locus-tag	class	description
PF575_00010	COG0592	DNA-directed DNA polymerase activity
PF575_00020	COG0187	DNA topoisomerase II activity
PF575_00030	COG0586	Pfam SNARE associated Golgi protein
PF575_00035	COG0488	(ABC) transporter
PF575_00060	COG0596	Alpha beta hydrolase
PF575_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PF575_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PF575_00110	COG0733	neurotransmitter:sodium symporter activity
PF575_00145	COG0583	DNA-binding transcription factor activity
PF575_00150	COG2233	PERMEase
PF575_00180	COG1126	abc transporter atp-binding protein
PF575_00200	COG2188	Transcriptional regulator
PF575_00210	COG0523	cobalamin synthesis protein
PF575_00220	COG1113	amino acid transport
PF575_00230	COG0625	glutathione transferase activity
PF575_00250	COG1683	Conserved Protein
PF575_00260	COG0385	Bile acid
PF575_00265	COG1335	isochorismatase
PF575_00270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF575_00290	COG2116	formate transmembrane transporter activity
PF575_00295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PF575_00300	COG2133	pyrroloquinoline quinone binding
PF575_00305	COG2983	Belongs to the UPF0260 family
PF575_00325	COG1194	a g-specific adenine glycosylase
PF575_00340	COG2818	Glycosylase
PF575_00345	COG1064	alcohol dehydrogenase
PF575_00350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF575_00365	COG0583	DNA-binding transcription factor activity
PF575_00370	COG0656	L-ascorbic acid biosynthetic process
PF575_00375	COG2814	Major facilitator Superfamily
PF575_00410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF575_00450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF575_00485	COG2963	transposase activity
PF575_00510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF575_00555	COG1113	amino acid transport
PF575_00575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF575_00580	COG1960	acyl-CoA dehydrogenase activity
PF575_00585	COG1024	Enoyl-CoA hydratase
PF575_00590	COG1024	Enoyl-CoA hydratase
PF575_00595	COG0477	Major facilitator Superfamily
PF575_00600	COG3916	Acyl-homoserine-lactone synthase
PF575_00610	COG2197	response regulator
PF575_00620	COG1960	acyl-CoA dehydrogenase activity
PF575_00625	COG3321	synthase
PF575_00625	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF575_00625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PF575_00625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF575_00655	COG2963	transposase activity
PF575_00665	COG4372	Transposase
PF575_00685	COG0271	Belongs to the BolA IbaG family
PF575_00695	COG1192	Involved in chromosome partitioning
PF575_00710	COG0586	Pfam SNARE associated Golgi protein
PF575_00715	COG2259	Doxx family
PF575_00720	COG4399	Belongs to the UPF0754 family
PF575_00725	COG0519	Catalyzes the synthesis of GMP from XMP
PF575_00725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF575_00770	COG0281	malic enzyme
PF575_00780	COG2837	iron assimilation
PF575_00785	COG1280	lysine exporter protein (LysE YggA)
PF575_00790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF575_00795	COG1121	(ABC) transporter
PF575_00865	COG0386	Belongs to the glutathione peroxidase family
PF575_00880	COG1309	transcriptional regulator
PF575_00885	COG0697	spore germination
PF575_00895	COG0758	DNA mediated transformation
PF575_00965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF575_00975	COG0655	NAD(P)H dehydrogenase (quinone) activity
PF575_01015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF575_01025	COG0477	Major facilitator Superfamily
PF575_01035	COG1253	flavin adenine dinucleotide binding
PF575_01040	COG3012	SEC-C Motif Domain Protein
PF575_01045	COG2860	membrane
PF575_01050	COG0477	Major facilitator Superfamily
PF575_01060	COG0318	PFAM AMP-dependent synthetase and ligase
PF575_01075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PF575_01095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF575_01100	COG0235	Class ii aldolase
PF575_01105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF575_01135	COG2963	transposase activity
PF575_01145	COG4372	Transposase
PF575_01155	COG1309	transcriptional regulator
PF575_01175	COG1741	Belongs to the pirin family
PF575_01185	COG2964	Protein conserved in bacteria
PF575_01200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF575_01205	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF575_01210	COG4605	iron ion homeostasis
PF575_01215	COG4604	ABC transporter, ATP-binding protein
PF575_01220	COG4607	ABC-type enterochelin transport system periplasmic component
PF575_01225	COG4774	siderophore transport
PF575_01260	COG2217	Heavy metal translocating P-type atpase
PF575_01265	COG2205	protein histidine kinase activity
PF575_01280	COG2132	Multicopper oxidase
PF575_01370	COG0347	Belongs to the P(II) protein family
PF575_01375	COG0004	ammonium transporteR
PF575_01385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF575_01385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF575_01425	COG0795	lipopolysaccharide-transporting ATPase activity
PF575_01430	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PF575_01435	COG0793	Belongs to the peptidase S41A family
PF575_01450	COG2197	response regulator
PF575_01460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PF575_01470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF575_01475	COG4974	Belongs to the 'phage' integrase family
PF575_01500	COG0772	Belongs to the SEDS family
PF575_01505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF575_01510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF575_01515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF575_01540	COG0697	spore germination
PF575_01545	COG1538	Outer membrane efflux protein
PF575_01565	COG3275	phosphorelay sensor kinase activity
PF575_01575	COG0181	hydroxymethylbilane synthase activity
PF575_01620	COG1716	ATPase activity
PF575_01625	COG0546	phosphoglycolate phosphatase activity
PF575_01725	COG2056	Na+-H+ antiporter family
PF575_01740	COG0326	Molecular chaperone. Has ATPase activity
PF575_01755	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF575_01765	COG0789	Transcriptional regulator
PF575_01815	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PF575_01820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF575_01820	COG2169	Transcriptional regulator
PF575_01850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PF575_01860	COG0497	DNA recombination
PF575_01875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF575_01885	COG0237	dephospho-CoA kinase activity
PF575_01935	COG0195	Participates in both transcription termination and antitermination
PF575_01950	COG1320	monovalent cation:proton antiporter activity
PF575_01955	COG2212	antiporter activity
PF575_01960	COG1863	multisubunit Na H antiporter MnhE subunit
PF575_01965	COG0651	ATP synthesis coupled electron transport
PF575_01970	COG1006	Multisubunit Na H antiporter MnhC subunit
PF575_01975	COG2111	Na H antiporter
PF575_01975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF575_01990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PF575_01995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF575_02010	COG2226	methyltransferase
PF575_02030	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PF575_02035	COG1074	ATP-dependent DNA helicase activity
PF575_02040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF575_02045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF575_02060	COG0598	Magnesium transport protein CorA
PF575_02065	COG0789	Transcriptional regulator
PF575_02070	COG0484	heat shock protein binding
PF575_02085	COG0475	glutathione-regulated potassium exporter activity
PF575_02085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF575_02090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF575_02110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF575_02120	COG4535	Mg2 and Co2 transporter CorC
PF575_02125	COG0425	Belongs to the sulfur carrier protein TusA family
PF575_02135	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
PF575_02135	COG0644	oxidoreductase
PF575_02145	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF575_02160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF575_02165	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PF575_02175	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF575_02175	COG0493	'glutamate synthase
PF575_02200	COG2963	transposase activity
PF575_02210	COG4372	Transposase
PF575_02220	COG4372	Transposase
PF575_02230	COG2963	transposase activity
PF575_02240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PF575_02255	COG0534	Mate efflux family protein
PF575_02265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF575_02270	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_02275	COG0583	DNA-binding transcription factor activity
PF575_02290	COG0318	PFAM AMP-dependent synthetase and ligase
PF575_02295	COG1530	ribonuclease E activity
PF575_02305	COG0546	phosphoglycolate phosphatase activity
PF575_02310	COG2378	regulation of single-species biofilm formation
PF575_02315	COG0625	glutathione transferase activity
PF575_02325	COG0583	DNA-binding transcription factor activity
PF575_02390	COG0473	3-isopropylmalate dehydrogenase activity
PF575_02445	COG1301	dicarboxylic acid transport
PF575_02455	COG1560	Kdo2-lipid A biosynthetic process
PF575_02460	COG1280	lysine exporter protein (LysE YggA)
PF575_02465	COG0488	(ABC) transporter
PF575_02470	COG2900	Belongs to the SlyX family
PF575_02480	COG1733	regulation of RNA biosynthetic process
PF575_02505	COG0210	DNA helicase
PF575_02510	COG0724	RNA recognition motif
PF575_02530	COG4651	solute:proton antiporter activity
PF575_02530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF575_02555	COG0788	formyltetrahydrofolate deformylase activity
PF575_02655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF575_02655	COG2813	Specifically methylates the guanine in position
PF575_02665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF575_02675	COG4774	siderophore transport
PF575_02685	COG0740	serine-type endopeptidase activity
PF575_02705	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
PF575_02705	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
PF575_02710	COG0280	phosphate acetyltransferase
PF575_02710	COG0857	belongs to the CobB CobQ family
PF575_02715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PF575_02725	COG0800	Aldolase
PF575_02735	COG3265	gluconokinase activity
PF575_02740	COG1012	belongs to the aldehyde dehydrogenase family
PF575_02750	COG2267	carboxylic ester hydrolase activity
PF575_02765	COG0793	Belongs to the peptidase S41A family
PF575_02800	COG1426	Protein conserved in bacteria
PF575_02840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PF575_02850	COG1162	GTPase activity
PF575_02855	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PF575_02870	COG1538	Outer membrane efflux protein
PF575_02875	COG0577	efflux transmembrane transporter activity
PF575_02875	COG1136	(ABC) transporter
PF575_02880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF575_02905	COG0028	Belongs to the TPP enzyme family
PF575_02910	COG0440	acetolactate synthase activity
PF575_02940	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PF575_02955	COG0084	hydrolase, TatD family'
PF575_02965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PF575_02975	COG0583	DNA-binding transcription factor activity
PF575_02985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF575_02990	COG2814	Major facilitator Superfamily
PF575_03000	COG0697	spore germination
PF575_03030	COG3622	Belongs to the hyi family
PF575_03035	COG2084	Dehydrogenase
PF575_03040	COG1024	Enoyl-CoA hydratase
PF575_03045	COG0784	Response regulator, receiver
PF575_03045	COG2205	protein histidine kinase activity
PF575_03045	COG5002	protein histidine kinase activity
PF575_03065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF575_03075	COG3956	TIGRFAM MazG family protein
PF575_03080	COG1555	photosystem II stabilization
PF575_03085	COG0617	tRNA 3'-terminal CCA addition
PF575_03090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PF575_03110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF575_03115	COG3028	Belongs to the UPF0307 family
PF575_03120	COG0318	PFAM AMP-dependent synthetase and ligase
PF575_03135	COG0625	glutathione transferase activity
PF575_03140	COG1238	metal cluster binding
PF575_03185	COG0072	phenylalanine-tRNA ligase activity
PF575_03215	COG0248	Ppx GppA phosphatase
PF575_03225	COG0037	tRNA processing
PF575_03265	COG1764	response to oxidative stress
PF575_03270	COG1846	Transcriptional regulator
PF575_03280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF575_03340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF575_03345	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PF575_03350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PF575_03360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF575_03390	COG2963	transposase activity
PF575_03400	COG4372	Transposase
PF575_03430	COG1214	PFAM Peptidase M22, glycoprotease
PF575_03455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PF575_03460	COG0561	phosphatase activity
PF575_03470	COG2132	Multicopper oxidase
PF575_03490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF575_03495	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PF575_03500	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PF575_03530	COG1063	alcohol dehydrogenase
PF575_03535	COG0583	DNA-binding transcription factor activity
PF575_03540	COG1960	acyl-CoA dehydrogenase activity
PF575_03545	COG2814	Major facilitator Superfamily
PF575_03550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PF575_03555	COG1309	transcriptional regulator
PF575_03570	COG1053	succinate dehydrogenase
PF575_03575	COG0583	DNA-binding transcription factor activity
PF575_03590	COG0583	DNA-binding transcription factor activity
PF575_03600	COG0583	DNA-binding transcription factor activity
PF575_03615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF575_03665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF575_03685	COG0745	RESPONSE REGULATOR receiver
PF575_03700	COG3706	GGDEF domain
PF575_03725	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PF575_03755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF575_03760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PF575_03785	COG0583	DNA-binding transcription factor activity
PF575_03805	COG0668	transmembrane transport
PF575_03815	COG2081	HI0933 family
PF575_03820	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PF575_03850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF575_03850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF575_03860	COG0489	protein tyrosine kinase activity
PF575_03910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF575_03920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PF575_03935	COG0730	response to heat
PF575_03945	COG1196	nuclear chromosome segregation
PF575_03965	COG2223	nitrite transmembrane transporter activity
PF575_03970	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
PF575_03975	COG1877	trehalose-phosphatase activity
PF575_03980	COG0596	Alpha beta hydrolase
PF575_03980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF575_03980	COG2226	methyltransferase
PF575_03995	COG4106	trans-aconitate 2-methyltransferase activity
PF575_04010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PF575_04015	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PF575_04020	COG0009	L-threonylcarbamoyladenylate synthase
PF575_04025	COG3101	peptidyl-lysine hydroxylation
PF575_04030	COG1399	metal-binding, possibly nucleic acid-binding protein
PF575_04055	COG1652	LysM domain
PF575_04060	COG0352	thiamine-phosphate diphosphorylase activity
PF575_04060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF575_04060	COG0351	phosphomethylpyrimidine kinase
PF575_04070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PF575_04100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF575_04130	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PF575_04145	COG0358	DNA primase activity
PF575_04155	COG0564	pseudouridine synthase activity
PF575_04180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF575_04200	COG0583	DNA-binding transcription factor activity
PF575_04205	COG0473	3-isopropylmalate dehydrogenase activity
PF575_04215	COG0657	acetylesterase activity
PF575_04225	COG1012	belongs to the aldehyde dehydrogenase family
PF575_04245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PF575_04245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF575_04260	COG1981	membrane
PF575_04305	COG0456	acetyltransferase
PF575_04315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PF575_04320	COG0492	ferredoxin-NADP+ reductase activity
PF575_04325	COG1674	ftsk spoiiie
PF575_04325	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PF575_04330	COG1280	lysine exporter protein (LysE YggA)
PF575_04345	COG2894	cell division
PF575_04360	COG0204	Acyl-transferase
PF575_04365	COG2885	chlorophyll binding
PF575_04370	COG0210	DNA helicase
PF575_04380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF575_04395	COG0121	glutamine amidotransferase
PF575_04415	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PF575_04420	COG0735	belongs to the Fur family
PF575_04445	COG0420	3'-5' exonuclease activity
PF575_04465	COG1090	epimerase
PF575_04480	COG2050	protein possibly involved in aromatic compounds catabolism
PF575_04490	COG2814	Major facilitator Superfamily
PF575_04495	COG0405	Gamma-glutamyltransferase
PF575_04505	COG0582	viral genome integration into host DNA
PF575_04550	COG0629	single-stranded DNA binding
PF575_04590	COG4372	Transposase
PF575_04600	COG2963	transposase activity
PF575_04605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PF575_04620	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PF575_04630	COG4372	Transposase
PF575_04645	COG2963	transposase activity
PF575_04655	COG4372	Transposase
PF575_04690	COG0477	Major facilitator Superfamily
PF575_04750	COG0531	amino acid
PF575_04755	COG2040	homocysteine
PF575_04770	COG2963	transposase activity
PF575_04780	COG4372	Transposase
PF575_04795	COG1309	transcriptional regulator
PF575_04800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF575_04805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF575_04815	COG1607	acyl-coa hydrolase
PF575_04825	COG0523	cobalamin synthesis protein
PF575_04835	COG4681	YaeQ
PF575_04845	COG1649	PFAM Uncharacterised BCR, COG1649
PF575_04845	COG0726	polysaccharide deacetylase
PF575_04850	COG1215	transferase activity, transferring glycosyl groups
PF575_04860	COG1024	Enoyl-CoA hydratase
PF575_04875	COG1414	Transcriptional regulator
PF575_04895	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_04910	COG2271	Major facilitator Superfamily
PF575_04920	COG2267	carboxylic ester hydrolase activity
PF575_04925	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_04940	COG0028	Belongs to the TPP enzyme family
PF575_04950	COG0477	Major facilitator Superfamily
PF575_04955	COG0242	peptide deformylase activity
PF575_04960	COG2066	Belongs to the glutaminase family
PF575_04965	COG2207	Transcriptional regulator
PF575_04970	COG2223	nitrite transmembrane transporter activity
PF575_04985	COG0583	DNA-binding transcription factor activity
PF575_04990	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_04995	COG2271	Major facilitator Superfamily
PF575_05000	COG3959	Transketolase, thiamine diphosphate binding domain
PF575_05005	COG3958	Transketolase
PF575_05015	COG0306	phosphate transporter
PF575_05035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PF575_05085	COG4181	ATPase activity
PF575_05090	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PF575_05120	COG0583	DNA-binding transcription factor activity
PF575_05130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF575_05135	COG1773	rubredoxin
PF575_05185	COG2851	Citrate transporter
PF575_05190	COG1253	flavin adenine dinucleotide binding
PF575_05230	COG0804	urea catabolic process
PF575_05240	COG0830	nickel cation binding
PF575_05255	COG0742	ribosomal rna small subunit methyltransferase
PF575_05260	COG0768	penicillin binding
PF575_05285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PF575_05290	COG2878	Part of a membrane complex involved in electron transport
PF575_05295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF575_05305	COG3384	dioxygenase
PF575_05330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PF575_05640	COG4372	Transposase
PF575_05650	COG2963	transposase activity
PF575_05720	COG0582	viral genome integration into host DNA
PF575_05735	COG0174	glutamine synthetase
PF575_05745	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PF575_05780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF575_05785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PF575_05790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF575_05810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF575_05815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PF575_05820	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PF575_05835	COG1960	acyl-CoA dehydrogenase activity
PF575_05840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF575_05845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF575_05855	COG2223	nitrite transmembrane transporter activity
PF575_05865	COG0024	Methionine aminopeptidase
PF575_05870	COG0052	Belongs to the universal ribosomal protein uS2 family
PF575_05885	COG2207	Transcriptional regulator
PF575_05910	COG2951	lytic endotransglycosylase activity
PF575_05915	COG0772	Belongs to the SEDS family
PF575_05930	COG0842	Transport permease protein
PF575_05935	COG1131	(ABC) transporter
PF575_05980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF575_05995	COG4215	(ABC) transporter
PF575_06000	COG4160	amino acid transport
PF575_06005	COG4598	ABC transporter
PF575_06015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF575_06020	COG0826	peptidase U32
PF575_06025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF575_06030	COG0384	phenazine biosynthesis protein PhzF
PF575_06040	COG1720	tRNA m6t6A37 methyltransferase activity
PF575_06075	COG0642	Histidine kinase
PF575_06085	COG0494	nUDIX hydrolase
PF575_06095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF575_06100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF575_06105	COG3139	Protein of unknown function (DUF1315)
PF575_06110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PF575_06115	COG1301	dicarboxylic acid transport
PF575_06120	COG1960	acyl-CoA dehydrogenase activity
PF575_06125	COG2819	hydrolase of the alpha beta superfamily
PF575_06135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PF575_06145	COG2195	Cleaves the N-terminal amino acid of tripeptides
PF575_06150	COG1234	tRNA 3'-trailer cleavage
PF575_06180	COG2363	Small membrane protein
PF575_06205	COG0513	Belongs to the DEAD box helicase family
PF575_06215	COG0778	Nitroreductase
PF575_06245	COG1286	toxin biosynthetic process
PF575_06270	COG4783	chaperone-mediated protein folding
PF575_06275	COG1610	YqeY-like protein
PF575_06305	COG0515	serine threonine protein kinase
PF575_06305	COG2815	serine threonine protein kinase
PF575_06330	COG2831	hemolysin activation secretion protein
PF575_06335	COG3210	domain, Protein
PF575_06335	COG3210	domain, Protein
PF575_06405	COG0477	Major facilitator Superfamily
PF575_06410	COG1051	belongs to the nudix hydrolase family
PF575_06440	COG2995	paraquat-inducible protein a
PF575_06445	COG3008	intermembrane lipid transfer
PF575_06445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PF575_06455	COG1794	racemase activity, acting on amino acids and derivatives
PF575_06490	COG1301	dicarboxylic acid transport
PF575_06500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF575_06505	COG2011	ABC-type metal ion transport system permease component
PF575_06510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF575_06515	COG1464	Belongs to the NlpA lipoprotein family
PF575_06520	COG0151	Belongs to the GarS family
PF575_06525	COG0138	bifunctional purine biosynthesis protein purh
PF575_06530	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PF575_06560	COG2308	Evidence 4 Homologs of previously reported genes of
PF575_06570	COG1305	Transglutaminase-like
PF575_06580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF575_06585	COG0305	Participates in initiation and elongation during chromosome replication
PF575_06610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PF575_06620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF575_06625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF575_06650	COG1649	PFAM Uncharacterised BCR, COG1649
PF575_06650	COG0726	polysaccharide deacetylase
PF575_06655	COG1215	transferase activity, transferring glycosyl groups
PF575_06660	COG3658	cytochrome
PF575_06670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF575_06685	COG0583	DNA-binding transcription factor activity
PF575_06715	COG1960	acyl-CoA dehydrogenase activity
PF575_06720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF575_06725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF575_06740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PF575_06750	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PF575_06755	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
PF575_06765	COG2205	protein histidine kinase activity
PF575_06770	COG0745	RESPONSE REGULATOR receiver
PF575_06775	COG0174	glutamine synthetase
PF575_06795	COG0729	surface antigen
PF575_06820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF575_06825	COG2814	Major facilitator Superfamily
PF575_06840	COG0583	DNA-binding transcription factor activity
PF575_06855	COG1187	pseudouridine synthase activity
PF575_06875	COG0802	atpase or kinase
PF575_06880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PF575_06890	COG1923	regulation of RNA biosynthetic process
PF575_06895	COG0697	spore germination
PF575_06910	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF575_06920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF575_06925	COG0519	Catalyzes the synthesis of GMP from XMP
PF575_06925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF575_06930	COG4302	ethanolamine ammonia-lyase activity
PF575_06935	COG4303	Ethanolamine ammonia lyase large subunit
PF575_06940	COG0531	amino acid
PF575_06960	COG1454	alcohol dehydrogenase
PF575_06965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF575_06975	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
PF575_06995	COG0308	aminopeptidase N
PF575_07035	COG1605	Chorismate mutase
PF575_07050	COG1309	transcriptional regulator
PF575_07060	COG0668	transmembrane transport
PF575_07090	COG4773	Receptor
PF575_07110	COG0488	(ABC) transporter
PF575_07115	COG0589	response to stress
PF575_07140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PF575_07150	COG3135	benzoate transporter
PF575_07155	COG1522	sequence-specific DNA binding
PF575_07165	COG2963	transposase activity
PF575_07175	COG4372	Transposase
PF575_07185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PF575_07190	COG0583	DNA-binding transcription factor activity
PF575_07200	COG0183	Belongs to the thiolase family
PF575_07210	COG2030	dehydratase
PF575_07215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF575_07230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PF575_07245	COG0824	Thioesterase
PF575_07250	COG1454	alcohol dehydrogenase
PF575_07260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF575_07280	COG0069	glutamate synthase activity
PF575_07300	COG2814	Major facilitator Superfamily
PF575_07310	COG0439	Biotin carboxylase
PF575_07315	COG0511	ligase activity, forming carbon-carbon bonds
PF575_07330	COG1116	anion transmembrane transporter activity
PF575_07330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF575_07335	COG0745	RESPONSE REGULATOR receiver
PF575_07345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF575_07345	COG2146	nitrite reductase [NAD(P)H] activity
PF575_07350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF575_07355	COG0243	molybdopterin cofactor binding
PF575_07365	COG0243	molybdopterin cofactor binding
PF575_07370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PF575_07385	COG0315	cyclic pyranopterin monophosphate synthase activity
PF575_07385	COG0521	Mo-molybdopterin cofactor biosynthetic process
PF575_07390	COG0303	'Molybdopterin
PF575_07400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF575_07405	COG0697	spore germination
PF575_07425	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PF575_07430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF575_07500	COG2204	response regulator
PF575_07505	COG3852	Histidine kinase
PF575_07530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PF575_07535	COG0575	Belongs to the CDS family
PF575_07570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF575_07585	COG2137	regulation of response to DNA damage stimulus
PF575_07595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PF575_07600	COG1011	Hydrolase
PF575_07625	COG1522	sequence-specific DNA binding
PF575_07635	COG1113	amino acid transport
PF575_07660	COG4372	Transposase
PF575_07670	COG2963	transposase activity
PF575_07675	COG0659	secondary active sulfate transmembrane transporter activity
PF575_07680	COG2135	peptidase activity
PF575_07695	COG2963	transposase activity
PF575_07705	COG4372	Transposase
PF575_07715	COG3300	MHYT domain
PF575_07715	COG5001	Diguanylate cyclase
PF575_07730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF575_07730	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PF575_07730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF575_07735	COG1105	Belongs to the carbohydrate kinase PfkB family
PF575_07740	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF575_07740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PF575_07770	COG0024	Methionine aminopeptidase
PF575_07775	COG0583	DNA-binding transcription factor activity
PF575_07785	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PF575_07790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF575_07795	COG0517	IMP dehydrogenase activity
PF575_07795	COG0516	GMP reductase activity
PF575_07820	COG0552	protein localization to endoplasmic reticulum
PF575_07830	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
PF575_07840	COG4890	Cyd operon protein YbgT
PF575_07845	COG1294	oxidase, subunit
PF575_07860	COG4372	Transposase
PF575_07870	COG2963	transposase activity
PF575_07875	COG1585	Membrane protein implicated in regulation of membrane protease activity
PF575_07885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF575_07890	COG4774	siderophore transport
PF575_07905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PF575_07910	COG0569	domain protein
PF575_07915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF575_07945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PF575_07950	COG0542	response to heat
PF575_07975	COG1902	pentaerythritol trinitrate reductase activity
PF575_07975	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF575_08020	COG2323	membrane
PF575_08025	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PF575_08035	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF575_08040	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF575_08045	COG0183	Belongs to the thiolase family
PF575_08050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PF575_08055	COG0596	Alpha beta hydrolase
PF575_08060	COG2271	Major facilitator Superfamily
PF575_08065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF575_08070	COG3485	protocatechuate 3,4-dioxygenase
PF575_08075	COG3485	protocatechuate 3,4-dioxygenase
PF575_08080	COG0710	3-dehydroquinate dehydratase activity
PF575_08085	COG3420	alginic acid biosynthetic process
PF575_08090	COG3659	wide pore channel activity
PF575_08095	COG4993	Dehydrogenase
PF575_08105	COG2391	methyltransferase activity
PF575_08120	COG1414	Transcriptional regulator
PF575_08125	COG0583	DNA-binding transcription factor activity
PF575_08130	COG1960	acyl-CoA dehydrogenase activity
PF575_08155	COG2814	Major facilitator Superfamily
PF575_08165	COG0154	amidase activity
PF575_08185	COG4638	Rieske (2fe-2S)
PF575_08195	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_08205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF575_08215	COG3733	amine oxidase
PF575_08225	COG1012	belongs to the aldehyde dehydrogenase family
PF575_08235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF575_08240	COG0183	Belongs to the thiolase family
PF575_08245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF575_08250	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF575_08260	COG4829	muconolactone delta-isomerase
PF575_08265	COG4948	Mandelate Racemase Muconate Lactonizing
PF575_08270	COG0583	DNA-binding transcription factor activity
PF575_08280	COG2186	Transcriptional regulator
PF575_08300	COG1012	belongs to the aldehyde dehydrogenase family
PF575_08315	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF575_08315	COG1902	pentaerythritol trinitrate reductase activity
PF575_08355	COG1309	transcriptional regulator
PF575_08365	COG1335	isochorismatase
PF575_08370	COG0583	DNA-binding transcription factor activity
PF575_08380	COG0475	glutathione-regulated potassium exporter activity
PF575_08380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF575_08390	COG1473	amidohydrolase
PF575_08405	COG4191	Histidine kinase
PF575_08440	COG2188	Transcriptional regulator
PF575_08455	COG0583	DNA-binding transcription factor activity
PF575_08480	COG1566	PFAM secretion protein HlyD family protein
PF575_08495	COG1012	belongs to the aldehyde dehydrogenase family
PF575_08500	COG0129	dihydroxy-acid dehydratase activity
PF575_08510	COG0583	DNA-binding transcription factor activity
PF575_08515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF575_08525	COG2084	Dehydrogenase
PF575_08530	COG2207	Transcriptional regulator
PF575_08545	COG1064	alcohol dehydrogenase
PF575_08555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF575_08560	COG1120	ATPase activity
PF575_08580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF575_08635	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PF575_08670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF575_08705	COG0477	Major facilitator Superfamily
PF575_08715	COG2963	transposase activity
PF575_08725	COG4372	Transposase
PF575_08740	COG1414	Transcriptional regulator
PF575_08795	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PF575_08805	COG0753	catalase activity
PF575_08825	COG4372	Transposase
PF575_08835	COG2963	transposase activity
PF575_08905	COG3433	isochorismatase activity
PF575_08905	COG1535	isochorismatase
PF575_08910	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_08915	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PF575_08920	COG4149	molybdate abc transporter
PF575_08925	COG0725	ABC transporter, periplasmic molybdate-binding protein
PF575_08935	COG4638	Rieske (2fe-2S)
PF575_08940	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
PF575_08945	COG0543	2 iron, 2 sulfur cluster binding
PF575_08945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF575_08960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF575_08970	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_08985	COG2207	Transcriptional regulator
PF575_08990	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_08995	COG2610	gluconate transmembrane transporter activity
PF575_09005	COG1309	transcriptional regulator
PF575_09025	COG0583	DNA-binding transcription factor activity
PF575_09040	COG2031	fatty acid transporter
PF575_09045	COG0183	Belongs to the thiolase family
PF575_09050	COG0583	DNA-binding transcription factor activity
PF575_09055	COG0583	DNA-binding transcription factor activity
PF575_09070	COG1027	Aspartate ammonia-lyase
PF575_09080	COG0477	Major facilitator Superfamily
PF575_09105	COG4521	taurine ABC transporter
PF575_09120	COG2188	Transcriptional regulator
PF575_09130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF575_09135	COG1733	regulation of RNA biosynthetic process
PF575_09140	COG2207	Transcriptional regulator
PF575_09140	COG3708	Transcriptional regulator
PF575_09155	COG0730	response to heat
PF575_09170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF575_09170	COG3453	Protein conserved in bacteria
PF575_09180	COG3781	membrane
PF575_09185	COG1063	alcohol dehydrogenase
PF575_09195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF575_09200	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF575_09205	COG0022	dehydrogenase e1 component
PF575_09210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF575_09215	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF575_09230	COG3706	GGDEF domain
PF575_09235	COG4372	Transposase
PF575_09245	COG2963	transposase activity
PF575_09260	COG0133	tryptophan synthase activity
PF575_09270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF575_09305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PF575_09330	COG2226	methyltransferase
PF575_09370	COG4372	Transposase
PF575_09380	COG2963	transposase activity
PF575_09400	COG0842	Transport permease protein
PF575_09405	COG0842	Transport permease protein
PF575_09410	COG1131	(ABC) transporter
PF575_09425	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF575_09430	COG4773	Receptor
PF575_09450	COG0730	response to heat
PF575_09455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PF575_09475	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PF575_09490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF575_09520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PF575_09530	COG4264	IucA IucC family
PF575_09535	COG4264	IucA IucC family
PF575_09555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PF575_09570	COG1960	acyl-CoA dehydrogenase activity
PF575_09575	COG1960	acyl-CoA dehydrogenase activity
PF575_09580	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF575_09585	COG2207	Transcriptional regulator
PF575_09590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF575_09595	COG0776	regulation of translation
PF575_09620	COG0822	iron-sulfur transferase activity
PF575_09625	COG0316	Belongs to the HesB IscA family
PF575_09655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PF575_09675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PF575_09680	COG0702	epimerase
PF575_09715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF575_09725	COG0339	signal peptide processing
PF575_09775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PF575_09780	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PF575_09810	COG0776	regulation of translation
PF575_09875	COG0084	hydrolase, TatD family'
PF575_09895	COG1663	tetraacyldisaccharide 4'-kinase activity
PF575_09900	COG1132	(ABC) transporter
PF575_09910	COG0811	peptide transport
PF575_09915	COG1475	DNA binding
PF575_09920	COG1192	Involved in chromosome partitioning
PF575_09930	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PF575_09945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF575_09950	COG0191	fructose-bisphosphate aldolase activity
PF575_09970	COG0424	maF-like protein
PF575_09975	COG2850	peptidyl-arginine hydroxylation
PF575_09985	COG0640	Transcriptional regulator
PF575_09995	COG3619	membrane
PF575_10000	COG3122	Protein conserved in bacteria
PF575_10005	COG1132	(ABC) transporter
PF575_10025	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PF575_10030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF575_10040	COG0506	proline dehydrogenase activity
PF575_10040	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PF575_10040	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PF575_10045	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PF575_10060	COG3698	Phosphodiester glycosidase
PF575_10070	COG2353	YceI-like domain
PF575_10080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PF575_10110	COG4372	Transposase
PF575_10120	COG2963	transposase activity
PF575_10150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PF575_10150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PF575_10175	COG3539	Fimbrial protein
PF575_10180	COG3121	Chaperone
PF575_10210	COG2963	transposase activity
PF575_10220	COG4372	Transposase
PF575_10235	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF575_10245	COG0583	DNA-binding transcription factor activity
PF575_10265	COG1309	transcriptional regulator
PF575_10280	COG1522	sequence-specific DNA binding
PF575_10290	COG1126	abc transporter atp-binding protein
PF575_10295	COG0765	amino acid transport
PF575_10300	COG0765	amino acid transport
PF575_10330	COG1464	Belongs to the NlpA lipoprotein family
PF575_10340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF575_10345	COG2011	ABC-type metal ion transport system permease component
PF575_10350	COG0012	GTP binding
PF575_10375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF575_10410	COG4372	Transposase
PF575_10420	COG2963	transposase activity
PF575_10435	COG0386	Belongs to the glutathione peroxidase family
PF575_10445	COG0436	Aminotransferase
PF575_10490	COG3634	alkyl hydroperoxide reductase activity
PF575_10505	COG0583	DNA-binding transcription factor activity
PF575_10510	COG0798	PFAM Bile acid sodium symporter
PF575_10515	COG0640	Transcriptional regulator
PF575_10530	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PF575_10540	COG0583	DNA-binding transcription factor activity
PF575_10550	COG1953	Uracil, thiamine, allantoin
PF575_10560	COG2175	clavaminate synthase activity
PF575_10565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF575_10570	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PF575_10575	COG4521	taurine ABC transporter
PF575_10595	COG0477	Major facilitator Superfamily
PF575_10615	COG1271	oxidase subunit
PF575_10620	COG1294	oxidase, subunit
PF575_10630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF575_10650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF575_10670	COG3052	prosthetic group binding
PF575_10675	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
PF575_10685	COG0583	DNA-binding transcription factor activity
PF575_10695	COG2814	Major facilitator Superfamily
PF575_10715	COG1346	cytolysis
PF575_10725	COG0583	DNA-binding transcription factor activity
PF575_10730	COG0625	glutathione transferase activity
PF575_10735	COG0625	glutathione transferase activity
PF575_10740	COG0583	DNA-binding transcription factor activity
PF575_10755	COG1045	serine acetyltransferase
PF575_10760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF575_10765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF575_10770	COG1280	lysine exporter protein (LysE YggA)
PF575_10785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF575_10790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF575_10795	COG1126	abc transporter atp-binding protein
PF575_10800	COG0765	amino acid transport
PF575_10805	COG0765	amino acid transport
PF575_10825	COG0784	Response regulator, receiver
PF575_10825	COG2205	protein histidine kinase activity
PF575_10845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PF575_10865	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_10915	COG0583	DNA-binding transcription factor activity
PF575_10935	COG0318	PFAM AMP-dependent synthetase and ligase
PF575_10940	COG1309	transcriptional regulator
PF575_10945	COG1960	acyl-CoA dehydrogenase activity
PF575_10950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF575_10955	COG1024	Enoyl-CoA hydratase
PF575_10960	COG4770	biotin carboxylase activity
PF575_10970	COG0583	DNA-binding transcription factor activity
PF575_10985	COG1960	acyl-CoA dehydrogenase activity
PF575_10995	COG2814	Major facilitator Superfamily
PF575_11005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF575_11010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF575_11015	COG2814	Major facilitator Superfamily
PF575_11020	COG1960	acyl-CoA dehydrogenase activity
PF575_11025	COG1024	Enoyl-CoA hydratase
PF575_11030	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_11035	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF575_11040	COG0183	Belongs to the thiolase family
PF575_11050	COG2814	Major facilitator Superfamily
PF575_11060	COG1024	Enoyl-CoA hydratase
PF575_11070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PF575_11075	COG1960	acyl-CoA dehydrogenase activity
PF575_11080	COG2814	Major facilitator Superfamily
PF575_11085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF575_11090	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PF575_11105	COG3842	ATPase activity
PF575_11110	COG1840	ABC-type Fe3 transport system, periplasmic component
PF575_11120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF575_11125	COG1414	Transcriptional regulator
PF575_11135	COG0583	DNA-binding transcription factor activity
PF575_11140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF575_11145	COG1012	belongs to the aldehyde dehydrogenase family
PF575_11155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF575_11165	COG1012	belongs to the aldehyde dehydrogenase family
PF575_11170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF575_11175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF575_11180	COG2267	carboxylic ester hydrolase activity
PF575_11200	COG3038	cytochrome b561
PF575_11205	COG0753	catalase activity
PF575_11235	COG2050	protein possibly involved in aromatic compounds catabolism
PF575_11245	COG3327	negative regulation of DNA-templated transcription, initiation
PF575_11250	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PF575_11255	COG0183	Belongs to the thiolase family
PF575_11260	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF575_11265	COG1024	Enoyl-CoA hydratase
PF575_11270	COG1024	Enoyl-CoA hydratase
PF575_11275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF575_11280	COG2151	metal-sulfur cluster biosynthetic enzyme
PF575_11285	COG3396	Phenylacetate-CoA oxygenase
PF575_11290	COG3460	Phenylacetate-CoA oxygenase
PF575_11295	COG3396	Phenylacetate-CoA oxygenase
PF575_11300	COG1012	belongs to the aldehyde dehydrogenase family
PF575_11300	COG2030	dehydratase
PF575_11305	COG1760	l-serine dehydratase
PF575_11310	COG0531	amino acid
PF575_11315	COG1012	belongs to the aldehyde dehydrogenase family
PF575_11340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF575_11360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF575_11370	COG0789	Transcriptional regulator
PF575_11380	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PF575_11395	COG2807	transmembrane transport
PF575_11400	COG0590	tRNA wobble adenosine to inosine editing
PF575_11515	COG1116	anion transmembrane transporter activity
PF575_11520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF575_11530	COG0864	Transcriptional regulator
PF575_11545	COG1733	regulation of RNA biosynthetic process
PF575_11550	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF575_11555	COG0439	Biotin carboxylase
PF575_11570	COG1063	alcohol dehydrogenase
PF575_11595	COG3210	domain, Protein
PF575_11600	COG2831	hemolysin activation secretion protein
PF575_11605	COG0038	chloride channel
PF575_11610	COG4770	biotin carboxylase activity
PF575_11630	COG1914	H( )-stimulated, divalent metal cation uptake system
PF575_11635	COG0583	DNA-binding transcription factor activity
PF575_11675	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF575_11695	COG2814	Major facilitator Superfamily
PF575_11710	COG1560	Kdo2-lipid A biosynthetic process
PF575_11725	COG1522	sequence-specific DNA binding
PF575_11740	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PF575_11750	COG4122	O-methyltransferase activity
PF575_11780	COG4372	Transposase
PF575_11790	COG2963	transposase activity
PF575_11800	COG1538	Outer membrane efflux protein
PF575_11805	COG1137	ATPase activity
PF575_11810	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PF575_11820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PF575_11860	COG2814	Major facilitator Superfamily
PF575_11895	COG1278	Cold shock
PF575_11900	COG1280	lysine exporter protein (LysE YggA)
PF575_11930	COG1570	exodeoxyribonuclease VII activity
PF575_11980	COG0583	DNA-binding transcription factor activity
PF575_11990	COG4638	Rieske (2fe-2S)
PF575_11995	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
PF575_12000	COG0633	Ferredoxin
PF575_12000	COG0543	2 iron, 2 sulfur cluster binding
PF575_12005	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_12010	COG3135	benzoate transporter
PF575_12015	COG2814	Major facilitator Superfamily
PF575_12030	COG1643	Atp-dependent helicase
PF575_12035	COG0450	alkyl hydroperoxide reductase
PF575_12045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PF575_12055	COG3634	alkyl hydroperoxide reductase activity
PF575_12075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PF575_12080	COG0625	glutathione transferase activity
PF575_12090	COG2885	chlorophyll binding
PF575_12125	COG0542	response to heat
PF575_12140	COG1765	OsmC-like protein
PF575_12155	COG0667	Aldo Keto reductase
PF575_12170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PF575_12185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF575_12195	COG0527	aspartate kinase activity
PF575_12205	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PF575_12215	COG3038	cytochrome b561
PF575_12220	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PF575_12225	COG2252	PERMEase
PF575_12235	COG2072	flavoprotein involved in K transport
PF575_12250	COG1741	Belongs to the pirin family
PF575_12255	COG1309	transcriptional regulator
PF575_12265	COG0300	oxidoreductase activity
PF575_12270	COG2072	flavoprotein involved in K transport
PF575_12275	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
PF575_12320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PF575_12335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF575_12350	COG2814	Major facilitator Superfamily
PF575_12355	COG1024	Enoyl-CoA hydratase
PF575_12360	COG1012	belongs to the aldehyde dehydrogenase family
PF575_12370	COG1960	acyl-CoA dehydrogenase activity
PF575_12395	COG2186	Transcriptional regulator
PF575_12400	COG1012	belongs to the aldehyde dehydrogenase family
PF575_12410	COG4948	Mandelate Racemase Muconate Lactonizing
PF575_12415	COG2271	Major facilitator Superfamily
PF575_12420	COG2721	sulfolactate sulfo-lyase activity
PF575_12425	COG0697	spore germination
PF575_12440	COG1113	amino acid transport
PF575_12460	COG1012	belongs to the aldehyde dehydrogenase family
PF575_12480	COG0531	amino acid
PF575_12490	COG1113	amino acid transport
PF575_12535	COG4269	membrane
PF575_12550	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF575_12550	COG1902	pentaerythritol trinitrate reductase activity
PF575_12580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF575_12600	COG4172	Belongs to the ABC transporter superfamily
PF575_12605	COG4239	(ABC) transporter, permease
PF575_12610	COG4174	ABC transporter (Permease)
PF575_12620	COG0741	lytic transglycosylase activity
PF575_12620	COG1388	LysM domain
PF575_12620	COG0741	lytic transglycosylase activity
PF575_12620	COG1388	LysM domain
PF575_12625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF575_12665	COG0583	DNA-binding transcription factor activity
PF575_12670	COG1279	arginine transmembrane transporter activity
PF575_12690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF575_12695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF575_12700	COG0006	proline dipeptidase activity
PF575_12735	COG2194	sulfuric ester hydrolase activity
PF575_12790	COG0739	heme binding
PF575_12790	COG0741	lytic transglycosylase activity
PF575_12790	COG1196	nuclear chromosome segregation
PF575_12965	COG3617	BRO family, N-terminal domain
PF575_13120	COG0512	Glutamine amidotransferase of anthranilate synthase
PF575_13125	COG0308	aminopeptidase N
PF575_13155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PF575_13165	COG0302	gtp cyclohydrolase
PF575_13185	COG4372	Transposase
PF575_13195	COG2963	transposase activity
PF575_13210	COG3739	integral membrane protein
PF575_13230	COG2977	Belongs to the P-Pant transferase superfamily
PF575_13235	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
PF575_13240	COG1132	(ABC) transporter
PF575_13245	COG1132	(ABC) transporter
PF575_13255	COG3433	isochorismatase activity
PF575_13255	COG1535	isochorismatase
PF575_13260	COG1021	2,3-dihydroxybenzoate-AMP ligase
PF575_13265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF575_13275	COG4774	siderophore transport
PF575_13280	COG4607	ABC-type enterochelin transport system periplasmic component
PF575_13285	COG4604	ABC transporter, ATP-binding protein
PF575_13290	COG4605	iron ion homeostasis
PF575_13295	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF575_13300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF575_13315	COG2964	Protein conserved in bacteria
PF575_13325	COG1741	Belongs to the pirin family
PF575_13345	COG1309	transcriptional regulator
PF575_13355	COG4372	Transposase
PF575_13365	COG2963	transposase activity
PF575_13375	COG4948	Mandelate Racemase Muconate Lactonizing
PF575_13380	COG2814	Major facilitator Superfamily
PF575_13415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF575_13415	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PF575_13420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF575_13430	COG1012	belongs to the aldehyde dehydrogenase family
PF575_13445	COG0477	Major facilitator Superfamily
PF575_13450	COG0006	proline dipeptidase activity
PF575_13455	COG1902	pentaerythritol trinitrate reductase activity
PF575_13460	COG0583	DNA-binding transcription factor activity
PF575_13470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF575_13480	COG0596	Alpha beta hydrolase
PF575_13495	COG0583	DNA-binding transcription factor activity
PF575_13500	COG1335	isochorismatase
PF575_13550	COG2879	small protein
PF575_13555	COG1966	Carbon starvation protein
PF575_13575	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PF575_13600	COG1067	ATP-dependent peptidase activity
PF575_13605	COG0583	DNA-binding transcription factor activity
PF575_13630	COG1686	Belongs to the peptidase S11 family
PF575_13635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PF575_13670	COG0616	signal peptide processing
PF575_13675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF575_13685	COG0573	inorganic phosphate transmembrane transporter activity
PF575_13690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PF575_13695	COG1113	amino acid transport
PF575_13700	COG3961	Belongs to the TPP enzyme family
PF575_13705	COG1522	sequence-specific DNA binding
PF575_13715	COG0076	glutamate decarboxylase activity
PF575_13720	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF575_13735	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF575_13745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF575_13780	COG0352	thiamine-phosphate diphosphorylase activity
PF575_13790	COG2963	transposase activity
PF575_13800	COG4372	Transposase
PF575_13825	COG0612	Peptidase, M16
PF575_13835	COG1823	symporter activity
PF575_13840	COG0583	DNA-binding transcription factor activity
PF575_13845	COG0477	Major facilitator Superfamily
PF575_13870	COG1187	pseudouridine synthase activity
PF575_13885	COG1686	Belongs to the peptidase S11 family
PF575_13890	COG1252	NADH dehydrogenase
PF575_13900	COG0415	Belongs to the DNA photolyase family
PF575_13915	COG1215	transferase activity, transferring glycosyl groups
PF575_13945	COG2070	2-Nitropropane dioxygenase
PF575_14000	COG0556	nucleotide-excision repair
PF575_14020	COG0436	Aminotransferase
PF575_14030	COG0443	Heat shock 70 kDa protein
PF575_14060	COG4221	oxidoreductase activity
PF575_14070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PF575_14075	COG1381	Involved in DNA repair and RecF pathway recombination
PF575_14085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PF575_14100	COG0681	Belongs to the peptidase S26 family
PF575_14115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF575_14135	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF575_14140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF575_14145	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PF575_14155	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PF575_14160	COG4208	sulfate ABC transporter
PF575_14165	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PF575_14170	COG0583	DNA-binding transcription factor activity
PF575_14175	COG4625	pathogenesis
PF575_14190	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PF575_14205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PF575_14215	COG1051	belongs to the nudix hydrolase family
PF575_14215	COG1056	cytidyltransferase-related domain
PF575_14220	COG1024	Enoyl-CoA hydratase
PF575_14235	COG2814	Major facilitator Superfamily
PF575_14240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PF575_14240	COG0047	phosphoribosylformylglycinamidine synthase activity
PF575_14260	COG1473	amidohydrolase
PF575_14265	COG0824	Thioesterase
PF575_14285	COG0823	Involved in the tonB-independent uptake of proteins
PF575_14305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF575_14325	COG2963	transposase activity
PF575_14335	COG4372	Transposase
PF575_14355	COG0628	permease
PF575_14365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PF575_14370	COG0596	Alpha beta hydrolase
PF575_14375	COG0616	signal peptide processing
PF575_14375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PF575_14385	COG2333	competence protein COMEC
PF575_14385	COG0658	competence protein
PF575_14390	COG1136	(ABC) transporter
PF575_14395	COG4591	ABC-type transport system involved in lipoprotein release permease component
PF575_14430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF575_14450	COG0463	Glycosyl transferase, family 2
PF575_14480	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PF575_14485	COG1280	lysine exporter protein (LysE YggA)
PF575_14495	COG0019	diaminopimelate decarboxylase activity
PF575_14505	COG1113	amino acid transport
PF575_14520	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PF575_14530	COG3339	Conserved Protein
PF575_14535	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PF575_14540	COG0243	molybdopterin cofactor binding
PF575_14545	COG1929	Belongs to the glycerate kinase type-1 family
PF575_14560	COG0778	Nitroreductase
PF575_14580	COG3811	Belongs to the UPF0386 family
PF575_14605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PF575_14625	COG0741	lytic transglycosylase activity
PF575_14645	COG0584	glycerophosphoryl diester phosphodiesterase
PF575_14650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF575_14675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF575_14680	COG1597	lipid kinase activity
PF575_14695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PF575_14700	COG0477	Major facilitator Superfamily
PF575_14750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PF575_14755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF575_14780	COG0505	Belongs to the CarA family
PF575_14800	COG0589	response to stress
PF575_14815	COG2843	Capsule synthesis protein
PF575_14835	COG2321	neutral zinc metallopeptidase
PF575_14840	COG2354	Protein conserved in bacteria
PF575_14860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF575_14885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PF575_14890	COG1053	succinate dehydrogenase
PF575_14895	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PF575_14900	COG2009	succinate dehydrogenase
PF575_14940	COG2921	Belongs to the UPF0250 family
PF575_14945	COG0321	lipoyl(octanoyl) transferase activity
PF575_14960	COG0531	amino acid
PF575_14970	COG1733	regulation of RNA biosynthetic process
PF575_14975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PF575_14980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF575_14980	COG1648	precorrin-2 dehydrogenase activity
PF575_14995	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PF575_15025	COG0671	phosphoesterase, PA-phosphatase related
PF575_15030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF575_15040	COG1538	Outer membrane efflux protein
PF575_15045	COG0393	Putative heavy-metal-binding
PF575_15050	COG0393	Putative heavy-metal-binding
PF575_15060	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_15070	COG0525	valine-tRNA ligase activity
PF575_15075	COG2226	methyltransferase
PF575_15090	COG0583	DNA-binding transcription factor activity
PF575_15095	COG0004	ammonium transporteR
PF575_15105	COG0642	Histidine kinase
PF575_15110	COG0745	RESPONSE REGULATOR receiver
PF575_15120	COG2963	transposase activity
PF575_15130	COG4372	Transposase
PF575_15145	COG4372	Transposase
PF575_15155	COG2963	transposase activity
PF575_15170	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF575_15185	COG2315	Protein conserved in bacteria
PF575_15190	COG0142	geranyltranstransferase activity
PF575_15195	COG2828	Protein conserved in bacteria
PF575_15200	COG1113	amino acid transport
PF575_15245	COG2207	Transcriptional regulator
PF575_15270	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF575_15280	COG0560	Phosphoserine phosphatase
PF575_15290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF575_15300	COG1530	ribonuclease E activity
PF575_15305	COG0424	maF-like protein
PF575_15310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PF575_15315	COG1792	Involved in formation and maintenance of cell shape
PF575_15320	COG1077	Cell shape determining protein MreB Mrl
PF575_15325	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF575_15335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF575_15360	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
PF575_15365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF575_15370	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF575_15375	COG1115	amino acid carrier protein
PF575_15395	COG2814	Major facilitator Superfamily
PF575_15400	COG1289	transmembrane transporter activity
PF575_15410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF575_15450	COG1376	ErfK ybiS ycfS ynhG family protein
PF575_15455	COG2832	Protein of unknown function (DUF454)
PF575_15465	COG5510	response to toxic substance
PF575_15485	COG0840	transmembrane signaling receptor activity
PF575_15525	COG3422	double-strand break repair
PF575_15530	COG2824	Alkylphosphonate utilization operon protein PhnA
PF575_15535	COG3189	MarR family transcriptional regulator
PF575_15545	COG0354	folic acid binding
PF575_15550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF575_15560	COG0679	Auxin Efflux Carrier
PF575_15565	COG1902	pentaerythritol trinitrate reductase activity
PF575_15570	COG4772	TonB-dependent receptor
PF575_15575	COG2094	Belongs to the DNA glycosylase MPG family
PF575_15600	COG1217	gtp-binding protein TYPA
PF575_15605	COG2233	PERMEase
PF575_15615	COG0833	amino acid
PF575_15620	COG1690	Belongs to the RtcB family
PF575_15630	COG2885	chlorophyll binding
PF575_15630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PF575_15640	COG0183	Belongs to the thiolase family
PF575_15660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF575_15680	COG2207	Transcriptional regulator
PF575_15685	COG0183	Belongs to the thiolase family
PF575_15715	COG1272	protein, Hemolysin III
PF575_15720	COG0477	Major facilitator Superfamily
PF575_15735	COG0450	alkyl hydroperoxide reductase
PF575_15755	COG0285	dihydrofolate synthase activity
PF575_15805	COG2096	Adenosyltransferase
PF575_15825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PF575_15830	COG0745	RESPONSE REGULATOR receiver
PF575_15835	COG2205	protein histidine kinase activity
PF575_15845	COG1960	acyl-CoA dehydrogenase activity
PF575_15850	COG1960	acyl-CoA dehydrogenase activity
PF575_15915	COG0438	transferase activity, transferring glycosyl groups
PF575_15920	COG0463	Glycosyl transferase, family 2
PF575_15925	COG0726	polysaccharide deacetylase
PF575_15945	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PF575_15950	COG2205	protein histidine kinase activity
PF575_15980	COG1862	Preprotein translocase
PF575_15990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF575_15995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PF575_16005	COG3781	membrane
PF575_16010	COG0613	PHP domain protein
PF575_16020	COG2350	Protein conserved in bacteria
PF575_16050	COG1607	acyl-coa hydrolase
PF575_16110	COG2199	diguanylate cyclase activity
PF575_16120	COG1408	metallophosphoesterase
PF575_16125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF575_16135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PF575_16155	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PF575_16160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PF575_16165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PF575_16175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PF575_16185	COG2969	positive regulation of protein catabolic process
PF575_16205	COG1960	acyl-CoA dehydrogenase activity
PF575_16210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF575_16225	COG1309	transcriptional regulator
PF575_16230	COG1960	acyl-CoA dehydrogenase activity
PF575_16275	COG1183	phosphatidylcholine synthase activity
PF575_16280	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PF575_16310	COG1196	nuclear chromosome segregation
PF575_16310	COG0741	lytic transglycosylase activity
PF575_16310	COG0739	heme binding
PF575_16320	COG1702	phosphate starvation-inducible protein PhoH
PF575_16355	COG1295	ribonuclease BN
PF575_16360	COG0697	spore germination
PF575_16365	COG2169	Transcriptional regulator
PF575_16370	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF575_16415	COG0557	exoribonuclease II activity
PF575_16420	COG0339	signal peptide processing
PF575_16425	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PF575_16455	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PF575_16460	COG1960	acyl-CoA dehydrogenase activity
PF575_16615	COG0626	cystathionine gamma-synthase activity
PF575_16620	COG0433	COG0433 Predicted ATPase
PF575_16630	COG1017	nitric oxide dioxygenase activity
PF575_16630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF575_16635	COG1959	2 iron, 2 sulfur cluster binding
PF575_16650	COG1301	dicarboxylic acid transport
PF575_16655	COG1946	Acyl-CoA thioesterase
PF575_16675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PF575_16680	COG1040	competence protein
PF575_16685	COG0494	nUDIX hydrolase
PF575_16695	COG0598	Magnesium transport protein CorA
PF575_16705	COG2854	intermembrane phospholipid transfer
PF575_16715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PF575_16720	COG1127	ABC transporter
PF575_16730	COG0513	Belongs to the DEAD box helicase family
PF575_16750	COG0408	coproporphyrinogen oxidase activity
PF575_16765	COG1960	acyl-CoA dehydrogenase activity
PF575_16775	COG1983	PspC domain protein
PF575_16780	COG0517	IMP dehydrogenase activity
PF575_16840	COG0583	DNA-binding transcription factor activity
PF575_16880	COG1012	belongs to the aldehyde dehydrogenase family
PF575_16890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF575_16895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF575_16900	COG0833	amino acid
PF575_16930	COG1192	Involved in chromosome partitioning
PF575_16935	COG0628	permease
PF575_16945	COG1289	transmembrane transporter activity
PF575_16960	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF575_16965	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF575_16980	COG0277	FAD linked oxidase domain protein
PF575_16985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF575_17010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PF575_17015	COG5380	lipid catabolic process
PF575_17035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PF575_17085	COG0194	GDP metabolic process
PF575_17100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF575_17120	COG3307	-O-antigen
PF575_17140	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PF575_17145	COG1704	LemA family
PF575_17155	COG0493	'glutamate synthase
PF575_17160	COG0070	glutamate synthase
PF575_17160	COG0069	glutamate synthase activity
PF575_17160	COG0067	glutamate synthase
PF575_17210	COG2226	methyltransferase
PF575_17225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PF575_17230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PF575_17275	COG0833	amino acid
PF575_17340	COG0488	(ABC) transporter
PF575_17350	COG4221	oxidoreductase activity
PF575_17355	COG0659	secondary active sulfate transmembrane transporter activity
PF575_17380	COG0427	acetyl-CoA hydrolase
PF575_17410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PF575_17460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF575_17520	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF575_17525	COG1733	regulation of RNA biosynthetic process
PF575_17555	COG0667	Aldo Keto reductase
PF575_17575	COG0583	DNA-binding transcription factor activity
PF575_17580	COG2814	Major facilitator Superfamily
PF575_17610	COG1335	isochorismatase
PF575_17620	COG1012	belongs to the aldehyde dehydrogenase family
PF575_17625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF575_17635	COG1113	amino acid transport
PF575_17645	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF575_17660	COG2814	Major facilitator Superfamily
PF575_17670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF575_17670	COG0352	thiamine-phosphate diphosphorylase activity
PF575_17670	COG0351	phosphomethylpyrimidine kinase
PF575_17690	COG1309	transcriptional regulator
PF575_17710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF575_17720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF575_17725	COG3162	membrane
PF575_17730	COG2205	protein histidine kinase activity
PF575_17730	COG0784	Response regulator, receiver
PF575_17730	COG2198	Histidine kinase
PF575_17755	COG1522	sequence-specific DNA binding
PF575_17760	COG1335	isochorismatase
PF575_17765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF575_17775	COG0668	transmembrane transport
PF575_17780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF575_17785	COG1519	Transferase
PF575_17790	COG1902	pentaerythritol trinitrate reductase activity
PF575_17815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PF575_17840	COG0426	domain, Protein
PF575_17840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF575_17845	COG4774	siderophore transport
PF575_17850	COG2119	membrane
PF575_17860	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF575_17870	COG4942	peptidase
PF575_17885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PF575_17895	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PF575_17915	COG0189	ligase activity
PF575_17940	COG0708	Exodeoxyribonuclease III
PF575_17945	COG1393	Belongs to the ArsC family
PF575_17960	COG3706	GGDEF domain
PF575_17995	COG2351	hydroxyisourate hydrolase activity
PF575_18000	COG2233	PERMEase
PF575_18010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF575_18020	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
PF575_18030	COG3150	esterase
PF575_18045	COG3179	chitinase
PF575_18065	COG2918	glutathione biosynthetic process
PF575_18080	COG2733	membrane
PF575_18085	COG0436	Aminotransferase
PF575_18090	COG0534	Mate efflux family protein
PF575_18175	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PF575_18180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PF575_18190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PF575_18195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF575_18210	COG0010	Belongs to the arginase family
PF575_18245	COG0251	oxidation-reduction process
PF575_18285	COG0564	pseudouridine synthase activity
PF575_18355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PF575_18370	COG1802	Transcriptional regulator
PF575_18380	COG1448	Aminotransferase
PF575_18385	COG0277	FAD linked oxidase domain protein
PF575_18395	COG2186	Transcriptional regulator
PF575_18405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF575_18410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF575_18425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF575_18430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PF575_18435	COG1216	Glycosyl transferase, family 2
PF575_18455	COG0438	transferase activity, transferring glycosyl groups
PF575_18485	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PF575_18515	COG0728	peptidoglycan biosynthetic process
PF575_18520	COG3023	N-Acetylmuramoyl-L-alanine amidase
PF575_18580	COG0546	phosphoglycolate phosphatase activity
PF575_18585	COG1028	Short-chain dehydrogenase reductase Sdr
PF575_18605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF575_18610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF575_18615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF575_18620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF575_18625	COG1116	anion transmembrane transporter activity
PF575_18630	COG1309	transcriptional regulator
PF575_18635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PF575_18645	COG0196	riboflavin kinase activity
PF575_18650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PF575_18660	COG1047	Peptidyl-prolyl cis-trans
PF575_18700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PF575_18705	COG0657	acetylesterase activity
PF575_18725	COG0583	DNA-binding transcription factor activity
PF575_18755	COG2951	lytic endotransglycosylase activity
PF575_18760	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PF575_18775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PF575_18785	COG0671	phosphoesterase, PA-phosphatase related
PF575_18790	COG0861	Integral membrane protein TerC family
PF575_18800	COG0754	glutathionylspermidine amidase activity
PF575_18810	COG0402	S-adenosylhomocysteine deaminase activity
PF575_18825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF575_18830	COG1230	cation diffusion facilitator family transporter
PF575_18845	COG0706	membrane insertase activity
PF575_18920	COG0358	DNA primase activity
PF575_18960	COG0194	GDP metabolic process
PF575_18985	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PF575_19040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PF575_19085	COG0419	ATPase involved in DNA repair
PF575_19110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF575_19110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PF575_19115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF575_19140	COG0756	dUTP diphosphatase activity
PF575_19360	COG1475	DNA binding
PF575_19365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF575_19475	COG0791	NLP P60 protein