locus-tag	class	description
PF547_00010	COG0592	DNA-directed DNA polymerase activity
PF547_00020	COG0187	DNA topoisomerase II activity
PF547_00030	COG0586	Pfam SNARE associated Golgi protein
PF547_00035	COG0488	(ABC) transporter
PF547_00060	COG0596	Alpha beta hydrolase
PF547_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PF547_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PF547_00110	COG0733	neurotransmitter:sodium symporter activity
PF547_00150	COG2233	PERMEase
PF547_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF547_00200	COG2814	Major facilitator Superfamily
PF547_00205	COG0656	L-ascorbic acid biosynthetic process
PF547_00210	COG0583	DNA-binding transcription factor activity
PF547_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF547_00230	COG1064	alcohol dehydrogenase
PF547_00235	COG2818	Glycosylase
PF547_00250	COG1194	a g-specific adenine glycosylase
PF547_00270	COG2983	Belongs to the UPF0260 family
PF547_00275	COG2133	pyrroloquinoline quinone binding
PF547_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PF547_00285	COG2116	formate transmembrane transporter activity
PF547_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF547_00310	COG1335	isochorismatase
PF547_00315	COG0385	Bile acid
PF547_00320	COG0534	Mate efflux family protein
PF547_00325	COG1683	Conserved Protein
PF547_00345	COG0625	glutathione transferase activity
PF547_00355	COG1113	amino acid transport
PF547_00365	COG0523	cobalamin synthesis protein
PF547_00375	COG2188	Transcriptional regulator
PF547_00405	COG0010	Belongs to the arginase family
PF547_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF547_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PF547_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PF547_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PF547_00540	COG0534	Mate efflux family protein
PF547_00545	COG0436	Aminotransferase
PF547_00550	COG2733	membrane
PF547_00565	COG2918	glutathione biosynthetic process
PF547_00580	COG0791	NLP P60 protein
PF547_00580	COG1388	LysM domain
PF547_00595	COG3150	esterase
PF547_00605	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
PF547_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF547_00630	COG2233	PERMEase
PF547_00635	COG2351	hydroxyisourate hydrolase activity
PF547_00670	COG3706	GGDEF domain
PF547_00685	COG1393	Belongs to the ArsC family
PF547_00690	COG0708	Exodeoxyribonuclease III
PF547_00710	COG0189	ligase activity
PF547_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PF547_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PF547_00755	COG4942	peptidase
PF547_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF547_00775	COG2119	membrane
PF547_00780	COG4774	siderophore transport
PF547_00785	COG0426	domain, Protein
PF547_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF547_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PF547_00830	COG1902	pentaerythritol trinitrate reductase activity
PF547_00835	COG1519	Transferase
PF547_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF547_00845	COG0668	transmembrane transport
PF547_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF547_00860	COG1335	isochorismatase
PF547_00865	COG1522	sequence-specific DNA binding
PF547_00870	COG3328	transposase activity
PF547_00895	COG2205	protein histidine kinase activity
PF547_00895	COG2198	Histidine kinase
PF547_00895	COG0784	Response regulator, receiver
PF547_00900	COG3162	membrane
PF547_00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF547_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF547_00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PF547_00940	COG1309	transcriptional regulator
PF547_00960	COG0352	thiamine-phosphate diphosphorylase activity
PF547_00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF547_00960	COG0351	phosphomethylpyrimidine kinase
PF547_00970	COG2814	Major facilitator Superfamily
PF547_00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF547_00995	COG1113	amino acid transport
PF547_01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF547_01010	COG1012	belongs to the aldehyde dehydrogenase family
PF547_01020	COG1335	isochorismatase
PF547_01050	COG2814	Major facilitator Superfamily
PF547_01055	COG0583	DNA-binding transcription factor activity
PF547_01120	COG1733	regulation of RNA biosynthetic process
PF547_01125	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF547_01190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF547_01205	COG2329	Antibiotic biosynthesis monooxygenase
PF547_01235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PF547_01265	COG0427	acetyl-CoA hydrolase
PF547_01290	COG0659	secondary active sulfate transmembrane transporter activity
PF547_01295	COG4221	oxidoreductase activity
PF547_01300	COG2873	o-acetylhomoserine
PF547_01305	COG0488	(ABC) transporter
PF547_01390	COG0833	amino acid
PF547_01435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PF547_01440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PF547_01455	COG2226	methyltransferase
PF547_01505	COG0070	glutamate synthase
PF547_01505	COG0069	glutamate synthase activity
PF547_01505	COG0067	glutamate synthase
PF547_01510	COG0493	'glutamate synthase
PF547_01520	COG1704	LemA family
PF547_01525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PF547_01545	COG3307	-O-antigen
PF547_01565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF547_01580	COG0194	GDP metabolic process
PF547_01630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PF547_01650	COG5380	lipid catabolic process
PF547_01655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PF547_01680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF547_01685	COG0277	FAD linked oxidase domain protein
PF547_01695	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF547_01700	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF547_01715	COG1289	transmembrane transporter activity
PF547_01725	COG0628	permease
PF547_01730	COG1192	Involved in chromosome partitioning
PF547_01760	COG0833	amino acid
PF547_01765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF547_01770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF547_01780	COG1012	belongs to the aldehyde dehydrogenase family
PF547_01820	COG0583	DNA-binding transcription factor activity
PF547_01865	COG0517	IMP dehydrogenase activity
PF547_01870	COG1983	PspC domain protein
PF547_01880	COG1960	acyl-CoA dehydrogenase activity
PF547_01895	COG0408	coproporphyrinogen oxidase activity
PF547_01915	COG0513	Belongs to the DEAD box helicase family
PF547_01925	COG1127	ABC transporter
PF547_01930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PF547_01940	COG2854	intermembrane phospholipid transfer
PF547_01950	COG0598	Magnesium transport protein CorA
PF547_01960	COG0494	nUDIX hydrolase
PF547_01965	COG1040	competence protein
PF547_01970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PF547_01990	COG1946	Acyl-CoA thioesterase
PF547_01995	COG1301	dicarboxylic acid transport
PF547_02010	COG1959	2 iron, 2 sulfur cluster binding
PF547_02015	COG1017	nitric oxide dioxygenase activity
PF547_02015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF547_02020	COG0433	COG0433 Predicted ATPase
PF547_02025	COG0626	cystathionine gamma-synthase activity
PF547_02180	COG1960	acyl-CoA dehydrogenase activity
PF547_02185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PF547_02215	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PF547_02220	COG0339	signal peptide processing
PF547_02225	COG0557	exoribonuclease II activity
PF547_02270	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF547_02275	COG2169	Transcriptional regulator
PF547_02280	COG0697	spore germination
PF547_02285	COG1295	ribonuclease BN
PF547_02320	COG1702	phosphate starvation-inducible protein PhoH
PF547_02330	COG0739	heme binding
PF547_02330	COG0741	lytic transglycosylase activity
PF547_02330	COG1196	nuclear chromosome segregation
PF547_02360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PF547_02365	COG1183	phosphatidylcholine synthase activity
PF547_02410	COG1960	acyl-CoA dehydrogenase activity
PF547_02415	COG1309	transcriptional regulator
PF547_02430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF547_02435	COG1960	acyl-CoA dehydrogenase activity
PF547_02455	COG2969	positive regulation of protein catabolic process
PF547_02465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PF547_02480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PF547_02485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PF547_02505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PF547_02515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF547_02520	COG1408	metallophosphoesterase
PF547_02530	COG2199	diguanylate cyclase activity
PF547_02590	COG1607	acyl-coa hydrolase
PF547_02620	COG2350	Protein conserved in bacteria
PF547_02630	COG0613	PHP domain protein
PF547_02635	COG3781	membrane
PF547_02645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PF547_02650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF547_02660	COG1862	Preprotein translocase
PF547_02690	COG2205	protein histidine kinase activity
PF547_02695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PF547_02715	COG0726	polysaccharide deacetylase
PF547_02720	COG0463	Glycosyl transferase, family 2
PF547_02725	COG0438	transferase activity, transferring glycosyl groups
PF547_02790	COG0625	glutathione transferase activity
PF547_02795	COG0583	DNA-binding transcription factor activity
PF547_02800	COG1960	acyl-CoA dehydrogenase activity
PF547_02805	COG1960	acyl-CoA dehydrogenase activity
PF547_02815	COG2205	protein histidine kinase activity
PF547_02820	COG0745	RESPONSE REGULATOR receiver
PF547_02825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PF547_02845	COG2096	Adenosyltransferase
PF547_02895	COG0285	dihydrofolate synthase activity
PF547_02915	COG0450	alkyl hydroperoxide reductase
PF547_02930	COG0477	Major facilitator Superfamily
PF547_02935	COG1272	protein, Hemolysin III
PF547_02970	COG2207	Transcriptional regulator
PF547_02990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF547_03010	COG0183	Belongs to the thiolase family
PF547_03020	COG2885	chlorophyll binding
PF547_03020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PF547_03030	COG1690	Belongs to the RtcB family
PF547_03035	COG0833	amino acid
PF547_03045	COG2233	PERMEase
PF547_03050	COG1217	gtp-binding protein TYPA
PF547_03075	COG2094	Belongs to the DNA glycosylase MPG family
PF547_03120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PF547_03165	COG1061	Type III restriction enzyme res subunit
PF547_03170	COG1002	Type II restriction enzyme, methylase subunits
PF547_03180	COG0659	secondary active sulfate transmembrane transporter activity
PF547_03185	COG0589	response to stress
PF547_03215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF547_03235	COG1902	pentaerythritol trinitrate reductase activity
PF547_03250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF547_03255	COG0354	folic acid binding
PF547_03265	COG3189	MarR family transcriptional regulator
PF547_03270	COG2824	Alkylphosphonate utilization operon protein PhnA
PF547_03275	COG3422	double-strand break repair
PF547_03315	COG0840	transmembrane signaling receptor activity
PF547_03335	COG5510	response to toxic substance
PF547_03345	COG2832	Protein of unknown function (DUF454)
PF547_03350	COG1376	ErfK ybiS ycfS ynhG family protein
PF547_03390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF547_03400	COG1289	transmembrane transporter activity
PF547_03405	COG2814	Major facilitator Superfamily
PF547_03425	COG1115	amino acid carrier protein
PF547_03430	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF547_03435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF547_03440	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
PF547_03490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF547_03500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF547_03505	COG1077	Cell shape determining protein MreB Mrl
PF547_03510	COG1792	Involved in formation and maintenance of cell shape
PF547_03515	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PF547_03520	COG0424	maF-like protein
PF547_03525	COG1530	ribonuclease E activity
PF547_03535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF547_03545	COG0560	Phosphoserine phosphatase
PF547_03555	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF547_03580	COG2207	Transcriptional regulator
PF547_03600	COG1113	amino acid transport
PF547_03605	COG2828	Protein conserved in bacteria
PF547_03610	COG0142	geranyltranstransferase activity
PF547_03615	COG2315	Protein conserved in bacteria
PF547_03630	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF547_03650	COG2194	sulfuric ester hydrolase activity
PF547_03655	COG0745	RESPONSE REGULATOR receiver
PF547_03660	COG0642	Histidine kinase
PF547_03670	COG0004	ammonium transporteR
PF547_03675	COG0583	DNA-binding transcription factor activity
PF547_03695	COG0525	valine-tRNA ligase activity
PF547_03705	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_03715	COG0393	Putative heavy-metal-binding
PF547_03720	COG0393	Putative heavy-metal-binding
PF547_03725	COG1538	Outer membrane efflux protein
PF547_03735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF547_03740	COG0671	phosphoesterase, PA-phosphatase related
PF547_03770	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PF547_03785	COG1648	precorrin-2 dehydrogenase activity
PF547_03785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF547_03790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PF547_03795	COG1733	regulation of RNA biosynthetic process
PF547_03805	COG0531	amino acid
PF547_03820	COG0321	lipoyl(octanoyl) transferase activity
PF547_03825	COG2921	Belongs to the UPF0250 family
PF547_03865	COG2009	succinate dehydrogenase
PF547_03870	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PF547_03875	COG1053	succinate dehydrogenase
PF547_03880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PF547_03905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF547_03925	COG2354	Protein conserved in bacteria
PF547_03930	COG2321	neutral zinc metallopeptidase
PF547_03950	COG2843	Capsule synthesis protein
PF547_03965	COG0589	response to stress
PF547_03985	COG0505	Belongs to the CarA family
PF547_04010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF547_04015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PF547_04065	COG0477	Major facilitator Superfamily
PF547_04070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PF547_04085	COG1597	lipid kinase activity
PF547_04090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF547_04120	COG0584	glycerophosphoryl diester phosphodiesterase
PF547_04140	COG0741	lytic transglycosylase activity
PF547_04160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PF547_04175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF547_04205	COG0778	Nitroreductase
PF547_04220	COG1929	Belongs to the glycerate kinase type-1 family
PF547_04225	COG0243	molybdopterin cofactor binding
PF547_04230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PF547_04235	COG3339	Conserved Protein
PF547_04245	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PF547_04260	COG1113	amino acid transport
PF547_04270	COG0019	diaminopimelate decarboxylase activity
PF547_04280	COG1280	lysine exporter protein (LysE YggA)
PF547_04285	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PF547_04315	COG0463	Glycosyl transferase, family 2
PF547_04335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF547_04370	COG4591	ABC-type transport system involved in lipoprotein release permease component
PF547_04375	COG1136	(ABC) transporter
PF547_04380	COG0658	competence protein
PF547_04380	COG2333	competence protein COMEC
PF547_04390	COG0616	signal peptide processing
PF547_04390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PF547_04395	COG0596	Alpha beta hydrolase
PF547_04400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PF547_04410	COG0628	permease
PF547_04445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF547_04465	COG0823	Involved in the tonB-independent uptake of proteins
PF547_04485	COG0824	Thioesterase
PF547_04490	COG1473	amidohydrolase
PF547_04510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PF547_04510	COG0047	phosphoribosylformylglycinamidine synthase activity
PF547_04515	COG2814	Major facilitator Superfamily
PF547_04530	COG1024	Enoyl-CoA hydratase
PF547_04535	COG1056	cytidyltransferase-related domain
PF547_04535	COG1051	belongs to the nudix hydrolase family
PF547_04545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PF547_04560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PF547_04580	COG0583	DNA-binding transcription factor activity
PF547_04585	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PF547_04590	COG4208	sulfate ABC transporter
PF547_04595	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PF547_04605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PF547_04610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF547_04615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF547_04635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF547_04650	COG0681	Belongs to the peptidase S26 family
PF547_04665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PF547_04675	COG1381	Involved in DNA repair and RecF pathway recombination
PF547_04680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PF547_04690	COG4221	oxidoreductase activity
PF547_04740	COG0556	nucleotide-excision repair
PF547_04795	COG2070	2-Nitropropane dioxygenase
PF547_04825	COG1215	transferase activity, transferring glycosyl groups
PF547_04840	COG0415	Belongs to the DNA photolyase family
PF547_04850	COG1252	NADH dehydrogenase
PF547_04855	COG1686	Belongs to the peptidase S11 family
PF547_04870	COG1187	pseudouridine synthase activity
PF547_04895	COG0477	Major facilitator Superfamily
PF547_04900	COG0583	DNA-binding transcription factor activity
PF547_04905	COG1823	symporter activity
PF547_04915	COG0612	Peptidase, M16
PF547_04940	COG0352	thiamine-phosphate diphosphorylase activity
PF547_04975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF547_04990	COG1309	transcriptional regulator
PF547_05000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF547_05005	COG0076	glutamate decarboxylase activity
PF547_05015	COG1522	sequence-specific DNA binding
PF547_05020	COG3961	Belongs to the TPP enzyme family
PF547_05025	COG1113	amino acid transport
PF547_05030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PF547_05035	COG0573	inorganic phosphate transmembrane transporter activity
PF547_05045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF547_05050	COG0616	signal peptide processing
PF547_05060	COG3328	transposase activity
PF547_05090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PF547_05095	COG1686	Belongs to the peptidase S11 family
PF547_05120	COG0583	DNA-binding transcription factor activity
PF547_05125	COG1067	ATP-dependent peptidase activity
PF547_05170	COG1966	Carbon starvation protein
PF547_05175	COG2879	small protein
PF547_05210	COG2508	Transcriptional regulator
PF547_05210	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
PF547_05230	COG1113	amino acid transport
PF547_05235	COG0583	DNA-binding transcription factor activity
PF547_05240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF547_05245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF547_05255	COG1012	belongs to the aldehyde dehydrogenase family
PF547_05265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF547_05270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF547_05270	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PF547_05305	COG2814	Major facilitator Superfamily
PF547_05310	COG4948	Mandelate Racemase Muconate Lactonizing
PF547_05320	COG1309	transcriptional regulator
PF547_05340	COG1741	Belongs to the pirin family
PF547_05350	COG2964	Protein conserved in bacteria
PF547_05365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF547_05375	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF547_05380	COG4605	iron ion homeostasis
PF547_05385	COG4604	ABC transporter, ATP-binding protein
PF547_05390	COG4607	ABC-type enterochelin transport system periplasmic component
PF547_05395	COG4774	siderophore transport
PF547_05405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF547_05410	COG1021	2,3-dihydroxybenzoate-AMP ligase
PF547_05415	COG1535	isochorismatase
PF547_05415	COG3433	isochorismatase activity
PF547_05430	COG1132	(ABC) transporter
PF547_05435	COG1132	(ABC) transporter
PF547_05440	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
PF547_05450	COG1169	isochorismate synthase
PF547_05465	COG3739	integral membrane protein
PF547_05490	COG0302	gtp cyclohydrolase
PF547_05500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PF547_05530	COG0308	aminopeptidase N
PF547_05535	COG0512	Glutamine amidotransferase of anthranilate synthase
PF547_05720	COG5410	chromosome segregation
PF547_05855	COG0739	heme binding
PF547_05900	COG0582	viral genome integration into host DNA
PF547_05915	COG0174	glutamine synthetase
PF547_05925	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PF547_05960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF547_05965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PF547_05970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF547_05990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF547_05995	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PF547_06000	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PF547_06015	COG1960	acyl-CoA dehydrogenase activity
PF547_06020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF547_06025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF547_06035	COG2223	nitrite transmembrane transporter activity
PF547_06045	COG0024	Methionine aminopeptidase
PF547_06050	COG0052	Belongs to the universal ribosomal protein uS2 family
PF547_06065	COG2207	Transcriptional regulator
PF547_06090	COG2951	lytic endotransglycosylase activity
PF547_06095	COG0772	Belongs to the SEDS family
PF547_06110	COG0842	Transport permease protein
PF547_06115	COG1131	(ABC) transporter
PF547_06160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF547_06175	COG4215	(ABC) transporter
PF547_06180	COG4160	amino acid transport
PF547_06185	COG4598	ABC transporter
PF547_06195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF547_06200	COG0826	peptidase U32
PF547_06205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF547_06220	COG1720	tRNA m6t6A37 methyltransferase activity
PF547_06230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PF547_06245	COG0642	Histidine kinase
PF547_06255	COG0494	nUDIX hydrolase
PF547_06265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF547_06270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF547_06275	COG3139	Protein of unknown function (DUF1315)
PF547_06280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PF547_06285	COG1301	dicarboxylic acid transport
PF547_06290	COG1960	acyl-CoA dehydrogenase activity
PF547_06295	COG2819	hydrolase of the alpha beta superfamily
PF547_06305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PF547_06315	COG2195	Cleaves the N-terminal amino acid of tripeptides
PF547_06320	COG1234	tRNA 3'-trailer cleavage
PF547_06350	COG2363	Small membrane protein
PF547_06375	COG0513	Belongs to the DEAD box helicase family
PF547_06385	COG0778	Nitroreductase
PF547_06415	COG1286	toxin biosynthetic process
PF547_06440	COG4783	chaperone-mediated protein folding
PF547_06445	COG1610	YqeY-like protein
PF547_06550	COG3111	PFAM Bacterial OB fold (BOF) protein
PF547_06575	COG3243	poly(R)-hydroxyalkanoic acid synthase
PF547_06580	COG0786	glutamate:sodium symporter activity
PF547_06590	COG2186	Transcriptional regulator
PF547_06640	COG0477	Major facilitator Superfamily
PF547_06670	COG2985	domain, Protein
PF547_06680	COG2995	paraquat-inducible protein a
PF547_06685	COG3008	intermembrane lipid transfer
PF547_06685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PF547_06715	COG0488	(ABC) transporter
PF547_06720	COG3173	Aminoglycoside phosphotransferase
PF547_06730	COG2433	Pfam Transposase IS66
PF547_06770	COG1301	dicarboxylic acid transport
PF547_06780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF547_06785	COG2011	ABC-type metal ion transport system permease component
PF547_06790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF547_06795	COG1464	Belongs to the NlpA lipoprotein family
PF547_06800	COG0151	Belongs to the GarS family
PF547_06805	COG0138	bifunctional purine biosynthesis protein purh
PF547_06810	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PF547_06840	COG2308	Evidence 4 Homologs of previously reported genes of
PF547_06850	COG1305	Transglutaminase-like
PF547_06860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF547_06865	COG0305	Participates in initiation and elongation during chromosome replication
PF547_06890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PF547_06900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF547_06905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF547_06930	COG0726	polysaccharide deacetylase
PF547_06930	COG1649	PFAM Uncharacterised BCR, COG1649
PF547_06935	COG1215	transferase activity, transferring glycosyl groups
PF547_06940	COG3658	cytochrome
PF547_06950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF547_06965	COG0583	DNA-binding transcription factor activity
PF547_06985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF547_07005	COG1960	acyl-CoA dehydrogenase activity
PF547_07010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF547_07015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF547_07040	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PF547_07045	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
PF547_07055	COG2205	protein histidine kinase activity
PF547_07060	COG0745	RESPONSE REGULATOR receiver
PF547_07065	COG0174	glutamine synthetase
PF547_07085	COG0729	surface antigen
PF547_07110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF547_07115	COG2814	Major facilitator Superfamily
PF547_07135	COG0583	DNA-binding transcription factor activity
PF547_07150	COG1187	pseudouridine synthase activity
PF547_07170	COG0802	atpase or kinase
PF547_07185	COG1923	regulation of RNA biosynthetic process
PF547_07190	COG0697	spore germination
PF547_07205	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF547_07215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF547_07220	COG0519	Catalyzes the synthesis of GMP from XMP
PF547_07220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF547_07225	COG4302	ethanolamine ammonia-lyase activity
PF547_07230	COG4303	Ethanolamine ammonia lyase large subunit
PF547_07235	COG0531	amino acid
PF547_07255	COG1454	alcohol dehydrogenase
PF547_07260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF547_07270	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
PF547_07290	COG0308	aminopeptidase N
PF547_07320	COG1605	Chorismate mutase
PF547_07340	COG1309	transcriptional regulator
PF547_07350	COG0668	transmembrane transport
PF547_07385	COG4773	Receptor
PF547_07405	COG0488	(ABC) transporter
PF547_07410	COG0589	response to stress
PF547_07435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PF547_07445	COG3135	benzoate transporter
PF547_07450	COG1522	sequence-specific DNA binding
PF547_07460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PF547_07465	COG0583	DNA-binding transcription factor activity
PF547_07475	COG0183	Belongs to the thiolase family
PF547_07485	COG2030	dehydratase
PF547_07490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF547_07505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PF547_07515	COG0824	Thioesterase
PF547_07520	COG1454	alcohol dehydrogenase
PF547_07530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF547_07550	COG0069	glutamate synthase activity
PF547_07715	COG5410	chromosome segregation
PF547_07835	COG0739	heme binding
PF547_07880	COG2194	sulfuric ester hydrolase activity
PF547_07920	COG0006	proline dipeptidase activity
PF547_07925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF547_07930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF547_07950	COG1279	arginine transmembrane transporter activity
PF547_07955	COG0583	DNA-binding transcription factor activity
PF547_07995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF547_08000	COG0741	lytic transglycosylase activity
PF547_08000	COG1388	LysM domain
PF547_08000	COG0741	lytic transglycosylase activity
PF547_08000	COG1388	LysM domain
PF547_08010	COG4174	ABC transporter (Permease)
PF547_08015	COG4239	(ABC) transporter, permease
PF547_08020	COG4172	Belongs to the ABC transporter superfamily
PF547_08040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF547_08050	COG2203	Gaf domain
PF547_08050	COG5001	Diguanylate cyclase
PF547_08050	COG3706	GGDEF domain
PF547_08050	COG4251	negative regulation of phosphorylation
PF547_08060	COG1902	pentaerythritol trinitrate reductase activity
PF547_08060	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF547_08100	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PF547_08110	COG1309	transcriptional regulator
PF547_08115	COG1741	Belongs to the pirin family
PF547_08130	COG2072	flavoprotein involved in K transport
PF547_08140	COG2252	PERMEase
PF547_08145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PF547_08150	COG3038	cytochrome b561
PF547_08160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PF547_08170	COG0527	aspartate kinase activity
PF547_08180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF547_08190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PF547_08205	COG0667	Aldo Keto reductase
PF547_08225	COG1765	OsmC-like protein
PF547_08240	COG0542	response to heat
PF547_08275	COG2885	chlorophyll binding
PF547_08285	COG0625	glutathione transferase activity
PF547_08290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PF547_08310	COG3634	alkyl hydroperoxide reductase activity
PF547_08320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PF547_08330	COG0450	alkyl hydroperoxide reductase
PF547_08335	COG1643	Atp-dependent helicase
PF547_08350	COG2814	Major facilitator Superfamily
PF547_08355	COG3135	benzoate transporter
PF547_08360	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_08365	COG0543	2 iron, 2 sulfur cluster binding
PF547_08365	COG0633	Ferredoxin
PF547_08370	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
PF547_08375	COG4638	Rieske (2fe-2S)
PF547_08385	COG0583	DNA-binding transcription factor activity
PF547_08435	COG1570	exodeoxyribonuclease VII activity
PF547_08470	COG1280	lysine exporter protein (LysE YggA)
PF547_08475	COG1278	Cold shock
PF547_08510	COG2814	Major facilitator Superfamily
PF547_08545	COG0517	IMP dehydrogenase activity
PF547_08545	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PF547_08550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PF547_08560	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PF547_08565	COG1137	ATPase activity
PF547_08570	COG1538	Outer membrane efflux protein
PF547_08600	COG4122	O-methyltransferase activity
PF547_08610	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PF547_08625	COG1522	sequence-specific DNA binding
PF547_08630	COG5006	permease, DMT superfamily
PF547_08640	COG1560	Kdo2-lipid A biosynthetic process
PF547_08655	COG2814	Major facilitator Superfamily
PF547_08675	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF547_08725	COG0583	DNA-binding transcription factor activity
PF547_08730	COG1914	H( )-stimulated, divalent metal cation uptake system
PF547_08750	COG4770	biotin carboxylase activity
PF547_08755	COG0038	chloride channel
PF547_08775	COG1309	transcriptional regulator
PF547_08785	COG1063	alcohol dehydrogenase
PF547_08800	COG0439	Biotin carboxylase
PF547_08805	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF547_08825	COG0864	Transcriptional regulator
PF547_08835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF547_08840	COG1116	anion transmembrane transporter activity
PF547_08955	COG0590	tRNA wobble adenosine to inosine editing
PF547_08960	COG2807	transmembrane transport
PF547_08975	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PF547_08990	COG0789	Transcriptional regulator
PF547_09000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF547_09020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF547_09030	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF547_09045	COG1012	belongs to the aldehyde dehydrogenase family
PF547_09050	COG0531	amino acid
PF547_09055	COG1760	l-serine dehydratase
PF547_09060	COG1012	belongs to the aldehyde dehydrogenase family
PF547_09060	COG2030	dehydratase
PF547_09065	COG3396	Phenylacetate-CoA oxygenase
PF547_09070	COG3460	Phenylacetate-CoA oxygenase
PF547_09075	COG3396	Phenylacetate-CoA oxygenase
PF547_09080	COG2151	metal-sulfur cluster biosynthetic enzyme
PF547_09085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF547_09090	COG1024	Enoyl-CoA hydratase
PF547_09095	COG1024	Enoyl-CoA hydratase
PF547_09100	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF547_09105	COG0183	Belongs to the thiolase family
PF547_09110	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PF547_09115	COG3327	negative regulation of DNA-templated transcription, initiation
PF547_09125	COG2050	protein possibly involved in aromatic compounds catabolism
PF547_09160	COG0753	catalase activity
PF547_09165	COG3038	cytochrome b561
PF547_09185	COG2267	carboxylic ester hydrolase activity
PF547_09190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF547_09195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF547_09200	COG1012	belongs to the aldehyde dehydrogenase family
PF547_09210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF547_09220	COG1012	belongs to the aldehyde dehydrogenase family
PF547_09225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF547_09230	COG0583	DNA-binding transcription factor activity
PF547_09240	COG1414	Transcriptional regulator
PF547_09245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF547_09255	COG1840	ABC-type Fe3 transport system, periplasmic component
PF547_09260	COG3842	ATPase activity
PF547_09275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PF547_09280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF547_09285	COG2814	Major facilitator Superfamily
PF547_09290	COG1960	acyl-CoA dehydrogenase activity
PF547_09305	COG1024	Enoyl-CoA hydratase
PF547_09315	COG2814	Major facilitator Superfamily
PF547_09325	COG0183	Belongs to the thiolase family
PF547_09330	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF547_09335	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_09340	COG1024	Enoyl-CoA hydratase
PF547_09345	COG1960	acyl-CoA dehydrogenase activity
PF547_09350	COG2814	Major facilitator Superfamily
PF547_09355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF547_09360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF547_09370	COG2814	Major facilitator Superfamily
PF547_09380	COG1960	acyl-CoA dehydrogenase activity
PF547_09395	COG0583	DNA-binding transcription factor activity
PF547_09405	COG4770	biotin carboxylase activity
PF547_09410	COG1024	Enoyl-CoA hydratase
PF547_09415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF547_09420	COG1960	acyl-CoA dehydrogenase activity
PF547_09425	COG1309	transcriptional regulator
PF547_09430	COG0318	PFAM AMP-dependent synthetase and ligase
PF547_09450	COG0583	DNA-binding transcription factor activity
PF547_09500	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_09520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PF547_09540	COG0784	Response regulator, receiver
PF547_09540	COG2205	protein histidine kinase activity
PF547_09560	COG0765	amino acid transport
PF547_09565	COG0765	amino acid transport
PF547_09570	COG1126	abc transporter atp-binding protein
PF547_09575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF547_09580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF547_09595	COG1280	lysine exporter protein (LysE YggA)
PF547_09605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF547_09610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF547_09615	COG1045	serine acetyltransferase
PF547_09630	COG0583	DNA-binding transcription factor activity
PF547_09635	COG0625	glutathione transferase activity
PF547_09640	COG0625	glutathione transferase activity
PF547_09645	COG0583	DNA-binding transcription factor activity
PF547_09655	COG1346	cytolysis
PF547_09675	COG2814	Major facilitator Superfamily
PF547_09685	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
PF547_09690	COG3052	prosthetic group binding
PF547_09710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF547_09730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF547_09740	COG1294	oxidase, subunit
PF547_09745	COG1271	oxidase subunit
PF547_09770	COG0477	Major facilitator Superfamily
PF547_09780	COG4521	taurine ABC transporter
PF547_09785	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PF547_09790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF547_09795	COG2175	clavaminate synthase activity
PF547_09805	COG1953	Uracil, thiamine, allantoin
PF547_09815	COG0583	DNA-binding transcription factor activity
PF547_09825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PF547_09840	COG0640	Transcriptional regulator
PF547_09845	COG0798	PFAM Bile acid sodium symporter
PF547_09850	COG0583	DNA-binding transcription factor activity
PF547_09865	COG3634	alkyl hydroperoxide reductase activity
PF547_09905	COG0436	Aminotransferase
PF547_09915	COG0386	Belongs to the glutathione peroxidase family
PF547_09955	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF547_09980	COG0012	GTP binding
PF547_09985	COG2011	ABC-type metal ion transport system permease component
PF547_09990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF547_10000	COG1464	Belongs to the NlpA lipoprotein family
PF547_10030	COG0765	amino acid transport
PF547_10035	COG0765	amino acid transport
PF547_10040	COG1126	abc transporter atp-binding protein
PF547_10050	COG1522	sequence-specific DNA binding
PF547_10065	COG1309	transcriptional regulator
PF547_10085	COG0583	DNA-binding transcription factor activity
PF547_10095	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF547_10105	COG0697	spore germination
PF547_10130	COG3121	Chaperone
PF547_10135	COG3539	Fimbrial protein
PF547_10160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PF547_10160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PF547_10205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PF547_10215	COG2353	YceI-like domain
PF547_10225	COG3698	Phosphodiester glycosidase
PF547_10240	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PF547_10245	COG0506	proline dehydrogenase activity
PF547_10245	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PF547_10245	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PF547_10255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF547_10260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PF547_10280	COG1132	(ABC) transporter
PF547_10285	COG3122	Protein conserved in bacteria
PF547_10290	COG3619	membrane
PF547_10305	COG0640	Transcriptional regulator
PF547_10315	COG2850	peptidyl-arginine hydroxylation
PF547_10320	COG0424	maF-like protein
PF547_10340	COG0191	fructose-bisphosphate aldolase activity
PF547_10345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF547_10360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PF547_10370	COG1192	Involved in chromosome partitioning
PF547_10375	COG1475	DNA binding
PF547_10380	COG0811	peptide transport
PF547_10390	COG1132	(ABC) transporter
PF547_10395	COG1663	tetraacyldisaccharide 4'-kinase activity
PF547_10415	COG0084	hydrolase, TatD family'
PF547_10480	COG0776	regulation of translation
PF547_10510	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PF547_10515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PF547_10565	COG0339	signal peptide processing
PF547_10575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF547_10610	COG0702	epimerase
PF547_10615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PF547_10635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PF547_10665	COG0316	Belongs to the HesB IscA family
PF547_10670	COG0822	iron-sulfur transferase activity
PF547_10695	COG0776	regulation of translation
PF547_10700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF547_10705	COG2207	Transcriptional regulator
PF547_10710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF547_10715	COG1960	acyl-CoA dehydrogenase activity
PF547_10720	COG1960	acyl-CoA dehydrogenase activity
PF547_10735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PF547_10755	COG4264	IucA IucC family
PF547_10760	COG4264	IucA IucC family
PF547_10800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF547_10815	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PF547_10835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PF547_10840	COG0730	response to heat
PF547_10865	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF547_10880	COG1131	(ABC) transporter
PF547_10885	COG0842	Transport permease protein
PF547_10890	COG0842	Transport permease protein
PF547_10945	COG2226	methyltransferase
PF547_10970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PF547_11005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF547_11015	COG0133	tryptophan synthase activity
PF547_11030	COG3706	GGDEF domain
PF547_11045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF547_11050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF547_11055	COG0022	dehydrogenase e1 component
PF547_11060	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF547_11065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF547_11075	COG1063	alcohol dehydrogenase
PF547_11080	COG3781	membrane
PF547_11090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF547_11090	COG3453	Protein conserved in bacteria
PF547_11110	COG0730	response to heat
PF547_11125	COG3708	Transcriptional regulator
PF547_11125	COG2207	Transcriptional regulator
PF547_11130	COG1733	regulation of RNA biosynthetic process
PF547_11135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF547_11145	COG2188	Transcriptional regulator
PF547_11160	COG4521	taurine ABC transporter
PF547_11165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF547_11185	COG0477	Major facilitator Superfamily
PF547_11195	COG1027	Aspartate ammonia-lyase
PF547_11210	COG0583	DNA-binding transcription factor activity
PF547_11215	COG0583	DNA-binding transcription factor activity
PF547_11220	COG0183	Belongs to the thiolase family
PF547_11225	COG2031	fatty acid transporter
PF547_11230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF547_11240	COG0583	DNA-binding transcription factor activity
PF547_11250	COG2610	gluconate transmembrane transporter activity
PF547_11255	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_11265	COG2207	Transcriptional regulator
PF547_11280	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_11295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF547_11295	COG0543	2 iron, 2 sulfur cluster binding
PF547_11300	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
PF547_11305	COG4638	Rieske (2fe-2S)
PF547_11315	COG0725	ABC transporter, periplasmic molybdate-binding protein
PF547_11320	COG4149	molybdate abc transporter
PF547_11325	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PF547_11330	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_11400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF547_11415	COG0753	catalase activity
PF547_11425	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PF547_11455	COG3539	Fimbrial protein
PF547_11475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF547_11495	COG2072	flavoprotein involved in K transport
PF547_11505	COG1538	Outer membrane efflux protein
PF547_11510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF547_11515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF547_11520	COG0745	RESPONSE REGULATOR receiver
PF547_11525	COG2205	protein histidine kinase activity
PF547_11535	COG2207	Transcriptional regulator
PF547_11550	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_11600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PF547_11725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF547_11745	COG1120	ATPase activity
PF547_11750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF547_11760	COG1064	alcohol dehydrogenase
PF547_11775	COG2207	Transcriptional regulator
PF547_11780	COG2084	Dehydrogenase
PF547_11790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF547_11795	COG0583	DNA-binding transcription factor activity
PF547_11805	COG0129	dihydroxy-acid dehydratase activity
PF547_11810	COG1012	belongs to the aldehyde dehydrogenase family
PF547_11825	COG1566	PFAM secretion protein HlyD family protein
PF547_11860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PF547_11890	COG0583	DNA-binding transcription factor activity
PF547_11905	COG2188	Transcriptional regulator
PF547_11935	COG3210	domain, Protein
PF547_11940	COG2831	hemolysin activation secretion protein
PF547_11950	COG1473	amidohydrolase
PF547_11960	COG0475	glutathione-regulated potassium exporter activity
PF547_11960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF547_11970	COG0583	DNA-binding transcription factor activity
PF547_11975	COG1335	isochorismatase
PF547_11985	COG1309	transcriptional regulator
PF547_12015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF547_12025	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF547_12025	COG1902	pentaerythritol trinitrate reductase activity
PF547_12030	COG1846	Transcriptional regulator
PF547_12050	COG0753	catalase activity
PF547_12065	COG1012	belongs to the aldehyde dehydrogenase family
PF547_12080	COG3162	membrane
PF547_12090	COG3829	transcription factor binding
PF547_12095	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_12100	COG1960	acyl-CoA dehydrogenase activity
PF547_12120	COG1012	belongs to the aldehyde dehydrogenase family
PF547_12140	COG2186	Transcriptional regulator
PF547_12150	COG0583	DNA-binding transcription factor activity
PF547_12155	COG4948	Mandelate Racemase Muconate Lactonizing
PF547_12160	COG4829	muconolactone delta-isomerase
PF547_12170	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF547_12175	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF547_12180	COG0183	Belongs to the thiolase family
PF547_12185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF547_12195	COG1012	belongs to the aldehyde dehydrogenase family
PF547_12205	COG3733	amine oxidase
PF547_12215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF547_12225	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_12235	COG4638	Rieske (2fe-2S)
PF547_12255	COG0154	amidase activity
PF547_12265	COG2814	Major facilitator Superfamily
PF547_12290	COG1960	acyl-CoA dehydrogenase activity
PF547_12295	COG0583	DNA-binding transcription factor activity
PF547_12300	COG1414	Transcriptional regulator
PF547_12315	COG2391	methyltransferase activity
PF547_12325	COG4993	Dehydrogenase
PF547_12330	COG3659	wide pore channel activity
PF547_12335	COG3420	alginic acid biosynthetic process
PF547_12340	COG0710	3-dehydroquinate dehydratase activity
PF547_12345	COG3485	protocatechuate 3,4-dioxygenase
PF547_12350	COG3485	protocatechuate 3,4-dioxygenase
PF547_12355	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF547_12360	COG2271	Major facilitator Superfamily
PF547_12365	COG0596	Alpha beta hydrolase
PF547_12370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PF547_12375	COG0183	Belongs to the thiolase family
PF547_12380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF547_12385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF547_12395	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PF547_12400	COG2323	membrane
PF547_12445	COG1902	pentaerythritol trinitrate reductase activity
PF547_12445	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF547_12470	COG0542	response to heat
PF547_12475	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PF547_12505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF547_12510	COG0569	domain protein
PF547_12515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PF547_12530	COG4774	siderophore transport
PF547_12535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF547_12545	COG1585	Membrane protein implicated in regulation of membrane protease activity
PF547_12560	COG1294	oxidase, subunit
PF547_12565	COG4890	Cyd operon protein YbgT
PF547_12580	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
PF547_12590	COG0552	protein localization to endoplasmic reticulum
PF547_12615	COG0516	GMP reductase activity
PF547_12615	COG0517	IMP dehydrogenase activity
PF547_12620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF547_12625	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PF547_12635	COG0583	DNA-binding transcription factor activity
PF547_12640	COG0024	Methionine aminopeptidase
PF547_12670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PF547_12670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF547_12675	COG1105	Belongs to the carbohydrate kinase PfkB family
PF547_12680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF547_12680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF547_12680	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PF547_12700	COG3300	MHYT domain
PF547_12700	COG5001	Diguanylate cyclase
PF547_12715	COG2135	peptidase activity
PF547_12720	COG0659	secondary active sulfate transmembrane transporter activity
PF547_12740	COG1113	amino acid transport
PF547_12750	COG1522	sequence-specific DNA binding
PF547_12775	COG1011	Hydrolase
PF547_12780	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PF547_12790	COG2137	regulation of response to DNA damage stimulus
PF547_12805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF547_12840	COG0575	Belongs to the CDS family
PF547_12845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PF547_12865	COG3852	Histidine kinase
PF547_12870	COG2204	response regulator
PF547_12925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF547_12930	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PF547_12950	COG0697	spore germination
PF547_12955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF547_12965	COG0303	'Molybdopterin
PF547_12970	COG0315	cyclic pyranopterin monophosphate synthase activity
PF547_12970	COG0521	Mo-molybdopterin cofactor biosynthetic process
PF547_12985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PF547_12990	COG0243	molybdopterin cofactor binding
PF547_13000	COG0243	molybdopterin cofactor binding
PF547_13005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF547_13010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF547_13010	COG2146	nitrite reductase [NAD(P)H] activity
PF547_13020	COG0745	RESPONSE REGULATOR receiver
PF547_13025	COG1116	anion transmembrane transporter activity
PF547_13025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF547_13045	COG0511	ligase activity, forming carbon-carbon bonds
PF547_13060	COG2814	Major facilitator Superfamily
PF547_13125	COG0739	heme binding
PF547_13455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PF547_13480	COG3384	dioxygenase
PF547_13490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF547_13495	COG2878	Part of a membrane complex involved in electron transport
PF547_13500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PF547_13525	COG0768	penicillin binding
PF547_13530	COG0742	ribosomal rna small subunit methyltransferase
PF547_13545	COG0830	nickel cation binding
PF547_13595	COG1253	flavin adenine dinucleotide binding
PF547_13600	COG2851	Citrate transporter
PF547_13655	COG1773	rubredoxin
PF547_13660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF547_13670	COG0583	DNA-binding transcription factor activity
PF547_13695	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PF547_13700	COG4181	ATPase activity
PF547_13745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PF547_13765	COG0306	phosphate transporter
PF547_13775	COG3958	Transketolase
PF547_13780	COG3959	Transketolase, thiamine diphosphate binding domain
PF547_13785	COG2271	Major facilitator Superfamily
PF547_13790	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_13795	COG0583	DNA-binding transcription factor activity
PF547_13810	COG2223	nitrite transmembrane transporter activity
PF547_13815	COG2207	Transcriptional regulator
PF547_13820	COG2066	Belongs to the glutaminase family
PF547_13825	COG0242	peptide deformylase activity
PF547_13830	COG0477	Major facilitator Superfamily
PF547_13840	COG0028	Belongs to the TPP enzyme family
PF547_13855	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_13860	COG2267	carboxylic ester hydrolase activity
PF547_13870	COG2271	Major facilitator Superfamily
PF547_13875	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF547_13885	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_13905	COG1414	Transcriptional regulator
PF547_13920	COG1024	Enoyl-CoA hydratase
PF547_13930	COG1215	transferase activity, transferring glycosyl groups
PF547_13935	COG0726	polysaccharide deacetylase
PF547_13935	COG1649	PFAM Uncharacterised BCR, COG1649
PF547_13945	COG4681	YaeQ
PF547_13955	COG0523	cobalamin synthesis protein
PF547_13965	COG1607	acyl-coa hydrolase
PF547_13975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF547_13980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF547_13985	COG1309	transcriptional regulator
PF547_14010	COG2040	homocysteine
PF547_14015	COG0531	amino acid
PF547_14070	COG1595	DNA-templated transcription, initiation
PF547_14080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF547_14085	COG0477	Major facilitator Superfamily
PF547_14105	COG0084	hydrolase, TatD family'
PF547_14140	COG0629	single-stranded DNA binding
PF547_14195	COG0582	viral genome integration into host DNA
PF547_14295	COG0592	DNA-directed DNA polymerase activity
PF547_14335	COG2026	Addiction module toxin, RelE StbE family
PF547_14550	COG1484	DNA-dependent DNA replication
PF547_14640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF547_14710	COG0405	Gamma-glutamyltransferase
PF547_14715	COG2814	Major facilitator Superfamily
PF547_14730	COG2050	protein possibly involved in aromatic compounds catabolism
PF547_14745	COG1090	epimerase
PF547_14765	COG0420	3'-5' exonuclease activity
PF547_14790	COG0735	belongs to the Fur family
PF547_14795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PF547_14815	COG0121	glutamine amidotransferase
PF547_14830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF547_14840	COG0210	DNA helicase
PF547_14845	COG2885	chlorophyll binding
PF547_14850	COG0204	Acyl-transferase
PF547_14865	COG2894	cell division
PF547_14885	COG1280	lysine exporter protein (LysE YggA)
PF547_14890	COG1674	ftsk spoiiie
PF547_14890	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PF547_14895	COG0492	ferredoxin-NADP+ reductase activity
PF547_14900	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PF547_14910	COG0456	acetyltransferase
PF547_15035	COG4695	Portal protein
PF547_15115	COG0305	Participates in initiation and elongation during chromosome replication
PF547_15210	COG1981	membrane
PF547_15225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF547_15225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PF547_15245	COG1012	belongs to the aldehyde dehydrogenase family
PF547_15255	COG0657	acetylesterase activity
PF547_15265	COG0473	3-isopropylmalate dehydrogenase activity
PF547_15270	COG0583	DNA-binding transcription factor activity
PF547_15290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF547_15315	COG0564	pseudouridine synthase activity
PF547_15325	COG0358	DNA primase activity
PF547_15340	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PF547_15365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF547_15395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PF547_15405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF547_15405	COG0352	thiamine-phosphate diphosphorylase activity
PF547_15405	COG0351	phosphomethylpyrimidine kinase
PF547_15410	COG1652	LysM domain
PF547_15435	COG1399	metal-binding, possibly nucleic acid-binding protein
PF547_15440	COG3101	peptidyl-lysine hydroxylation
PF547_15445	COG0009	L-threonylcarbamoyladenylate synthase
PF547_15450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PF547_15455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PF547_15470	COG4106	trans-aconitate 2-methyltransferase activity
PF547_15485	COG0596	Alpha beta hydrolase
PF547_15485	COG2226	methyltransferase
PF547_15485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF547_15490	COG1877	trehalose-phosphatase activity
PF547_15495	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
PF547_15500	COG2223	nitrite transmembrane transporter activity
PF547_15520	COG1196	nuclear chromosome segregation
PF547_15530	COG0730	response to heat
PF547_15545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PF547_15555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF547_15605	COG0489	protein tyrosine kinase activity
PF547_15615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF547_15615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF547_15645	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PF547_15650	COG2081	HI0933 family
PF547_15680	COG0583	DNA-binding transcription factor activity
PF547_15700	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PF547_15705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF547_15735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PF547_15775	COG0745	RESPONSE REGULATOR receiver
PF547_15795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF547_15810	COG2205	protein histidine kinase activity
PF547_15880	COG4993	Dehydrogenase
PF547_15905	COG0384	phenazine biosynthesis protein PhzF
PF547_15930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF547_15945	COG0583	DNA-binding transcription factor activity
PF547_15975	COG0583	DNA-binding transcription factor activity
PF547_15990	COG0583	DNA-binding transcription factor activity
PF547_15995	COG1053	succinate dehydrogenase
PF547_16005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PF547_16010	COG2814	Major facilitator Superfamily
PF547_16015	COG1960	acyl-CoA dehydrogenase activity
PF547_16020	COG0583	DNA-binding transcription factor activity
PF547_16025	COG1063	alcohol dehydrogenase
PF547_16055	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PF547_16060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PF547_16065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF547_16080	COG3667	copper resistance
PF547_16085	COG2132	Multicopper oxidase
PF547_16095	COG0561	phosphatase activity
PF547_16100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PF547_16125	COG1214	PFAM Peptidase M22, glycoprotease
PF547_16180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF547_16190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PF547_16195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PF547_16200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF547_16260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF547_16270	COG1846	Transcriptional regulator
PF547_16275	COG1764	response to oxidative stress
PF547_16325	COG0037	tRNA processing
PF547_16335	COG0248	Ppx GppA phosphatase
PF547_16365	COG0072	phenylalanine-tRNA ligase activity
PF547_16410	COG1238	metal cluster binding
PF547_16415	COG0625	glutathione transferase activity
PF547_16430	COG0318	PFAM AMP-dependent synthetase and ligase
PF547_16435	COG3028	Belongs to the UPF0307 family
PF547_16440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF547_16460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PF547_16465	COG0617	tRNA 3'-terminal CCA addition
PF547_16470	COG1555	photosystem II stabilization
PF547_16475	COG3956	TIGRFAM MazG family protein
PF547_16485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF547_16505	COG2205	protein histidine kinase activity
PF547_16505	COG5002	protein histidine kinase activity
PF547_16505	COG0784	Response regulator, receiver
PF547_16510	COG1024	Enoyl-CoA hydratase
PF547_16515	COG2084	Dehydrogenase
PF547_16520	COG3622	Belongs to the hyi family
PF547_16550	COG0697	spore germination
PF547_16560	COG2814	Major facilitator Superfamily
PF547_16565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF547_16575	COG0583	DNA-binding transcription factor activity
PF547_16585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PF547_16600	COG0084	hydrolase, TatD family'
PF547_16615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PF547_16645	COG0440	acetolactate synthase activity
PF547_16650	COG0028	Belongs to the TPP enzyme family
PF547_16675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF547_16680	COG1136	(ABC) transporter
PF547_16680	COG0577	efflux transmembrane transporter activity
PF547_16685	COG1538	Outer membrane efflux protein
PF547_16700	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PF547_16705	COG1162	GTPase activity
PF547_16715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PF547_16735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF547_16740	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_16780	COG2986	histidine ammonia-lyase
PF547_16795	COG0318	PFAM AMP-dependent synthetase and ligase
PF547_16805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF547_16850	COG1426	Protein conserved in bacteria
PF547_16885	COG0793	Belongs to the peptidase S41A family
PF547_16900	COG2267	carboxylic ester hydrolase activity
PF547_16910	COG1012	belongs to the aldehyde dehydrogenase family
PF547_16915	COG3265	gluconokinase activity
PF547_16925	COG0800	Aldolase
PF547_16940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PF547_16945	COG0857	belongs to the CobB CobQ family
PF547_16945	COG0280	phosphate acetyltransferase
PF547_16950	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
PF547_16950	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
PF547_16970	COG0740	serine-type endopeptidase activity
PF547_16980	COG4774	siderophore transport
PF547_16990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF547_17000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF547_17000	COG2813	Specifically methylates the guanine in position
PF547_17100	COG0788	formyltetrahydrofolate deformylase activity
PF547_17125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF547_17125	COG4651	solute:proton antiporter activity
PF547_17145	COG0724	RNA recognition motif
PF547_17150	COG0210	DNA helicase
PF547_17175	COG1733	regulation of RNA biosynthetic process
PF547_17185	COG2900	Belongs to the SlyX family
PF547_17190	COG0488	(ABC) transporter
PF547_17195	COG1280	lysine exporter protein (LysE YggA)
PF547_17200	COG1560	Kdo2-lipid A biosynthetic process
PF547_17210	COG1301	dicarboxylic acid transport
PF547_17265	COG0473	3-isopropylmalate dehydrogenase activity
PF547_17330	COG0583	DNA-binding transcription factor activity
PF547_17340	COG0625	glutathione transferase activity
PF547_17345	COG2378	regulation of single-species biofilm formation
PF547_17350	COG0546	phosphoglycolate phosphatase activity
PF547_17360	COG1530	ribonuclease E activity
PF547_17365	COG0318	PFAM AMP-dependent synthetase and ligase
PF547_17380	COG0583	DNA-binding transcription factor activity
PF547_17385	COG4221	oxidoreductase activity
PF547_17390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF547_17400	COG0534	Mate efflux family protein
PF547_17415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PF547_17455	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PF547_17460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF547_17475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF547_17485	COG0644	oxidoreductase
PF547_17485	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
PF547_17490	COG0425	Belongs to the sulfur carrier protein TusA family
PF547_17495	COG4535	Mg2 and Co2 transporter CorC
PF547_17505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF547_17525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF547_17530	COG0475	glutathione-regulated potassium exporter activity
PF547_17530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF547_17535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PF547_17545	COG0484	heat shock protein binding
PF547_17550	COG0789	Transcriptional regulator
PF547_17555	COG0598	Magnesium transport protein CorA
PF547_17570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF547_17575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF547_17580	COG1074	ATP-dependent DNA helicase activity
PF547_17585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PF547_17605	COG2226	methyltransferase
PF547_17620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF547_17625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PF547_17640	COG2111	Na H antiporter
PF547_17640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF547_17645	COG1006	Multisubunit Na H antiporter MnhC subunit
PF547_17650	COG0651	ATP synthesis coupled electron transport
PF547_17655	COG1863	multisubunit Na H antiporter MnhE subunit
PF547_17660	COG2212	antiporter activity
PF547_17665	COG1320	monovalent cation:proton antiporter activity
PF547_17680	COG0195	Participates in both transcription termination and antitermination
PF547_17730	COG0237	dephospho-CoA kinase activity
PF547_17740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF547_17755	COG0497	DNA recombination
PF547_17765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PF547_17795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF547_17795	COG2169	Transcriptional regulator
PF547_17800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PF547_17865	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF547_17880	COG0326	Molecular chaperone. Has ATPase activity
PF547_17895	COG2056	Na+-H+ antiporter family
PF547_17900	COG0596	Alpha beta hydrolase
PF547_17995	COG0546	phosphoglycolate phosphatase activity
PF547_18000	COG1716	ATPase activity
PF547_18045	COG0181	hydroxymethylbilane synthase activity
PF547_18055	COG3275	phosphorelay sensor kinase activity
PF547_18075	COG1538	Outer membrane efflux protein
PF547_18080	COG0697	spore germination
PF547_18105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF547_18110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF547_18115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF547_18120	COG0772	Belongs to the SEDS family
PF547_18145	COG4974	Belongs to the 'phage' integrase family
PF547_18150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF547_18160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PF547_18170	COG2197	response regulator
PF547_18185	COG0793	Belongs to the peptidase S41A family
PF547_18190	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PF547_18195	COG0795	lipopolysaccharide-transporting ATPase activity
PF547_18235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF547_18235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF547_18245	COG0004	ammonium transporteR
PF547_18250	COG0347	Belongs to the P(II) protein family
PF547_18325	COG1061	Type III restriction enzyme res subunit
PF547_18330	COG1002	Type II restriction enzyme, methylase subunits
PF547_18340	COG0659	secondary active sulfate transmembrane transporter activity
PF547_18345	COG0589	response to stress
PF547_18400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF547_18420	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PF547_18435	COG0318	PFAM AMP-dependent synthetase and ligase
PF547_18445	COG0477	Major facilitator Superfamily
PF547_18450	COG2860	membrane
PF547_18460	COG1253	flavin adenine dinucleotide binding
PF547_18480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF547_18520	COG0655	NAD(P)H dehydrogenase (quinone) activity
PF547_18530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF547_18600	COG0758	DNA mediated transformation
PF547_18610	COG0697	spore germination
PF547_18615	COG1309	transcriptional regulator
PF547_18630	COG0386	Belongs to the glutathione peroxidase family
PF547_18695	COG1121	(ABC) transporter
PF547_18700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF547_18705	COG1280	lysine exporter protein (LysE YggA)
PF547_18710	COG2837	iron assimilation
PF547_18720	COG0281	malic enzyme
PF547_18765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF547_18765	COG0519	Catalyzes the synthesis of GMP from XMP
PF547_18770	COG4399	Belongs to the UPF0754 family
PF547_18775	COG2259	Doxx family
PF547_18780	COG0586	Pfam SNARE associated Golgi protein
PF547_18795	COG1192	Involved in chromosome partitioning
PF547_18805	COG0271	Belongs to the BolA IbaG family
PF547_18825	COG2267	carboxylic ester hydrolase activity
PF547_18845	COG3321	synthase
PF547_18845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PF547_18845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF547_18845	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF547_18850	COG1960	acyl-CoA dehydrogenase activity
PF547_18860	COG2197	response regulator
PF547_18870	COG3916	Acyl-homoserine-lactone synthase
PF547_18875	COG0477	Major facilitator Superfamily
PF547_18880	COG1024	Enoyl-CoA hydratase
PF547_18885	COG1024	Enoyl-CoA hydratase
PF547_18890	COG1960	acyl-CoA dehydrogenase activity
PF547_18895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF547_18915	COG1113	amino acid transport
PF547_18920	COG1113	amino acid transport
PF547_18925	COG0251	oxidation-reduction process
PF547_18965	COG0564	pseudouridine synthase activity
PF547_19025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PF547_19040	COG1802	Transcriptional regulator
PF547_19050	COG1448	Aminotransferase
PF547_19055	COG0277	FAD linked oxidase domain protein
PF547_19065	COG2186	Transcriptional regulator
PF547_19075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF547_19080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF547_19095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF547_19100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PF547_19125	COG0438	transferase activity, transferring glycosyl groups
PF547_19155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PF547_19185	COG0728	peptidoglycan biosynthetic process
PF547_19190	COG3023	N-Acetylmuramoyl-L-alanine amidase
PF547_19250	COG0546	phosphoglycolate phosphatase activity
PF547_19255	COG1028	Short-chain dehydrogenase reductase Sdr
PF547_19275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF547_19280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF547_19285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF547_19290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF547_19295	COG1116	anion transmembrane transporter activity
PF547_19300	COG1309	transcriptional regulator
PF547_19305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PF547_19315	COG0196	riboflavin kinase activity
PF547_19320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PF547_19330	COG1047	Peptidyl-prolyl cis-trans
PF547_19370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PF547_19375	COG0657	acetylesterase activity
PF547_19395	COG0583	DNA-binding transcription factor activity
PF547_19425	COG2951	lytic endotransglycosylase activity
PF547_19430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PF547_19445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PF547_19455	COG0671	phosphoesterase, PA-phosphatase related
PF547_19460	COG0861	Integral membrane protein TerC family
PF547_19470	COG0754	glutathionylspermidine amidase activity
PF547_19480	COG0402	S-adenosylhomocysteine deaminase activity
PF547_19495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF547_19500	COG1230	cation diffusion facilitator family transporter
PF547_19515	COG0706	membrane insertase activity
PF547_19585	COG1525	nuclease
PF547_19650	COG1475	DNA binding
PF547_19665	COG3853	Toxic anion resistance protein (TelA)
PF547_19845	COG0741	lytic transglycosylase activity
PF547_19880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process