locus-tag	class	description
PF515_00010	COG0592	DNA-directed DNA polymerase activity
PF515_00020	COG0187	DNA topoisomerase II activity
PF515_00030	COG0586	Pfam SNARE associated Golgi protein
PF515_00035	COG0488	(ABC) transporter
PF515_00060	COG0596	Alpha beta hydrolase
PF515_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PF515_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PF515_00110	COG0733	neurotransmitter:sodium symporter activity
PF515_00150	COG2233	PERMEase
PF515_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF515_00200	COG2814	Major facilitator Superfamily
PF515_00205	COG0656	L-ascorbic acid biosynthetic process
PF515_00210	COG0583	DNA-binding transcription factor activity
PF515_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF515_00230	COG1064	alcohol dehydrogenase
PF515_00235	COG2818	Glycosylase
PF515_00250	COG1194	a g-specific adenine glycosylase
PF515_00270	COG2983	Belongs to the UPF0260 family
PF515_00275	COG2133	pyrroloquinoline quinone binding
PF515_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PF515_00285	COG2116	formate transmembrane transporter activity
PF515_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF515_00310	COG1335	isochorismatase
PF515_00315	COG0385	Bile acid
PF515_00320	COG0534	Mate efflux family protein
PF515_00325	COG1683	Conserved Protein
PF515_00345	COG0625	glutathione transferase activity
PF515_00355	COG1113	amino acid transport
PF515_00365	COG0523	cobalamin synthesis protein
PF515_00375	COG2188	Transcriptional regulator
PF515_00405	COG0010	Belongs to the arginase family
PF515_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF515_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PF515_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PF515_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PF515_00540	COG0534	Mate efflux family protein
PF515_00545	COG0436	Aminotransferase
PF515_00550	COG2733	membrane
PF515_00565	COG2918	glutathione biosynthetic process
PF515_00580	COG1388	LysM domain
PF515_00580	COG0791	NLP P60 protein
PF515_00595	COG3150	esterase
PF515_00605	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
PF515_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF515_00630	COG2233	PERMEase
PF515_00635	COG2351	hydroxyisourate hydrolase activity
PF515_00670	COG3706	GGDEF domain
PF515_00685	COG1393	Belongs to the ArsC family
PF515_00690	COG0708	Exodeoxyribonuclease III
PF515_00710	COG0189	ligase activity
PF515_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PF515_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PF515_00755	COG4942	peptidase
PF515_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF515_00775	COG2119	membrane
PF515_00780	COG4774	siderophore transport
PF515_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF515_00785	COG0426	domain, Protein
PF515_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PF515_00830	COG1902	pentaerythritol trinitrate reductase activity
PF515_00835	COG1519	Transferase
PF515_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF515_00845	COG0668	transmembrane transport
PF515_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF515_00860	COG1335	isochorismatase
PF515_00865	COG1522	sequence-specific DNA binding
PF515_00870	COG3328	transposase activity
PF515_00895	COG0784	Response regulator, receiver
PF515_00895	COG2198	Histidine kinase
PF515_00895	COG2205	protein histidine kinase activity
PF515_00900	COG3162	membrane
PF515_00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF515_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF515_00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PF515_00940	COG1309	transcriptional regulator
PF515_00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF515_00960	COG0352	thiamine-phosphate diphosphorylase activity
PF515_00960	COG0351	phosphomethylpyrimidine kinase
PF515_00970	COG2814	Major facilitator Superfamily
PF515_00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF515_00995	COG1113	amino acid transport
PF515_01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF515_01010	COG1012	belongs to the aldehyde dehydrogenase family
PF515_01020	COG1335	isochorismatase
PF515_01050	COG2814	Major facilitator Superfamily
PF515_01055	COG0583	DNA-binding transcription factor activity
PF515_01075	COG0667	Aldo Keto reductase
PF515_01110	COG1733	regulation of RNA biosynthetic process
PF515_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF515_01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF515_01195	COG2329	Antibiotic biosynthesis monooxygenase
PF515_01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PF515_01255	COG0427	acetyl-CoA hydrolase
PF515_01280	COG0659	secondary active sulfate transmembrane transporter activity
PF515_01285	COG4221	oxidoreductase activity
PF515_01290	COG2873	o-acetylhomoserine
PF515_01295	COG0488	(ABC) transporter
PF515_01380	COG0833	amino acid
PF515_01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PF515_01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PF515_01445	COG2226	methyltransferase
PF515_01495	COG0067	glutamate synthase
PF515_01495	COG0069	glutamate synthase activity
PF515_01495	COG0070	glutamate synthase
PF515_01500	COG0493	'glutamate synthase
PF515_01510	COG1704	LemA family
PF515_01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PF515_01535	COG3307	-O-antigen
PF515_01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF515_01570	COG0194	GDP metabolic process
PF515_01620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PF515_01640	COG5380	lipid catabolic process
PF515_01645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PF515_01670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF515_01675	COG0277	FAD linked oxidase domain protein
PF515_01685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF515_01690	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF515_01705	COG1289	transmembrane transporter activity
PF515_01715	COG0628	permease
PF515_01720	COG1192	Involved in chromosome partitioning
PF515_01750	COG0833	amino acid
PF515_01755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF515_01760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF515_01770	COG1012	belongs to the aldehyde dehydrogenase family
PF515_01810	COG0583	DNA-binding transcription factor activity
PF515_01855	COG0517	IMP dehydrogenase activity
PF515_01860	COG1983	PspC domain protein
PF515_01870	COG1960	acyl-CoA dehydrogenase activity
PF515_01885	COG0408	coproporphyrinogen oxidase activity
PF515_01905	COG0513	Belongs to the DEAD box helicase family
PF515_01915	COG1127	ABC transporter
PF515_01920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PF515_01930	COG2854	intermembrane phospholipid transfer
PF515_01940	COG0598	Magnesium transport protein CorA
PF515_01950	COG0494	nUDIX hydrolase
PF515_01955	COG1040	competence protein
PF515_01960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PF515_01980	COG1946	Acyl-CoA thioesterase
PF515_01985	COG1301	dicarboxylic acid transport
PF515_02000	COG1959	2 iron, 2 sulfur cluster binding
PF515_02005	COG1017	nitric oxide dioxygenase activity
PF515_02005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF515_02010	COG0433	COG0433 Predicted ATPase
PF515_02015	COG0626	cystathionine gamma-synthase activity
PF515_02170	COG1960	acyl-CoA dehydrogenase activity
PF515_02175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PF515_02205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PF515_02210	COG0339	signal peptide processing
PF515_02215	COG0557	exoribonuclease II activity
PF515_02260	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF515_02265	COG2169	Transcriptional regulator
PF515_02270	COG0697	spore germination
PF515_02275	COG1295	ribonuclease BN
PF515_02310	COG1702	phosphate starvation-inducible protein PhoH
PF515_02320	COG0741	lytic transglycosylase activity
PF515_02320	COG1196	nuclear chromosome segregation
PF515_02320	COG0739	heme binding
PF515_02350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PF515_02355	COG1183	phosphatidylcholine synthase activity
PF515_02400	COG1960	acyl-CoA dehydrogenase activity
PF515_02405	COG1309	transcriptional regulator
PF515_02420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF515_02425	COG1960	acyl-CoA dehydrogenase activity
PF515_02445	COG2969	positive regulation of protein catabolic process
PF515_02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PF515_02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PF515_02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PF515_02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PF515_02505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF515_02510	COG1408	metallophosphoesterase
PF515_02520	COG2199	diguanylate cyclase activity
PF515_02580	COG1607	acyl-coa hydrolase
PF515_02610	COG2350	Protein conserved in bacteria
PF515_02620	COG0613	PHP domain protein
PF515_02625	COG3781	membrane
PF515_02635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PF515_02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF515_02650	COG1862	Preprotein translocase
PF515_02680	COG2205	protein histidine kinase activity
PF515_02685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PF515_02705	COG0726	polysaccharide deacetylase
PF515_02710	COG0463	Glycosyl transferase, family 2
PF515_02715	COG0438	transferase activity, transferring glycosyl groups
PF515_02780	COG0625	glutathione transferase activity
PF515_02785	COG0583	DNA-binding transcription factor activity
PF515_02790	COG1960	acyl-CoA dehydrogenase activity
PF515_02795	COG1960	acyl-CoA dehydrogenase activity
PF515_02805	COG2205	protein histidine kinase activity
PF515_02810	COG0745	RESPONSE REGULATOR receiver
PF515_02815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PF515_02835	COG2096	Adenosyltransferase
PF515_02885	COG0285	dihydrofolate synthase activity
PF515_02905	COG0450	alkyl hydroperoxide reductase
PF515_02920	COG0477	Major facilitator Superfamily
PF515_02925	COG1272	protein, Hemolysin III
PF515_02955	COG0183	Belongs to the thiolase family
PF515_02960	COG2207	Transcriptional regulator
PF515_02980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF515_03000	COG0183	Belongs to the thiolase family
PF515_03010	COG2885	chlorophyll binding
PF515_03010	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PF515_03020	COG1690	Belongs to the RtcB family
PF515_03025	COG0833	amino acid
PF515_03035	COG2233	PERMEase
PF515_03040	COG1217	gtp-binding protein TYPA
PF515_03065	COG2094	Belongs to the DNA glycosylase MPG family
PF515_03085	COG1902	pentaerythritol trinitrate reductase activity
PF515_03100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF515_03105	COG0354	folic acid binding
PF515_03115	COG3189	MarR family transcriptional regulator
PF515_03120	COG2824	Alkylphosphonate utilization operon protein PhnA
PF515_03125	COG3422	double-strand break repair
PF515_03165	COG0840	transmembrane signaling receptor activity
PF515_03185	COG5510	response to toxic substance
PF515_03195	COG2832	Protein of unknown function (DUF454)
PF515_03200	COG1376	ErfK ybiS ycfS ynhG family protein
PF515_03240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF515_03250	COG1289	transmembrane transporter activity
PF515_03255	COG2814	Major facilitator Superfamily
PF515_03275	COG1115	amino acid carrier protein
PF515_03280	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF515_03285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF515_03290	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
PF515_03330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF515_03340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF515_03345	COG1077	Cell shape determining protein MreB Mrl
PF515_03350	COG1792	Involved in formation and maintenance of cell shape
PF515_03355	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PF515_03360	COG0424	maF-like protein
PF515_03365	COG1530	ribonuclease E activity
PF515_03375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF515_03385	COG0560	Phosphoserine phosphatase
PF515_03395	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF515_03420	COG2207	Transcriptional regulator
PF515_03440	COG1113	amino acid transport
PF515_03445	COG2828	Protein conserved in bacteria
PF515_03450	COG0142	geranyltranstransferase activity
PF515_03455	COG2315	Protein conserved in bacteria
PF515_03470	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF515_03490	COG2194	sulfuric ester hydrolase activity
PF515_03495	COG0745	RESPONSE REGULATOR receiver
PF515_03500	COG0642	Histidine kinase
PF515_03510	COG0004	ammonium transporteR
PF515_03515	COG0583	DNA-binding transcription factor activity
PF515_03535	COG0525	valine-tRNA ligase activity
PF515_03545	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_03555	COG0393	Putative heavy-metal-binding
PF515_03560	COG0393	Putative heavy-metal-binding
PF515_03565	COG1538	Outer membrane efflux protein
PF515_03575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF515_03580	COG0671	phosphoesterase, PA-phosphatase related
PF515_03610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PF515_03625	COG1648	precorrin-2 dehydrogenase activity
PF515_03625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF515_03630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PF515_03635	COG1733	regulation of RNA biosynthetic process
PF515_03645	COG0531	amino acid
PF515_03660	COG0321	lipoyl(octanoyl) transferase activity
PF515_03665	COG2921	Belongs to the UPF0250 family
PF515_03705	COG2009	succinate dehydrogenase
PF515_03710	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PF515_03715	COG1053	succinate dehydrogenase
PF515_03720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PF515_03745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF515_03765	COG2354	Protein conserved in bacteria
PF515_03770	COG2321	neutral zinc metallopeptidase
PF515_03790	COG2843	Capsule synthesis protein
PF515_03805	COG0589	response to stress
PF515_03825	COG0505	Belongs to the CarA family
PF515_03850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF515_03855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PF515_03905	COG0477	Major facilitator Superfamily
PF515_03910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PF515_03925	COG1597	lipid kinase activity
PF515_03930	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF515_03960	COG0584	glycerophosphoryl diester phosphodiesterase
PF515_03980	COG0741	lytic transglycosylase activity
PF515_04000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PF515_04015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF515_04045	COG0778	Nitroreductase
PF515_04060	COG1929	Belongs to the glycerate kinase type-1 family
PF515_04065	COG0243	molybdopterin cofactor binding
PF515_04070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PF515_04075	COG3339	Conserved Protein
PF515_04085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PF515_04100	COG1113	amino acid transport
PF515_04110	COG0019	diaminopimelate decarboxylase activity
PF515_04120	COG1280	lysine exporter protein (LysE YggA)
PF515_04125	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PF515_04155	COG0463	Glycosyl transferase, family 2
PF515_04175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF515_04210	COG4591	ABC-type transport system involved in lipoprotein release permease component
PF515_04215	COG1136	(ABC) transporter
PF515_04220	COG0658	competence protein
PF515_04220	COG2333	competence protein COMEC
PF515_04230	COG0616	signal peptide processing
PF515_04230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PF515_04235	COG0596	Alpha beta hydrolase
PF515_04240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PF515_04250	COG0628	permease
PF515_04290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF515_04310	COG0823	Involved in the tonB-independent uptake of proteins
PF515_04330	COG0824	Thioesterase
PF515_04335	COG1473	amidohydrolase
PF515_04355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PF515_04355	COG0047	phosphoribosylformylglycinamidine synthase activity
PF515_04360	COG2814	Major facilitator Superfamily
PF515_04375	COG1024	Enoyl-CoA hydratase
PF515_04380	COG1051	belongs to the nudix hydrolase family
PF515_04380	COG1056	cytidyltransferase-related domain
PF515_04390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PF515_04405	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PF515_04420	COG4625	pathogenesis
PF515_04425	COG0583	DNA-binding transcription factor activity
PF515_04430	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PF515_04435	COG4208	sulfate ABC transporter
PF515_04440	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PF515_04450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PF515_04455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF515_04460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF515_04480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF515_04495	COG0681	Belongs to the peptidase S26 family
PF515_04510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PF515_04520	COG1381	Involved in DNA repair and RecF pathway recombination
PF515_04525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PF515_04535	COG4221	oxidoreductase activity
PF515_04565	COG0436	Aminotransferase
PF515_04585	COG0556	nucleotide-excision repair
PF515_04640	COG2070	2-Nitropropane dioxygenase
PF515_04670	COG1215	transferase activity, transferring glycosyl groups
PF515_04685	COG0415	Belongs to the DNA photolyase family
PF515_04695	COG1252	NADH dehydrogenase
PF515_04700	COG1686	Belongs to the peptidase S11 family
PF515_04715	COG1187	pseudouridine synthase activity
PF515_04740	COG0477	Major facilitator Superfamily
PF515_04745	COG0583	DNA-binding transcription factor activity
PF515_04750	COG1823	symporter activity
PF515_04770	COG0612	Peptidase, M16
PF515_04795	COG0352	thiamine-phosphate diphosphorylase activity
PF515_04830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF515_04845	COG1309	transcriptional regulator
PF515_04855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF515_04860	COG0076	glutamate decarboxylase activity
PF515_04870	COG1522	sequence-specific DNA binding
PF515_04875	COG3961	Belongs to the TPP enzyme family
PF515_04880	COG1113	amino acid transport
PF515_04885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PF515_04890	COG0573	inorganic phosphate transmembrane transporter activity
PF515_04900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF515_04905	COG0616	signal peptide processing
PF515_04915	COG3328	transposase activity
PF515_04945	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PF515_04950	COG1686	Belongs to the peptidase S11 family
PF515_04975	COG0583	DNA-binding transcription factor activity
PF515_04980	COG1067	ATP-dependent peptidase activity
PF515_05025	COG1966	Carbon starvation protein
PF515_05030	COG2879	small protein
PF515_05065	COG2508	Transcriptional regulator
PF515_05065	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
PF515_05085	COG1113	amino acid transport
PF515_05090	COG0583	DNA-binding transcription factor activity
PF515_05095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF515_05100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF515_05110	COG1012	belongs to the aldehyde dehydrogenase family
PF515_05120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF515_05125	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PF515_05125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF515_05160	COG2814	Major facilitator Superfamily
PF515_05165	COG4948	Mandelate Racemase Muconate Lactonizing
PF515_05175	COG1309	transcriptional regulator
PF515_05195	COG1741	Belongs to the pirin family
PF515_05205	COG2964	Protein conserved in bacteria
PF515_05220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF515_05230	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF515_05235	COG4605	iron ion homeostasis
PF515_05240	COG4604	ABC transporter, ATP-binding protein
PF515_05245	COG4607	ABC-type enterochelin transport system periplasmic component
PF515_05250	COG4774	siderophore transport
PF515_05260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF515_05265	COG1021	2,3-dihydroxybenzoate-AMP ligase
PF515_05270	COG3433	isochorismatase activity
PF515_05270	COG1535	isochorismatase
PF515_05285	COG1132	(ABC) transporter
PF515_05290	COG1132	(ABC) transporter
PF515_05295	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
PF515_05305	COG1169	isochorismate synthase
PF515_05320	COG3739	integral membrane protein
PF515_05345	COG0302	gtp cyclohydrolase
PF515_05355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PF515_05385	COG0308	aminopeptidase N
PF515_05390	COG0512	Glutamine amidotransferase of anthranilate synthase
PF515_05405	COG0174	glutamine synthetase
PF515_05415	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PF515_05450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF515_05455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PF515_05460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF515_05480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF515_05485	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PF515_05490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PF515_05505	COG1960	acyl-CoA dehydrogenase activity
PF515_05510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF515_05515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF515_05525	COG2223	nitrite transmembrane transporter activity
PF515_05535	COG0024	Methionine aminopeptidase
PF515_05540	COG0052	Belongs to the universal ribosomal protein uS2 family
PF515_05555	COG2207	Transcriptional regulator
PF515_05580	COG2951	lytic endotransglycosylase activity
PF515_05585	COG0772	Belongs to the SEDS family
PF515_05600	COG0842	Transport permease protein
PF515_05605	COG1131	(ABC) transporter
PF515_05650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF515_05665	COG4215	(ABC) transporter
PF515_05670	COG4160	amino acid transport
PF515_05675	COG4598	ABC transporter
PF515_05685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF515_05690	COG0826	peptidase U32
PF515_05695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF515_05710	COG1720	tRNA m6t6A37 methyltransferase activity
PF515_05720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PF515_05735	COG0642	Histidine kinase
PF515_05745	COG0494	nUDIX hydrolase
PF515_05755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF515_05760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF515_05765	COG3139	Protein of unknown function (DUF1315)
PF515_05770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PF515_05775	COG1301	dicarboxylic acid transport
PF515_05780	COG1960	acyl-CoA dehydrogenase activity
PF515_05785	COG2819	hydrolase of the alpha beta superfamily
PF515_05795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PF515_05805	COG2195	Cleaves the N-terminal amino acid of tripeptides
PF515_05810	COG1234	tRNA 3'-trailer cleavage
PF515_05840	COG2363	Small membrane protein
PF515_05865	COG0513	Belongs to the DEAD box helicase family
PF515_05875	COG0778	Nitroreductase
PF515_05905	COG1286	toxin biosynthetic process
PF515_05930	COG4783	chaperone-mediated protein folding
PF515_05935	COG1610	YqeY-like protein
PF515_06035	COG3111	PFAM Bacterial OB fold (BOF) protein
PF515_06060	COG3243	poly(R)-hydroxyalkanoic acid synthase
PF515_06065	COG0786	glutamate:sodium symporter activity
PF515_06075	COG2186	Transcriptional regulator
PF515_06125	COG0477	Major facilitator Superfamily
PF515_06155	COG2985	domain, Protein
PF515_06165	COG2995	paraquat-inducible protein a
PF515_06170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PF515_06170	COG3008	intermembrane lipid transfer
PF515_06200	COG0488	(ABC) transporter
PF515_06205	COG3173	Aminoglycoside phosphotransferase
PF515_06215	COG2433	Pfam Transposase IS66
PF515_06255	COG1301	dicarboxylic acid transport
PF515_06265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF515_06270	COG2011	ABC-type metal ion transport system permease component
PF515_06275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF515_06280	COG1464	Belongs to the NlpA lipoprotein family
PF515_06285	COG0151	Belongs to the GarS family
PF515_06290	COG0138	bifunctional purine biosynthesis protein purh
PF515_06295	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PF515_06325	COG2308	Evidence 4 Homologs of previously reported genes of
PF515_06335	COG1305	Transglutaminase-like
PF515_06345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF515_06350	COG0305	Participates in initiation and elongation during chromosome replication
PF515_06375	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PF515_06385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF515_06390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF515_06415	COG1649	PFAM Uncharacterised BCR, COG1649
PF515_06415	COG0726	polysaccharide deacetylase
PF515_06420	COG1215	transferase activity, transferring glycosyl groups
PF515_06425	COG3658	cytochrome
PF515_06435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF515_06450	COG0583	DNA-binding transcription factor activity
PF515_06470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF515_06475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF515_06505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF515_06510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF515_06535	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PF515_06540	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
PF515_06550	COG2205	protein histidine kinase activity
PF515_06555	COG0745	RESPONSE REGULATOR receiver
PF515_06560	COG0174	glutamine synthetase
PF515_06580	COG0729	surface antigen
PF515_06605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF515_06610	COG2814	Major facilitator Superfamily
PF515_06625	COG0583	DNA-binding transcription factor activity
PF515_06640	COG1187	pseudouridine synthase activity
PF515_06660	COG0802	atpase or kinase
PF515_06665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PF515_06675	COG1923	regulation of RNA biosynthetic process
PF515_06680	COG0697	spore germination
PF515_06695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF515_06705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF515_06710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF515_06710	COG0519	Catalyzes the synthesis of GMP from XMP
PF515_06715	COG4302	ethanolamine ammonia-lyase activity
PF515_06720	COG4303	Ethanolamine ammonia lyase large subunit
PF515_06725	COG0531	amino acid
PF515_06745	COG1454	alcohol dehydrogenase
PF515_06750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF515_06760	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
PF515_06780	COG0308	aminopeptidase N
PF515_06810	COG1605	Chorismate mutase
PF515_06830	COG1309	transcriptional regulator
PF515_06840	COG0668	transmembrane transport
PF515_06875	COG4773	Receptor
PF515_06895	COG0488	(ABC) transporter
PF515_06900	COG0589	response to stress
PF515_06925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PF515_06935	COG3135	benzoate transporter
PF515_06940	COG1522	sequence-specific DNA binding
PF515_06950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PF515_06955	COG0583	DNA-binding transcription factor activity
PF515_06965	COG0183	Belongs to the thiolase family
PF515_06975	COG2030	dehydratase
PF515_06980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF515_06995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PF515_07005	COG0824	Thioesterase
PF515_07010	COG1454	alcohol dehydrogenase
PF515_07020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF515_07040	COG0069	glutamate synthase activity
PF515_07235	COG5410	chromosome segregation
PF515_07365	COG0739	heme binding
PF515_07410	COG2194	sulfuric ester hydrolase activity
PF515_07450	COG0006	proline dipeptidase activity
PF515_07455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF515_07460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF515_07480	COG1279	arginine transmembrane transporter activity
PF515_07485	COG0583	DNA-binding transcription factor activity
PF515_07525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF515_07530	COG1388	LysM domain
PF515_07530	COG0741	lytic transglycosylase activity
PF515_07530	COG0741	lytic transglycosylase activity
PF515_07530	COG1388	LysM domain
PF515_07540	COG4174	ABC transporter (Permease)
PF515_07545	COG4239	(ABC) transporter, permease
PF515_07550	COG4172	Belongs to the ABC transporter superfamily
PF515_07570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF515_07580	COG3706	GGDEF domain
PF515_07580	COG2203	Gaf domain
PF515_07580	COG5001	Diguanylate cyclase
PF515_07580	COG4251	negative regulation of phosphorylation
PF515_07590	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF515_07590	COG1902	pentaerythritol trinitrate reductase activity
PF515_07630	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PF515_07655	COG1309	transcriptional regulator
PF515_07660	COG1741	Belongs to the pirin family
PF515_07675	COG2072	flavoprotein involved in K transport
PF515_07685	COG2252	PERMEase
PF515_07690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PF515_07695	COG3038	cytochrome b561
PF515_07705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PF515_07715	COG0527	aspartate kinase activity
PF515_07725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF515_07735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PF515_07750	COG0667	Aldo Keto reductase
PF515_07770	COG1765	OsmC-like protein
PF515_07785	COG0542	response to heat
PF515_07820	COG2885	chlorophyll binding
PF515_07830	COG0625	glutathione transferase activity
PF515_07835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PF515_07855	COG3634	alkyl hydroperoxide reductase activity
PF515_07865	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PF515_07875	COG0450	alkyl hydroperoxide reductase
PF515_07880	COG1643	Atp-dependent helicase
PF515_07895	COG2814	Major facilitator Superfamily
PF515_07900	COG3135	benzoate transporter
PF515_07905	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_07910	COG0543	2 iron, 2 sulfur cluster binding
PF515_07910	COG0633	Ferredoxin
PF515_07915	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
PF515_07920	COG4638	Rieske (2fe-2S)
PF515_07930	COG0583	DNA-binding transcription factor activity
PF515_07980	COG1570	exodeoxyribonuclease VII activity
PF515_08010	COG1280	lysine exporter protein (LysE YggA)
PF515_08015	COG1278	Cold shock
PF515_08050	COG2814	Major facilitator Superfamily
PF515_08085	COG0517	IMP dehydrogenase activity
PF515_08085	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PF515_08090	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PF515_08100	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PF515_08105	COG1137	ATPase activity
PF515_08110	COG1538	Outer membrane efflux protein
PF515_08140	COG4122	O-methyltransferase activity
PF515_08150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PF515_08165	COG1522	sequence-specific DNA binding
PF515_08170	COG5006	permease, DMT superfamily
PF515_08180	COG1560	Kdo2-lipid A biosynthetic process
PF515_08195	COG2814	Major facilitator Superfamily
PF515_08215	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF515_08265	COG0583	DNA-binding transcription factor activity
PF515_08270	COG1914	H( )-stimulated, divalent metal cation uptake system
PF515_08290	COG4770	biotin carboxylase activity
PF515_08295	COG0038	chloride channel
PF515_08315	COG1309	transcriptional regulator
PF515_08325	COG1063	alcohol dehydrogenase
PF515_08340	COG0439	Biotin carboxylase
PF515_08345	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF515_08365	COG0864	Transcriptional regulator
PF515_08375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF515_08380	COG1116	anion transmembrane transporter activity
PF515_08495	COG0590	tRNA wobble adenosine to inosine editing
PF515_08500	COG2807	transmembrane transport
PF515_08515	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PF515_08530	COG0789	Transcriptional regulator
PF515_08540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF515_08560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF515_08570	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF515_08585	COG1012	belongs to the aldehyde dehydrogenase family
PF515_08590	COG0531	amino acid
PF515_08595	COG1760	l-serine dehydratase
PF515_08600	COG1012	belongs to the aldehyde dehydrogenase family
PF515_08600	COG2030	dehydratase
PF515_08605	COG3396	Phenylacetate-CoA oxygenase
PF515_08610	COG3460	Phenylacetate-CoA oxygenase
PF515_08615	COG3396	Phenylacetate-CoA oxygenase
PF515_08620	COG2151	metal-sulfur cluster biosynthetic enzyme
PF515_08625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF515_08630	COG1024	Enoyl-CoA hydratase
PF515_08635	COG1024	Enoyl-CoA hydratase
PF515_08640	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF515_08645	COG0183	Belongs to the thiolase family
PF515_08650	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PF515_08655	COG3327	negative regulation of DNA-templated transcription, initiation
PF515_08665	COG2050	protein possibly involved in aromatic compounds catabolism
PF515_08695	COG0753	catalase activity
PF515_08700	COG3038	cytochrome b561
PF515_08720	COG2267	carboxylic ester hydrolase activity
PF515_08725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF515_08730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF515_08735	COG1012	belongs to the aldehyde dehydrogenase family
PF515_08745	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF515_08755	COG1012	belongs to the aldehyde dehydrogenase family
PF515_08760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF515_08765	COG0583	DNA-binding transcription factor activity
PF515_08775	COG1414	Transcriptional regulator
PF515_08780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF515_08790	COG1840	ABC-type Fe3 transport system, periplasmic component
PF515_08795	COG3842	ATPase activity
PF515_08810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PF515_08815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF515_08820	COG2814	Major facilitator Superfamily
PF515_08825	COG1960	acyl-CoA dehydrogenase activity
PF515_08840	COG1024	Enoyl-CoA hydratase
PF515_08850	COG2814	Major facilitator Superfamily
PF515_08860	COG0183	Belongs to the thiolase family
PF515_08865	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF515_08870	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_08875	COG1024	Enoyl-CoA hydratase
PF515_08880	COG1960	acyl-CoA dehydrogenase activity
PF515_08885	COG2814	Major facilitator Superfamily
PF515_08890	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF515_08895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF515_08905	COG2814	Major facilitator Superfamily
PF515_08915	COG1960	acyl-CoA dehydrogenase activity
PF515_08930	COG0583	DNA-binding transcription factor activity
PF515_08940	COG4770	biotin carboxylase activity
PF515_08945	COG1024	Enoyl-CoA hydratase
PF515_08950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF515_08955	COG1960	acyl-CoA dehydrogenase activity
PF515_08960	COG1309	transcriptional regulator
PF515_08965	COG0318	PFAM AMP-dependent synthetase and ligase
PF515_08985	COG0583	DNA-binding transcription factor activity
PF515_09035	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_09055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PF515_09075	COG0784	Response regulator, receiver
PF515_09075	COG2205	protein histidine kinase activity
PF515_09095	COG0765	amino acid transport
PF515_09100	COG0765	amino acid transport
PF515_09105	COG1126	abc transporter atp-binding protein
PF515_09110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF515_09115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF515_09130	COG1280	lysine exporter protein (LysE YggA)
PF515_09140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF515_09145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF515_09150	COG1045	serine acetyltransferase
PF515_09165	COG0583	DNA-binding transcription factor activity
PF515_09170	COG0625	glutathione transferase activity
PF515_09175	COG0625	glutathione transferase activity
PF515_09180	COG0583	DNA-binding transcription factor activity
PF515_09190	COG1346	cytolysis
PF515_09210	COG2814	Major facilitator Superfamily
PF515_09220	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
PF515_09225	COG3052	prosthetic group binding
PF515_09245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF515_09265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF515_09275	COG1294	oxidase, subunit
PF515_09280	COG1271	oxidase subunit
PF515_09300	COG0477	Major facilitator Superfamily
PF515_09310	COG4521	taurine ABC transporter
PF515_09315	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PF515_09320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF515_09325	COG2175	clavaminate synthase activity
PF515_09335	COG1953	Uracil, thiamine, allantoin
PF515_09345	COG0583	DNA-binding transcription factor activity
PF515_09355	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PF515_09370	COG0640	Transcriptional regulator
PF515_09375	COG0798	PFAM Bile acid sodium symporter
PF515_09380	COG0583	DNA-binding transcription factor activity
PF515_09395	COG3634	alkyl hydroperoxide reductase activity
PF515_09435	COG0436	Aminotransferase
PF515_09445	COG0386	Belongs to the glutathione peroxidase family
PF515_09485	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF515_09510	COG0012	GTP binding
PF515_09515	COG2011	ABC-type metal ion transport system permease component
PF515_09520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF515_09530	COG1464	Belongs to the NlpA lipoprotein family
PF515_09560	COG0765	amino acid transport
PF515_09565	COG0765	amino acid transport
PF515_09570	COG1126	abc transporter atp-binding protein
PF515_09580	COG1522	sequence-specific DNA binding
PF515_09595	COG1309	transcriptional regulator
PF515_09615	COG0583	DNA-binding transcription factor activity
PF515_09625	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF515_09635	COG0697	spore germination
PF515_09660	COG3121	Chaperone
PF515_09665	COG3539	Fimbrial protein
PF515_09690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PF515_09690	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PF515_09735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PF515_09745	COG2353	YceI-like domain
PF515_09755	COG3698	Phosphodiester glycosidase
PF515_09770	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PF515_09775	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PF515_09775	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PF515_09775	COG0506	proline dehydrogenase activity
PF515_09785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF515_09790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PF515_09810	COG1132	(ABC) transporter
PF515_09815	COG3122	Protein conserved in bacteria
PF515_09820	COG3619	membrane
PF515_09835	COG0640	Transcriptional regulator
PF515_09845	COG2850	peptidyl-arginine hydroxylation
PF515_09850	COG0424	maF-like protein
PF515_09870	COG0191	fructose-bisphosphate aldolase activity
PF515_09875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF515_09890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PF515_09900	COG1192	Involved in chromosome partitioning
PF515_09905	COG1475	DNA binding
PF515_09910	COG0811	peptide transport
PF515_09920	COG1132	(ABC) transporter
PF515_09925	COG1663	tetraacyldisaccharide 4'-kinase activity
PF515_09945	COG0084	hydrolase, TatD family'
PF515_10010	COG0776	regulation of translation
PF515_10055	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PF515_10060	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PF515_10110	COG0339	signal peptide processing
PF515_10120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF515_10155	COG0702	epimerase
PF515_10160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PF515_10180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PF515_10210	COG0316	Belongs to the HesB IscA family
PF515_10215	COG0822	iron-sulfur transferase activity
PF515_10240	COG0776	regulation of translation
PF515_10245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF515_10250	COG2207	Transcriptional regulator
PF515_10255	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF515_10260	COG1960	acyl-CoA dehydrogenase activity
PF515_10265	COG1960	acyl-CoA dehydrogenase activity
PF515_10280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PF515_10300	COG4264	IucA IucC family
PF515_10305	COG4264	IucA IucC family
PF515_10345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF515_10360	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PF515_10380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PF515_10385	COG0730	response to heat
PF515_10405	COG4773	Receptor
PF515_10410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF515_10425	COG1131	(ABC) transporter
PF515_10430	COG0842	Transport permease protein
PF515_10435	COG0842	Transport permease protein
PF515_10490	COG2226	methyltransferase
PF515_10515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PF515_10550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF515_10560	COG0133	tryptophan synthase activity
PF515_10575	COG3706	GGDEF domain
PF515_10590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF515_10595	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF515_10600	COG0022	dehydrogenase e1 component
PF515_10605	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF515_10610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF515_10620	COG1063	alcohol dehydrogenase
PF515_10625	COG3781	membrane
PF515_10635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF515_10635	COG3453	Protein conserved in bacteria
PF515_10650	COG0730	response to heat
PF515_10665	COG3708	Transcriptional regulator
PF515_10665	COG2207	Transcriptional regulator
PF515_10670	COG1733	regulation of RNA biosynthetic process
PF515_10675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF515_10685	COG2188	Transcriptional regulator
PF515_10700	COG4521	taurine ABC transporter
PF515_10705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF515_10725	COG0477	Major facilitator Superfamily
PF515_10740	COG1027	Aspartate ammonia-lyase
PF515_10755	COG0583	DNA-binding transcription factor activity
PF515_10760	COG0583	DNA-binding transcription factor activity
PF515_10765	COG0183	Belongs to the thiolase family
PF515_10770	COG2031	fatty acid transporter
PF515_10775	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF515_10785	COG0583	DNA-binding transcription factor activity
PF515_10795	COG2610	gluconate transmembrane transporter activity
PF515_10800	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_10810	COG2207	Transcriptional regulator
PF515_10825	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_10850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF515_10850	COG0543	2 iron, 2 sulfur cluster binding
PF515_10855	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
PF515_10860	COG4638	Rieske (2fe-2S)
PF515_10870	COG0725	ABC transporter, periplasmic molybdate-binding protein
PF515_10875	COG4149	molybdate abc transporter
PF515_10880	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PF515_10885	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_10890	COG1535	isochorismatase
PF515_10890	COG3433	isochorismatase activity
PF515_10950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF515_10965	COG0753	catalase activity
PF515_10975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PF515_11005	COG3539	Fimbrial protein
PF515_11025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF515_11045	COG2072	flavoprotein involved in K transport
PF515_11055	COG1538	Outer membrane efflux protein
PF515_11060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF515_11065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF515_11070	COG0745	RESPONSE REGULATOR receiver
PF515_11075	COG2205	protein histidine kinase activity
PF515_11085	COG2207	Transcriptional regulator
PF515_11100	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_11150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PF515_11270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF515_11290	COG1120	ATPase activity
PF515_11295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF515_11305	COG1064	alcohol dehydrogenase
PF515_11320	COG2207	Transcriptional regulator
PF515_11325	COG2084	Dehydrogenase
PF515_11335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF515_11340	COG0583	DNA-binding transcription factor activity
PF515_11350	COG0129	dihydroxy-acid dehydratase activity
PF515_11355	COG1012	belongs to the aldehyde dehydrogenase family
PF515_11370	COG1566	PFAM secretion protein HlyD family protein
PF515_11405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PF515_11435	COG0583	DNA-binding transcription factor activity
PF515_11450	COG2188	Transcriptional regulator
PF515_11480	COG3210	domain, Protein
PF515_11485	COG2831	hemolysin activation secretion protein
PF515_11495	COG1473	amidohydrolase
PF515_11505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF515_11505	COG0475	glutathione-regulated potassium exporter activity
PF515_11515	COG0583	DNA-binding transcription factor activity
PF515_11520	COG1335	isochorismatase
PF515_11530	COG1309	transcriptional regulator
PF515_11560	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF515_11570	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF515_11570	COG1902	pentaerythritol trinitrate reductase activity
PF515_11575	COG1846	Transcriptional regulator
PF515_11595	COG0753	catalase activity
PF515_11610	COG1012	belongs to the aldehyde dehydrogenase family
PF515_11625	COG3162	membrane
PF515_11635	COG3829	transcription factor binding
PF515_11640	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_11645	COG1960	acyl-CoA dehydrogenase activity
PF515_11665	COG1012	belongs to the aldehyde dehydrogenase family
PF515_11685	COG2186	Transcriptional regulator
PF515_11695	COG0583	DNA-binding transcription factor activity
PF515_11700	COG4948	Mandelate Racemase Muconate Lactonizing
PF515_11705	COG4829	muconolactone delta-isomerase
PF515_11715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF515_11720	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF515_11725	COG0183	Belongs to the thiolase family
PF515_11730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF515_11740	COG1012	belongs to the aldehyde dehydrogenase family
PF515_11750	COG3733	amine oxidase
PF515_11760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF515_11770	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_11780	COG4638	Rieske (2fe-2S)
PF515_11800	COG0154	amidase activity
PF515_11810	COG2814	Major facilitator Superfamily
PF515_11835	COG1960	acyl-CoA dehydrogenase activity
PF515_11840	COG0583	DNA-binding transcription factor activity
PF515_11845	COG1414	Transcriptional regulator
PF515_11860	COG2391	methyltransferase activity
PF515_11870	COG4993	Dehydrogenase
PF515_11875	COG3659	wide pore channel activity
PF515_11880	COG3420	alginic acid biosynthetic process
PF515_11885	COG0710	3-dehydroquinate dehydratase activity
PF515_11890	COG3485	protocatechuate 3,4-dioxygenase
PF515_11895	COG3485	protocatechuate 3,4-dioxygenase
PF515_11900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF515_11905	COG2271	Major facilitator Superfamily
PF515_11910	COG0596	Alpha beta hydrolase
PF515_11915	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PF515_11920	COG0183	Belongs to the thiolase family
PF515_11925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF515_11930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF515_11940	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PF515_11945	COG2323	membrane
PF515_11990	COG1902	pentaerythritol trinitrate reductase activity
PF515_11990	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF515_12015	COG0542	response to heat
PF515_12020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PF515_12050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF515_12055	COG0569	domain protein
PF515_12060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PF515_12075	COG4774	siderophore transport
PF515_12080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF515_12090	COG1585	Membrane protein implicated in regulation of membrane protease activity
PF515_12110	COG1294	oxidase, subunit
PF515_12115	COG4890	Cyd operon protein YbgT
PF515_12130	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
PF515_12140	COG0552	protein localization to endoplasmic reticulum
PF515_12165	COG0517	IMP dehydrogenase activity
PF515_12165	COG0516	GMP reductase activity
PF515_12170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF515_12175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PF515_12185	COG0583	DNA-binding transcription factor activity
PF515_12190	COG0024	Methionine aminopeptidase
PF515_12220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF515_12220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PF515_12225	COG1105	Belongs to the carbohydrate kinase PfkB family
PF515_12230	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PF515_12230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF515_12230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF515_12250	COG3300	MHYT domain
PF515_12250	COG5001	Diguanylate cyclase
PF515_12265	COG2135	peptidase activity
PF515_12270	COG0659	secondary active sulfate transmembrane transporter activity
PF515_12290	COG1113	amino acid transport
PF515_12300	COG1522	sequence-specific DNA binding
PF515_12325	COG1011	Hydrolase
PF515_12330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PF515_12340	COG2137	regulation of response to DNA damage stimulus
PF515_12355	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF515_12390	COG0575	Belongs to the CDS family
PF515_12395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PF515_12415	COG3852	Histidine kinase
PF515_12420	COG2204	response regulator
PF515_12475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF515_12480	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PF515_12500	COG0697	spore germination
PF515_12505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF515_12515	COG0303	'Molybdopterin
PF515_12520	COG0315	cyclic pyranopterin monophosphate synthase activity
PF515_12520	COG0521	Mo-molybdopterin cofactor biosynthetic process
PF515_12535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PF515_12540	COG0243	molybdopterin cofactor binding
PF515_12550	COG0243	molybdopterin cofactor binding
PF515_12555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF515_12560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF515_12560	COG2146	nitrite reductase [NAD(P)H] activity
PF515_12570	COG0745	RESPONSE REGULATOR receiver
PF515_12575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF515_12575	COG1116	anion transmembrane transporter activity
PF515_12595	COG0511	ligase activity, forming carbon-carbon bonds
PF515_12610	COG2814	Major facilitator Superfamily
PF515_13015	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PF515_13040	COG3384	dioxygenase
PF515_13050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF515_13055	COG2878	Part of a membrane complex involved in electron transport
PF515_13060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PF515_13085	COG0768	penicillin binding
PF515_13090	COG0742	ribosomal rna small subunit methyltransferase
PF515_13105	COG0830	nickel cation binding
PF515_13115	COG0804	urea catabolic process
PF515_13155	COG1253	flavin adenine dinucleotide binding
PF515_13160	COG2851	Citrate transporter
PF515_13215	COG1773	rubredoxin
PF515_13220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF515_13230	COG0583	DNA-binding transcription factor activity
PF515_13255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PF515_13260	COG4181	ATPase activity
PF515_13305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PF515_13325	COG0306	phosphate transporter
PF515_13335	COG3958	Transketolase
PF515_13340	COG3959	Transketolase, thiamine diphosphate binding domain
PF515_13345	COG2271	Major facilitator Superfamily
PF515_13350	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_13355	COG0583	DNA-binding transcription factor activity
PF515_13370	COG2223	nitrite transmembrane transporter activity
PF515_13375	COG2207	Transcriptional regulator
PF515_13380	COG2066	Belongs to the glutaminase family
PF515_13385	COG0242	peptide deformylase activity
PF515_13390	COG0477	Major facilitator Superfamily
PF515_13400	COG0028	Belongs to the TPP enzyme family
PF515_13415	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_13420	COG2267	carboxylic ester hydrolase activity
PF515_13430	COG2271	Major facilitator Superfamily
PF515_13435	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF515_13445	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_13465	COG1414	Transcriptional regulator
PF515_13480	COG1024	Enoyl-CoA hydratase
PF515_13490	COG1215	transferase activity, transferring glycosyl groups
PF515_13495	COG0726	polysaccharide deacetylase
PF515_13495	COG1649	PFAM Uncharacterised BCR, COG1649
PF515_13505	COG4681	YaeQ
PF515_13515	COG0523	cobalamin synthesis protein
PF515_13525	COG1607	acyl-coa hydrolase
PF515_13535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF515_13540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF515_13545	COG1309	transcriptional regulator
PF515_13570	COG2040	homocysteine
PF515_13575	COG0531	amino acid
PF515_13630	COG1595	DNA-templated transcription, initiation
PF515_13640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF515_13645	COG0477	Major facilitator Superfamily
PF515_13665	COG0084	hydrolase, TatD family'
PF515_13700	COG0629	single-stranded DNA binding
PF515_13755	COG0582	viral genome integration into host DNA
PF515_13855	COG0592	DNA-directed DNA polymerase activity
PF515_13895	COG2026	Addiction module toxin, RelE StbE family
PF515_14110	COG1484	DNA-dependent DNA replication
PF515_14200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF515_14270	COG0405	Gamma-glutamyltransferase
PF515_14275	COG2814	Major facilitator Superfamily
PF515_14285	COG2050	protein possibly involved in aromatic compounds catabolism
PF515_14300	COG1090	epimerase
PF515_14320	COG0420	3'-5' exonuclease activity
PF515_14345	COG0735	belongs to the Fur family
PF515_14350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PF515_14370	COG0121	glutamine amidotransferase
PF515_14385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF515_14395	COG0210	DNA helicase
PF515_14400	COG2885	chlorophyll binding
PF515_14405	COG0204	Acyl-transferase
PF515_14420	COG2894	cell division
PF515_14445	COG1280	lysine exporter protein (LysE YggA)
PF515_14450	COG1674	ftsk spoiiie
PF515_14450	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PF515_14455	COG0492	ferredoxin-NADP+ reductase activity
PF515_14460	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PF515_14470	COG0456	acetyltransferase
PF515_14515	COG1981	membrane
PF515_14530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PF515_14530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF515_14550	COG1012	belongs to the aldehyde dehydrogenase family
PF515_14560	COG0657	acetylesterase activity
PF515_14570	COG0473	3-isopropylmalate dehydrogenase activity
PF515_14575	COG0583	DNA-binding transcription factor activity
PF515_14595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF515_14620	COG0564	pseudouridine synthase activity
PF515_14630	COG0358	DNA primase activity
PF515_14645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PF515_14675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF515_14705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PF515_14715	COG0352	thiamine-phosphate diphosphorylase activity
PF515_14715	COG0351	phosphomethylpyrimidine kinase
PF515_14715	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF515_14720	COG1652	LysM domain
PF515_14745	COG1399	metal-binding, possibly nucleic acid-binding protein
PF515_14750	COG3101	peptidyl-lysine hydroxylation
PF515_14755	COG0009	L-threonylcarbamoyladenylate synthase
PF515_14760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PF515_14765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PF515_14780	COG4106	trans-aconitate 2-methyltransferase activity
PF515_14795	COG0596	Alpha beta hydrolase
PF515_14795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF515_14795	COG2226	methyltransferase
PF515_14800	COG1877	trehalose-phosphatase activity
PF515_14805	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
PF515_14810	COG2223	nitrite transmembrane transporter activity
PF515_14830	COG1196	nuclear chromosome segregation
PF515_14840	COG0730	response to heat
PF515_14855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PF515_14865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF515_14915	COG0489	protein tyrosine kinase activity
PF515_14925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF515_14925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF515_14955	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PF515_14960	COG2081	HI0933 family
PF515_14970	COG0668	transmembrane transport
PF515_14990	COG0583	DNA-binding transcription factor activity
PF515_15010	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PF515_15015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF515_15045	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PF515_15085	COG0745	RESPONSE REGULATOR receiver
PF515_15105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF515_15115	COG2205	protein histidine kinase activity
PF515_15185	COG4993	Dehydrogenase
PF515_15210	COG0384	phenazine biosynthesis protein PhzF
PF515_15235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF515_15250	COG0583	DNA-binding transcription factor activity
PF515_15290	COG0583	DNA-binding transcription factor activity
PF515_15305	COG0583	DNA-binding transcription factor activity
PF515_15310	COG1053	succinate dehydrogenase
PF515_15320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PF515_15325	COG2814	Major facilitator Superfamily
PF515_15330	COG1960	acyl-CoA dehydrogenase activity
PF515_15335	COG0583	DNA-binding transcription factor activity
PF515_15340	COG1063	alcohol dehydrogenase
PF515_15370	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PF515_15375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PF515_15380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF515_15395	COG3667	copper resistance
PF515_15400	COG2132	Multicopper oxidase
PF515_15410	COG0561	phosphatase activity
PF515_15415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PF515_15440	COG1214	PFAM Peptidase M22, glycoprotease
PF515_15490	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF515_15500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PF515_15505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PF515_15510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF515_15570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF515_15580	COG1846	Transcriptional regulator
PF515_15585	COG1764	response to oxidative stress
PF515_15635	COG0037	tRNA processing
PF515_15645	COG0248	Ppx GppA phosphatase
PF515_15675	COG0072	phenylalanine-tRNA ligase activity
PF515_15720	COG1238	metal cluster binding
PF515_15725	COG0625	glutathione transferase activity
PF515_15740	COG0318	PFAM AMP-dependent synthetase and ligase
PF515_15745	COG3028	Belongs to the UPF0307 family
PF515_15750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF515_15770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PF515_15775	COG0617	tRNA 3'-terminal CCA addition
PF515_15780	COG1555	photosystem II stabilization
PF515_15785	COG3956	TIGRFAM MazG family protein
PF515_15795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF515_15815	COG0784	Response regulator, receiver
PF515_15815	COG2205	protein histidine kinase activity
PF515_15815	COG5002	protein histidine kinase activity
PF515_15820	COG1024	Enoyl-CoA hydratase
PF515_15825	COG2084	Dehydrogenase
PF515_15830	COG3622	Belongs to the hyi family
PF515_15860	COG0697	spore germination
PF515_15870	COG2814	Major facilitator Superfamily
PF515_15875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF515_15885	COG0583	DNA-binding transcription factor activity
PF515_15895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PF515_15910	COG0084	hydrolase, TatD family'
PF515_15925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PF515_15955	COG0440	acetolactate synthase activity
PF515_15960	COG0028	Belongs to the TPP enzyme family
PF515_15985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF515_15990	COG0577	efflux transmembrane transporter activity
PF515_15990	COG1136	(ABC) transporter
PF515_15995	COG1538	Outer membrane efflux protein
PF515_16010	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PF515_16015	COG1162	GTPase activity
PF515_16025	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PF515_16045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF515_16050	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_16090	COG2986	histidine ammonia-lyase
PF515_16105	COG0318	PFAM AMP-dependent synthetase and ligase
PF515_16115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF515_16160	COG1426	Protein conserved in bacteria
PF515_16195	COG0793	Belongs to the peptidase S41A family
PF515_16210	COG2267	carboxylic ester hydrolase activity
PF515_16220	COG1012	belongs to the aldehyde dehydrogenase family
PF515_16225	COG3265	gluconokinase activity
PF515_16235	COG0800	Aldolase
PF515_16250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PF515_16255	COG0280	phosphate acetyltransferase
PF515_16255	COG0857	belongs to the CobB CobQ family
PF515_16260	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
PF515_16260	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
PF515_16280	COG0740	serine-type endopeptidase activity
PF515_16290	COG4774	siderophore transport
PF515_16300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF515_16310	COG2813	Specifically methylates the guanine in position
PF515_16310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF515_16410	COG0788	formyltetrahydrofolate deformylase activity
PF515_16435	COG4651	solute:proton antiporter activity
PF515_16435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF515_16455	COG0724	RNA recognition motif
PF515_16460	COG0210	DNA helicase
PF515_16485	COG1733	regulation of RNA biosynthetic process
PF515_16495	COG2900	Belongs to the SlyX family
PF515_16500	COG0488	(ABC) transporter
PF515_16505	COG1280	lysine exporter protein (LysE YggA)
PF515_16510	COG1560	Kdo2-lipid A biosynthetic process
PF515_16520	COG1301	dicarboxylic acid transport
PF515_16575	COG0473	3-isopropylmalate dehydrogenase activity
PF515_16640	COG0583	DNA-binding transcription factor activity
PF515_16650	COG0625	glutathione transferase activity
PF515_16655	COG2378	regulation of single-species biofilm formation
PF515_16660	COG0546	phosphoglycolate phosphatase activity
PF515_16670	COG1530	ribonuclease E activity
PF515_16675	COG0318	PFAM AMP-dependent synthetase and ligase
PF515_16690	COG0583	DNA-binding transcription factor activity
PF515_16695	COG4221	oxidoreductase activity
PF515_16700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF515_16710	COG0534	Mate efflux family protein
PF515_16725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PF515_16765	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PF515_16770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF515_16785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF515_16795	COG0644	oxidoreductase
PF515_16795	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
PF515_16800	COG0425	Belongs to the sulfur carrier protein TusA family
PF515_16805	COG4535	Mg2 and Co2 transporter CorC
PF515_16815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF515_16835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF515_16840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF515_16840	COG0475	glutathione-regulated potassium exporter activity
PF515_16845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PF515_16855	COG0484	heat shock protein binding
PF515_16860	COG0789	Transcriptional regulator
PF515_16865	COG0598	Magnesium transport protein CorA
PF515_16880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF515_16885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF515_16890	COG1074	ATP-dependent DNA helicase activity
PF515_16895	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PF515_16915	COG2226	methyltransferase
PF515_16930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF515_16935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PF515_16950	COG2111	Na H antiporter
PF515_16950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF515_16955	COG1006	Multisubunit Na H antiporter MnhC subunit
PF515_16960	COG0651	ATP synthesis coupled electron transport
PF515_16965	COG1863	multisubunit Na H antiporter MnhE subunit
PF515_16970	COG2212	antiporter activity
PF515_16975	COG1320	monovalent cation:proton antiporter activity
PF515_16990	COG0195	Participates in both transcription termination and antitermination
PF515_17040	COG0237	dephospho-CoA kinase activity
PF515_17050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF515_17065	COG0497	DNA recombination
PF515_17075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PF515_17105	COG2169	Transcriptional regulator
PF515_17105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF515_17110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PF515_17175	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF515_17190	COG0326	Molecular chaperone. Has ATPase activity
PF515_17205	COG2056	Na+-H+ antiporter family
PF515_17210	COG0596	Alpha beta hydrolase
PF515_17305	COG0546	phosphoglycolate phosphatase activity
PF515_17310	COG1716	ATPase activity
PF515_17355	COG0181	hydroxymethylbilane synthase activity
PF515_17365	COG3275	phosphorelay sensor kinase activity
PF515_17385	COG1538	Outer membrane efflux protein
PF515_17390	COG0697	spore germination
PF515_17415	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF515_17420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF515_17425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF515_17430	COG0772	Belongs to the SEDS family
PF515_17455	COG4974	Belongs to the 'phage' integrase family
PF515_17460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF515_17470	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PF515_17480	COG2197	response regulator
PF515_17495	COG0793	Belongs to the peptidase S41A family
PF515_17500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PF515_17505	COG0795	lipopolysaccharide-transporting ATPase activity
PF515_17545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF515_17545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF515_17555	COG0004	ammonium transporteR
PF515_17560	COG0347	Belongs to the P(II) protein family
PF515_17635	COG1061	Type III restriction enzyme res subunit
PF515_17640	COG1002	Type II restriction enzyme, methylase subunits
PF515_17650	COG0659	secondary active sulfate transmembrane transporter activity
PF515_17655	COG0589	response to stress
PF515_17710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF515_17730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PF515_17745	COG0318	PFAM AMP-dependent synthetase and ligase
PF515_17755	COG0477	Major facilitator Superfamily
PF515_17760	COG2860	membrane
PF515_17770	COG1253	flavin adenine dinucleotide binding
PF515_17790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF515_17830	COG0655	NAD(P)H dehydrogenase (quinone) activity
PF515_17840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF515_17910	COG0758	DNA mediated transformation
PF515_17920	COG0697	spore germination
PF515_17925	COG1309	transcriptional regulator
PF515_17940	COG0386	Belongs to the glutathione peroxidase family
PF515_18005	COG1121	(ABC) transporter
PF515_18010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF515_18015	COG1280	lysine exporter protein (LysE YggA)
PF515_18020	COG2837	iron assimilation
PF515_18030	COG0281	malic enzyme
PF515_18075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF515_18075	COG0519	Catalyzes the synthesis of GMP from XMP
PF515_18080	COG4399	Belongs to the UPF0754 family
PF515_18085	COG2259	Doxx family
PF515_18090	COG0586	Pfam SNARE associated Golgi protein
PF515_18105	COG1192	Involved in chromosome partitioning
PF515_18115	COG0271	Belongs to the BolA IbaG family
PF515_18135	COG2267	carboxylic ester hydrolase activity
PF515_18155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF515_18155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PF515_18155	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF515_18155	COG3321	synthase
PF515_18160	COG1960	acyl-CoA dehydrogenase activity
PF515_18170	COG2197	response regulator
PF515_18180	COG3916	Acyl-homoserine-lactone synthase
PF515_18185	COG0477	Major facilitator Superfamily
PF515_18190	COG1024	Enoyl-CoA hydratase
PF515_18195	COG1024	Enoyl-CoA hydratase
PF515_18200	COG1960	acyl-CoA dehydrogenase activity
PF515_18205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF515_18225	COG1113	amino acid transport
PF515_18230	COG1113	amino acid transport
PF515_18235	COG0251	oxidation-reduction process
PF515_18275	COG0564	pseudouridine synthase activity
PF515_18335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PF515_18350	COG1802	Transcriptional regulator
PF515_18360	COG1448	Aminotransferase
PF515_18365	COG0277	FAD linked oxidase domain protein
PF515_18375	COG2186	Transcriptional regulator
PF515_18385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF515_18390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF515_18405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF515_18410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PF515_18435	COG0438	transferase activity, transferring glycosyl groups
PF515_18465	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PF515_18495	COG0728	peptidoglycan biosynthetic process
PF515_18500	COG3023	N-Acetylmuramoyl-L-alanine amidase
PF515_18560	COG0546	phosphoglycolate phosphatase activity
PF515_18565	COG1028	Short-chain dehydrogenase reductase Sdr
PF515_18585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF515_18590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF515_18595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF515_18600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF515_18605	COG1116	anion transmembrane transporter activity
PF515_18610	COG1309	transcriptional regulator
PF515_18615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PF515_18625	COG0196	riboflavin kinase activity
PF515_18630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PF515_18640	COG1047	Peptidyl-prolyl cis-trans
PF515_18680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PF515_18685	COG0657	acetylesterase activity
PF515_18705	COG0583	DNA-binding transcription factor activity
PF515_18735	COG2951	lytic endotransglycosylase activity
PF515_18740	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PF515_18755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PF515_18765	COG0671	phosphoesterase, PA-phosphatase related
PF515_18770	COG0861	Integral membrane protein TerC family
PF515_18780	COG0754	glutathionylspermidine amidase activity
PF515_18790	COG0402	S-adenosylhomocysteine deaminase activity
PF515_18810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF515_18815	COG1230	cation diffusion facilitator family transporter
PF515_18830	COG0706	membrane insertase activity
PF515_18900	COG1525	nuclease
PF515_18975	COG1475	DNA binding
PF515_18990	COG3853	Toxic anion resistance protein (TelA)
PF515_19095	COG0484	heat shock protein binding
PF515_19185	COG0741	lytic transglycosylase activity
PF515_19220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process