0583	DNA-binding transcription factor activity
H1I66_16510	COG0625	glutathione transferase activity
H1I66_16515	COG2378	regulation of single-species biofilm formation
H1I66_16520	COG0546	phosphoglycolate phosphatase activity
H1I66_16530	COG1530	ribonuclease E activity
H1I66_16535	COG0318	PFAM AMP-dependent synthetase and ligase
H1I66_16550	COG0583	DNA-binding transcription factor activity
H1I66_16555	COG4221	oxidoreductase activity
H1I66_16560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1I66_16570	COG0534	Mate efflux family protein
H1I66_16585	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H1I66_16625	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H1I66_16630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I66_16645	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I66_16655	COG0644	oxidoreductase
H1I66_16655	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H1I66_16660	COG0425	Belongs to the sulfur carrier protein TusA family
H1I66_16665	COG4535	Mg2 and Co2 transporter CorC
H1I66_16675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I66_16695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H1I66_16700	COG0475	glutathione-regulated potassium exporter activity
H1I66_16700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I66_16705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H1I66_16715	COG0484	heat shock protein binding
H1I66_16720	COG0789	Transcriptional regulator
H1I66_16725	COG0598	Magnesium transport protein CorA
H1I66_16740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I66_16745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I66_16750	COG1074	ATP-dependent DNA helicase activity
H1I66_16755	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H1I66_16775	COG2226	methyltransferase
H1I66_16790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I66_16795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H1I66_16810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I66_16810	COG2111	Na H antiporter
H1I66_16815	COG1006	Multisubunit Na H antiporter MnhC subunit
H1I66_16820	COG0651	ATP synthesis coupled electron transport
H1I66_16825	COG1863	multisubunit Na H antiporter MnhE subunit
H1I66_16830	COG2212	antiporter activity
H1I66_16835	COG1320	monovalent cation:proton antiporter activity
H1I66_16850	COG0195	Participates in both transcription termination and antitermination
H1I66_16900	COG0237	dephospho-CoA kinase activity
H1I66_16910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I66_16925	COG0497	DNA recombination
H1I66_16935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H1I66_16965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I66_16965	COG2169	Transcriptional regulator
H1I66_16970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H1I66_17035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H1I66_17050	COG0326	Molecular chaperone. Has ATPase activity
H1I66_17070	COG0596	Alpha beta hydrolase
H1I66_17165	COG0546	phosphoglycolate phosphatase activity
H1I66_17170	COG1716	ATPase activity
H1I66_17215	COG0181	hydroxymethylbilane synthase activity
H1I66_17225	COG3275	phosphorelay sensor kinase activity
H1I66_17245	COG1538	Outer membrane efflux protein
H1I66_17250	COG0697	spore germination
H1I66_17275	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I66_17280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H1I66_17285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I66_17290	COG0772	Belongs to the SEDS family
H1I66_17315	COG4974	Belongs to the 'phage' integrase family
H1I66_17320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I66_17330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H1I66_17340	COG2197	response regulator
H1I66_17355	COG0793	Belongs to the peptidase S41A family
H1I66_17360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H1I66_17365	COG0795	lipopolysaccharide-transporting ATPase activity
H1I66_17405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I66_17405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I66_17415	COG0004	ammonium transporteR
H1I66_17420	COG0347	Belongs to the P(II) protein family
H1I66_17430	COG0606	chelatase, subunit chli
H1I66_17500	COG1061	Type III restriction enzyme res subunit
H1I66_17515	COG0659	secondary active sulfate transmembrane transporter activity
H1I66_17520	COG0589	response to stress
H1I66_17550	COG0606	chelatase, subunit chli
H1I66_17565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I66_17580	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H1I66_17595	COG0318	PFAM AMP-dependent synthetase and ligase
H1I66_17605	COG0477	Major facilitator Superfamily
H1I66_17610	COG2860	membrane
H1I66_17620	COG1253	flavin adenine dinucleotide binding
H1I66_17640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1I66_17675	COG0655	NAD(P)H dehydrogenase (quinone) activity
H1I66_17685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H1I66_17720	COG1309	transcriptional regulator
H1I66_17755	COG0758	DNA mediated transformation
H1I66_17765	COG0697	spore germination
H1I66_17770	COG1309	transcriptional regulator
H1I66_17785	COG0386	Belongs to the glutathione peroxidase family
H1I66_17860	COG1061	Type III restriction enzyme res subunit
H1I66_17870	COG1192	Involved in chromosome partitioning
H1I66_17875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I66_17885	COG1061	Type III restriction enzyme res subunit
H1I66_17900	COG1121	(ABC) transporter
H1I66_17905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1I66_17910	COG1280	lysine exporter protein (LysE YggA)
H1I66_17915	COG2837	iron assimilation
H1I66_17925	COG0281	malic enzyme
H1I66_17970	COG0519	Catalyzes the synthesis of GMP from XMP
H1I66_17970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I66_17975	COG4399	Belongs to the UPF0754 family
H1I66_17980	COG2259	Doxx family
H1I66_17985	COG0586	Pfam SNARE associated Golgi protein
H1I66_18000	COG1192	Involved in chromosome partitioning
H1I66_18010	COG0271	Belongs to the BolA IbaG family
H1I66_18030	COG2267	carboxylic ester hydrolase activity
H1I66_18050	COG3321	synthase
H1I66_18050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H1I66_18050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1I66_18050	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H1I66_18055	COG1960	acyl-CoA dehydrogenase activity
H1I66_18065	COG2197	response regulator
H1I66_18075	COG3916	Acyl-homoserine-lactone synthase
H1I66_18080	COG0477	Major facilitator Superfamily
H1I66_18085	COG1024	Enoyl-CoA hydratase
H1I66_18090	COG1024	Enoyl-CoA hydratase
H1I66_18095	COG1960	acyl-CoA dehydrogenase activity
H1I66_18100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I66_18120	COG1113	amino acid transport
H1I66_18125	COG1113	amino acid transport
H1I66_18130	COG0251	oxidation-reduction process
H1I66_18170	COG0564	pseudouridine synthase activity
H1I66_18230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H1I66_18245	COG1802	Transcriptional regulator
H1I66_18255	COG1448	Aminotransferase
H1I66_18260	COG0277	FAD linked oxidase domain protein
H1I66_18270	COG2186	Transcriptional regulator
H1I66_18280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I66_18285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I66_18300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H1I66_18320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1I66_18325	COG0438	transferase activity, transferring glycosyl groups
H1I66_18345	COG1216	Glycosyl transferase, family 2
H1I66_18350	COG5039	Polysaccharide pyruvyl transferase
H1I66_18360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H1I66_18365	COG1596	polysaccharide export
H1I66_18390	COG0728	peptidoglycan biosynthetic process
H1I66_18395	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1I66_18450	COG0546	phosphoglycolate phosphatase activity
H1I66_18455	COG1028	Short-chain dehydrogenase reductase Sdr
H1I66_18475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I66_18480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I66_18485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I66_18490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I66_18495	COG1116	anion transmembrane transporter activity
H1I66_18500	COG1309	transcriptional regulator
H1I66_18505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1I66_18515	COG0196	riboflavin kinase activity
H1I66_18520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H1I66_18530	COG1047	Peptidyl-prolyl cis-trans
H1I66_18570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H1I66_18575	COG0657	acetylesterase activity
H1I66_18625	COG2951	lytic endotransglycosylase activity
H1I66_18630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H1I66_18645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H1I66_18655	COG0671	phosphoesterase, PA-phosphatase related
H1I66_18660	COG0861	Integral membrane protein TerC family
H1I66_18670	COG0754	glutathionylspermidine amidase activity
H1I66_18680	COG0402	S-adenosylhomocysteine deaminase activity
H1I66_18695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I66_18700	COG1230	cation diffusion facilitator family transporter
H1I66_18715	COG0706	membrane insertase activity