locus-tag	class	description
N4T40_00125	COG5410	chromosome segregation
N4T40_00285	COG0527	aspartate kinase activity
N4T40_00295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N4T40_00305	COG3038	cytochrome b561
N4T40_00310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N4T40_00315	COG2252	PERMEase
N4T40_00325	COG2072	flavoprotein involved in K transport
N4T40_00340	COG1741	Belongs to the pirin family
N4T40_00345	COG1309	transcriptional regulator
N4T40_00355	COG0300	oxidoreductase activity
N4T40_00365	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
N4T40_00410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N4T40_00425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4T40_00465	COG0582	viral genome integration into host DNA
N4T40_00475	COG0446	pyridine nucleotide-disulphide oxidoreductase
N4T40_00475	COG1902	pentaerythritol trinitrate reductase activity
N4T40_00495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N4T40_00515	COG4172	Belongs to the ABC transporter superfamily
N4T40_00520	COG4239	(ABC) transporter, permease
N4T40_00535	COG1388	LysM domain
N4T40_00535	COG0741	lytic transglycosylase activity
N4T40_00535	COG1388	LysM domain
N4T40_00535	COG0741	lytic transglycosylase activity
N4T40_00540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N4T40_00595	COG0583	DNA-binding transcription factor activity
N4T40_00600	COG1279	arginine transmembrane transporter activity
N4T40_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N4T40_00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N4T40_00630	COG0006	proline dipeptidase activity
N4T40_00670	COG2194	sulfuric ester hydrolase activity
N4T40_00715	COG0739	heme binding
N4T40_00715	COG0741	lytic transglycosylase activity
N4T40_00715	COG1196	nuclear chromosome segregation
N4T40_00825	COG5410	chromosome segregation
N4T40_01010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N4T40_01040	COG3384	dioxygenase
N4T40_01050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N4T40_01055	COG2878	Part of a membrane complex involved in electron transport
N4T40_01060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N4T40_01085	COG0768	penicillin binding
N4T40_01090	COG0742	ribosomal rna small subunit methyltransferase
N4T40_01105	COG0830	nickel cation binding
N4T40_01115	COG0804	urea catabolic process
N4T40_01160	COG1253	flavin adenine dinucleotide binding
N4T40_01165	COG2851	Citrate transporter
N4T40_01220	COG1773	rubredoxin
N4T40_01225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N4T40_01235	COG0583	DNA-binding transcription factor activity
N4T40_01270	COG4181	ATPase activity
N4T40_01315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N4T40_01335	COG0306	phosphate transporter
N4T40_01345	COG3958	Transketolase
N4T40_01350	COG3959	Transketolase, thiamine diphosphate binding domain
N4T40_01355	COG2271	Major facilitator Superfamily
N4T40_01360	COG1028	Short-chain dehydrogenase reductase Sdr
N4T40_01365	COG0583	DNA-binding transcription factor activity
N4T40_01380	COG2223	nitrite transmembrane transporter activity
N4T40_01385	COG2207	Transcriptional regulator
N4T40_01390	COG2066	Belongs to the glutaminase family
N4T40_01395	COG0242	peptide deformylase activity
N4T40_01400	COG0477	Major facilitator Superfamily
N4T40_01410	COG0028	Belongs to the TPP enzyme family
N4T40_01425	COG1028	Short-chain dehydrogenase reductase Sdr
N4T40_01440	COG2271	Major facilitator Superfamily
N4T40_01455	COG1028	Short-chain dehydrogenase reductase Sdr
N4T40_01475	COG1414	Transcriptional regulator
N4T40_01490	COG1024	Enoyl-CoA hydratase
N4T40_01500	COG1215	transferase activity, transferring glycosyl groups
N4T40_01505	COG0726	polysaccharide deacetylase
N4T40_01505	COG1649	PFAM Uncharacterised BCR, COG1649
N4T40_01515	COG4681	YaeQ
N4T40_01525	COG0523	cobalamin synthesis protein
N4T40_01535	COG1607	acyl-coa hydrolase
N4T40_01545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N4T40_01550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N4T40_01555	COG1309	transcriptional regulator
N4T40_01585	COG0531	amino acid
N4T40_01640	COG1595	DNA-templated transcription, initiation
N4T40_01650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N4T40_01655	COG0477	Major facilitator Superfamily
N4T40_01665	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
N4T40_01735	COG0405	Gamma-glutamyltransferase
N4T40_01740	COG2814	Major facilitator Superfamily
N4T40_01750	COG2050	protein possibly involved in aromatic compounds catabolism
N4T40_01765	COG1090	epimerase
N4T40_01785	COG0420	3'-5' exonuclease activity
N4T40_01810	COG0735	belongs to the Fur family
N4T40_01815	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N4T40_01835	COG0121	glutamine amidotransferase
N4T40_01850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N4T40_01860	COG0210	DNA helicase
N4T40_01865	COG2885	chlorophyll binding
N4T40_01870	COG0204	Acyl-transferase
N4T40_01885	COG2894	cell division
N4T40_01900	COG1280	lysine exporter protein (LysE YggA)
N4T40_01905	COG1674	ftsk spoiiie
N4T40_01910	COG0492	ferredoxin-NADP+ reductase activity
N4T40_01915	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N4T40_01925	COG0456	acetyltransferase
N4T40_01970	COG1981	membrane
N4T40_01985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N4T40_01985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N4T40_02005	COG1012	belongs to the aldehyde dehydrogenase family
N4T40_02015	COG0657	acetylesterase activity
N4T40_02025	COG0473	3-isopropylmalate dehydrogenase activity
N4T40_02030	COG0583	DNA-binding transcription factor activity
N4T40_02050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N4T40_02060	COG0582	viral genome integration into host DNA
N4T40_02140	COG0739	heme binding
N4T40_02150	COG3561	AntA/AntB antirepressor
N4T40_02280	COG5410	chromosome segregation
N4T40_02370	COG0305	Participates in initiation and elongation during chromosome replication
N4T40_02400	COG3620	sequence-specific DNA binding
N4T40_02430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N4T40_02480	COG0564	pseudouridine synthase activity
N4T40_02490	COG0358	DNA primase activity
N4T40_02505	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N4T40_02535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N4T40_02565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N4T40_02575	COG0351	phosphomethylpyrimidine kinase
N4T40_02575	COG0352	thiamine-phosphate diphosphorylase activity
N4T40_02575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N4T40_02580	COG1652	LysM domain
N4T40_02605	COG1399	metal-binding, possibly nucleic acid-binding protein
N4T40_02610	COG3101	peptidyl-lysine hydroxylation
N4T40_02615	COG0009	L-threonylcarbamoyladenylate synthase
N4T40_02620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N4T40_02625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N4T40_02640	COG4106	trans-aconitate 2-methyltransferase activity
N4T40_02655	COG0596	Alpha beta hydrolase
N4T40_02655	COG2226	methyltransferase
N4T40_02655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N4T40_02660	COG1877	trehalose-phosphatase activity
N4T40_02665	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
N4T40_02670	COG2223	nitrite transmembrane transporter activity
N4T40_02690	COG1196	nuclear chromosome segregation
N4T40_02700	COG0730	response to heat
N4T40_02715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N4T40_02725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N4T40_02780	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_02805	COG0464	growth
N4T40_02825	COG2207	Transcriptional regulator
N4T40_02850	COG2249	NAD(P)H dehydrogenase (quinone) activity
N4T40_02860	COG0560	Phosphoserine phosphatase
N4T40_02870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N4T40_02880	COG1530	ribonuclease E activity
N4T40_02885	COG0424	maF-like protein
N4T40_02890	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N4T40_02895	COG1792	Involved in formation and maintenance of cell shape
N4T40_02900	COG1077	Cell shape determining protein MreB Mrl
N4T40_02905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N4T40_02915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N4T40_02940	COG3590	peptidase
N4T40_02945	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
N4T40_02950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N4T40_02955	COG1752	Esterase of the alpha-beta hydrolase superfamily
N4T40_02960	COG1115	amino acid carrier protein
N4T40_02980	COG2814	Major facilitator Superfamily
N4T40_02985	COG1289	transmembrane transporter activity
N4T40_02995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N4T40_03035	COG1376	ErfK ybiS ycfS ynhG family protein
N4T40_03040	COG2832	Protein of unknown function (DUF454)
N4T40_03050	COG5510	response to toxic substance
N4T40_03070	COG0840	transmembrane signaling receptor activity
N4T40_03110	COG3422	double-strand break repair
N4T40_03115	COG2824	Alkylphosphonate utilization operon protein PhnA
N4T40_03120	COG3189	MarR family transcriptional regulator
N4T40_03130	COG0354	folic acid binding
N4T40_03135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N4T40_03145	COG0679	Auxin Efflux Carrier
N4T40_03150	COG1902	pentaerythritol trinitrate reductase activity
N4T40_03155	COG4772	TonB-dependent receptor
N4T40_03160	COG2094	Belongs to the DNA glycosylase MPG family
N4T40_03185	COG1217	gtp-binding protein TYPA
N4T40_03190	COG2233	PERMEase
N4T40_03200	COG0833	amino acid
N4T40_03205	COG1690	Belongs to the RtcB family
N4T40_03215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
N4T40_03215	COG2885	chlorophyll binding
N4T40_03225	COG0183	Belongs to the thiolase family
N4T40_03245	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N4T40_03265	COG2207	Transcriptional regulator
N4T40_03270	COG0183	Belongs to the thiolase family
N4T40_03300	COG1272	protein, Hemolysin III
N4T40_03305	COG0477	Major facilitator Superfamily
N4T40_03320	COG0450	alkyl hydroperoxide reductase
N4T40_03340	COG0285	dihydrofolate synthase activity
N4T40_03385	COG4206	TonB-dependent receptor
N4T40_03390	COG2096	Adenosyltransferase
N4T40_03395	COG0584	glycerophosphoryl diester phosphodiesterase
N4T40_03410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N4T40_03415	COG0745	RESPONSE REGULATOR receiver
N4T40_03420	COG2205	protein histidine kinase activity
N4T40_03430	COG1960	acyl-CoA dehydrogenase activity
N4T40_03435	COG1960	acyl-CoA dehydrogenase activity
N4T40_03495	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_03520	COG0438	transferase activity, transferring glycosyl groups
N4T40_03525	COG0463	Glycosyl transferase, family 2
N4T40_03530	COG0726	polysaccharide deacetylase
N4T40_03550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N4T40_03610	COG1862	Preprotein translocase
N4T40_03620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N4T40_03625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N4T40_03635	COG3781	membrane
N4T40_03650	COG2350	Protein conserved in bacteria
N4T40_03680	COG1607	acyl-coa hydrolase
N4T40_03740	COG2199	diguanylate cyclase activity
N4T40_03750	COG1408	metallophosphoesterase
N4T40_03755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N4T40_03765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N4T40_03785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N4T40_03790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N4T40_03805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N4T40_03815	COG2969	positive regulation of protein catabolic process
N4T40_03835	COG1960	acyl-CoA dehydrogenase activity
N4T40_03840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N4T40_03855	COG1309	transcriptional regulator
N4T40_03860	COG1960	acyl-CoA dehydrogenase activity
N4T40_03905	COG1183	phosphatidylcholine synthase activity
N4T40_03910	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N4T40_03940	COG0741	lytic transglycosylase activity
N4T40_03940	COG0739	heme binding
N4T40_03940	COG1196	nuclear chromosome segregation
N4T40_03950	COG1702	phosphate starvation-inducible protein PhoH
N4T40_03985	COG1295	ribonuclease BN
N4T40_03990	COG0697	spore germination
N4T40_04000	COG0179	Fumarylacetoacetate (FAA) hydrolase
N4T40_04045	COG0557	exoribonuclease II activity
N4T40_04050	COG0339	signal peptide processing
N4T40_04055	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
N4T40_04085	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N4T40_04090	COG1960	acyl-CoA dehydrogenase activity
N4T40_04245	COG0626	cystathionine gamma-synthase activity
N4T40_04250	COG0433	COG0433 Predicted ATPase
N4T40_04260	COG1017	nitric oxide dioxygenase activity
N4T40_04260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4T40_04265	COG1959	2 iron, 2 sulfur cluster binding
N4T40_04280	COG1301	dicarboxylic acid transport
N4T40_04285	COG1946	Acyl-CoA thioesterase
N4T40_04305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N4T40_04310	COG1040	competence protein
N4T40_04315	COG0494	nUDIX hydrolase
N4T40_04325	COG0598	Magnesium transport protein CorA
N4T40_04335	COG2854	intermembrane phospholipid transfer
N4T40_04345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N4T40_04350	COG1127	ABC transporter
N4T40_04360	COG0513	Belongs to the DEAD box helicase family
N4T40_04380	COG0408	coproporphyrinogen oxidase activity
N4T40_04395	COG1960	acyl-CoA dehydrogenase activity
N4T40_04405	COG1983	PspC domain protein
N4T40_04410	COG0517	IMP dehydrogenase activity
N4T40_04445	COG1106	Psort location Cytoplasmic, score
N4T40_04465	COG0583	DNA-binding transcription factor activity
N4T40_04505	COG1012	belongs to the aldehyde dehydrogenase family
N4T40_04515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N4T40_04520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N4T40_04525	COG0833	amino acid
N4T40_04555	COG1192	Involved in chromosome partitioning
N4T40_04560	COG0628	permease
N4T40_04570	COG1289	transmembrane transporter activity
N4T40_04580	COG4372	Transposase
N4T40_04605	COG2249	NAD(P)H dehydrogenase (quinone) activity
N4T40_04610	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
N4T40_04625	COG0277	FAD linked oxidase domain protein
N4T40_04630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N4T40_04655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N4T40_04660	COG5380	lipid catabolic process
N4T40_04680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N4T40_04730	COG0194	GDP metabolic process
N4T40_04745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N4T40_04765	COG3307	-O-antigen
N4T40_04785	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
N4T40_04790	COG1704	LemA family
N4T40_04800	COG0493	'glutamate synthase
N4T40_04805	COG0070	glutamate synthase
N4T40_04805	COG0069	glutamate synthase activity
N4T40_04805	COG0067	glutamate synthase
N4T40_04855	COG2226	methyltransferase
N4T40_04870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N4T40_04875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N4T40_04920	COG0833	amino acid
N4T40_04985	COG0488	(ABC) transporter
N4T40_04995	COG4221	oxidoreductase activity
N4T40_05000	COG0659	secondary active sulfate transmembrane transporter activity
N4T40_05025	COG0427	acetyl-CoA hydrolase
N4T40_05055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N4T40_05085	COG2329	Antibiotic biosynthesis monooxygenase
N4T40_05100	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N4T40_05165	COG2249	NAD(P)H dehydrogenase (quinone) activity
N4T40_05170	COG1733	regulation of RNA biosynthetic process
N4T40_05205	COG0667	Aldo Keto reductase
N4T40_05225	COG0583	DNA-binding transcription factor activity
N4T40_05230	COG2814	Major facilitator Superfamily
N4T40_05240	COG1113	amino acid transport
N4T40_05245	COG4372	Transposase
N4T40_05275	COG2508	Transcriptional regulator
N4T40_05275	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
N4T40_05310	COG1335	isochorismatase
N4T40_05320	COG1012	belongs to the aldehyde dehydrogenase family
N4T40_05325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N4T40_05335	COG1113	amino acid transport
N4T40_05345	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N4T40_05360	COG2814	Major facilitator Superfamily
N4T40_05370	COG0351	phosphomethylpyrimidine kinase
N4T40_05370	COG0352	thiamine-phosphate diphosphorylase activity
N4T40_05370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N4T40_05390	COG1309	transcriptional regulator
N4T40_05395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N4T40_05420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N4T40_05425	COG3162	membrane
N4T40_05430	COG2198	Histidine kinase
N4T40_05430	COG0784	Response regulator, receiver
N4T40_05430	COG2205	protein histidine kinase activity
N4T40_05455	COG1522	sequence-specific DNA binding
N4T40_05460	COG1335	isochorismatase
N4T40_05465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N4T40_05475	COG0668	transmembrane transport
N4T40_05480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N4T40_05485	COG1519	Transferase
N4T40_05490	COG1902	pentaerythritol trinitrate reductase activity
N4T40_05510	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N4T40_05535	COG0426	domain, Protein
N4T40_05535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N4T40_05540	COG4774	siderophore transport
N4T40_05545	COG2119	membrane
N4T40_05555	COG0508	dehydrogenase complex catalyzes the overall conversion of
N4T40_05565	COG4942	peptidase
N4T40_05580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N4T40_05590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N4T40_05610	COG0189	ligase activity
N4T40_05630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N4T40_05645	COG0708	Exodeoxyribonuclease III
N4T40_05650	COG1393	Belongs to the ArsC family
N4T40_05665	COG3706	GGDEF domain
N4T40_05700	COG2351	hydroxyisourate hydrolase activity
N4T40_05705	COG2233	PERMEase
N4T40_05715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N4T40_05725	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
N4T40_05735	COG3150	esterase
N4T40_05780	COG2918	glutathione biosynthetic process
N4T40_05795	COG2733	membrane
N4T40_05800	COG0436	Aminotransferase
N4T40_05805	COG0534	Mate efflux family protein
N4T40_05890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N4T40_05895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N4T40_05905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N4T40_05910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N4T40_05925	COG0010	Belongs to the arginase family
N4T40_05955	COG2188	Transcriptional regulator
N4T40_05965	COG0523	cobalamin synthesis protein
N4T40_05975	COG1113	amino acid transport
N4T40_05985	COG0625	glutathione transferase activity
N4T40_06005	COG1683	Conserved Protein
N4T40_06010	COG0534	Mate efflux family protein
N4T40_06100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N4T40_06105	COG2116	formate transmembrane transporter activity
N4T40_06125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N4T40_06130	COG1335	isochorismatase
N4T40_06150	COG2983	Belongs to the UPF0260 family
N4T40_06170	COG1194	a g-specific adenine glycosylase
N4T40_06190	COG1064	alcohol dehydrogenase
N4T40_06195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N4T40_06210	COG0583	DNA-binding transcription factor activity
N4T40_06215	COG0656	L-ascorbic acid biosynthetic process
N4T40_06220	COG2814	Major facilitator Superfamily
N4T40_06255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T40_06270	COG2233	PERMEase
N4T40_06275	COG0583	DNA-binding transcription factor activity
N4T40_06310	COG0733	neurotransmitter:sodium symporter activity
N4T40_06350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N4T40_06355	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N4T40_06360	COG0596	Alpha beta hydrolase
N4T40_06385	COG0488	(ABC) transporter
N4T40_06390	COG0586	Pfam SNARE associated Golgi protein
N4T40_06400	COG0187	DNA topoisomerase II activity
N4T40_06410	COG0592	DNA-directed DNA polymerase activity
N4T40_06435	COG0706	membrane insertase activity
N4T40_06450	COG1230	cation diffusion facilitator family transporter
N4T40_06455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N4T40_06470	COG0402	S-adenosylhomocysteine deaminase activity
N4T40_06480	COG0754	glutathionylspermidine amidase activity
N4T40_06490	COG0861	Integral membrane protein TerC family
N4T40_06495	COG0671	phosphoesterase, PA-phosphatase related
N4T40_06505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N4T40_06520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N4T40_06525	COG2951	lytic endotransglycosylase activity
N4T40_06555	COG0583	DNA-binding transcription factor activity
N4T40_06575	COG0657	acetylesterase activity
N4T40_06580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N4T40_06620	COG1047	Peptidyl-prolyl cis-trans
N4T40_06630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N4T40_06635	COG0196	riboflavin kinase activity
N4T40_06645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N4T40_06650	COG1309	transcriptional regulator
N4T40_06655	COG1116	anion transmembrane transporter activity
N4T40_06660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N4T40_06665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N4T40_06670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N4T40_06675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N4T40_06695	COG1028	Short-chain dehydrogenase reductase Sdr
N4T40_06700	COG0546	phosphoglycolate phosphatase activity
N4T40_06760	COG3023	N-Acetylmuramoyl-L-alanine amidase
N4T40_06765	COG0728	peptidoglycan biosynthetic process
N4T40_06790	COG1596	polysaccharide export
N4T40_06795	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N4T40_06800	COG1086	Polysaccharide biosynthesis protein
N4T40_06805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N4T40_06810	COG1083	cytidylyl-transferase
N4T40_06825	COG2089	acid synthase
N4T40_06855	COG1216	Glycosyl transferase, family 2
N4T40_06860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N4T40_06865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N4T40_06880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N4T40_06885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N4T40_06895	COG2186	Transcriptional regulator
N4T40_06905	COG0277	FAD linked oxidase domain protein
N4T40_06910	COG1448	Aminotransferase
N4T40_06920	COG1802	Transcriptional regulator
N4T40_06935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N4T40_06995	COG0564	pseudouridine synthase activity
N4T40_07035	COG0251	oxidation-reduction process
N4T40_07040	COG1113	amino acid transport
N4T40_07045	COG1113	amino acid transport
N4T40_07065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N4T40_07070	COG1960	acyl-CoA dehydrogenase activity
N4T40_07075	COG1024	Enoyl-CoA hydratase
N4T40_07080	COG1024	Enoyl-CoA hydratase
N4T40_07085	COG0477	Major facilitator Superfamily
N4T40_07090	COG3916	Acyl-homoserine-lactone synthase
N4T40_07100	COG2197	response regulator
N4T40_07105	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_07115	COG1960	acyl-CoA dehydrogenase activity
N4T40_07120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N4T40_07120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N4T40_07120	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
N4T40_07120	COG3321	synthase
N4T40_07140	COG2267	carboxylic ester hydrolase activity
N4T40_07160	COG0271	Belongs to the BolA IbaG family
N4T40_07170	COG1192	Involved in chromosome partitioning
N4T40_07185	COG0586	Pfam SNARE associated Golgi protein
N4T40_07190	COG2259	Doxx family
N4T40_07200	COG0519	Catalyzes the synthesis of GMP from XMP
N4T40_07200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N4T40_07245	COG0281	malic enzyme
N4T40_07255	COG2837	iron assimilation
N4T40_07260	COG1280	lysine exporter protein (LysE YggA)
N4T40_07265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N4T40_07270	COG1121	(ABC) transporter
N4T40_07335	COG0386	Belongs to the glutathione peroxidase family
N4T40_07350	COG1309	transcriptional regulator
N4T40_07355	COG0697	spore germination
N4T40_07365	COG0758	DNA mediated transformation
N4T40_07435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N4T40_07445	COG0655	NAD(P)H dehydrogenase (quinone) activity
N4T40_07505	COG1253	flavin adenine dinucleotide binding
N4T40_07515	COG2860	membrane
N4T40_07520	COG0477	Major facilitator Superfamily
N4T40_07530	COG0318	PFAM AMP-dependent synthetase and ligase
N4T40_07545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N4T40_07570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N4T40_07625	COG0589	response to stress
N4T40_07630	COG0659	secondary active sulfate transmembrane transporter activity
N4T40_07650	COG0347	Belongs to the P(II) protein family
N4T40_07655	COG0004	ammonium transporteR
N4T40_07665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N4T40_07665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N4T40_07705	COG0795	lipopolysaccharide-transporting ATPase activity
N4T40_07710	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N4T40_07715	COG0793	Belongs to the peptidase S41A family
N4T40_07730	COG2197	response regulator
N4T40_07740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N4T40_07750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N4T40_07755	COG4974	Belongs to the 'phage' integrase family
N4T40_07780	COG0772	Belongs to the SEDS family
N4T40_07785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N4T40_07790	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N4T40_07795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N4T40_07820	COG0697	spore germination
N4T40_07825	COG1538	Outer membrane efflux protein
N4T40_07845	COG3275	phosphorelay sensor kinase activity
N4T40_07855	COG0181	hydroxymethylbilane synthase activity
N4T40_07900	COG1716	ATPase activity
N4T40_07905	COG0546	phosphoglycolate phosphatase activity
N4T40_08005	COG0596	Alpha beta hydrolase
N4T40_08010	COG2056	Na+-H+ antiporter family
N4T40_08025	COG0326	Molecular chaperone. Has ATPase activity
N4T40_08040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N4T40_08110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N4T40_08115	COG2169	Transcriptional regulator
N4T40_08115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N4T40_08145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N4T40_08155	COG0497	DNA recombination
N4T40_08170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N4T40_08180	COG0237	dephospho-CoA kinase activity
N4T40_08230	COG0195	Participates in both transcription termination and antitermination
N4T40_08245	COG1320	monovalent cation:proton antiporter activity
N4T40_08250	COG2212	antiporter activity
N4T40_08255	COG1863	multisubunit Na H antiporter MnhE subunit
N4T40_08260	COG0651	ATP synthesis coupled electron transport
N4T40_08265	COG1006	Multisubunit Na H antiporter MnhC subunit
N4T40_08270	COG2111	Na H antiporter
N4T40_08270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N4T40_08285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N4T40_08295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N4T40_08305	COG2226	methyltransferase
N4T40_08325	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N4T40_08330	COG1074	ATP-dependent DNA helicase activity
N4T40_08335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N4T40_08340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N4T40_08355	COG0598	Magnesium transport protein CorA
N4T40_08360	COG0789	Transcriptional regulator
N4T40_08365	COG0484	heat shock protein binding
N4T40_08380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N4T40_08380	COG0475	glutathione-regulated potassium exporter activity
N4T40_08385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N4T40_08405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N4T40_08415	COG4535	Mg2 and Co2 transporter CorC
N4T40_08420	COG0425	Belongs to the sulfur carrier protein TusA family
N4T40_08425	COG0644	oxidoreductase
N4T40_08425	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
N4T40_08435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N4T40_08450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N4T40_08455	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N4T40_08465	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
N4T40_08465	COG0493	'glutamate synthase
N4T40_08495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N4T40_08510	COG0534	Mate efflux family protein
N4T40_08520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N4T40_08525	COG1028	Short-chain dehydrogenase reductase Sdr
N4T40_08530	COG0583	DNA-binding transcription factor activity
N4T40_08545	COG0318	PFAM AMP-dependent synthetase and ligase
N4T40_08550	COG1530	ribonuclease E activity
N4T40_08560	COG0546	phosphoglycolate phosphatase activity
N4T40_08565	COG2378	regulation of single-species biofilm formation
N4T40_08570	COG0625	glutathione transferase activity
N4T40_08580	COG0583	DNA-binding transcription factor activity
N4T40_08645	COG0473	3-isopropylmalate dehydrogenase activity
N4T40_08700	COG1301	dicarboxylic acid transport
N4T40_08710	COG1560	Kdo2-lipid A biosynthetic process
N4T40_08715	COG1280	lysine exporter protein (LysE YggA)
N4T40_08720	COG0488	(ABC) transporter
N4T40_08725	COG2900	Belongs to the SlyX family
N4T40_08735	COG1733	regulation of RNA biosynthetic process
N4T40_08760	COG0210	DNA helicase
N4T40_08765	COG0724	RNA recognition motif
N4T40_08785	COG4651	solute:proton antiporter activity
N4T40_08785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N4T40_08810	COG0788	formyltetrahydrofolate deformylase activity
N4T40_08910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N4T40_08910	COG2813	Specifically methylates the guanine in position
N4T40_08920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N4T40_08930	COG4774	siderophore transport
N4T40_08940	COG0740	serine-type endopeptidase activity
N4T40_08960	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
N4T40_08960	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
N4T40_08965	COG0280	phosphate acetyltransferase
N4T40_08965	COG0857	belongs to the CobB CobQ family
N4T40_08970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N4T40_08980	COG0800	Aldolase
N4T40_08990	COG3265	gluconokinase activity
N4T40_08995	COG1012	belongs to the aldehyde dehydrogenase family
N4T40_09005	COG2267	carboxylic ester hydrolase activity
N4T40_09020	COG0793	Belongs to the peptidase S41A family
N4T40_09055	COG1426	Protein conserved in bacteria
N4T40_09095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N4T40_09105	COG1162	GTPase activity
N4T40_09110	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N4T40_09125	COG1538	Outer membrane efflux protein
N4T40_09130	COG1136	(ABC) transporter
N4T40_09130	COG0577	efflux transmembrane transporter activity
N4T40_09135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T40_09160	COG0028	Belongs to the TPP enzyme family
N4T40_09165	COG0440	acetolactate synthase activity
N4T40_09190	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_09200	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_09210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N4T40_09225	COG0084	hydrolase, TatD family'
N4T40_09240	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N4T40_09250	COG0583	DNA-binding transcription factor activity
N4T40_09260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N4T40_09265	COG2814	Major facilitator Superfamily
N4T40_09275	COG0697	spore germination
N4T40_09305	COG3622	Belongs to the hyi family
N4T40_09310	COG2084	Dehydrogenase
N4T40_09315	COG1024	Enoyl-CoA hydratase
N4T40_09320	COG0784	Response regulator, receiver
N4T40_09320	COG2205	protein histidine kinase activity
N4T40_09320	COG5002	protein histidine kinase activity
N4T40_09340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N4T40_09350	COG3956	TIGRFAM MazG family protein
N4T40_09355	COG1555	photosystem II stabilization
N4T40_09360	COG0617	tRNA 3'-terminal CCA addition
N4T40_09365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N4T40_09385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4T40_09390	COG3028	Belongs to the UPF0307 family
N4T40_09395	COG0318	PFAM AMP-dependent synthetase and ligase
N4T40_09410	COG0625	glutathione transferase activity
N4T40_09415	COG1238	metal cluster binding
N4T40_09455	COG0072	phenylalanine-tRNA ligase activity
N4T40_09485	COG0248	Ppx GppA phosphatase
N4T40_09495	COG0037	tRNA processing
N4T40_09535	COG1764	response to oxidative stress
N4T40_09540	COG1846	Transcriptional regulator
N4T40_09550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N4T40_09610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N4T40_09615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N4T40_09620	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N4T40_09680	COG1214	PFAM Peptidase M22, glycoprotease
N4T40_09695	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N4T40_09705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N4T40_09710	COG0561	phosphatase activity
N4T40_09720	COG2132	Multicopper oxidase
N4T40_09740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N4T40_09745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N4T40_09750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N4T40_09780	COG1063	alcohol dehydrogenase
N4T40_09785	COG0583	DNA-binding transcription factor activity
N4T40_09790	COG1960	acyl-CoA dehydrogenase activity
N4T40_09795	COG2814	Major facilitator Superfamily
N4T40_09800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N4T40_09810	COG1053	succinate dehydrogenase
N4T40_09815	COG0583	DNA-binding transcription factor activity
N4T40_09830	COG0583	DNA-binding transcription factor activity
N4T40_09860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N4T40_09920	COG0384	phenazine biosynthesis protein PhzF
N4T40_09930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N4T40_09950	COG0745	RESPONSE REGULATOR receiver
N4T40_09990	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
N4T40_10020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N4T40_10025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N4T40_10045	COG0583	DNA-binding transcription factor activity
N4T40_10065	COG0668	transmembrane transport
N4T40_10075	COG2081	HI0933 family
N4T40_10080	COG2515	1-aminocyclopropane-1-carboxylate deaminase
N4T40_10110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N4T40_10110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N4T40_10120	COG0489	protein tyrosine kinase activity
N4T40_10170	COG0305	Participates in initiation and elongation during chromosome replication
N4T40_10210	COG0582	viral genome integration into host DNA
N4T40_10225	COG2828	Protein conserved in bacteria
N4T40_10230	COG0142	geranyltranstransferase activity
N4T40_10235	COG2315	Protein conserved in bacteria
N4T40_10250	COG1752	Esterase of the alpha-beta hydrolase superfamily
N4T40_10270	COG2194	sulfuric ester hydrolase activity
N4T40_10275	COG0745	RESPONSE REGULATOR receiver
N4T40_10280	COG0642	Histidine kinase
N4T40_10290	COG0004	ammonium transporteR
N4T40_10315	COG0525	valine-tRNA ligase activity
N4T40_10325	COG1028	Short-chain dehydrogenase reductase Sdr
N4T40_10335	COG0393	Putative heavy-metal-binding
N4T40_10340	COG0393	Putative heavy-metal-binding
N4T40_10345	COG1538	Outer membrane efflux protein
N4T40_10355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T40_10360	COG0671	phosphoesterase, PA-phosphatase related
N4T40_10365	COG0215	cysteine-tRNA ligase activity
N4T40_10390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N4T40_10405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N4T40_10405	COG1648	precorrin-2 dehydrogenase activity
N4T40_10410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N4T40_10415	COG1733	regulation of RNA biosynthetic process
N4T40_10425	COG0531	amino acid
N4T40_10440	COG0321	lipoyl(octanoyl) transferase activity
N4T40_10445	COG2921	Belongs to the UPF0250 family
N4T40_10480	COG2009	succinate dehydrogenase
N4T40_10485	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N4T40_10490	COG1053	succinate dehydrogenase
N4T40_10495	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N4T40_10520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N4T40_10540	COG2354	Protein conserved in bacteria
N4T40_10545	COG2321	neutral zinc metallopeptidase
N4T40_10565	COG2843	Capsule synthesis protein
N4T40_10580	COG0589	response to stress
N4T40_10600	COG0505	Belongs to the CarA family
N4T40_10625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N4T40_10630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N4T40_10680	COG0477	Major facilitator Superfamily
N4T40_10685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N4T40_10700	COG1597	lipid kinase activity
N4T40_10705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N4T40_10735	COG0584	glycerophosphoryl diester phosphodiesterase
N4T40_10755	COG0741	lytic transglycosylase activity
N4T40_10775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N4T40_10800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N4T40_10810	COG3811	Belongs to the UPF0386 family
N4T40_10855	COG0778	Nitroreductase
N4T40_10870	COG1929	Belongs to the glycerate kinase type-1 family
N4T40_10875	COG0243	molybdopterin cofactor binding
N4T40_10880	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N4T40_10885	COG3339	Conserved Protein
N4T40_10895	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N4T40_10910	COG1113	amino acid transport
N4T40_10920	COG0019	diaminopimelate decarboxylase activity
N4T40_10930	COG1280	lysine exporter protein (LysE YggA)
N4T40_10935	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N4T40_10965	COG0463	Glycosyl transferase, family 2
N4T40_10985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T40_11020	COG4591	ABC-type transport system involved in lipoprotein release permease component
N4T40_11025	COG1136	(ABC) transporter
N4T40_11030	COG2333	competence protein COMEC
N4T40_11030	COG0658	competence protein
N4T40_11040	COG0616	signal peptide processing
N4T40_11040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N4T40_11045	COG0596	Alpha beta hydrolase
N4T40_11050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N4T40_11060	COG0628	permease
N4T40_11095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N4T40_11115	COG0823	Involved in the tonB-independent uptake of proteins
N4T40_11135	COG0824	Thioesterase
N4T40_11140	COG1473	amidohydrolase
N4T40_11160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N4T40_11160	COG0047	phosphoribosylformylglycinamidine synthase activity
N4T40_11165	COG2814	Major facilitator Superfamily
N4T40_11180	COG1024	Enoyl-CoA hydratase
N4T40_11185	COG1051	belongs to the nudix hydrolase family
N4T40_11185	COG1056	cytidyltransferase-related domain
N4T40_11195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N4T40_11210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N4T40_11225	COG4625	pathogenesis
N4T40_11230	COG0583	DNA-binding transcription factor activity
N4T40_11235	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N4T40_11240	COG4208	sulfate ABC transporter
N4T40_11245	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N4T40_11255	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N4T40_11260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N4T40_11285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N4T40_11300	COG0681	Belongs to the peptidase S26 family
N4T40_11315	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N4T40_11325	COG1381	Involved in DNA repair and RecF pathway recombination
N4T40_11330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N4T40_11340	COG4221	oxidoreductase activity
N4T40_11380	COG0436	Aminotransferase
N4T40_11395	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_11405	COG0556	nucleotide-excision repair
N4T40_11460	COG2070	2-Nitropropane dioxygenase
N4T40_11490	COG1215	transferase activity, transferring glycosyl groups
N4T40_11505	COG0415	Belongs to the DNA photolyase family
N4T40_11515	COG1252	NADH dehydrogenase
N4T40_11520	COG1686	Belongs to the peptidase S11 family
N4T40_11535	COG1187	pseudouridine synthase activity
N4T40_11560	COG0477	Major facilitator Superfamily
N4T40_11565	COG0583	DNA-binding transcription factor activity
N4T40_11570	COG1823	symporter activity
N4T40_11580	COG0612	Peptidase, M16
N4T40_11605	COG0352	thiamine-phosphate diphosphorylase activity
N4T40_11640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4T40_11655	COG1309	transcriptional regulator
N4T40_11665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N4T40_11670	COG0076	glutamate decarboxylase activity
N4T40_11680	COG1522	sequence-specific DNA binding
N4T40_11685	COG3961	Belongs to the TPP enzyme family
N4T40_11690	COG1113	amino acid transport
N4T40_11695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N4T40_11700	COG0573	inorganic phosphate transmembrane transporter activity
N4T40_11710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N4T40_11715	COG0616	signal peptide processing
N4T40_11750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N4T40_11755	COG1686	Belongs to the peptidase S11 family
N4T40_11780	COG0583	DNA-binding transcription factor activity
N4T40_11785	COG1067	ATP-dependent peptidase activity
N4T40_11790	COG2211	Major facilitator Superfamily
N4T40_11810	COG4943	cyclic-guanylate-specific phosphodiesterase activity
N4T40_11830	COG1966	Carbon starvation protein
N4T40_11835	COG2879	small protein
N4T40_11855	COG1741	Belongs to the pirin family
N4T40_11865	COG2964	Protein conserved in bacteria
N4T40_11880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N4T40_11885	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N4T40_11890	COG4605	iron ion homeostasis
N4T40_11895	COG4604	ABC transporter, ATP-binding protein
N4T40_11900	COG4607	ABC-type enterochelin transport system periplasmic component
N4T40_11905	COG4774	siderophore transport
N4T40_11915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N4T40_11920	COG1021	2,3-dihydroxybenzoate-AMP ligase
N4T40_11925	COG1535	isochorismatase
N4T40_11925	COG3433	isochorismatase activity
N4T40_11935	COG1132	(ABC) transporter
N4T40_11940	COG1132	(ABC) transporter
N4T40_11945	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
N4T40_11955	COG1169	isochorismate synthase
N4T40_11970	COG3739	integral membrane protein
N4T40_11995	COG0302	gtp cyclohydrolase
N4T40_12005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N4T40_12040	COG0512	Glutamine amidotransferase of anthranilate synthase
N4T40_12215	COG5410	chromosome segregation
N4T40_12335	COG1598	PFAM Uncharacterised protein family UPF0150
N4T40_12410	COG0582	viral genome integration into host DNA
N4T40_12425	COG0174	glutamine synthetase
N4T40_12435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N4T40_12470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N4T40_12475	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N4T40_12480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N4T40_12510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N4T40_12515	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N4T40_12520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N4T40_12535	COG1960	acyl-CoA dehydrogenase activity
N4T40_12540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N4T40_12545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N4T40_12555	COG2223	nitrite transmembrane transporter activity
N4T40_12565	COG0024	Methionine aminopeptidase
N4T40_12570	COG0052	Belongs to the universal ribosomal protein uS2 family
N4T40_12585	COG2207	Transcriptional regulator
N4T40_12610	COG2951	lytic endotransglycosylase activity
N4T40_12615	COG0772	Belongs to the SEDS family
N4T40_12630	COG0842	Transport permease protein
N4T40_12635	COG1131	(ABC) transporter
N4T40_12640	COG0582	viral genome integration into host DNA
N4T40_12950	COG0739	heme binding
N4T40_13070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T40_13095	COG4215	(ABC) transporter
N4T40_13100	COG4160	amino acid transport
N4T40_13105	COG4598	ABC transporter
N4T40_13115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N4T40_13125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N4T40_13140	COG1720	tRNA m6t6A37 methyltransferase activity
N4T40_13150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N4T40_13165	COG0642	Histidine kinase
N4T40_13175	COG0494	nUDIX hydrolase
N4T40_13185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N4T40_13190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N4T40_13195	COG3139	Protein of unknown function (DUF1315)
N4T40_13200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N4T40_13205	COG1301	dicarboxylic acid transport
N4T40_13210	COG1960	acyl-CoA dehydrogenase activity
N4T40_13215	COG2819	hydrolase of the alpha beta superfamily
N4T40_13225	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N4T40_13235	COG2195	Cleaves the N-terminal amino acid of tripeptides
N4T40_13240	COG1234	tRNA 3'-trailer cleavage
N4T40_13270	COG2363	Small membrane protein
N4T40_13295	COG0513	Belongs to the DEAD box helicase family
N4T40_13305	COG0778	Nitroreductase
N4T40_13335	COG1286	toxin biosynthetic process
N4T40_13365	COG1610	YqeY-like protein
N4T40_13430	COG2831	hemolysin activation secretion protein
N4T40_13435	COG3210	domain, Protein
N4T40_13435	COG3210	domain, Protein
N4T40_13515	COG3111	PFAM Bacterial OB fold (BOF) protein
N4T40_13540	COG3243	poly(R)-hydroxyalkanoic acid synthase
N4T40_13545	COG0786	glutamate:sodium symporter activity
N4T40_13555	COG2186	Transcriptional regulator
N4T40_13605	COG0477	Major facilitator Superfamily
N4T40_13625	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_13640	COG2985	domain, Protein
N4T40_13650	COG2995	paraquat-inducible protein a
N4T40_13655	COG3008	intermembrane lipid transfer
N4T40_13655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N4T40_13665	COG1794	racemase activity, acting on amino acids and derivatives
N4T40_13700	COG1301	dicarboxylic acid transport
N4T40_13710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N4T40_13715	COG2011	ABC-type metal ion transport system permease component
N4T40_13720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N4T40_13725	COG1464	Belongs to the NlpA lipoprotein family
N4T40_13730	COG0151	Belongs to the GarS family
N4T40_13735	COG0138	bifunctional purine biosynthesis protein purh
N4T40_13740	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
N4T40_13770	COG2308	Evidence 4 Homologs of previously reported genes of
N4T40_13780	COG1305	Transglutaminase-like
N4T40_13790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N4T40_13795	COG0305	Participates in initiation and elongation during chromosome replication
N4T40_13820	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N4T40_13830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N4T40_13835	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N4T40_13865	COG1215	transferase activity, transferring glycosyl groups
N4T40_13870	COG3658	cytochrome
N4T40_13880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N4T40_13895	COG0583	DNA-binding transcription factor activity
N4T40_13925	COG1960	acyl-CoA dehydrogenase activity
N4T40_13930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N4T40_13935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N4T40_13960	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N4T40_13965	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N4T40_13975	COG2205	protein histidine kinase activity
N4T40_13980	COG0745	RESPONSE REGULATOR receiver
N4T40_13985	COG0174	glutamine synthetase
N4T40_14005	COG0729	surface antigen
N4T40_14045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N4T40_14140	COG1484	DNA-dependent DNA replication
N4T40_14360	COG2026	Addiction module toxin, RelE StbE family
N4T40_14400	COG0592	DNA-directed DNA polymerase activity
N4T40_14430	COG4372	Transposase
N4T40_14440	COG2963	transposase activity
N4T40_14450	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_14505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N4T40_14530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N4T40_14535	COG2814	Major facilitator Superfamily
N4T40_14550	COG0583	DNA-binding transcription factor activity
N4T40_14565	COG1187	pseudouridine synthase activity
N4T40_14585	COG0802	atpase or kinase
N4T40_14590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N4T40_14600	COG1923	regulation of RNA biosynthetic process
N4T40_14605	COG0697	spore germination
N4T40_14630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N4T40_14635	COG0519	Catalyzes the synthesis of GMP from XMP
N4T40_14635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N4T40_14640	COG4302	ethanolamine ammonia-lyase activity
N4T40_14645	COG4303	Ethanolamine ammonia lyase large subunit
N4T40_14650	COG0531	amino acid
N4T40_14670	COG1454	alcohol dehydrogenase
N4T40_14675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N4T40_14700	COG0308	aminopeptidase N
N4T40_14720	COG1605	Chorismate mutase
N4T40_14740	COG1309	transcriptional regulator
N4T40_14750	COG0668	transmembrane transport
N4T40_14780	COG4773	Receptor
N4T40_14800	COG0488	(ABC) transporter
N4T40_14805	COG0589	response to stress
N4T40_14845	COG3135	benzoate transporter
N4T40_14850	COG1522	sequence-specific DNA binding
N4T40_14860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N4T40_14865	COG0583	DNA-binding transcription factor activity
N4T40_14875	COG0183	Belongs to the thiolase family
N4T40_14885	COG2030	dehydratase
N4T40_14890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N4T40_14915	COG0824	Thioesterase
N4T40_14920	COG1454	alcohol dehydrogenase
N4T40_14930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N4T40_14950	COG0069	glutamate synthase activity
N4T40_14970	COG2814	Major facilitator Superfamily
N4T40_14985	COG0511	ligase activity, forming carbon-carbon bonds
N4T40_15000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N4T40_15000	COG1116	anion transmembrane transporter activity
N4T40_15005	COG0745	RESPONSE REGULATOR receiver
N4T40_15015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N4T40_15015	COG2146	nitrite reductase [NAD(P)H] activity
N4T40_15020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N4T40_15025	COG0243	molybdopterin cofactor binding
N4T40_15035	COG0243	molybdopterin cofactor binding
N4T40_15040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N4T40_15055	COG0521	Mo-molybdopterin cofactor biosynthetic process
N4T40_15055	COG0315	cyclic pyranopterin monophosphate synthase activity
N4T40_15060	COG0303	'Molybdopterin
N4T40_15070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N4T40_15075	COG0697	spore germination
N4T40_15095	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N4T40_15100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N4T40_15155	COG2204	response regulator
N4T40_15160	COG3852	Histidine kinase
N4T40_15185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N4T40_15190	COG0575	Belongs to the CDS family
N4T40_15225	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N4T40_15240	COG2137	regulation of response to DNA damage stimulus
N4T40_15250	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N4T40_15255	COG1011	Hydrolase
N4T40_15280	COG1522	sequence-specific DNA binding
N4T40_15290	COG1113	amino acid transport
N4T40_15310	COG0659	secondary active sulfate transmembrane transporter activity
N4T40_15315	COG2135	peptidase activity
N4T40_15330	COG3300	MHYT domain
N4T40_15330	COG5001	Diguanylate cyclase
N4T40_15350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N4T40_15350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N4T40_15350	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N4T40_15355	COG1105	Belongs to the carbohydrate kinase PfkB family
N4T40_15360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N4T40_15360	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4T40_15390	COG0024	Methionine aminopeptidase
N4T40_15395	COG0583	DNA-binding transcription factor activity
N4T40_15405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N4T40_15410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N4T40_15415	COG0516	GMP reductase activity
N4T40_15415	COG0517	IMP dehydrogenase activity
N4T40_15440	COG0552	protein localization to endoplasmic reticulum
N4T40_15450	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N4T40_15465	COG4890	Cyd operon protein YbgT
N4T40_15470	COG1294	oxidase, subunit
N4T40_15490	COG1585	Membrane protein implicated in regulation of membrane protease activity
N4T40_15500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N4T40_15525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N4T40_15530	COG0569	domain protein
N4T40_15535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N4T40_15575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N4T40_15580	COG0542	response to heat
N4T40_15605	COG1902	pentaerythritol trinitrate reductase activity
N4T40_15605	COG0446	pyridine nucleotide-disulphide oxidoreductase
N4T40_15650	COG2323	membrane
N4T40_15655	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N4T40_15665	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N4T40_15670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N4T40_15675	COG0183	Belongs to the thiolase family
N4T40_15680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N4T40_15685	COG0596	Alpha beta hydrolase
N4T40_15690	COG2271	Major facilitator Superfamily
N4T40_15695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N4T40_15700	COG3485	protocatechuate 3,4-dioxygenase
N4T40_15705	COG3485	protocatechuate 3,4-dioxygenase
N4T40_15710	COG0710	3-dehydroquinate dehydratase activity
N4T40_15715	COG3420	alginic acid biosynthetic process
N4T40_15720	COG3659	wide pore channel activity
N4T40_15725	COG4993	Dehydrogenase
N4T40_15735	COG3293	Transposase
N4T40_15740	COG2391	methyltransferase activity
N4T40_15755	COG1414	Transcriptional regulator
N4T40_15760	COG0583	DNA-binding transcription factor activity
N4T40_15765	COG1960	acyl-CoA dehydrogenase activity
N4T40_15845	COG2188	Transcriptional regulator
N4T40_15860	COG0583	DNA-binding transcription factor activity
N4T40_15895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N4T40_15930	COG1960	acyl-CoA dehydrogenase activity
N4T40_15935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N4T40_15940	COG1846	Transcriptional regulator
N4T40_15945	COG1012	belongs to the aldehyde dehydrogenase family
N4T40_15950	COG0129	dihydroxy-acid dehydratase activity
N4T40_15960	COG0583	DNA-binding transcription factor activity
N4T40_15965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N4T40_15975	COG2084	Dehydrogenase
N4T40_15980	COG2207	Transcriptional regulator
N4T40_15985	COG1064	alcohol dehydrogenase
N4T40_15995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N4T40_16000	COG1120	ATPase activity
N4T40_16020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N4T40_16065	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_16110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N4T40_16135	COG2814	Major facilitator Superfamily
N4T40_16155	COG2205	protein histidine kinase activity
N4T40_16190	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
N4T40_16200	COG0753	catalase activity
N4T40_16280	COG1535	isochorismatase
N4T40_16280	COG3433	isochorismatase activity
N4T40_16285	COG1028	Short-chain dehydrogenase reductase Sdr
N4T40_16290	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N4T40_16295	COG4149	molybdate abc transporter
N4T40_16300	COG0725	ABC transporter, periplasmic molybdate-binding protein
N4T40_16310	COG4638	Rieske (2fe-2S)
N4T40_16315	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
N4T40_16320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4T40_16320	COG0543	2 iron, 2 sulfur cluster binding
N4T40_16335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N4T40_16345	COG1028	Short-chain dehydrogenase reductase Sdr
N4T40_16360	COG2207	Transcriptional regulator
N4T40_16365	COG1028	Short-chain dehydrogenase reductase Sdr
N4T40_16370	COG2610	gluconate transmembrane transporter activity
N4T40_16385	COG1309	transcriptional regulator
N4T40_16400	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_16410	COG0583	DNA-binding transcription factor activity
N4T40_16425	COG2031	fatty acid transporter
N4T40_16430	COG0183	Belongs to the thiolase family
N4T40_16435	COG0583	DNA-binding transcription factor activity
N4T40_16440	COG0583	DNA-binding transcription factor activity
N4T40_16455	COG1027	Aspartate ammonia-lyase
N4T40_16465	COG0477	Major facilitator Superfamily
N4T40_16500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N4T40_16525	COG0789	Transcriptional regulator
N4T40_16535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T40_16540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N4T40_16545	COG1538	Outer membrane efflux protein
N4T40_16550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N4T40_16565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N4T40_16600	COG0798	PFAM Bile acid sodium symporter
N4T40_16635	COG4691	Plasmid stability protein
N4T40_16660	COG0431	NADPH-dependent FMN reductase
N4T40_16665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4T40_16720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N4T40_16725	COG4521	taurine ABC transporter
N4T40_16740	COG2188	Transcriptional regulator
N4T40_16750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N4T40_16755	COG1733	regulation of RNA biosynthetic process
N4T40_16760	COG2207	Transcriptional regulator
N4T40_16760	COG3708	Transcriptional regulator
N4T40_16775	COG0730	response to heat
N4T40_16790	COG3453	Protein conserved in bacteria
N4T40_16790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N4T40_16800	COG3781	membrane
N4T40_16805	COG1063	alcohol dehydrogenase
N4T40_16820	COG0508	dehydrogenase complex catalyzes the overall conversion of
N4T40_16825	COG0022	dehydrogenase e1 component
N4T40_16830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N4T40_16835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N4T40_16850	COG3706	GGDEF domain
N4T40_16865	COG0133	tryptophan synthase activity
N4T40_16875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N4T40_16910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N4T40_16935	COG2226	methyltransferase
N4T40_16995	COG0842	Transport permease protein
N4T40_17000	COG0842	Transport permease protein
N4T40_17020	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N4T40_17025	COG4773	Receptor
N4T40_17045	COG0730	response to heat
N4T40_17050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N4T40_17065	COG0406	alpha-ribazole phosphatase activity
N4T40_17090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N4T40_17120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N4T40_17130	COG4264	IucA IucC family
N4T40_17135	COG4264	IucA IucC family
N4T40_17140	COG2814	Major facilitator Superfamily
N4T40_17155	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N4T40_17170	COG1960	acyl-CoA dehydrogenase activity
N4T40_17175	COG1960	acyl-CoA dehydrogenase activity
N4T40_17180	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N4T40_17185	COG2207	Transcriptional regulator
N4T40_17190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N4T40_17195	COG0776	regulation of translation
N4T40_17220	COG0822	iron-sulfur transferase activity
N4T40_17225	COG0316	Belongs to the HesB IscA family
N4T40_17255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N4T40_17275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N4T40_17280	COG0702	epimerase
N4T40_17315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N4T40_17325	COG0339	signal peptide processing
N4T40_17375	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N4T40_17380	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N4T40_17410	COG0776	regulation of translation
N4T40_17475	COG0084	hydrolase, TatD family'
N4T40_17495	COG1663	tetraacyldisaccharide 4'-kinase activity
N4T40_17500	COG1132	(ABC) transporter
N4T40_17510	COG0811	peptide transport
N4T40_17515	COG1475	DNA binding
N4T40_17520	COG1192	Involved in chromosome partitioning
N4T40_17530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N4T40_17545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N4T40_17550	COG0191	fructose-bisphosphate aldolase activity
N4T40_17570	COG0424	maF-like protein
N4T40_17575	COG2850	peptidyl-arginine hydroxylation
N4T40_17585	COG0640	Transcriptional regulator
N4T40_17595	COG3619	membrane
N4T40_17600	COG3122	Protein conserved in bacteria
N4T40_17605	COG1132	(ABC) transporter
N4T40_17625	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N4T40_17630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N4T40_17640	COG0506	proline dehydrogenase activity
N4T40_17640	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N4T40_17640	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N4T40_17645	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N4T40_17660	COG3698	Phosphodiester glycosidase
N4T40_17670	COG2353	YceI-like domain
N4T40_17680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N4T40_17725	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N4T40_17725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N4T40_17750	COG3539	Fimbrial protein
N4T40_17755	COG3121	Chaperone
N4T40_17780	COG0697	spore germination
N4T40_17790	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N4T40_17820	COG1309	transcriptional regulator
N4T40_17835	COG1522	sequence-specific DNA binding
N4T40_17845	COG1126	abc transporter atp-binding protein
N4T40_17850	COG0765	amino acid transport
N4T40_17855	COG0765	amino acid transport
N4T40_17885	COG1464	Belongs to the NlpA lipoprotein family
N4T40_17895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N4T40_17900	COG2011	ABC-type metal ion transport system permease component
N4T40_17905	COG0012	GTP binding
N4T40_17930	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N4T40_17955	COG0436	Aminotransferase
N4T40_17970	COG0386	Belongs to the glutathione peroxidase family
N4T40_17980	COG0436	Aminotransferase
N4T40_17985	COG1301	dicarboxylic acid transport
N4T40_18020	COG3634	alkyl hydroperoxide reductase activity
N4T40_18035	COG0583	DNA-binding transcription factor activity
N4T40_18040	COG0798	PFAM Bile acid sodium symporter
N4T40_18045	COG0640	Transcriptional regulator
N4T40_18070	COG0583	DNA-binding transcription factor activity
N4T40_18080	COG1953	Uracil, thiamine, allantoin
N4T40_18090	COG2175	clavaminate synthase activity
N4T40_18095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N4T40_18105	COG4521	taurine ABC transporter
N4T40_18120	COG0477	Major facilitator Superfamily
N4T40_18140	COG1271	oxidase subunit
N4T40_18145	COG1294	oxidase, subunit
N4T40_18175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N4T40_18195	COG3052	prosthetic group binding
N4T40_18200	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
N4T40_18210	COG0583	DNA-binding transcription factor activity
N4T40_18220	COG2814	Major facilitator Superfamily
N4T40_18240	COG1346	cytolysis
N4T40_18250	COG0583	DNA-binding transcription factor activity
N4T40_18255	COG0625	glutathione transferase activity
N4T40_18260	COG0625	glutathione transferase activity
N4T40_18265	COG0583	DNA-binding transcription factor activity
N4T40_18280	COG1045	serine acetyltransferase
N4T40_18285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N4T40_18290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N4T40_18300	COG1280	lysine exporter protein (LysE YggA)
N4T40_18320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4T40_18325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4T40_18330	COG1126	abc transporter atp-binding protein
N4T40_18335	COG0765	amino acid transport
N4T40_18340	COG0765	amino acid transport
N4T40_18360	COG2205	protein histidine kinase activity
N4T40_18360	COG0784	Response regulator, receiver
N4T40_18380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N4T40_18400	COG1028	Short-chain dehydrogenase reductase Sdr
N4T40_18450	COG0583	DNA-binding transcription factor activity
N4T40_18470	COG0318	PFAM AMP-dependent synthetase and ligase
N4T40_18475	COG1309	transcriptional regulator
N4T40_18480	COG1960	acyl-CoA dehydrogenase activity
N4T40_18485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N4T40_18490	COG1024	Enoyl-CoA hydratase
N4T40_18495	COG4770	biotin carboxylase activity
N4T40_18505	COG0583	DNA-binding transcription factor activity
N4T40_18520	COG1960	acyl-CoA dehydrogenase activity
N4T40_18530	COG2814	Major facilitator Superfamily
N4T40_18540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N4T40_18545	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N4T40_18550	COG2814	Major facilitator Superfamily
N4T40_18555	COG1960	acyl-CoA dehydrogenase activity
N4T40_18560	COG1024	Enoyl-CoA hydratase
N4T40_18565	COG1028	Short-chain dehydrogenase reductase Sdr
N4T40_18570	COG1250	3-hydroxyacyl-CoA dehydrogenase
N4T40_18575	COG0183	Belongs to the thiolase family
N4T40_18595	COG1280	lysine exporter protein (LysE YggA)
N4T40_18600	COG2192	nodulation
N4T40_18615	COG1024	Enoyl-CoA hydratase
N4T40_18630	COG1960	acyl-CoA dehydrogenase activity
N4T40_18635	COG2814	Major facilitator Superfamily
N4T40_18640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N4T40_18645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N4T40_18660	COG3842	ATPase activity
N4T40_18665	COG1840	ABC-type Fe3 transport system, periplasmic component
N4T40_18675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N4T40_18680	COG1414	Transcriptional regulator
N4T40_18690	COG0583	DNA-binding transcription factor activity
N4T40_18695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N4T40_18700	COG1012	belongs to the aldehyde dehydrogenase family
N4T40_18715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N4T40_18725	COG1012	belongs to the aldehyde dehydrogenase family
N4T40_18730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N4T40_18735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N4T40_18740	COG2267	carboxylic ester hydrolase activity
N4T40_18760	COG3038	cytochrome b561
N4T40_18765	COG0753	catalase activity
N4T40_18800	COG2050	protein possibly involved in aromatic compounds catabolism
N4T40_18810	COG3327	negative regulation of DNA-templated transcription, initiation
N4T40_18815	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
N4T40_18820	COG0183	Belongs to the thiolase family
N4T40_18825	COG1250	3-hydroxyacyl-CoA dehydrogenase
N4T40_18830	COG1024	Enoyl-CoA hydratase
N4T40_18835	COG1024	Enoyl-CoA hydratase
N4T40_18840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4T40_18845	COG2151	metal-sulfur cluster biosynthetic enzyme
N4T40_18850	COG3396	Phenylacetate-CoA oxygenase
N4T40_18855	COG3460	Phenylacetate-CoA oxygenase
N4T40_18860	COG3396	Phenylacetate-CoA oxygenase
N4T40_18865	COG2030	dehydratase
N4T40_18865	COG1012	belongs to the aldehyde dehydrogenase family
N4T40_18870	COG1760	l-serine dehydratase
N4T40_18875	COG0531	amino acid
N4T40_18880	COG1012	belongs to the aldehyde dehydrogenase family
N4T40_18905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N4T40_18925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N4T40_18935	COG0789	Transcriptional regulator
N4T40_18945	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N4T40_18960	COG2807	transmembrane transport
N4T40_18965	COG0590	tRNA wobble adenosine to inosine editing
N4T40_19085	COG1116	anion transmembrane transporter activity
N4T40_19090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4T40_19100	COG0864	Transcriptional regulator
N4T40_19110	COG1733	regulation of RNA biosynthetic process
N4T40_19115	COG2249	NAD(P)H dehydrogenase (quinone) activity
N4T40_19120	COG0439	Biotin carboxylase
N4T40_19135	COG1063	alcohol dehydrogenase
N4T40_19160	COG0038	chloride channel
N4T40_19165	COG4770	biotin carboxylase activity
N4T40_19185	COG1914	H( )-stimulated, divalent metal cation uptake system
N4T40_19190	COG0583	DNA-binding transcription factor activity
N4T40_19225	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_19270	COG1250	3-hydroxyacyl-CoA dehydrogenase
N4T40_19295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N4T40_19320	COG2814	Major facilitator Superfamily
N4T40_19335	COG1560	Kdo2-lipid A biosynthetic process
N4T40_19345	COG5006	permease, DMT superfamily
N4T40_19350	COG1522	sequence-specific DNA binding
N4T40_19365	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N4T40_19375	COG4122	O-methyltransferase activity
N4T40_19405	COG1538	Outer membrane efflux protein
N4T40_19410	COG1137	ATPase activity
N4T40_19415	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N4T40_19425	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N4T40_19650	COG5377	YqaJ viral recombinase family
N4T40_19660	COG0210	DNA helicase
N4T40_19720	COG2814	Major facilitator Superfamily
N4T40_19760	COG1278	Cold shock
N4T40_19765	COG1280	lysine exporter protein (LysE YggA)
N4T40_19795	COG1570	exodeoxyribonuclease VII activity
N4T40_19880	COG2871	sodium ion transport
N4T40_19890	COG0583	DNA-binding transcription factor activity
N4T40_19900	COG4638	Rieske (2fe-2S)
N4T40_19910	COG0633	Ferredoxin
N4T40_19910	COG0543	2 iron, 2 sulfur cluster binding
N4T40_19915	COG1028	Short-chain dehydrogenase reductase Sdr
N4T40_19920	COG3135	benzoate transporter
N4T40_19925	COG2814	Major facilitator Superfamily
N4T40_19940	COG1643	Atp-dependent helicase
N4T40_19945	COG0450	alkyl hydroperoxide reductase
N4T40_19955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N4T40_19965	COG3634	alkyl hydroperoxide reductase activity
N4T40_19985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N4T40_19990	COG0625	glutathione transferase activity
N4T40_20000	COG2885	chlorophyll binding
N4T40_20035	COG0542	response to heat
N4T40_20050	COG1765	OsmC-like protein
N4T40_20065	COG0667	Aldo Keto reductase
N4T40_20080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N4T40_20090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N4T40_20100	COG0582	viral genome integration into host DNA
N4T40_20170	COG0739	heme binding
N4T40_20195	COG1598	PFAM Uncharacterised protein family UPF0150
N4T40_20250	COG4974	Belongs to the 'phage' integrase family
N4T40_20360	COG1475	DNA binding
N4T40_20365	COG1192	Involved in chromosome partitioning
N4T40_20475	COG0789	Transcriptional regulator
N4T40_20485	COG0640	Transcriptional regulator
N4T40_20495	COG1230	cation diffusion facilitator family transporter
N4T40_20500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4T40_20770	COG4372	Transposase
N4T40_20780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N4T40_20805	COG2963	transposase activity
N4T40_20815	COG4372	Transposase
N4T40_20830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N4T40_20850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N4T40_20860	COG5002	protein histidine kinase activity
N4T40_20865	COG0745	RESPONSE REGULATOR receiver
N4T40_20895	COG0860	N-Acetylmuramoyl-L-alanine amidase
N4T40_20920	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N4T40_20945	COG4372	Transposase
N4T40_21025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N4T40_21105	COG2189	Belongs to the N(4) N(6)-methyltransferase family
N4T40_21115	COG1525	nuclease
N4T40_21170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N4T40_21290	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_21370	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_21445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N4T40_21590	COG3173	Aminoglycoside phosphotransferase
N4T40_21595	COG0488	(ABC) transporter
N4T40_21615	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N4T40_21620	COG3657	addiction module killer protein
N4T40_21625	COG2826	transposase and inactivated derivatives, IS30 family
N4T40_21655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N4T40_21680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N4T40_21690	COG2814	Major facilitator Superfamily
N4T40_21715	COG0657	acetylesterase activity
N4T40_21850	COG3561	AntA/AntB antirepressor
N4T40_21980	COG5410	chromosome segregation
N4T40_22070	COG0305	Participates in initiation and elongation during chromosome replication
N4T40_22100	COG3620	sequence-specific DNA binding
N4T40_22130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N4T40_22165	COG0582	viral genome integration into host DNA