locus-tag	class	description
PF364_00010	COG0592	DNA-directed DNA polymerase activity
PF364_00020	COG0187	DNA topoisomerase II activity
PF364_00030	COG0586	Pfam SNARE associated Golgi protein
PF364_00035	COG0488	(ABC) transporter
PF364_00060	COG0596	Alpha beta hydrolase
PF364_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PF364_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PF364_00110	COG1047	Peptidyl-prolyl cis-trans
PF364_00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PF364_00125	COG0196	riboflavin kinase activity
PF364_00135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PF364_00140	COG1309	transcriptional regulator
PF364_00145	COG1116	anion transmembrane transporter activity
PF364_00150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF364_00170	COG0488	(ABC) transporter
PF364_00220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PF364_00285	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_00290	COG0546	phosphoglycolate phosphatase activity
PF364_00315	COG1017	nitric oxide dioxygenase activity
PF364_00315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF364_00350	COG3023	N-Acetylmuramoyl-L-alanine amidase
PF364_00355	COG0728	peptidoglycan biosynthetic process
PF364_00385	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PF364_00405	COG0438	transferase activity, transferring glycosyl groups
PF364_00420	COG1002	Type II restriction enzyme, methylase subunits
PF364_00425	COG1061	Type III restriction enzyme res subunit
PF364_00460	COG0438	transferase activity, transferring glycosyl groups
PF364_00465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PF364_00475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF364_00485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF364_00500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF364_00505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF364_00515	COG2186	Transcriptional regulator
PF364_00525	COG0277	FAD linked oxidase domain protein
PF364_00530	COG1448	Aminotransferase
PF364_00540	COG1802	Transcriptional regulator
PF364_00555	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PF364_00575	COG1051	belongs to the nudix hydrolase family
PF364_00605	COG0564	pseudouridine synthase activity
PF364_00645	COG0251	oxidation-reduction process
PF364_00650	COG1113	amino acid transport
PF364_00655	COG1113	amino acid transport
PF364_00675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF364_00680	COG1960	acyl-CoA dehydrogenase activity
PF364_00685	COG1024	Enoyl-CoA hydratase
PF364_00690	COG1024	Enoyl-CoA hydratase
PF364_00695	COG0477	Major facilitator Superfamily
PF364_00700	COG3916	Acyl-homoserine-lactone synthase
PF364_00710	COG2197	response regulator
PF364_00720	COG1960	acyl-CoA dehydrogenase activity
PF364_00725	COG3321	synthase
PF364_00725	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF364_00725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PF364_00725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF364_00745	COG2267	carboxylic ester hydrolase activity
PF364_00765	COG0271	Belongs to the BolA IbaG family
PF364_00775	COG1192	Involved in chromosome partitioning
PF364_00790	COG0586	Pfam SNARE associated Golgi protein
PF364_00795	COG2259	Doxx family
PF364_00800	COG4399	Belongs to the UPF0754 family
PF364_00805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF364_00805	COG0519	Catalyzes the synthesis of GMP from XMP
PF364_00850	COG0281	malic enzyme
PF364_00860	COG2837	iron assimilation
PF364_00865	COG1280	lysine exporter protein (LysE YggA)
PF364_00870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF364_00875	COG1121	(ABC) transporter
PF364_00940	COG0386	Belongs to the glutathione peroxidase family
PF364_00955	COG1309	transcriptional regulator
PF364_00960	COG0697	spore germination
PF364_00970	COG0758	DNA mediated transformation
PF364_01040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF364_01050	COG0655	NAD(P)H dehydrogenase (quinone) activity
PF364_01090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF364_01095	COG3757	hydrolase, family 25
PF364_01100	COG0477	Major facilitator Superfamily
PF364_01110	COG1253	flavin adenine dinucleotide binding
PF364_01120	COG2860	membrane
PF364_01125	COG0477	Major facilitator Superfamily
PF364_01135	COG0318	PFAM AMP-dependent synthetase and ligase
PF364_01150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PF364_01165	COG1002	Type II restriction enzyme, methylase subunits
PF364_01170	COG1061	Type III restriction enzyme res subunit
PF364_01205	COG0347	Belongs to the P(II) protein family
PF364_01210	COG0004	ammonium transporteR
PF364_01220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF364_01220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF364_01260	COG0795	lipopolysaccharide-transporting ATPase activity
PF364_01265	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PF364_01270	COG0793	Belongs to the peptidase S41A family
PF364_01285	COG2197	response regulator
PF364_01295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PF364_01305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF364_01310	COG4974	Belongs to the 'phage' integrase family
PF364_01335	COG0772	Belongs to the SEDS family
PF364_01340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF364_01345	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF364_01350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF364_01380	COG1538	Outer membrane efflux protein
PF364_01400	COG3275	phosphorelay sensor kinase activity
PF364_01410	COG0181	hydroxymethylbilane synthase activity
PF364_01455	COG1716	ATPase activity
PF364_01460	COG0546	phosphoglycolate phosphatase activity
PF364_01560	COG2056	Na+-H+ antiporter family
PF364_01575	COG0326	Molecular chaperone. Has ATPase activity
PF364_01590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF364_01650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PF364_01655	COG2169	Transcriptional regulator
PF364_01655	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF364_01685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PF364_01695	COG0497	DNA recombination
PF364_01710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF364_01720	COG0237	dephospho-CoA kinase activity
PF364_01770	COG0195	Participates in both transcription termination and antitermination
PF364_01785	COG1320	monovalent cation:proton antiporter activity
PF364_01790	COG2212	antiporter activity
PF364_01795	COG1863	multisubunit Na H antiporter MnhE subunit
PF364_01800	COG0651	ATP synthesis coupled electron transport
PF364_01805	COG1006	Multisubunit Na H antiporter MnhC subunit
PF364_01810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF364_01810	COG2111	Na H antiporter
PF364_01825	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PF364_01845	COG2226	methyltransferase
PF364_01865	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PF364_01870	COG1074	ATP-dependent DNA helicase activity
PF364_01875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF364_01880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF364_01895	COG0598	Magnesium transport protein CorA
PF364_01900	COG0789	Transcriptional regulator
PF364_01905	COG0484	heat shock protein binding
PF364_01920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF364_01920	COG0475	glutathione-regulated potassium exporter activity
PF364_01925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF364_01945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF364_01955	COG4535	Mg2 and Co2 transporter CorC
PF364_01960	COG0425	Belongs to the sulfur carrier protein TusA family
PF364_01970	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
PF364_01970	COG0644	oxidoreductase
PF364_01980	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF364_01995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF364_02000	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PF364_02010	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF364_02010	COG0493	'glutamate synthase
PF364_02035	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PF364_02050	COG0534	Mate efflux family protein
PF364_02060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF364_02065	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_02070	COG0583	DNA-binding transcription factor activity
PF364_02085	COG0318	PFAM AMP-dependent synthetase and ligase
PF364_02090	COG1530	ribonuclease E activity
PF364_02115	COG2378	regulation of single-species biofilm formation
PF364_02120	COG0625	glutathione transferase activity
PF364_02130	COG0583	DNA-binding transcription factor activity
PF364_02190	COG0473	3-isopropylmalate dehydrogenase activity
PF364_02245	COG1301	dicarboxylic acid transport
PF364_02255	COG1560	Kdo2-lipid A biosynthetic process
PF364_02260	COG1280	lysine exporter protein (LysE YggA)
PF364_02265	COG0488	(ABC) transporter
PF364_02270	COG2900	Belongs to the SlyX family
PF364_02280	COG1733	regulation of RNA biosynthetic process
PF364_02305	COG0210	DNA helicase
PF364_02310	COG0724	RNA recognition motif
PF364_02330	COG4651	solute:proton antiporter activity
PF364_02330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF364_02355	COG0788	formyltetrahydrofolate deformylase activity
PF364_02455	COG2813	Specifically methylates the guanine in position
PF364_02455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF364_02465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF364_02475	COG4774	siderophore transport
PF364_02485	COG0740	serine-type endopeptidase activity
PF364_02505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
PF364_02505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
PF364_02510	COG0857	belongs to the CobB CobQ family
PF364_02510	COG0280	phosphate acetyltransferase
PF364_02515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PF364_02525	COG0800	Aldolase
PF364_02535	COG3265	gluconokinase activity
PF364_02540	COG1012	belongs to the aldehyde dehydrogenase family
PF364_02550	COG2267	carboxylic ester hydrolase activity
PF364_02565	COG0793	Belongs to the peptidase S41A family
PF364_02600	COG1426	Protein conserved in bacteria
PF364_02640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PF364_02650	COG1162	GTPase activity
PF364_02655	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PF364_02670	COG1538	Outer membrane efflux protein
PF364_02675	COG0577	efflux transmembrane transporter activity
PF364_02675	COG1136	(ABC) transporter
PF364_02680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF364_02705	COG0028	Belongs to the TPP enzyme family
PF364_02710	COG0440	acetolactate synthase activity
PF364_02740	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PF364_02755	COG0084	hydrolase, TatD family'
PF364_02765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PF364_02775	COG0583	DNA-binding transcription factor activity
PF364_02785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF364_02855	COG1294	oxidase, subunit
PF364_02860	COG1271	oxidase subunit
PF364_02875	COG4774	siderophore transport
PF364_02945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF364_02955	COG2814	Major facilitator Superfamily
PF364_02965	COG0697	spore germination
PF364_03000	COG3622	Belongs to the hyi family
PF364_03005	COG2084	Dehydrogenase
PF364_03010	COG1024	Enoyl-CoA hydratase
PF364_03015	COG0784	Response regulator, receiver
PF364_03015	COG2205	protein histidine kinase activity
PF364_03015	COG5002	protein histidine kinase activity
PF364_03035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF364_03045	COG3956	TIGRFAM MazG family protein
PF364_03050	COG1555	photosystem II stabilization
PF364_03055	COG0617	tRNA 3'-terminal CCA addition
PF364_03060	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PF364_03080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF364_03085	COG3028	Belongs to the UPF0307 family
PF364_03090	COG0318	PFAM AMP-dependent synthetase and ligase
PF364_03105	COG0625	glutathione transferase activity
PF364_03110	COG1238	metal cluster binding
PF364_03155	COG0072	phenylalanine-tRNA ligase activity
PF364_03185	COG0248	Ppx GppA phosphatase
PF364_03195	COG0037	tRNA processing
PF364_03235	COG1764	response to oxidative stress
PF364_03240	COG1846	Transcriptional regulator
PF364_03250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF364_03310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF364_03315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PF364_03320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PF364_03390	COG1214	PFAM Peptidase M22, glycoprotease
PF364_03405	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
PF364_03415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PF364_03420	COG0561	phosphatase activity
PF364_03430	COG2132	Multicopper oxidase
PF364_03450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF364_03455	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PF364_03460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PF364_03490	COG1063	alcohol dehydrogenase
PF364_03495	COG0583	DNA-binding transcription factor activity
PF364_03500	COG1960	acyl-CoA dehydrogenase activity
PF364_03505	COG2814	Major facilitator Superfamily
PF364_03510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PF364_03520	COG1053	succinate dehydrogenase
PF364_03525	COG0583	DNA-binding transcription factor activity
PF364_03540	COG0583	DNA-binding transcription factor activity
PF364_03550	COG0583	DNA-binding transcription factor activity
PF364_03565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF364_03610	COG0384	phenazine biosynthesis protein PhzF
PF364_03630	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_03640	COG0477	Major facilitator Superfamily
PF364_03675	COG0697	spore germination
PF364_03680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF364_03700	COG0745	RESPONSE REGULATOR receiver
PF364_03740	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PF364_03770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF364_03775	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PF364_03800	COG0583	DNA-binding transcription factor activity
PF364_03820	COG0668	transmembrane transport
PF364_03830	COG2081	HI0933 family
PF364_03835	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PF364_03865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF364_03865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF364_03875	COG0489	protein tyrosine kinase activity
PF364_03935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF364_03945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PF364_03960	COG0730	response to heat
PF364_03970	COG1196	nuclear chromosome segregation
PF364_03990	COG2223	nitrite transmembrane transporter activity
PF364_03995	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
PF364_04000	COG1877	trehalose-phosphatase activity
PF364_04005	COG2226	methyltransferase
PF364_04005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF364_04005	COG0596	Alpha beta hydrolase
PF364_04020	COG4106	trans-aconitate 2-methyltransferase activity
PF364_04035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PF364_04040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PF364_04045	COG0009	L-threonylcarbamoyladenylate synthase
PF364_04050	COG3101	peptidyl-lysine hydroxylation
PF364_04055	COG1399	metal-binding, possibly nucleic acid-binding protein
PF364_04080	COG1652	LysM domain
PF364_04085	COG0352	thiamine-phosphate diphosphorylase activity
PF364_04085	COG0351	phosphomethylpyrimidine kinase
PF364_04085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF364_04095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PF364_04125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF364_04155	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PF364_04170	COG0358	DNA primase activity
PF364_04180	COG0564	pseudouridine synthase activity
PF364_04205	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF364_04225	COG0583	DNA-binding transcription factor activity
PF364_04230	COG0473	3-isopropylmalate dehydrogenase activity
PF364_04240	COG0657	acetylesterase activity
PF364_04250	COG1012	belongs to the aldehyde dehydrogenase family
PF364_04270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF364_04270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PF364_04285	COG1981	membrane
PF364_04330	COG0456	acetyltransferase
PF364_04340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PF364_04345	COG0492	ferredoxin-NADP+ reductase activity
PF364_04350	COG1674	ftsk spoiiie
PF364_04350	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PF364_04355	COG1280	lysine exporter protein (LysE YggA)
PF364_04370	COG2894	cell division
PF364_04385	COG0204	Acyl-transferase
PF364_04390	COG2885	chlorophyll binding
PF364_04395	COG0210	DNA helicase
PF364_04405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF364_04420	COG0121	glutamine amidotransferase
PF364_04440	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PF364_04445	COG0735	belongs to the Fur family
PF364_04470	COG0420	3'-5' exonuclease activity
PF364_04490	COG1090	epimerase
PF364_04505	COG2050	protein possibly involved in aromatic compounds catabolism
PF364_04515	COG2814	Major facilitator Superfamily
PF364_04520	COG0405	Gamma-glutamyltransferase
PF364_04590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF364_04680	COG1484	DNA-dependent DNA replication
PF364_04885	COG2026	Addiction module toxin, RelE StbE family
PF364_04925	COG0592	DNA-directed DNA polymerase activity
PF364_05025	COG0582	viral genome integration into host DNA
PF364_05070	COG0629	single-stranded DNA binding
PF364_05130	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
PF364_05140	COG0477	Major facilitator Superfamily
PF364_05145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF364_05155	COG1595	DNA-templated transcription, initiation
PF364_05210	COG0531	amino acid
PF364_05215	COG2040	homocysteine
PF364_05240	COG1309	transcriptional regulator
PF364_05245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF364_05250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF364_05260	COG1607	acyl-coa hydrolase
PF364_05270	COG0523	cobalamin synthesis protein
PF364_05280	COG4681	YaeQ
PF364_05290	COG0726	polysaccharide deacetylase
PF364_05290	COG1649	PFAM Uncharacterised BCR, COG1649
PF364_05295	COG1215	transferase activity, transferring glycosyl groups
PF364_05305	COG1024	Enoyl-CoA hydratase
PF364_05320	COG1414	Transcriptional regulator
PF364_05340	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_05350	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF364_05355	COG2271	Major facilitator Superfamily
PF364_05365	COG2267	carboxylic ester hydrolase activity
PF364_05370	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_05385	COG0028	Belongs to the TPP enzyme family
PF364_05395	COG0477	Major facilitator Superfamily
PF364_05400	COG0242	peptide deformylase activity
PF364_05405	COG2066	Belongs to the glutaminase family
PF364_05410	COG2207	Transcriptional regulator
PF364_05415	COG2223	nitrite transmembrane transporter activity
PF364_05430	COG0583	DNA-binding transcription factor activity
PF364_05435	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_05440	COG2271	Major facilitator Superfamily
PF364_05445	COG3959	Transketolase, thiamine diphosphate binding domain
PF364_05450	COG3958	Transketolase
PF364_05460	COG0306	phosphate transporter
PF364_05480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PF364_05525	COG4181	ATPase activity
PF364_05530	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PF364_05560	COG0583	DNA-binding transcription factor activity
PF364_05570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF364_05575	COG1773	rubredoxin
PF364_05625	COG2851	Citrate transporter
PF364_05630	COG1253	flavin adenine dinucleotide binding
PF364_05670	COG0804	urea catabolic process
PF364_05680	COG0830	nickel cation binding
PF364_05695	COG0742	ribosomal rna small subunit methyltransferase
PF364_05700	COG0768	penicillin binding
PF364_05725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PF364_05730	COG2878	Part of a membrane complex involved in electron transport
PF364_05735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF364_05745	COG3384	dioxygenase
PF364_05765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PF364_05805	COG0006	proline dipeptidase activity
PF364_05810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF364_05815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF364_05835	COG1279	arginine transmembrane transporter activity
PF364_05840	COG0583	DNA-binding transcription factor activity
PF364_05880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF364_05885	COG0741	lytic transglycosylase activity
PF364_05885	COG1388	LysM domain
PF364_05885	COG0741	lytic transglycosylase activity
PF364_05885	COG1388	LysM domain
PF364_05895	COG4174	ABC transporter (Permease)
PF364_05900	COG4239	(ABC) transporter, permease
PF364_05905	COG4172	Belongs to the ABC transporter superfamily
PF364_05930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF364_05940	COG5001	Diguanylate cyclase
PF364_05940	COG2203	Gaf domain
PF364_05940	COG3706	GGDEF domain
PF364_05940	COG4251	negative regulation of phosphorylation
PF364_05950	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF364_05950	COG1902	pentaerythritol trinitrate reductase activity
PF364_05965	COG4269	membrane
PF364_05985	COG3209	COG3209 Rhs family protein
PF364_06025	COG1113	amino acid transport
PF364_06035	COG0531	amino acid
PF364_06055	COG1012	belongs to the aldehyde dehydrogenase family
PF364_06075	COG1113	amino acid transport
PF364_06120	COG0697	spore germination
PF364_06125	COG2721	sulfolactate sulfo-lyase activity
PF364_06130	COG2271	Major facilitator Superfamily
PF364_06135	COG4948	Mandelate Racemase Muconate Lactonizing
PF364_06145	COG1012	belongs to the aldehyde dehydrogenase family
PF364_06150	COG2186	Transcriptional regulator
PF364_06175	COG1960	acyl-CoA dehydrogenase activity
PF364_06185	COG1012	belongs to the aldehyde dehydrogenase family
PF364_06190	COG1024	Enoyl-CoA hydratase
PF364_06195	COG2814	Major facilitator Superfamily
PF364_06215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF364_06265	COG2072	flavoprotein involved in K transport
PF364_06270	COG0300	oxidoreductase activity
PF364_06280	COG1309	transcriptional regulator
PF364_06285	COG1741	Belongs to the pirin family
PF364_06305	COG2072	flavoprotein involved in K transport
PF364_06315	COG2252	PERMEase
PF364_06320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PF364_06325	COG3038	cytochrome b561
PF364_06345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PF364_06355	COG0527	aspartate kinase activity
PF364_06365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF364_06380	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PF364_06395	COG0667	Aldo Keto reductase
PF364_06410	COG1765	OsmC-like protein
PF364_06425	COG0542	response to heat
PF364_06460	COG2885	chlorophyll binding
PF364_06470	COG0625	glutathione transferase activity
PF364_06630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PF364_06650	COG3634	alkyl hydroperoxide reductase activity
PF364_06660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PF364_06670	COG0450	alkyl hydroperoxide reductase
PF364_06675	COG1643	Atp-dependent helicase
PF364_06690	COG2814	Major facilitator Superfamily
PF364_06695	COG3135	benzoate transporter
PF364_06700	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_06705	COG0543	2 iron, 2 sulfur cluster binding
PF364_06705	COG0633	Ferredoxin
PF364_06715	COG4638	Rieske (2fe-2S)
PF364_06725	COG0583	DNA-binding transcription factor activity
PF364_06775	COG1570	exodeoxyribonuclease VII activity
PF364_06805	COG1280	lysine exporter protein (LysE YggA)
PF364_06810	COG1278	Cold shock
PF364_06845	COG2814	Major facilitator Superfamily
PF364_06885	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PF364_06885	COG0517	IMP dehydrogenase activity
PF364_06890	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PF364_06900	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PF364_06905	COG1137	ATPase activity
PF364_06910	COG1538	Outer membrane efflux protein
PF364_06940	COG4122	O-methyltransferase activity
PF364_06950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PF364_06965	COG1522	sequence-specific DNA binding
PF364_06970	COG5006	permease, DMT superfamily
PF364_06980	COG1560	Kdo2-lipid A biosynthetic process
PF364_06990	COG0598	Magnesium transport protein CorA
PF364_07020	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PF364_07025	COG1116	anion transmembrane transporter activity
PF364_07030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF364_07055	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF364_07115	COG1914	H( )-stimulated, divalent metal cation uptake system
PF364_07135	COG4770	biotin carboxylase activity
PF364_07140	COG0038	chloride channel
PF364_07180	COG1309	transcriptional regulator
PF364_07190	COG1063	alcohol dehydrogenase
PF364_07205	COG0439	Biotin carboxylase
PF364_07210	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF364_07215	COG1733	regulation of RNA biosynthetic process
PF364_07225	COG0864	Transcriptional regulator
PF364_07235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF364_07240	COG1116	anion transmembrane transporter activity
PF364_07360	COG0590	tRNA wobble adenosine to inosine editing
PF364_07365	COG2807	transmembrane transport
PF364_07380	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PF364_07390	COG0789	Transcriptional regulator
PF364_07400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF364_07420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF364_07445	COG1012	belongs to the aldehyde dehydrogenase family
PF364_07450	COG0531	amino acid
PF364_07455	COG1760	l-serine dehydratase
PF364_07460	COG2030	dehydratase
PF364_07460	COG1012	belongs to the aldehyde dehydrogenase family
PF364_07465	COG3396	Phenylacetate-CoA oxygenase
PF364_07470	COG3460	Phenylacetate-CoA oxygenase
PF364_07475	COG3396	Phenylacetate-CoA oxygenase
PF364_07480	COG2151	metal-sulfur cluster biosynthetic enzyme
PF364_07485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF364_07490	COG1024	Enoyl-CoA hydratase
PF364_07495	COG1024	Enoyl-CoA hydratase
PF364_07500	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF364_07505	COG0183	Belongs to the thiolase family
PF364_07510	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PF364_07515	COG3327	negative regulation of DNA-templated transcription, initiation
PF364_07525	COG2050	protein possibly involved in aromatic compounds catabolism
PF364_07540	COG0406	alpha-ribazole phosphatase activity
PF364_07560	COG0753	catalase activity
PF364_07565	COG3038	cytochrome b561
PF364_07590	COG2267	carboxylic ester hydrolase activity
PF364_07595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF364_07600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF364_07605	COG1012	belongs to the aldehyde dehydrogenase family
PF364_07615	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF364_07625	COG1012	belongs to the aldehyde dehydrogenase family
PF364_07630	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF364_07635	COG0583	DNA-binding transcription factor activity
PF364_07645	COG1414	Transcriptional regulator
PF364_07650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF364_07665	COG1840	ABC-type Fe3 transport system, periplasmic component
PF364_07670	COG3842	ATPase activity
PF364_07690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF364_07710	COG0583	DNA-binding transcription factor activity
PF364_07720	COG4770	biotin carboxylase activity
PF364_07725	COG1024	Enoyl-CoA hydratase
PF364_07730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF364_07735	COG1960	acyl-CoA dehydrogenase activity
PF364_07740	COG1309	transcriptional regulator
PF364_07745	COG0318	PFAM AMP-dependent synthetase and ligase
PF364_07765	COG0583	DNA-binding transcription factor activity
PF364_07815	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_07835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PF364_07855	COG0784	Response regulator, receiver
PF364_07855	COG2205	protein histidine kinase activity
PF364_07875	COG0765	amino acid transport
PF364_07880	COG0765	amino acid transport
PF364_07885	COG1126	abc transporter atp-binding protein
PF364_07890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF364_07895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF364_07910	COG1280	lysine exporter protein (LysE YggA)
PF364_07920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF364_07925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF364_07930	COG1045	serine acetyltransferase
PF364_07945	COG0583	DNA-binding transcription factor activity
PF364_07950	COG0625	glutathione transferase activity
PF364_07955	COG0625	glutathione transferase activity
PF364_07960	COG0583	DNA-binding transcription factor activity
PF364_07970	COG1346	cytolysis
PF364_07990	COG2814	Major facilitator Superfamily
PF364_08000	COG0583	DNA-binding transcription factor activity
PF364_08010	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
PF364_08015	COG3052	prosthetic group binding
PF364_08035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF364_08060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF364_08070	COG1294	oxidase, subunit
PF364_08075	COG1271	oxidase subunit
PF364_08095	COG0477	Major facilitator Superfamily
PF364_08105	COG4521	taurine ABC transporter
PF364_08110	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PF364_08115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF364_08120	COG2175	clavaminate synthase activity
PF364_08130	COG1953	Uracil, thiamine, allantoin
PF364_08140	COG0583	DNA-binding transcription factor activity
PF364_08150	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PF364_08165	COG0640	Transcriptional regulator
PF364_08170	COG0798	PFAM Bile acid sodium symporter
PF364_08175	COG0583	DNA-binding transcription factor activity
PF364_08190	COG3634	alkyl hydroperoxide reductase activity
PF364_08225	COG1301	dicarboxylic acid transport
PF364_08230	COG0436	Aminotransferase
PF364_08240	COG0386	Belongs to the glutathione peroxidase family
PF364_08280	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF364_08305	COG0012	GTP binding
PF364_08310	COG2011	ABC-type metal ion transport system permease component
PF364_08315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF364_08325	COG1464	Belongs to the NlpA lipoprotein family
PF364_08355	COG0765	amino acid transport
PF364_08360	COG0765	amino acid transport
PF364_08365	COG1126	abc transporter atp-binding protein
PF364_08375	COG1522	sequence-specific DNA binding
PF364_08390	COG1309	transcriptional regulator
PF364_08410	COG0583	DNA-binding transcription factor activity
PF364_08420	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF364_08430	COG0697	spore germination
PF364_08455	COG3121	Chaperone
PF364_08460	COG3539	Fimbrial protein
PF364_08485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PF364_08485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PF364_08530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PF364_08540	COG2353	YceI-like domain
PF364_08550	COG3698	Phosphodiester glycosidase
PF364_08565	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PF364_08570	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PF364_08570	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PF364_08570	COG0506	proline dehydrogenase activity
PF364_08580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF364_08585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PF364_08605	COG1132	(ABC) transporter
PF364_08610	COG3122	Protein conserved in bacteria
PF364_08615	COG3619	membrane
PF364_08625	COG0640	Transcriptional regulator
PF364_08635	COG2850	peptidyl-arginine hydroxylation
PF364_08640	COG0424	maF-like protein
PF364_08660	COG0191	fructose-bisphosphate aldolase activity
PF364_08665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF364_08680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PF364_08690	COG1192	Involved in chromosome partitioning
PF364_08695	COG1475	DNA binding
PF364_08700	COG0811	peptide transport
PF364_08710	COG1132	(ABC) transporter
PF364_08715	COG1663	tetraacyldisaccharide 4'-kinase activity
PF364_08735	COG0084	hydrolase, TatD family'
PF364_08800	COG0776	regulation of translation
PF364_08830	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PF364_08835	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PF364_08870	COG4166	transmembrane transport
PF364_08880	COG0339	signal peptide processing
PF364_08890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF364_08940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PF364_08960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PF364_08990	COG0316	Belongs to the HesB IscA family
PF364_08995	COG0822	iron-sulfur transferase activity
PF364_09020	COG0776	regulation of translation
PF364_09025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF364_09030	COG2207	Transcriptional regulator
PF364_09035	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF364_09040	COG1960	acyl-CoA dehydrogenase activity
PF364_09045	COG1960	acyl-CoA dehydrogenase activity
PF364_09060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PF364_09075	COG2814	Major facilitator Superfamily
PF364_09080	COG4264	IucA IucC family
PF364_09085	COG4264	IucA IucC family
PF364_09095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PF364_09125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF364_09140	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PF364_09145	COG0406	alpha-ribazole phosphatase activity
PF364_09160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PF364_09165	COG0730	response to heat
PF364_09185	COG4773	Receptor
PF364_09190	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF364_09205	COG1131	(ABC) transporter
PF364_09210	COG0842	Transport permease protein
PF364_09215	COG0842	Transport permease protein
PF364_09270	COG2226	methyltransferase
PF364_09295	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PF364_09330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF364_09340	COG0133	tryptophan synthase activity
PF364_09355	COG3706	GGDEF domain
PF364_09370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF364_09375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF364_09380	COG0022	dehydrogenase e1 component
PF364_09385	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF364_09390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF364_09400	COG1063	alcohol dehydrogenase
PF364_09405	COG3781	membrane
PF364_09415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF364_09415	COG3453	Protein conserved in bacteria
PF364_09430	COG0730	response to heat
PF364_09445	COG2207	Transcriptional regulator
PF364_09445	COG3708	Transcriptional regulator
PF364_09450	COG1733	regulation of RNA biosynthetic process
PF364_09455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF364_09475	COG2188	Transcriptional regulator
PF364_09490	COG4521	taurine ABC transporter
PF364_09495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF364_09515	COG0477	Major facilitator Superfamily
PF364_09525	COG1027	Aspartate ammonia-lyase
PF364_09540	COG0583	DNA-binding transcription factor activity
PF364_09545	COG0583	DNA-binding transcription factor activity
PF364_09550	COG0183	Belongs to the thiolase family
PF364_09555	COG2031	fatty acid transporter
PF364_09570	COG0583	DNA-binding transcription factor activity
PF364_09580	COG2610	gluconate transmembrane transporter activity
PF364_09585	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_09590	COG2207	Transcriptional regulator
PF364_09605	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_09615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF364_09630	COG0543	2 iron, 2 sulfur cluster binding
PF364_09630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF364_09635	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
PF364_09640	COG4638	Rieske (2fe-2S)
PF364_09650	COG0725	ABC transporter, periplasmic molybdate-binding protein
PF364_09655	COG4149	molybdate abc transporter
PF364_09660	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PF364_09665	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_09670	COG1535	isochorismatase
PF364_09670	COG3433	isochorismatase activity
PF364_09730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF364_09745	COG0753	catalase activity
PF364_09755	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PF364_09785	COG3320	Male sterility
PF364_09785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF364_09790	COG2814	Major facilitator Superfamily
PF364_09815	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PF364_09865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF364_09885	COG1120	ATPase activity
PF364_09890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF364_09900	COG1064	alcohol dehydrogenase
PF364_09915	COG2207	Transcriptional regulator
PF364_09920	COG2084	Dehydrogenase
PF364_09930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF364_09935	COG0583	DNA-binding transcription factor activity
PF364_09945	COG0129	dihydroxy-acid dehydratase activity
PF364_09950	COG1012	belongs to the aldehyde dehydrogenase family
PF364_09955	COG1846	Transcriptional regulator
PF364_09960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF364_09965	COG1960	acyl-CoA dehydrogenase activity
PF364_09970	COG0477	Major facilitator Superfamily
PF364_09985	COG3971	2-oxopent-4-enoate hydratase activity
PF364_09995	COG3384	dioxygenase
PF364_10000	COG1012	belongs to the aldehyde dehydrogenase family
PF364_10010	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF364_10020	COG2814	Major facilitator Superfamily
PF364_10025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PF364_10040	COG1012	belongs to the aldehyde dehydrogenase family
PF364_10060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF364_10080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF364_10115	COG0583	DNA-binding transcription factor activity
PF364_10130	COG2188	Transcriptional regulator
PF364_10185	COG1473	amidohydrolase
PF364_10195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF364_10195	COG0475	glutathione-regulated potassium exporter activity
PF364_10205	COG0583	DNA-binding transcription factor activity
PF364_10210	COG1335	isochorismatase
PF364_10220	COG1309	transcriptional regulator
PF364_10255	COG1902	pentaerythritol trinitrate reductase activity
PF364_10255	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF364_10260	COG1846	Transcriptional regulator
PF364_10280	COG0753	catalase activity
PF364_10295	COG1012	belongs to the aldehyde dehydrogenase family
PF364_10310	COG3162	membrane
PF364_10320	COG3829	transcription factor binding
PF364_10325	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_10330	COG1960	acyl-CoA dehydrogenase activity
PF364_10345	COG3231	kanamycin kinase activity
PF364_10350	COG1012	belongs to the aldehyde dehydrogenase family
PF364_10370	COG2186	Transcriptional regulator
PF364_10380	COG0583	DNA-binding transcription factor activity
PF364_10385	COG4948	Mandelate Racemase Muconate Lactonizing
PF364_10390	COG4829	muconolactone delta-isomerase
PF364_10400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF364_10405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF364_10410	COG0183	Belongs to the thiolase family
PF364_10415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF364_10425	COG1012	belongs to the aldehyde dehydrogenase family
PF364_10435	COG3733	amine oxidase
PF364_10445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF364_10455	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_10465	COG4638	Rieske (2fe-2S)
PF364_10485	COG0154	amidase activity
PF364_10495	COG2814	Major facilitator Superfamily
PF364_10520	COG1960	acyl-CoA dehydrogenase activity
PF364_10525	COG0583	DNA-binding transcription factor activity
PF364_10530	COG1414	Transcriptional regulator
PF364_10545	COG2391	methyltransferase activity
PF364_10555	COG4993	Dehydrogenase
PF364_10560	COG3659	wide pore channel activity
PF364_10565	COG3420	alginic acid biosynthetic process
PF364_10570	COG0710	3-dehydroquinate dehydratase activity
PF364_10575	COG3485	protocatechuate 3,4-dioxygenase
PF364_10580	COG3485	protocatechuate 3,4-dioxygenase
PF364_10585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF364_10590	COG2271	Major facilitator Superfamily
PF364_10595	COG0596	Alpha beta hydrolase
PF364_10600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PF364_10605	COG0183	Belongs to the thiolase family
PF364_10610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF364_10615	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF364_10625	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PF364_10630	COG2323	membrane
PF364_10675	COG1902	pentaerythritol trinitrate reductase activity
PF364_10675	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF364_10690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PF364_10700	COG0542	response to heat
PF364_10705	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PF364_10735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF364_10740	COG0569	domain protein
PF364_10745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PF364_10760	COG4774	siderophore transport
PF364_10765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF364_10775	COG1585	Membrane protein implicated in regulation of membrane protease activity
PF364_10790	COG1294	oxidase, subunit
PF364_10795	COG4890	Cyd operon protein YbgT
PF364_10805	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
PF364_10815	COG0552	protein localization to endoplasmic reticulum
PF364_10840	COG0517	IMP dehydrogenase activity
PF364_10840	COG0516	GMP reductase activity
PF364_10845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF364_10850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PF364_10860	COG0583	DNA-binding transcription factor activity
PF364_10865	COG0024	Methionine aminopeptidase
PF364_10895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PF364_10895	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF364_10900	COG1105	Belongs to the carbohydrate kinase PfkB family
PF364_10905	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PF364_10905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF364_10905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF364_10925	COG5001	Diguanylate cyclase
PF364_10925	COG3300	MHYT domain
PF364_10940	COG2135	peptidase activity
PF364_10945	COG0659	secondary active sulfate transmembrane transporter activity
PF364_10965	COG1113	amino acid transport
PF364_10975	COG1522	sequence-specific DNA binding
PF364_11000	COG1011	Hydrolase
PF364_11005	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PF364_11015	COG2137	regulation of response to DNA damage stimulus
PF364_11030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF364_11050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PF364_11065	COG0575	Belongs to the CDS family
PF364_11070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PF364_11090	COG3852	Histidine kinase
PF364_11095	COG2204	response regulator
PF364_11150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF364_11155	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PF364_11175	COG0697	spore germination
PF364_11180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF364_11195	COG0521	Mo-molybdopterin cofactor biosynthetic process
PF364_11195	COG0315	cyclic pyranopterin monophosphate synthase activity
PF364_11215	COG0243	molybdopterin cofactor binding
PF364_11225	COG0243	molybdopterin cofactor binding
PF364_11230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF364_11235	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF364_11235	COG2146	nitrite reductase [NAD(P)H] activity
PF364_11245	COG0745	RESPONSE REGULATOR receiver
PF364_11250	COG1116	anion transmembrane transporter activity
PF364_11250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF364_11270	COG0511	ligase activity, forming carbon-carbon bonds
PF364_11285	COG2814	Major facilitator Superfamily
PF364_11305	COG3179	chitinase
PF364_11455	COG5410	chromosome segregation
PF364_11495	COG3617	BRO family, N-terminal domain
PF364_11655	COG0069	glutamate synthase activity
PF364_11675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF364_11685	COG1454	alcohol dehydrogenase
PF364_11690	COG0824	Thioesterase
PF364_11700	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PF364_11715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF364_11720	COG2030	dehydratase
PF364_11730	COG0183	Belongs to the thiolase family
PF364_11740	COG0583	DNA-binding transcription factor activity
PF364_11745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PF364_11755	COG1522	sequence-specific DNA binding
PF364_11760	COG3135	benzoate transporter
PF364_11770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PF364_11795	COG0589	response to stress
PF364_11800	COG0488	(ABC) transporter
PF364_11820	COG4773	Receptor
PF364_11850	COG0668	transmembrane transport
PF364_11860	COG1309	transcriptional regulator
PF364_11880	COG1605	Chorismate mutase
PF364_11900	COG0308	aminopeptidase N
PF364_11920	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
PF364_11930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF364_11935	COG1454	alcohol dehydrogenase
PF364_11955	COG0531	amino acid
PF364_11960	COG4303	Ethanolamine ammonia lyase large subunit
PF364_11965	COG4302	ethanolamine ammonia-lyase activity
PF364_11970	COG0519	Catalyzes the synthesis of GMP from XMP
PF364_11970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF364_11975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF364_12000	COG0697	spore germination
PF364_12005	COG1923	regulation of RNA biosynthetic process
PF364_12015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PF364_12020	COG0802	atpase or kinase
PF364_12040	COG1187	pseudouridine synthase activity
PF364_12055	COG0583	DNA-binding transcription factor activity
PF364_12070	COG2814	Major facilitator Superfamily
PF364_12075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF364_12100	COG0729	surface antigen
PF364_12120	COG0174	glutamine synthetase
PF364_12125	COG0745	RESPONSE REGULATOR receiver
PF364_12130	COG2205	protein histidine kinase activity
PF364_12140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
PF364_12145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PF364_12155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PF364_12170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF364_12175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF364_12180	COG1960	acyl-CoA dehydrogenase activity
PF364_12195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF364_12200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF364_12220	COG0583	DNA-binding transcription factor activity
PF364_12235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF364_12245	COG3658	cytochrome
PF364_12250	COG1215	transferase activity, transferring glycosyl groups
PF364_12255	COG0726	polysaccharide deacetylase
PF364_12255	COG1649	PFAM Uncharacterised BCR, COG1649
PF364_12280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF364_12285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF364_12295	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PF364_12320	COG0305	Participates in initiation and elongation during chromosome replication
PF364_12325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF364_12335	COG1305	Transglutaminase-like
PF364_12345	COG2308	Evidence 4 Homologs of previously reported genes of
PF364_12375	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PF364_12380	COG0138	bifunctional purine biosynthesis protein purh
PF364_12385	COG0151	Belongs to the GarS family
PF364_12390	COG1464	Belongs to the NlpA lipoprotein family
PF364_12395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF364_12400	COG2011	ABC-type metal ion transport system permease component
PF364_12405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF364_12415	COG1301	dicarboxylic acid transport
PF364_12445	COG1794	racemase activity, acting on amino acids and derivatives
PF364_12455	COG3008	intermembrane lipid transfer
PF364_12455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PF364_12460	COG2995	paraquat-inducible protein a
PF364_12490	COG0477	Major facilitator Superfamily
PF364_12500	COG2186	Transcriptional regulator
PF364_12510	COG0786	glutamate:sodium symporter activity
PF364_12515	COG3243	poly(R)-hydroxyalkanoic acid synthase
PF364_12540	COG3111	PFAM Bacterial OB fold (BOF) protein
PF364_12610	COG0515	serine threonine protein kinase
PF364_12610	COG2815	serine threonine protein kinase
PF364_12640	COG1610	YqeY-like protein
PF364_12645	COG4783	chaperone-mediated protein folding
PF364_12670	COG1286	toxin biosynthetic process
PF364_12700	COG0778	Nitroreductase
PF364_12710	COG0513	Belongs to the DEAD box helicase family
PF364_12735	COG2363	Small membrane protein
PF364_12765	COG4650	regulator
PF364_12770	COG1234	tRNA 3'-trailer cleavage
PF364_12775	COG1690	Belongs to the RtcB family
PF364_12795	COG2195	Cleaves the N-terminal amino acid of tripeptides
PF364_12815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PF364_12825	COG2819	hydrolase of the alpha beta superfamily
PF364_12830	COG1960	acyl-CoA dehydrogenase activity
PF364_12835	COG1301	dicarboxylic acid transport
PF364_12845	COG3139	Protein of unknown function (DUF1315)
PF364_12850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF364_12855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF364_12865	COG0494	nUDIX hydrolase
PF364_12875	COG0642	Histidine kinase
PF364_12890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PF364_12900	COG1720	tRNA m6t6A37 methyltransferase activity
PF364_12915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF364_12920	COG0826	peptidase U32
PF364_12925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF364_12935	COG4598	ABC transporter
PF364_12940	COG4160	amino acid transport
PF364_12945	COG4215	(ABC) transporter
PF364_12960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF364_13005	COG1131	(ABC) transporter
PF364_13010	COG0842	Transport permease protein
PF364_13025	COG0772	Belongs to the SEDS family
PF364_13030	COG2951	lytic endotransglycosylase activity
PF364_13055	COG2207	Transcriptional regulator
PF364_13070	COG0052	Belongs to the universal ribosomal protein uS2 family
PF364_13075	COG0024	Methionine aminopeptidase
PF364_13085	COG2223	nitrite transmembrane transporter activity
PF364_13095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF364_13100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF364_13105	COG1960	acyl-CoA dehydrogenase activity
PF364_13120	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PF364_13125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PF364_13130	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF364_13150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF364_13155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PF364_13160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF364_13195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PF364_13205	COG0174	glutamine synthetase
PF364_13220	COG0512	Glutamine amidotransferase of anthranilate synthase
PF364_13225	COG0308	aminopeptidase N
PF364_13255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PF364_13265	COG0302	gtp cyclohydrolase
PF364_13285	COG3739	integral membrane protein
PF364_13305	COG2977	Belongs to the P-Pant transferase superfamily
PF364_13310	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
PF364_13315	COG1132	(ABC) transporter
PF364_13320	COG1132	(ABC) transporter
PF364_13335	COG1535	isochorismatase
PF364_13335	COG3433	isochorismatase activity
PF364_13340	COG1021	2,3-dihydroxybenzoate-AMP ligase
PF364_13345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF364_13355	COG4774	siderophore transport
PF364_13360	COG4607	ABC-type enterochelin transport system periplasmic component
PF364_13365	COG4604	ABC transporter, ATP-binding protein
PF364_13370	COG4605	iron ion homeostasis
PF364_13375	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF364_13385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF364_13400	COG2964	Protein conserved in bacteria
PF364_13410	COG1741	Belongs to the pirin family
PF364_13450	COG2130	NADP-dependent
PF364_13460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF364_13470	COG0596	Alpha beta hydrolase
PF364_13485	COG0583	DNA-binding transcription factor activity
PF364_13490	COG1335	isochorismatase
PF364_13530	COG2879	small protein
PF364_13535	COG1966	Carbon starvation protein
PF364_13555	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PF364_13580	COG1067	ATP-dependent peptidase activity
PF364_13585	COG0583	DNA-binding transcription factor activity
PF364_13610	COG1686	Belongs to the peptidase S11 family
PF364_13615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PF364_13650	COG0616	signal peptide processing
PF364_13655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF364_13665	COG0573	inorganic phosphate transmembrane transporter activity
PF364_13670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PF364_13675	COG1113	amino acid transport
PF364_13680	COG3961	Belongs to the TPP enzyme family
PF364_13685	COG1522	sequence-specific DNA binding
PF364_13695	COG0076	glutamate decarboxylase activity
PF364_13700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF364_13710	COG1309	transcriptional regulator
PF364_13725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF364_13760	COG0352	thiamine-phosphate diphosphorylase activity
PF364_13785	COG0612	Peptidase, M16
PF364_13795	COG1823	symporter activity
PF364_13800	COG0583	DNA-binding transcription factor activity
PF364_13805	COG0477	Major facilitator Superfamily
PF364_13830	COG1187	pseudouridine synthase activity
PF364_13845	COG1686	Belongs to the peptidase S11 family
PF364_13850	COG1252	NADH dehydrogenase
PF364_13865	COG2070	2-Nitropropane dioxygenase
PF364_13920	COG0556	nucleotide-excision repair
PF364_13940	COG0436	Aminotransferase
PF364_13950	COG0443	Heat shock 70 kDa protein
PF364_13980	COG4221	oxidoreductase activity
PF364_13990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PF364_13995	COG1381	Involved in DNA repair and RecF pathway recombination
PF364_14005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PF364_14020	COG0681	Belongs to the peptidase S26 family
PF364_14030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF364_14040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF364_14060	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF364_14065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF364_14070	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PF364_14080	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PF364_14085	COG4208	sulfate ABC transporter
PF364_14090	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PF364_14095	COG0583	DNA-binding transcription factor activity
PF364_14100	COG4625	pathogenesis
PF364_14115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PF364_14130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PF364_14140	COG1056	cytidyltransferase-related domain
PF364_14140	COG1051	belongs to the nudix hydrolase family
PF364_14145	COG1024	Enoyl-CoA hydratase
PF364_14160	COG2814	Major facilitator Superfamily
PF364_14165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PF364_14165	COG0047	phosphoribosylformylglycinamidine synthase activity
PF364_14185	COG1473	amidohydrolase
PF364_14190	COG0824	Thioesterase
PF364_14210	COG0823	Involved in the tonB-independent uptake of proteins
PF364_14230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF364_14265	COG0628	permease
PF364_14275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PF364_14280	COG0596	Alpha beta hydrolase
PF364_14285	COG0616	signal peptide processing
PF364_14285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PF364_14295	COG0658	competence protein
PF364_14295	COG2333	competence protein COMEC
PF364_14300	COG1136	(ABC) transporter
PF364_14305	COG4591	ABC-type transport system involved in lipoprotein release permease component
PF364_14340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF364_14360	COG0463	Glycosyl transferase, family 2
PF364_14390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PF364_14395	COG1280	lysine exporter protein (LysE YggA)
PF364_14400	COG2267	carboxylic ester hydrolase activity
PF364_14410	COG0019	diaminopimelate decarboxylase activity
PF364_14420	COG1113	amino acid transport
PF364_14435	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PF364_14445	COG3339	Conserved Protein
PF364_14450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PF364_14455	COG0243	molybdopterin cofactor binding
PF364_14460	COG1929	Belongs to the glycerate kinase type-1 family
PF364_14475	COG0778	Nitroreductase
PF364_14500	COG3811	Belongs to the UPF0386 family
PF364_14525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF364_14540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PF364_14560	COG0741	lytic transglycosylase activity
PF364_14580	COG0584	glycerophosphoryl diester phosphodiesterase
PF364_14585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF364_14610	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF364_14615	COG1597	lipid kinase activity
PF364_14630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PF364_14635	COG0477	Major facilitator Superfamily
PF364_14685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PF364_14690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF364_14715	COG0505	Belongs to the CarA family
PF364_14735	COG0589	response to stress
PF364_14750	COG2843	Capsule synthesis protein
PF364_14770	COG2321	neutral zinc metallopeptidase
PF364_14775	COG2354	Protein conserved in bacteria
PF364_14795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF364_14820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PF364_14825	COG1053	succinate dehydrogenase
PF364_14830	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PF364_14835	COG2009	succinate dehydrogenase
PF364_14870	COG2921	Belongs to the UPF0250 family
PF364_14875	COG0321	lipoyl(octanoyl) transferase activity
PF364_14890	COG0531	amino acid
PF364_14900	COG1733	regulation of RNA biosynthetic process
PF364_14905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PF364_14910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF364_14910	COG1648	precorrin-2 dehydrogenase activity
PF364_14925	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PF364_14955	COG0671	phosphoesterase, PA-phosphatase related
PF364_14960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF364_14970	COG1538	Outer membrane efflux protein
PF364_14975	COG0393	Putative heavy-metal-binding
PF364_14980	COG0393	Putative heavy-metal-binding
PF364_14990	COG1028	Short-chain dehydrogenase reductase Sdr
PF364_15000	COG0525	valine-tRNA ligase activity
PF364_15020	COG0583	DNA-binding transcription factor activity
PF364_15025	COG0004	ammonium transporteR
PF364_15040	COG0642	Histidine kinase
PF364_15045	COG0745	RESPONSE REGULATOR receiver
PF364_15050	COG2194	sulfuric ester hydrolase activity
PF364_15070	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF364_15085	COG2315	Protein conserved in bacteria
PF364_15090	COG0142	geranyltranstransferase activity
PF364_15095	COG2828	Protein conserved in bacteria
PF364_15100	COG1113	amino acid transport
PF364_15235	COG0740	serine-type endopeptidase activity
PF364_15240	COG4695	Portal protein
PF364_15245	COG4626	Terminase
PF364_15245	COG1802	Transcriptional regulator
PF364_15290	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
PF364_15310	COG0305	Participates in initiation and elongation during chromosome replication
PF364_15345	COG4197	protein conserved in bacteria, prophage-related
PF364_15350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PF364_15415	COG2207	Transcriptional regulator
PF364_15450	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF364_15460	COG0560	Phosphoserine phosphatase
PF364_15470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF364_15480	COG1530	ribonuclease E activity
PF364_15485	COG0424	maF-like protein
PF364_15490	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PF364_15495	COG1792	Involved in formation and maintenance of cell shape
PF364_15500	COG1077	Cell shape determining protein MreB Mrl
PF364_15505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF364_15515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF364_15540	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
PF364_15545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF364_15550	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF364_15580	COG2814	Major facilitator Superfamily
PF364_15585	COG1289	transmembrane transporter activity
PF364_15595	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF364_15635	COG1376	ErfK ybiS ycfS ynhG family protein
PF364_15640	COG2832	Protein of unknown function (DUF454)
PF364_15650	COG5510	response to toxic substance
PF364_15675	COG0840	transmembrane signaling receptor activity
PF364_15715	COG3422	double-strand break repair
PF364_15720	COG2824	Alkylphosphonate utilization operon protein PhnA
PF364_15725	COG3189	MarR family transcriptional regulator
PF364_15735	COG0354	folic acid binding
PF364_15740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF364_15750	COG0679	Auxin Efflux Carrier
PF364_15755	COG1902	pentaerythritol trinitrate reductase activity
PF364_15760	COG4772	TonB-dependent receptor
PF364_15765	COG2094	Belongs to the DNA glycosylase MPG family
PF364_15790	COG1217	gtp-binding protein TYPA
PF364_15795	COG2233	PERMEase
PF364_15805	COG0833	amino acid
PF364_15810	COG1690	Belongs to the RtcB family
PF364_15820	COG2885	chlorophyll binding
PF364_15820	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PF364_15830	COG0183	Belongs to the thiolase family
PF364_15850	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF364_15870	COG2207	Transcriptional regulator
PF364_15875	COG0183	Belongs to the thiolase family
PF364_15905	COG1272	protein, Hemolysin III
PF364_15910	COG0477	Major facilitator Superfamily
PF364_15925	COG0450	alkyl hydroperoxide reductase
PF364_15945	COG0285	dihydrofolate synthase activity
PF364_15995	COG2096	Adenosyltransferase
PF364_16000	COG0584	glycerophosphoryl diester phosphodiesterase
PF364_16015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PF364_16020	COG0745	RESPONSE REGULATOR receiver
PF364_16025	COG2205	protein histidine kinase activity
PF364_16035	COG1960	acyl-CoA dehydrogenase activity
PF364_16040	COG1960	acyl-CoA dehydrogenase activity
PF364_16115	COG0438	transferase activity, transferring glycosyl groups
PF364_16120	COG0463	Glycosyl transferase, family 2
PF364_16125	COG0726	polysaccharide deacetylase
PF364_16145	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PF364_16150	COG2205	protein histidine kinase activity
PF364_16180	COG1862	Preprotein translocase
PF364_16190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF364_16195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PF364_16205	COG3781	membrane
PF364_16210	COG0613	PHP domain protein
PF364_16220	COG2350	Protein conserved in bacteria
PF364_16250	COG1607	acyl-coa hydrolase
PF364_16310	COG2199	diguanylate cyclase activity
PF364_16320	COG1408	metallophosphoesterase
PF364_16325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF364_16335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PF364_16355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PF364_16360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PF364_16365	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PF364_16375	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PF364_16385	COG2969	positive regulation of protein catabolic process
PF364_16405	COG1960	acyl-CoA dehydrogenase activity
PF364_16410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF364_16425	COG1309	transcriptional regulator
PF364_16430	COG1960	acyl-CoA dehydrogenase activity
PF364_16475	COG1183	phosphatidylcholine synthase activity
PF364_16480	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PF364_16510	COG0741	lytic transglycosylase activity
PF364_16510	COG1196	nuclear chromosome segregation
PF364_16510	COG0739	heme binding
PF364_16520	COG1702	phosphate starvation-inducible protein PhoH
PF364_16555	COG1295	ribonuclease BN
PF364_16560	COG0697	spore germination
PF364_16565	COG2169	Transcriptional regulator
PF364_16570	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF364_16615	COG0557	exoribonuclease II activity
PF364_16620	COG0339	signal peptide processing
PF364_16625	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PF364_16655	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PF364_16660	COG1960	acyl-CoA dehydrogenase activity
PF364_16815	COG0626	cystathionine gamma-synthase activity
PF364_16820	COG0433	COG0433 Predicted ATPase
PF364_16825	COG1017	nitric oxide dioxygenase activity
PF364_16825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF364_16830	COG1959	2 iron, 2 sulfur cluster binding
PF364_16845	COG1301	dicarboxylic acid transport
PF364_16850	COG1946	Acyl-CoA thioesterase
PF364_16870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PF364_16875	COG1040	competence protein
PF364_16880	COG0494	nUDIX hydrolase
PF364_16890	COG0598	Magnesium transport protein CorA
PF364_16900	COG2854	intermembrane phospholipid transfer
PF364_16910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PF364_16915	COG1127	ABC transporter
PF364_16925	COG0513	Belongs to the DEAD box helicase family
PF364_16945	COG0408	coproporphyrinogen oxidase activity
PF364_16960	COG1960	acyl-CoA dehydrogenase activity
PF364_16970	COG1983	PspC domain protein
PF364_16975	COG0517	IMP dehydrogenase activity
PF364_17000	COG0752	glycyl-tRNA synthetase alpha subunit
PF364_17025	COG0583	DNA-binding transcription factor activity
PF364_17065	COG1012	belongs to the aldehyde dehydrogenase family
PF364_17075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF364_17080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF364_17085	COG0833	amino acid
PF364_17115	COG1192	Involved in chromosome partitioning
PF364_17120	COG0628	permease
PF364_17130	COG1289	transmembrane transporter activity
PF364_17145	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF364_17150	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF364_17160	COG0277	FAD linked oxidase domain protein
PF364_17165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF364_17195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PF364_17200	COG5380	lipid catabolic process
PF364_17220	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PF364_17275	COG0194	GDP metabolic process
PF364_17290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF364_17310	COG3307	-O-antigen
PF364_17325	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PF364_17330	COG1704	LemA family
PF364_17340	COG0493	'glutamate synthase
PF364_17345	COG0070	glutamate synthase
PF364_17345	COG0069	glutamate synthase activity
PF364_17345	COG0067	glutamate synthase
PF364_17395	COG2226	methyltransferase
PF364_17410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PF364_17415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PF364_17460	COG0833	amino acid
PF364_17525	COG0488	(ABC) transporter
PF364_17530	COG2873	o-acetylhomoserine
PF364_17535	COG4221	oxidoreductase activity
PF364_17540	COG0659	secondary active sulfate transmembrane transporter activity
PF364_17565	COG0427	acetyl-CoA hydrolase
PF364_17595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PF364_17615	COG1132	(ABC) transporter
PF364_17630	COG2329	Antibiotic biosynthesis monooxygenase
PF364_17645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF364_17710	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF364_17715	COG1733	regulation of RNA biosynthetic process
PF364_17750	COG0667	Aldo Keto reductase
PF364_17770	COG1309	transcriptional regulator
PF364_17785	COG0583	DNA-binding transcription factor activity
PF364_17790	COG2814	Major facilitator Superfamily
PF364_17825	COG1335	isochorismatase
PF364_17835	COG1012	belongs to the aldehyde dehydrogenase family
PF364_17840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF364_17850	COG1113	amino acid transport
PF364_17860	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF364_17900	COG2814	Major facilitator Superfamily
PF364_17910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF364_17910	COG0352	thiamine-phosphate diphosphorylase activity
PF364_17910	COG0351	phosphomethylpyrimidine kinase
PF364_17930	COG1309	transcriptional regulator
PF364_17935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PF364_17955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF364_17965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF364_17970	COG3162	membrane
PF364_17975	COG2198	Histidine kinase
PF364_17975	COG2205	protein histidine kinase activity
PF364_17975	COG0784	Response regulator, receiver
PF364_18000	COG1522	sequence-specific DNA binding
PF364_18005	COG1335	isochorismatase
PF364_18010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF364_18020	COG0668	transmembrane transport
PF364_18025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF364_18030	COG1519	Transferase
PF364_18035	COG1902	pentaerythritol trinitrate reductase activity
PF364_18060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PF364_18085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF364_18085	COG0426	domain, Protein
PF364_18090	COG4774	siderophore transport
PF364_18095	COG2119	membrane
PF364_18105	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF364_18115	COG4942	peptidase
PF364_18130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PF364_18140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PF364_18160	COG0189	ligase activity
PF364_18180	COG0708	Exodeoxyribonuclease III
PF364_18185	COG1393	Belongs to the ArsC family
PF364_18200	COG3706	GGDEF domain
PF364_18235	COG2351	hydroxyisourate hydrolase activity
PF364_18240	COG2233	PERMEase
PF364_18250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF364_18260	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
PF364_18270	COG3150	esterase
PF364_18295	COG2918	glutathione biosynthetic process
PF364_18310	COG2733	membrane
PF364_18315	COG0436	Aminotransferase
PF364_18415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PF364_18420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PF364_18430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PF364_18455	COG1280	lysine exporter protein (LysE YggA)
PF364_18475	COG0010	Belongs to the arginase family
PF364_18505	COG2188	Transcriptional regulator
PF364_18515	COG0523	cobalamin synthesis protein
PF364_18525	COG1113	amino acid transport
PF364_18535	COG0625	glutathione transferase activity
PF364_18555	COG1683	Conserved Protein
PF364_18560	COG0534	Mate efflux family protein
PF364_18565	COG0385	Bile acid
PF364_18570	COG1335	isochorismatase
PF364_18575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF364_18595	COG2116	formate transmembrane transporter activity
PF364_18600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PF364_18620	COG3188	usher protein
PF364_18625	COG3121	Chaperone
PF364_18635	COG2983	Belongs to the UPF0260 family
PF364_18655	COG1194	a g-specific adenine glycosylase
PF364_18670	COG2818	Glycosylase
PF364_18675	COG1064	alcohol dehydrogenase
PF364_18680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF364_18695	COG0583	DNA-binding transcription factor activity
PF364_18700	COG0656	L-ascorbic acid biosynthetic process
PF364_18705	COG2814	Major facilitator Superfamily
PF364_18740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF364_18755	COG2233	PERMEase
PF364_18795	COG0733	neurotransmitter:sodium symporter activity
PF364_18835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PF364_18840	COG0657	acetylesterase activity
PF364_18860	COG0583	DNA-binding transcription factor activity
PF364_18890	COG2951	lytic endotransglycosylase activity
PF364_18895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PF364_18910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PF364_18920	COG0671	phosphoesterase, PA-phosphatase related
PF364_18925	COG0861	Integral membrane protein TerC family
PF364_18935	COG0754	glutathionylspermidine amidase activity
PF364_18945	COG0402	S-adenosylhomocysteine deaminase activity
PF364_18960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF364_18965	COG1230	cation diffusion facilitator family transporter
PF364_18980	COG0706	membrane insertase activity
PF364_19000	COG0659	secondary active sulfate transmembrane transporter activity
PF364_19005	COG0589	response to stress
PF364_19105	COG4683	PFAM Phage derived protein Gp49-like (DUF891)