locus-tag	class	description
PF550_00010	COG0592	DNA-directed DNA polymerase activity
PF550_00020	COG0187	DNA topoisomerase II activity
PF550_00030	COG0586	Pfam SNARE associated Golgi protein
PF550_00035	COG0488	(ABC) transporter
PF550_00060	COG0596	Alpha beta hydrolase
PF550_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PF550_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PF550_00110	COG0733	neurotransmitter:sodium symporter activity
PF550_00145	COG0583	DNA-binding transcription factor activity
PF550_00150	COG2233	PERMEase
PF550_00180	COG1192	Involved in chromosome partitioning
PF550_00190	COG0271	Belongs to the BolA IbaG family
PF550_00210	COG4372	Transposase
PF550_00220	COG2963	transposase activity
PF550_00250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PF550_00250	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF550_00250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF550_00250	COG3321	synthase
PF550_00255	COG1960	acyl-CoA dehydrogenase activity
PF550_00265	COG2197	response regulator
PF550_00275	COG3916	Acyl-homoserine-lactone synthase
PF550_00280	COG0477	Major facilitator Superfamily
PF550_00285	COG1024	Enoyl-CoA hydratase
PF550_00290	COG1024	Enoyl-CoA hydratase
PF550_00295	COG1960	acyl-CoA dehydrogenase activity
PF550_00300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF550_00320	COG1113	amino acid transport
PF550_00365	COG2814	Major facilitator Superfamily
PF550_00370	COG0656	L-ascorbic acid biosynthetic process
PF550_00375	COG0583	DNA-binding transcription factor activity
PF550_00390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF550_00395	COG1064	alcohol dehydrogenase
PF550_00400	COG2818	Glycosylase
PF550_00415	COG1194	a g-specific adenine glycosylase
PF550_00435	COG2983	Belongs to the UPF0260 family
PF550_00440	COG2133	pyrroloquinoline quinone binding
PF550_00445	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PF550_00450	COG2116	formate transmembrane transporter activity
PF550_00470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF550_00475	COG1335	isochorismatase
PF550_00480	COG0385	Bile acid
PF550_00490	COG1683	Conserved Protein
PF550_00510	COG0625	glutathione transferase activity
PF550_00520	COG1113	amino acid transport
PF550_00530	COG0523	cobalamin synthesis protein
PF550_00540	COG2188	Transcriptional regulator
PF550_00560	COG1126	abc transporter atp-binding protein
PF550_00585	COG0586	Pfam SNARE associated Golgi protein
PF550_00590	COG2259	Doxx family
PF550_00595	COG4399	Belongs to the UPF0754 family
PF550_00600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF550_00600	COG0519	Catalyzes the synthesis of GMP from XMP
PF550_00645	COG0281	malic enzyme
PF550_00655	COG2837	iron assimilation
PF550_00660	COG1280	lysine exporter protein (LysE YggA)
PF550_00665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF550_00670	COG1121	(ABC) transporter
PF550_00740	COG0386	Belongs to the glutathione peroxidase family
PF550_00755	COG1309	transcriptional regulator
PF550_00760	COG0697	spore germination
PF550_00770	COG0758	DNA mediated transformation
PF550_00840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF550_00850	COG0655	NAD(P)H dehydrogenase (quinone) activity
PF550_00890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF550_00900	COG0477	Major facilitator Superfamily
PF550_00910	COG1253	flavin adenine dinucleotide binding
PF550_00915	COG3012	SEC-C Motif Domain Protein
PF550_00920	COG2860	membrane
PF550_00925	COG0477	Major facilitator Superfamily
PF550_00935	COG0318	PFAM AMP-dependent synthetase and ligase
PF550_00950	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PF550_00970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF550_00975	COG0235	Class ii aldolase
PF550_00980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF550_01010	COG2963	transposase activity
PF550_01020	COG4372	Transposase
PF550_01030	COG1309	transcriptional regulator
PF550_01050	COG1741	Belongs to the pirin family
PF550_01060	COG2964	Protein conserved in bacteria
PF550_01075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF550_01080	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF550_01085	COG4605	iron ion homeostasis
PF550_01090	COG4604	ABC transporter, ATP-binding protein
PF550_01095	COG4607	ABC-type enterochelin transport system periplasmic component
PF550_01100	COG4774	siderophore transport
PF550_01135	COG2217	Heavy metal translocating P-type atpase
PF550_01140	COG2205	protein histidine kinase activity
PF550_01155	COG2132	Multicopper oxidase
PF550_01245	COG0347	Belongs to the P(II) protein family
PF550_01250	COG0004	ammonium transporteR
PF550_01260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF550_01260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF550_01300	COG0795	lipopolysaccharide-transporting ATPase activity
PF550_01305	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PF550_01310	COG0793	Belongs to the peptidase S41A family
PF550_01325	COG2197	response regulator
PF550_01335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PF550_01345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF550_01350	COG4974	Belongs to the 'phage' integrase family
PF550_01375	COG0772	Belongs to the SEDS family
PF550_01380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF550_01385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF550_01390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF550_01415	COG0697	spore germination
PF550_01420	COG1538	Outer membrane efflux protein
PF550_01440	COG3275	phosphorelay sensor kinase activity
PF550_01450	COG0181	hydroxymethylbilane synthase activity
PF550_01495	COG1716	ATPase activity
PF550_01500	COG0546	phosphoglycolate phosphatase activity
PF550_01600	COG2056	Na+-H+ antiporter family
PF550_01615	COG0326	Molecular chaperone. Has ATPase activity
PF550_01630	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF550_01640	COG0789	Transcriptional regulator
PF550_01690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PF550_01695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF550_01695	COG2169	Transcriptional regulator
PF550_01725	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PF550_01735	COG0497	DNA recombination
PF550_01750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF550_01760	COG0237	dephospho-CoA kinase activity
PF550_01810	COG0195	Participates in both transcription termination and antitermination
PF550_01825	COG1320	monovalent cation:proton antiporter activity
PF550_01830	COG2212	antiporter activity
PF550_01835	COG1863	multisubunit Na H antiporter MnhE subunit
PF550_01840	COG0651	ATP synthesis coupled electron transport
PF550_01845	COG1006	Multisubunit Na H antiporter MnhC subunit
PF550_01850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF550_01850	COG2111	Na H antiporter
PF550_01865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PF550_01870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF550_01885	COG2226	methyltransferase
PF550_01905	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PF550_01910	COG1074	ATP-dependent DNA helicase activity
PF550_01915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF550_01920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF550_01935	COG0598	Magnesium transport protein CorA
PF550_01940	COG0789	Transcriptional regulator
PF550_01945	COG0484	heat shock protein binding
PF550_01960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF550_01960	COG0475	glutathione-regulated potassium exporter activity
PF550_01965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF550_01985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF550_01995	COG4535	Mg2 and Co2 transporter CorC
PF550_02000	COG0425	Belongs to the sulfur carrier protein TusA family
PF550_02010	COG0644	oxidoreductase
PF550_02010	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
PF550_02020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF550_02035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF550_02040	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PF550_02050	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF550_02050	COG0493	'glutamate synthase
PF550_02075	COG2963	transposase activity
PF550_02085	COG4372	Transposase
PF550_02095	COG4372	Transposase
PF550_02105	COG2963	transposase activity
PF550_02115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PF550_02130	COG0534	Mate efflux family protein
PF550_02140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF550_02145	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_02150	COG0583	DNA-binding transcription factor activity
PF550_02165	COG0318	PFAM AMP-dependent synthetase and ligase
PF550_02170	COG1530	ribonuclease E activity
PF550_02180	COG0546	phosphoglycolate phosphatase activity
PF550_02185	COG2378	regulation of single-species biofilm formation
PF550_02190	COG0625	glutathione transferase activity
PF550_02200	COG0583	DNA-binding transcription factor activity
PF550_02265	COG0473	3-isopropylmalate dehydrogenase activity
PF550_02320	COG1301	dicarboxylic acid transport
PF550_02330	COG1560	Kdo2-lipid A biosynthetic process
PF550_02335	COG1280	lysine exporter protein (LysE YggA)
PF550_02340	COG0488	(ABC) transporter
PF550_02345	COG2900	Belongs to the SlyX family
PF550_02355	COG1733	regulation of RNA biosynthetic process
PF550_02380	COG0210	DNA helicase
PF550_02385	COG0724	RNA recognition motif
PF550_02405	COG4651	solute:proton antiporter activity
PF550_02405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF550_02430	COG0788	formyltetrahydrofolate deformylase activity
PF550_02530	COG2813	Specifically methylates the guanine in position
PF550_02530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF550_02540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF550_02550	COG4774	siderophore transport
PF550_02560	COG0740	serine-type endopeptidase activity
PF550_02580	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
PF550_02580	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
PF550_02585	COG0280	phosphate acetyltransferase
PF550_02585	COG0857	belongs to the CobB CobQ family
PF550_02590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PF550_02600	COG0800	Aldolase
PF550_02610	COG3265	gluconokinase activity
PF550_02615	COG1012	belongs to the aldehyde dehydrogenase family
PF550_02625	COG2267	carboxylic ester hydrolase activity
PF550_02640	COG0793	Belongs to the peptidase S41A family
PF550_02675	COG1426	Protein conserved in bacteria
PF550_02715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PF550_02725	COG1162	GTPase activity
PF550_02730	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PF550_02745	COG1538	Outer membrane efflux protein
PF550_02750	COG0577	efflux transmembrane transporter activity
PF550_02750	COG1136	(ABC) transporter
PF550_02755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF550_02780	COG0028	Belongs to the TPP enzyme family
PF550_02785	COG0440	acetolactate synthase activity
PF550_02815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PF550_02830	COG0084	hydrolase, TatD family'
PF550_02840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PF550_02850	COG0583	DNA-binding transcription factor activity
PF550_02860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF550_02865	COG2814	Major facilitator Superfamily
PF550_02875	COG0697	spore germination
PF550_02905	COG3622	Belongs to the hyi family
PF550_02910	COG2084	Dehydrogenase
PF550_02915	COG1024	Enoyl-CoA hydratase
PF550_02920	COG5002	protein histidine kinase activity
PF550_02920	COG2205	protein histidine kinase activity
PF550_02920	COG0784	Response regulator, receiver
PF550_02940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF550_02950	COG3956	TIGRFAM MazG family protein
PF550_02955	COG1555	photosystem II stabilization
PF550_02960	COG0617	tRNA 3'-terminal CCA addition
PF550_02965	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PF550_02985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF550_02990	COG3028	Belongs to the UPF0307 family
PF550_02995	COG0318	PFAM AMP-dependent synthetase and ligase
PF550_03010	COG0625	glutathione transferase activity
PF550_03015	COG1238	metal cluster binding
PF550_03060	COG0072	phenylalanine-tRNA ligase activity
PF550_03090	COG0248	Ppx GppA phosphatase
PF550_03100	COG0037	tRNA processing
PF550_03140	COG1764	response to oxidative stress
PF550_03145	COG1846	Transcriptional regulator
PF550_03155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF550_03215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF550_03220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PF550_03225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PF550_03235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF550_03265	COG2963	transposase activity
PF550_03275	COG4372	Transposase
PF550_03305	COG1214	PFAM Peptidase M22, glycoprotease
PF550_03330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PF550_03335	COG0561	phosphatase activity
PF550_03345	COG2132	Multicopper oxidase
PF550_03365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF550_03370	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PF550_03375	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PF550_03405	COG1063	alcohol dehydrogenase
PF550_03410	COG0583	DNA-binding transcription factor activity
PF550_03415	COG1960	acyl-CoA dehydrogenase activity
PF550_03420	COG2814	Major facilitator Superfamily
PF550_03425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PF550_03430	COG1309	transcriptional regulator
PF550_03445	COG1053	succinate dehydrogenase
PF550_03450	COG0583	DNA-binding transcription factor activity
PF550_03465	COG0583	DNA-binding transcription factor activity
PF550_03475	COG0583	DNA-binding transcription factor activity
PF550_03490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF550_03540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF550_03560	COG0745	RESPONSE REGULATOR receiver
PF550_03575	COG3706	GGDEF domain
PF550_03600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PF550_03630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF550_03635	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PF550_03660	COG0583	DNA-binding transcription factor activity
PF550_03680	COG0668	transmembrane transport
PF550_03690	COG2081	HI0933 family
PF550_03695	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PF550_03725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF550_03725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF550_03735	COG0489	protein tyrosine kinase activity
PF550_03785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF550_03795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PF550_03810	COG0730	response to heat
PF550_03820	COG1196	nuclear chromosome segregation
PF550_03840	COG2223	nitrite transmembrane transporter activity
PF550_03845	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
PF550_03850	COG1877	trehalose-phosphatase activity
PF550_03855	COG0596	Alpha beta hydrolase
PF550_03855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF550_03855	COG2226	methyltransferase
PF550_03870	COG4106	trans-aconitate 2-methyltransferase activity
PF550_03885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PF550_03890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PF550_03895	COG0009	L-threonylcarbamoyladenylate synthase
PF550_03900	COG3101	peptidyl-lysine hydroxylation
PF550_03905	COG1399	metal-binding, possibly nucleic acid-binding protein
PF550_03930	COG1652	LysM domain
PF550_03935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF550_03935	COG0351	phosphomethylpyrimidine kinase
PF550_03935	COG0352	thiamine-phosphate diphosphorylase activity
PF550_03945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PF550_03975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF550_04005	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PF550_04020	COG0358	DNA primase activity
PF550_04030	COG0564	pseudouridine synthase activity
PF550_04055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF550_04075	COG0583	DNA-binding transcription factor activity
PF550_04080	COG0473	3-isopropylmalate dehydrogenase activity
PF550_04090	COG0657	acetylesterase activity
PF550_04100	COG1012	belongs to the aldehyde dehydrogenase family
PF550_04120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PF550_04120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF550_04135	COG1981	membrane
PF550_04180	COG0456	acetyltransferase
PF550_04190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PF550_04195	COG0492	ferredoxin-NADP+ reductase activity
PF550_04200	COG1674	ftsk spoiiie
PF550_04200	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PF550_04205	COG1280	lysine exporter protein (LysE YggA)
PF550_04220	COG2894	cell division
PF550_04235	COG0204	Acyl-transferase
PF550_04240	COG2885	chlorophyll binding
PF550_04245	COG0210	DNA helicase
PF550_04255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF550_04270	COG0121	glutamine amidotransferase
PF550_04290	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PF550_04295	COG0735	belongs to the Fur family
PF550_04320	COG0420	3'-5' exonuclease activity
PF550_04340	COG1090	epimerase
PF550_04355	COG2050	protein possibly involved in aromatic compounds catabolism
PF550_04365	COG2814	Major facilitator Superfamily
PF550_04370	COG0405	Gamma-glutamyltransferase
PF550_04380	COG0582	viral genome integration into host DNA
PF550_04425	COG0629	single-stranded DNA binding
PF550_04465	COG4372	Transposase
PF550_04475	COG2963	transposase activity
PF550_04480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PF550_04495	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PF550_04530	COG0477	Major facilitator Superfamily
PF550_04580	COG0531	amino acid
PF550_04585	COG2040	homocysteine
PF550_04600	COG2963	transposase activity
PF550_04610	COG4372	Transposase
PF550_04625	COG1309	transcriptional regulator
PF550_04630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF550_04635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF550_04645	COG1607	acyl-coa hydrolase
PF550_04655	COG0523	cobalamin synthesis protein
PF550_04665	COG4681	YaeQ
PF550_04675	COG1649	PFAM Uncharacterised BCR, COG1649
PF550_04675	COG0726	polysaccharide deacetylase
PF550_04680	COG1215	transferase activity, transferring glycosyl groups
PF550_04690	COG1024	Enoyl-CoA hydratase
PF550_04705	COG1414	Transcriptional regulator
PF550_04725	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_04740	COG2271	Major facilitator Superfamily
PF550_04750	COG2267	carboxylic ester hydrolase activity
PF550_04755	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_04770	COG0028	Belongs to the TPP enzyme family
PF550_04780	COG0477	Major facilitator Superfamily
PF550_04785	COG0242	peptide deformylase activity
PF550_04790	COG2066	Belongs to the glutaminase family
PF550_04795	COG2207	Transcriptional regulator
PF550_04800	COG2223	nitrite transmembrane transporter activity
PF550_04815	COG0583	DNA-binding transcription factor activity
PF550_04820	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_04825	COG2271	Major facilitator Superfamily
PF550_04830	COG3959	Transketolase, thiamine diphosphate binding domain
PF550_04835	COG3958	Transketolase
PF550_04845	COG0306	phosphate transporter
PF550_04865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PF550_04915	COG4181	ATPase activity
PF550_04920	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PF550_04950	COG0583	DNA-binding transcription factor activity
PF550_04960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF550_04965	COG1773	rubredoxin
PF550_05015	COG2851	Citrate transporter
PF550_05020	COG1253	flavin adenine dinucleotide binding
PF550_05060	COG0804	urea catabolic process
PF550_05070	COG0830	nickel cation binding
PF550_05085	COG0742	ribosomal rna small subunit methyltransferase
PF550_05090	COG0768	penicillin binding
PF550_05115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PF550_05120	COG2878	Part of a membrane complex involved in electron transport
PF550_05125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF550_05135	COG3384	dioxygenase
PF550_05160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PF550_05470	COG4372	Transposase
PF550_05480	COG2963	transposase activity
PF550_05490	COG4372	Transposase
PF550_05500	COG2963	transposase activity
PF550_05520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF550_05540	COG0823	Involved in the tonB-independent uptake of proteins
PF550_05560	COG0824	Thioesterase
PF550_05565	COG1473	amidohydrolase
PF550_05585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PF550_05585	COG0047	phosphoribosylformylglycinamidine synthase activity
PF550_05590	COG2814	Major facilitator Superfamily
PF550_05605	COG1024	Enoyl-CoA hydratase
PF550_05610	COG1051	belongs to the nudix hydrolase family
PF550_05610	COG1056	cytidyltransferase-related domain
PF550_05620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PF550_05635	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PF550_05650	COG4625	pathogenesis
PF550_05655	COG0583	DNA-binding transcription factor activity
PF550_05660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PF550_05665	COG4208	sulfate ABC transporter
PF550_05670	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PF550_05680	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PF550_05685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF550_05690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF550_05710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF550_05725	COG0681	Belongs to the peptidase S26 family
PF550_05740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PF550_05750	COG1381	Involved in DNA repair and RecF pathway recombination
PF550_05755	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PF550_05765	COG4221	oxidoreductase activity
PF550_05795	COG0443	Heat shock 70 kDa protein
PF550_05805	COG0436	Aminotransferase
PF550_05825	COG0556	nucleotide-excision repair
PF550_05880	COG2070	2-Nitropropane dioxygenase
PF550_05910	COG1215	transferase activity, transferring glycosyl groups
PF550_05925	COG0415	Belongs to the DNA photolyase family
PF550_05935	COG1252	NADH dehydrogenase
PF550_05940	COG1686	Belongs to the peptidase S11 family
PF550_05955	COG1187	pseudouridine synthase activity
PF550_05980	COG0477	Major facilitator Superfamily
PF550_05985	COG0583	DNA-binding transcription factor activity
PF550_05990	COG1823	symporter activity
PF550_06000	COG0612	Peptidase, M16
PF550_06025	COG4372	Transposase
PF550_06035	COG2963	transposase activity
PF550_06045	COG0352	thiamine-phosphate diphosphorylase activity
PF550_06080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF550_06090	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF550_06105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF550_06110	COG0076	glutamate decarboxylase activity
PF550_06120	COG1522	sequence-specific DNA binding
PF550_06125	COG3961	Belongs to the TPP enzyme family
PF550_06130	COG1113	amino acid transport
PF550_06135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PF550_06140	COG0573	inorganic phosphate transmembrane transporter activity
PF550_06150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF550_06155	COG0616	signal peptide processing
PF550_06190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PF550_06195	COG1686	Belongs to the peptidase S11 family
PF550_06220	COG0583	DNA-binding transcription factor activity
PF550_06225	COG1067	ATP-dependent peptidase activity
PF550_06250	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PF550_06270	COG1966	Carbon starvation protein
PF550_06275	COG2879	small protein
PF550_06325	COG1335	isochorismatase
PF550_06330	COG0583	DNA-binding transcription factor activity
PF550_06345	COG0596	Alpha beta hydrolase
PF550_06355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF550_06365	COG0583	DNA-binding transcription factor activity
PF550_06370	COG1902	pentaerythritol trinitrate reductase activity
PF550_06375	COG0006	proline dipeptidase activity
PF550_06380	COG0477	Major facilitator Superfamily
PF550_06395	COG1012	belongs to the aldehyde dehydrogenase family
PF550_06405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF550_06410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF550_06410	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PF550_06445	COG2814	Major facilitator Superfamily
PF550_06450	COG4948	Mandelate Racemase Muconate Lactonizing
PF550_06460	COG2963	transposase activity
PF550_06470	COG4372	Transposase
PF550_06480	COG1309	transcriptional regulator
PF550_06500	COG1741	Belongs to the pirin family
PF550_06510	COG2964	Protein conserved in bacteria
PF550_06525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF550_06530	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF550_06535	COG4605	iron ion homeostasis
PF550_06540	COG4604	ABC transporter, ATP-binding protein
PF550_06545	COG4607	ABC-type enterochelin transport system periplasmic component
PF550_06550	COG4774	siderophore transport
PF550_06560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF550_06565	COG1021	2,3-dihydroxybenzoate-AMP ligase
PF550_06570	COG3433	isochorismatase activity
PF550_06570	COG1535	isochorismatase
PF550_06580	COG1132	(ABC) transporter
PF550_06585	COG1132	(ABC) transporter
PF550_06590	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
PF550_06595	COG2977	Belongs to the P-Pant transferase superfamily
PF550_06615	COG3739	integral membrane protein
PF550_06630	COG2963	transposase activity
PF550_06640	COG4372	Transposase
PF550_06660	COG0302	gtp cyclohydrolase
PF550_06670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PF550_06700	COG0308	aminopeptidase N
PF550_06705	COG0512	Glutamine amidotransferase of anthranilate synthase
PF550_06860	COG3617	BRO family, N-terminal domain
PF550_07035	COG0741	lytic transglycosylase activity
PF550_07035	COG1196	nuclear chromosome segregation
PF550_07035	COG0739	heme binding
PF550_07090	COG2194	sulfuric ester hydrolase activity
PF550_07125	COG0006	proline dipeptidase activity
PF550_07130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF550_07135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF550_07155	COG1279	arginine transmembrane transporter activity
PF550_07160	COG0583	DNA-binding transcription factor activity
PF550_07200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF550_07205	COG0741	lytic transglycosylase activity
PF550_07205	COG0741	lytic transglycosylase activity
PF550_07205	COG1388	LysM domain
PF550_07205	COG1388	LysM domain
PF550_07215	COG4174	ABC transporter (Permease)
PF550_07220	COG4239	(ABC) transporter, permease
PF550_07225	COG4172	Belongs to the ABC transporter superfamily
PF550_07245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF550_07275	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF550_07275	COG1902	pentaerythritol trinitrate reductase activity
PF550_07290	COG4269	membrane
PF550_07335	COG1113	amino acid transport
PF550_07345	COG0531	amino acid
PF550_07365	COG1012	belongs to the aldehyde dehydrogenase family
PF550_07385	COG1113	amino acid transport
PF550_07400	COG0697	spore germination
PF550_07405	COG2721	sulfolactate sulfo-lyase activity
PF550_07410	COG2271	Major facilitator Superfamily
PF550_07415	COG4948	Mandelate Racemase Muconate Lactonizing
PF550_07425	COG1012	belongs to the aldehyde dehydrogenase family
PF550_07430	COG2186	Transcriptional regulator
PF550_07455	COG1960	acyl-CoA dehydrogenase activity
PF550_07465	COG1012	belongs to the aldehyde dehydrogenase family
PF550_07470	COG1024	Enoyl-CoA hydratase
PF550_07475	COG2814	Major facilitator Superfamily
PF550_07490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF550_07505	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PF550_07550	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
PF550_07555	COG2072	flavoprotein involved in K transport
PF550_07560	COG0300	oxidoreductase activity
PF550_07570	COG1309	transcriptional regulator
PF550_07575	COG1741	Belongs to the pirin family
PF550_07590	COG2072	flavoprotein involved in K transport
PF550_07600	COG2252	PERMEase
PF550_07605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PF550_07610	COG3038	cytochrome b561
PF550_07620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PF550_07630	COG0527	aspartate kinase activity
PF550_07640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF550_07655	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PF550_07670	COG0667	Aldo Keto reductase
PF550_07685	COG1765	OsmC-like protein
PF550_07700	COG0542	response to heat
PF550_07735	COG2885	chlorophyll binding
PF550_07745	COG0625	glutathione transferase activity
PF550_07750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PF550_07770	COG3634	alkyl hydroperoxide reductase activity
PF550_07780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PF550_07790	COG0450	alkyl hydroperoxide reductase
PF550_07795	COG1643	Atp-dependent helicase
PF550_07810	COG2814	Major facilitator Superfamily
PF550_07815	COG3135	benzoate transporter
PF550_07820	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_07825	COG0543	2 iron, 2 sulfur cluster binding
PF550_07825	COG0633	Ferredoxin
PF550_07830	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
PF550_07835	COG4638	Rieske (2fe-2S)
PF550_07845	COG0583	DNA-binding transcription factor activity
PF550_07895	COG1570	exodeoxyribonuclease VII activity
PF550_07925	COG1280	lysine exporter protein (LysE YggA)
PF550_07930	COG1278	Cold shock
PF550_07975	COG2814	Major facilitator Superfamily
PF550_08015	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PF550_08025	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PF550_08030	COG1137	ATPase activity
PF550_08035	COG1538	Outer membrane efflux protein
PF550_08045	COG2963	transposase activity
PF550_08055	COG4372	Transposase
PF550_08085	COG4122	O-methyltransferase activity
PF550_08095	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PF550_08110	COG1522	sequence-specific DNA binding
PF550_08125	COG1560	Kdo2-lipid A biosynthetic process
PF550_08140	COG2814	Major facilitator Superfamily
PF550_08160	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF550_08200	COG0583	DNA-binding transcription factor activity
PF550_08205	COG1914	H( )-stimulated, divalent metal cation uptake system
PF550_08225	COG4770	biotin carboxylase activity
PF550_08230	COG0038	chloride channel
PF550_08235	COG2831	hemolysin activation secretion protein
PF550_08240	COG3210	domain, Protein
PF550_08265	COG1063	alcohol dehydrogenase
PF550_08285	COG0439	Biotin carboxylase
PF550_08290	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF550_08295	COG1733	regulation of RNA biosynthetic process
PF550_08310	COG0864	Transcriptional regulator
PF550_08320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF550_08325	COG1116	anion transmembrane transporter activity
PF550_08440	COG0590	tRNA wobble adenosine to inosine editing
PF550_08445	COG2807	transmembrane transport
PF550_08460	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PF550_08470	COG0789	Transcriptional regulator
PF550_08480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF550_08500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF550_08525	COG1012	belongs to the aldehyde dehydrogenase family
PF550_08530	COG0531	amino acid
PF550_08535	COG1760	l-serine dehydratase
PF550_08540	COG1012	belongs to the aldehyde dehydrogenase family
PF550_08540	COG2030	dehydratase
PF550_08545	COG3396	Phenylacetate-CoA oxygenase
PF550_08550	COG3460	Phenylacetate-CoA oxygenase
PF550_08555	COG3396	Phenylacetate-CoA oxygenase
PF550_08560	COG2151	metal-sulfur cluster biosynthetic enzyme
PF550_08565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF550_08570	COG1024	Enoyl-CoA hydratase
PF550_08575	COG1024	Enoyl-CoA hydratase
PF550_08580	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF550_08585	COG0183	Belongs to the thiolase family
PF550_08590	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PF550_08595	COG3327	negative regulation of DNA-templated transcription, initiation
PF550_08605	COG2050	protein possibly involved in aromatic compounds catabolism
PF550_08635	COG0753	catalase activity
PF550_08640	COG3038	cytochrome b561
PF550_08660	COG2267	carboxylic ester hydrolase activity
PF550_08665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF550_08670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF550_08675	COG1012	belongs to the aldehyde dehydrogenase family
PF550_08685	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF550_08695	COG1012	belongs to the aldehyde dehydrogenase family
PF550_08700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF550_08705	COG0583	DNA-binding transcription factor activity
PF550_08715	COG1414	Transcriptional regulator
PF550_08720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF550_08730	COG1840	ABC-type Fe3 transport system, periplasmic component
PF550_08735	COG3842	ATPase activity
PF550_08750	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PF550_08755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF550_08760	COG2814	Major facilitator Superfamily
PF550_08765	COG1960	acyl-CoA dehydrogenase activity
PF550_08770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PF550_08780	COG1024	Enoyl-CoA hydratase
PF550_08790	COG2814	Major facilitator Superfamily
PF550_08800	COG0183	Belongs to the thiolase family
PF550_08805	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF550_08810	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_08815	COG1024	Enoyl-CoA hydratase
PF550_08820	COG1960	acyl-CoA dehydrogenase activity
PF550_08825	COG2814	Major facilitator Superfamily
PF550_08830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF550_08835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF550_08845	COG2814	Major facilitator Superfamily
PF550_08855	COG1960	acyl-CoA dehydrogenase activity
PF550_08870	COG0583	DNA-binding transcription factor activity
PF550_08880	COG4770	biotin carboxylase activity
PF550_08885	COG1024	Enoyl-CoA hydratase
PF550_08890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF550_08895	COG1960	acyl-CoA dehydrogenase activity
PF550_08900	COG1309	transcriptional regulator
PF550_08905	COG0318	PFAM AMP-dependent synthetase and ligase
PF550_08925	COG0583	DNA-binding transcription factor activity
PF550_08975	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_08995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PF550_09015	COG0784	Response regulator, receiver
PF550_09015	COG2205	protein histidine kinase activity
PF550_09035	COG0765	amino acid transport
PF550_09040	COG0765	amino acid transport
PF550_09045	COG1126	abc transporter atp-binding protein
PF550_09050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF550_09055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF550_09070	COG1280	lysine exporter protein (LysE YggA)
PF550_09075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF550_09080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF550_09085	COG1045	serine acetyltransferase
PF550_09100	COG0583	DNA-binding transcription factor activity
PF550_09105	COG0625	glutathione transferase activity
PF550_09110	COG0625	glutathione transferase activity
PF550_09115	COG0583	DNA-binding transcription factor activity
PF550_09125	COG1346	cytolysis
PF550_09145	COG2814	Major facilitator Superfamily
PF550_09155	COG0583	DNA-binding transcription factor activity
PF550_09165	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
PF550_09170	COG3052	prosthetic group binding
PF550_09190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF550_09210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF550_09220	COG1294	oxidase, subunit
PF550_09225	COG1271	oxidase subunit
PF550_09245	COG0477	Major facilitator Superfamily
PF550_09270	COG4521	taurine ABC transporter
PF550_09275	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PF550_09280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF550_09285	COG2175	clavaminate synthase activity
PF550_09295	COG1953	Uracil, thiamine, allantoin
PF550_09305	COG0583	DNA-binding transcription factor activity
PF550_09315	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PF550_09330	COG0640	Transcriptional regulator
PF550_09335	COG0798	PFAM Bile acid sodium symporter
PF550_09340	COG0583	DNA-binding transcription factor activity
PF550_09355	COG3634	alkyl hydroperoxide reductase activity
PF550_09400	COG0436	Aminotransferase
PF550_09410	COG0386	Belongs to the glutathione peroxidase family
PF550_09425	COG2963	transposase activity
PF550_09435	COG4372	Transposase
PF550_09470	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF550_09495	COG0012	GTP binding
PF550_09500	COG2011	ABC-type metal ion transport system permease component
PF550_09505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF550_09515	COG1464	Belongs to the NlpA lipoprotein family
PF550_09545	COG0765	amino acid transport
PF550_09550	COG0765	amino acid transport
PF550_09555	COG1126	abc transporter atp-binding protein
PF550_09565	COG1522	sequence-specific DNA binding
PF550_09580	COG1309	transcriptional regulator
PF550_09600	COG0583	DNA-binding transcription factor activity
PF550_09610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF550_09625	COG4372	Transposase
PF550_09635	COG2963	transposase activity
PF550_09665	COG3121	Chaperone
PF550_09670	COG3539	Fimbrial protein
PF550_09695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PF550_09695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PF550_09725	COG2963	transposase activity
PF550_09735	COG4372	Transposase
PF550_09765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PF550_09775	COG2353	YceI-like domain
PF550_09785	COG3698	Phosphodiester glycosidase
PF550_09800	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PF550_09805	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PF550_09805	COG0506	proline dehydrogenase activity
PF550_09805	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PF550_09815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF550_09820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PF550_09840	COG1132	(ABC) transporter
PF550_09845	COG3122	Protein conserved in bacteria
PF550_09850	COG3619	membrane
PF550_09860	COG0640	Transcriptional regulator
PF550_09870	COG2850	peptidyl-arginine hydroxylation
PF550_09875	COG0424	maF-like protein
PF550_09895	COG0191	fructose-bisphosphate aldolase activity
PF550_09900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF550_09915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PF550_09925	COG1192	Involved in chromosome partitioning
PF550_09930	COG1475	DNA binding
PF550_09935	COG0811	peptide transport
PF550_09945	COG1132	(ABC) transporter
PF550_09950	COG1663	tetraacyldisaccharide 4'-kinase activity
PF550_09970	COG0084	hydrolase, TatD family'
PF550_10035	COG0776	regulation of translation
PF550_10065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PF550_10070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PF550_10120	COG0339	signal peptide processing
PF550_10130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF550_10165	COG0702	epimerase
PF550_10170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PF550_10190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PF550_10205	COG4372	Transposase
PF550_10215	COG2963	transposase activity
PF550_10235	COG0316	Belongs to the HesB IscA family
PF550_10240	COG0822	iron-sulfur transferase activity
PF550_10265	COG0776	regulation of translation
PF550_10270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF550_10275	COG2207	Transcriptional regulator
PF550_10280	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF550_10285	COG1960	acyl-CoA dehydrogenase activity
PF550_10290	COG1960	acyl-CoA dehydrogenase activity
PF550_10305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PF550_10325	COG4264	IucA IucC family
PF550_10330	COG4264	IucA IucC family
PF550_10340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PF550_10370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF550_10385	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PF550_10405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PF550_10410	COG0730	response to heat
PF550_10430	COG4773	Receptor
PF550_10435	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF550_10450	COG1131	(ABC) transporter
PF550_10455	COG0842	Transport permease protein
PF550_10460	COG0842	Transport permease protein
PF550_10480	COG2963	transposase activity
PF550_10490	COG4372	Transposase
PF550_10530	COG2226	methyltransferase
PF550_10555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PF550_10590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF550_10600	COG0133	tryptophan synthase activity
PF550_10615	COG2963	transposase activity
PF550_10625	COG4372	Transposase
PF550_10630	COG3706	GGDEF domain
PF550_10645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF550_10650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF550_10655	COG0022	dehydrogenase e1 component
PF550_10660	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF550_10665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF550_10675	COG1063	alcohol dehydrogenase
PF550_10680	COG3781	membrane
PF550_10690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF550_10690	COG3453	Protein conserved in bacteria
PF550_10705	COG0730	response to heat
PF550_10720	COG2207	Transcriptional regulator
PF550_10720	COG3708	Transcriptional regulator
PF550_10725	COG1733	regulation of RNA biosynthetic process
PF550_10730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF550_10740	COG2188	Transcriptional regulator
PF550_10755	COG4521	taurine ABC transporter
PF550_10780	COG0477	Major facilitator Superfamily
PF550_10790	COG1027	Aspartate ammonia-lyase
PF550_10805	COG0583	DNA-binding transcription factor activity
PF550_10810	COG0583	DNA-binding transcription factor activity
PF550_10815	COG0183	Belongs to the thiolase family
PF550_10820	COG2031	fatty acid transporter
PF550_10835	COG0583	DNA-binding transcription factor activity
PF550_10855	COG1309	transcriptional regulator
PF550_10865	COG2610	gluconate transmembrane transporter activity
PF550_10870	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_10875	COG2207	Transcriptional regulator
PF550_10890	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_10900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF550_10915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF550_10915	COG0543	2 iron, 2 sulfur cluster binding
PF550_10920	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
PF550_10925	COG4638	Rieske (2fe-2S)
PF550_10935	COG0725	ABC transporter, periplasmic molybdate-binding protein
PF550_10940	COG4149	molybdate abc transporter
PF550_10945	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PF550_10950	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_10955	COG3433	isochorismatase activity
PF550_10955	COG1535	isochorismatase
PF550_11025	COG2963	transposase activity
PF550_11035	COG4372	Transposase
PF550_11055	COG0753	catalase activity
PF550_11065	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PF550_11120	COG1414	Transcriptional regulator
PF550_11135	COG4372	Transposase
PF550_11145	COG2963	transposase activity
PF550_11155	COG0477	Major facilitator Superfamily
PF550_11190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF550_11225	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PF550_11280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF550_11300	COG1120	ATPase activity
PF550_11305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF550_11315	COG1064	alcohol dehydrogenase
PF550_11330	COG2207	Transcriptional regulator
PF550_11335	COG2084	Dehydrogenase
PF550_11345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF550_11350	COG0583	DNA-binding transcription factor activity
PF550_11360	COG0129	dihydroxy-acid dehydratase activity
PF550_11365	COG1012	belongs to the aldehyde dehydrogenase family
PF550_11380	COG1566	PFAM secretion protein HlyD family protein
PF550_11405	COG0583	DNA-binding transcription factor activity
PF550_11420	COG2188	Transcriptional regulator
PF550_11455	COG4191	Histidine kinase
PF550_11470	COG1473	amidohydrolase
PF550_11480	COG0475	glutathione-regulated potassium exporter activity
PF550_11480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF550_11490	COG0583	DNA-binding transcription factor activity
PF550_11495	COG1335	isochorismatase
PF550_11505	COG1309	transcriptional regulator
PF550_11545	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF550_11545	COG1902	pentaerythritol trinitrate reductase activity
PF550_11560	COG1012	belongs to the aldehyde dehydrogenase family
PF550_11580	COG2186	Transcriptional regulator
PF550_11590	COG0583	DNA-binding transcription factor activity
PF550_11595	COG4948	Mandelate Racemase Muconate Lactonizing
PF550_11600	COG4829	muconolactone delta-isomerase
PF550_11610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF550_11615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF550_11620	COG0183	Belongs to the thiolase family
PF550_11625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF550_11635	COG1012	belongs to the aldehyde dehydrogenase family
PF550_11645	COG3733	amine oxidase
PF550_11655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF550_11665	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_11675	COG4638	Rieske (2fe-2S)
PF550_11695	COG0154	amidase activity
PF550_11705	COG2814	Major facilitator Superfamily
PF550_11730	COG1960	acyl-CoA dehydrogenase activity
PF550_11735	COG0583	DNA-binding transcription factor activity
PF550_11740	COG1414	Transcriptional regulator
PF550_11755	COG2391	methyltransferase activity
PF550_11765	COG4993	Dehydrogenase
PF550_11770	COG3659	wide pore channel activity
PF550_11775	COG3420	alginic acid biosynthetic process
PF550_11780	COG0710	3-dehydroquinate dehydratase activity
PF550_11785	COG3485	protocatechuate 3,4-dioxygenase
PF550_11790	COG3485	protocatechuate 3,4-dioxygenase
PF550_11795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF550_11800	COG2271	Major facilitator Superfamily
PF550_11805	COG0596	Alpha beta hydrolase
PF550_11810	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PF550_11815	COG0183	Belongs to the thiolase family
PF550_11820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF550_11825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF550_11835	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PF550_11840	COG2323	membrane
PF550_11885	COG1902	pentaerythritol trinitrate reductase activity
PF550_11885	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF550_11910	COG0542	response to heat
PF550_11915	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PF550_11945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF550_11950	COG0569	domain protein
PF550_11955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PF550_11970	COG4774	siderophore transport
PF550_11975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF550_11985	COG1585	Membrane protein implicated in regulation of membrane protease activity
PF550_11990	COG2963	transposase activity
PF550_12000	COG4372	Transposase
PF550_12015	COG1294	oxidase, subunit
PF550_12020	COG4890	Cyd operon protein YbgT
PF550_12030	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
PF550_12040	COG0552	protein localization to endoplasmic reticulum
PF550_12065	COG0517	IMP dehydrogenase activity
PF550_12065	COG0516	GMP reductase activity
PF550_12070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF550_12075	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PF550_12085	COG0583	DNA-binding transcription factor activity
PF550_12090	COG0024	Methionine aminopeptidase
PF550_12120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PF550_12120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF550_12125	COG1105	Belongs to the carbohydrate kinase PfkB family
PF550_12130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF550_12130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF550_12130	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PF550_12145	COG3300	MHYT domain
PF550_12145	COG5001	Diguanylate cyclase
PF550_12155	COG4372	Transposase
PF550_12165	COG2963	transposase activity
PF550_12180	COG2135	peptidase activity
PF550_12185	COG0659	secondary active sulfate transmembrane transporter activity
PF550_12190	COG2963	transposase activity
PF550_12200	COG4372	Transposase
PF550_12225	COG1113	amino acid transport
PF550_12235	COG1522	sequence-specific DNA binding
PF550_12260	COG1011	Hydrolase
PF550_12265	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PF550_12275	COG2137	regulation of response to DNA damage stimulus
PF550_12290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF550_12325	COG0575	Belongs to the CDS family
PF550_12330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PF550_12355	COG3852	Histidine kinase
PF550_12360	COG2204	response regulator
PF550_12430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF550_12435	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PF550_12455	COG0697	spore germination
PF550_12460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF550_12470	COG0303	'Molybdopterin
PF550_12475	COG0315	cyclic pyranopterin monophosphate synthase activity
PF550_12475	COG0521	Mo-molybdopterin cofactor biosynthetic process
PF550_12490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PF550_12495	COG0243	molybdopterin cofactor binding
PF550_12505	COG0243	molybdopterin cofactor binding
PF550_12510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF550_12515	COG2146	nitrite reductase [NAD(P)H] activity
PF550_12515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF550_12525	COG0745	RESPONSE REGULATOR receiver
PF550_12530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF550_12530	COG1116	anion transmembrane transporter activity
PF550_12545	COG0511	ligase activity, forming carbon-carbon bonds
PF550_12560	COG2814	Major facilitator Superfamily
PF550_12580	COG0069	glutamate synthase activity
PF550_12600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF550_12610	COG1454	alcohol dehydrogenase
PF550_12615	COG0824	Thioesterase
PF550_12630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PF550_12645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF550_12650	COG2030	dehydratase
PF550_12660	COG0183	Belongs to the thiolase family
PF550_12670	COG0583	DNA-binding transcription factor activity
PF550_12675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PF550_12685	COG4372	Transposase
PF550_12695	COG2963	transposase activity
PF550_12705	COG1522	sequence-specific DNA binding
PF550_12710	COG3135	benzoate transporter
PF550_12720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PF550_12745	COG0589	response to stress
PF550_12750	COG0488	(ABC) transporter
PF550_12770	COG4773	Receptor
PF550_12800	COG0668	transmembrane transport
PF550_12810	COG1309	transcriptional regulator
PF550_12825	COG1605	Chorismate mutase
PF550_12865	COG0308	aminopeptidase N
PF550_12885	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
PF550_12895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF550_12900	COG1454	alcohol dehydrogenase
PF550_12920	COG0531	amino acid
PF550_12925	COG4303	Ethanolamine ammonia lyase large subunit
PF550_12930	COG4302	ethanolamine ammonia-lyase activity
PF550_12935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF550_12935	COG0519	Catalyzes the synthesis of GMP from XMP
PF550_12940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF550_12950	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF550_12965	COG0697	spore germination
PF550_12970	COG1923	regulation of RNA biosynthetic process
PF550_12980	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PF550_12985	COG0802	atpase or kinase
PF550_13005	COG1187	pseudouridine synthase activity
PF550_13020	COG0583	DNA-binding transcription factor activity
PF550_13035	COG2814	Major facilitator Superfamily
PF550_13040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF550_13065	COG0729	surface antigen
PF550_13085	COG0174	glutamine synthetase
PF550_13090	COG0745	RESPONSE REGULATOR receiver
PF550_13095	COG2205	protein histidine kinase activity
PF550_13105	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
PF550_13110	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PF550_13120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PF550_13135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF550_13140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF550_13145	COG1960	acyl-CoA dehydrogenase activity
PF550_13175	COG0583	DNA-binding transcription factor activity
PF550_13190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF550_13200	COG3658	cytochrome
PF550_13205	COG1215	transferase activity, transferring glycosyl groups
PF550_13210	COG0726	polysaccharide deacetylase
PF550_13210	COG1649	PFAM Uncharacterised BCR, COG1649
PF550_13235	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF550_13240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF550_13250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PF550_13275	COG0305	Participates in initiation and elongation during chromosome replication
PF550_13280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF550_13290	COG1305	Transglutaminase-like
PF550_13300	COG2308	Evidence 4 Homologs of previously reported genes of
PF550_13330	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PF550_13335	COG0138	bifunctional purine biosynthesis protein purh
PF550_13340	COG0151	Belongs to the GarS family
PF550_13345	COG1464	Belongs to the NlpA lipoprotein family
PF550_13350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF550_13355	COG2011	ABC-type metal ion transport system permease component
PF550_13360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF550_13370	COG1301	dicarboxylic acid transport
PF550_13405	COG1794	racemase activity, acting on amino acids and derivatives
PF550_13415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PF550_13415	COG3008	intermembrane lipid transfer
PF550_13420	COG2995	paraquat-inducible protein a
PF550_13450	COG1051	belongs to the nudix hydrolase family
PF550_13455	COG0477	Major facilitator Superfamily
PF550_13525	COG3210	domain, Protein
PF550_13525	COG3210	domain, Protein
PF550_13530	COG2831	hemolysin activation secretion protein
PF550_13555	COG0515	serine threonine protein kinase
PF550_13555	COG2815	serine threonine protein kinase
PF550_13585	COG1610	YqeY-like protein
PF550_13590	COG4783	chaperone-mediated protein folding
PF550_13615	COG1286	toxin biosynthetic process
PF550_13645	COG0778	Nitroreductase
PF550_13655	COG0513	Belongs to the DEAD box helicase family
PF550_13680	COG2363	Small membrane protein
PF550_13710	COG1234	tRNA 3'-trailer cleavage
PF550_13715	COG2195	Cleaves the N-terminal amino acid of tripeptides
PF550_13725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PF550_13735	COG2819	hydrolase of the alpha beta superfamily
PF550_13740	COG1960	acyl-CoA dehydrogenase activity
PF550_13745	COG1301	dicarboxylic acid transport
PF550_13750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PF550_13755	COG3139	Protein of unknown function (DUF1315)
PF550_13760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF550_13765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF550_13775	COG0494	nUDIX hydrolase
PF550_13785	COG0642	Histidine kinase
PF550_13820	COG1720	tRNA m6t6A37 methyltransferase activity
PF550_13830	COG0384	phenazine biosynthesis protein PhzF
PF550_13835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF550_13840	COG0826	peptidase U32
PF550_13845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF550_13855	COG4598	ABC transporter
PF550_13860	COG4160	amino acid transport
PF550_13865	COG4215	(ABC) transporter
PF550_13880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF550_13925	COG1131	(ABC) transporter
PF550_13930	COG0842	Transport permease protein
PF550_13945	COG0772	Belongs to the SEDS family
PF550_13950	COG2951	lytic endotransglycosylase activity
PF550_13975	COG2207	Transcriptional regulator
PF550_13990	COG0052	Belongs to the universal ribosomal protein uS2 family
PF550_13995	COG0024	Methionine aminopeptidase
PF550_14005	COG2223	nitrite transmembrane transporter activity
PF550_14015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF550_14020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF550_14025	COG1960	acyl-CoA dehydrogenase activity
PF550_14040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PF550_14045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PF550_14050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF550_14070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF550_14075	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PF550_14080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF550_14115	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PF550_14125	COG0174	glutamine synthetase
PF550_14140	COG0582	viral genome integration into host DNA
PF550_14210	COG2963	transposase activity
PF550_14220	COG4372	Transposase
PF550_14240	COG0628	permease
PF550_14250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PF550_14255	COG0596	Alpha beta hydrolase
PF550_14260	COG0616	signal peptide processing
PF550_14260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PF550_14270	COG0658	competence protein
PF550_14270	COG2333	competence protein COMEC
PF550_14275	COG1136	(ABC) transporter
PF550_14280	COG4591	ABC-type transport system involved in lipoprotein release permease component
PF550_14315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF550_14335	COG0463	Glycosyl transferase, family 2
PF550_14365	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PF550_14370	COG1280	lysine exporter protein (LysE YggA)
PF550_14380	COG0019	diaminopimelate decarboxylase activity
PF550_14390	COG1113	amino acid transport
PF550_14405	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PF550_14415	COG3339	Conserved Protein
PF550_14420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PF550_14425	COG0243	molybdopterin cofactor binding
PF550_14430	COG1929	Belongs to the glycerate kinase type-1 family
PF550_14445	COG0778	Nitroreductase
PF550_14465	COG3811	Belongs to the UPF0386 family
PF550_14490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PF550_14510	COG0741	lytic transglycosylase activity
PF550_14530	COG0584	glycerophosphoryl diester phosphodiesterase
PF550_14535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF550_14560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF550_14565	COG1597	lipid kinase activity
PF550_14580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PF550_14585	COG0477	Major facilitator Superfamily
PF550_14635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PF550_14640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF550_14665	COG0505	Belongs to the CarA family
PF550_14685	COG0589	response to stress
PF550_14700	COG2843	Capsule synthesis protein
PF550_14720	COG2321	neutral zinc metallopeptidase
PF550_14725	COG2354	Protein conserved in bacteria
PF550_14745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF550_14770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PF550_14775	COG1053	succinate dehydrogenase
PF550_14780	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PF550_14785	COG2009	succinate dehydrogenase
PF550_14825	COG2921	Belongs to the UPF0250 family
PF550_14830	COG0321	lipoyl(octanoyl) transferase activity
PF550_14845	COG0531	amino acid
PF550_14855	COG1733	regulation of RNA biosynthetic process
PF550_14860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PF550_14865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF550_14865	COG1648	precorrin-2 dehydrogenase activity
PF550_14880	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PF550_14910	COG0671	phosphoesterase, PA-phosphatase related
PF550_14915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF550_14925	COG1538	Outer membrane efflux protein
PF550_14930	COG0393	Putative heavy-metal-binding
PF550_14935	COG0393	Putative heavy-metal-binding
PF550_14945	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_14955	COG0525	valine-tRNA ligase activity
PF550_14960	COG2226	methyltransferase
PF550_14975	COG0583	DNA-binding transcription factor activity
PF550_14980	COG0004	ammonium transporteR
PF550_14990	COG0642	Histidine kinase
PF550_14995	COG0745	RESPONSE REGULATOR receiver
PF550_15005	COG2963	transposase activity
PF550_15015	COG4372	Transposase
PF550_15030	COG4372	Transposase
PF550_15040	COG2963	transposase activity
PF550_15055	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF550_15070	COG2315	Protein conserved in bacteria
PF550_15075	COG0142	geranyltranstransferase activity
PF550_15080	COG2828	Protein conserved in bacteria
PF550_15085	COG1113	amino acid transport
PF550_15130	COG2207	Transcriptional regulator
PF550_15155	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF550_15165	COG0560	Phosphoserine phosphatase
PF550_15175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF550_15185	COG1530	ribonuclease E activity
PF550_15190	COG0424	maF-like protein
PF550_15195	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PF550_15200	COG1792	Involved in formation and maintenance of cell shape
PF550_15205	COG1077	Cell shape determining protein MreB Mrl
PF550_15210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF550_15220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF550_15245	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
PF550_15250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF550_15255	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF550_15260	COG1115	amino acid carrier protein
PF550_15280	COG2814	Major facilitator Superfamily
PF550_15285	COG1289	transmembrane transporter activity
PF550_15295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF550_15335	COG1376	ErfK ybiS ycfS ynhG family protein
PF550_15340	COG2832	Protein of unknown function (DUF454)
PF550_15350	COG5510	response to toxic substance
PF550_15370	COG0840	transmembrane signaling receptor activity
PF550_15410	COG3422	double-strand break repair
PF550_15415	COG2824	Alkylphosphonate utilization operon protein PhnA
PF550_15420	COG3189	MarR family transcriptional regulator
PF550_15430	COG0354	folic acid binding
PF550_15435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF550_15445	COG0679	Auxin Efflux Carrier
PF550_15450	COG1902	pentaerythritol trinitrate reductase activity
PF550_15455	COG4772	TonB-dependent receptor
PF550_15460	COG2094	Belongs to the DNA glycosylase MPG family
PF550_15485	COG1217	gtp-binding protein TYPA
PF550_15490	COG2233	PERMEase
PF550_15500	COG0833	amino acid
PF550_15505	COG1690	Belongs to the RtcB family
PF550_15515	COG2885	chlorophyll binding
PF550_15515	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PF550_15525	COG0183	Belongs to the thiolase family
PF550_15545	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF550_15565	COG2207	Transcriptional regulator
PF550_15570	COG0183	Belongs to the thiolase family
PF550_15600	COG1272	protein, Hemolysin III
PF550_15605	COG0477	Major facilitator Superfamily
PF550_15620	COG0450	alkyl hydroperoxide reductase
PF550_15640	COG0285	dihydrofolate synthase activity
PF550_15690	COG2096	Adenosyltransferase
PF550_15710	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PF550_15715	COG0745	RESPONSE REGULATOR receiver
PF550_15720	COG2205	protein histidine kinase activity
PF550_15730	COG1960	acyl-CoA dehydrogenase activity
PF550_15735	COG1960	acyl-CoA dehydrogenase activity
PF550_15800	COG0438	transferase activity, transferring glycosyl groups
PF550_15805	COG0463	Glycosyl transferase, family 2
PF550_15810	COG0726	polysaccharide deacetylase
PF550_15830	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PF550_15835	COG2205	protein histidine kinase activity
PF550_15865	COG1862	Preprotein translocase
PF550_15875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF550_15880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PF550_15890	COG3781	membrane
PF550_15895	COG0613	PHP domain protein
PF550_15905	COG2350	Protein conserved in bacteria
PF550_15935	COG1607	acyl-coa hydrolase
PF550_15995	COG2199	diguanylate cyclase activity
PF550_16005	COG1408	metallophosphoesterase
PF550_16010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF550_16020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PF550_16040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PF550_16045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PF550_16050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PF550_16060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PF550_16070	COG2969	positive regulation of protein catabolic process
PF550_16090	COG1960	acyl-CoA dehydrogenase activity
PF550_16095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF550_16110	COG1309	transcriptional regulator
PF550_16115	COG1960	acyl-CoA dehydrogenase activity
PF550_16160	COG1183	phosphatidylcholine synthase activity
PF550_16165	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PF550_16195	COG1196	nuclear chromosome segregation
PF550_16195	COG0741	lytic transglycosylase activity
PF550_16195	COG0739	heme binding
PF550_16205	COG1702	phosphate starvation-inducible protein PhoH
PF550_16240	COG1295	ribonuclease BN
PF550_16245	COG0697	spore germination
PF550_16250	COG2169	Transcriptional regulator
PF550_16255	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF550_16300	COG0557	exoribonuclease II activity
PF550_16305	COG0339	signal peptide processing
PF550_16310	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PF550_16340	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PF550_16345	COG1960	acyl-CoA dehydrogenase activity
PF550_16500	COG0626	cystathionine gamma-synthase activity
PF550_16505	COG0433	COG0433 Predicted ATPase
PF550_16515	COG1017	nitric oxide dioxygenase activity
PF550_16515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF550_16520	COG1959	2 iron, 2 sulfur cluster binding
PF550_16535	COG1301	dicarboxylic acid transport
PF550_16540	COG1946	Acyl-CoA thioesterase
PF550_16560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PF550_16565	COG1040	competence protein
PF550_16570	COG0494	nUDIX hydrolase
PF550_16580	COG0598	Magnesium transport protein CorA
PF550_16590	COG2854	intermembrane phospholipid transfer
PF550_16600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PF550_16605	COG1127	ABC transporter
PF550_16615	COG0513	Belongs to the DEAD box helicase family
PF550_16635	COG0408	coproporphyrinogen oxidase activity
PF550_16650	COG1960	acyl-CoA dehydrogenase activity
PF550_16660	COG1983	PspC domain protein
PF550_16665	COG0517	IMP dehydrogenase activity
PF550_16725	COG0583	DNA-binding transcription factor activity
PF550_16765	COG1012	belongs to the aldehyde dehydrogenase family
PF550_16775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF550_16780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF550_16785	COG0833	amino acid
PF550_16815	COG1192	Involved in chromosome partitioning
PF550_16820	COG0628	permease
PF550_16830	COG1289	transmembrane transporter activity
PF550_16845	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF550_16850	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF550_16865	COG0277	FAD linked oxidase domain protein
PF550_16870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF550_16895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PF550_16900	COG5380	lipid catabolic process
PF550_16920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PF550_16970	COG0194	GDP metabolic process
PF550_16985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF550_17005	COG3307	-O-antigen
PF550_17025	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PF550_17030	COG1704	LemA family
PF550_17040	COG0493	'glutamate synthase
PF550_17045	COG0067	glutamate synthase
PF550_17045	COG0069	glutamate synthase activity
PF550_17045	COG0070	glutamate synthase
PF550_17095	COG2226	methyltransferase
PF550_17110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PF550_17115	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PF550_17160	COG0833	amino acid
PF550_17225	COG0488	(ABC) transporter
PF550_17235	COG4221	oxidoreductase activity
PF550_17240	COG0659	secondary active sulfate transmembrane transporter activity
PF550_17265	COG0427	acetyl-CoA hydrolase
PF550_17295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PF550_17345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF550_17405	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF550_17410	COG1733	regulation of RNA biosynthetic process
PF550_17440	COG0667	Aldo Keto reductase
PF550_17460	COG0583	DNA-binding transcription factor activity
PF550_17465	COG2814	Major facilitator Superfamily
PF550_17500	COG1335	isochorismatase
PF550_17510	COG1012	belongs to the aldehyde dehydrogenase family
PF550_17515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF550_17525	COG1113	amino acid transport
PF550_17535	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF550_17550	COG2814	Major facilitator Superfamily
PF550_17560	COG0351	phosphomethylpyrimidine kinase
PF550_17560	COG0352	thiamine-phosphate diphosphorylase activity
PF550_17560	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF550_17580	COG1309	transcriptional regulator
PF550_17600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF550_17610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF550_17615	COG3162	membrane
PF550_17620	COG0784	Response regulator, receiver
PF550_17620	COG2198	Histidine kinase
PF550_17620	COG2205	protein histidine kinase activity
PF550_17645	COG1522	sequence-specific DNA binding
PF550_17650	COG1335	isochorismatase
PF550_17655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF550_17665	COG0668	transmembrane transport
PF550_17670	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF550_17675	COG1519	Transferase
PF550_17680	COG1902	pentaerythritol trinitrate reductase activity
PF550_17705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PF550_17730	COG0426	domain, Protein
PF550_17730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF550_17735	COG4774	siderophore transport
PF550_17740	COG2119	membrane
PF550_17750	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF550_17760	COG4942	peptidase
PF550_17775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PF550_17785	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PF550_17805	COG0189	ligase activity
PF550_17830	COG0708	Exodeoxyribonuclease III
PF550_17835	COG1393	Belongs to the ArsC family
PF550_17850	COG3706	GGDEF domain
PF550_17885	COG2351	hydroxyisourate hydrolase activity
PF550_17890	COG2233	PERMEase
PF550_17900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF550_17910	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
PF550_17920	COG3150	esterase
PF550_17935	COG3179	chitinase
PF550_17950	COG2918	glutathione biosynthetic process
PF550_17965	COG2733	membrane
PF550_17970	COG0436	Aminotransferase
PF550_17975	COG0534	Mate efflux family protein
PF550_18060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PF550_18065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PF550_18075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PF550_18080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF550_18095	COG0010	Belongs to the arginase family
PF550_18130	COG0251	oxidation-reduction process
PF550_18170	COG0564	pseudouridine synthase activity
PF550_18240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PF550_18255	COG1802	Transcriptional regulator
PF550_18265	COG1448	Aminotransferase
PF550_18270	COG0277	FAD linked oxidase domain protein
PF550_18280	COG2186	Transcriptional regulator
PF550_18290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF550_18295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF550_18310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF550_18315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PF550_18320	COG1216	Glycosyl transferase, family 2
PF550_18340	COG0438	transferase activity, transferring glycosyl groups
PF550_18370	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PF550_18400	COG0728	peptidoglycan biosynthetic process
PF550_18405	COG3023	N-Acetylmuramoyl-L-alanine amidase
PF550_18465	COG0546	phosphoglycolate phosphatase activity
PF550_18470	COG1028	Short-chain dehydrogenase reductase Sdr
PF550_18490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF550_18495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF550_18500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF550_18505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF550_18510	COG1116	anion transmembrane transporter activity
PF550_18515	COG1309	transcriptional regulator
PF550_18520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PF550_18530	COG0196	riboflavin kinase activity
PF550_18535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PF550_18545	COG1047	Peptidyl-prolyl cis-trans
PF550_18585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PF550_18590	COG0657	acetylesterase activity
PF550_18610	COG0583	DNA-binding transcription factor activity
PF550_18640	COG2951	lytic endotransglycosylase activity
PF550_18645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PF550_18660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PF550_18670	COG0671	phosphoesterase, PA-phosphatase related
PF550_18675	COG0861	Integral membrane protein TerC family
PF550_18685	COG0754	glutathionylspermidine amidase activity
PF550_18695	COG0402	S-adenosylhomocysteine deaminase activity
PF550_18710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF550_18715	COG1230	cation diffusion facilitator family transporter
PF550_18730	COG0706	membrane insertase activity
PF550_18760	COG0791	NLP P60 protein
PF550_18865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF550_18870	COG1475	DNA binding
PF550_19085	COG0756	dUTP diphosphatase activity
PF550_19110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF550_19115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF550_19115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PF550_19140	COG0419	ATPase involved in DNA repair
PF550_19185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PF550_19240	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PF550_19265	COG0194	GDP metabolic process
PF550_19305	COG0358	DNA primase activity