locus-tag	class	description
H1I67_00010	COG0592	DNA-directed DNA polymerase activity
H1I67_00020	COG0187	DNA topoisomerase II activity
H1I67_00030	COG0586	Pfam SNARE associated Golgi protein
H1I67_00035	COG0488	(ABC) transporter
H1I67_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H1I67_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H1I67_00105	COG0733	neurotransmitter:sodium symporter activity
H1I67_00145	COG2233	PERMEase
H1I67_00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I67_00195	COG2814	Major facilitator Superfamily
H1I67_00200	COG0656	L-ascorbic acid biosynthetic process
H1I67_00205	COG0583	DNA-binding transcription factor activity
H1I67_00220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I67_00225	COG1064	alcohol dehydrogenase
H1I67_00230	COG2818	Glycosylase
H1I67_00245	COG1194	a g-specific adenine glycosylase
H1I67_00265	COG2983	Belongs to the UPF0260 family
H1I67_00270	COG2133	pyrroloquinoline quinone binding
H1I67_00275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H1I67_00280	COG2116	formate transmembrane transporter activity
H1I67_00300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I67_00305	COG1335	isochorismatase
H1I67_00310	COG0385	Bile acid
H1I67_00315	COG0534	Mate efflux family protein
H1I67_00320	COG1683	Conserved Protein
H1I67_00340	COG0625	glutathione transferase activity
H1I67_00350	COG1113	amino acid transport
H1I67_00360	COG0523	cobalamin synthesis protein
H1I67_00370	COG2188	Transcriptional regulator
H1I67_00400	COG0010	Belongs to the arginase family
H1I67_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I67_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1I67_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H1I67_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H1I67_00540	COG0534	Mate efflux family protein
H1I67_00545	COG0436	Aminotransferase
H1I67_00550	COG2733	membrane
H1I67_00565	COG2918	glutathione biosynthetic process
H1I67_00585	COG1388	LysM domain
H1I67_00585	COG0791	NLP P60 protein
H1I67_00605	COG3150	esterase
H1I67_00615	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_00620	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H1I67_00630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I67_00640	COG2233	PERMEase
H1I67_00645	COG2351	hydroxyisourate hydrolase activity
H1I67_00680	COG3706	GGDEF domain
H1I67_00695	COG1393	Belongs to the ArsC family
H1I67_00700	COG0708	Exodeoxyribonuclease III
H1I67_00720	COG0189	ligase activity
H1I67_00740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H1I67_00750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1I67_00765	COG4942	peptidase
H1I67_00775	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I67_00785	COG2119	membrane
H1I67_00790	COG4774	siderophore transport
H1I67_00795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I67_00795	COG0426	domain, Protein
H1I67_00820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H1I67_00840	COG1902	pentaerythritol trinitrate reductase activity
H1I67_00845	COG1519	Transferase
H1I67_00850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I67_00855	COG0668	transmembrane transport
H1I67_00865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I67_00870	COG1335	isochorismatase
H1I67_00875	COG1522	sequence-specific DNA binding
H1I67_00880	COG3328	transposase activity
H1I67_00905	COG0784	Response regulator, receiver
H1I67_00905	COG2198	Histidine kinase
H1I67_00905	COG2205	protein histidine kinase activity
H1I67_00910	COG3162	membrane
H1I67_00915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I67_00925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I67_00945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H1I67_00950	COG1309	transcriptional regulator
H1I67_00970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I67_00970	COG0351	phosphomethylpyrimidine kinase
H1I67_00970	COG0352	thiamine-phosphate diphosphorylase activity
H1I67_00980	COG2814	Major facilitator Superfamily
H1I67_01015	COG1002	Type II restriction enzyme, methylase subunits
H1I67_01025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I67_01035	COG1061	Type III restriction enzyme res subunit
H1I67_01040	COG1002	Type II restriction enzyme, methylase subunits
H1I67_01050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I67_01060	COG1113	amino acid transport
H1I67_01070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I67_01075	COG1012	belongs to the aldehyde dehydrogenase family
H1I67_01085	COG1335	isochorismatase
H1I67_01115	COG2814	Major facilitator Superfamily
H1I67_01120	COG0583	DNA-binding transcription factor activity
H1I67_01140	COG0667	Aldo Keto reductase
H1I67_01170	COG1733	regulation of RNA biosynthetic process
H1I67_01175	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I67_01240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H1I67_01255	COG2329	Antibiotic biosynthesis monooxygenase
H1I67_01285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H1I67_01315	COG0427	acetyl-CoA hydrolase
H1I67_01340	COG0659	secondary active sulfate transmembrane transporter activity
H1I67_01345	COG4221	oxidoreductase activity
H1I67_01350	COG2873	o-acetylhomoserine
H1I67_01355	COG0488	(ABC) transporter
H1I67_01440	COG0833	amino acid
H1I67_01485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H1I67_01490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H1I67_01505	COG2226	methyltransferase
H1I67_01555	COG0069	glutamate synthase activity
H1I67_01555	COG0070	glutamate synthase
H1I67_01555	COG0067	glutamate synthase
H1I67_01560	COG0493	'glutamate synthase
H1I67_01570	COG1704	LemA family
H1I67_01575	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H1I67_01590	COG4969	Belongs to the N-Me-Phe pilin family
H1I67_01595	COG3307	-O-antigen
H1I67_01615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I67_01625	COG0194	GDP metabolic process
H1I67_01675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H1I67_01695	COG5380	lipid catabolic process
H1I67_01700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H1I67_01725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1I67_01740	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H1I67_01745	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I67_01760	COG1289	transmembrane transporter activity
H1I67_01770	COG0628	permease
H1I67_01775	COG1192	Involved in chromosome partitioning
H1I67_01805	COG0833	amino acid
H1I67_01810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I67_01815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I67_01825	COG1012	belongs to the aldehyde dehydrogenase family
H1I67_01865	COG0583	DNA-binding transcription factor activity
H1I67_01910	COG0517	IMP dehydrogenase activity
H1I67_01915	COG1983	PspC domain protein
H1I67_01925	COG1960	acyl-CoA dehydrogenase activity
H1I67_01960	COG0513	Belongs to the DEAD box helicase family
H1I67_01970	COG1127	ABC transporter
H1I67_01975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H1I67_01985	COG2854	intermembrane phospholipid transfer
H1I67_01995	COG0598	Magnesium transport protein CorA
H1I67_02005	COG0494	nUDIX hydrolase
H1I67_02010	COG1040	competence protein
H1I67_02015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H1I67_02035	COG1946	Acyl-CoA thioesterase
H1I67_02040	COG1301	dicarboxylic acid transport
H1I67_02055	COG1959	2 iron, 2 sulfur cluster binding
H1I67_02060	COG1017	nitric oxide dioxygenase activity
H1I67_02060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I67_02065	COG0433	COG0433 Predicted ATPase
H1I67_02070	COG0626	cystathionine gamma-synthase activity
H1I67_02225	COG1960	acyl-CoA dehydrogenase activity
H1I67_02230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H1I67_02260	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H1I67_02265	COG0339	signal peptide processing
H1I67_02270	COG0557	exoribonuclease II activity
H1I67_02315	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1I67_02320	COG2169	Transcriptional regulator
H1I67_02325	COG0697	spore germination
H1I67_02330	COG1295	ribonuclease BN
H1I67_02365	COG1702	phosphate starvation-inducible protein PhoH
H1I67_02375	COG0739	heme binding
H1I67_02375	COG0741	lytic transglycosylase activity
H1I67_02375	COG1196	nuclear chromosome segregation
H1I67_02405	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H1I67_02410	COG1183	phosphatidylcholine synthase activity
H1I67_02455	COG1960	acyl-CoA dehydrogenase activity
H1I67_02460	COG1309	transcriptional regulator
H1I67_02475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I67_02480	COG1960	acyl-CoA dehydrogenase activity
H1I67_02500	COG2969	positive regulation of protein catabolic process
H1I67_02510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H1I67_02525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1I67_02530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H1I67_02550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1I67_02560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I67_02565	COG1408	metallophosphoesterase
H1I67_02575	COG2199	diguanylate cyclase activity
H1I67_02635	COG1607	acyl-coa hydrolase
H1I67_02665	COG2350	Protein conserved in bacteria
H1I67_02675	COG0613	PHP domain protein
H1I67_02680	COG3781	membrane
H1I67_02690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H1I67_02695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H1I67_02705	COG1862	Preprotein translocase
H1I67_02750	COG2205	protein histidine kinase activity
H1I67_02755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H1I67_02775	COG0726	polysaccharide deacetylase
H1I67_02780	COG0463	Glycosyl transferase, family 2
H1I67_02785	COG0438	transferase activity, transferring glycosyl groups
H1I67_02850	COG0625	glutathione transferase activity
H1I67_02855	COG0583	DNA-binding transcription factor activity
H1I67_02860	COG1960	acyl-CoA dehydrogenase activity
H1I67_02865	COG1960	acyl-CoA dehydrogenase activity
H1I67_02875	COG2205	protein histidine kinase activity
H1I67_02880	COG0745	RESPONSE REGULATOR receiver
H1I67_02885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H1I67_02905	COG2096	Adenosyltransferase
H1I67_02955	COG0285	dihydrofolate synthase activity
H1I67_02975	COG0450	alkyl hydroperoxide reductase
H1I67_02990	COG0477	Major facilitator Superfamily
H1I67_02995	COG1272	protein, Hemolysin III
H1I67_03025	COG0183	Belongs to the thiolase family
H1I67_03030	COG2207	Transcriptional regulator
H1I67_03050	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I67_03070	COG0183	Belongs to the thiolase family
H1I67_03080	COG2885	chlorophyll binding
H1I67_03080	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H1I67_03090	COG1690	Belongs to the RtcB family
H1I67_03095	COG0833	amino acid
H1I67_03105	COG2233	PERMEase
H1I67_03110	COG1217	gtp-binding protein TYPA
H1I67_03135	COG2094	Belongs to the DNA glycosylase MPG family
H1I67_03140	COG4772	TonB-dependent receptor
H1I67_03155	COG1902	pentaerythritol trinitrate reductase activity
H1I67_03170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I67_03175	COG0354	folic acid binding
H1I67_03185	COG3189	MarR family transcriptional regulator
H1I67_03190	COG2824	Alkylphosphonate utilization operon protein PhnA
H1I67_03195	COG3422	double-strand break repair
H1I67_03235	COG0840	transmembrane signaling receptor activity
H1I67_03255	COG5510	response to toxic substance
H1I67_03265	COG2832	Protein of unknown function (DUF454)
H1I67_03270	COG1376	ErfK ybiS ycfS ynhG family protein
H1I67_03310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H1I67_03320	COG1289	transmembrane transporter activity
H1I67_03325	COG2814	Major facilitator Superfamily
H1I67_03345	COG1115	amino acid carrier protein
H1I67_03350	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I67_03355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I67_03360	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H1I67_03390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I67_03400	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H1I67_03405	COG1077	Cell shape determining protein MreB Mrl
H1I67_03410	COG1792	Involved in formation and maintenance of cell shape
H1I67_03415	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H1I67_03420	COG0424	maF-like protein
H1I67_03425	COG1530	ribonuclease E activity
H1I67_03435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I67_03445	COG0560	Phosphoserine phosphatase
H1I67_03455	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I67_03480	COG2207	Transcriptional regulator
H1I67_03500	COG1113	amino acid transport
H1I67_03505	COG2828	Protein conserved in bacteria
H1I67_03510	COG0142	geranyltranstransferase activity
H1I67_03515	COG2315	Protein conserved in bacteria
H1I67_03530	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1I67_03555	COG0745	RESPONSE REGULATOR receiver
H1I67_03560	COG0642	Histidine kinase
H1I67_03570	COG0004	ammonium transporteR
H1I67_03575	COG0583	DNA-binding transcription factor activity
H1I67_03595	COG0525	valine-tRNA ligase activity
H1I67_03605	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_03615	COG0393	Putative heavy-metal-binding
H1I67_03620	COG0393	Putative heavy-metal-binding
H1I67_03625	COG1538	Outer membrane efflux protein
H1I67_03635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I67_03640	COG0671	phosphoesterase, PA-phosphatase related
H1I67_03670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H1I67_03685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H1I67_03685	COG1648	precorrin-2 dehydrogenase activity
H1I67_03690	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H1I67_03695	COG1733	regulation of RNA biosynthetic process
H1I67_03705	COG0531	amino acid
H1I67_03725	COG0321	lipoyl(octanoyl) transferase activity
H1I67_03730	COG2921	Belongs to the UPF0250 family
H1I67_03770	COG2009	succinate dehydrogenase
H1I67_03775	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H1I67_03780	COG1053	succinate dehydrogenase
H1I67_03785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H1I67_03810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I67_03830	COG2354	Protein conserved in bacteria
H1I67_03835	COG2321	neutral zinc metallopeptidase
H1I67_03870	COG2843	Capsule synthesis protein
H1I67_03885	COG0589	response to stress
H1I67_03905	COG0505	Belongs to the CarA family
H1I67_03930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I67_03935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H1I67_03985	COG0477	Major facilitator Superfamily
H1I67_03990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H1I67_04005	COG1597	lipid kinase activity
H1I67_04010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1I67_04040	COG0584	glycerophosphoryl diester phosphodiesterase
H1I67_04060	COG0741	lytic transglycosylase activity
H1I67_04080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1I67_04095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I67_04120	COG0778	Nitroreductase
H1I67_04135	COG1929	Belongs to the glycerate kinase type-1 family
H1I67_04140	COG0243	molybdopterin cofactor binding
H1I67_04145	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H1I67_04150	COG3339	Conserved Protein
H1I67_04160	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H1I67_04175	COG1113	amino acid transport
H1I67_04185	COG0019	diaminopimelate decarboxylase activity
H1I67_04195	COG1280	lysine exporter protein (LysE YggA)
H1I67_04200	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H1I67_04230	COG0463	Glycosyl transferase, family 2
H1I67_04250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I67_04285	COG4591	ABC-type transport system involved in lipoprotein release permease component
H1I67_04290	COG1136	(ABC) transporter
H1I67_04295	COG0658	competence protein
H1I67_04295	COG2333	competence protein COMEC
H1I67_04305	COG0616	signal peptide processing
H1I67_04305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H1I67_04310	COG0596	Alpha beta hydrolase
H1I67_04315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H1I67_04325	COG0628	permease
H1I67_04360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I67_04380	COG0823	Involved in the tonB-independent uptake of proteins
H1I67_04400	COG0824	Thioesterase
H1I67_04405	COG1473	amidohydrolase
H1I67_04425	COG0047	phosphoribosylformylglycinamidine synthase activity
H1I67_04425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1I67_04430	COG2814	Major facilitator Superfamily
H1I67_04440	COG1024	Enoyl-CoA hydratase
H1I67_04445	COG1051	belongs to the nudix hydrolase family
H1I67_04445	COG1056	cytidyltransferase-related domain
H1I67_04455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H1I67_04470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H1I67_04485	COG4625	pathogenesis
H1I67_04490	COG0583	DNA-binding transcription factor activity
H1I67_04495	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1I67_04500	COG4208	sulfate ABC transporter
H1I67_04505	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H1I67_04515	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H1I67_04520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1I67_04525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H1I67_04545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I67_04560	COG0681	Belongs to the peptidase S26 family
H1I67_04590	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H1I67_04600	COG4221	oxidoreductase activity
H1I67_04630	COG0436	Aminotransferase
H1I67_04650	COG0556	nucleotide-excision repair
H1I67_04705	COG2070	2-Nitropropane dioxygenase
H1I67_04735	COG1215	transferase activity, transferring glycosyl groups
H1I67_04750	COG0415	Belongs to the DNA photolyase family
H1I67_04760	COG1252	NADH dehydrogenase
H1I67_04765	COG1686	Belongs to the peptidase S11 family
H1I67_04780	COG1187	pseudouridine synthase activity
H1I67_04805	COG0477	Major facilitator Superfamily
H1I67_04810	COG0583	DNA-binding transcription factor activity
H1I67_04815	COG1823	symporter activity
H1I67_04825	COG0612	Peptidase, M16
H1I67_04850	COG0352	thiamine-phosphate diphosphorylase activity
H1I67_04885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I67_04900	COG1309	transcriptional regulator
H1I67_04910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1I67_04915	COG0076	glutamate decarboxylase activity
H1I67_04925	COG1522	sequence-specific DNA binding
H1I67_04930	COG3961	Belongs to the TPP enzyme family
H1I67_04935	COG1113	amino acid transport
H1I67_04940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I67_04945	COG0573	inorganic phosphate transmembrane transporter activity
H1I67_04955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1I67_04960	COG0616	signal peptide processing
H1I67_04970	COG3328	transposase activity
H1I67_05000	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H1I67_05005	COG1686	Belongs to the peptidase S11 family
H1I67_05030	COG0583	DNA-binding transcription factor activity
H1I67_05035	COG1067	ATP-dependent peptidase activity
H1I67_05080	COG1966	Carbon starvation protein
H1I67_05085	COG2879	small protein
H1I67_05115	COG2508	Transcriptional regulator
H1I67_05115	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H1I67_05135	COG1113	amino acid transport
H1I67_05140	COG0583	DNA-binding transcription factor activity
H1I67_05145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I67_05150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I67_05160	COG1012	belongs to the aldehyde dehydrogenase family
H1I67_05165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I67_05170	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H1I67_05170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I67_05205	COG2814	Major facilitator Superfamily
H1I67_05210	COG4948	Mandelate Racemase Muconate Lactonizing
H1I67_05220	COG1309	transcriptional regulator
H1I67_05240	COG1741	Belongs to the pirin family
H1I67_05250	COG2964	Protein conserved in bacteria
H1I67_05265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I67_05270	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I67_05275	COG4605	iron ion homeostasis
H1I67_05280	COG4604	ABC transporter, ATP-binding protein
H1I67_05285	COG4607	ABC-type enterochelin transport system periplasmic component
H1I67_05290	COG4774	siderophore transport
H1I67_05300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1I67_05305	COG1021	2,3-dihydroxybenzoate-AMP ligase
H1I67_05310	COG3433	isochorismatase activity
H1I67_05310	COG1535	isochorismatase
H1I67_05330	COG1132	(ABC) transporter
H1I67_05335	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H1I67_05345	COG1169	isochorismate synthase
H1I67_05360	COG3739	integral membrane protein
H1I67_05385	COG0302	gtp cyclohydrolase
H1I67_05395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H1I67_05425	COG0308	aminopeptidase N
H1I67_05430	COG0512	Glutamine amidotransferase of anthranilate synthase
H1I67_05445	COG0174	glutamine synthetase
H1I67_05455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H1I67_05490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H1I67_05495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H1I67_05500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1I67_05520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1I67_05525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H1I67_05530	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H1I67_05545	COG1960	acyl-CoA dehydrogenase activity
H1I67_05550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I67_05555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I67_05565	COG2223	nitrite transmembrane transporter activity
H1I67_05575	COG0024	Methionine aminopeptidase
H1I67_05580	COG0052	Belongs to the universal ribosomal protein uS2 family
H1I67_05595	COG2207	Transcriptional regulator
H1I67_05620	COG2951	lytic endotransglycosylase activity
H1I67_05625	COG0772	Belongs to the SEDS family
H1I67_05640	COG0842	Transport permease protein
H1I67_05645	COG1131	(ABC) transporter
H1I67_05690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I67_05705	COG4215	(ABC) transporter
H1I67_05710	COG4160	amino acid transport
H1I67_05715	COG4598	ABC transporter
H1I67_05725	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I67_05730	COG0826	peptidase U32
H1I67_05735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I67_05750	COG1720	tRNA m6t6A37 methyltransferase activity
H1I67_05760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H1I67_05775	COG0642	Histidine kinase
H1I67_05785	COG0494	nUDIX hydrolase
H1I67_05795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1I67_05800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H1I67_05805	COG3139	Protein of unknown function (DUF1315)
H1I67_05810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1I67_05815	COG1301	dicarboxylic acid transport
H1I67_05820	COG1960	acyl-CoA dehydrogenase activity
H1I67_05825	COG2819	hydrolase of the alpha beta superfamily
H1I67_05835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H1I67_05845	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1I67_05850	COG1234	tRNA 3'-trailer cleavage
H1I67_05880	COG2363	Small membrane protein
H1I67_05900	COG0513	Belongs to the DEAD box helicase family
H1I67_05910	COG0778	Nitroreductase
H1I67_05940	COG1286	toxin biosynthetic process
H1I67_05965	COG4783	chaperone-mediated protein folding
H1I67_05970	COG1610	YqeY-like protein
H1I67_06070	COG3111	PFAM Bacterial OB fold (BOF) protein
H1I67_06095	COG3243	poly(R)-hydroxyalkanoic acid synthase
H1I67_06100	COG0786	glutamate:sodium symporter activity
H1I67_06110	COG2186	Transcriptional regulator
H1I67_06160	COG0477	Major facilitator Superfamily
H1I67_06195	COG2995	paraquat-inducible protein a
H1I67_06200	COG3008	intermembrane lipid transfer
H1I67_06200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H1I67_06220	COG0482	sulfurtransferase activity
H1I67_06235	COG0488	(ABC) transporter
H1I67_06240	COG3173	Aminoglycoside phosphotransferase
H1I67_06250	COG2433	Pfam Transposase IS66
H1I67_06380	COG0590	tRNA wobble adenosine to inosine editing
H1I67_06385	COG2807	transmembrane transport
H1I67_06400	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H1I67_06415	COG0789	Transcriptional regulator
H1I67_06425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I67_06455	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I67_06470	COG1012	belongs to the aldehyde dehydrogenase family
H1I67_06475	COG0531	amino acid
H1I67_06480	COG1760	l-serine dehydratase
H1I67_06485	COG1012	belongs to the aldehyde dehydrogenase family
H1I67_06485	COG2030	dehydratase
H1I67_06490	COG3396	Phenylacetate-CoA oxygenase
H1I67_06495	COG3460	Phenylacetate-CoA oxygenase
H1I67_06500	COG3396	Phenylacetate-CoA oxygenase
H1I67_06505	COG2151	metal-sulfur cluster biosynthetic enzyme
H1I67_06510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I67_06515	COG1024	Enoyl-CoA hydratase
H1I67_06520	COG1024	Enoyl-CoA hydratase
H1I67_06525	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I67_06530	COG0183	Belongs to the thiolase family
H1I67_06535	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H1I67_06540	COG3327	negative regulation of DNA-templated transcription, initiation
H1I67_06550	COG2050	protein possibly involved in aromatic compounds catabolism
H1I67_06580	COG0753	catalase activity
H1I67_06585	COG3038	cytochrome b561
H1I67_06605	COG2267	carboxylic ester hydrolase activity
H1I67_06610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I67_06615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I67_06620	COG1012	belongs to the aldehyde dehydrogenase family
H1I67_06630	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I67_06640	COG1012	belongs to the aldehyde dehydrogenase family
H1I67_06645	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I67_06650	COG0583	DNA-binding transcription factor activity
H1I67_06660	COG1414	Transcriptional regulator
H1I67_06665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I67_06675	COG1840	ABC-type Fe3 transport system, periplasmic component
H1I67_06680	COG3842	ATPase activity
H1I67_06695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H1I67_06700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I67_06705	COG2814	Major facilitator Superfamily
H1I67_06710	COG1960	acyl-CoA dehydrogenase activity
H1I67_06725	COG1024	Enoyl-CoA hydratase
H1I67_06735	COG2814	Major facilitator Superfamily
H1I67_06745	COG0183	Belongs to the thiolase family
H1I67_06750	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I67_06755	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_06760	COG1024	Enoyl-CoA hydratase
H1I67_06765	COG1960	acyl-CoA dehydrogenase activity
H1I67_06770	COG2814	Major facilitator Superfamily
H1I67_06775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H1I67_06780	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I67_06790	COG2814	Major facilitator Superfamily
H1I67_06800	COG1960	acyl-CoA dehydrogenase activity
H1I67_06815	COG0583	DNA-binding transcription factor activity
H1I67_06825	COG4770	biotin carboxylase activity
H1I67_06830	COG1024	Enoyl-CoA hydratase
H1I67_06835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1I67_06840	COG1960	acyl-CoA dehydrogenase activity
H1I67_06845	COG1309	transcriptional regulator
H1I67_06850	COG0318	PFAM AMP-dependent synthetase and ligase
H1I67_06870	COG0583	DNA-binding transcription factor activity
H1I67_06920	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_06940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1I67_06960	COG2205	protein histidine kinase activity
H1I67_06960	COG0784	Response regulator, receiver
H1I67_06980	COG0765	amino acid transport
H1I67_06985	COG0765	amino acid transport
H1I67_06990	COG1126	abc transporter atp-binding protein
H1I67_06995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I67_07000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I67_07015	COG1280	lysine exporter protein (LysE YggA)
H1I67_07025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H1I67_07030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I67_07035	COG1045	serine acetyltransferase
H1I67_07050	COG0583	DNA-binding transcription factor activity
H1I67_07055	COG0625	glutathione transferase activity
H1I67_07060	COG0625	glutathione transferase activity
H1I67_07065	COG0583	DNA-binding transcription factor activity
H1I67_07075	COG1346	cytolysis
H1I67_07095	COG2814	Major facilitator Superfamily
H1I67_07105	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H1I67_07110	COG3052	prosthetic group binding
H1I67_07130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1I67_07150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I67_07160	COG1294	oxidase, subunit
H1I67_07165	COG1271	oxidase subunit
H1I67_07190	COG0477	Major facilitator Superfamily
H1I67_07200	COG4521	taurine ABC transporter
H1I67_07205	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H1I67_07210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I67_07215	COG2175	clavaminate synthase activity
H1I67_07225	COG1953	Uracil, thiamine, allantoin
H1I67_07235	COG0583	DNA-binding transcription factor activity
H1I67_07245	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H1I67_07260	COG0640	Transcriptional regulator
H1I67_07265	COG0798	PFAM Bile acid sodium symporter
H1I67_07270	COG0583	DNA-binding transcription factor activity
H1I67_07330	COG0436	Aminotransferase
H1I67_07340	COG0386	Belongs to the glutathione peroxidase family
H1I67_07380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1I67_07405	COG0012	GTP binding
H1I67_07410	COG2011	ABC-type metal ion transport system permease component
H1I67_07415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I67_07425	COG1464	Belongs to the NlpA lipoprotein family
H1I67_07455	COG0765	amino acid transport
H1I67_07460	COG0765	amino acid transport
H1I67_07465	COG1126	abc transporter atp-binding protein
H1I67_07475	COG1522	sequence-specific DNA binding
H1I67_07490	COG1309	transcriptional regulator
H1I67_07510	COG0583	DNA-binding transcription factor activity
H1I67_07520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1I67_07530	COG0697	spore germination
H1I67_07555	COG3121	Chaperone
H1I67_07560	COG3539	Fimbrial protein
H1I67_07630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H1I67_07640	COG2353	YceI-like domain
H1I67_07650	COG3698	Phosphodiester glycosidase
H1I67_07665	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H1I67_07670	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I67_07670	COG0506	proline dehydrogenase activity
H1I67_07670	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1I67_07680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1I67_07685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H1I67_07705	COG1132	(ABC) transporter
H1I67_07710	COG3122	Protein conserved in bacteria
H1I67_07715	COG3619	membrane
H1I67_07730	COG0640	Transcriptional regulator
H1I67_07740	COG2850	peptidyl-arginine hydroxylation
H1I67_07745	COG0424	maF-like protein
H1I67_07765	COG0191	fructose-bisphosphate aldolase activity
H1I67_07770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I67_07785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1I67_07795	COG1192	Involved in chromosome partitioning
H1I67_07800	COG1475	DNA binding
H1I67_07805	COG0811	peptide transport
H1I67_07815	COG1132	(ABC) transporter
H1I67_07820	COG1663	tetraacyldisaccharide 4'-kinase activity
H1I67_07840	COG0084	hydrolase, TatD family'
H1I67_07905	COG0776	regulation of translation
H1I67_07935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H1I67_07940	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H1I67_07990	COG0339	signal peptide processing
H1I67_08000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1I67_08035	COG0702	epimerase
H1I67_08040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I67_08060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H1I67_08090	COG0316	Belongs to the HesB IscA family
H1I67_08095	COG0822	iron-sulfur transferase activity
H1I67_08120	COG0776	regulation of translation
H1I67_08125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1I67_08130	COG2207	Transcriptional regulator
H1I67_08135	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I67_08140	COG1960	acyl-CoA dehydrogenase activity
H1I67_08145	COG1960	acyl-CoA dehydrogenase activity
H1I67_08160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1I67_08180	COG4264	IucA IucC family
H1I67_08185	COG4264	IucA IucC family
H1I67_08225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1I67_08240	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H1I67_08260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H1I67_08265	COG0730	response to heat
H1I67_08285	COG4773	Receptor
H1I67_08290	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I67_08305	COG1131	(ABC) transporter
H1I67_08310	COG0842	Transport permease protein
H1I67_08315	COG0842	Transport permease protein
H1I67_08370	COG2226	methyltransferase
H1I67_08395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H1I67_08430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1I67_08440	COG0133	tryptophan synthase activity
H1I67_08455	COG3706	GGDEF domain
H1I67_08470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1I67_08475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H1I67_08480	COG0022	dehydrogenase e1 component
H1I67_08485	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1I67_08490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1I67_08500	COG1063	alcohol dehydrogenase
H1I67_08505	COG3781	membrane
H1I67_08515	COG3453	Protein conserved in bacteria
H1I67_08515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I67_08525	COG0730	response to heat
H1I67_08545	COG2207	Transcriptional regulator
H1I67_08545	COG3708	Transcriptional regulator
H1I67_08550	COG1733	regulation of RNA biosynthetic process
H1I67_08555	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H1I67_08565	COG2188	Transcriptional regulator
H1I67_08580	COG4521	taurine ABC transporter
H1I67_08585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I67_08605	COG0477	Major facilitator Superfamily
H1I67_08615	COG1027	Aspartate ammonia-lyase
H1I67_08630	COG0583	DNA-binding transcription factor activity
H1I67_08635	COG0583	DNA-binding transcription factor activity
H1I67_08640	COG0183	Belongs to the thiolase family
H1I67_08645	COG2031	fatty acid transporter
H1I67_08650	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1I67_08660	COG0583	DNA-binding transcription factor activity
H1I67_08670	COG2610	gluconate transmembrane transporter activity
H1I67_08675	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_08685	COG2207	Transcriptional regulator
H1I67_08700	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_08725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1I67_08725	COG0543	2 iron, 2 sulfur cluster binding
H1I67_08730	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I67_08735	COG4638	Rieske (2fe-2S)
H1I67_08745	COG0725	ABC transporter, periplasmic molybdate-binding protein
H1I67_08750	COG4149	molybdate abc transporter
H1I67_08755	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H1I67_08760	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_08765	COG1535	isochorismatase
H1I67_08765	COG3433	isochorismatase activity
H1I67_08830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1I67_08845	COG0753	catalase activity
H1I67_08855	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H1I67_08885	COG3539	Fimbrial protein
H1I67_08905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1I67_08925	COG2072	flavoprotein involved in K transport
H1I67_08935	COG1538	Outer membrane efflux protein
H1I67_08940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1I67_08945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I67_08950	COG0745	RESPONSE REGULATOR receiver
H1I67_08955	COG2205	protein histidine kinase activity
H1I67_08965	COG2207	Transcriptional regulator
H1I67_08980	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_09030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H1I67_09145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I67_09165	COG1120	ATPase activity
H1I67_09170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1I67_09180	COG1064	alcohol dehydrogenase
H1I67_09195	COG2207	Transcriptional regulator
H1I67_09200	COG2084	Dehydrogenase
H1I67_09210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1I67_09215	COG0583	DNA-binding transcription factor activity
H1I67_09225	COG0129	dihydroxy-acid dehydratase activity
H1I67_09245	COG1566	PFAM secretion protein HlyD family protein
H1I67_09265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1I67_09295	COG0583	DNA-binding transcription factor activity
H1I67_09310	COG2188	Transcriptional regulator
H1I67_09345	COG2831	hemolysin activation secretion protein
H1I67_09360	COG1473	amidohydrolase
H1I67_09370	COG0475	glutathione-regulated potassium exporter activity
H1I67_09370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I67_09380	COG0583	DNA-binding transcription factor activity
H1I67_09385	COG1335	isochorismatase
H1I67_09395	COG1309	transcriptional regulator
H1I67_09425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H1I67_09435	COG1902	pentaerythritol trinitrate reductase activity
H1I67_09435	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I67_09440	COG1846	Transcriptional regulator
H1I67_09460	COG0753	catalase activity
H1I67_09475	COG1012	belongs to the aldehyde dehydrogenase family
H1I67_09490	COG3162	membrane
H1I67_09500	COG3829	transcription factor binding
H1I67_09505	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_09510	COG1960	acyl-CoA dehydrogenase activity
H1I67_09555	COG2186	Transcriptional regulator
H1I67_09565	COG0583	DNA-binding transcription factor activity
H1I67_09570	COG4948	Mandelate Racemase Muconate Lactonizing
H1I67_09575	COG4829	muconolactone delta-isomerase
H1I67_09595	COG0183	Belongs to the thiolase family
H1I67_09600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I67_09610	COG1012	belongs to the aldehyde dehydrogenase family
H1I67_09620	COG3733	amine oxidase
H1I67_09630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I67_09640	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_09650	COG4638	Rieske (2fe-2S)
H1I67_09670	COG0154	amidase activity
H1I67_09680	COG2814	Major facilitator Superfamily
H1I67_09705	COG1960	acyl-CoA dehydrogenase activity
H1I67_09710	COG0583	DNA-binding transcription factor activity
H1I67_09715	COG1414	Transcriptional regulator
H1I67_09730	COG2391	methyltransferase activity
H1I67_09740	COG4993	Dehydrogenase
H1I67_09745	COG3659	wide pore channel activity
H1I67_09750	COG3420	alginic acid biosynthetic process
H1I67_09755	COG0710	3-dehydroquinate dehydratase activity
H1I67_09760	COG3485	protocatechuate 3,4-dioxygenase
H1I67_09765	COG3485	protocatechuate 3,4-dioxygenase
H1I67_09770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1I67_09775	COG2271	Major facilitator Superfamily
H1I67_09780	COG0596	Alpha beta hydrolase
H1I67_09785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H1I67_09790	COG0183	Belongs to the thiolase family
H1I67_09810	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H1I67_09815	COG2323	membrane
H1I67_09860	COG1902	pentaerythritol trinitrate reductase activity
H1I67_09860	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I67_09885	COG0542	response to heat
H1I67_09890	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1I67_09920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1I67_09925	COG0569	domain protein
H1I67_09930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H1I67_09945	COG4774	siderophore transport
H1I67_09950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1I67_09960	COG1585	Membrane protein implicated in regulation of membrane protease activity
H1I67_09975	COG1294	oxidase, subunit
H1I67_09980	COG4890	Cyd operon protein YbgT
H1I67_09995	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H1I67_10005	COG0552	protein localization to endoplasmic reticulum
H1I67_10030	COG0517	IMP dehydrogenase activity
H1I67_10030	COG0516	GMP reductase activity
H1I67_10035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1I67_10040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H1I67_10050	COG0583	DNA-binding transcription factor activity
H1I67_10055	COG0024	Methionine aminopeptidase
H1I67_10085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1I67_10085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I67_10090	COG1105	Belongs to the carbohydrate kinase PfkB family
H1I67_10095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I67_10095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1I67_10095	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H1I67_10115	COG3300	MHYT domain
H1I67_10115	COG5001	Diguanylate cyclase
H1I67_10130	COG2135	peptidase activity
H1I67_10135	COG0659	secondary active sulfate transmembrane transporter activity
H1I67_10150	COG1113	amino acid transport
H1I67_10160	COG1522	sequence-specific DNA binding
H1I67_10185	COG1011	Hydrolase
H1I67_10190	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H1I67_10200	COG2137	regulation of response to DNA damage stimulus
H1I67_10215	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I67_10250	COG0575	Belongs to the CDS family
H1I67_10255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H1I67_10275	COG3852	Histidine kinase
H1I67_10280	COG2204	response regulator
H1I67_10335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I67_10340	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H1I67_10360	COG0697	spore germination
H1I67_10365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1I67_10375	COG0303	'Molybdopterin
H1I67_10380	COG0521	Mo-molybdopterin cofactor biosynthetic process
H1I67_10380	COG0315	cyclic pyranopterin monophosphate synthase activity
H1I67_10395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H1I67_10400	COG0243	molybdopterin cofactor binding
H1I67_10410	COG0243	molybdopterin cofactor binding
H1I67_10415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I67_10420	COG2146	nitrite reductase [NAD(P)H] activity
H1I67_10420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I67_10430	COG0745	RESPONSE REGULATOR receiver
H1I67_10455	COG0511	ligase activity, forming carbon-carbon bonds
H1I67_10470	COG2814	Major facilitator Superfamily
H1I67_10685	COG5410	chromosome segregation
H1I67_10855	COG0069	glutamate synthase activity
H1I67_10875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H1I67_10885	COG1454	alcohol dehydrogenase
H1I67_10890	COG0824	Thioesterase
H1I67_10900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H1I67_10915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I67_10920	COG2030	dehydratase
H1I67_10930	COG0183	Belongs to the thiolase family
H1I67_10940	COG0583	DNA-binding transcription factor activity
H1I67_10945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H1I67_10955	COG1522	sequence-specific DNA binding
H1I67_10970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H1I67_10995	COG0589	response to stress
H1I67_11000	COG0488	(ABC) transporter
H1I67_11020	COG4773	Receptor
H1I67_11055	COG0668	transmembrane transport
H1I67_11065	COG1309	transcriptional regulator
H1I67_11080	COG1605	Chorismate mutase
H1I67_11110	COG0308	aminopeptidase N
H1I67_11130	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H1I67_11140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I67_11145	COG1454	alcohol dehydrogenase
H1I67_11165	COG0531	amino acid
H1I67_11170	COG4303	Ethanolamine ammonia lyase large subunit
H1I67_11175	COG4302	ethanolamine ammonia-lyase activity
H1I67_11180	COG0519	Catalyzes the synthesis of GMP from XMP
H1I67_11180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I67_11185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I67_11195	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1I67_11215	COG1923	regulation of RNA biosynthetic process
H1I67_11225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H1I67_11230	COG0802	atpase or kinase
H1I67_11250	COG1187	pseudouridine synthase activity
H1I67_11265	COG0583	DNA-binding transcription factor activity
H1I67_11280	COG2814	Major facilitator Superfamily
H1I67_11285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1I67_11310	COG0729	surface antigen
H1I67_11330	COG0174	glutamine synthetase
H1I67_11335	COG0745	RESPONSE REGULATOR receiver
H1I67_11340	COG2205	protein histidine kinase activity
H1I67_11350	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H1I67_11355	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H1I67_11380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I67_11385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I67_11390	COG1960	acyl-CoA dehydrogenase activity
H1I67_11405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I67_11410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I67_11430	COG0583	DNA-binding transcription factor activity
H1I67_11445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I67_11455	COG3658	cytochrome
H1I67_11460	COG1215	transferase activity, transferring glycosyl groups
H1I67_11465	COG1649	PFAM Uncharacterised BCR, COG1649
H1I67_11465	COG0726	polysaccharide deacetylase
H1I67_11490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H1I67_11495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1I67_11505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H1I67_11530	COG0305	Participates in initiation and elongation during chromosome replication
H1I67_11535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1I67_11545	COG1305	Transglutaminase-like
H1I67_11555	COG2308	Evidence 4 Homologs of previously reported genes of
H1I67_11585	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H1I67_11590	COG0138	bifunctional purine biosynthesis protein purh
H1I67_11595	COG0151	Belongs to the GarS family
H1I67_11600	COG1464	Belongs to the NlpA lipoprotein family
H1I67_11605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1I67_11610	COG2011	ABC-type metal ion transport system permease component
H1I67_11615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I67_11625	COG1301	dicarboxylic acid transport
H1I67_11660	COG1116	anion transmembrane transporter activity
H1I67_11665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1I67_11675	COG0864	Transcriptional regulator
H1I67_11695	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1I67_11700	COG0439	Biotin carboxylase
H1I67_11715	COG1063	alcohol dehydrogenase
H1I67_11725	COG1309	transcriptional regulator
H1I67_11745	COG0038	chloride channel
H1I67_11750	COG4770	biotin carboxylase activity
H1I67_11770	COG1914	H( )-stimulated, divalent metal cation uptake system
H1I67_11775	COG0583	DNA-binding transcription factor activity
H1I67_11825	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1I67_11865	COG5006	permease, DMT superfamily
H1I67_11870	COG1522	sequence-specific DNA binding
H1I67_11885	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1I67_11895	COG4122	O-methyltransferase activity
H1I67_11925	COG1538	Outer membrane efflux protein
H1I67_11930	COG1137	ATPase activity
H1I67_11935	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H1I67_11945	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H1I67_11950	COG0517	IMP dehydrogenase activity
H1I67_11950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H1I67_11985	COG2814	Major facilitator Superfamily
H1I67_12020	COG1278	Cold shock
H1I67_12025	COG1280	lysine exporter protein (LysE YggA)
H1I67_12055	COG1570	exodeoxyribonuclease VII activity
H1I67_12105	COG0583	DNA-binding transcription factor activity
H1I67_12110	COG4638	Rieske (2fe-2S)
H1I67_12115	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H1I67_12120	COG0543	2 iron, 2 sulfur cluster binding
H1I67_12120	COG0633	Ferredoxin
H1I67_12125	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_12130	COG3135	benzoate transporter
H1I67_12135	COG2814	Major facilitator Superfamily
H1I67_12150	COG1643	Atp-dependent helicase
H1I67_12155	COG0450	alkyl hydroperoxide reductase
H1I67_12165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H1I67_12195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H1I67_12200	COG0625	glutathione transferase activity
H1I67_12210	COG2885	chlorophyll binding
H1I67_12245	COG0542	response to heat
H1I67_12260	COG1765	OsmC-like protein
H1I67_12275	COG0667	Aldo Keto reductase
H1I67_12290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H1I67_12300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H1I67_12310	COG0527	aspartate kinase activity
H1I67_12320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H1I67_12330	COG3038	cytochrome b561
H1I67_12335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H1I67_12340	COG2252	PERMEase
H1I67_12350	COG2072	flavoprotein involved in K transport
H1I67_12375	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I67_12375	COG1902	pentaerythritol trinitrate reductase activity
H1I67_12385	COG5001	Diguanylate cyclase
H1I67_12385	COG4251	negative regulation of phosphorylation
H1I67_12385	COG3706	GGDEF domain
H1I67_12385	COG2203	Gaf domain
H1I67_12395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I67_12415	COG4172	Belongs to the ABC transporter superfamily
H1I67_12420	COG4239	(ABC) transporter, permease
H1I67_12425	COG4174	ABC transporter (Permease)
H1I67_12435	COG0741	lytic transglycosylase activity
H1I67_12435	COG1388	LysM domain
H1I67_12435	COG1388	LysM domain
H1I67_12435	COG0741	lytic transglycosylase activity
H1I67_12440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I67_12480	COG0583	DNA-binding transcription factor activity
H1I67_12485	COG1279	arginine transmembrane transporter activity
H1I67_12505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I67_12510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I67_12515	COG0006	proline dipeptidase activity
H1I67_12595	COG0739	heme binding
H1I67_12925	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H1I67_12950	COG3384	dioxygenase
H1I67_12960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1I67_12965	COG2878	Part of a membrane complex involved in electron transport
H1I67_12970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H1I67_12995	COG0768	penicillin binding
H1I67_13000	COG0742	ribosomal rna small subunit methyltransferase
H1I67_13015	COG0830	nickel cation binding
H1I67_13065	COG1253	flavin adenine dinucleotide binding
H1I67_13070	COG2851	Citrate transporter
H1I67_13125	COG1773	rubredoxin
H1I67_13130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1I67_13140	COG0583	DNA-binding transcription factor activity
H1I67_13165	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H1I67_13170	COG4181	ATPase activity
H1I67_13215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H1I67_13235	COG0306	phosphate transporter
H1I67_13245	COG3958	Transketolase
H1I67_13250	COG3959	Transketolase, thiamine diphosphate binding domain
H1I67_13255	COG2271	Major facilitator Superfamily
H1I67_13260	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_13265	COG0583	DNA-binding transcription factor activity
H1I67_13280	COG2223	nitrite transmembrane transporter activity
H1I67_13285	COG2207	Transcriptional regulator
H1I67_13290	COG2066	Belongs to the glutaminase family
H1I67_13295	COG0242	peptide deformylase activity
H1I67_13300	COG0477	Major facilitator Superfamily
H1I67_13310	COG0028	Belongs to the TPP enzyme family
H1I67_13325	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_13330	COG2267	carboxylic ester hydrolase activity
H1I67_13340	COG2271	Major facilitator Superfamily
H1I67_13345	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1I67_13355	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_13375	COG1414	Transcriptional regulator
H1I67_13390	COG1024	Enoyl-CoA hydratase
H1I67_13400	COG1215	transferase activity, transferring glycosyl groups
H1I67_13405	COG0726	polysaccharide deacetylase
H1I67_13405	COG1649	PFAM Uncharacterised BCR, COG1649
H1I67_13415	COG4681	YaeQ
H1I67_13425	COG0523	cobalamin synthesis protein
H1I67_13435	COG1607	acyl-coa hydrolase
H1I67_13445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I67_13450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1I67_13455	COG1309	transcriptional regulator
H1I67_13480	COG2040	homocysteine
H1I67_13485	COG0531	amino acid
H1I67_13540	COG1595	DNA-templated transcription, initiation
H1I67_13550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I67_13555	COG0477	Major facilitator Superfamily
H1I67_13575	COG0084	hydrolase, TatD family'
H1I67_13610	COG0629	single-stranded DNA binding
H1I67_13665	COG0582	viral genome integration into host DNA
H1I67_13760	COG0592	DNA-directed DNA polymerase activity
H1I67_13800	COG2026	Addiction module toxin, RelE StbE family
H1I67_13995	COG1484	DNA-dependent DNA replication
H1I67_14085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1I67_14155	COG0405	Gamma-glutamyltransferase
H1I67_14160	COG2814	Major facilitator Superfamily
H1I67_14170	COG2050	protein possibly involved in aromatic compounds catabolism
H1I67_14185	COG1090	epimerase
H1I67_14205	COG0420	3'-5' exonuclease activity
H1I67_14230	COG0735	belongs to the Fur family
H1I67_14235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1I67_14255	COG0121	glutamine amidotransferase
H1I67_14270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I67_14280	COG0210	DNA helicase
H1I67_14285	COG2885	chlorophyll binding
H1I67_14290	COG0204	Acyl-transferase
H1I67_14305	COG2894	cell division
H1I67_14325	COG1280	lysine exporter protein (LysE YggA)
H1I67_14335	COG0492	ferredoxin-NADP+ reductase activity
H1I67_14340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H1I67_14350	COG0456	acetyltransferase
H1I67_14395	COG1981	membrane
H1I67_14410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I67_14410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H1I67_14430	COG1012	belongs to the aldehyde dehydrogenase family
H1I67_14440	COG0657	acetylesterase activity
H1I67_14450	COG0473	3-isopropylmalate dehydrogenase activity
H1I67_14455	COG0583	DNA-binding transcription factor activity
H1I67_14475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1I67_14500	COG0564	pseudouridine synthase activity
H1I67_14510	COG0358	DNA primase activity
H1I67_14525	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H1I67_14555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1I67_14585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1I67_14595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1I67_14595	COG0351	phosphomethylpyrimidine kinase
H1I67_14595	COG0352	thiamine-phosphate diphosphorylase activity
H1I67_14600	COG1652	LysM domain
H1I67_14625	COG1399	metal-binding, possibly nucleic acid-binding protein
H1I67_14630	COG3101	peptidyl-lysine hydroxylation
H1I67_14635	COG0009	L-threonylcarbamoyladenylate synthase
H1I67_14640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H1I67_14645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H1I67_14660	COG4106	trans-aconitate 2-methyltransferase activity
H1I67_14675	COG0596	Alpha beta hydrolase
H1I67_14675	COG2226	methyltransferase
H1I67_14675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I67_14680	COG1877	trehalose-phosphatase activity
H1I67_14685	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H1I67_14690	COG2223	nitrite transmembrane transporter activity
H1I67_14720	COG0730	response to heat
H1I67_14735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H1I67_14745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I67_14795	COG0489	protein tyrosine kinase activity
H1I67_14805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I67_14805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I67_14835	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H1I67_14840	COG2081	HI0933 family
H1I67_14850	COG0668	transmembrane transport
H1I67_14870	COG0583	DNA-binding transcription factor activity
H1I67_14890	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1I67_14895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I67_14925	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H1I67_14965	COG0745	RESPONSE REGULATOR receiver
H1I67_14985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H1I67_14995	COG2205	protein histidine kinase activity
H1I67_15065	COG4993	Dehydrogenase
H1I67_15090	COG0384	phenazine biosynthesis protein PhzF
H1I67_15110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1I67_15125	COG0583	DNA-binding transcription factor activity
H1I67_15155	COG0583	DNA-binding transcription factor activity
H1I67_15170	COG0583	DNA-binding transcription factor activity
H1I67_15175	COG1053	succinate dehydrogenase
H1I67_15185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H1I67_15190	COG2814	Major facilitator Superfamily
H1I67_15195	COG1960	acyl-CoA dehydrogenase activity
H1I67_15200	COG0583	DNA-binding transcription factor activity
H1I67_15205	COG1063	alcohol dehydrogenase
H1I67_15235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H1I67_15240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H1I67_15245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I67_15265	COG2132	Multicopper oxidase
H1I67_15275	COG0561	phosphatase activity
H1I67_15280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H1I67_15305	COG1214	PFAM Peptidase M22, glycoprotease
H1I67_15360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1I67_15370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H1I67_15375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H1I67_15380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H1I67_15440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1I67_15450	COG1846	Transcriptional regulator
H1I67_15455	COG1764	response to oxidative stress
H1I67_15505	COG0037	tRNA processing
H1I67_15515	COG0248	Ppx GppA phosphatase
H1I67_15545	COG0072	phenylalanine-tRNA ligase activity
H1I67_15585	COG1238	metal cluster binding
H1I67_15590	COG0625	glutathione transferase activity
H1I67_15605	COG0318	PFAM AMP-dependent synthetase and ligase
H1I67_15610	COG3028	Belongs to the UPF0307 family
H1I67_15615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1I67_15635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H1I67_15645	COG1555	photosystem II stabilization
H1I67_15660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1I67_15680	COG0784	Response regulator, receiver
H1I67_15680	COG2205	protein histidine kinase activity
H1I67_15680	COG5002	protein histidine kinase activity
H1I67_15685	COG1024	Enoyl-CoA hydratase
H1I67_15690	COG2084	Dehydrogenase
H1I67_15695	COG3622	Belongs to the hyi family
H1I67_15725	COG0697	spore germination
H1I67_15735	COG2814	Major facilitator Superfamily
H1I67_15740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1I67_15750	COG0583	DNA-binding transcription factor activity
H1I67_15760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H1I67_15775	COG0084	hydrolase, TatD family'
H1I67_15790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H1I67_15820	COG0440	acetolactate synthase activity
H1I67_15825	COG0028	Belongs to the TPP enzyme family
H1I67_15850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1I67_15855	COG0577	efflux transmembrane transporter activity
H1I67_15855	COG1136	(ABC) transporter
H1I67_15860	COG1538	Outer membrane efflux protein
H1I67_15875	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H1I67_15880	COG1162	GTPase activity
H1I67_15890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1I67_15910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1I67_15915	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_15955	COG2986	histidine ammonia-lyase
H1I67_15970	COG0318	PFAM AMP-dependent synthetase and ligase
H1I67_15980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1I67_16025	COG1426	Protein conserved in bacteria
H1I67_16060	COG0793	Belongs to the peptidase S41A family
H1I67_16075	COG2267	carboxylic ester hydrolase activity
H1I67_16085	COG1012	belongs to the aldehyde dehydrogenase family
H1I67_16090	COG3265	gluconokinase activity
H1I67_16100	COG0800	Aldolase
H1I67_16115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H1I67_16120	COG0280	phosphate acetyltransferase
H1I67_16120	COG0857	belongs to the CobB CobQ family
H1I67_16125	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I67_16125	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H1I67_16145	COG0740	serine-type endopeptidase activity
H1I67_16155	COG4774	siderophore transport
H1I67_16165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1I67_16175	COG2813	Specifically methylates the guanine in position
H1I67_16175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1I67_16275	COG0788	formyltetrahydrofolate deformylase activity
H1I67_16300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I67_16300	COG4651	solute:proton antiporter activity
H1I67_16320	COG0724	RNA recognition motif
H1I67_16325	COG0210	DNA helicase
H1I67_16350	COG1733	regulation of RNA biosynthetic process
H1I67_16360	COG2900	Belongs to the SlyX family
H1I67_16365	COG0488	(ABC) transporter
H1I67_16370	COG1280	lysine exporter protein (LysE YggA)
H1I67_16375	COG1560	Kdo2-lipid A biosynthetic process
H1I67_16385	COG1301	dicarboxylic acid transport
H1I67_16505	COG0583	DNA-binding transcription factor activity
H1I67_16515	COG0625	glutathione transferase activity
H1I67_16520	COG2378	regulation of single-species biofilm formation
H1I67_16525	COG0546	phosphoglycolate phosphatase activity
H1I67_16535	COG1530	ribonuclease E activity
H1I67_16540	COG0318	PFAM AMP-dependent synthetase and ligase
H1I67_16555	COG0583	DNA-binding transcription factor activity
H1I67_16560	COG4221	oxidoreductase activity
H1I67_16565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1I67_16575	COG0534	Mate efflux family protein
H1I67_16590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H1I67_16630	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H1I67_16635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1I67_16650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1I67_16660	COG0644	oxidoreductase
H1I67_16660	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H1I67_16665	COG0425	Belongs to the sulfur carrier protein TusA family
H1I67_16670	COG4535	Mg2 and Co2 transporter CorC
H1I67_16680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1I67_16700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H1I67_16705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1I67_16705	COG0475	glutathione-regulated potassium exporter activity
H1I67_16710	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H1I67_16720	COG0484	heat shock protein binding
H1I67_16725	COG0789	Transcriptional regulator
H1I67_16730	COG0598	Magnesium transport protein CorA
H1I67_16745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1I67_16750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1I67_16755	COG1074	ATP-dependent DNA helicase activity
H1I67_16760	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H1I67_16780	COG2226	methyltransferase
H1I67_16795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1I67_16800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H1I67_16815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1I67_16815	COG2111	Na H antiporter
H1I67_16820	COG1006	Multisubunit Na H antiporter MnhC subunit
H1I67_16825	COG0651	ATP synthesis coupled electron transport
H1I67_16830	COG1863	multisubunit Na H antiporter MnhE subunit
H1I67_16835	COG2212	antiporter activity
H1I67_16840	COG1320	monovalent cation:proton antiporter activity
H1I67_16855	COG0195	Participates in both transcription termination and antitermination
H1I67_16905	COG0237	dephospho-CoA kinase activity
H1I67_16915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1I67_16930	COG0497	DNA recombination
H1I67_16940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H1I67_16970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1I67_16970	COG2169	Transcriptional regulator
H1I67_16975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H1I67_17040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H1I67_17070	COG2056	Na+-H+ antiporter family
H1I67_17075	COG0596	Alpha beta hydrolase
H1I67_17170	COG0546	phosphoglycolate phosphatase activity
H1I67_17175	COG1716	ATPase activity
H1I67_17220	COG0181	hydroxymethylbilane synthase activity
H1I67_17230	COG3275	phosphorelay sensor kinase activity
H1I67_17250	COG1538	Outer membrane efflux protein
H1I67_17255	COG0697	spore germination
H1I67_17285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H1I67_17290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1I67_17320	COG4974	Belongs to the 'phage' integrase family
H1I67_17325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I67_17335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H1I67_17345	COG2197	response regulator
H1I67_17360	COG0793	Belongs to the peptidase S41A family
H1I67_17365	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H1I67_17370	COG0795	lipopolysaccharide-transporting ATPase activity
H1I67_17410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I67_17410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1I67_17420	COG0004	ammonium transporteR
H1I67_17425	COG0347	Belongs to the P(II) protein family
H1I67_17435	COG0606	chelatase, subunit chli
H1I67_17505	COG1061	Type III restriction enzyme res subunit
H1I67_17520	COG0659	secondary active sulfate transmembrane transporter activity
H1I67_17525	COG0589	response to stress
H1I67_17555	COG0606	chelatase, subunit chli
H1I67_17570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1I67_17585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H1I67_17600	COG0318	PFAM AMP-dependent synthetase and ligase
H1I67_17610	COG0477	Major facilitator Superfamily
H1I67_17615	COG2860	membrane
H1I67_17625	COG1253	flavin adenine dinucleotide binding
H1I67_17645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1I67_17680	COG0655	NAD(P)H dehydrogenase (quinone) activity
H1I67_17690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H1I67_17725	COG1309	transcriptional regulator
H1I67_17760	COG0758	DNA mediated transformation
H1I67_17770	COG0697	spore germination
H1I67_17775	COG1309	transcriptional regulator
H1I67_17790	COG0386	Belongs to the glutathione peroxidase family
H1I67_17865	COG1061	Type III restriction enzyme res subunit
H1I67_17875	COG1192	Involved in chromosome partitioning
H1I67_17880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1I67_17890	COG1061	Type III restriction enzyme res subunit
H1I67_17905	COG1121	(ABC) transporter
H1I67_17910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1I67_17915	COG1280	lysine exporter protein (LysE YggA)
H1I67_17920	COG2837	iron assimilation
H1I67_17930	COG0281	malic enzyme
H1I67_17975	COG0519	Catalyzes the synthesis of GMP from XMP
H1I67_17975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1I67_17980	COG4399	Belongs to the UPF0754 family
H1I67_17985	COG2259	Doxx family
H1I67_17990	COG0586	Pfam SNARE associated Golgi protein
H1I67_18005	COG1192	Involved in chromosome partitioning
H1I67_18015	COG0271	Belongs to the BolA IbaG family
H1I67_18035	COG2267	carboxylic ester hydrolase activity
H1I67_18055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1I67_18055	COG0300	oxidoreductase activity
H1I67_18055	COG4221	oxidoreductase activity
H1I67_18055	COG3321	synthase
H1I67_18060	COG1960	acyl-CoA dehydrogenase activity
H1I67_18070	COG2197	response regulator
H1I67_18080	COG3916	Acyl-homoserine-lactone synthase
H1I67_18085	COG0477	Major facilitator Superfamily
H1I67_18090	COG1024	Enoyl-CoA hydratase
H1I67_18095	COG1024	Enoyl-CoA hydratase
H1I67_18100	COG1960	acyl-CoA dehydrogenase activity
H1I67_18105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1I67_18125	COG1113	amino acid transport
H1I67_18130	COG1113	amino acid transport
H1I67_18135	COG0251	oxidation-reduction process
H1I67_18175	COG0564	pseudouridine synthase activity
H1I67_18235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H1I67_18250	COG1802	Transcriptional regulator
H1I67_18260	COG1448	Aminotransferase
H1I67_18265	COG0277	FAD linked oxidase domain protein
H1I67_18275	COG2186	Transcriptional regulator
H1I67_18285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1I67_18290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1I67_18305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H1I67_18315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H1I67_18325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1I67_18330	COG0438	transferase activity, transferring glycosyl groups
H1I67_18350	COG1216	Glycosyl transferase, family 2
H1I67_18355	COG5039	Polysaccharide pyruvyl transferase
H1I67_18365	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H1I67_18370	COG1596	polysaccharide export
H1I67_18395	COG0728	peptidoglycan biosynthetic process
H1I67_18400	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1I67_18455	COG0546	phosphoglycolate phosphatase activity
H1I67_18460	COG1028	Short-chain dehydrogenase reductase Sdr
H1I67_18480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I67_18485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1I67_18490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1I67_18495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1I67_18500	COG1116	anion transmembrane transporter activity
H1I67_18505	COG1309	transcriptional regulator
H1I67_18510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1I67_18520	COG0196	riboflavin kinase activity
H1I67_18525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H1I67_18535	COG1047	Peptidyl-prolyl cis-trans
H1I67_18575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H1I67_18630	COG2951	lytic endotransglycosylase activity
H1I67_18635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H1I67_18650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H1I67_18660	COG0671	phosphoesterase, PA-phosphatase related
H1I67_18665	COG0861	Integral membrane protein TerC family
H1I67_18685	COG0402	S-adenosylhomocysteine deaminase activity
H1I67_18700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1I67_18705	COG1230	cation diffusion facilitator family transporter
H1I67_18720	COG0706	membrane insertase activity