locus-tag	class	description
H0S62_00035	COG2226	methyltransferase
H0S62_00125	COG1610	YqeY-like protein
H0S62_00130	COG4783	chaperone-mediated protein folding
H0S62_00155	COG1286	toxin biosynthetic process
H0S62_00270	COG0778	Nitroreductase
H0S62_00280	COG0513	Belongs to the DEAD box helicase family
H0S62_00300	COG2363	Small membrane protein
H0S62_00350	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0S62_00360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H0S62_00375	COG1960	acyl-CoA dehydrogenase activity
H0S62_00380	COG1301	dicarboxylic acid transport
H0S62_00385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0S62_00390	COG3139	Protein of unknown function (DUF1315)
H0S62_00395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0S62_00400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0S62_00410	COG0494	nUDIX hydrolase
H0S62_00420	COG0642	Histidine kinase
H0S62_00425	COG0745	RESPONSE REGULATOR receiver
H0S62_00430	COG3111	PFAM Bacterial OB fold (BOF) protein
H0S62_00445	COG1720	tRNA m6t6A37 methyltransferase activity
H0S62_00460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S62_00470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S62_00480	COG4598	ABC transporter
H0S62_00485	COG4160	amino acid transport
H0S62_00490	COG4215	(ABC) transporter
H0S62_00505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S62_00550	COG1131	(ABC) transporter
H0S62_00555	COG0842	Transport permease protein
H0S62_00570	COG0772	Belongs to the SEDS family
H0S62_00575	COG2951	lytic endotransglycosylase activity
H0S62_00600	COG2207	Transcriptional regulator
H0S62_00615	COG0052	Belongs to the universal ribosomal protein uS2 family
H0S62_00620	COG0024	Methionine aminopeptidase
H0S62_00630	COG2223	nitrite transmembrane transporter activity
H0S62_00640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S62_00645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0S62_00650	COG1960	acyl-CoA dehydrogenase activity
H0S62_00665	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0S62_00670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0S62_00675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S62_00695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S62_00700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0S62_00705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0S62_00740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H0S62_00750	COG0174	glutamine synthetase
H0S62_00755	COG3104	oligopeptide transport
H0S62_00765	COG0512	Glutamine amidotransferase of anthranilate synthase
H0S62_00770	COG0308	aminopeptidase N
H0S62_00840	COG3739	integral membrane protein
H0S62_00870	COG5265	(ABC) transporter
H0S62_00890	COG3433	isochorismatase activity
H0S62_00890	COG1535	isochorismatase
H0S62_00895	COG1021	2,3-dihydroxybenzoate-AMP ligase
H0S62_00900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S62_00910	COG4774	siderophore transport
H0S62_00915	COG4607	ABC-type enterochelin transport system periplasmic component
H0S62_00945	COG2964	Protein conserved in bacteria
H0S62_00955	COG1741	Belongs to the pirin family
H0S62_00970	COG4214	carbohydrate transport
H0S62_00985	COG2879	small protein
H0S62_00990	COG1966	Carbon starvation protein
H0S62_01010	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H0S62_01035	COG1067	ATP-dependent peptidase activity
H0S62_01040	COG0583	DNA-binding transcription factor activity
H0S62_01065	COG1686	Belongs to the peptidase S11 family
H0S62_01070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0S62_01105	COG0616	signal peptide processing
H0S62_01110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0S62_01120	COG0573	inorganic phosphate transmembrane transporter activity
H0S62_01125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0S62_01130	COG1113	amino acid transport
H0S62_01135	COG3961	Belongs to the TPP enzyme family
H0S62_01140	COG1522	sequence-specific DNA binding
H0S62_01150	COG0076	glutamate decarboxylase activity
H0S62_01155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S62_01180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S62_01215	COG0352	thiamine-phosphate diphosphorylase activity
H0S62_01240	COG0612	Peptidase, M16
H0S62_01255	COG0583	DNA-binding transcription factor activity
H0S62_01260	COG0477	Major facilitator Superfamily
H0S62_01285	COG1187	pseudouridine synthase activity
H0S62_01300	COG1686	Belongs to the peptidase S11 family
H0S62_01305	COG1252	NADH dehydrogenase
H0S62_01315	COG0415	Belongs to the DNA photolyase family
H0S62_01335	COG1215	transferase activity, transferring glycosyl groups
H0S62_01365	COG2070	2-Nitropropane dioxygenase
H0S62_01420	COG0556	nucleotide-excision repair
H0S62_01440	COG0436	Aminotransferase
H0S62_01470	COG4221	oxidoreductase activity
H0S62_01485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0S62_01490	COG1381	Involved in DNA repair and RecF pathway recombination
H0S62_01500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0S62_01515	COG0681	Belongs to the peptidase S26 family
H0S62_01530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S62_01550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0S62_01555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0S62_01560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S62_01570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H0S62_01575	COG4208	sulfate ABC transporter
H0S62_01580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H0S62_01585	COG0583	DNA-binding transcription factor activity
H0S62_01590	COG4625	pathogenesis
H0S62_01605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0S62_01620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0S62_01630	COG1056	cytidyltransferase-related domain
H0S62_01630	COG1051	belongs to the nudix hydrolase family
H0S62_01635	COG1024	Enoyl-CoA hydratase
H0S62_01645	COG2814	Major facilitator Superfamily
H0S62_01650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0S62_01650	COG0047	phosphoribosylformylglycinamidine synthase activity
H0S62_01670	COG1473	amidohydrolase
H0S62_01675	COG0824	Thioesterase
H0S62_01695	COG0823	Involved in the tonB-independent uptake of proteins
H0S62_01715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S62_01760	COG0628	permease
H0S62_01770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0S62_01775	COG0596	Alpha beta hydrolase
H0S62_01780	COG0616	signal peptide processing
H0S62_01780	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H0S62_01790	COG0658	competence protein
H0S62_01790	COG2333	competence protein COMEC
H0S62_01795	COG1136	(ABC) transporter
H0S62_01800	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0S62_01835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S62_01855	COG0463	Glycosyl transferase, family 2
H0S62_01885	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0S62_01890	COG1280	lysine exporter protein (LysE YggA)
H0S62_01900	COG0019	diaminopimelate decarboxylase activity
H0S62_01910	COG1113	amino acid transport
H0S62_01925	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H0S62_01935	COG3339	Conserved Protein
H0S62_01940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H0S62_01945	COG0243	molybdopterin cofactor binding
H0S62_01950	COG1929	Belongs to the glycerate kinase type-1 family
H0S62_01965	COG0778	Nitroreductase
H0S62_01990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S62_02005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S62_02025	COG0741	lytic transglycosylase activity
H0S62_02045	COG0584	glycerophosphoryl diester phosphodiesterase
H0S62_02050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S62_02070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0S62_02075	COG1597	lipid kinase activity
H0S62_02090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0S62_02095	COG0477	Major facilitator Superfamily
H0S62_02165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0S62_02170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S62_02195	COG0505	Belongs to the CarA family
H0S62_02210	COG1309	transcriptional regulator
H0S62_02215	COG0251	oxidation-reduction process
H0S62_02225	COG0589	response to stress
H0S62_02240	COG2843	Capsule synthesis protein
H0S62_02250	COG2826	transposase and inactivated derivatives, IS30 family
H0S62_02270	COG2321	neutral zinc metallopeptidase
H0S62_02275	COG2354	Protein conserved in bacteria
H0S62_02295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S62_02320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0S62_02325	COG1053	succinate dehydrogenase
H0S62_02330	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H0S62_02335	COG2009	succinate dehydrogenase
H0S62_02370	COG2921	Belongs to the UPF0250 family
H0S62_02375	COG0321	lipoyl(octanoyl) transferase activity
H0S62_02390	COG0531	amino acid
H0S62_02405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0S62_02410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0S62_02410	COG1648	precorrin-2 dehydrogenase activity
H0S62_02425	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H0S62_02455	COG0671	phosphoesterase, PA-phosphatase related
H0S62_02460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S62_02470	COG1538	Outer membrane efflux protein
H0S62_02475	COG0393	Putative heavy-metal-binding
H0S62_02480	COG0393	Putative heavy-metal-binding
H0S62_02490	COG1028	Short-chain dehydrogenase reductase Sdr
H0S62_02500	COG0525	valine-tRNA ligase activity
H0S62_02530	COG0583	DNA-binding transcription factor activity
H0S62_02535	COG0004	ammonium transporteR
H0S62_02545	COG0642	Histidine kinase
H0S62_02550	COG0745	RESPONSE REGULATOR receiver
H0S62_02555	COG2194	sulfuric ester hydrolase activity
H0S62_02575	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S62_02590	COG2315	Protein conserved in bacteria
H0S62_02595	COG0142	geranyltranstransferase activity
H0S62_02600	COG2828	Protein conserved in bacteria
H0S62_02605	COG1113	amino acid transport
H0S62_02625	COG2207	Transcriptional regulator
H0S62_02650	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S62_02660	COG0560	Phosphoserine phosphatase
H0S62_02670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S62_02680	COG1530	ribonuclease E activity
H0S62_02685	COG0424	maF-like protein
H0S62_02690	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H0S62_02695	COG1792	Involved in formation and maintenance of cell shape
H0S62_02700	COG1077	Cell shape determining protein MreB Mrl
H0S62_02705	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S62_02715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S62_02750	COG3590	peptidase
H0S62_02770	COG3328	transposase activity
H0S62_02780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0S62_02785	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S62_02790	COG1115	amino acid carrier protein
H0S62_02810	COG2814	Major facilitator Superfamily
H0S62_02815	COG1289	transmembrane transporter activity
H0S62_02825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0S62_02865	COG1376	ErfK ybiS ycfS ynhG family protein
H0S62_02870	COG2832	Protein of unknown function (DUF454)
H0S62_02880	COG5510	response to toxic substance
H0S62_02925	COG0840	transmembrane signaling receptor activity
H0S62_02965	COG3422	double-strand break repair
H0S62_02970	COG2824	Alkylphosphonate utilization operon protein PhnA
H0S62_02975	COG3189	MarR family transcriptional regulator
H0S62_02980	COG0596	Alpha beta hydrolase
H0S62_02985	COG0778	Nitroreductase
H0S62_02990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S62_02995	COG1335	isochorismatase
H0S62_03000	COG0251	oxidation-reduction process
H0S62_03005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S62_03010	COG2233	PERMEase
H0S62_03025	COG0354	folic acid binding
H0S62_03030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S62_03040	COG0679	Auxin Efflux Carrier
H0S62_03045	COG1902	pentaerythritol trinitrate reductase activity
H0S62_03050	COG4772	TonB-dependent receptor
H0S62_03055	COG2094	Belongs to the DNA glycosylase MPG family
H0S62_03085	COG2233	PERMEase
H0S62_03095	COG0833	amino acid
H0S62_03100	COG1690	Belongs to the RtcB family
H0S62_03110	COG2885	chlorophyll binding
H0S62_03110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H0S62_03120	COG0183	Belongs to the thiolase family
H0S62_03140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S62_03160	COG2207	Transcriptional regulator
H0S62_03165	COG0183	Belongs to the thiolase family
H0S62_03185	COG2153	protein acetylation
H0S62_03195	COG1272	protein, Hemolysin III
H0S62_03200	COG0477	Major facilitator Superfamily
H0S62_03215	COG0450	alkyl hydroperoxide reductase
H0S62_03235	COG0285	dihydrofolate synthase activity
H0S62_03280	COG4206	TonB-dependent receptor
H0S62_03285	COG2096	Adenosyltransferase
H0S62_03290	COG0584	glycerophosphoryl diester phosphodiesterase
H0S62_03305	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H0S62_03310	COG0745	RESPONSE REGULATOR receiver
H0S62_03315	COG2205	protein histidine kinase activity
H0S62_03325	COG1960	acyl-CoA dehydrogenase activity
H0S62_03330	COG1960	acyl-CoA dehydrogenase activity
H0S62_03380	COG1215	transferase activity, transferring glycosyl groups
H0S62_03395	COG1091	dTDP-4-dehydrorhamnose reductase activity
H0S62_03410	COG0438	transferase activity, transferring glycosyl groups
H0S62_03415	COG0726	polysaccharide deacetylase
H0S62_03430	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H0S62_03435	COG2205	protein histidine kinase activity
H0S62_03445	COG3646	Phage regulatory protein
H0S62_03460	COG4695	Portal protein
H0S62_03630	COG3646	Phage regulatory protein
H0S62_03710	COG1862	Preprotein translocase
H0S62_03730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0S62_03740	COG3781	membrane
H0S62_03745	COG0613	PHP domain protein
H0S62_03755	COG2350	Protein conserved in bacteria
H0S62_03785	COG1607	acyl-coa hydrolase
H0S62_03870	COG1408	metallophosphoesterase
H0S62_03875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S62_03885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0S62_03905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0S62_03910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0S62_03925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0S62_03935	COG2969	positive regulation of protein catabolic process
H0S62_03955	COG1960	acyl-CoA dehydrogenase activity
H0S62_03960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S62_03975	COG1309	transcriptional regulator
H0S62_03985	COG1960	acyl-CoA dehydrogenase activity
H0S62_04040	COG1183	phosphatidylcholine synthase activity
H0S62_04045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H0S62_04075	COG0741	lytic transglycosylase activity
H0S62_04075	COG1196	nuclear chromosome segregation
H0S62_04075	COG0739	heme binding
H0S62_04085	COG1702	phosphate starvation-inducible protein PhoH
H0S62_04130	COG1295	ribonuclease BN
H0S62_04135	COG0697	spore germination
H0S62_04140	COG2169	Transcriptional regulator
H0S62_04145	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0S62_04170	COG3293	Transposase
H0S62_04200	COG0557	exoribonuclease II activity
H0S62_04205	COG0339	signal peptide processing
H0S62_04210	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H0S62_04230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H0S62_04235	COG1960	acyl-CoA dehydrogenase activity
H0S62_04390	COG0626	cystathionine gamma-synthase activity
H0S62_04395	COG0433	COG0433 Predicted ATPase
H0S62_04405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S62_04405	COG1017	nitric oxide dioxygenase activity
H0S62_04410	COG1959	2 iron, 2 sulfur cluster binding
H0S62_04425	COG1301	dicarboxylic acid transport
H0S62_04430	COG1946	Acyl-CoA thioesterase
H0S62_04450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0S62_04460	COG0494	nUDIX hydrolase
H0S62_04470	COG0598	Magnesium transport protein CorA
H0S62_04480	COG2854	intermembrane phospholipid transfer
H0S62_04490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0S62_04495	COG1127	ABC transporter
H0S62_04505	COG0513	Belongs to the DEAD box helicase family
H0S62_04525	COG0408	coproporphyrinogen oxidase activity
H0S62_04540	COG1960	acyl-CoA dehydrogenase activity
H0S62_04550	COG1983	PspC domain protein
H0S62_04555	COG0517	IMP dehydrogenase activity
H0S62_04605	COG0583	DNA-binding transcription factor activity
H0S62_04645	COG1012	belongs to the aldehyde dehydrogenase family
H0S62_04655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S62_04660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S62_04665	COG0833	amino acid
H0S62_04695	COG1192	Involved in chromosome partitioning
H0S62_04700	COG0628	permease
H0S62_04715	COG1289	transmembrane transporter activity
H0S62_04730	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S62_04735	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H0S62_04745	COG0277	FAD linked oxidase domain protein
H0S62_04750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0S62_04775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0S62_04780	COG5380	lipid catabolic process
H0S62_04800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0S62_04850	COG0194	GDP metabolic process
H0S62_04865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S62_04885	COG3307	-O-antigen
H0S62_04900	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H0S62_04905	COG1704	LemA family
H0S62_04915	COG0493	'glutamate synthase
H0S62_04920	COG0069	glutamate synthase activity
H0S62_04920	COG0067	glutamate synthase
H0S62_04920	COG0070	glutamate synthase
H0S62_04970	COG2226	methyltransferase
H0S62_04985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0S62_04990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0S62_05035	COG0833	amino acid
H0S62_05135	COG0488	(ABC) transporter
H0S62_05140	COG2873	o-acetylhomoserine
H0S62_05145	COG4221	oxidoreductase activity
H0S62_05150	COG0659	secondary active sulfate transmembrane transporter activity
H0S62_05160	COG0745	RESPONSE REGULATOR receiver
H0S62_05175	COG0427	acetyl-CoA hydrolase
H0S62_05205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0S62_05245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H0S62_05315	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S62_05330	COG0667	Aldo Keto reductase
H0S62_05350	COG0583	DNA-binding transcription factor activity
H0S62_05355	COG2814	Major facilitator Superfamily
H0S62_05385	COG1335	isochorismatase
H0S62_05395	COG1012	belongs to the aldehyde dehydrogenase family
H0S62_05400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S62_05410	COG1113	amino acid transport
H0S62_05420	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S62_05435	COG2814	Major facilitator Superfamily
H0S62_05450	COG0351	phosphomethylpyrimidine kinase
H0S62_05450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S62_05450	COG0352	thiamine-phosphate diphosphorylase activity
H0S62_05470	COG1309	transcriptional regulator
H0S62_05475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0S62_05480	COG3706	GGDEF domain
H0S62_05490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S62_05500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S62_05505	COG3162	membrane
H0S62_05510	COG0784	Response regulator, receiver
H0S62_05510	COG2198	Histidine kinase
H0S62_05510	COG2205	protein histidine kinase activity
H0S62_05535	COG1522	sequence-specific DNA binding
H0S62_05540	COG1335	isochorismatase
H0S62_05545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S62_05555	COG0668	transmembrane transport
H0S62_05560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S62_05565	COG1519	Transferase
H0S62_05570	COG1902	pentaerythritol trinitrate reductase activity
H0S62_05590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0S62_05615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S62_05615	COG0426	domain, Protein
H0S62_05620	COG4774	siderophore transport
H0S62_05625	COG2119	membrane
H0S62_05635	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S62_05645	COG4942	peptidase
H0S62_05660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0S62_05670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0S62_05690	COG0189	ligase activity
H0S62_05715	COG0708	Exodeoxyribonuclease III
H0S62_05720	COG1393	Belongs to the ArsC family
H0S62_05735	COG3706	GGDEF domain
H0S62_05770	COG2351	hydroxyisourate hydrolase activity
H0S62_05775	COG2233	PERMEase
H0S62_05785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S62_05795	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H0S62_05805	COG3150	esterase
H0S62_05825	COG2918	glutathione biosynthetic process
H0S62_05840	COG2733	membrane
H0S62_05845	COG0436	Aminotransferase
H0S62_05850	COG0534	Mate efflux family protein
H0S62_05900	COG0753	catalase activity
H0S62_05945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0S62_05950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0S62_05960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0S62_06015	COG0010	Belongs to the arginase family
H0S62_06045	COG2188	Transcriptional regulator
H0S62_06055	COG0523	cobalamin synthesis protein
H0S62_06065	COG1113	amino acid transport
H0S62_06075	COG0625	glutathione transferase activity
H0S62_06095	COG1683	Conserved Protein
H0S62_06100	COG0534	Mate efflux family protein
H0S62_06105	COG0385	Bile acid
H0S62_06110	COG1335	isochorismatase
H0S62_06115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S62_06135	COG2116	formate transmembrane transporter activity
H0S62_06140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0S62_06145	COG2133	pyrroloquinoline quinone binding
H0S62_06150	COG2983	Belongs to the UPF0260 family
H0S62_06170	COG1194	a g-specific adenine glycosylase
H0S62_06185	COG2818	Glycosylase
H0S62_06190	COG1064	alcohol dehydrogenase
H0S62_06195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S62_06210	COG0583	DNA-binding transcription factor activity
H0S62_06215	COG0656	L-ascorbic acid biosynthetic process
H0S62_06220	COG2814	Major facilitator Superfamily
H0S62_06255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S62_06270	COG2233	PERMEase
H0S62_06275	COG0583	DNA-binding transcription factor activity
H0S62_06310	COG0733	neurotransmitter:sodium symporter activity
H0S62_06325	COG3293	Transposase
H0S62_06365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0S62_06370	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0S62_06375	COG0596	Alpha beta hydrolase
H0S62_06400	COG0488	(ABC) transporter
H0S62_06405	COG0586	Pfam SNARE associated Golgi protein
H0S62_06415	COG0187	DNA topoisomerase II activity
H0S62_06425	COG0592	DNA-directed DNA polymerase activity
H0S62_06455	COG0706	membrane insertase activity
H0S62_06470	COG1230	cation diffusion facilitator family transporter
H0S62_06475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S62_06490	COG0402	S-adenosylhomocysteine deaminase activity
H0S62_06510	COG0861	Integral membrane protein TerC family
H0S62_06515	COG0671	phosphoesterase, PA-phosphatase related
H0S62_06530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S62_06545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0S62_06550	COG2951	lytic endotransglycosylase activity
H0S62_06615	COG3328	transposase activity
H0S62_06630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0S62_06670	COG1047	Peptidyl-prolyl cis-trans
H0S62_06680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0S62_06685	COG0196	riboflavin kinase activity
H0S62_06695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H0S62_06700	COG1309	transcriptional regulator
H0S62_06705	COG1116	anion transmembrane transporter activity
H0S62_06710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S62_06715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S62_06720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S62_06725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S62_06745	COG1028	Short-chain dehydrogenase reductase Sdr
H0S62_06750	COG0546	phosphoglycolate phosphatase activity
H0S62_06805	COG3023	N-Acetylmuramoyl-L-alanine amidase
H0S62_06810	COG0728	peptidoglycan biosynthetic process
H0S62_06835	COG1596	polysaccharide export
H0S62_06840	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0S62_06845	COG1086	Polysaccharide biosynthesis protein
H0S62_06850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0S62_06855	COG1083	cytidylyl-transferase
H0S62_06870	COG2089	acid synthase
H0S62_06900	COG1216	Glycosyl transferase, family 2
H0S62_06905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S62_06910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0S62_06925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S62_06940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S62_06950	COG2186	Transcriptional regulator
H0S62_06960	COG0277	FAD linked oxidase domain protein
H0S62_06965	COG1448	Aminotransferase
H0S62_06975	COG1802	Transcriptional regulator
H0S62_06990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H0S62_07020	COG0564	pseudouridine synthase activity
H0S62_07060	COG0251	oxidation-reduction process
H0S62_07065	COG1113	amino acid transport
H0S62_07070	COG1113	amino acid transport
H0S62_07100	COG4115	mRNA cleavage
H0S62_07110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H0S62_07120	COG3756	Protein conserved in bacteria
H0S62_07155	COG0271	Belongs to the BolA IbaG family
H0S62_07165	COG1192	Involved in chromosome partitioning
H0S62_07180	COG0586	Pfam SNARE associated Golgi protein
H0S62_07185	COG2259	Doxx family
H0S62_07190	COG4399	Belongs to the UPF0754 family
H0S62_07195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S62_07195	COG0519	Catalyzes the synthesis of GMP from XMP
H0S62_07240	COG0281	malic enzyme
H0S62_07245	COG2837	iron assimilation
H0S62_07250	COG1280	lysine exporter protein (LysE YggA)
H0S62_07255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0S62_07260	COG1121	(ABC) transporter
H0S62_07335	COG0697	spore germination
H0S62_07345	COG0758	DNA mediated transformation
H0S62_07380	COG1309	transcriptional regulator
H0S62_07415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S62_07425	COG0655	NAD(P)H dehydrogenase (quinone) activity
H0S62_07460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0S62_07470	COG0477	Major facilitator Superfamily
H0S62_07480	COG1253	flavin adenine dinucleotide binding
H0S62_07485	COG3012	SEC-C Motif Domain Protein
H0S62_07490	COG2860	membrane
H0S62_07495	COG0477	Major facilitator Superfamily
H0S62_07505	COG0318	PFAM AMP-dependent synthetase and ligase
H0S62_07520	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0S62_07535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S62_07540	COG0235	Class ii aldolase
H0S62_07545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S62_07550	COG0606	chelatase, subunit chli
H0S62_07675	COG0606	chelatase, subunit chli
H0S62_07685	COG0347	Belongs to the P(II) protein family
H0S62_07690	COG0004	ammonium transporteR
H0S62_07700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S62_07700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S62_07745	COG0795	lipopolysaccharide-transporting ATPase activity
H0S62_07750	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0S62_07755	COG0793	Belongs to the peptidase S41A family
H0S62_07770	COG2197	response regulator
H0S62_07780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0S62_07790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S62_07795	COG4974	Belongs to the 'phage' integrase family
H0S62_07820	COG0772	Belongs to the SEDS family
H0S62_07825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S62_07830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0S62_07835	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0S62_07860	COG0697	spore germination
H0S62_07865	COG1538	Outer membrane efflux protein
H0S62_07905	COG0181	hydroxymethylbilane synthase activity
H0S62_07950	COG1716	ATPase activity
H0S62_07955	COG0546	phosphoglycolate phosphatase activity
H0S62_08050	COG0596	Alpha beta hydrolase
H0S62_08055	COG2056	Na+-H+ antiporter family
H0S62_08070	COG0326	Molecular chaperone. Has ATPase activity
H0S62_08085	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0S62_08145	COG3328	transposase activity
H0S62_08155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0S62_08160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S62_08160	COG2169	Transcriptional regulator
H0S62_08190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0S62_08200	COG0497	DNA recombination
H0S62_08215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S62_08225	COG0237	dephospho-CoA kinase activity
H0S62_08275	COG0195	Participates in both transcription termination and antitermination
H0S62_08295	COG2212	antiporter activity
H0S62_08305	COG0651	ATP synthesis coupled electron transport
H0S62_08310	COG1006	Multisubunit Na H antiporter MnhC subunit
H0S62_08315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S62_08315	COG2111	Na H antiporter
H0S62_08330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0S62_08335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S62_08350	COG2226	methyltransferase
H0S62_08370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0S62_08375	COG1074	ATP-dependent DNA helicase activity
H0S62_08380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S62_08400	COG0598	Magnesium transport protein CorA
H0S62_08405	COG0789	Transcriptional regulator
H0S62_08410	COG0484	heat shock protein binding
H0S62_08425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S62_08425	COG0475	glutathione-regulated potassium exporter activity
H0S62_08430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0S62_08450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S62_08460	COG4535	Mg2 and Co2 transporter CorC
H0S62_08465	COG0425	Belongs to the sulfur carrier protein TusA family
H0S62_08470	COG0644	oxidoreductase
H0S62_08470	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H0S62_08480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0S62_08495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S62_08500	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H0S62_08540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S62_08555	COG0534	Mate efflux family protein
H0S62_08565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0S62_08595	COG0318	PFAM AMP-dependent synthetase and ligase
H0S62_08600	COG1530	ribonuclease E activity
H0S62_08610	COG0546	phosphoglycolate phosphatase activity
H0S62_08615	COG2378	regulation of single-species biofilm formation
H0S62_08620	COG0625	glutathione transferase activity
H0S62_08630	COG0583	DNA-binding transcription factor activity
H0S62_08685	COG0473	3-isopropylmalate dehydrogenase activity
H0S62_08755	COG1301	dicarboxylic acid transport
H0S62_08765	COG1560	Kdo2-lipid A biosynthetic process
H0S62_08770	COG1280	lysine exporter protein (LysE YggA)
H0S62_08780	COG2900	Belongs to the SlyX family
H0S62_08790	COG1733	regulation of RNA biosynthetic process
H0S62_08815	COG0210	DNA helicase
H0S62_08820	COG0724	RNA recognition motif
H0S62_08840	COG4651	solute:proton antiporter activity
H0S62_08840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S62_08865	COG0788	formyltetrahydrofolate deformylase activity
H0S62_08980	COG2813	Specifically methylates the guanine in position
H0S62_08980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S62_08990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0S62_09000	COG4774	siderophore transport
H0S62_09010	COG0740	serine-type endopeptidase activity
H0S62_09030	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S62_09030	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S62_09035	COG0857	belongs to the CobB CobQ family
H0S62_09035	COG0280	phosphate acetyltransferase
H0S62_09040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0S62_09050	COG0800	Aldolase
H0S62_09060	COG3265	gluconokinase activity
H0S62_09065	COG1012	belongs to the aldehyde dehydrogenase family
H0S62_09075	COG2267	carboxylic ester hydrolase activity
H0S62_09090	COG0793	Belongs to the peptidase S41A family
H0S62_09125	COG1426	Protein conserved in bacteria
H0S62_09165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0S62_09175	COG1162	GTPase activity
H0S62_09180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H0S62_09195	COG1538	Outer membrane efflux protein
H0S62_09200	COG1136	(ABC) transporter
H0S62_09200	COG0577	efflux transmembrane transporter activity
H0S62_09205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S62_09230	COG0028	Belongs to the TPP enzyme family
H0S62_09235	COG0440	acetolactate synthase activity
H0S62_09275	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0S62_09290	COG0084	hydrolase, TatD family'
H0S62_09300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0S62_09310	COG0583	DNA-binding transcription factor activity
H0S62_09320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0S62_09325	COG2814	Major facilitator Superfamily
H0S62_09335	COG0697	spore germination
H0S62_09365	COG3622	Belongs to the hyi family
H0S62_09370	COG2084	Dehydrogenase
H0S62_09375	COG1024	Enoyl-CoA hydratase
H0S62_09380	COG0784	Response regulator, receiver
H0S62_09380	COG5002	protein histidine kinase activity
H0S62_09380	COG2205	protein histidine kinase activity
H0S62_09400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S62_09410	COG3956	TIGRFAM MazG family protein
H0S62_09420	COG0617	tRNA 3'-terminal CCA addition
H0S62_09425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0S62_09445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0S62_09450	COG3028	Belongs to the UPF0307 family
H0S62_09455	COG0318	PFAM AMP-dependent synthetase and ligase
H0S62_09470	COG0625	glutathione transferase activity
H0S62_09475	COG1238	metal cluster binding
H0S62_09525	COG0072	phenylalanine-tRNA ligase activity
H0S62_09555	COG0248	Ppx GppA phosphatase
H0S62_09565	COG0037	tRNA processing
H0S62_09605	COG1764	response to oxidative stress
H0S62_09610	COG1846	Transcriptional regulator
H0S62_09620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S62_09680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H0S62_09685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0S62_09690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0S62_09700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0S62_09710	COG3328	transposase activity
H0S62_09730	COG1214	PFAM Peptidase M22, glycoprotease
H0S62_09745	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H0S62_09755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0S62_09760	COG0561	phosphatase activity
H0S62_09770	COG2132	Multicopper oxidase
H0S62_09775	COG3667	copper resistance
H0S62_09790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S62_09795	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H0S62_09800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H0S62_09835	COG4695	Portal protein
H0S62_09880	COG3409	Peptidoglycan-binding domain 1 protein
H0S62_09880	COG0860	N-Acetylmuramoyl-L-alanine amidase
H0S62_10090	COG0582	viral genome integration into host DNA
H0S62_10105	COG1063	alcohol dehydrogenase
H0S62_10120	COG0583	DNA-binding transcription factor activity
H0S62_10130	COG0583	DNA-binding transcription factor activity
H0S62_10145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S62_10160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0S62_10180	COG0745	RESPONSE REGULATOR receiver
H0S62_10185	COG2205	protein histidine kinase activity
H0S62_10195	COG3706	GGDEF domain
H0S62_10220	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H0S62_10250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S62_10255	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S62_10275	COG0583	DNA-binding transcription factor activity
H0S62_10295	COG0668	transmembrane transport
H0S62_10305	COG2081	HI0933 family
H0S62_10310	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0S62_10340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S62_10340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S62_10350	COG0489	protein tyrosine kinase activity
H0S62_10400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0S62_10410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0S62_10425	COG0730	response to heat
H0S62_10435	COG1196	nuclear chromosome segregation
H0S62_10455	COG2223	nitrite transmembrane transporter activity
H0S62_10460	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H0S62_10465	COG1877	trehalose-phosphatase activity
H0S62_10470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S62_10470	COG2226	methyltransferase
H0S62_10470	COG0596	Alpha beta hydrolase
H0S62_10485	COG4106	trans-aconitate 2-methyltransferase activity
H0S62_10505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H0S62_10510	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H0S62_10515	COG0009	L-threonylcarbamoyladenylate synthase
H0S62_10520	COG3101	peptidyl-lysine hydroxylation
H0S62_10525	COG1399	metal-binding, possibly nucleic acid-binding protein
H0S62_10550	COG1652	LysM domain
H0S62_10555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S62_10555	COG0351	phosphomethylpyrimidine kinase
H0S62_10555	COG0352	thiamine-phosphate diphosphorylase activity
H0S62_10575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0S62_10615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S62_10645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H0S62_10660	COG0358	DNA primase activity
H0S62_10670	COG0564	pseudouridine synthase activity
H0S62_11015	COG0582	viral genome integration into host DNA
H0S62_11025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S62_11045	COG0583	DNA-binding transcription factor activity
H0S62_11050	COG0473	3-isopropylmalate dehydrogenase activity
H0S62_11070	COG1012	belongs to the aldehyde dehydrogenase family
H0S62_11105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0S62_11105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S62_11165	COG0456	acetyltransferase
H0S62_11175	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0S62_11180	COG0492	ferredoxin-NADP+ reductase activity
H0S62_11185	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H0S62_11185	COG1674	ftsk spoiiie
H0S62_11190	COG1280	lysine exporter protein (LysE YggA)
H0S62_11205	COG2894	cell division
H0S62_11220	COG0204	Acyl-transferase
H0S62_11225	COG2885	chlorophyll binding
H0S62_11230	COG0210	DNA helicase
H0S62_11240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S62_11255	COG0121	glutamine amidotransferase
H0S62_11275	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S62_11280	COG0735	belongs to the Fur family
H0S62_11305	COG0420	3'-5' exonuclease activity
H0S62_11325	COG1090	epimerase
H0S62_11340	COG2050	protein possibly involved in aromatic compounds catabolism
H0S62_11350	COG2814	Major facilitator Superfamily
H0S62_11355	COG0405	Gamma-glutamyltransferase
H0S62_11365	COG0582	viral genome integration into host DNA
H0S62_11445	COG0477	Major facilitator Superfamily
H0S62_11450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S62_11475	COG0531	amino acid
H0S62_11480	COG2040	homocysteine
H0S62_11505	COG1309	transcriptional regulator
H0S62_11510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S62_11515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S62_11525	COG1607	acyl-coa hydrolase
H0S62_11535	COG0523	cobalamin synthesis protein
H0S62_11555	COG4681	YaeQ
H0S62_11565	COG1649	PFAM Uncharacterised BCR, COG1649
H0S62_11565	COG0726	polysaccharide deacetylase
H0S62_11570	COG1215	transferase activity, transferring glycosyl groups
H0S62_11580	COG1024	Enoyl-CoA hydratase
H0S62_11595	COG1414	Transcriptional regulator
H0S62_11615	COG1028	Short-chain dehydrogenase reductase Sdr
H0S62_11625	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S62_11630	COG2271	Major facilitator Superfamily
H0S62_11640	COG2267	carboxylic ester hydrolase activity
H0S62_11645	COG1028	Short-chain dehydrogenase reductase Sdr
H0S62_11660	COG0028	Belongs to the TPP enzyme family
H0S62_11670	COG0477	Major facilitator Superfamily
H0S62_11675	COG0242	peptide deformylase activity
H0S62_11680	COG2066	Belongs to the glutaminase family
H0S62_11685	COG2207	Transcriptional regulator
H0S62_11690	COG2223	nitrite transmembrane transporter activity
H0S62_11705	COG0583	DNA-binding transcription factor activity
H0S62_11710	COG1028	Short-chain dehydrogenase reductase Sdr
H0S62_11715	COG2271	Major facilitator Superfamily
H0S62_11720	COG3959	Transketolase, thiamine diphosphate binding domain
H0S62_11725	COG3958	Transketolase
H0S62_11735	COG0306	phosphate transporter
H0S62_11755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0S62_11800	COG4181	ATPase activity
H0S62_11805	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H0S62_11835	COG0583	DNA-binding transcription factor activity
H0S62_11845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S62_11850	COG1773	rubredoxin
H0S62_11900	COG2851	Citrate transporter
H0S62_11905	COG1253	flavin adenine dinucleotide binding
H0S62_11950	COG0804	urea catabolic process
H0S62_11960	COG0830	nickel cation binding
H0S62_11975	COG0742	ribosomal rna small subunit methyltransferase
H0S62_11980	COG0768	penicillin binding
H0S62_12005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0S62_12010	COG2878	Part of a membrane complex involved in electron transport
H0S62_12015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S62_12025	COG3384	dioxygenase
H0S62_12045	COG3328	transposase activity
H0S62_12060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0S62_12115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S62_12200	COG1484	DNA-dependent DNA replication
H0S62_12410	COG0592	DNA-directed DNA polymerase activity
H0S62_12485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0S62_12530	COG0006	proline dipeptidase activity
H0S62_12535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S62_12540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S62_12560	COG1279	arginine transmembrane transporter activity
H0S62_12565	COG0583	DNA-binding transcription factor activity
H0S62_12605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S62_12610	COG0741	lytic transglycosylase activity
H0S62_12610	COG0741	lytic transglycosylase activity
H0S62_12610	COG1388	LysM domain
H0S62_12610	COG1388	LysM domain
H0S62_12620	COG4174	ABC transporter (Permease)
H0S62_12625	COG4239	(ABC) transporter, permease
H0S62_12630	COG4172	Belongs to the ABC transporter superfamily
H0S62_12650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S62_12660	COG4251	negative regulation of phosphorylation
H0S62_12660	COG3706	GGDEF domain
H0S62_12660	COG5001	Diguanylate cyclase
H0S62_12660	COG2203	Gaf domain
H0S62_12670	COG1902	pentaerythritol trinitrate reductase activity
H0S62_12670	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S62_12685	COG4269	membrane
H0S62_12740	COG1113	amino acid transport
H0S62_12750	COG0531	amino acid
H0S62_12770	COG1012	belongs to the aldehyde dehydrogenase family
H0S62_12825	COG2252	PERMEase
H0S62_12830	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0S62_12850	COG3038	cytochrome b561
H0S62_12860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0S62_12870	COG0527	aspartate kinase activity
H0S62_12880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0S62_12890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0S62_12905	COG0667	Aldo Keto reductase
H0S62_12915	COG1765	OsmC-like protein
H0S62_12930	COG0542	response to heat
H0S62_12965	COG2885	chlorophyll binding
H0S62_12975	COG0625	glutathione transferase activity
H0S62_13005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0S62_13025	COG3634	alkyl hydroperoxide reductase activity
H0S62_13035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H0S62_13045	COG0450	alkyl hydroperoxide reductase
H0S62_13050	COG1643	Atp-dependent helicase
H0S62_13065	COG2814	Major facilitator Superfamily
H0S62_13070	COG3135	benzoate transporter
H0S62_13075	COG1028	Short-chain dehydrogenase reductase Sdr
H0S62_13080	COG0543	2 iron, 2 sulfur cluster binding
H0S62_13080	COG0633	Ferredoxin
H0S62_13085	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H0S62_13090	COG4638	Rieske (2fe-2S)
H0S62_13095	COG0583	DNA-binding transcription factor activity
H0S62_13145	COG1570	exodeoxyribonuclease VII activity
H0S62_13180	COG1280	lysine exporter protein (LysE YggA)
H0S62_13190	COG1278	Cold shock
H0S62_13230	COG3328	transposase activity
H0S62_13240	COG2814	Major facilitator Superfamily
H0S62_13280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0S62_13280	COG0517	IMP dehydrogenase activity
H0S62_13285	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0S62_13295	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H0S62_13300	COG1137	ATPase activity
H0S62_13305	COG1538	Outer membrane efflux protein
H0S62_13335	COG4122	O-methyltransferase activity
H0S62_13345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H0S62_13420	COG1560	Kdo2-lipid A biosynthetic process
H0S62_13430	COG2814	Major facilitator Superfamily
H0S62_13440	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0S62_13445	COG1116	anion transmembrane transporter activity
H0S62_13450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S62_13455	COG4521	taurine ABC transporter
H0S62_13470	COG3293	Transposase
H0S62_13485	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S62_13540	COG0583	DNA-binding transcription factor activity
H0S62_13545	COG1914	H( )-stimulated, divalent metal cation uptake system
H0S62_13565	COG4770	biotin carboxylase activity
H0S62_13570	COG0038	chloride channel
H0S62_13600	COG1063	alcohol dehydrogenase
H0S62_13615	COG3293	Transposase
H0S62_13620	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H0S62_13630	COG0789	Transcriptional regulator
H0S62_13640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S62_13660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0S62_13695	COG1012	belongs to the aldehyde dehydrogenase family
H0S62_13700	COG0531	amino acid
H0S62_13710	COG2030	dehydratase
H0S62_13710	COG1012	belongs to the aldehyde dehydrogenase family
H0S62_13715	COG3396	Phenylacetate-CoA oxygenase
H0S62_13720	COG3460	Phenylacetate-CoA oxygenase
H0S62_13725	COG3396	Phenylacetate-CoA oxygenase
H0S62_13730	COG2151	metal-sulfur cluster biosynthetic enzyme
H0S62_13735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S62_13740	COG1024	Enoyl-CoA hydratase
H0S62_13745	COG1024	Enoyl-CoA hydratase
H0S62_13755	COG0183	Belongs to the thiolase family
H0S62_13760	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H0S62_13765	COG3327	negative regulation of DNA-templated transcription, initiation
H0S62_13775	COG2050	protein possibly involved in aromatic compounds catabolism
H0S62_13790	COG0406	alpha-ribazole phosphatase activity
H0S62_13815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S62_13835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H0S62_13840	COG0531	amino acid
H0S62_13845	COG0753	catalase activity
H0S62_13850	COG3038	cytochrome b561
H0S62_13870	COG2267	carboxylic ester hydrolase activity
H0S62_13875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S62_13880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S62_13885	COG1012	belongs to the aldehyde dehydrogenase family
H0S62_13895	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H0S62_13905	COG1012	belongs to the aldehyde dehydrogenase family
H0S62_13910	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H0S62_13915	COG0583	DNA-binding transcription factor activity
H0S62_13925	COG1414	Transcriptional regulator
H0S62_13930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S62_13940	COG1840	ABC-type Fe3 transport system, periplasmic component
H0S62_13945	COG3842	ATPase activity
H0S62_13960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H0S62_13965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S62_13970	COG2814	Major facilitator Superfamily
H0S62_13975	COG1960	acyl-CoA dehydrogenase activity
H0S62_13990	COG1024	Enoyl-CoA hydratase
H0S62_14020	COG0183	Belongs to the thiolase family
H0S62_14025	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S62_14030	COG1028	Short-chain dehydrogenase reductase Sdr
H0S62_14035	COG1024	Enoyl-CoA hydratase
H0S62_14040	COG1960	acyl-CoA dehydrogenase activity
H0S62_14045	COG2814	Major facilitator Superfamily
H0S62_14050	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S62_14055	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S62_14075	COG2814	Major facilitator Superfamily
H0S62_14085	COG1960	acyl-CoA dehydrogenase activity
H0S62_14100	COG0583	DNA-binding transcription factor activity
H0S62_14115	COG4770	biotin carboxylase activity
H0S62_14120	COG1024	Enoyl-CoA hydratase
H0S62_14125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S62_14130	COG1960	acyl-CoA dehydrogenase activity
H0S62_14135	COG1309	transcriptional regulator
H0S62_14140	COG0318	PFAM AMP-dependent synthetase and ligase
H0S62_14160	COG0583	DNA-binding transcription factor activity
H0S62_14245	COG1028	Short-chain dehydrogenase reductase Sdr
H0S62_14265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H0S62_14285	COG2205	protein histidine kinase activity
H0S62_14285	COG0784	Response regulator, receiver
H0S62_14305	COG0765	amino acid transport
H0S62_14310	COG0765	amino acid transport
H0S62_14315	COG1126	abc transporter atp-binding protein
H0S62_14320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S62_14325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S62_14340	COG1280	lysine exporter protein (LysE YggA)
H0S62_14370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0S62_14375	COG1045	serine acetyltransferase
H0S62_14390	COG0583	DNA-binding transcription factor activity
H0S62_14395	COG0625	glutathione transferase activity
H0S62_14400	COG0625	glutathione transferase activity
H0S62_14405	COG0583	DNA-binding transcription factor activity
H0S62_14415	COG1346	cytolysis
H0S62_14435	COG2814	Major facilitator Superfamily
H0S62_14470	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H0S62_14475	COG3052	prosthetic group binding
H0S62_14495	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0S62_14515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S62_14525	COG1294	oxidase, subunit
H0S62_14530	COG1271	oxidase subunit
H0S62_14550	COG0477	Major facilitator Superfamily
H0S62_14560	COG4521	taurine ABC transporter
H0S62_14565	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H0S62_14570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S62_14575	COG2175	clavaminate synthase activity
H0S62_14585	COG1953	Uracil, thiamine, allantoin
H0S62_14595	COG0583	DNA-binding transcription factor activity
H0S62_14605	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H0S62_14620	COG0640	Transcriptional regulator
H0S62_14625	COG0798	PFAM Bile acid sodium symporter
H0S62_14630	COG0583	DNA-binding transcription factor activity
H0S62_14645	COG3634	alkyl hydroperoxide reductase activity
H0S62_14700	COG0436	Aminotransferase
H0S62_14710	COG0386	Belongs to the glutathione peroxidase family
H0S62_14750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S62_14775	COG0012	GTP binding
H0S62_14780	COG2011	ABC-type metal ion transport system permease component
H0S62_14785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S62_14795	COG1464	Belongs to the NlpA lipoprotein family
H0S62_14825	COG0765	amino acid transport
H0S62_14830	COG0765	amino acid transport
H0S62_14835	COG1126	abc transporter atp-binding protein
H0S62_14845	COG1522	sequence-specific DNA binding
H0S62_14920	COG3121	Chaperone
H0S62_14925	COG3539	Fimbrial protein
H0S62_14950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H0S62_14950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0S62_15005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0S62_15015	COG2353	YceI-like domain
H0S62_15025	COG3698	Phosphodiester glycosidase
H0S62_15040	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H0S62_15045	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0S62_15045	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0S62_15045	COG0506	proline dehydrogenase activity
H0S62_15055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S62_15095	COG1132	(ABC) transporter
H0S62_15100	COG3122	Protein conserved in bacteria
H0S62_15105	COG3619	membrane
H0S62_15115	COG0640	Transcriptional regulator
H0S62_15125	COG2850	peptidyl-arginine hydroxylation
H0S62_15130	COG0424	maF-like protein
H0S62_15150	COG0191	fructose-bisphosphate aldolase activity
H0S62_15155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S62_15170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H0S62_15180	COG1192	Involved in chromosome partitioning
H0S62_15185	COG1475	DNA binding
H0S62_15190	COG0811	peptide transport
H0S62_15200	COG1132	(ABC) transporter
H0S62_15205	COG1663	tetraacyldisaccharide 4'-kinase activity
H0S62_15225	COG0084	hydrolase, TatD family'
H0S62_15300	COG0776	regulation of translation
H0S62_15320	COG3328	transposase activity
H0S62_15335	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H0S62_15340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H0S62_15390	COG0339	signal peptide processing
H0S62_15400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0S62_15435	COG0702	epimerase
H0S62_15440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0S62_15460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0S62_15490	COG0316	Belongs to the HesB IscA family
H0S62_15495	COG0822	iron-sulfur transferase activity
H0S62_15520	COG0776	regulation of translation
H0S62_15525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S62_15530	COG2207	Transcriptional regulator
H0S62_15535	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S62_15540	COG1960	acyl-CoA dehydrogenase activity
H0S62_15545	COG1960	acyl-CoA dehydrogenase activity
H0S62_15560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0S62_15580	COG4264	IucA IucC family
H0S62_15585	COG4264	IucA IucC family
H0S62_15595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0S62_15625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S62_15640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H0S62_15645	COG0406	alpha-ribazole phosphatase activity
H0S62_15660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0S62_15665	COG0730	response to heat
H0S62_15685	COG4773	Receptor
H0S62_15690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S62_15705	COG1131	(ABC) transporter
H0S62_15710	COG0842	Transport permease protein
H0S62_15715	COG0842	Transport permease protein
H0S62_15770	COG2226	methyltransferase
H0S62_15805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0S62_15840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S62_15850	COG0133	tryptophan synthase activity
H0S62_15865	COG3706	GGDEF domain
H0S62_15885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H0S62_15890	COG0022	dehydrogenase e1 component
H0S62_15895	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S62_15900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S62_15910	COG1063	alcohol dehydrogenase
H0S62_15915	COG3781	membrane
H0S62_15925	COG3453	Protein conserved in bacteria
H0S62_15925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S62_15935	COG0730	response to heat
H0S62_15950	COG3708	Transcriptional regulator
H0S62_15950	COG2207	Transcriptional regulator
H0S62_15955	COG1733	regulation of RNA biosynthetic process
H0S62_15960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H0S62_15985	COG4521	taurine ABC transporter
H0S62_16000	COG0477	Major facilitator Superfamily
H0S62_16010	COG1027	Aspartate ammonia-lyase
H0S62_16025	COG0583	DNA-binding transcription factor activity
H0S62_16030	COG0583	DNA-binding transcription factor activity
H0S62_16065	COG2031	fatty acid transporter
H0S62_16080	COG0583	DNA-binding transcription factor activity
H0S62_16105	COG1309	transcriptional regulator
H0S62_16115	COG2610	gluconate transmembrane transporter activity
H0S62_16120	COG1028	Short-chain dehydrogenase reductase Sdr
H0S62_16125	COG2207	Transcriptional regulator
H0S62_16140	COG1028	Short-chain dehydrogenase reductase Sdr
H0S62_16150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S62_16165	COG0543	2 iron, 2 sulfur cluster binding
H0S62_16165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S62_16170	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H0S62_16185	COG0725	ABC transporter, periplasmic molybdate-binding protein
H0S62_16190	COG4149	molybdate abc transporter
H0S62_16195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H0S62_16200	COG1028	Short-chain dehydrogenase reductase Sdr
H0S62_16205	COG1535	isochorismatase
H0S62_16205	COG3433	isochorismatase activity
H0S62_16295	COG0753	catalase activity
H0S62_16300	COG3328	transposase activity
H0S62_16310	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H0S62_16335	COG3539	Fimbrial protein
H0S62_16375	COG2169	Transcriptional regulator
H0S62_16375	COG1917	Cupin 2, conserved barrel domain protein
H0S62_16380	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S62_16385	COG3657	addiction module killer protein
H0S62_16395	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S62_16400	COG3657	addiction module killer protein
H0S62_16425	COG2807	transmembrane transport
H0S62_16430	COG3328	transposase activity
H0S62_16445	COG3335	DDE superfamily endonuclease
H0S62_16460	COG1063	alcohol dehydrogenase
H0S62_16495	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H0S62_16510	COG1979	alcohol dehydrogenase
H0S62_16520	COG1902	pentaerythritol trinitrate reductase activity
H0S62_16530	COG1309	transcriptional regulator
H0S62_16535	COG2130	NADP-dependent
H0S62_16550	COG0697	spore germination
H0S62_16570	COG0071	Belongs to the small heat shock protein (HSP20) family
H0S62_16575	COG0542	response to heat
H0S62_16655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S62_16675	COG2826	transposase and inactivated derivatives, IS30 family
H0S62_16710	COG3328	transposase activity
H0S62_16740	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
H0S62_16750	COG2205	protein histidine kinase activity
H0S62_16770	COG2814	Major facilitator Superfamily
H0S62_16795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0S62_16890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S62_16910	COG1120	ATPase activity
H0S62_16925	COG1064	alcohol dehydrogenase
H0S62_16930	COG2207	Transcriptional regulator
H0S62_16935	COG2084	Dehydrogenase
H0S62_16945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0S62_16950	COG0583	DNA-binding transcription factor activity
H0S62_16960	COG0129	dihydroxy-acid dehydratase activity
H0S62_17030	COG0318	PFAM AMP-dependent synthetase and ligase
H0S62_17055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S62_17065	COG1028	Short-chain dehydrogenase reductase Sdr
H0S62_17075	COG4638	Rieske (2fe-2S)
H0S62_17095	COG0154	amidase activity
H0S62_17105	COG2814	Major facilitator Superfamily
H0S62_17130	COG1960	acyl-CoA dehydrogenase activity
H0S62_17135	COG0583	DNA-binding transcription factor activity
H0S62_17140	COG1414	Transcriptional regulator
H0S62_17155	COG2391	methyltransferase activity
H0S62_17160	COG3293	Transposase
H0S62_17170	COG4993	Dehydrogenase
H0S62_17175	COG3659	wide pore channel activity
H0S62_17180	COG3420	alginic acid biosynthetic process
H0S62_17185	COG0710	3-dehydroquinate dehydratase activity
H0S62_17190	COG3485	protocatechuate 3,4-dioxygenase
H0S62_17195	COG3485	protocatechuate 3,4-dioxygenase
H0S62_17200	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H0S62_17205	COG2271	Major facilitator Superfamily
H0S62_17210	COG0596	Alpha beta hydrolase
H0S62_17215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H0S62_17220	COG0183	Belongs to the thiolase family
H0S62_17225	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S62_17230	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S62_17240	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H0S62_17250	COG2323	membrane
H0S62_17295	COG1902	pentaerythritol trinitrate reductase activity
H0S62_17295	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S62_17320	COG0542	response to heat
H0S62_17325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0S62_17365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0S62_17370	COG0569	domain protein
H0S62_17375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0S62_17395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0S62_17405	COG1585	Membrane protein implicated in regulation of membrane protease activity
H0S62_17420	COG1294	oxidase, subunit
H0S62_17425	COG4890	Cyd operon protein YbgT
H0S62_17440	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H0S62_17450	COG0552	protein localization to endoplasmic reticulum
H0S62_17475	COG0517	IMP dehydrogenase activity
H0S62_17475	COG0516	GMP reductase activity
H0S62_17480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S62_17485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0S62_17495	COG0583	DNA-binding transcription factor activity
H0S62_17500	COG0024	Methionine aminopeptidase
H0S62_17530	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0S62_17530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H0S62_17535	COG1105	Belongs to the carbohydrate kinase PfkB family
H0S62_17540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0S62_17540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H0S62_17540	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H0S62_17565	COG3328	transposase activity
H0S62_17570	COG0659	secondary active sulfate transmembrane transporter activity
H0S62_17590	COG1113	amino acid transport
H0S62_17600	COG1522	sequence-specific DNA binding
H0S62_17625	COG1011	Hydrolase
H0S62_17630	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0S62_17640	COG2137	regulation of response to DNA damage stimulus
H0S62_17655	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S62_17675	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S62_17690	COG0575	Belongs to the CDS family
H0S62_17695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0S62_17720	COG3852	Histidine kinase
H0S62_17725	COG2204	response regulator
H0S62_17790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S62_17795	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H0S62_17815	COG0697	spore germination
H0S62_17820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S62_17830	COG0303	'Molybdopterin
H0S62_17835	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0S62_17835	COG0315	cyclic pyranopterin monophosphate synthase activity
H0S62_17850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0S62_17855	COG0243	molybdopterin cofactor binding
H0S62_17865	COG0243	molybdopterin cofactor binding
H0S62_17870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S62_17875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S62_17875	COG2146	nitrite reductase [NAD(P)H] activity
H0S62_17885	COG0745	RESPONSE REGULATOR receiver
H0S62_17890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S62_17890	COG1116	anion transmembrane transporter activity
H0S62_17915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0S62_17925	COG0511	ligase activity, forming carbon-carbon bonds
H0S62_17940	COG2814	Major facilitator Superfamily
H0S62_17970	COG0069	glutamate synthase activity
H0S62_17990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0S62_18000	COG1454	alcohol dehydrogenase
H0S62_18005	COG0824	Thioesterase
H0S62_18015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0S62_18035	COG2030	dehydratase
H0S62_18045	COG0183	Belongs to the thiolase family
H0S62_18055	COG0583	DNA-binding transcription factor activity
H0S62_18060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0S62_18070	COG1522	sequence-specific DNA binding
H0S62_18075	COG3135	benzoate transporter
H0S62_18110	COG0589	response to stress
H0S62_18115	COG0488	(ABC) transporter
H0S62_18135	COG4773	Receptor
H0S62_18150	COG3328	transposase activity
H0S62_18175	COG0668	transmembrane transport
H0S62_18190	COG1309	transcriptional regulator
H0S62_18210	COG1605	Chorismate mutase
H0S62_18230	COG0308	aminopeptidase N
H0S62_18250	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H0S62_18260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S62_18265	COG1454	alcohol dehydrogenase
H0S62_18285	COG0531	amino acid
H0S62_18290	COG4303	Ethanolamine ammonia lyase large subunit
H0S62_18295	COG4302	ethanolamine ammonia-lyase activity
H0S62_18300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S62_18300	COG0519	Catalyzes the synthesis of GMP from XMP
H0S62_18305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S62_18315	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S62_18330	COG0697	spore germination
H0S62_18335	COG1923	regulation of RNA biosynthetic process
H0S62_18345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0S62_18350	COG0802	atpase or kinase
H0S62_18370	COG1187	pseudouridine synthase activity
H0S62_18385	COG0583	DNA-binding transcription factor activity
H0S62_18400	COG2814	Major facilitator Superfamily
H0S62_18405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0S62_18435	COG0729	surface antigen
H0S62_18455	COG0174	glutamine synthetase
H0S62_18460	COG0745	RESPONSE REGULATOR receiver
H0S62_18465	COG2205	protein histidine kinase activity
H0S62_18475	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H0S62_18480	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H0S62_18505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S62_18510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S62_18515	COG1960	acyl-CoA dehydrogenase activity
H0S62_18530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S62_18535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S62_18550	COG3328	transposase activity
H0S62_18580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H0S62_18585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0S62_18595	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H0S62_18620	COG0305	Participates in initiation and elongation during chromosome replication
H0S62_18625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0S62_18635	COG1305	Transglutaminase-like
H0S62_18645	COG2308	Evidence 4 Homologs of previously reported genes of
H0S62_18675	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H0S62_18680	COG0138	bifunctional purine biosynthesis protein purh
H0S62_18685	COG0151	Belongs to the GarS family
H0S62_18690	COG1464	Belongs to the NlpA lipoprotein family
H0S62_18695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S62_18700	COG2011	ABC-type metal ion transport system permease component
H0S62_18705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S62_18715	COG1301	dicarboxylic acid transport
H0S62_18745	COG1794	racemase activity, acting on amino acids and derivatives
H0S62_18760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0S62_18760	COG3008	intermembrane lipid transfer
H0S62_18765	COG2995	paraquat-inducible protein a
H0S62_18795	COG0477	Major facilitator Superfamily
H0S62_18880	COG2186	Transcriptional regulator
H0S62_18890	COG0786	glutamate:sodium symporter activity
H0S62_18895	COG3243	poly(R)-hydroxyalkanoic acid synthase
H0S62_18980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S62_19000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0S62_19100	COG0515	serine threonine protein kinase
H0S62_19105	COG2116	formate transmembrane transporter activity
H0S62_19110	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H0S62_19170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S62_19260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0S62_19260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H0S62_19315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0S62_19315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0S62_19330	COG0587	DNA-directed DNA polymerase activity
H0S62_19385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0S62_19445	COG0358	DNA primase activity
H0S62_19570	COG3706	GGDEF domain
H0S62_19660	COG2337	Toxic component of a toxin-antitoxin (TA) module
H0S62_19665	COG2336	PFAM SpoVT AbrB