locus-tag	class	description
M1S35_00010	COG0592	DNA-directed DNA polymerase activity
M1S35_00020	COG0187	DNA topoisomerase II activity
M1S35_00030	COG0586	Pfam SNARE associated Golgi protein
M1S35_00035	COG0488	(ABC) transporter
M1S35_00060	COG0596	Alpha beta hydrolase
M1S35_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S35_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S35_00110	COG0733	neurotransmitter:sodium symporter activity
M1S35_00150	COG2233	PERMEase
M1S35_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S35_00200	COG2814	Major facilitator Superfamily
M1S35_00205	COG0656	L-ascorbic acid biosynthetic process
M1S35_00210	COG0583	DNA-binding transcription factor activity
M1S35_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S35_00230	COG1064	alcohol dehydrogenase
M1S35_00235	COG2818	Glycosylase
M1S35_00250	COG1194	a g-specific adenine glycosylase
M1S35_00270	COG2983	Belongs to the UPF0260 family
M1S35_00275	COG2133	pyrroloquinoline quinone binding
M1S35_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S35_00285	COG2116	formate transmembrane transporter activity
M1S35_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S35_00310	COG1335	isochorismatase
M1S35_00315	COG0385	Bile acid
M1S35_00320	COG0534	Mate efflux family protein
M1S35_00325	COG1683	Conserved Protein
M1S35_00345	COG0625	glutathione transferase activity
M1S35_00355	COG1113	amino acid transport
M1S35_00365	COG0523	cobalamin synthesis protein
M1S35_00375	COG2188	Transcriptional regulator
M1S35_00405	COG0010	Belongs to the arginase family
M1S35_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S35_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S35_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S35_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S35_00540	COG0534	Mate efflux family protein
M1S35_00545	COG0436	Aminotransferase
M1S35_00550	COG2733	membrane
M1S35_00565	COG2918	glutathione biosynthetic process
M1S35_00580	COG1388	LysM domain
M1S35_00580	COG0791	NLP P60 protein
M1S35_00595	COG3150	esterase
M1S35_00605	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S35_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S35_00630	COG2233	PERMEase
M1S35_00635	COG2351	hydroxyisourate hydrolase activity
M1S35_00670	COG3706	GGDEF domain
M1S35_00685	COG1393	Belongs to the ArsC family
M1S35_00690	COG0708	Exodeoxyribonuclease III
M1S35_00710	COG0189	ligase activity
M1S35_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S35_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S35_00755	COG4942	peptidase
M1S35_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S35_00775	COG2119	membrane
M1S35_00780	COG4774	siderophore transport
M1S35_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S35_00785	COG0426	domain, Protein
M1S35_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S35_00830	COG1902	pentaerythritol trinitrate reductase activity
M1S35_00835	COG1519	Transferase
M1S35_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S35_00845	COG0668	transmembrane transport
M1S35_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S35_00860	COG1335	isochorismatase
M1S35_00865	COG1522	sequence-specific DNA binding
M1S35_00890	COG0784	Response regulator, receiver
M1S35_00890	COG2198	Histidine kinase
M1S35_00890	COG2205	protein histidine kinase activity
M1S35_00895	COG3162	membrane
M1S35_00900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S35_00910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S35_00930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S35_00935	COG1309	transcriptional regulator
M1S35_00955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S35_00955	COG0352	thiamine-phosphate diphosphorylase activity
M1S35_00955	COG0351	phosphomethylpyrimidine kinase
M1S35_00965	COG2814	Major facilitator Superfamily
M1S35_00980	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S35_00990	COG1113	amino acid transport
M1S35_01000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S35_01005	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_01015	COG1335	isochorismatase
M1S35_01045	COG2814	Major facilitator Superfamily
M1S35_01050	COG0583	DNA-binding transcription factor activity
M1S35_01070	COG0667	Aldo Keto reductase
M1S35_01105	COG1733	regulation of RNA biosynthetic process
M1S35_01110	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S35_01175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S35_01190	COG2329	Antibiotic biosynthesis monooxygenase
M1S35_01220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S35_01250	COG0427	acetyl-CoA hydrolase
M1S35_01275	COG0659	secondary active sulfate transmembrane transporter activity
M1S35_01280	COG4221	oxidoreductase activity
M1S35_01285	COG2873	o-acetylhomoserine
M1S35_01290	COG0488	(ABC) transporter
M1S35_01375	COG0833	amino acid
M1S35_01420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S35_01425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S35_01440	COG2226	methyltransferase
M1S35_01490	COG0067	glutamate synthase
M1S35_01490	COG0069	glutamate synthase activity
M1S35_01490	COG0070	glutamate synthase
M1S35_01495	COG0493	'glutamate synthase
M1S35_01505	COG1704	LemA family
M1S35_01510	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S35_01530	COG3307	-O-antigen
M1S35_01550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S35_01565	COG0194	GDP metabolic process
M1S35_01615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S35_01635	COG5380	lipid catabolic process
M1S35_01640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S35_01665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S35_01670	COG0277	FAD linked oxidase domain protein
M1S35_01680	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S35_01685	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S35_01700	COG1289	transmembrane transporter activity
M1S35_01710	COG0628	permease
M1S35_01715	COG1192	Involved in chromosome partitioning
M1S35_01745	COG0833	amino acid
M1S35_01750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S35_01755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S35_01765	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_01805	COG0583	DNA-binding transcription factor activity
M1S35_01850	COG0517	IMP dehydrogenase activity
M1S35_01855	COG1983	PspC domain protein
M1S35_01865	COG1960	acyl-CoA dehydrogenase activity
M1S35_01880	COG0408	coproporphyrinogen oxidase activity
M1S35_01900	COG0513	Belongs to the DEAD box helicase family
M1S35_01910	COG1127	ABC transporter
M1S35_01915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S35_01925	COG2854	intermembrane phospholipid transfer
M1S35_01935	COG0598	Magnesium transport protein CorA
M1S35_01945	COG0494	nUDIX hydrolase
M1S35_01950	COG1040	competence protein
M1S35_01955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S35_01975	COG1946	Acyl-CoA thioesterase
M1S35_01980	COG1301	dicarboxylic acid transport
M1S35_01995	COG1959	2 iron, 2 sulfur cluster binding
M1S35_02000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S35_02000	COG1017	nitric oxide dioxygenase activity
M1S35_02005	COG0433	COG0433 Predicted ATPase
M1S35_02010	COG0626	cystathionine gamma-synthase activity
M1S35_02165	COG1960	acyl-CoA dehydrogenase activity
M1S35_02170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S35_02200	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S35_02205	COG0339	signal peptide processing
M1S35_02210	COG0557	exoribonuclease II activity
M1S35_02255	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S35_02260	COG2169	Transcriptional regulator
M1S35_02265	COG0697	spore germination
M1S35_02270	COG1295	ribonuclease BN
M1S35_02305	COG1702	phosphate starvation-inducible protein PhoH
M1S35_02315	COG0741	lytic transglycosylase activity
M1S35_02315	COG0739	heme binding
M1S35_02315	COG1196	nuclear chromosome segregation
M1S35_02345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S35_02350	COG1183	phosphatidylcholine synthase activity
M1S35_02395	COG1960	acyl-CoA dehydrogenase activity
M1S35_02400	COG1309	transcriptional regulator
M1S35_02415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S35_02420	COG1960	acyl-CoA dehydrogenase activity
M1S35_02440	COG2969	positive regulation of protein catabolic process
M1S35_02450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S35_02465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S35_02470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S35_02490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S35_02500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S35_02505	COG1408	metallophosphoesterase
M1S35_02515	COG2199	diguanylate cyclase activity
M1S35_02575	COG1607	acyl-coa hydrolase
M1S35_02605	COG2350	Protein conserved in bacteria
M1S35_02615	COG0613	PHP domain protein
M1S35_02620	COG3781	membrane
M1S35_02630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S35_02635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S35_02645	COG1862	Preprotein translocase
M1S35_02695	COG0629	single-stranded DNA binding
M1S35_02765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S35_02895	COG4695	Portal protein
M1S35_02925	COG2205	protein histidine kinase activity
M1S35_02930	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S35_02950	COG0726	polysaccharide deacetylase
M1S35_02955	COG0463	Glycosyl transferase, family 2
M1S35_02960	COG0438	transferase activity, transferring glycosyl groups
M1S35_03025	COG0625	glutathione transferase activity
M1S35_03030	COG0583	DNA-binding transcription factor activity
M1S35_03035	COG1960	acyl-CoA dehydrogenase activity
M1S35_03040	COG1960	acyl-CoA dehydrogenase activity
M1S35_03050	COG2205	protein histidine kinase activity
M1S35_03055	COG0745	RESPONSE REGULATOR receiver
M1S35_03060	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S35_03080	COG2096	Adenosyltransferase
M1S35_03130	COG0285	dihydrofolate synthase activity
M1S35_03150	COG0450	alkyl hydroperoxide reductase
M1S35_03165	COG0477	Major facilitator Superfamily
M1S35_03170	COG1272	protein, Hemolysin III
M1S35_03200	COG0183	Belongs to the thiolase family
M1S35_03205	COG2207	Transcriptional regulator
M1S35_03225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S35_03245	COG0183	Belongs to the thiolase family
M1S35_03255	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S35_03255	COG2885	chlorophyll binding
M1S35_03265	COG1690	Belongs to the RtcB family
M1S35_03270	COG0833	amino acid
M1S35_03280	COG2233	PERMEase
M1S35_03285	COG1217	gtp-binding protein TYPA
M1S35_03310	COG2094	Belongs to the DNA glycosylase MPG family
M1S35_03330	COG1902	pentaerythritol trinitrate reductase activity
M1S35_03345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S35_03350	COG0354	folic acid binding
M1S35_03360	COG3189	MarR family transcriptional regulator
M1S35_03365	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S35_03370	COG3422	double-strand break repair
M1S35_03410	COG0840	transmembrane signaling receptor activity
M1S35_03430	COG5510	response to toxic substance
M1S35_03440	COG2832	Protein of unknown function (DUF454)
M1S35_03445	COG1376	ErfK ybiS ycfS ynhG family protein
M1S35_03485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S35_03495	COG1289	transmembrane transporter activity
M1S35_03500	COG2814	Major facilitator Superfamily
M1S35_03520	COG1115	amino acid carrier protein
M1S35_03525	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S35_03530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S35_03535	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S35_03565	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S35_03575	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S35_03580	COG1077	Cell shape determining protein MreB Mrl
M1S35_03585	COG1792	Involved in formation and maintenance of cell shape
M1S35_03590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S35_03595	COG0424	maF-like protein
M1S35_03600	COG1530	ribonuclease E activity
M1S35_03610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S35_03620	COG0560	Phosphoserine phosphatase
M1S35_03630	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S35_03655	COG2207	Transcriptional regulator
M1S35_03675	COG1113	amino acid transport
M1S35_03680	COG2828	Protein conserved in bacteria
M1S35_03685	COG0142	geranyltranstransferase activity
M1S35_03690	COG2315	Protein conserved in bacteria
M1S35_03705	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S35_03725	COG2194	sulfuric ester hydrolase activity
M1S35_03730	COG0745	RESPONSE REGULATOR receiver
M1S35_03735	COG0642	Histidine kinase
M1S35_03745	COG0004	ammonium transporteR
M1S35_03750	COG0583	DNA-binding transcription factor activity
M1S35_03770	COG0525	valine-tRNA ligase activity
M1S35_03780	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_03790	COG0393	Putative heavy-metal-binding
M1S35_03795	COG0393	Putative heavy-metal-binding
M1S35_03800	COG1538	Outer membrane efflux protein
M1S35_03810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S35_03815	COG0671	phosphoesterase, PA-phosphatase related
M1S35_03845	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S35_03860	COG1648	precorrin-2 dehydrogenase activity
M1S35_03860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S35_03865	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S35_03870	COG1733	regulation of RNA biosynthetic process
M1S35_03880	COG0531	amino acid
M1S35_03895	COG0321	lipoyl(octanoyl) transferase activity
M1S35_03900	COG2921	Belongs to the UPF0250 family
M1S35_03940	COG2009	succinate dehydrogenase
M1S35_03945	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S35_03950	COG1053	succinate dehydrogenase
M1S35_03955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S35_03980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S35_04000	COG2354	Protein conserved in bacteria
M1S35_04005	COG2321	neutral zinc metallopeptidase
M1S35_04025	COG2843	Capsule synthesis protein
M1S35_04040	COG0589	response to stress
M1S35_04060	COG0505	Belongs to the CarA family
M1S35_04085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S35_04090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S35_04140	COG0477	Major facilitator Superfamily
M1S35_04145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S35_04160	COG1597	lipid kinase activity
M1S35_04165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S35_04190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S35_04195	COG0584	glycerophosphoryl diester phosphodiesterase
M1S35_04215	COG0741	lytic transglycosylase activity
M1S35_04235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S35_04250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S35_04280	COG0778	Nitroreductase
M1S35_04295	COG1929	Belongs to the glycerate kinase type-1 family
M1S35_04300	COG0243	molybdopterin cofactor binding
M1S35_04305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S35_04310	COG3339	Conserved Protein
M1S35_04320	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S35_04335	COG1113	amino acid transport
M1S35_04345	COG0019	diaminopimelate decarboxylase activity
M1S35_04355	COG1280	lysine exporter protein (LysE YggA)
M1S35_04360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S35_04390	COG0463	Glycosyl transferase, family 2
M1S35_04410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S35_04445	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S35_04450	COG1136	(ABC) transporter
M1S35_04455	COG0658	competence protein
M1S35_04455	COG2333	competence protein COMEC
M1S35_04465	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S35_04465	COG0616	signal peptide processing
M1S35_04470	COG0596	Alpha beta hydrolase
M1S35_04475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S35_04485	COG0628	permease
M1S35_04520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S35_04540	COG0823	Involved in the tonB-independent uptake of proteins
M1S35_04560	COG0824	Thioesterase
M1S35_04565	COG1473	amidohydrolase
M1S35_04585	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S35_04585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S35_04590	COG2814	Major facilitator Superfamily
M1S35_04600	COG1024	Enoyl-CoA hydratase
M1S35_04605	COG1051	belongs to the nudix hydrolase family
M1S35_04605	COG1056	cytidyltransferase-related domain
M1S35_04615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S35_04630	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S35_04645	COG4625	pathogenesis
M1S35_04650	COG0583	DNA-binding transcription factor activity
M1S35_04655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S35_04660	COG4208	sulfate ABC transporter
M1S35_04665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S35_04675	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S35_04680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S35_04685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S35_04705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S35_04720	COG0681	Belongs to the peptidase S26 family
M1S35_04735	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S35_04745	COG1381	Involved in DNA repair and RecF pathway recombination
M1S35_04750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S35_04760	COG4221	oxidoreductase activity
M1S35_04790	COG0436	Aminotransferase
M1S35_04810	COG0556	nucleotide-excision repair
M1S35_04865	COG2070	2-Nitropropane dioxygenase
M1S35_04895	COG1215	transferase activity, transferring glycosyl groups
M1S35_04910	COG0415	Belongs to the DNA photolyase family
M1S35_04920	COG1252	NADH dehydrogenase
M1S35_04925	COG1686	Belongs to the peptidase S11 family
M1S35_04940	COG1187	pseudouridine synthase activity
M1S35_04965	COG0477	Major facilitator Superfamily
M1S35_04970	COG0583	DNA-binding transcription factor activity
M1S35_04975	COG1823	symporter activity
M1S35_04985	COG0612	Peptidase, M16
M1S35_05010	COG0352	thiamine-phosphate diphosphorylase activity
M1S35_05045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S35_05060	COG1309	transcriptional regulator
M1S35_05070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S35_05075	COG0076	glutamate decarboxylase activity
M1S35_05085	COG1522	sequence-specific DNA binding
M1S35_05090	COG3961	Belongs to the TPP enzyme family
M1S35_05095	COG1113	amino acid transport
M1S35_05100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S35_05105	COG0573	inorganic phosphate transmembrane transporter activity
M1S35_05115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S35_05120	COG0616	signal peptide processing
M1S35_05155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S35_05160	COG1686	Belongs to the peptidase S11 family
M1S35_05185	COG0583	DNA-binding transcription factor activity
M1S35_05190	COG1067	ATP-dependent peptidase activity
M1S35_05235	COG1966	Carbon starvation protein
M1S35_05240	COG2879	small protein
M1S35_05275	COG2508	Transcriptional regulator
M1S35_05275	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S35_05295	COG1113	amino acid transport
M1S35_05300	COG0583	DNA-binding transcription factor activity
M1S35_05305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S35_05310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S35_05320	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_05330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S35_05335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S35_05335	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S35_05370	COG2814	Major facilitator Superfamily
M1S35_05375	COG4948	Mandelate Racemase Muconate Lactonizing
M1S35_05385	COG1309	transcriptional regulator
M1S35_05405	COG1741	Belongs to the pirin family
M1S35_05415	COG2964	Protein conserved in bacteria
M1S35_05430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S35_05435	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S35_05440	COG4605	iron ion homeostasis
M1S35_05445	COG4604	ABC transporter, ATP-binding protein
M1S35_05450	COG4607	ABC-type enterochelin transport system periplasmic component
M1S35_05455	COG4774	siderophore transport
M1S35_05465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S35_05470	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S35_05475	COG1535	isochorismatase
M1S35_05475	COG3433	isochorismatase activity
M1S35_05490	COG1132	(ABC) transporter
M1S35_05495	COG1132	(ABC) transporter
M1S35_05500	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S35_05510	COG1169	isochorismate synthase
M1S35_05525	COG3739	integral membrane protein
M1S35_05550	COG0302	gtp cyclohydrolase
M1S35_05560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S35_05590	COG0308	aminopeptidase N
M1S35_05595	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S35_05610	COG0174	glutamine synthetase
M1S35_05620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S35_05655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S35_05660	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1S35_05665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S35_05685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S35_05690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S35_05695	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S35_05710	COG1960	acyl-CoA dehydrogenase activity
M1S35_05715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S35_05720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S35_05730	COG2223	nitrite transmembrane transporter activity
M1S35_05740	COG0024	Methionine aminopeptidase
M1S35_05745	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S35_05760	COG2207	Transcriptional regulator
M1S35_05785	COG2951	lytic endotransglycosylase activity
M1S35_05790	COG0772	Belongs to the SEDS family
M1S35_05805	COG0842	Transport permease protein
M1S35_05810	COG1131	(ABC) transporter
M1S35_05855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S35_05870	COG4215	(ABC) transporter
M1S35_05875	COG4160	amino acid transport
M1S35_05880	COG4598	ABC transporter
M1S35_05890	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S35_05895	COG0826	peptidase U32
M1S35_05900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S35_05915	COG1720	tRNA m6t6A37 methyltransferase activity
M1S35_05925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S35_05940	COG0642	Histidine kinase
M1S35_05950	COG0494	nUDIX hydrolase
M1S35_05960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S35_05965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S35_05970	COG3139	Protein of unknown function (DUF1315)
M1S35_05975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S35_05980	COG1301	dicarboxylic acid transport
M1S35_05985	COG1960	acyl-CoA dehydrogenase activity
M1S35_05990	COG2819	hydrolase of the alpha beta superfamily
M1S35_06000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S35_06010	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S35_06015	COG1234	tRNA 3'-trailer cleavage
M1S35_06045	COG2363	Small membrane protein
M1S35_06070	COG0513	Belongs to the DEAD box helicase family
M1S35_06080	COG0778	Nitroreductase
M1S35_06435	COG1286	toxin biosynthetic process
M1S35_06460	COG4783	chaperone-mediated protein folding
M1S35_06465	COG1610	YqeY-like protein
M1S35_06565	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S35_06590	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1S35_06595	COG0786	glutamate:sodium symporter activity
M1S35_06605	COG2186	Transcriptional regulator
M1S35_06655	COG0477	Major facilitator Superfamily
M1S35_06685	COG2985	domain, Protein
M1S35_06695	COG2995	paraquat-inducible protein a
M1S35_06700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M1S35_06700	COG3008	intermembrane lipid transfer
M1S35_06710	COG1794	racemase activity, acting on amino acids and derivatives
M1S35_06805	COG0488	(ABC) transporter
M1S35_06810	COG3173	Aminoglycoside phosphotransferase
M1S35_06820	COG2433	Pfam Transposase IS66
M1S35_06860	COG1301	dicarboxylic acid transport
M1S35_06870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S35_06875	COG2011	ABC-type metal ion transport system permease component
M1S35_06880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S35_06885	COG1464	Belongs to the NlpA lipoprotein family
M1S35_06890	COG0151	Belongs to the GarS family
M1S35_06895	COG0138	bifunctional purine biosynthesis protein purh
M1S35_06900	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S35_06930	COG2308	Evidence 4 Homologs of previously reported genes of
M1S35_06940	COG1305	Transglutaminase-like
M1S35_06950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S35_06955	COG0305	Participates in initiation and elongation during chromosome replication
M1S35_06980	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S35_06990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S35_06995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S35_07020	COG0726	polysaccharide deacetylase
M1S35_07020	COG1649	PFAM Uncharacterised BCR, COG1649
M1S35_07025	COG1215	transferase activity, transferring glycosyl groups
M1S35_07030	COG3658	cytochrome
M1S35_07040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S35_07055	COG0583	DNA-binding transcription factor activity
M1S35_07075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S35_07080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S35_07095	COG1960	acyl-CoA dehydrogenase activity
M1S35_07100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S35_07105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S35_07130	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S35_07135	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S35_07145	COG2205	protein histidine kinase activity
M1S35_07150	COG0745	RESPONSE REGULATOR receiver
M1S35_07155	COG0174	glutamine synthetase
M1S35_07175	COG0729	surface antigen
M1S35_07200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S35_07205	COG2814	Major facilitator Superfamily
M1S35_07220	COG0583	DNA-binding transcription factor activity
M1S35_07235	COG1187	pseudouridine synthase activity
M1S35_07255	COG0802	atpase or kinase
M1S35_07260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S35_07270	COG1923	regulation of RNA biosynthetic process
M1S35_07275	COG0697	spore germination
M1S35_07290	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S35_07300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S35_07305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S35_07305	COG0519	Catalyzes the synthesis of GMP from XMP
M1S35_07310	COG4302	ethanolamine ammonia-lyase activity
M1S35_07315	COG4303	Ethanolamine ammonia lyase large subunit
M1S35_07320	COG0531	amino acid
M1S35_07340	COG1454	alcohol dehydrogenase
M1S35_07345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S35_07355	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S35_07375	COG0308	aminopeptidase N
M1S35_07385	COG4221	oxidoreductase activity
M1S35_07395	COG1605	Chorismate mutase
M1S35_07415	COG1309	transcriptional regulator
M1S35_07425	COG0668	transmembrane transport
M1S35_07460	COG4773	Receptor
M1S35_07480	COG0488	(ABC) transporter
M1S35_07485	COG0589	response to stress
M1S35_07510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S35_07520	COG3135	benzoate transporter
M1S35_07525	COG1522	sequence-specific DNA binding
M1S35_07535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S35_07540	COG0583	DNA-binding transcription factor activity
M1S35_07550	COG0183	Belongs to the thiolase family
M1S35_07560	COG2030	dehydratase
M1S35_07565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S35_07580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S35_07590	COG0824	Thioesterase
M1S35_07595	COG1454	alcohol dehydrogenase
M1S35_07605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S35_07625	COG0069	glutamate synthase activity
M1S35_07715	COG3620	sequence-specific DNA binding
M1S35_07920	COG1598	PFAM Uncharacterised protein family UPF0150
M1S35_08025	COG2814	Major facilitator Superfamily
M1S35_08040	COG0511	ligase activity, forming carbon-carbon bonds
M1S35_08060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S35_08060	COG1116	anion transmembrane transporter activity
M1S35_08065	COG0745	RESPONSE REGULATOR receiver
M1S35_08075	COG2146	nitrite reductase [NAD(P)H] activity
M1S35_08075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S35_08080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S35_08085	COG0243	molybdopterin cofactor binding
M1S35_08095	COG0243	molybdopterin cofactor binding
M1S35_08100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S35_08115	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S35_08115	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S35_08120	COG0303	'Molybdopterin
M1S35_08130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S35_08135	COG0697	spore germination
M1S35_08155	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S35_08160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S35_08215	COG2204	response regulator
M1S35_08220	COG3852	Histidine kinase
M1S35_08240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S35_08245	COG0575	Belongs to the CDS family
M1S35_08280	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S35_08295	COG2137	regulation of response to DNA damage stimulus
M1S35_08305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S35_08310	COG1011	Hydrolase
M1S35_08335	COG1522	sequence-specific DNA binding
M1S35_08345	COG1113	amino acid transport
M1S35_08365	COG0659	secondary active sulfate transmembrane transporter activity
M1S35_08370	COG2135	peptidase activity
M1S35_08385	COG5001	Diguanylate cyclase
M1S35_08385	COG3300	MHYT domain
M1S35_08405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S35_08405	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S35_08405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S35_08410	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S35_08415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S35_08415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S35_08445	COG0024	Methionine aminopeptidase
M1S35_08450	COG0583	DNA-binding transcription factor activity
M1S35_08460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S35_08465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S35_08470	COG0516	GMP reductase activity
M1S35_08470	COG0517	IMP dehydrogenase activity
M1S35_08495	COG0552	protein localization to endoplasmic reticulum
M1S35_08505	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S35_08520	COG4890	Cyd operon protein YbgT
M1S35_08525	COG1294	oxidase, subunit
M1S35_08540	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S35_08550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S35_08555	COG4774	siderophore transport
M1S35_08570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S35_08575	COG0569	domain protein
M1S35_08580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S35_08610	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S35_08615	COG0542	response to heat
M1S35_08640	COG1902	pentaerythritol trinitrate reductase activity
M1S35_08640	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S35_08685	COG2323	membrane
M1S35_08690	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S35_08700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S35_08705	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S35_08710	COG0183	Belongs to the thiolase family
M1S35_08715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S35_08720	COG0596	Alpha beta hydrolase
M1S35_08725	COG2271	Major facilitator Superfamily
M1S35_08730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S35_08735	COG3485	protocatechuate 3,4-dioxygenase
M1S35_08740	COG3485	protocatechuate 3,4-dioxygenase
M1S35_08745	COG0710	3-dehydroquinate dehydratase activity
M1S35_08750	COG3420	alginic acid biosynthetic process
M1S35_08755	COG3659	wide pore channel activity
M1S35_08760	COG4993	Dehydrogenase
M1S35_08770	COG2391	methyltransferase activity
M1S35_08785	COG1414	Transcriptional regulator
M1S35_08790	COG0583	DNA-binding transcription factor activity
M1S35_08795	COG1960	acyl-CoA dehydrogenase activity
M1S35_08820	COG2814	Major facilitator Superfamily
M1S35_08830	COG0154	amidase activity
M1S35_08850	COG4638	Rieske (2fe-2S)
M1S35_08860	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_08870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S35_08880	COG3733	amine oxidase
M1S35_08890	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_08900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S35_08905	COG0183	Belongs to the thiolase family
M1S35_08910	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S35_08915	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S35_08925	COG4829	muconolactone delta-isomerase
M1S35_08930	COG4948	Mandelate Racemase Muconate Lactonizing
M1S35_08935	COG0583	DNA-binding transcription factor activity
M1S35_08945	COG2186	Transcriptional regulator
M1S35_08965	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_08985	COG1960	acyl-CoA dehydrogenase activity
M1S35_08990	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_08995	COG3829	transcription factor binding
M1S35_09005	COG3162	membrane
M1S35_09020	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_09035	COG0753	catalase activity
M1S35_09055	COG1846	Transcriptional regulator
M1S35_09060	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S35_09060	COG1902	pentaerythritol trinitrate reductase activity
M1S35_09070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S35_09100	COG1309	transcriptional regulator
M1S35_09110	COG1335	isochorismatase
M1S35_09115	COG0583	DNA-binding transcription factor activity
M1S35_09125	COG0475	glutathione-regulated potassium exporter activity
M1S35_09125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S35_09135	COG1473	amidohydrolase
M1S35_09145	COG2831	hemolysin activation secretion protein
M1S35_09150	COG3210	domain, Protein
M1S35_09180	COG2188	Transcriptional regulator
M1S35_09195	COG0583	DNA-binding transcription factor activity
M1S35_09225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S35_09255	COG1566	PFAM secretion protein HlyD family protein
M1S35_09270	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_09275	COG0129	dihydroxy-acid dehydratase activity
M1S35_09285	COG0583	DNA-binding transcription factor activity
M1S35_09290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S35_09300	COG2084	Dehydrogenase
M1S35_09305	COG2207	Transcriptional regulator
M1S35_09320	COG1064	alcohol dehydrogenase
M1S35_09330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S35_09335	COG1120	ATPase activity
M1S35_09355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S35_09475	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S35_09525	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_09540	COG2207	Transcriptional regulator
M1S35_09550	COG2205	protein histidine kinase activity
M1S35_09555	COG0745	RESPONSE REGULATOR receiver
M1S35_09560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S35_09565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S35_09570	COG1538	Outer membrane efflux protein
M1S35_09580	COG2072	flavoprotein involved in K transport
M1S35_09600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S35_09620	COG3539	Fimbrial protein
M1S35_09650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S35_09660	COG0753	catalase activity
M1S35_09675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S35_09735	COG3433	isochorismatase activity
M1S35_09735	COG1535	isochorismatase
M1S35_09740	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_09745	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S35_09750	COG4149	molybdate abc transporter
M1S35_09755	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S35_09765	COG4638	Rieske (2fe-2S)
M1S35_09770	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S35_09775	COG0543	2 iron, 2 sulfur cluster binding
M1S35_09775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S35_09800	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_09815	COG2207	Transcriptional regulator
M1S35_09825	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_09830	COG2610	gluconate transmembrane transporter activity
M1S35_09840	COG0583	DNA-binding transcription factor activity
M1S35_09850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S35_09855	COG2031	fatty acid transporter
M1S35_09860	COG0183	Belongs to the thiolase family
M1S35_09865	COG0583	DNA-binding transcription factor activity
M1S35_09870	COG0583	DNA-binding transcription factor activity
M1S35_09885	COG1027	Aspartate ammonia-lyase
M1S35_09895	COG0477	Major facilitator Superfamily
M1S35_09915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S35_09920	COG4521	taurine ABC transporter
M1S35_09935	COG2188	Transcriptional regulator
M1S35_09945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S35_09950	COG1733	regulation of RNA biosynthetic process
M1S35_09955	COG2207	Transcriptional regulator
M1S35_09955	COG3708	Transcriptional regulator
M1S35_09970	COG0730	response to heat
M1S35_09985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S35_09985	COG3453	Protein conserved in bacteria
M1S35_09995	COG3781	membrane
M1S35_10000	COG1063	alcohol dehydrogenase
M1S35_10010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S35_10015	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S35_10020	COG0022	dehydrogenase e1 component
M1S35_10025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S35_10030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S35_10045	COG3706	GGDEF domain
M1S35_10060	COG0133	tryptophan synthase activity
M1S35_10070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S35_10105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S35_10130	COG2226	methyltransferase
M1S35_10185	COG0842	Transport permease protein
M1S35_10190	COG0842	Transport permease protein
M1S35_10195	COG1131	(ABC) transporter
M1S35_10210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S35_10215	COG4773	Receptor
M1S35_10235	COG0730	response to heat
M1S35_10240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S35_10260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S35_10275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S35_10315	COG4264	IucA IucC family
M1S35_10320	COG4264	IucA IucC family
M1S35_10340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S35_10355	COG1960	acyl-CoA dehydrogenase activity
M1S35_10360	COG1960	acyl-CoA dehydrogenase activity
M1S35_10365	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S35_10370	COG2207	Transcriptional regulator
M1S35_10375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S35_10380	COG0776	regulation of translation
M1S35_10405	COG0822	iron-sulfur transferase activity
M1S35_10410	COG0316	Belongs to the HesB IscA family
M1S35_10440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S35_10460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S35_10465	COG0702	epimerase
M1S35_10500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S35_10510	COG0339	signal peptide processing
M1S35_10560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S35_10565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S35_10595	COG0776	regulation of translation
M1S35_10660	COG0084	hydrolase, TatD family'
M1S35_10680	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S35_10685	COG1132	(ABC) transporter
M1S35_10695	COG0811	peptide transport
M1S35_10700	COG1475	DNA binding
M1S35_10705	COG1192	Involved in chromosome partitioning
M1S35_10715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S35_10730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S35_10735	COG0191	fructose-bisphosphate aldolase activity
M1S35_10755	COG0424	maF-like protein
M1S35_10760	COG2850	peptidyl-arginine hydroxylation
M1S35_10770	COG0640	Transcriptional regulator
M1S35_10780	COG3619	membrane
M1S35_10785	COG3122	Protein conserved in bacteria
M1S35_10790	COG1132	(ABC) transporter
M1S35_10810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S35_10815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S35_10825	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S35_10825	COG0506	proline dehydrogenase activity
M1S35_10825	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S35_10830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S35_10845	COG3698	Phosphodiester glycosidase
M1S35_10855	COG2353	YceI-like domain
M1S35_10865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S35_10915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S35_10915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S35_10940	COG3539	Fimbrial protein
M1S35_10970	COG0697	spore germination
M1S35_10980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S35_10990	COG0583	DNA-binding transcription factor activity
M1S35_11010	COG1309	transcriptional regulator
M1S35_11025	COG1522	sequence-specific DNA binding
M1S35_11035	COG1126	abc transporter atp-binding protein
M1S35_11040	COG0765	amino acid transport
M1S35_11045	COG0765	amino acid transport
M1S35_11075	COG1464	Belongs to the NlpA lipoprotein family
M1S35_11085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S35_11090	COG2011	ABC-type metal ion transport system permease component
M1S35_11095	COG0012	GTP binding
M1S35_11120	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S35_11160	COG0386	Belongs to the glutathione peroxidase family
M1S35_11170	COG0436	Aminotransferase
M1S35_11210	COG3634	alkyl hydroperoxide reductase activity
M1S35_11225	COG0583	DNA-binding transcription factor activity
M1S35_11230	COG0798	PFAM Bile acid sodium symporter
M1S35_11235	COG0640	Transcriptional regulator
M1S35_11250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S35_11260	COG0583	DNA-binding transcription factor activity
M1S35_11270	COG1953	Uracil, thiamine, allantoin
M1S35_11280	COG2175	clavaminate synthase activity
M1S35_11285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S35_11290	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S35_11295	COG4521	taurine ABC transporter
M1S35_11305	COG0477	Major facilitator Superfamily
M1S35_11325	COG1271	oxidase subunit
M1S35_11330	COG1294	oxidase, subunit
M1S35_11340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S35_11360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S35_11380	COG3052	prosthetic group binding
M1S35_11385	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S35_11395	COG2814	Major facilitator Superfamily
M1S35_11415	COG1346	cytolysis
M1S35_11425	COG0583	DNA-binding transcription factor activity
M1S35_11430	COG0625	glutathione transferase activity
M1S35_11435	COG0625	glutathione transferase activity
M1S35_11440	COG0583	DNA-binding transcription factor activity
M1S35_11455	COG1045	serine acetyltransferase
M1S35_11460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S35_11465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S35_11475	COG1280	lysine exporter protein (LysE YggA)
M1S35_11490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S35_11495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S35_11500	COG1126	abc transporter atp-binding protein
M1S35_11505	COG0765	amino acid transport
M1S35_11510	COG0765	amino acid transport
M1S35_11530	COG0784	Response regulator, receiver
M1S35_11530	COG2205	protein histidine kinase activity
M1S35_11550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S35_11570	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_11620	COG0583	DNA-binding transcription factor activity
M1S35_11655	COG2814	Major facilitator Superfamily
M1S35_11665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S35_11670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S35_11675	COG2814	Major facilitator Superfamily
M1S35_11680	COG1960	acyl-CoA dehydrogenase activity
M1S35_11685	COG1024	Enoyl-CoA hydratase
M1S35_11690	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_11695	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S35_11700	COG0183	Belongs to the thiolase family
M1S35_11710	COG2814	Major facilitator Superfamily
M1S35_11720	COG1024	Enoyl-CoA hydratase
M1S35_11735	COG1960	acyl-CoA dehydrogenase activity
M1S35_11740	COG2814	Major facilitator Superfamily
M1S35_11745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S35_11750	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S35_11765	COG3842	ATPase activity
M1S35_11770	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S35_11780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S35_11785	COG1414	Transcriptional regulator
M1S35_11795	COG0583	DNA-binding transcription factor activity
M1S35_11800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S35_11805	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_11815	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S35_11825	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_11830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S35_11835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S35_11840	COG2267	carboxylic ester hydrolase activity
M1S35_11860	COG3038	cytochrome b561
M1S35_11865	COG0753	catalase activity
M1S35_11900	COG2050	protein possibly involved in aromatic compounds catabolism
M1S35_11910	COG3327	negative regulation of DNA-templated transcription, initiation
M1S35_11915	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S35_11920	COG0183	Belongs to the thiolase family
M1S35_11925	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S35_11930	COG1024	Enoyl-CoA hydratase
M1S35_11935	COG1024	Enoyl-CoA hydratase
M1S35_11940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S35_11945	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S35_11950	COG3396	Phenylacetate-CoA oxygenase
M1S35_11955	COG3460	Phenylacetate-CoA oxygenase
M1S35_11960	COG3396	Phenylacetate-CoA oxygenase
M1S35_11965	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_11965	COG2030	dehydratase
M1S35_11970	COG1760	l-serine dehydratase
M1S35_11975	COG0531	amino acid
M1S35_11980	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_11995	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S35_12005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S35_12025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S35_12035	COG0789	Transcriptional regulator
M1S35_12050	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S35_12065	COG2807	transmembrane transport
M1S35_12070	COG0590	tRNA wobble adenosine to inosine editing
M1S35_12190	COG1116	anion transmembrane transporter activity
M1S35_12195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S35_12205	COG0864	Transcriptional regulator
M1S35_12225	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S35_12230	COG0439	Biotin carboxylase
M1S35_12245	COG1063	alcohol dehydrogenase
M1S35_12255	COG1309	transcriptional regulator
M1S35_12275	COG0038	chloride channel
M1S35_12280	COG4770	biotin carboxylase activity
M1S35_12300	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S35_12305	COG0583	DNA-binding transcription factor activity
M1S35_12355	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S35_12375	COG2814	Major facilitator Superfamily
M1S35_12390	COG1560	Kdo2-lipid A biosynthetic process
M1S35_12400	COG5006	permease, DMT superfamily
M1S35_12405	COG1522	sequence-specific DNA binding
M1S35_12420	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S35_12430	COG4122	O-methyltransferase activity
M1S35_12460	COG1538	Outer membrane efflux protein
M1S35_12465	COG1137	ATPase activity
M1S35_12470	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S35_12480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S35_12485	COG0517	IMP dehydrogenase activity
M1S35_12485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S35_12520	COG2814	Major facilitator Superfamily
M1S35_12555	COG1278	Cold shock
M1S35_12560	COG1280	lysine exporter protein (LysE YggA)
M1S35_12590	COG1570	exodeoxyribonuclease VII activity
M1S35_12640	COG0583	DNA-binding transcription factor activity
M1S35_12650	COG4638	Rieske (2fe-2S)
M1S35_12655	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S35_12660	COG0543	2 iron, 2 sulfur cluster binding
M1S35_12660	COG0633	Ferredoxin
M1S35_12665	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_12670	COG3135	benzoate transporter
M1S35_12675	COG2814	Major facilitator Superfamily
M1S35_12690	COG1643	Atp-dependent helicase
M1S35_12695	COG0450	alkyl hydroperoxide reductase
M1S35_12705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S35_12715	COG3634	alkyl hydroperoxide reductase activity
M1S35_12735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S35_12740	COG0625	glutathione transferase activity
M1S35_12750	COG2885	chlorophyll binding
M1S35_12785	COG0542	response to heat
M1S35_12800	COG1765	OsmC-like protein
M1S35_12820	COG0667	Aldo Keto reductase
M1S35_12835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S35_12845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S35_12855	COG0527	aspartate kinase activity
M1S35_12865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S35_12875	COG3038	cytochrome b561
M1S35_12880	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S35_12885	COG2252	PERMEase
M1S35_12895	COG2072	flavoprotein involved in K transport
M1S35_12910	COG1741	Belongs to the pirin family
M1S35_12915	COG1309	transcriptional regulator
M1S35_12925	COG0300	oxidoreductase activity
M1S35_13040	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1S35_13130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1S35_13220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1S35_13270	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_13290	COG0531	amino acid
M1S35_13300	COG1113	amino acid transport
M1S35_13340	COG3209	COG3209 Rhs family protein
M1S35_13370	COG4269	membrane
M1S35_13385	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S35_13385	COG1902	pentaerythritol trinitrate reductase activity
M1S35_13395	COG2203	Gaf domain
M1S35_13395	COG3706	GGDEF domain
M1S35_13395	COG4251	negative regulation of phosphorylation
M1S35_13395	COG5001	Diguanylate cyclase
M1S35_13405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S35_13425	COG4172	Belongs to the ABC transporter superfamily
M1S35_13430	COG4239	(ABC) transporter, permease
M1S35_13435	COG4174	ABC transporter (Permease)
M1S35_13445	COG1388	LysM domain
M1S35_13445	COG0741	lytic transglycosylase activity
M1S35_13445	COG1388	LysM domain
M1S35_13445	COG0741	lytic transglycosylase activity
M1S35_13450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S35_13490	COG0583	DNA-binding transcription factor activity
M1S35_13495	COG1279	arginine transmembrane transporter activity
M1S35_13515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S35_13520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S35_13525	COG0006	proline dipeptidase activity
M1S35_13610	COG0741	lytic transglycosylase activity
M1S35_13610	COG0739	heme binding
M1S35_13610	COG1196	nuclear chromosome segregation
M1S35_13670	COG4695	Portal protein
M1S35_13755	COG0305	Participates in initiation and elongation during chromosome replication
M1S35_13835	COG2194	sulfuric ester hydrolase activity
M1S35_13880	COG0739	heme binding
M1S35_14205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S35_14230	COG3384	dioxygenase
M1S35_14240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S35_14245	COG2878	Part of a membrane complex involved in electron transport
M1S35_14250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S35_14275	COG0768	penicillin binding
M1S35_14280	COG0742	ribosomal rna small subunit methyltransferase
M1S35_14295	COG0830	nickel cation binding
M1S35_14305	COG0804	urea catabolic process
M1S35_14345	COG1253	flavin adenine dinucleotide binding
M1S35_14350	COG2851	Citrate transporter
M1S35_14400	COG1773	rubredoxin
M1S35_14405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S35_14415	COG0583	DNA-binding transcription factor activity
M1S35_14440	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S35_14445	COG4181	ATPase activity
M1S35_14490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S35_14510	COG0306	phosphate transporter
M1S35_14520	COG3958	Transketolase
M1S35_14525	COG3959	Transketolase, thiamine diphosphate binding domain
M1S35_14530	COG2271	Major facilitator Superfamily
M1S35_14535	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_14540	COG0583	DNA-binding transcription factor activity
M1S35_14555	COG2223	nitrite transmembrane transporter activity
M1S35_14560	COG2207	Transcriptional regulator
M1S35_14565	COG2066	Belongs to the glutaminase family
M1S35_14570	COG0242	peptide deformylase activity
M1S35_14575	COG0477	Major facilitator Superfamily
M1S35_14585	COG0028	Belongs to the TPP enzyme family
M1S35_14600	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_14605	COG2267	carboxylic ester hydrolase activity
M1S35_14615	COG2271	Major facilitator Superfamily
M1S35_14620	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S35_14630	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_14650	COG1414	Transcriptional regulator
M1S35_14665	COG1024	Enoyl-CoA hydratase
M1S35_14675	COG1215	transferase activity, transferring glycosyl groups
M1S35_14680	COG0726	polysaccharide deacetylase
M1S35_14680	COG1649	PFAM Uncharacterised BCR, COG1649
M1S35_14690	COG4681	YaeQ
M1S35_14700	COG0523	cobalamin synthesis protein
M1S35_14710	COG1607	acyl-coa hydrolase
M1S35_14720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S35_14725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S35_14730	COG1309	transcriptional regulator
M1S35_14755	COG2040	homocysteine
M1S35_14760	COG0531	amino acid
M1S35_14785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S35_14790	COG0477	Major facilitator Superfamily
M1S35_14910	COG0592	DNA-directed DNA polymerase activity
M1S35_14950	COG2026	Addiction module toxin, RelE StbE family
M1S35_15100	COG3755	Protein conserved in bacteria
M1S35_15110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S35_15180	COG0405	Gamma-glutamyltransferase
M1S35_15185	COG2814	Major facilitator Superfamily
M1S35_15195	COG2050	protein possibly involved in aromatic compounds catabolism
M1S35_15210	COG1090	epimerase
M1S35_15230	COG0420	3'-5' exonuclease activity
M1S35_15255	COG0735	belongs to the Fur family
M1S35_15260	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S35_15280	COG0121	glutamine amidotransferase
M1S35_15295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S35_15305	COG0210	DNA helicase
M1S35_15310	COG2885	chlorophyll binding
M1S35_15315	COG0204	Acyl-transferase
M1S35_15330	COG2894	cell division
M1S35_15350	COG1280	lysine exporter protein (LysE YggA)
M1S35_15355	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S35_15355	COG1674	ftsk spoiiie
M1S35_15360	COG0492	ferredoxin-NADP+ reductase activity
M1S35_15365	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S35_15375	COG0456	acetyltransferase
M1S35_15420	COG1981	membrane
M1S35_15435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S35_15435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S35_15455	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_15465	COG0657	acetylesterase activity
M1S35_15475	COG0473	3-isopropylmalate dehydrogenase activity
M1S35_15480	COG0583	DNA-binding transcription factor activity
M1S35_15500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S35_15525	COG0564	pseudouridine synthase activity
M1S35_15535	COG0358	DNA primase activity
M1S35_15550	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S35_15580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S35_15610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S35_15620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S35_15620	COG0352	thiamine-phosphate diphosphorylase activity
M1S35_15620	COG0351	phosphomethylpyrimidine kinase
M1S35_15625	COG1652	LysM domain
M1S35_15650	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S35_15655	COG3101	peptidyl-lysine hydroxylation
M1S35_15660	COG0009	L-threonylcarbamoyladenylate synthase
M1S35_15665	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S35_15670	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S35_15685	COG4106	trans-aconitate 2-methyltransferase activity
M1S35_15700	COG2226	methyltransferase
M1S35_15700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S35_15700	COG0596	Alpha beta hydrolase
M1S35_15705	COG1877	trehalose-phosphatase activity
M1S35_15710	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S35_15715	COG2223	nitrite transmembrane transporter activity
M1S35_15735	COG1196	nuclear chromosome segregation
M1S35_15745	COG0730	response to heat
M1S35_15760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S35_15770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S35_15820	COG0489	protein tyrosine kinase activity
M1S35_15830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S35_15830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S35_15860	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S35_15865	COG2081	HI0933 family
M1S35_15875	COG0668	transmembrane transport
M1S35_15895	COG0583	DNA-binding transcription factor activity
M1S35_15915	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S35_15920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S35_15950	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S35_15990	COG0745	RESPONSE REGULATOR receiver
M1S35_16010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S35_16020	COG2205	protein histidine kinase activity
M1S35_16090	COG4993	Dehydrogenase
M1S35_16115	COG0384	phenazine biosynthesis protein PhzF
M1S35_16140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S35_16155	COG0583	DNA-binding transcription factor activity
M1S35_16185	COG0583	DNA-binding transcription factor activity
M1S35_16200	COG0583	DNA-binding transcription factor activity
M1S35_16205	COG1053	succinate dehydrogenase
M1S35_16215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S35_16220	COG2814	Major facilitator Superfamily
M1S35_16225	COG1960	acyl-CoA dehydrogenase activity
M1S35_16230	COG0583	DNA-binding transcription factor activity
M1S35_16235	COG1063	alcohol dehydrogenase
M1S35_16265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S35_16270	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S35_16275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S35_16290	COG3667	copper resistance
M1S35_16295	COG2132	Multicopper oxidase
M1S35_16305	COG0561	phosphatase activity
M1S35_16310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S35_16335	COG1214	PFAM Peptidase M22, glycoprotease
M1S35_16385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S35_16395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S35_16400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S35_16405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S35_16465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S35_16475	COG1846	Transcriptional regulator
M1S35_16480	COG1764	response to oxidative stress
M1S35_16520	COG0037	tRNA processing
M1S35_16530	COG0248	Ppx GppA phosphatase
M1S35_16560	COG0072	phenylalanine-tRNA ligase activity
M1S35_16605	COG1238	metal cluster binding
M1S35_16610	COG0625	glutathione transferase activity
M1S35_16625	COG0318	PFAM AMP-dependent synthetase and ligase
M1S35_16630	COG3028	Belongs to the UPF0307 family
M1S35_16635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S35_16655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S35_16660	COG0617	tRNA 3'-terminal CCA addition
M1S35_16665	COG1555	photosystem II stabilization
M1S35_16670	COG3956	TIGRFAM MazG family protein
M1S35_16680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S35_16700	COG0784	Response regulator, receiver
M1S35_16700	COG2205	protein histidine kinase activity
M1S35_16700	COG5002	protein histidine kinase activity
M1S35_16705	COG1024	Enoyl-CoA hydratase
M1S35_16710	COG2084	Dehydrogenase
M1S35_16715	COG3622	Belongs to the hyi family
M1S35_16745	COG0697	spore germination
M1S35_16755	COG2814	Major facilitator Superfamily
M1S35_16760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S35_16770	COG0583	DNA-binding transcription factor activity
M1S35_16780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S35_16795	COG0084	hydrolase, TatD family'
M1S35_16810	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S35_16840	COG0440	acetolactate synthase activity
M1S35_16845	COG0028	Belongs to the TPP enzyme family
M1S35_16870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S35_16875	COG0577	efflux transmembrane transporter activity
M1S35_16875	COG1136	(ABC) transporter
M1S35_16880	COG1538	Outer membrane efflux protein
M1S35_16895	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S35_16900	COG1162	GTPase activity
M1S35_16910	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S35_16930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S35_16935	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_16975	COG2986	histidine ammonia-lyase
M1S35_16990	COG0318	PFAM AMP-dependent synthetase and ligase
M1S35_17000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S35_17045	COG1426	Protein conserved in bacteria
M1S35_17080	COG0793	Belongs to the peptidase S41A family
M1S35_17095	COG2267	carboxylic ester hydrolase activity
M1S35_17105	COG1012	belongs to the aldehyde dehydrogenase family
M1S35_17110	COG3265	gluconokinase activity
M1S35_17120	COG0800	Aldolase
M1S35_17130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S35_17135	COG0857	belongs to the CobB CobQ family
M1S35_17135	COG0280	phosphate acetyltransferase
M1S35_17140	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S35_17140	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S35_17160	COG0740	serine-type endopeptidase activity
M1S35_17170	COG4774	siderophore transport
M1S35_17180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S35_17190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S35_17190	COG2813	Specifically methylates the guanine in position
M1S35_17290	COG0788	formyltetrahydrofolate deformylase activity
M1S35_17315	COG4651	solute:proton antiporter activity
M1S35_17315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S35_17335	COG0724	RNA recognition motif
M1S35_17340	COG0210	DNA helicase
M1S35_17365	COG1733	regulation of RNA biosynthetic process
M1S35_17375	COG2900	Belongs to the SlyX family
M1S35_17380	COG0488	(ABC) transporter
M1S35_17385	COG1280	lysine exporter protein (LysE YggA)
M1S35_17390	COG1560	Kdo2-lipid A biosynthetic process
M1S35_17400	COG1301	dicarboxylic acid transport
M1S35_17455	COG0473	3-isopropylmalate dehydrogenase activity
M1S35_17520	COG0583	DNA-binding transcription factor activity
M1S35_17530	COG0625	glutathione transferase activity
M1S35_17535	COG2378	regulation of single-species biofilm formation
M1S35_17540	COG0546	phosphoglycolate phosphatase activity
M1S35_17550	COG1530	ribonuclease E activity
M1S35_17555	COG0318	PFAM AMP-dependent synthetase and ligase
M1S35_17570	COG0583	DNA-binding transcription factor activity
M1S35_17575	COG4221	oxidoreductase activity
M1S35_17580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S35_17590	COG0534	Mate efflux family protein
M1S35_17605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S35_17645	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S35_17650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S35_17665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S35_17675	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S35_17675	COG0644	oxidoreductase
M1S35_17680	COG0425	Belongs to the sulfur carrier protein TusA family
M1S35_17685	COG4535	Mg2 and Co2 transporter CorC
M1S35_17695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S35_17715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S35_17720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S35_17720	COG0475	glutathione-regulated potassium exporter activity
M1S35_17725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S35_17735	COG0484	heat shock protein binding
M1S35_17740	COG0789	Transcriptional regulator
M1S35_17745	COG0598	Magnesium transport protein CorA
M1S35_17760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S35_17765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S35_17770	COG1074	ATP-dependent DNA helicase activity
M1S35_17775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S35_17795	COG2226	methyltransferase
M1S35_17810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S35_17815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S35_17830	COG2111	Na H antiporter
M1S35_17830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S35_17835	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S35_17840	COG0651	ATP synthesis coupled electron transport
M1S35_17845	COG1863	multisubunit Na H antiporter MnhE subunit
M1S35_17850	COG2212	antiporter activity
M1S35_17855	COG1320	monovalent cation:proton antiporter activity
M1S35_17870	COG0195	Participates in both transcription termination and antitermination
M1S35_17920	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S35_17925	COG0237	dephospho-CoA kinase activity
M1S35_17935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S35_17950	COG0497	DNA recombination
M1S35_17960	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S35_17990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S35_17990	COG2169	Transcriptional regulator
M1S35_17995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S35_18060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S35_18075	COG0326	Molecular chaperone. Has ATPase activity
M1S35_18090	COG2056	Na+-H+ antiporter family
M1S35_18095	COG0596	Alpha beta hydrolase
M1S35_18190	COG0546	phosphoglycolate phosphatase activity
M1S35_18195	COG1716	ATPase activity
M1S35_18240	COG0181	hydroxymethylbilane synthase activity
M1S35_18250	COG3275	phosphorelay sensor kinase activity
M1S35_18270	COG1538	Outer membrane efflux protein
M1S35_18275	COG0697	spore germination
M1S35_18300	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S35_18305	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S35_18310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S35_18315	COG0772	Belongs to the SEDS family
M1S35_18340	COG4974	Belongs to the 'phage' integrase family
M1S35_18345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S35_18355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S35_18365	COG2197	response regulator
M1S35_18380	COG0793	Belongs to the peptidase S41A family
M1S35_18385	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S35_18390	COG0795	lipopolysaccharide-transporting ATPase activity
M1S35_18430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S35_18430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S35_18440	COG0004	ammonium transporteR
M1S35_18445	COG0347	Belongs to the P(II) protein family
M1S35_18505	COG0659	secondary active sulfate transmembrane transporter activity
M1S35_18510	COG0589	response to stress
M1S35_18555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S35_18565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S35_18585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S35_18600	COG0318	PFAM AMP-dependent synthetase and ligase
M1S35_18610	COG0477	Major facilitator Superfamily
M1S35_18615	COG2860	membrane
M1S35_18625	COG1253	flavin adenine dinucleotide binding
M1S35_18645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S35_18685	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S35_18695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S35_18765	COG0758	DNA mediated transformation
M1S35_18775	COG0697	spore germination
M1S35_18780	COG1309	transcriptional regulator
M1S35_18795	COG0386	Belongs to the glutathione peroxidase family
M1S35_18860	COG1121	(ABC) transporter
M1S35_18865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S35_18870	COG1280	lysine exporter protein (LysE YggA)
M1S35_18875	COG2837	iron assimilation
M1S35_18885	COG0281	malic enzyme
M1S35_18930	COG0519	Catalyzes the synthesis of GMP from XMP
M1S35_18930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S35_18935	COG4399	Belongs to the UPF0754 family
M1S35_18940	COG2259	Doxx family
M1S35_18945	COG0586	Pfam SNARE associated Golgi protein
M1S35_18960	COG1192	Involved in chromosome partitioning
M1S35_18970	COG0271	Belongs to the BolA IbaG family
M1S35_18990	COG2267	carboxylic ester hydrolase activity
M1S35_19010	COG3321	synthase
M1S35_19010	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S35_19010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S35_19010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S35_19015	COG1960	acyl-CoA dehydrogenase activity
M1S35_19025	COG2197	response regulator
M1S35_19035	COG3916	Acyl-homoserine-lactone synthase
M1S35_19040	COG0477	Major facilitator Superfamily
M1S35_19045	COG1024	Enoyl-CoA hydratase
M1S35_19050	COG1024	Enoyl-CoA hydratase
M1S35_19055	COG1960	acyl-CoA dehydrogenase activity
M1S35_19060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S35_19080	COG1113	amino acid transport
M1S35_19085	COG1113	amino acid transport
M1S35_19090	COG0251	oxidation-reduction process
M1S35_19130	COG0564	pseudouridine synthase activity
M1S35_19190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S35_19205	COG1802	Transcriptional regulator
M1S35_19215	COG1448	Aminotransferase
M1S35_19220	COG0277	FAD linked oxidase domain protein
M1S35_19230	COG2186	Transcriptional regulator
M1S35_19240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S35_19245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S35_19260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S35_19265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S35_19270	COG1216	Glycosyl transferase, family 2
M1S35_19300	COG2089	acid synthase
M1S35_19315	COG1083	cytidylyl-transferase
M1S35_19320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S35_19325	COG1086	Polysaccharide biosynthesis protein
M1S35_19330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S35_19335	COG1596	polysaccharide export
M1S35_19360	COG0728	peptidoglycan biosynthetic process
M1S35_19365	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S35_19425	COG0546	phosphoglycolate phosphatase activity
M1S35_19430	COG1028	Short-chain dehydrogenase reductase Sdr
M1S35_19450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S35_19455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S35_19460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S35_19465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S35_19470	COG1116	anion transmembrane transporter activity
M1S35_19475	COG1309	transcriptional regulator
M1S35_19480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S35_19490	COG0196	riboflavin kinase activity
M1S35_19495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S35_19505	COG1047	Peptidyl-prolyl cis-trans
M1S35_19545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S35_19550	COG0657	acetylesterase activity
M1S35_19570	COG0583	DNA-binding transcription factor activity
M1S35_19600	COG2951	lytic endotransglycosylase activity
M1S35_19605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S35_19620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S35_19630	COG0671	phosphoesterase, PA-phosphatase related
M1S35_19635	COG0861	Integral membrane protein TerC family
M1S35_19645	COG0754	glutathionylspermidine amidase activity
M1S35_19655	COG0402	S-adenosylhomocysteine deaminase activity
M1S35_19670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S35_19675	COG1230	cation diffusion facilitator family transporter
M1S35_19690	COG0706	membrane insertase activity
M1S35_19730	COG0358	DNA primase activity
M1S35_19785	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S35_19830	COG0587	DNA-directed DNA polymerase activity
M1S35_19845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S35_19845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S35_19895	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1S35_19895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S35_19900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S35_19940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S35_19985	COG1309	transcriptional regulator
M1S35_19995	COG1902	pentaerythritol trinitrate reductase activity
M1S35_20005	COG1979	alcohol dehydrogenase
M1S35_20020	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M1S35_20045	COG1063	alcohol dehydrogenase
M1S35_20125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S35_20145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system